occupational skin diseases: why, how and when? antti lauerma, m.d., ph.d. fioh figures: copyright...
TRANSCRIPT
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Occupational skin diseases: Why, How and When?
Antti Lauerma, M.D., Ph.D.
FIOH
Figures: copyright Blackwell (Rook, Textbook of Dermatology)
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Occupational Skin Disease
• A skin disease that is caused by physical, biological or chemical factor in work
• Also a worsening of pre-existing skin disease can be termed as occupational skin disease
• The start of occupational disease is considered to be the time a patient visited physician the first time
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Occupational skin diseases - How common?
• In Finland approximately 1000 cases every year (pop. 5 Million).
• Approximately 20% of all occupational diseases
• Frequency is stable
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Occupational skin diseases - what type?
• Most occupational skin diseases are contact dermatoses
• Allergic contact dermatitis
• Irritant contact dermatitis
• Contact urticaria
• Protein contact dermatitis
• Skin infections
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OCCUPATIONAL SKIN INFECTIONS
• Scabies
• Fleas
• Paravaccinia
• Erysipeloides
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OCCUPATIONAL SKIN CANCERS
• Basal cell carcinoma
• Spinous cell carcinoma
• Malignant melanoma
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OCCUPATIONAL PIGMENT CHANGES
• Melanodermia– Increased pigmentation
• Leukodermia– Decreased pigmentation
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OCCUPATIONAL ACNE
• Chloro-acne
• Oil acne
• Tar acne
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CONTACT URTICARIA
• Immunologic contact urticaria– Caused by proteins that act as allergens– Proteins penetrate through skin and bind to IgE
on the surface of mast cells– Binding causes histamine and other mediator
release resulting in urticaria– Sometimes generalized reactions occur– Latex allergy
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CONTACT URTICARIA
• Nonimmunologic contact urticaria– Caused by chemicals– Direct pharmacologic action on skin cells– No sensitization necessary– More common than suspected?
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PROTEIN CONTACT DERMATITIS
• Repeated contact urticaria from protein allergens cause eczema (dermatitis)
• Kitchen work (repeated exposure to food allergens
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PHOTOCONTACT DERMATITIS
• Toxic photocontact dermatitis (plants, psoralens)
• Allergic photocontact dermatitis (e.g., sunscreens)
• Permanent sensitization to light?
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Irritant contact dermatitis
• Disease of the stratum corneum
• Solvents: Removal of lipids
• Acids, alkalics, salts: Destroy proteins
• Dust: Direct mechanical destruction
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Irritant contact dermatitis (2)
• Endogenous factors: Dryness vs wetness
• Sweating
• Age
• Atopic predisposition
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Irritant contact dermatitis
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Occcupational irritant contact dermatitis
• 35% Washing
• 10% Solvents
• 6% Plastics and adhesives
• 6% Foodstuff
• 5% Dirty, wet work
• 5% Mineral oils
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Allergic contact dermatitis
• Caused by low-molecular weight haptens
• Hapten is “incomplete allergen”
• Binds to carrier protein for immunogenicity
• Low molecule weight enables penetration of hapten
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ALLERGIC CONTACT DERMATITIS - INDUCTION
• Induction (sensitization) occurs if hapten is allergenic and /or topical dosage is large enough
• Approximately 2 weeks later person is allergic to the same hapten chemical
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ALLERGIC CONTACT DERMATITIS - ELICITATION
• Hapten penetrates through stratum corneum of a sensitized individual
• A classical Type IV reaction ensues in the form of eczema/dermatitis
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ALLERGIC CONTACT DERMATITIS TO RUBBER
CHEMICALS
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ALLERGIC CONTACT DERMATITIS TO RUBBER IN
SOCKS
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ALLERGIC CONTACT DERMATITIS TO
PRESERVATIVE IN OINTMENT (KATHON CG)
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ALLERGIC CONTACT DERMATITIS TO CHROMIUM
IN CEMENT
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ALLERGIC CONTACT DERMATITIS TO PERFUME
IN SHAMPOO
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ALLERGIC CONTACT DERMATITIS TO NICKEL
SULPHATE - FACIAL CONTACT THROUGH
FINGERS
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ALLERGIC CONTACT DERMATITIS TO NICKEL
PRESENT IN KEYS HELD IN POCKET OF TROUSERS
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POMPHYLOX
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FUNGAL INFECTION (TRICHOPHYTON RUBRUM)
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ERTYHEMA AB IGNE
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ATOPIC DERMATITIS
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DIAGNOSIS OF OCCUPATIONAL SKIN DISEASE
• Patient history: Does skin disease relate to work?
• Exposure: Are there causative agents (allergens, irritants) in the work-place?
• Clinical symptoms: Are they in accordance to clinical disease?
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CLINICAL FEATURES OF OCCUPATIONAL SKIN DISEASE
• When did disease start?
• In which skin area was the first symptom?
• What is work technique?
• Free time, other works
• Cleaning measures
• Protection
• Vacation, holidays
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CLINICAL FEATURES OF CONTACT DERMATITIS
• Skin disease starts on the area of contact
• Dorsal aspects of hands and fingers, volar aspects of arms
• Redness, edema -> blisters, ulcerations
• Itch, pain, heat, stinging
• Contact dermatitis heals after exposure is discontinued
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CLINICAL FEATURES OF CONTACT URTICARIA
• Hives (edema) appear on sites of contact within minutes
• The hives disappear within 1-4 hours
• Mild: Only itching
• Severe: Systemic symptoms (anaphylaxis)
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DIAGNOSTIC TESTS
• PATCH TESTS
• PRICK TESTS
• SCRATCH TEST
• OPEN TEST
• USAGE TEST
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PATCH TESTS
• Diagnosis of allergic contact dermatitis• Hapten (~0.001-20%) in vehicle• Finn Chamber• 48 h apllication on back• Reading at 2 days, 4-5 days (7-9 days)• ?+ (erythema), + (erythema, edema), ++
(+vesiculation), +++ (+ bulla), IR (irritation)
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PRICK TESTS
• A drop of allergen placed on top of skin
• Skin broken with lancet
• Positive control histamine
• Negative control vehicle
• Positive reaction: at least 3 mm and histamine size
• Overall negative: Antihistamine
• Overall positive: Dermografismus