JePJOURNALOF CLINICALPATHOLOGYThe journal of the Association of Clinical Pathologists: A Registered Charity

Editor: David LoweAssistant Editor: Helen HolzelTechnical Editor: Andrea HorganEditorial Assistant: Mavis BurrellBMA House, Tavistock Square, London WC1H 9JR; Tel 0171 383 6209

EDITORIALBOAJRD

AL AppletonCC BirdAW BoylstonD BurnettJ Crocker

JD DaviesFV FlynnDJ GoldieJHE HayekFD Lee

JS LilleymanAJ MalcolmJH McCarthyRN PeelMD Penney

RS PereiraGL RidgwayC RobertsDN SlaterRC Spencer

Former Editors

Association ofClinical Pathologists

AG Signy 1944-72 HEM Kay 1972-80 G Slavin 1978-88 J Iilleyman 1986-92

President: Dr WR Timperley; President-Elect: Dr PM Emerson; Vice-Presidents: Dr PJ Fitzpatrick, Dr JD Davies;Chairman ofCouncil: Dr DM Harris; Honorary Secretary: Dr AJ Malcolm; Honorary Treasurer: Dr AC Ames; GeneralSecretary: Mrs JS Tumer, 221 Preston Road, Brighton BN1 6SA; Tel: (01273)561188; Fax: (01273) 541227

Cover illustration:

Visualisation ofimmunoglobulin genes byfluorescence in situhybridisation inphytohaemagglutininstimulated lymphocytes.Triple labelling for interphasenucleus withdiaminophenylindol (DAPI)(blue), a painting library forchromosome 22 (red), and aplasmid Ck probe (green).(See: Carvalho et al. In situvisualisation ofimmunoglobulin genes innormal and malignantlymphoid cells. Y Clin Pathol:MolPathol 1995;48:M1 58-64.)

Published by BMJ

Publishing Group andprinted in England byLatimer Trend & Co.,Plymouth

Information for Authors

Papers should be sent in duplicate to the Editors,Journal of Clinical Pathology, BMJ Publishing Group,BMA House, Tavistock Square, London WC1H 9JR.Telephone numbers: 0171 383 6209/6154. Fax number:0171 383 6668. They should be typewritten with doublespacing on one side of the paper only. The names of theauthors with initials or one forename should be followedby the name of the institution where the work was per-formed. An indication of the position held by each authormust be given in an accompanying letter to the Editors,and this should include the signatures of all authors onpapers with joint authorship. Guidelines on authorship aredetailed in Clin Pathol 1986;39:110. Results should notbe shown as both tables and graphs, and histograms shouldnot be used where tabular information would be moreappropriate.ARTICLES Papers should usually be no more than 2000words long and should report original research of relevanceto the understanding and practice of clinical pathology.They should be written in the standard format with astructured abstract. The abstract should contain the head-ings Aims, Methods, Results and Conclusions and be no morethan 250 words long. The body of the paper should haveseparate sections for the introduction, the methods and theresults, and the discussion. If statistics are used the methodsand confidence intervals should be stated. Authors areurged to seek expert advice if in doubt. Revised manuscriptsshould be submitted as hard copy and on disk. Detailedinstructions will be sent to authors on invitation to revise.Occasional Articles have a less rigid format, being 1500-2000 words in length. They are usually invited by theeditors, though unsolicited submissions will be considered.Single case reports and briefpapers (such as those describingnegative findings) will usually be considered only as ShortReports. The format for these is an unstructured 150 wordsummary, up to 1500 words of text, up to two tables or

figures (or one of each) and no more than 10 references.Letters to the Editor should normally refer to previouslypublished papers or make some point about the practice ofpathology. They are not intended to be a vehicle for thepresentation ofnew data unrelated to earlierJournal articles.

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13-7 cm or, in exceptional circumstances, 17-4 cm, tofit the column layout of the Journal. Colour reproductionis welcomed and is subsidised by the Journal; for detailsof costs to the author please contact the Journal office.ABBREVIATIONS Abbreviations must be spelt out on firstuse or be accompanied by explanation in the text. The useof non-standard abbreviations and acronyms should beavoided.Symbols and abbreviations should be in the Vancouverstyle.uNIrs All measurements should be given in SI units.REFERENCES The references must be given in the Van-couver style.REPRINTS These may be ordered when the proof is re-turned. Prices for large numbers of reprints available onrequest.

NOTICE TO ADVERTISERS Applications for advertisementspace and for rates should be addressed to the Ad-vertisement Manager, Journal of Clinical Pathology, BMJPublishing Group, BMA House, Tavistock Square, LondonWC1H 9JR.The J'ournal of Clinical Pathology is published monthly.The annual subscription rates (including Clinical MolecularPathology) are £278.00; USA $436.00. Orders should besent to The Subscription Manager, Journal ofClinical Patho-logy, BMJ Publishing Group, BMA House, TavistockSquare, London WC1H 9JR. Subscribers may pay for theirsubscriptions by Access, Visa, or American Express, byquoting on their order the credit or charge card preferred,together with the appropriate personal account number andexpiry date of the card. Orders can also be placed with anyleading subscription agent or bookseller. (For the con-venience of readers in the USA subscription orders, withor without payment, may also be sent to the British MedicalJournal, Box 408, Franklin, MA 02038, USA. All enquiries,however, must be addressed to the publisher in London.)All enquiries regarding air mail rates and single copiesalready published should be addressed to the publisher inLondon.

COPYRIGHT 1995 Journal of Clinical Pathology. Thispublication is copyright under the Berne Convention andthe Intemational Copyright Convention. All rights reserved.Apart from any relaxations permitted under national copy-right laws, no part of this publication may be reproduced,stored in a retrieval system or transmitted in any form or

by any means without the prior permission of the copyrightowners. Permission is not, however, required to copy ab-stracts of papers or of articles on condition that a fullreference to the source is shown. Multiple copying of thecontents of the publication without permission is alwaysillegal.Second class postage paid, at Rahway N. J. Postmaster tosend address changes to: Journal of Clinical Pathology c/oMercury Airfreight International Ltd. Inc., 2323 RandolphAvenue, Avenel, NJ 07001, USA.ISSN 0021-9746.

D TarinDR TurnerDA WmfieldB WoodcockEditor, BMJ

List of assessors

The members of the Editorial Board are indebted to the following for their help with the assessment of papers during the year to September 1995.

B J AddisM C AldridgeR AllakerJ A L AmessM C AndersonT AndersonI D AnsellP P AnthonyN A AthanasouJ BabbB BainS I A BaithunS S BanerjeeJ BellD P BentleyD BerneyP J BerryJ W BradfieldJ BreuerL J R BrownJ BrownC H BuckleyA D BurtE CanningN CaryD CatovskyR CerioH M ChapelT ChardB ChattopadhyayP L ChiodiniD M ClarkB CorrinA CoumbeJ E CrabtreeD CrawfordI A CreeJ CrockerJ CrowM H Cullen0 M CurlingP J DarbyshireS DasJ D DaviesP D DawkinsA DawnayD W DayA R S DeeryU DesselbergerS DillyM F DixonP DomizioL DoyalD DoyleC Du BoulayF P M DunneP DyerC EdwardsI 0 EllisV EmeryA M EmmersonG EvansS J EykynN L K Fagg

I D FarrellP FarthingC FeganC FisherA FleckK A FlemingJ FletcherF V FlynnG M ForbesC S FosterH FoxI M FranklinG L FrenchE GaleP J GallagherK C GatterJ F GeddesR H GeorgeR C GeorgeJ GerdesA T M GhoneimA A M GibsonH M GilmourJ GrangeT A GrayM GreavesD F R GriffithsM H GriffithsK M GrigorR GrunebergW GullickH HambleyP J HamiltonA M HanbyA L HarrisM HarrisI HarrisonC R M HayR J HayD K HenryA HerbertC S HerringtonR E HollimanD HopwoodS HumphreysR IlesJ IronsideP G IsaacsonS M IsmailC IsonA JackV JamesR JarrettI J M JeffreyD J JeffriesS JordanD H M JoynsonI JuhanJ W KeelingJ KeenanC KibblerS E KinseyN KirkhamP KiteG M KonatowiczA S Krajewski

P KyteP L LantosS LeadbeatterR E LeakeF D LeeJ LeeI M LeighD A LevisonJ S LilleymanS N LloydJ S LoweT T MacdonaldS J MachinR N M MacSweenC MakunuraA J MalcolmR R MarplesT MarrsD Y MasonK P McCarthyA C E McCartneyJ McClureJ O'D McGeeP McGooganG McKeeJ E McLaughlinA M McNicolS MedbakA MehtaS MehtarD H MelcherP J MillaP Morgan-CapnerP P MortimerP MossH NielsenA J NortonR T D OliverM G OrmerodR A OwenR J OwenF J ParadinasJ ParkinM C ParkinsonG PasvolR S PereiraL PerryM PignatelliG J PilkingtonA J PinchingT L PittB C PortmanA B PriceJ R QuineyC M QuinnP QuirkeB J RandallD S ReevesM M ReidW A ReidJ T ReillyP A RevellR RiddellG L Ridgway

R A RisdonB E RobertsA J RobertsonS RobinsonW R RocheT RogersP RoseD A RouseG N RuttyG M S ScottN ScottE A SheffieldM SheppardN ShettyM S M ShoushaM P E SlackD N SlaterN G P SlaterJ M SloanR J SokolR C SpencerG StampS G SubbuswamyD M SwirskyM SwornS TabaqchaliD A TabernerI C TalbotG A T TargettD TarinD Taylor-RobinsonJ ThompsonD S TompkinsD R TurnerJ C E UnderwoodA H C UttleyP A van DamP van der ValkP J van DiestP VanezisS VariendD VoakF WalkerR A WalkerB F WarrenR A WhileyW F WhimsterJ A WhittakerH L WhitwellJ WildeD L WilliamsD M WilliamsG T WilliamsP B WilsonA WinderD A WinfieldB E WoodcockA C WotherspoonP A WrightD H WrightJ I WyattA H W WyllieM D Yates

_7 Clin Pathol 1995;48:11 47 1147

I Clin Pathol 1995;48:1148-1151

Volume 48 * Author index

Key: (C) = Correspondence: (E) = Editorial: (L) = Leader

AAbad M, 57Abbas A, 368Abbot NC, 304Abdalla SH, 706Adachi Y, 137, 754Ades AE, 904Agbarakwe AE, 206Aguiar A, 787 (C)Aitola P, 645Al-Jassar AK, 185 (C)Al-Rafaie FN, 110Al Saati T, 826Al-Talib RK, 869Ala FA, 865Alderson D, 129Aleotti A, 553Alguacil-Garcia GF, 579Allen-Mersh TG, 270Allocati N, 1072Alonso MJ, 57Alvisi V, 553Amil Dias J, 787 (C)Anand CM, 214Anderson JR, 597 (L)Anderson SM, 415Andrade L, 53Andrion A, 856Annino L, 955Aqel NM, 185 (C)Arends JW, 408Armstrong C, 596 (C)Armstrong CJ, 689 (C)Asano Y, 115Ashbum D, 64, 689 (C)Athanasou NA, 950Atrah HI, 865Audouin J, 18Aung W, 84Austin EB, 1005Axon ATR, 939Aziza J, 826

BBaak JPA, 620Baatenburg de Jong RJ, 896Baay MFD, 410Babidge WJ, 641Bain B, 1054Bain BJ, 189 (L), 501 (L)Baker A, 1002Balfour AH, 908Ballestin C, 351Banerjee SS, 37, 245Banks RE, 179Barbara L, 1117Bardham KD, 91 (C)Barnett D, 186 (C)Baron DN, 187 (C)Barr JG, 912Barrett SP, 706Barron JL, 463Barry M, 556Bartl R, 477Barton SA, 493Barton SE, 885 (L)Bateman AC, 781Bates CJ, 667Bauer HM, 415Bauters F, 548Baxter KJ, 849Beck JS, 304Beckett GJ, 771Becx MJCM, 250Beer TW, 596 (C)Begg N, 206Bellini C, 519Beltrami CA, 682Benbow EW, 120Bendon RW, 420Bennett JH, 950Bernardi F, 548Bemardi P, 856Bemards AT, 990Betta PG, 856Beuzelin-Yvraut M, 433Bharucha H, 275, 840, 1141Bhatnagar S, 589Biddolph SC, 239Billson V, 1057Birch PJ, 672Birembaut P, 295

Biselli R, 1117Bishop PW, 37Bisset DL, 245, 1059Blondeau JM, 710Boldorini R, 975Bolodeoku J, 463Booker DJ, 602Borg-Grech A, 589Botta M, 856Bouchier Hayes D, 84Bougaran J, 18Bouma G, 346Bourguignat A, 433Bowden SJ, 300Boxman ILA, 896Boyd JF, 883'(C)Brain AN, 1087Breathnach A, 670Bretagne JF, 749Brett M, 785 (C)Bridger JE, 59BrittonJA, 1051Bromley L, 424Broome U, 933Broomhead V, 89Brough WA, 592Brown JS, 300Brown KA, 525Browne RM, 300Buchanan R, 596 (C)Buchanan RC, 387Buchholz RFF, 408Buckley CH, 596 (C)Buist MR, 631Bunce M, 33Bunch C, 260Buntinx F, 408Burger MPM, 410Burke M, 287 (L), 1045BurnieJP, 183, 1130Burns J, 637Burton J, 840Buscher HCJL, 177Butlin SR, 304Buytaert Ph, 147

C

Caballero MD, 223Caballero T, 743Campbell CK, 807Cano D, 571Caracuel MD, 743Carbonell F, 835Carey FA, 616Carey PJ, 545Carneiro F, 787 (C)Carr NJ, 46Carroll SG, 368Carter CJ, 13Cartlidge PHT, 998Caselli M, 553Catovsky D, 189 (L), 835Caul EO, 779Caulet S, 749Cellini L, 1072Chadwick PR, 1068Chambers HM, 420Chan CM, 924Chan KS, 924Chan LC, 861Chan SY, 1022Chant PM, 807Chapel HM, 206, 260Chaperon J, 749Charles AK, 779Chau KY, 578Chau PY, 924Chen S-C, 7 (L)Cheng AFB, 775Cheong S-K, 796Chetty R, 239, 1035Chi DS, 662Chimera JA, 415Chiodini PL, 725Christeff N, 513Christopoulos C, 871Chu C-M, 470Chua A, 133Chui DHK, 861Chung LP, 1022Cimolai N, 488Cinti C, 330

Clark I, 1130Clarke R, 1141Clarke SC, 92 (L)Clarridge JE, 714Clavel C, 295Clemens MR, 291Clutterbuck DJ, 867Coad NAG, 22Coghill G, 304Cohen BJ, 493Cohen-Knafo E, 826Coke AP, 183Colina F, 351Collins BJ, 308Collins N, 611Comley M, 1035Cook HT, 339Cook MG, 689 (C), 1098Cooper K, 393 (C), 786 (C)Copplestone JA, 482Copson ER, 525Corcoran GD, 725Corcuera MT, 57Cordone I, 955Cormican M, 203Cornish JM, 210Cornwell GG, 984 (L)Cosson A, 548Costagliola D, 513Cotton DWK, 398 (L), 497 (L)Covacci A, 41, 967Cowan C, 278Cowling P, 667Craanen ME, 218Crabtree JE, 41, 939, 967Cracknell SE, 1137Crawford DH, 287 (L)Crawford S, 706Creagh T, 59Cree IA, 304Cristina S, 975Crocker J, 539Crook M, 587Cross SS, 402Crouch CF, 652Crusius JBA, 376Cubitt WD, 904Cunningham R, 575Curran T, 7 (L)Cuthbert RJG, 257

DDainelli B, 1072D'Amelio R. 1117Danielsson A, 933Darbyshire PJ, 1051Darmton SJ, 539, 1064Davey KG, 807Davidson AGF, 488Davidson GA, 717Davies DR, 33Davies JD, 737Davies JM, 308Dawson AJ, 998De Angelis C, 519de Angelis ML, 415de Bruijn HWA, 410de Castro S, 223de Koning RW, 250de Maertelaer V, 318de Paco-Moya M, 579De Pauw BE, 474de Roda Husman A-M, 728De Siati L, 519De Silva CE, 110de Sola C, 743De Vuyst P, 318Deans GT, 592DeCarlo L, 553Defize J, 376Delsol G, 826Denton J, 229Denton K, 785 (C)DeRoux SJ, 965Desakorn V, 174Desselberger U, 168, 198Detre S, 876Deville WLJM, 346Dhillon AP, 1070Dickens A, 803Diebold J, 18Diehl V, 1009

Diss TC, 390, 1045Dixon MF, 939Dixon S, 1144Dogan A, 143Donna A, 856Downer CS, 807Dowsett M, 876Drucker DB, 929Dryburgh FJ, 1126Dufty JMK, 901Duk JM, 410Dukers DF, 438Dumortier P, 318Dunne FP, 300Dupond L, 548Durdey P, 272Durlach A, 295Durlach V, 295Duvall E, 616Dworkin MJ, 270Dye R, 616

EEarlam S, 270Echezarreta G, 1035Edwards C, 626Egglestone SI, 101Eichstaedt A, 291Eidt S, 1009El-Agnaf M, 275Elder E, 787 (C)Ellis IO, 981 (L)Elston CW, 981 (L)Erber WN, 308Erickson GA, 466Essed GGM, 408Evans CD, 22Evans DG, 714Evans DJ, 832Evans EGV, 210Evans J, 670Evans MF, 424Evans T, 91 (L)Eykyn SJ, 568

FFabbri M, 330Facchini A, 330Facon T, 548Fagan DG, 763Fahie-Wilson MN, 961Fan X-G, 133Fan X-J, 133Faraggiana T, 955Farina J, 351Farmery SM, 41Farrow M, 545Fasano L, 330Fateh-Moghadam A, 477Fatkenheuer G, 1009Faux JA, 260Fegan C, 105Ferec C, 531Ferguson DA, 662Ferrant A, 679Ferrari A, 955Ferri C, 519Ferry DR, 1064Filby C, 13Finato N, 682Firth JA, 402Fish DE, 59Flavell W, 1070Floretti G, 682Flynn J, 203FogginJJ, 1144Fonk JCM, 346Fonseca K, 214Foot ABM, 210Forbes GM, 308Fordy C, 270Fox H, 678Franqois M, 548Frankton A, 575Franzen C, 1009Fraser A, 908Freemont AJ, 229Frost RWP, 777Fukatsu A, 1093Fukuzawa Y, 1093

1148

Author index

GGaffney EF, 1017Gala JL, 679Galende J, 456Gilenzoski D, 710Gallagher HJ, 84Gallagher PJ, 781, 936Galloway MJ, 1144Galloway PJ, 372, 1126Garcia del Moral R, 743Garcia MA, 456Garcia-Talavera J, 835Gardner F, 584Gasbarrini G, 330Gates A, 257Gatter K, 1035Gatter KC, 239, 447Gaulard P, 18Gazet J-C, 164Gee JMW, 890 (L)Geraghty R, 168, 198Gevenois PA, 318Geyskens M, 147Gharakhanian S, 513Gibb AP, 717 -

Gibson BES, 1051Gilhus NE, 447Gillespie SH, 803Giroux M-A, 531Giubilei E, 955Gledhill A, 939Glennon M, 203Going JJ, 1028Goldin R, 880Goldsmith C, 912Gomez F, 57G6mez-Sanz R, 351Gondo T, 82Gonzalez M, 456Gonzalez-Pina B, 579Gonzalez-Villaron L, 223Goorney B, 658Gorguet B, 826GosneyJR, 1102Gosney MA, 1102Gosselin M, 749G6tz JM, 990Gouerou H, 531Gough D, 865Gough KR, 919Gould SJ, 420Gouldesbrough DR, 181Graham DY, 714Granger V, 186 (C)Gray E, 616Gray JJ, 168, 198, 908Green MA, 1098Greenberg J, 466Greenwald SE, 535Griesmacher A, 1039Griffiths H, 206, 260Grigolo B, 330Grimm M, 1039Groenier KH, 410Gii L, 160Guizzetti S, 975

HHi T, 662Haboubi NY, 226Hachem CY, 714Hagerstrand I, 933Hale RJ, 592Hall J, 545Hallal-Hachem H, 579Hann IM, 1051Hanninen ML, 92 (L)Harach HR, 185 (C)Hardwick RH, 129Hargreaves RM, 260Harmden P, 693 (L)Harris A, 575Harris G, 564Harris M, 37, 245Hashimura M, 1106Hashmi P, 383Hayashi I, 364Hayashi Y, 820Haye KR, 658Heath PK, 771Heatley M, 26, 323, 1031Hellemans P, 147Helmerhorst TJM, 728Hemrika DJ, 815Henry L, 690 (C)Herbrink P, 410Heresbach D, 749Herrington CS, 1 (L), 415Herrmann RP, 308Hiasa Y, 364Higgins G, 168, 198Hill SL, 719Hinchliffe RF, 594, 1137HinnieJ, 1126Ho BSW, 101

Ho C, 383Ho CM, 1022Ho PL, 924Ho-Yen DO, 64, 91 (L), 689 (C)Hoffbrand AV, 110Holt JM, 260Hoogkamp-Korstanje JAA, 474Hopman WPM, 250Hopwood V, 210Horny H-P, 291Horrevorts AM, 474Horstman A, 438Horton VA, 33Hoshii Y, 82Hourihane D, 61Hourihane DO'B, 335How T, 637Howe RA, 667Howie AF, 771Hoyland JA, 229Hrabok D, 710Hruban RH, 218Hubbard R, 1098Hunt CR, 120

Iaru T, 548Ibrahim KMA, 387Iglesias-Osma C, 223Ikeda Y, 137, 754Imbing F, 584Ip M, 775Iqbal A, 257Irving W, 575Isaacson M, 710Isaacson PG, 390, 395 (L), 873,

1045Ishihara T, 82Islam A, 686Itoh H, 820Itoh Y, 115Iwata T, 82Izydorczyk V, 548

JJackson P, 939Jackson PA, 1098Jackson PJ, 689 (C)Jackson SK, 105Jarnerot G, 933Jebakumar SPR, 658Jeffers M, 278Jenner K, 1064Jensen V, 429Jephcott AE, 919Jiwa NM, 438Johnson CP, 637Johnson EM, 210Johnson KH, 984 (L)Johnson PRE, 1005Johnston JI, 372Jones AW, 979 (C)Jones J, 493Jones M, 447Jones TJ, 22Joss AWL, 64, 91 (L), 689 (C)Joyce Wi, 84Juca NT, 351

KKaan JA, 810Kaiserling E, 291Kakumu S, 1093Kamakura T, 137, 754Kamiya M, 1093Kanavaros P, 18Karttunen R, 1111Karttunen T, 1111Kasahara T, 115Kashiwagi T, 82Kasuga M, 820Katoh K, 1093Kawai T, 115Kawashima H, 1093Kay H, 1075 (E)Kazem Y, 648Keeling PWN, 133Kelly C, 616Kenemans P, 631Kennedy GT, 912Kennedy SM, 946Kerbaol M, 749Kerola T, 1111Khan G, 845Khong TY, 420, 494Kinoshita M, 820Kitahori Y, 364Klepetko W, 1039Knottnerus JA, 408Knowles S, 420Knox WF, 120KoYC, 115Kobayashi S, 1093Koerner RJ, 1067Kokkini G, 871

Kolk AHJ, 810Kondratowicz GM, 1074 (C)Konishi N, 364Kopelman PG, 86Kuipers EJ, 376Kumar D, 584Kumar S, 584Kumar U, 880Kupek E, 59Kurban F, 990Kusano E, 115

LLaCorte R, 553Ladekarl M, 429Lagesson V, 979 (C)Lakhani SR, 164, 611Lam KY, 963Lamb D, 616Lambert JR, 969Lambkin HA, 883 (C)Lamers CBHW, 990Lamerz R, 477Lan J, 815Lauwers GY, 965Laws IM, 1070Lawton K, 385Le Berre N, 749Lea JR, 260Leader M, 84Lee AHS, 380Lee ASG, 424Lee D, 1005Lee L, 710Lee M, 260Leigh IM, 1087Leonard MB, 385Leone 0, 267Leung SY, 1022Levi M, 186 (C)Levine T, 496 (C)Lewin JF, 1070Lewis DA, 86Lewis WHP, 101Li C, 662Liang LN, 390Liaw Y-F, 470Lilleyman J, 1075 (E)LilleymanJS, 594, 1051, 1137Limb DI, 1122Lin HY, 75Lin SK, 969Lin YH, 75Linch D, 1045Lindley IJD, 41, 967Link H, 710Lo Y-MD, 33Lock C, 759Lombardi T, 759Loof L, 933Lopez-Berges MC, 456Lopez-Bravo A, 57Lopez-Macedo A, 456Loudon KW, 183Love SB, 849Lowe D, 1075 (E)Lowik CWGM, 896Ludlam CA, 867Lumbreras C, 351Luna A, 124Lunan CB, 278Lusher M, 658Luthra UK, 185 (C)Lye M, 1102Lynch DAF, 939

MMa DFF, 679McAdam KPWJ, 803McAlpine L, 490McBride H, 840McCarthy CJ, 61, 994McClean E, 768McClelland RA, 890 (L)McCluggage WG, 275, 840, 1141McDermott M, 61MacFarlane I, 385McGee JO'D, 415, 424Macgillivray F, 402MacGowan AP, 1067McGregor IL, 737Macheta MP, 181McIlroy J, 1126McIntyre M, 92 (L)McIntyre P, 168, 198McKee TA, 168, 198Mackey H, 768McMahon RFT, 120, 592McMullin MF, 787 (C)McWilliam U, 120Maehara Y, 137Magnani C, 856Mahrle G, 1009Maier U, 314Mainou-Fowler T, 482

Makunura CN, 737Malone M, 535Mandelli F, 955Mann JR, 22Marchini C, 682Mariuzzi L, 682Markey GM, 768Marks CG, 1098Marrano D, 267Martin-Bates E, 59Martin KM, 717Martin N, 18Martinez A, 124Martinez-Albadalejo M, 579Martinez JC, 151Martinez-Salmer6n FJ, 743Masi S, 955Mason CH, 869Mason DY, 18, 796Mateo MS, 151Mathers NJ, 398 (L), 497 (L)Matikainen M, 645Matsuda H, 364Matsumoto K, 364Matsushima K, 115Matthews HR, 539, 1064Mattila A, 645Matutes E, 194 (L), 835Maxwell P, 26, 840, 1031Mead GP, 1138Medina MT, 743Megran DW, 214Meher-Homji N, 368Mehtar S, 1082 (L)Meid JFGM, 474Meijer CJLM, 438, 631, 728, 815Meijer GA, 620Melcher D, 1002Meliconi R, 330Menegatti L, 1117Meroni L, 975Merridew SR, 509Metges J-P, 531Meuwissen SGM, 346, 376Michigishi T, 582Micklem K, 796Middledorp JM, 438Middleton PG, 672Midolo PD, 969Miettinen A, 645Mifsud AJ, 560Miglioli M, 1117Miguel-Garcia A, 835Miguel-Sosa A, 835Millard SH, 641Millis RR, 380Mills MJ, 961Mimori K, 754Minni F, 267Mire-Sluis AR, 525Mizukami Y, 582Moesner J, 878Mojiminiyi OA, 463Molina A, 571Molina Font JA, 571Mollo F, 856Molthoff CFM, 631Monaghan P, 164Monga G, 975Monihan JM, 46Monjardino J, 880Moody AH, 725Mooney EE, 242, 335Moore C, 971Moore CA, 763Moorghen M, 129Morena-Requena J, 579Moreno E, 351Morgan JI, 7 (L)Morgan L, 672Morgan MS, 915Morgan S, 383Mori M, 137, 754Morphopoulos G, 1059Morris AG, 539Morris JA, 929Morris TCM, 768Morrison AE, 867Mortimer PP, 490Morton D, 91 (C)Morton J, 424Mothersill C, 883 (C)Mourits-Andersen T, 878Mowbray MAS, 556Mravunac M, 250Muir KR, 22Mukaida N, 115Mulder AH, 177Mulder S, 810Muller A, 1009Muller MM, 1039Mufioz A, 571Mufioz E, 57Murakata LA, 46Murdoch DA, 1067

1149

Author index

Murphy MJ, 1126Murphy PG, 596 (C)Murphy WG, 717Musich PR, 662Muto S, 115Myers SR, 1087

NNaase MA, 845Nagvekar N, 447Nakamura S, 582Nash JQ, 493Navratil E, 18Navsaria HA, 1087Nduka N, 648Neeson PJ, 387Nelson J, 658Neuhold N, 314Nevado M, 351New NE, 37Newcom SR, 160Newcomb PV, 129Newell A, 885 (L)Newsom-Davis J, 447Ng IOL, 963NgWF, 1061Ng WK, 963, 1061Ni Riain Y, 203Nicholson RI, 890 (L)Nicolaides KH, 368Niemela S, 1111Nijevitch AA, 187 (C)Ninomiya T, 820Nisini R, 1117Niu J, 880Noel H, 679Noell H, 415Noguchi M, 582Nogueras F, 743Nonomura A, 582Noordhoek GT, 810Norton AJ, 883 (C)Norton R, 971Nousbaum J-B, 531Nunez EA, 513Nzeako UC, 46

0Oakhill A, 779, 1051Oakley KL, 1028Oates J, 626Odell EW, 759Offerhaus GJA, 218O'Hare MJ, 164Ohta K, 820Okayasu I, 1106O'Leary G, 946O'Leary JJ, 239Olsson R, 933O'Morain C, 61, 994O'Neill A, 242O'Neill AJ, 1017Ooi K, 1057Oppenheim BA, 1068Orazi A, 884 (C)Orchard G, 1011Orfao A, 151, 456Orradre JL, 151Osinaga E, 433Ostor AG, 1057Osuna E, 124Oudejans JJ, 438Oudkerk Pool M, 346

pPage LA, 525Pals G, 376Pan LX, 390, 1045Papadaki Th, 871Papapoulos SE, 896Parapia LA, 181Parker SP, 904Parkes SE, 22Parkinson MC, 693 (L)Parry JV, 490, 865Patel NR, 662Paz JI, 57Pearson TC, 525Peckham C, 904Pefia AS, 346, 376, 990Pennington TH, 64, 689 (C)Perez-Carceles MD, 124Perrone A, 519Perry S, 41Persaud CA, 568_Pescarmona E, 955Peters M, 98 (L)Pether JVS, 777Phelan L, 1054Phillips E, 433Phillips M, 466Phillips MJ, 186 (C)Pi DW, 13Pignoloni P, 955

Pinder SE, 981 (L)Pinkerton PH, 283 (L)Piris MA, 151Pitt MA, 226, 1059Pitt TL, 174Polak MM, 218Pollock L, 535Pollock LM, 86Ponder BAJ, 789 (L)Porter Hi, 779Porter WH, 179Pouli A, 1098Prentice AG, 482Prescott RJ, 245Prince HM, 387Properzi G, 519Prytz H, 933Puddle B, 950Puglisi F, 682Pulsatelli L, 330Purkis PE, 1087Pye A, 719

QQuirino T, 975

RRaboud JM, 13Radley AS, 545Raha-Chowdhury R, 763Rahimi S, 955Raju GC, 236Ralfkiaer E, 826Ramani P, 390Ramee MP, 749Rampling D, 535Ramsoekh TB, 218Randell J, 86Rappuoli R, 41, 967Rashid A-MH, 678Ratcliffe WA, 300Rattenbury JM, 771Rayner A, 564Raynes JG, 803Reade R, 548Rees A, 556Reeves DS, 1067Rege V, 463Rehman MTA, 229Reid C, 260Reilly JT, 186 (C)Reina J, 683Reynolds GM, 1138Rijs AJMM, 474Riley C, 1057Riley UBG, 706Risse EKJ, 728, 815Robaszkiewicz M, 531Rockett JC, 539Roddy S, 840Rodhain J, 679Rodrigo M, 743Rodrigues FC, 787 (C)Roediger WEW, 641Rogers M, 1054Roldan M, 57Ros MJ, 683Rose DSC, 676Roseto A, 433Rosin D, 880Roth CE, 168, 198Roue-Quintin I, 531Rowlands DC, 1138Rozenbaum W, 513Rubin A, 785 (C)Rubio CA, 1142Ruina M, 553Ruis Peris JM, 242Ruiz C, 571Russell EG, 969Russell NH, 257Russell Jones R, 1011Ryden B-O, 933

SSabas M, 466Saccani Jotti G, 876Saegusa M, 1106Saleh B, 648Salerno A, 689 (C)Salto-Tellez M, 616Salzberger B, 1009Samson J, 759Samson PD, 304San Miguel JF, 223, 456Sanchez-Beato M, 151Santini D, 267Santos M, 787 (C)Santucci A, 519Saul CA, 398 (L), 497 (L)Saunders PWG, 672Savige J, 785 (C)Sayers NM, 929

Scelsi M, 856Schambeck CM, 477Schipper MEI, 815Schlicker HUH, 291Schmitt FC, 53Schrappe M, 1009Schroijen V, 990Schweitzer DH, 896Scott FR, 1070Scott GV, 965Scraggs M, 637Selby PJ, 179Selves J, 826Serra A, 683Shafi MS, 560Shafighian B, 556Shanson D, 490Shaw RJ, 339Sheffield EA, 272Sheikh ZA, 185 (C)Shen-Schwarz S, 420Shepherd NA, 129, 849ShigaJ, 1106Shousha S, 950Shwe KH, 1005Siboni A, 878Side L, 961Sillis M, 493Simak R, 314Simson IW, 733Slater D, 690 (C)Slater DN, 95 (L), 405Slavik T, 733Slavin G, 1075 (E)Sloane JP, 164, 611Smellie WSA, 372, 1126Smith Di, 168, 198Smith JE, 908Smith JP, 466Smith MD, 174, 803Smith PH, 179Smith R, 1002Smith SR, 672Smolka A, 832Snijders PJF, 728So JCC, 861Sobala GM, 939Sobin LH, 46Sokol RJ, 602Soppi E, 645Sousa TR, 787 (C)Speirs GE, 1067Spencer J, 143, 395 (L), 873Spencer RC, 667Spickett GP, 89Stamps R, 602Staples A, 420Start RD, 398 (L), 402, 443, 497

(L)Staunton HA, 70Staunton MJ, 1017Stel HV, 728Stephenson JR, 383Stephenson PM, 936Stevens RF, 1051Stewart JH, 998Stewart M, 37Steyn RS, 1064Stickland JE, 424Stockley RA, 719Stolz E, 410Storey C, 658Stratton MR, 611Su SJ, 75Subedi AMC, 304Sugano M, 820Sugimachi K, 137, 754Suputtamongkol Y, 174Sutehall G, 168, 198Suvama SK, 443Swaminathan R, 587Sweeney E, 994Sweeney EC, 242

TTaberner DA, 901Tagaya T, 1093Tagesson C, 979 (C)Tait RC, 1005Takahashi K, 1093Takahashi M, 82Takano Y, 1106Takazakura E, 582Takiya S, 1093Tarin F, 835Taylor CJ, 771Taylor GM, 339Taylor MB, 904Teerawattanasook N, 174Teh M, 236Teixeira AV, 787 (C)Telfer TP, 380Telford DR, 929Temperton PF, 186 (C)

Teo JGC, 775ter Schegget J, 410Terracini B, 856Theaker JM, 869Thobie N, 513Thomas E, 662Thomas HC, 880Thomas JA, 287 (L)Thomas K, 690 (C)Thomas SM, 556Thurlow PJ, 387Tilanus HW, 177Toghill PJ, 257Tomlinson IPM, 424Tompkins DS, 41, 967Toner P, 26, 1031Toner PG, 275Tosswill J, 865Tovey DG, 725Trendell-Smith NJ, 272Trent R, 689 (C)Trevisani L, 553Trombley C, 488Troncone G, 415Trotta F, 553Turley H, 447Turner A, 919Turner RC, 33Tytgat GNJ, 250

UUberos J, 571Uguccioini M, 330Underwood JCE, 398 (L), 497

(L)

VVaira D, 1117Valenzuela A, 571Vallance DT, 70van Dam PA, 147van de Merwe JP, 346van den Berg FM, 218van den Brule AJC, 815Van der Putten HWHM, 408van der Stoop P, 376van der Valk P, 438van Es JM, 218Van Eyck SL, 415van Krieken JHJM, 896van Lanschot JJB, 177Van Marck E, 147van Oosterom AT, 147van Rensburg EJ, 789 (L)van Zyl H, 733Vazquez L, 223Veenendaal RA, 990Verschoor JSC, 250Verweij PE, 474Veselic M, 990Vidriales MB, 456Vieira DN, 124Ville Y, 368Vincenti AC, 781Vlavianos P, 871Vogl M, 1039Volant A, 531von Blomberg BME, 346Voorhorst Fl, 728Vos W, 438Vujanic GM, 998

WWaghom DJ, 358Wahl SJ, 965Walboomers J, 410Walboomers JMM, 438, 728, 815Walker B, 717Walker J, 335Walker MM, 832Waller JM, 832Wallerstedt S, 933Walsh AL, 174Walshaw L, 710Wang J, 873Wang ZD, 143Wangoo A, 339Warnock DW, 210, 807Warren BF, 272Warter A, 393 (C)Watanabe K, 973Watson ID, 385Watt B, 564, 701 (L)Watts M, 1045Wee A, 236Wehrmann M, 291Weissglas MG, 896Weller RO, 1078 (L)Wells CA, 737Wells S, 245, 1059Westermark P, 984 (L)Westwood NB, 525Wheat PF, 1122Whelan P, 179

1150

Author index

Whetstone R, 168, 198White NJ, 174Whiteside C, 26, 840, 1031Whittaker JA, 105Whyte KF, 91 (L)Wick M, 477Wilcox AH, 463Wilke H, 810Wilkin HJ, 787 (C)Wilkins MJ, 59Willcox N, 447Williams EJ, 509Wilson DV, 509Wilson P, 86Wilson TS, 689 (C)

Wilson Jones E, 1011Wmder AF, 70Wmehouse J, 164Wmstanley TG, 1122Wmter C, 513Wirbel E, 513Witteman EM, 250Wolfaardt M, 733Wong KC, 101Wong LTK, 488Wong MP, 578, 1022Wonke B, 110Worwood M, 763Woyke S, 185 (C)Wreghitt TG, 168, 198, 908

Wu HH, 75Wuthiekanun V, 174Wynne Jones J, 777

x

Xiang Z, 41, 967

yYagihashi N, 973Yagihashi S, 973Yam WC, 924Yamagishi Y, 115Yaschuk Y, 710Yelitcheva ZM, 187 (C)

Yeomans P, 737Yemault J-C, 318Yoon S, 820Young N, 667Yuen KY, 924Yuen ST, 578, 1022Yuoh G, 584

zZaitoun AM, 323Zandecki M, 548Zanelli M, 267Zanen J, 318Zelger B, 1011Zhang YW, 908

1151

Volume 48 * Subject index

AAcute leukaemia, QBEND10 for the diagnosis of

myelodysplastic syndromes in routinely processed bone marrowbiopsy specimens, 291: correspondence, 884

Acute myeloblastic leukaenia, Light scatter characteristicsof blast cells in acute myeloid leukaemia: association withmorphology and immunophenotype, 456

Adenocarcinomac-erbB-2 overexpression in the dysplasia/carcinoma sequence of

Barrett's oesophagus, 129Clear cell adenocarcinoma of the colon, 1142Dieulafoy's disease associated with early gastric cancer, 267Gastric polyposis caused by multiple carcinoids and early

carcinoma, 589OV 632 and MOC 31 in the diagnosis of mesothelioma and

adenocarcinoma: an assessment of their use in formalin fixedand paraffin wax embedded material, 626

Adenoma, Relation between stage, grade, proliferation, andexpression of p53 and CD44 in adenomas and carcinomas ofcolorectum, 1098

Adenomyomatosis, Papillary mucinous adenoma arising inadenomyomatous hyperplasia of the gall bladder, 965

Adenomyomatous hyperplasia, Papillary mucinous adenomaarising in adenomyomatous hyperplasia of the gall bladder, 965

Adenovirus, Fatal adenovirus 32 infection in a bone marrowtransplant recipient, 779

Adhesion molecules, Soluble forms of the adhesion moleculeE-cadherin in urine, 179

Adipose tissue, Immunohistochemical identification of tumoursof adipocytic differentiation using an antibody to aP2 protein,950

Aeromonas sp, Taxonomical and epidemiological investigationsof Aeromonas sp: correspondence, 92

Agar based media, Comparison of agar based media for primaryisolation of Helicobacter pylori, 714

Age, The age related amyloids: a growing family of uniquebiochemical substances, 984

Aggressive angiomyxoma, Angiomyxoid tumour in the renalperipelvic tissues with features of aggressive angiomyxoma, 82

AIDSAcute hepatic and renal failure caused by Pneumocystis carinii

in patients with AIDS, 975Lesser known mycobacteria: leader, 701

Algorithm, Microbiological investigation of polyarthralgia, 777Allograft, Epidermal differentiation and dermal changes in

healing following treatment of surgical wounds with sheets ofcultured allogeneic keratinocytes, 1087

Alpha-fetoprotein, Elevated serum alpha-fetoprotein in a patientwith undifferentiated carcinoma of the gall bladder, 1061

Amniocentesis, Concentration offetal plasma and amniotic fluidinterleukin-1 in pregnancies complicated by preterm prelabouramniorrhexis, 368

Amplityping, IS6110 based amplityping assay and RFLPfingerprinting of clinical isolates of Mycobacterium tuberculosis,924

Amyloid tumour, Amyloid tumour of the colon, 592Amyloids, The age related amyloids: a growing family of unique

biochemical substances, 984Androgens, Differences in androgens of HIV positive patients

with and without Kaposi sarcoma, 513Angiodysplasia, An unusual case of colonic angiodysplasia, 272Angiomyxoma, Angiomyxoid tumour in the renal peripelvic

tissues with features of aggressive angiomyxoma, 82Anogenital cancers, p53 in human papillomavirus associated

anogenital cancers: correspondence, 393Antibody(ies)

Antibodies to human papillomavirus type 16 E7 related toclinicopathological data in patients with cervical carcinoma,410

Leukaemia immunophenotyping: effect of antibody source andfluorochrome on antigen detection: correspondence, 186

Spectrotypic analysis of antibodies to Helicobacter pylori inpatients with antral gastritis and duodenal ulcer, 1117

Use of dried blood spots for the detection and confirmation ofHTLV-1 specific antibodies for epidemiological purposes, 904

AnticoagulantsEvaluation of anticoagulant control in a pharmacist operated

anticoagulant clinic, 545Introduction ofcomputer assisted control oforal anticoagulation

in general practice, 1144Anticomplementary activity, Anticomplementary activity inserum samples from patients with acute parvovirus B 19infection, 493

AntigenDetection of Chlamydia trachomatis antigen by enzymeimmunoassay: importance of confirmatory testing, 214

Latex agglutination for rapid detection of Pseudomonaspseudomallei antigen in urine of patients with melioidosis, 174

Antigen expression, Distribution of OV-TL 3 and MOv18 innormal and malignant ovarian tissue, 631

Antigen test, Use of the Pastorex aspergillus antigen latexagglutination test for the diagnosis of invasive aspergillosis, 210

Antigenaemia, Antigenaemia during acute graft versus hostdisease, 105

Antigliadin antibodies, Antigliadin antibody measurement bychemiluminescence ELISA in the diagnosis of coeliac disease,509

Antimicrobial susceptibility, Quality assessment of MicrobeBase antimicrobial susceptibility data, 1122

Antineutrophil cytoplasmic antibodiesEffect of proctocolectomy on serum antineutrophil cytoplasmic

antibodies in patients with chronic ulcerative colitis, 645Formalin fixation and pattems of antineutrophil cytoplasmic

antibodies, 89Antiserum, Detection of Ki67 antigen by a new sheep polyclonal

antiserum, 1138Antral gastritis, Spectrotypic analysis ofantibodies to Helicobacter

pylon in patients with antral gastritis and duodenal ulcer, 1117Antral mucosa, Early ultrastructural changes of antral mucosa

with aspirin in the absence of Helicobacter pyloni, 994ap2 protein, Immunohistochemical identification of tumours of

adipocytic differentiation using an antibody to aP2 protein, 950API 20C, Evaluation ofthe AUXACOLOR system, a new method

of clinical yeast identification, 807API-Campy System, Evaluation of the API-Campy System in

the biochemical identification of hippurate negativecampylobacter strains isolated from faeces, 683

Apocrine metaplasia, Apocrine adenosis: a precursor ofaggressive breast cancer?, 737

Apolipoprotein E, Rapid and safe determination of humanapolipoprotein E genotypes by miniaturised SDS-PAGE in non-insulin dependent diabetes mellitus, 295

Apolipoproteins, Limited discriminant value of lipoprotein AI,lipoprotein Lp(a) and other lipoprotein particles in patients withand without early onset ischaemic heart disease, 70

ApoptosisApoptosis in the nervous system: new revelations: leader, 7Apoptotic and mitotic indices in malignant melanoma and basal

cell carcinoma, 242Effect of interleukins on the proliferation and survival of B cell

chronic lymphocytic leukaemia cells, 482In situ end-labelling, light microscopic assessment and

ultrastructure of apoptosis in lung carcinoma, 1017Role oftransforming growth factor betal on hepatic regenerationand apoptosis in liver diseases, 1093

Appendix, Combined goblet cell carcinoid and mucinouscystadenoma of the appendix, 869

Arthritis, Acute gonococcal arthritis: an unusual host andpathogen combination, 86

Arthropathy, Anticomplementary activity in serum samples frompatients with acute parvovirus B19 infection, 493

Arthroscopy, Histological changes associated with an artificialanterior cruciate ligament, 556

Artificial RFLP PCR, HLA typing for DR3 and DR4 usingartifical restriction fragment length polymorphism PCR fromarchival DNA, 33

1152 I Clin Pathol 1995;48:1152-1166

Subject index

Aspergillosis, Clinical evaluation and reproducibility of thePastorex Aspergillus antigen latex agglutination test fordiagnosing invasive aspergillosis, 474

Aspergillus"Pseudoclusters" and typing by random amplification ofpolymorphic DNA of Aspergillusfumigatus, 183

Use of the Pastorex aspergillus antigen latex agglutination testfor the diagnosis of invasive aspergillosis, 210

Aspirin, Early ultrastructural changes of antral mucosa withaspirin in the absence of Helicobacter pylon, 994

Atypical ductal hyperplasia, Atypical ductal hyperplasia ofthe breast: clonal proliferation with loss of heterozygosity onchromosomes 16q and 17p, 611

AuditAudit of an emergency biochemistry service, 1126Audit oftumour histopathology reviewed by a regional oncology

centre, 245Audit of tumour pathology reviewed by a regional oncology

centre: correspondence, 690Blood bank audit: leader, 283Can histopathologists diagnose bronchopneumonia?, 120Internal audit in a microbiology laboratory, 560Laboratory turnround time: closing the loop, 372Multifactorial audit of invasive cervical cancer: key lessons for

the National Screening Programme, 405: correspondence, 785Perinatal and infant postmortem examinations: how well are we

doing?, 998Prospective audit of mucosal biopsy specimens of the

gastrointestinal tract, 936Review ofa consultant microbiologist's work practice - an audit:

leader, 1082Autoantibodies, Detection of autoantibodies to neutrophil

cytoplasmic antigens: correspondence, 785Autoimmune haemolytic anaemia, Investigation of patients

with autoimmune haemolytic anaemia and provision of bloodfor transfusion, 602

Automated blood count, Screening criterial for thalassaemiatrait in pregnant women, 1054

Autopsy, Public perceptions of necropsy: leader, 497AUXACOLOR, Evaluation of the AUXACOLOR system, a newmethod of clinical yeast identification, 807

Avidity, Avidity ofspecific IgG antibodies elicited by immunisationagainsts Haemophilus influenzae type b, 206

BB cell leukaemia, Effect of interleukins on the proliferation and

survival of B cell chronic lymphocytic leukaemia cells, 482B cell lymphoma

Clinicopathologic implications of Epstein-Barr virus related Bcell lymphoma in immunocompromised patients: leader, 287

Immunohistochemical analysis ofT cell proliferation in normaltonsil and B cell lymphoma, 873

B cell phenotype, Immunophenotypic analysis of childhoodBurkitt's lymphoma in the West Midlands 1957-1986, 22

BacT/AlertDetection ofbacteraemia by the continuously monitoring BacT/

Alert system, 912Growth and detection of filamentous fungi in the BacT/Alertblood culture system, 670

BacteraemiaBacteraemia caused by Campylobacter spp: correspondence, 596Detection ofbacteraemia by the continuously monitoring BacT/

Alert system, 912Bacteria, Simple method for quantifying viable bacterial numbers

in sputum, 719Barrett's oesophagus, c-erbB-2 overexpression in the dysplasia/

carcinoma sequence of Barrett's oesophagus, 129Basal cell carcinoma, Apoptotic and mitotic indices in malignantmelanoma and basal cell carcinoma, 242

bcl-2 protein expressionExpression of the bcl-2 protein in B cell lymphomas arisingfrom mucosa associated lymphoid tissue, 18

Immunohistochemical detection of p53 and Bcl-2 proteins inHashimoto's thyroiditis and primary thyroid lymphomas, 239

p53, Rb and bcl-2 expression during the cell cycle: a study inphytohaemagglutinin stimulated lymphocytes and microwaveirradiated lymphoid tissue sections, 151

Biochemical variables, Variation in serum electrolytes andenzyme concentrations in patients with sickle cell disease, 648

BiopsyDistribution of cervical intraepithelial neoplasia: are

hysterectomy specimens sampled appropriately?, 323

Prospective audit of mucosal biopsy specimens of thegastrointestinal tract, 936

Sampling variability of percutaneous liver biopsy in primarysclerosing cholangitis, 933

Bladder cancerPseudoangiosarcomatous carcinoma of the genitourinary tract,

1059Soluble forms of the adhesion molecule E-cadherin in urine,

179BloodA new, fast and convenient method for layering blood or bonemarrow over density gradient medium, 686

Rate of growth of Pseudomonasfluorescens in donated blood, 717Blood bank, Blood bank audit: leader, 283Blood cultureDo blood cultures need continuous monitoring so that clinical

action can be taken outside normal working hours?, 1067Documentation of blood culture results, 667Growth and detection of filamentous fungi in the BacT/Alertblood culture system, 670

Blood donors, Management of blood donors whose donationsare repeatedly falsely positive by the HIV antibody screeningtest, 865

Blood rheology, Relationship of blood rheology to lipoproteinprofile during normal pregnancies and those with intrauterinegrowth retardation, 571

Blood for transfusion, Investigation ofpatients with autoimmunehaemolytic anaemia and provision of blood for transfusion, 602

Bone marrowA new, fast and convenient method for layering blood or bonemarrow over density gradient medium, 686

Non-neoplastic glandular structures in bone marrow: a technicalartefact, 1141

QBEND1O for the diagnosis of myelodysplastic syndromes inroutinely processed bone marrow biopsy specimens, 291:correspondence, 884

Bone marrow biopsy, Detection ofmycobacteria in bone marrowbiopsy specimens taken to investigate pyrexia ofunknown origin,706

Bone marrow granulomas, Granulomatous bone marrowinflammation during treatment of chronic myeloid leukaemiawith interferon alpha-2b, 878

Bone marrow studies, Recurrent thrombotic occlusions ofarteries and veins caused by intravascular metastaticadenocarcinoma: correspondence, 186

Bone marrow transplantationFatal adenovirus 32 infection in a bone marrow transplant

recipient, 779Functional hyposplenism following allogeneic bone marrow

transplantation, 257Immunohistochemical changes in sigmoid colon after allogeneicand autologous bone marrow transplantation, 308

Bone marrow trephine biopsyB cell signet-ring cell lymphoma of bone marrow, 275Immunohistochemical staining of plastic embedded bonemarrow trephine biopsy specimens after microwave heating,840

Immunohistochemistry in apparently normal bone marrowtrephine specimens from patients with nodal follicularlymphoma, 1035

Book reviewsBeeching NJ, Cheesbrough JS. Infectious diseases. Illustrated

case histories, 281Dail DH, Hammar SP, editors. Pulmonary pathology, 2nd edn,

281Ehrmann RL. Benign to malignant progression in cervicalsquamous epithelium, 691

Epler GR, ediwr. Diseases of the bronchioles, 884Essex M, Mboup S, Kanki PJ, Kalengayi MR, editors. AIDS in

Africa, 281Gompel C, Silverberg SG, editors. Pathology in gynecology and

obstetrics, 4th edn, 94Heller DS. The endometrium. A clinicopathologic approach,

787Joshi VV. Common problems in pediatric pathology, 691Kaplan CG. Color atlas of gross placental pathology, 691Lack EE. Pathology of adrenal and extra-adrenal paraganglia.

Vol 29 in series Major problems in pathology, 281Leevy CM, Sherlock S, Tygstrum N, Zetterman R, editors.

Diseases of the liver and biliary tract: standardization ofnomenclature, diagnostic criteria, and prognosis, 393

1153

Subject index

Marchevsky AM, Bartels PH, editors. Image analysis: a primerfor pathologists, 691

Mason JK, editor. The pathology of trauma, 2nd edn, 93Nonnenmacher TF, Losa GA, Weibel ER, editors. Fractals in

biology and medicine, 93Pneumocystis carinii pneumonia. 2nd edn. Lung biology in healthand disease, 92

Saldana MJ, editor. Pathology of pulmonary disease, 93Scheuer PJ, Lefkowitch JH. Liver biopsy interpretation, 5th

edn. Vol 31 in series Major problems in pathology, 788Sekiguchi S, editor. Clinical application of leukocyte depletion,94

Taylor CR, Cote RJ. Immunomicroscopy: a diagnostic tool forthe surgical pathologist. Vol 19 in series Major problems inpathology, 281

Thatcher N, Spiro S, editors. New perspectives in lung cancer,93

Woodruff JD, Angtuaco TL, Parmley TH. Atlas of gynecologicpathology, 2nd edn, 690

Working party on human tissue chaired by Professor DameRosalinde Hurley. Human tissue: ethical and legal issues,1074

World Health Organisation. IARC Monographs on theevaluation of carcinogenic risks to humans, vol 59, hepatitisviruses, 691

Borderline abnormalities, Pathologist variation in reportingcervical borderline epithelial abnormalities and cervicalintraepithelial neoplasia, 59

Breast cancer (carcinoma)A "quickscore" method for immunohistochemical

semiquantitation: validation for oestrogen receptor in breastcarcinomas, 876

Apocrine adenosis: a precursor of aggressive breast cancer?, 737Atypical ductal hyperplasia of the breast: clonal proliferation

with loss of heterozygosity on chromosomes 16q and 17p,611

Immunohistochemical quantitation of oestrogen receptors andproliferative activity in oestrogen receptor positive breastcancer, 429

Immunohistochemical study of topoisomerase II-alphaexpression in primary ductal carcinoma of the breast, 147

Loss of heterozygosity on chromosome llq in breast cancer,424

Malignant myoepithelioma (myoepithelial carcinoma) of thebreast: a detailed cytokeratin study, 164

Metastatic breast carcinoma with appearance resemblingmicropapillary ductal carcinoma in situ, 380

Prognostic factors in primary breast carcinoma: leader, 981Specimen slice radiography of cancer in breast conserving

excisions, 1028Spectrum of carcinoembryonic antigen immunoreactivity from

isolated ductal hyperplasias to atypical hyperplasias associatedwith infiltrating ductal breast cancer, 53

Breast diseaseCytokeratin intermediate filament expression in benign and

malignant breast disease, 26Paget's disease of the breast: correspondence, 393

Breast-ovarian cancer, Molecular genetics of familial breast-ovarian cancer: leader, 789

Breath isoprene, Origins of breath isoprene: correspondence, 979Breath tests, Volatile organic compounds in the breath ofpatients

with schizophrenia, 466Brenner tumour, Brenner tumour of the vagina, 678Bronchial carcinoma

Orthostatic hypotension and vasodilatory peptides in bronchialcarcinoma, 1102

Osteolytic bone lesions in a patient with idiopathic myelofibrosisand bronchial carcinoma, 867

Bronchopneumonia, Can histopathologists diagnosebronchopneumonia?, 120

Burkholderia cepacia, Selective media for isolation ofBurkholderia (Pseudomonas) cepacia from the respiratorysecretions of patients with cystic fibrosis, 488

Burkitt's lymphoma, Immunophenotypic analysis of childhoodBurkitt's lymphoma in the West Midlands 1957-1986, 22

Cc-erbB-2, c-erbB-2 overexpression in the dysplasia/carcinoma

sequence of Barrett's oesophagus, 129C-polysaccharide, Detection of C-polysaccharide in serum of

patients with Streptococcus pneumoniae bacteraemia, 803

CagAHelicobacter pylori induced interleukin-8 expression in gastric

epithelial cells is associated with CagA positive phenotype,41

Induction of interleukin-8 secretion from gastric epithelial cellsby a cagA negative isogenic mutant of Helicobacter pylon, 967

Calcium binding, Hypercalcaemia due to calcium binding IgMparaprotein in Waldenstrom's macroglobulinaemia, 961

Campylobacter sppBacteraemia caused by Campylobacter spp: correspondence, 596Evaluation of the API-Campy System in the biochemical

identification of hippurate negative campylobacter strainsisolated from faeces, 683

Cancer, Steroid hormone receptors and their clinical significancein cancer: leader, 890

Carcinoembryonic antigen, Spectrum of carcinoembryonicantigen immunoreactivity from isolated ductal hyperplasias toatypical hyperplasias associated with infiltrating ductal breastcancer, 53

Carcinoid, Gastric polyposis caused by multiple carcinoids andearly carcinoma, 589

Carcinoma in situ, Specimen slice radiography of cancer inbreast conserving excisions, 1028

Cardiac myxoma, S100, alpha-smooth muscle actin andcytokeratin 19 immunohistochemistry in odontogenic and softtissue myxomas, 759

CD antigen, Activated phenotype in neutrophils and monocytesfrom patients with primary proliferative polycythaemia, 525

CD3 negative large granular lymphocytes, Longstandingproliferation of CD3 negative large granular lymphocytespreceding the development of high grade non-Hodgkin'slymphoma, 672

CD4, Lymphocyte subset counts in skin puncture and venousblood compared, 1137

CD8, Lymphocyte subset counts in skin puncture and venousblood compared, 1137

CD19, CDl9 and immunophenotype of bone marrow plasmacells in monoclonal gammopathy of undetermined significance,548

CD31, Immunostaining for CD31 and CD34 in Kaposi sarcoma,1011

CD34Immunostaining for CD31 and CD34 in Kaposi sarcoma, 1011QBEND1O for the diagnosis of myelodysplastic syndromes in

routinely processed bone marrow biopsy specimens, 291:correspondence, 884

CD44, Relation between stage, grade, proliferation, and expressionof p53 and CD44 in adenomas and carcinomas of colorectum,1098

Cell death, Apoptosis in the nervous system: new revelations:leader, 7

Cell proliferation, Detection of Ki67 antigen by a new sheeppolyclonal antiserum, 1138

Cellular immediate-early gene response, Apoptosis in thenervous system: new revelations: leader, 7

Central retinal vein thrombosis, Acquired protein S deficiencyin a patient with systemic lupus erythematosus causing centralretinal vein thrombosis, 387

Central venous catheter, Corynebacterium aquaticum septicaemiain a neutropenic patient, 971

Ceroid granuloma, Ceroid granulomas in the female genitalsystem, 1057

Cervical biopsy, Diagnosis of genital infection caused by humanpapillomavirus using in situ hybridisation: the importance ofthe size of the biopsy specimen, 57

Cervical cancerAntibodies to human papillomavirus type 16 E7 related to

clinicopathological data in patients with cervical carcinoma,410

Comparative analysis of human papillomavirus detection byPCR and non-isotopic in situ hybridisation, 415

Human papillomavirus in false negative archival cervical smears:implications for screening for cervical cancer, 728

Cervical cytology, Cervical cytology external and internal qualityassurance: a comparative appraisal: leader, 95

Cervical intraepithelial neoplasiaDistribution of cervical intraepithelial neoplasia: are

hysterectomy specimens sampled appropriately?, 323Pathologist variation in reporting cervical borderline epithelial

abnormalities and cervical intraepithelial neoplasia, 59

1154

Subject index

Cervical neoplasia, Human papillomaviruses and cervicalneoplasia. II. Interaction of HPV with other factors: leader, 1

Cervical screeningComposition of cervical smears in patients with and without a

cervical ectropion, 408Multifactorial audit of invasive cervical cancer: key lessons for

the National Screening Programme, 405: correspondence, 785Role ofre-screening ofcervical smears in internal quality control,

1002Cervix

Ceroid granulomas in the female genital system, 1057Detection of integrated human papillomavirus 16 DNA insquamous cell carcinoma of the cervix: correspondence, 393

Chemiluminescence, Antigliadin antibody measurement bychemiluminescence ELISA in the diagnosis of coeliac disease,509

Chemotherapy, Lack of correlation of P-glycoprotein expressionwith response to MIC chemotherapy in oesophageal cancer,1064

Childhood lymphoblastic leukaemia, Changes incytomorphology of childhood lymphoblastic leukaemia at thetime of disease relapse, 1051

Chinese, Seasonal variation in the necropsy incidence ofpulmonary thromboembolism in Hong Kong, 578

Chlamydia trachomatisChlamydia trachomatis and ectopic pregnancy: retrospective

analysis of salpingectomy specimens, endometrial biopsies,and cervical smears, 815

Detection of Chlamydia trachomatis antigen by enzymeimmunoassay: importance of confirmatory testing, 214

Duplex PCR system for simultaneous detection of Neisseriagonorrhoeae and Chlamydia trachomatis in clinical specimens,101

Value of screening for oro-pharyngeal Chlamydia trachomatisinfection, 658

Chondral damage, Histological changes associated with anartificial anterior cruciate ligament, 556

Chromogranin immunostaining, Chromogranin positive cellsin colorectal carcinoma and transitional mucosa, 754

ChromosomesAtypical ductal hyperplasia of the breast: clonal proliferation

with loss of heterozygosity on chromosomes 16q and 17p,611

Loss of heterozygosity on chromosome llq in breast cancer,424

Chronic lymphocytic leukaemiaEffect of interleukins on the proliferation and survival of B cell

chronic lymphocytic leukaemia cells, 482Renal failure in a patient with chronic lymphocytic leukaemia

treated with fludarabine, 181Cigarette smoking, Free radical activity in young adult cigarette

smokers, 385Cirrhosis, Waterhouse-Friderichsen syndrome complicatingprimary biliary sepsis due to Pasteurella multocida in a patientwith cirrhosis, 775

Clear cells, Clear cell adenocarcinoma of the colon, 1142Clinical virology, Internal quality assurance in a clinical virology

laboratory. I. Internal quality assessment, 168Coagulometer, Effect of thromboplastin and coagulometer

interaction on the precision of the International NormalisedRatio, 13

Coeliac diseaseAntigliadin antibody measurement by chemiluminescenceELISA in the diagnosis of coeliac disease, 509

Lymphocytic gastritis and associated small bowel disease: adiffuse lymphocytic gastroenteropathy?, 939

Pitfalls in diagnosing coeliac disease: correspondence, 787ColonAmyloid tumour of the colon, 592Clear cell adenocarcinoma of the colon, 1142

Colonic angiodysplasia, An unusual case of colonicangiodysplasia, 272

Colonocytes, Thiol methyltransferase activity in colonocytes anderythrocyte membranes, 641

Colorectal adenoma, Quantification of proliferative activity incolorectal adenomas by mitotic counts: relationship to degreeof dysplasia and histological type, 620

Colorectal biopsy specimens, Histological discrimination ofidiopathic inflammatory bowel disease from other types of colitis,749

Colorectal cancer (carcinoma)Amyloid tumour of the colon, 592Chromogranin positive cells in colorectal carcinoma and

transitional mucosa, 754Importance of hepatic artery node involvement in patients with

colorectal liver metastases, 270Relation between stage, grade, proliferation, and expression ofp53 and CD44 in adenomas and carcinomas of colorectum,1098

Commercial media, Enteric media: pre-poured or in-house?,568

Common variable immunodeficiency, Hodgkin's disease in apatient with common variable immunodeficiency, 871

Competitive RT-PCR, Quantitation of hepatitis C viral RNA inliver and serum samples using competitive polymerase chainreaction, 820

Computer assistance, Macroscopic assessment of pulmonaryemphysema by image analysis, 318

Computer assisted guidelines, Managing test demand byclinicians: computer assisted guidelines: leader, 98

Computerised image handling, Computerised image handlingin pathology: leader, 796

Conjunctiva, HPV type 16 in conjunctival and junctionalpapilloma, dysplasia, and squamous cell carcinoma, 1106

Consultant microbiologist, Review of a consultantmicrobiologist's work practice - an audit: leader, 1082

Contamination, Rate of growth of Pseudomonas fluorescens indonated blood, 717

Continuous ambulatory peritoneal dialysis, Specific increasein interleukin-8 concentrations in dialysis fluid of patients withperitonitis receiving continuous ambulatory peritoneal dialysis,115

Continuous monitoringDetection ofbacteraemia by the continuously monitoring BacT/

Alert system, 912Do blood cultures need continuous monitoring so that clinical

action can be taken outside normal working hours?, 1067Core analyses, Laboratory turnround time: closing the loop, 372Coronary artery bypass graft, Limited discriminant value of

lipoprotein AI, lipoprotein Lp(a) and other lipoprotein particlesin patients with and without early onset ischaemic heart disease,70

Coronary artery dissection, Sudden death from coronary arterydissection, 781

Correction, 1074Corynebacterium aquaticum, Corynebacterium aquaticum

septicaemia in a neutropenic patient, 971Crohn's disease

E-cadherin expression in intestinal epithelium, 143Histological discrimination of idiopathic inflammatory bowel

disease from other types of colitis, 749Intraepithelial and lamina propria leucocyte subsets in

inflammatory bowel disease: an immunohistochemical studyof colon and rectal biopsy specimens, 743

Relation of granulomas to lymphatic vessels in Crohn's disease,335

Serological markers to differentiate between ulcerative colitisand Crohn's disease, 346

Cruciate ligament, Histological changes associated with anartificial anterior cruciate ligament, 556

Crystal violet, Contamination of crystal violet in the Gram stainmethod: correspondence, 92

Cult-Dip Plus dip slide, Evaluation of the Cult-Dip Plus dipslide method for urinary tract infection, 710

Culture mediaCommercially available versus home produced egg media for

isolation of mycobacteria, 564Comparison of agar based media for primary isolation of

Helicobacter pylori, 714Culture negative endocarditis, Immunoblotting in the diagnosis

of culture negative endocarditis caused by streptococci andenterococci, 1130

Cyclophosphamide, Idiopathic granulomatous vasculitis:response to immunosuppressive therapy, 579

Cyclosporin A, Tissue polypeptide specific antigen for thedetection of lymphoproliferative diseases induced bycyclosporin, 1039

Cyst antigen, Serological reactivity against cyst and tachyzoiteantigens of Toxoplasma gondii determined by FAST-ELISA, 908

1155

Subject index

Cystic fibrosisSelective media for isolation of Burkholderia (Pseudomonas)

cepacia from the respiratory secretions of patients with cysticfibrosis, 488

Serum glutathione S-transferase B1 activity as an index of liverfunction in cystic fibrosis, 771

Cytodiagnosis, Cytodiagnosis and the necropsy, 443Cytokeratin

Cimentin and cytokeratin expression in nodular hyperplasia andcarcinoma of the prostate, 1031

Cytokeratin intermediate filament expression in benign andmalignant breast disease, 26

Malignant myoepithelioma (myoepithelial carcinoma) of thebreast: a detailed cytokeratin study, 164

Cytokeratin 19, S 100, alpha-smooth muscle actin and cytokeratin19 immunohistochemistry in odontogenic and soft tissuemyxomas, 759

Cytology, The clinical value of urinary cytology: 12 years ofexperience with 615 patients, 314

CytomegalovirusDetection of cytomegalovirus using PCR in serum from renal

transplant recipients, 575Histological diagnosis of cytomegalovirus hepatitis in liver

allografts, 351Cytoskeletal proteins, Cytokeratin intermediate filament

expression in benign and malignant breast disease, 26

D83D4 cancer, Immunocytological analysis of the Tn associated

antigen 83D4 in serous effusions from patients with cancer:comparison with Tn soluble glycoprotein, 433

Data, Quality assessment of Microbe Base antimicrobialsusceptibility data, 1122

Deferiprone, Changes in transferrin saturation after treatmentwith the oral iron chelator deferiprone in patients with ironoverload, 110

Delayed type hypersensitivity, Enhanced expression of type 1procollagen and transforming growth factor-beta in tuberculininduced delayed type hypersensitivity, 339

Density gradient dispenser, A new, fast and convenient methodfor layering blood or bone marrow over density gradientmedium, 686

Desmin, Desmin expression in rhabdomyosarcoma: influence ofthe desmin clone and immunohistochemical method, 535

Diabetes, HLA typing for DR3 and DR4 using artifical restrictionfragment length polymorphism PCR from archival DNA, 33

Dieulafoy's disease, Dieulafoy's disease associated with earlygastric cancer, 267

Dip slide, Evaluation of the Cult-Dip Plus dip slide method forurinary tract infection, 710

Diverticular disease, An unusual case of colonic angiodysplasia,272

DNA cytometry, Interobserver variation in cell selection forDNAimage cytometry, 616

Documentation, Documentation of blood culture results, 667Down syndrome, Transient abnormal myelopoiesis accompaniedby hepatic fibrosis in two infants with Down syndrome, 973

Dried blood spots, Use of dried blood spots for the detection andconfirmation of HTLV-1 specific antibodies for epidemiologicalpurposes, 904

Drug resistance, P-glycoprotein positive, drug resistant invasivelymphoepithelial thymoma: treatment response tochemotherapy with cyclosporin and quinine, 679

Drug therapy, Introduction of computer assisted control of oralanticoagulation in general practice, 1144

Dry latex agglutination test, A practical single sample dry latexagglutination test for Helicobacter pylori antibody detection, 969

Ductal hyperplasia, Spectrum of carcinoembryonic antigenimmunoreactivity from isolated ductal hyperplasias to atypicalhyperplasias associated with infiltrating ductal breast cancer, 53

Duodenal ulcer, Spectrotypic analysis of antibodies toHelicobacter pylori in patients with antral gastritis and duodenalulcer, 1117

Duplex PCR, Duplex PCR system for simultaneous detectionof Neisseria gonorrhoeae and Chlamydia trachomatis in clinicalspecimens, 101

Dyspepsia, Failure to detect Helicobacter pylon in nasal mucus inH. pylori positive dyspeptic patients, 1072

Dysplasialcarcinoma sequence, c-erbB-2 overexpression in thedysplasia/carcinoma sequence of Barrett's oesophagus, 129

EE-cadherin

E-cadherin expression in intestinal epithelium, 143Soluble forms of the adhesion molecule E-cadherin in urine,

179Ectopic pregnancy, Chlamydia trachomatis and ectopic

pregnancy: retrospective analysis of salpingectomy specimens,endometrial biopsies, and cervical smears, 815

Ectopic secretion, Orthostatic hypotension and vasodilatorypeptides in bronchial carcinoma, 1102

Editors, Editors on editors: editorial, 1075Egg media, Commercially available versus home produced eggmedia for isolation of mycobacteria, 564

Electron microscopy, Detection and identification ofgastrointestinal microsporidia using non-invasive techniques,725

Emergency laboratory, Audit of an emergency biochemistryservice, 1126

Endometriosis, Ceroid granulomas in the female genital system,1057

Endometrium, Necrobiotic granulomas of the urogenital system:correspondence, 185

Endothelin, Endothelin-I in idiopathic pulmonary fibrosis, 330Endothelin-1, Circulating endothelin-l concentrations in

patients with chronic hypoxia, 519Endotoxaemia, Antigenaemia during acute graft versus host

disease, 105Enhanced chenmiluinescence, Enzyme immunoassays for IgGand IgM antibodies to Toxoplasma gondii based on enhancedchemiluminescence, 652

Enteric media, Enteric media: pre-poured or in-house?, 568Enterobacteria, Lethal synergy between toxins of staphylococciand enterobacteria: implications for sudden infant deathsyndrome, 929

Enterococcus faecium, Neomycin blood agar as a selectivemedium for vancomycin resistant Enterococcus faecium, 1068

Enzyme immunoassay, Detection of Chlamydia trachomatisantigen by enzyme immunoasasay: importance of confirmatorytesting, 214

Enzyme-linked inmmunosorbent assayAntigliadin antibody measurement by chemiluminescenceELISA in the diagnosis of coeliac disease, 509

Diagnosis of Helicobacter pylon infection by specific gastricmucosal IgA and IgG pylori antibodies, 990

Management of blood donors whose donations are repeatedlyfalsely positive by the HIV antibody screening test, 865

Epidermal growth factor receptor, Oncogene proteins andproliferation antigens in thymomas: increased expression ofepidermal growth factor receptor and Ki67 antigen, 447

Epithelial cells, Induction of interleukin-8 secretion from gastricepithelial cells by a cagA negative isogenic mutant of Helicobacterpylon, 967

Epithelial damage, Improvement of gastric inflammation andresolution of epithelial damage one year after eradication ofHelicobacter pylori, 250

Epstein-Barr virusAssociation of Epstein-Barr virus with sinonasal angiocentric T

cell lymphoma, 946Clinicopathologic implications of Epstein-Barr virus related B

cell lymphoma in immunocompromised patients: leader, 287Down-regulation of Epstein-Barr virus nuclear antigen 1 in

Reed-Steinberg cells of Hodgkin's disease, 845Epstein-Barr virus associated lymphoproliferative disorder with

fatal involvement of the gastrointestinal tract in an infant,390

Immunohistochemical demonstration of different latentmembrane protein-1 epitopes of Epstein-Barr virus inlymphoproliferative diseases, 438

Lymphoepithelial carcinoma of the salivary gland: in situdetection of Epstein-Barr virus, 1022

Erythrocyte membranes, Thiol methyltransferase activity incolonocytes and erythrocyte membranes, 641

Escherichia coli, Evaluation of the Cult-Dip Plus dip slidemethod for urinary tract infection, 710

FFAB typing, Changes in cytomorphology of childhood

lymphoblastic leukaemia at the time of disease relapse, 1051Faecal specinens, Detection and identification of

gastrointestinal microsporidia using non-invasive techniques,725

1156

Subject index

Faeces, Evaluation of the API-Campy System in the biochemicalidentification of hippurate negative campylobacter strainsisolated from faeces, 683

Familial breast-ovarian cancer, Molecular genetics of familialbreast-ovarian cancer: leader, 789

FAST-ELISA, Serological reactivity against cyst and tachyzoiteantigens of Toxoplasma gondii determined by FAST-ELISA, 908

Ferrtin, Postmortem blood ferritin concentrations in suddeninfant death syndrome, 763

Fetomaternal haemorrhage, Flow cytometry in diagnosis andmanagement of large fetomaternal haemorrhage, 1005

Filamentous fungi, Growth and detection of filamentous fungiin the BacT/Alert blood culture system, 670

Fine needle aspiration cytology, Occult papillarymicrocarcinoma of the thyroid: a potential pitfall of fine needleaspiration cytology? Is it possible to avoid it?, correspondence,185

Florid granulomatosis, Gold granuloma after accidentalimplantation, 1070

Flow cytometryFlow cytometry in diagnosis and management of large

fetomaternal haemorrhage, 1005Plasma cell proliferation in monoclonal gammopathies:measurement using BU-1 antibody in flow cytometry andmicroscopy: comparison with serum thymidine kinase, 477

Fludarabine, Renal failure in a patient with chronic lymphocyticleukaemia treated with fludarabine, 181

Fluorescence antibody test, Comparison of three methods forculture confirmation of Neisseria gonorrhoeae strains currentlycirculating in the UK, 919

Fluorochrome, Leukaemia immunophenotyping: effect ofantibody source and fluorochrome on antigen detection:correspondence, 186

Follow up, Ten year follow up study of lymphocytic gastritis:further evidence on Helicobacter pylon as a cause of lymphocyticgastritis and corpus gastritis, 1111

Free radical markers, Free radical activity in young adultcigarette smokers, 385

Fungal infection, Iron metabolism and fungal infections inpatients with haematological malignancies, 223

GGalactomannan, Clinical evaluation and reproducibility of the

Pastorex Aspergillus antigen latex agglutination test fordiagnosing invasive aspergillosis, 474

Gall bladder, Papillary mucinous adenoma arising inadenomyomatous hyperplasia of the gall bladder, 965

Gangliocytic paraganglioma, Gastrointestinal haemorrhagefrom a jejunal gangliocytic paraganglioma, 84

Gastric biopsy, Effect of transport medium and transportationtime on culture of Helicobacter pylon from gastric biopsyspecimens: correspondence, 91

Gastric cancer (carcinoma)Absence ofpepsinogen A3 gene expression in the gastric mucosa

of patients with gastric cancer, 376Dieulafoy's disease associated with early gastric cancer, 267Neural invasion in gastric carcinoma, 137Tissue and serum pepsinogen I and II in gastric cancer identified

using immunohistochemistry and rapid ELISA, 364Gastric inflammation, Improvement of gastric inflammationand resolution of epithelial damage one year after eradicationof Helicobacter pylon, 250

Gastric mucosaHistological findings in gastric mucosa in patients treated with

non-steroidal anti-inflammatory drugs, 553Identification of parietal cells in gastric body mucosa withHMFG-2 monoclonal antibody, 832

Gastric polyposis, Gastric polyposis caused by multiplecarcinoids and early carcinoma, 589

Gastric tube ossification, Heterotopic ossification induced byhypoxia in a retrosternal gastric tube following transhiataloesophagectomy, 177

Gastric ulcers, Serosal reaction in chronic gastric ulcers: animmunohistochemical and ultrastructural study, 226

GastritisChemical gastritis induced by naproxen in the absence of

Helicobacter pyloni infection, 61Helicobacter pylori induced interleukin-8 expression in gastric

epithelial cells is associated with CagA positive phenotype,41

Induction of interleukin-8 secretion from gastric epithelial cellsby a cagA negative isogenic mutant of Helicobacter pylori, 967

The prevalence of lymphoid follicles in Helicobacter pyloriassociated gastritis in patients with ulcers and non-ulcerdyspepsia, 325

Gastrointestinal haemorrhage, Gastrointestinal haemorrhagefrom a jejunal gangliocytic paraganglioma, 84

Gastrointestinal tractEpstein-Barr virus associated lymphoproliferative disorder with

fatal involvement of the gastrointestinal tract in an infant, 390Prospective audit of mucosal biopsy specimens of the

gastrointestinal tract, 936Gel electrophoresis, Changes in transferrin saturation after

treatment with the oral iron chelator deferiprone in patientswith iron overload, 110

Gene expression, Absence of pepsinogen A3 gene expression inthe gastric mucosa of patients with gastric cancer, 376

General practice, Introduction of computer assisted control oforal anticoagulation in general practice, 1144

Genes, Apoptosis in the nervous system: new revelations: leader,7

Genitourinary tract, Pseudoangiosarcomatous carcinoma of thegenitourinary tract, 1059

Germ cell tumour, Langerhans' cell histiocytosis: possibleassociation with malignant germ cell tumour, 963

Glutathione S-transferase B1, Serum glutathione S-transferaseB1 activity as an index of liver function in cystic fibrosis, 771

Goblet cell carcinoid, Combined goblet cell carcinoid andmucinous cystadenoma of the appendix, 869

Gold dental alloy, Gold granuloma after accidental implantation,1070

Gonadotrophin releasing hormone analogue, Degenerativechanges in myometrium simulating diffuse leiomyomatosis aftertreatment with gonadotrophin releasing hormone analogue, 278

Graft versus host diseaseAntigenaemia during acute graft versus host disease, 105Immunohistochemical changes in sigmoid colon after allogeneicand autologous bone marrow transplantation, 308

Gram stain method, Contamination of crystal violet in the Gramstain method: correspondence, 92

GranulomaEffects of treatment on the histopathology of leprosy, 304Granulomatous bone marrow inflammation during treatment

of chronic myeloid leukaemia with interferon alpha-2b, 878Relation of granulomas to lymphatic vessels in Crohn's disease,

335Granulomatous synovitis, Histological changes associated withan artificial anterior cruciate ligament, 556

Granulomatous vasculitis, Idiopathic granulomatous vasculitis:response to immunosuppressive therapy, 579

Growth retardation, Relationship of blood rheology tolipoprotein profile during normal pregnancies and those withintrauterine growth retardation, 571

HHaematological malignancies, Iron metabolism and fungal

infections in patients with haematological malignancies, 223Haematological neoplasms, Routine and specialised techniques

in the diagnosis of haematological neoplasms: leader, 501Haemoglobin, Inaccurate haemoglobin estimation inWaldenstrom's macroglobulinaemia: correspondence, 787

Haemoglobin H inclusion bodies, Comparison ofhaemoglobinH inclusion bodies with embryonic , globin in screening foralpha thalassaemia, 861

Haemophilus influenzae, Avidity of specific IgG antibodieselicited by immunisation against Haemophilus influenzae type b,206

Haemopoietic malignancies, Contribution of immuno-phenotype in the diagnosis and classification of haemopoieticmalignancies: leader, 194

Hairy cell leukaemia, Diagnostic relevance of peripheral bloodimmunocytochemistry in hairy cell leukaemia, 955

Hashimoto's thyroiditis, Immunohistochemical detection ofp53 and Bcl-2 proteins in Hashimoto's thyroiditis and primarythyroid lymphomas, 239

Healthcare staff, Testing healthcare staff for infection with HIVand hepatitis: logistic and ethical considerations: leader, 885

Helicobacter pyloriChemical gastritis induced by naproxen in the absence of

Helicobacter pylori infection, 61

1157

Subject index

Comparison of agar based media for primary isolation ofHelicobacter pylori, 714

Diagnosis of Helicobacter pylori infection by specific gastricmucosal IgA and IgG pylori antibodies, 990

Early ultrastructural changes of antral mucosa with aspirin inthe absence of Helicobacter pylori, 994

Effect of transport medium and transportation time on cultureof Helicobacter pylori from gastric biopsy specimens:correspondence, 91

Failure to detect Helicobacter pylori in nasal mucus in H. pyloripositive dyspeptic patients, 1072

Helicobacter pylori induced interleukin-8 expression in gastricepithelial cells is associated with CagA positive phenotype,41

High prevalence of Helicobacter pylori in saliva demonstrated bya novel PCR assay, 662

Histological findings in gastric mucosa in patients treated withnon-steroidal anti-inflammatory drugs, 553

Improvement of gastric inflammation and resolution of epithelialdamage one year after eradication of Helicobacter pylori, 250

Increased gastric production of interleukin-8 and tumournecrosis factor in patients with Helicobacter pylori infection,133

Induction of interleukin-8 secretion from gastric epithelial cellsby a cagA negative isogenic mutant of Helicobacter pylori, 967

Intragastric urea hydrolysis in children infected with Helicobacterpylori: correspondence, 187

Lymphocytic gastritis and associated small bowel disease: adiffuse lymphocytic gastroenteropathy?, 939

Practical single sample dry latex agglutination test forHelicobacter pylori antibody detection, 969

Prevalence of lymphoid follicles in Helicobacterpylori associatedgastritis in patients with ulcers and non-ulcer dyspepsia, 325

Spectrotypic analysis of antibodies to Helicobacter pylori inpatients with antral gastritis and duodenal ulcer, 1117

Ten year follow up study of lymphocytic gastritis: furtherevidence on Helicobacter pylori as a cause of lymphocyticgastritis and corpus gastritis, 1111

Hepatic artery lymph node, Importance of hepatic artery nodeinvolvement in patients with colorectal liver metastases, 270

Hepatic failure, Acute hepatic and renal failure caused byPneumocystis carinii in patients with AIDS, 975

Hepatic fibrosis, Transient abnormal myelopoiesis accompaniedby hepatic fibrosis in two infants with Down syndrome, 973

Hepatic regeneration, Role of transforming growth factor beta 1on hepatic regeneration and apoptosis in liver diseases, 1093

HepatitisHistological diagnosis of cytomegalovirus hepatitis in liver

allografts, 351Testing healthcare staff for infection with HIV and hepatitis:

logistic and ethical considerations: leader, 885Hepatitis B, Membrane staining for hepatitis B surface antigenon hepatocytes: a sensitive and specific marker of active viralreplication in hepatitis B, 470

Hepatitis B surface antigen, Membrane staining for hepatitisB surface antigen on hepatocytes: a sensitive and specific markerof active viral replication in hepatitis B, 470

Hepatitis C virusHepatitis C virus replication in hepatocellular carcinoma, 880Quantitation ofhepatitis C viral RNA in liver and serum samples

using competitive polymerase chain reaction, 820Hepatocellular carcinoma

Hepatitis C virus replication in hepatocellular carcinoma, 880p53 expression in hepatocellular carcinoma in a population in

Singapore with endemic hepatitis B virus infection, 236Herpes simplex virus, Comparative studies of types 1 and 2

herpes simplex virus infection of cultured normal keratinocytes,75

Heterotopic ossification, Heterotopic ossification induced byhypoxia in a retrosternal gastric tube following transhiataloesophagectomy, 177

Histogenesis, Brenner tumour of the vagina, 678Histology

Effects of treatment on the histopathology of leprosy, 304The clinical value of urinary cytology: 12 years of experience

with 615 patients, 314Histomorphometric parameters, Histomorphometric

classification of postmenopausal osteoporosis: implications forthe management of osteoporosis, 229

HistopathologyJob description of MLSOs: correspondence, 1074

Public perception of histopathology: leader, 398HIV

Detection of mycobacteria in bone marrow biopsy specimenstaken to investigate pyrexia of unknown origin, 706

Differences in androgens of HIV positive patients with andwithout Kaposi sarcoma, 513

Lesser known mycobacteria: leader, 701Management of blood donors whose donations are repeatedly

falsely positive by the HIV antibody screening test, 865Retrospective determination of HIV-1 status by a PCR method

on paraffin wax embedded sections, 733Testing healthcare staff for infection with HIV and hepatitis:

logistic and ethical considerations: leader, 885Tissue diagnosis of intestinal microsporidiosis using a

fluorescent stain with Uvitex 2B, 1009HIV screening, False negative results in enzyme linkedimmunosorbent assays using synthetic HIV antigens, 490

HLA antigens, Expression of HIA-ABC, HLA-DR andintercellular adhesion molecule-I in oesophageal carcinoma,539

HLA typing, HLA typing for DR3 and DR4 using artificalrestriction fragment length polymorphism PCR from archivalDNA, 33

HLA-DR, Effects of treatment on the histopathology of leprosy,304

HMFG-2 monoclonal antibody, Identification of parietal cellsin gastric body mucosa with HMFG-2 monoclonal antibody,832

Hodgkin's diseaseDown-regulation of Epstein-Barr virus nuclear antigen 1 in

Reed-Stemnberg cells of Hodgkin's disease, 845Hodgkin's disease in a patient with common variable

immunodeficiency, 871Immunohistochemical demonstration of different latentmembrane protein-I epitopes of Epstein-Barr virus inlymphoproliferative diseases, 438

Transforming growth factor betal messenger RNA inReed-Stemnberg cells in nodular sclerosing Hodgkin's disease,160

HTLV-1, Use of dried blood spots for the detection andconfirmation of HTLV-I specific antibodies for epidemiologicalpurposes, 904

Human papillomavirusAntibodies to human papillomavirus type 16 E7 related to

clinicopathological data in patients with cervical carcinoma,410

Comparative analysis of human papillomavirus detection byPCR and non-isotopic in situ hybridisation, 415

Detection of integrated human papillomavirus 16 DNA insquamous cell carcinoma of the cervix: correspondence, 393

Diagnosis of genital infection caused by human papillomavirususing in situ hybridisation: the importance of the size of thebiopsy specimen, 57

HPV type 16 in conjunctival and junctional papilloma, dysplasia,and squamous cell carcinoma, 1106

Human papillomavirus in false negative archival cervical smears:implications for screening for cervical cancer, 728

Human papillomaviruses and cervical neoplasia. II. Interactionof HPV with other factors: leader, 1

p53 in human papillomavirus associated anogenital cancers:correspondence, 393

Physical state of human papillomavirus using non-isotopic insitu hybridisation: correspondence, 786

Human T cell lymphotropic virus type I, Use of dried bloodspots for the detection and confirmation of HTLV-1 specificantibodies for epidemiological purposes, 904

HypercalcaemiaHypercalcaemia due to calcium binding IgM paraprotein inWaldenstrom's macroglobulinaemia, 961

Parathyroid hormone related protein and interleukin-6 mRNAexpression in larynx and renal cell carcinomas fromnormocalcaemic and hypercalcaemic patients, 896

Hyperlipidaemia, Relationship of blood rheology to lipoproteinprofile during normal pregnancies and those with intrauterinegrowth retardation, 571

Hypobetalipoproteinaemia, Lipoprotein composition andserum Lp(a) lipoprotein in hypobetalipoproteinaemia, 587

Hypogammaglobulinaemia, Hodgkin's disease in a patient withcommon variable immunodeficiency, 871

Hyposplenism, Functional hyposplenism following allogeneicbone marrow transplantation, 257

1158

Subject index

Hypothyroidism, Thyroid autoantibodies and the response tothyrotropin releasing hormone in patients with subclinicalhypothyroidism, 463

HypoxiaCirculating endothelin- 1 concentrations in patients with chronic

hypoxia, 519Heterotopic ossification induced by hypoxia in a retrosternal

gastric tube following transhiatal oesophagectomy, 177Hysterectomy, Distribution of cervical intraepithelial neoplasia:

are hysterectomy specimens sampled appropriately?, 323

IIdiopathic pulmonary fibrosis, Endothelin-1 in idiopathicpulmonary fibrosis, 330

IgA, Diagnosis of Helicobacter pylon infection by specific gastricmucosal IgA and IgG pylori antibodies, 990

IgE, Specificity and usefulness of an IgE immunosorbentagglutination assay for toxoplasmosis, 64

IgG, Diagnosis of Helicobacter pylori infection by specific gastricmucosal IgA and IgG pylori antibodies, 990

IgG antibodies, Avidity of specific IgG antibodies elicited byimmunisation against Haemophilus influenzae type b, 206

IgM paraprotein, Hypercalcaemia due to calcium binding IgMparaprotein in Waldenstr6m's macroglobulinaemia, 961

Image analysis, Interobserver variation in cell selection for DNAimage cytometry, 616

Image handling, Computerised image handling in pathology:leader, 796

Image processing, Macroscopic assessment of pulmonaryemphysema by image analysis, 318

Immunoassay, Enzyme immunoassays for IgG and IgMantibodies to Toxoplasma gondii based on enhancedchemiluminescence, 652

Immunoblotting, Immunoblotting in the diagnosis of culturenegative endocarditis caused by streptococci and enterococci,1130

Immunocompromised patients, Clinicopathologic implicationsof Epstein-Barr virus related B cell lymphoma inimmunocompromised patients: leader, 287

InmunocytochemistryDiagnostic relevance of peripheral blood immunocytochemistry

in hairy cell leukaemia, 955Immunocytological analysis of the Tn associated antigen 83D4

in serous effusions from patients with cancer: comparisonwith Tn soluble glycoprotein, 433

IrmmunohistochemistryA "quickscore" method for immunohistochemical

semiquantitation: validation for oestrogen receptor in breastcarcinomas, 876

Desmin expression in rhabdomyosarcoma: influence of thedesmin clone and immunohistochemical method, 535

Detection of Ki67 antigen by a new sheep polyclonal antiserum,1138

Immunohistochemical study of topoisomerase II-alphaexpression in primary ductal carcinoma of the breast, 147

Immunohistochemistry in apparently normal bone marrowtrephine specimens from patients with nodal follicularlymphoma, 1035

p53 expression in hepatocellular carcinoma in a population inSingapore with endemic hepatitis B virus infection, 236

Pseudoangiosarcomatous carcinoma of the genitourinary tract,1059

QBEND10 for the diagnosis of myelodysplastic syndromes inroutinely processed bone marrow biopsy specimens, 291:correspondence, 884

Should superheating be used for immunohistochemistry?:correspondence, 883

ImmunophenotypeCD19 and immunophenotype of bone marrow plasma cells inmonoclonal gammopathy of undetermined significance, 548

Contribution of immunophenotype in the diagnosis andclassification of haemopoietic malignancies: leader, 194

Light scatter characteristics of blast cells in acute myeloidleukaemia: association with morphology andimmunophenotype, 456

Splenic lymphoma with circulating villous lymphocytes, 584Inumunophenotypic analysis, Immunophenotypic analysis of

childhood Burkitt's lymphoma in the West Midlands1957-1986, 22

InumunostainingImmunostaining for CD31 and CD34 in Kaposi sarcoma, 1011

Membrane staining for hepatitis B surface antigen onhepatocytes: a sensitive and specific marker of active viralreplication in hepatitis B, 470

In-house media, Enteric media: pre-poured or in-house?, 568In-situ end-labelling, In situ end-labelling, light microscopic

assessment and ultrastructure of apoptosis in lung carcinoma,1017

In situ hybridisationDiagnosis of genital infection caused by human papillomavirus

using in situ hybridisation: the importance of the size of thebiopsy specimen, 57

Fatal adenovirus 32 infection in a bone marrow transplantrecipient, 779

Physical state of human papillomavirus using non-isotopic insitu hybridisation: correspondence, 786

India ink, A rapid and safe method to fix India ink on specimenresection margins: correspondence, 689

Infant, Perinatal and infant postmortem examinations: how wellare we doing?, 998

Infection, Immunological factors and risk of infection in plateauphase myeloma, 260

Infectious disease, Serological testing in a microbiologylaboratory of specimens from patients with suspected infectiousdisease, 358

Inflammatory pseudotumour, Inflammatory pseudotumour oflymph nodes, 37

Intercellular adhesion molecule-1, Expression of HLA-ABC,HLA-DR and intercellular adhesion molecule-i in oesophagealcarcinoma, 539

Interferon, Granulomatous bone marrow inflammation duringtreatment of chronic myeloid leukaemia with interferon alpha-2b, 878

Interferon treatment, Quantitation of hepatitis C viral RNA inliver and serum samples using competitive polymerase chainreaction, 820

Interleukin-1, Concentration of fetal plasma and amniotic fluidinterleukin-1 in pregnancies complicated by preterm prelabouramniorrhexis, 368

Interleukin-6, Parathyroid hormone related protein andinterleukin-6 mRNA expression in larynx and renal cellcarcinomas from normocalcaemic and hypercalcaemic patients,896

Interleukin-8Helicobacter pylori induced interleukin-8 expression in gastric

epithelial cells is associated with CagA positive phenotype,41

Increased gastric production of interleukin-8 and tumournecrosis factor in patients with Helicobacter pylon infection,133

Induction of interleukin-8 secretion from gastric epithelial cellsby a cagA negative isogenic mutant of Helicobacter pylori, 967

Specific increase in interleukin-8 concentrations in dialysis fluidof patients with peritonitis receiving continuous ambulatoryperitoneal dialysis, 115

Interleukins, Effect of interleukins on the proliferation andsurvival of B cell chronic lymphocytic leukaemia cells, 482

Intermediate filament proteins, Cimentin and cytokeratinexpression in nodular hyperplasia and carcinoma of the prostate,1031

Intermediate filaments, Serosal reaction in chronic gastriculcers: an immunohistochemical and ultrastructural study, 226

Internal quality control, Internal quality assurance in a clinicalvirology laboratory. II. Internal quality control, 198

International Normalised Ratio, Effect of thromboplastin andcoagulometer interaction on the precision of the InternationalNormalised Ratio, 13

International Sensitivity Indexes (ISI), An easier alternative toorthogonal regression for calculation of International SensitivityIndexes, 901

Interobserver variationInterobserver variation in cell selection for DNA image

cytometry, 616Malignant mesothelioma of the pleura: interobserver variability,

856Intestinal biopsy, Intraepithelial and lamina propria leucocyte

subsets in inflammatory bowel disease: an immunohistochemicalstudy of colon and rectal biopsy specimens, 743

Intraepithelial lymphocytes, Lymphocytic gastritis andassociated small bowel disease: a diffuse lymphocyticgastroenteropathy?, 939

1159

Subject index

Intrauterine growth retardation, Relationship of bloodrheology to lipoprotein profile during normal pregnancies andthose with intrauterine growth retardation, 571

Intravascular metastatic adenocarcinoma, Recurrentthrombotic occlusions of arteries and veins caused byintravascular metastatic adenocarcinoma: correspondence, 186

Invasive aspergllosis, Use of the Pastorex aspergillus antigenlatex agglutination test for the diagnosis of invasive aspergillosis,210

Invasive thymoma, P-glycoprotein positive, drug resistantinvasive lymphoepithelial thymoma: treatment response tochemotherapy with cyclosporin and quinine, 679

Iron, Postmortem blood ferritin concentrations in sudden infantdeath syndrome, 763

Iron deficiency, Frequency of coincident iron deficiency andbeta-thalassaemia trait in British Asian children, 594

Iron metabolism, Iron metabolism and fungal infections inpatients with haematological malignancies, 223

Iron overload, Changes in transferrin saturation after treatmentwith the oral iron chelator deferiprone in patients with ironoverload, 110

IS6110, IS6110 based amplityping assay and RFLP fingerprintingof clinical isolates of Mycobacterium tuberculosis, 924

Isoprene, Origins of breath isoprene: correspondence, 979

JJejunum, Gastrointestinal haemorrhage from a jejunal

gangliocytic paraganglioma, 84

KK-ATPase, Identification of parietal cells in gastric body mucosa

with HMFG-2 monoclonal antibody, 832K-ras, Molecular markers for diagnostic cytology of neoplasms

in the head region of the pancreas: mutation of K-ras andoverexpression of the p53 protein product, 218

Kaposi sarcomaDifferences in androgens of HIV positive patients with andwithout Kaposi sarcoma, 513

Immunostaining for CD31 and CD34 in Kaposi sarcoma, 1011KBA.62, Production and characterisation of an antimelanomamonoclonal antibody KBA.62 using a new melanoma cell linereactive on paraffin wax embedded sections, 826

KeratinocytesComparative studies of types 1 and 2 herpes simplex virus

infection of cultured normal keratinocytes, 75Epidermal differentiation and dermal changes in healing

following treatment of surgical wounds with sheets of culturedallogeneic keratinocytes, 1087

Keratins, Epidermal differentiation and dermal changes in healingfollowing treatment of surgical wounds with sheets of culturedallogeneic keratinocytes, 1087

Ki67, Circulating Ki67 positive lymphocytes in multiple myelomaand benign monoclonal gammopathy, 835

Ki67 antigenDetection of Ki67 antigen by a new sheep polyclonal antiserum,

1138Oncogene proteins and proliferation antigens in thymomas:

increased expression of epidermal growth factor receptor andKi67 antigen, 447

Kleihauer technique, Flow cytometry in diagnosis andmanagement of large fetomaternal haemorrhage, 1005

LLaboratories

Internal audit in a microbiology laboratory, 560Laboratory turnround time: closing the loop, 372Perceptions of a medical microbiology service: a survey of

laboratory users, 915Laboratory use, Managing test demand by clinicians: computer

assisted guidelines:leader, 98Langerhans' cell histiocytosis, Langerhans' cell histiocytosis:possible association with malignant germ cell tumour, 963

Large intestine, Expression of proliferating cell nuclear antigenin hyperplastic polyps, adenomas and inflammatory cloacogenicpolyps of the large intestine, 46

Larynx cacinoma, Parathyroid hormone related protein andinterleukin-6 mRNA expression in larynx and renal cellcarcinomas from normocalcaemic and hypercalcaemic patients,896

Latent membrane protein-1, Immunohistochemicaldemonstration of different latent membrane protein-i epitopesof Epstein-Barr virus in lymphoproliferative diseases, 438

Latex agglutination, Latex agglutination for rapid detectionof Pseudomonas pseudomallei antigen in urine of patients withmelioidosis, 174

Leiomyomatosis, Degenerative changes in myometriumsimulating diffuse leiomyomatosis after treatment withgonadotrophin releasing hormone analogue, 278

Leprosy, Effects of treatment on the histopathology of leprosy,304

Leucocyte subsets, Intraepithelial and lamina propria leucocytesubsets in inflammatory bowel disease: an immunohistochemicalstudy of colon and rectal biopsy specimens, 743

LeukaemiaChanges in cytomorphology of childhood lymphoblastic

leukaemia at the time of disease relapse, 1051Contribution of immunophenotype in the diagnosis and

classification of haemopoietic malignancies: leader, 194Diagnostic relevance of peripheral blood immunocytochemistry

in hairy cell leukaemia, 955Effect of interleukins on the proliferation and survival of B cell

chronic lymphocytic leukaemia cells, 482Granulomatous bone marrow inflammation during treatment

of chronic myeloid leukaemia with interferon alpha-2b, 878Iron metabolism and fungal infections in patients with

haematological malignancies, 223Light scatter characteristics of blast cells in acute myeloid

leukaemia: association with morphology and immuno-phenotype, 456

QBEND10 for the diagnosis of myelodysplastic syndromes inroutinely processed bone marrow biopsy specimens, 291:correspondence, 884

Routine and specialised techniques in the diagnosis ofhaematological neoplasms: leader, 501

The leukaemic phase of non-Hodgkin's lymphoma: leader, 189Leukaemia immunophenotyping, Leukaemia immunopheno-

typing: effect of antibody source and fluorochrome on antigendetection: correspondence, 186

Light scatter, Light scatter characteristics of blast cells in acutemyeloid leukaemia: association with morphology andimmunophenotype, 456

Lipids, Limited discriminant value of lipoprotein AI, lipoproteinLp(a) and other lipoprotein particles in patients with and withoutearly onset ischaemic heart disease, 70

Lipoblast, Immunohistochemical identification of tumours ofadipocytic differentiation using an antibody to aP2 protein, 950

Lipofuscinosis, Ceroid granulomas in the female genital system,1057

Lipoprotein composition, Lipoprotein composition and serumLp(a) lipoprotein in hypobetalipoproteinaemia, 587

Lipoprotein profile, Relationship of blood rheology tolipoprotein profile during normal pregnancies and those withintrauterine growth retardation, 571

Liposarcoma, Immunohistochemical identification of tumoursof adipocytic differentiation using an antibody to aP2 protein,950

ithium, Histological features of the thyroid gland in a patientwith lithium induced thyrotoxicosis, 582

Liver biopsy, Sampling variability of percutaneous liver biopsyin primary sclerosing cholangitis, 933

Liver diseaseRole oftransforming growth factor betal on hepatic regeneration

and apoptosis in liver diseases, 1093Serum glutathione S-transferase B1 activity as an index of liver

function in cystic fibrosis, 771Liver metastases, Importance of hepatic artery node involvement

in patients with colorectal liver metastases, 270Liver transplant, Histological diagnosis of cytomegalovirus

hepatitis in liver allografts, 351Loss of heterozygosity

Atypical ductal hyperplasia of the breast: clonal proliferationwith loss ofheterozygosity on chromosomes 16q and 17p,611

Loss of heterozygosity on chromosome 11 q in breast cancer,424

Lp(a) lipoprotein, Lipoprotein composition and serum Lp(a)lipoprotein in hypobetalipoproteinaemia, 587

Lung cancer, Interobserver variation in cell selection for DNAimage cytometry, 616

1160

Subject index

Lung carcinoma, In situ end-labelling, light microscopicassessment and ultrastructure of apoptosis in lung carcinoma,-1017Lymph node

Inflammatory pseudotumour of lymph nodes, 37Retrospective determination of HIV-1 status by a PCR methodon paraffin wax embedded sections, 733

Lymphatic vessels, Relation of granulomas to lymphatic vesselsin Crohn's disease, 335

Lymphocyte subsets, Lymphocyte subset counts in skin punctureand venous blood compared, 1137

Lymphocytic gastritisLymphocytic gastritis and associated small bowel disease: a

diffuse lymphocytic gastroenteropathy?, 939Ten year follow up study of lymphocytic gastritis: further

evidence on Helicobacter pylon as a cause of lymphocyticgastritis and corpus gastritis, 1111

Lymphoepithelial carcinoma, Lymphoepithelial carcinoma ofthe salivary gland: in situ detection of Epstein-Barr virus, 1022

Lymphoid follicles, The prevalence of lymphoid follicles inHelicobacter pylori associated gastritis in patients with ulcers andnon-ulcer dyspepsia, 325

Lymphoid tissue, p53, Rb and bcl-2 expression during the cellcycle: a study in phytohaemagglutinin stimulated lymphocytesand microwave irradiated lymphoid tissue sections, 151

LymphomaAssociation of Epstein-Barr virus with sinonasal angiocentric T

cell lymphoma, 946Immunohistochemical analysis ofT cell proliferation in normal

tonsil and B cell lymphoma, 873The biology of low grade MALT lymphoma: leader, 395

Lymphoproliferation, Epstein-Barr virus associatedlymphoproliferative disorder with fatal involvement of thegastrointestinal tract in an infant, 390

Lymphoproliferative disorders, Routine and specialisedtechniques in the diagnosis ofhaematological neoplasms: leader,501

MMalignant mesothelioma, Malignant mesothelioma of the

pleura: interobserver variability, 856MALT lymphoma, Expression of the bcl-2 protein in B celllymphomas arising from mucosa associated lymphoid tissue, 18

Medical microbiology service, Perceptions of a medicalmicrobiology service: a survey of laboratory users, 915

Melanocytic naevi, Nuclear pseudoinclusions in melanocyticnaevi and melanomas, 676

MelanomaApoptotic and mitotic indices in malignant melanoma and basal

cell carcinoma, 242Nuclear pseudoinclusions in melanocytic naevi and melanomas,

676Production and characterisation of an antimelanomamonoclonal antibody KBA.62 using a new melanoma cellline reactive on paraffin wax embedded sections, 826

Melioidosis, Latex agglutination for rapid detection ofPseudomonas pseudomallei antigen in urine of patients withmelioidosis, 174

Mesenchymal tumour, Angiomyxoid tumour in the renalperipelvic tissues with features of aggressive angiomyxoma, 82

MesotheliomaMalignant mesothelioma of the pleura: interobserver variability,856

OV 632 and MOC 31 in the diagnosis of mesothelioma andadenocarcinoma: an assessment of their use in formalin fixedand paraffin wax embedded material, 626

Metastasis, Metastatic breast carcinoma with appearanceresembling micropapillary ductal carcinoma in situ, 380

Methylation, Thiol methyltransferase activity in colonocytes anderythrocyte membranes, 641

MHC class II antigens, Expression of MHC class II antigensby placental villi: no relationship with villitis ofunknown origin,494

MIB-1Immunohistochemical quantitation of oestrogen receptors and

proliferative activity in oestrogen receptor positive breastcancer, 429

Relation between stage, grade, proliferation, and expression ofp53 and CD44 in adenomas and carcinomas of colorectum,1098

Microbe Base data, Quality assessment of Microbe Baseantimicrobial susceptibility data, 1122

Microbiology, Review of a consultant microbiologist's workpractice - an audit: leader, 1082

Microbiology laboratory, Serological testing in a microbiologylaboratory of specimens from patients with suspected infectiousdisease, 358

Microbiology techniques, Internal audit in a microbiologylaboratory, 560

Micropapillary, Metastatic breast carcinoma with appearanceresembling micropapillary ductal carcinoma in situ, 380

Microscopic thymoma, Microscopic thymoma and myastheniagravis, 682

Microscopy, Routine urinalysis in renal transplant patients, 383Microsporidia, Detection and identification of gastrointestinal

microsporidia using non-invasive techniques, 725Microsporidiosis, Tissue diagnosis of intestinal microsporidiosis

using a fluorescent stain with Uvitex 2B, 1009Microwave heating, Immunohistochemical staining of plasticembedded bone marrow trephine biopsy specimens aftermicrowave heating, 840

Mitomycinlifosfamide/cisplatin, Lack of correlation of P-glycoprotein expression with response to MIC chemotherapy inoesophageal cancer, 1064

MitosisApoptotic and mitotic indices in malignant melanoma and basal

cell carcinoma, 242Quantification of proliferative activity in colorectal adenomasby mitotic counts: relationship to degree of dysplasia andhistological type, 620

MLSOs, Job description of MLSOs: correspondence, 1074MOC 31, OV 632 and MOC 31 in the diagnosis of mesotheliomaand adenocarcinoma: an assessment of their use in formalinfixed and paraffin wax embedded material, 626

Molecular genetics, Molecular genetics offamilial breast-ovariancancer: leader, 789

Monoclonal antibody(ies)Comparison of three methods for culture confirmation of

Neisseria gonorrhoeae strains currently circulating in the UK,919

Immunohistochemical demonstration of different latentmembrane protein-i epitopes of Epstein-Barr virus inlymphoproliferative diseases, 438

Monoclonal gammopathyCD19 and immunophenotype of bone marrow plasma cells inmonoclonal gammopathy of undetermined significance, 548

Plasma cell proliferation in monoclonal gammopathies:measurement using BU-1 antibody in flow cytometry andmicroscopy: comparison with serum thymidine kinase, 477

Monoclonal gammopathy of undetermined significance,Circulating Ki67 positive lymphocytes in multiple myeloma andbenign monoclonal gammopathy, 835

Monoclonality, The polymerase chain reaction in thedemonstration of monoclonality in T cell lymphomas, 1045

Monocyte activation, Activated phenotype in neutrophils andmonocytes from patients with primary proliferativepolycythaemia, 525

Monocyte esterase deficiency, Organophosphates andmonocyte esterase deficiency, 768: correction, 1074

MOv18, Distribution of OV-TL 3 and MOv18 in normal andmalignant ovarian tissue, 631

Mucinous adenoma, Papillary mucinous adenoma arising inadenomyomatous hyperplasia of the gall bladder, 965

Mucinous cystadenoma, Combined goblet cell carcinoid andmucinous cystadenoma of the appendix, 869

Mucosa associated lymphoid tissueExpression of the bcl-2 protein in B cell lymphomas arisingfrom mucosa associated lymphoid tissue, 18

The biology of low grade MALT lymphoma: leader, 395Mucosal biopsy specimens, Prospective audit of mucosal biopsy

specimens of the gastrointestinal tract, 936Multidrug resistanceLack of correlation of P-glycoprotein expression with response

to MIC chemotherapy in oesophageal cancer, 1064P-glycoprotein positive, drug resistant invasive lymphoepithelialthymoma: treatment response to chemotherapy withcyclosporin and quinine, 679

Multiple myelomaCD19 and immunophenotype of bone marrow plasma cells inmonoclonal gammopathy of undetermined significance, 548

1161

Subject index

Circulating Ki67 positive lymphocytes in multiple myeloma andbenign monoclonal gammopathy, 835

Muscular dystrophies, Recent advances in muscular dystrophiesand myopathies: leader, 597

Myasthenia gravisMicroscopic thymoma and myasthenia gravis, 682Oncogene proteins and proliferation antigens in thymomas:

increased expression of epidermal growth factor receptor andKi67 antigen, 447

MycobacteriaCommercially available versus home produced egg media for

isolation of mycobacteria, 564Detection of mycobacteria in bone marrow biopsy specimens

taken to investigate pyrexia of unknown origin, 706Lesser known mycobacteria: leader, 701Multiplex PCR for identifying mycobacterial isolates, 203

Mycobactenium tuberculosisIS6110 based amplityping assay and RFLP fingerprinting of

clinical isolates of Mycobacterium tuberculosis, 924Routine application of the polymerase chain reaction for

detection ofMycobacterium tuberculosis in clinical samples, 810Myelodysplasia, QBEND10 for the diagnosis of myelodysplastic

syndromes in routinely processed bone marrow biopsyspecimens, 291: correspondence, 884

Myelodysplastic syndromes, Routine and specialisedtechniques in the diagnosis of haematological neoplasms: leader,501

MyelofibrosisOsteolytic bone lesions in a patient with idiopathic myelofibrosisand bronchial carcinoma, 867

Transient abnormal myelopoiesis accompanied by hepaticfibrosis in two infants with Down syndrome, 973

Myeloma, Immunological factors and risk of infection in plateauphase myeloma, 260

Myeloproliferative disorders, Routine and specialisedtechniques in the diagnosis of haematological neoplasms: leader,501

Myocardial infarction, Biochemical assessment of acutemyocardial ischaemia, 124

Myoepithelial carcinoma, Malignant myoepithelioma(myoepithelial carcinoma) of the breast: a detailed cytokeratinstudy, 164

Myopathies, Recent advances in muscular dystrophies andmyopathies: leader, 597

Myxomas, S100, alpha-smooth muscle actin and cytokeratin 19immunohistochemistry in odontogenic and soft tissue myxomas,759

NNaproxen, Chemical gastritis induced by naproxen in the absence

of Helicobacter pylori infection, 61Nasal mucus, Failure to detect Helicobacter pylon in nasal mucus

in H. pylori positive dyspeptic patients, 1072Neck movement, A necropsy and histomorphometric study of

abnormalities in the course of the vertebral artery associatedwith ossified stylohyoid ligaments, 637

Necrobiotic granulomasNecrobiotic granulomas of the urogenital system: correspondence,

185, 690NecropsyCan histopathologists diagnose bronchopneumonia?, 120Cytodiagnosis and the necropsy, 443Have declining clinical necropsy rates reduced the contribution

of necropsy to medical research?, 402Perinatal and infant postmortem examinations: how well are we

doing?, 998Public perceptions of necropsy: leader, 497

Needle biopsy, Macroscopic examination of prostatic specimens:leader, 693

Neisseria gonorrhoeaeAcute gonococcal arthritis: an unusual host and pathogen

combination, 86Comparison of three methods for culture confirmation of

Neisseria gonorrhoeae strains currently circulating in the UK,919

Duplex PCR system for simultaneous detection of Neisseriagonorrhoeae and Chlamydia trachomatis in clinical specimens,101

Value of screening for oro-pharyngeal Chlamydia trachomatisinfection, 658

Neomycin blood agar, Neomycin blood agar as a selectivemedium for vancomycin resistant Enterococcus faecium, 1068

Neoplastic disease, Organophosphates and monocyte esterasedeficiency, 768: correction, 1074

Nervous system, Apoptosis in the nervous system: newrevelations: leader, 7

Neural invasion, Neural invasion in gastric carcinoma, 137Neutropenia, Corynebactenium aquaticum septicaemia in a

neutropenic patient, 971Neutrophil activation, Activated phenotype in neutrophils andmonocytes from patients with primary proliferativepolycythaemia, 525

Neutrophil cytoplasmic antigens, Detection of autoantibodiesto neutrophil cytoplasmic antigens: correspondence, 785

Nodal follicular lymphoma, Immunohistochemistry inapparently normal bone marrow trephine specimens frompatients with nodal follicular lymphoma, 1035

Nodular hyperplasia, Cimentin and cytokeratin expression innodular hyperplasia and carcinoma of the prostate, 1031

Non-Hodgkin's lymphomaLongstanding proliferation of CD3 negative large granular

lymphocytes preceding the development of high grade non-Hodgkin's lymphoma, 672

The leukaemic phase of non-Hodgkin's lymphoma: leader, 189Non-insulin dependendent diabetes mellitus, Rapid and safe

determination of human apolipoprotein E genotypes byminiaturised SDS-PAGE in non-insulin dependent diabetesmellitus, 295

Non-isotopic in situ hybridisation, Comparative analysis ofhuman papillomavirus detection by PCR and non-isotopic insitu hybridisation, 415

Non-neoplastic glandular structures, Non-neoplasticglandular structures in bone marrow: a technical artefact, 1141

Non-steroidal anti-inflammatory drugs, Histological findingsin gastric mucosa in patients treated with non-steroidal anti-inflammatory drugs, 553

Non-ulcer dyspepsia, The prevalence of lymphoid follicles inHelicobacter pylon associated gastritis in patients with ulcers andnon-ulcer dyspepsia, 325

Northern blotting, Chromogranin positive cells in colorectalcarcinoma and transitional mucosa, 754

Notices, 94, 187, 282, 394, 496, 596, 692, 788, 884, 980, 1074

0Observer reliability, Observer reliability in assessing placental

maturity by histology, 420Odontogenic myxoma, S100, alpha-smooth muscle actin and

cytokeratin 19 immunohistochemistry in odontogenic and softtissue myxomas, 759

Oesophageal carcinomaExpression of HLA-ABC, HIA-DR and intercellular adhesion

molecule-l in oesophageal carcinoma, 539Lack of correlation of P-glycoprotein expression with response

to MIC chemotherapy in oesophageal cancer, 1064Oesophageal neoplasma, p53 protein accumulation in

oesophageal squamous cell carcinomas and precancerouslesions, 531

Oesophagus, Heterotopic ossification induced by hypoxia in aretrostemal gastric tube following transhiatal oesophagectomy,177

Oestrogen receptorA "quickscore" method for immunohistochemical

semiquantitation: validation for oestrogen receptor in breastcarcinomas, 876

Immunohistochemical quantitation of oestrogen receptors andproliferative activity in oestrogen receptor positive breastcancer, 429

Oncogene expression, Apocrine adenosis: a precursor ofaggressive breast cancer?, 737

Oncogenes, Oncogene proteins and proliferation antigens inthymomas: increased expression of epidermal growth factorreceptor and Ki67 antigen, 447

Oncology centre, Audit of tumour histopathology reviewed bya regional oncology centre, 245

Oral anticoagulant therapy, An easier alternative to orthogonalregression for calculation of International Sensitivity Indexes,901

Oral mucosa, Gold granuloma after accidental implantation,1070

Organophosphates, Organophosphates and monocyte esterasedeficiency, 768: correction, 1074

1162

Subject index

Oro-genital contact, Value of screening for oro-pharyngealChlamydia trachomatis infection, 658

Orthogonal regression, An easier altemative to orthogonalregression for calculation of International Sensitivity Indexes,901

Orthostatic hypotension, Orthostatic hypotension andvasodilatory peptides in bronchial carcinoma, 1102

Ossified stylohyoid ligaments, A necropsy and histo-morphometric study of abnormalities in the course of thevertebral artery associated with ossified stylohyoid ligaments,637

Osteolytic lesions, Osteolytic bone lesions in a patient withidiopathic myelofibrosis and bronchial carcinoma, 867

Osteoporosis, Histomorphometric classification of postmeno-

pausal osteoporosis: implications for the management ofosteoporosis, 229

Out-of-hours service, Do blood cultures need continuousmonitoring so that clinical action can be taken outside normalworking hours?, 1067

OV 632, OV 632 and MOC 31 in the diagnosis of mesotheliomaand adenocarcinoma: an assessment of their use in formalinfixed and paraffin wax embedded material, 626

OV-TL 3, Distribution of OV-TL 3 and MOv18 in normal andmalignant ovarian tissue, 631

Ovarian carcinoma, Distribution of OV-TL 3 and MOv18 innormal and malignant ovarian tissue, 631

pp53

Immunohistochemical detection of p53 and Bcl-2 proteins inHashimoto's thyroiditis and primary thyroid lymphomas, 239

Molecular markers for diagnostic cytology of neoplasms inthe head region of the pancreas: mutation of K-ras andoverexpression of the p53 protein product, 218

p53, Rb and bcl-2 expression during the cell cycle: a study inphytohaemagglutinin stimulated lymphocytes and microwaveirradiated lymphoid tissue sections, 151

p53 expression in hepatocellular carcinoma in a population inSingapore with endemic hepatitis B virus infection, 236

p53 in human papillomavirus associated anogenital cancers:

correspondence, 393p53 protein accumulation in oesophageal squamous cell

carcinomas and precancerous lesions, 531Relation between stage, grade, proliferation, and expression ofp53 and CD44 in adenomas and carcinomas of colorectum,1098

P-glycoproteinLack of correlation of P-glycoprotein expression with response

to MIC chemotherapy in oesophageal cancer, 1064P-glycoprotein positive, drug resistant invasive lymphoepithelialthymoma: treatment response to chemotherapy withcyclosporin and quinine, 679

Paget's disease, Paget's disease of the breast: correspondence, 393Pancreatic cancer, Molecular markers for diagnostic cytology

of neoplasms in the head region of the pancreas: mutation ofK-ras and overexpression of the p53 protein product, 218

Papillary microcarcinoma of the thyroid, Occult papillarymicrocarcinoma of the thyroid: a potential pitfall of fine needleaspiration cytology? Is it possible to avoid it?: correspondence,185

Papilloma, HPV type 16 in conjunctival and junctional papilloma,dysplasia, and squamous cell carcinoma, 1106

Paraffin wax sectionsProduction and characterisation of an antimelanomamonoclonal antibody KBA.62 using a new melanoma cellline reactive on paraffin wax embedded sections, 826

Retrospective determination of HIV-1 status by a PCR methodon paraffin wax embedded sections, 733

Parathyroid hormone related proteinParathyroid hormone related protein and interleukin-6 mRNA

expression in larynx and renal cell carcinomas fromnormocalcaemic and hypercalcaemic patients, 896

Parathyroid hormone related protein in oral squamous cellcarcinomas invading the mandible, 300

Parietal cells, Identification of parietal cells in gastric bodymucosa with HMFG-2 monoclonal antibody, 832

Parvovirus B19, Anticomplementary activity in serum samplesfrom patients with acute parvovirus B19 infection, 493

PasteureUa multocida, Waterhouse-Friderichsen syndromecomplicating primary biliary sepsis due to Pasteurella multocidain a patient with cirrhosis, 775

Pastorex AspergiUus antigen test, Clinical evaluation andreproducibility of the Pastorex Aspergilus antigen latexagglutination test for diagnosing invasive aspergillosis, 474

Pattern recognition, Volatile organic compounds in the breathof patients with schizophrenia, 466

Pelvic recurrence, Influence of local peritoneal involvement onpelvic recurrence and prognosis in rectal cancer, 849

Pepsinogen, Absence of pepsinogen A3 gene expression in thegastric mucosa of patients with gastric cancer, 376

Pepsinogen I and II, Tissue and serum pepsinogen I and II ingastric cancer identified using immunohistochemistry and rapidELISA, 364

Pericardial fluid, Biochemical assessment of acute myocardialischaemia, 124

Perinatal, Perinatal and infant postmortem examinations: howwell are we doing?, 998

Peritoneal dialysis, Specific increase in interleukin-8concentrations in dialysis fluid of patients with peritonitisreceiving continuous ambulatory peritoneal dialysis, 115

Peritoneal involvement, Influence of local peritonealinvolvement on pelvic recurrence and prognosis in rectal cancer,849

Peritonitis, Specific increase in interleukin-8 concentrations indialysis fluid of patients with peritonitis receiving continuousambulatory peritoneal dialysis, 115

Pharmacists, Evaluation of anticoagulant control in a pharmacistoperated anticoagulant clinic, 545

Placental maturity, Observer reliability in assessing placentalmaturity by histology, 420

Placental pathology, Expression of MHC class II antigens byplacental villi: no relationship with villitis of unknown origin,494

Plastic embedding, Immunohistochemical staining of plasticembedded bone marrow trephine biopsy specimens aftermicrowave heating, 840

Plateau phase myeloma, Immunological factors and risk ofinfection in plateau phase myeloma, 260

Pleura, Malignant mesothelioma of the pleura: interobservervariability, 856

Pneumocystis carinii, Acute hepatic and renal failure causedby Pneumocystis carinii in patients with AIDS, 975

Pneumocystis caninii pneumonia, Routine diagnosis ofPneumocystis carinii pneumonia: correspondence, 91

Polyarthralgia, Microbiological investigation of polyarthralgia,777

Polymerase chain reactionAbsence of pepsinogen A3 gene expression in the gastricimucosa

of patients with gastric cancer, 376Chlamydia trachomatis and ectopic pregnancy: retrospective

analysis of salpingectomy specimens, endometrial biopsies,and cervical smears, 815

Comparative analysis of human papillomavirus detection byPCR and non-isotopic in situ hybridisation, 415

Detection of cytomegalovirus using PCR in serum from renaltransplant recipients, 575

Hepatitis C virus replication in hepatocellular carcinoma, 880High prevalence of Helicobacter pylori in saliva demonstrated by

a novel PCR assay, 662Human papillomavirus in false negative archival cervical smears:

implications for screening for cervical cancer, 728IS6 110 based amplityping assay and RFLP fingerprinting of

clinical isolates of Mycobacterium tuberculosis, 924Management of blood donors whose donations are repeatedly

falsely positive by the HIV antibody screening test, 865Molecular markers for diagnostic cytology of neoplasms in

the head region of the pancreas: mutation of K-ras andoverexpression of the p53 protein product, 218

Mulitplex PCR for identifying mycobacterial isolates, 203Quantitation ofhepatitis C viral RNA in liver and serum samples

using competitive polymerase chain reaction, 820Retrospective determination of HIV-1 status by a PCR methodon paraffin wax embedded sections, 733

Routine application of the polymerase chain reaction fordetection ofMycobacterium tuberculosis in clinical samples, 810

The polymerase chain reaction in the demonstration ofmonoclonality in T cell lymphomas, 1045

Value of screening for oro-pharyngeal Chlamydia trachomatisinfection, 658

Polyps, Expression of proliferating cell nuclear antigen inhyperplastic polyps, adenomas and inflammatory cloacogenicpolyps of the large intestine, 46

1163

Subject index

Post-mortem, Public perceptions of necropsy: leader, 497Post-transplant lymphoproliferative disease, Tissue

polypeptide specific antigen for the detection oflymphoproliferative diseases induced by cyclosporin, 1039

Pregnancy, Specificity and usefulness of an IgE immunosorbentagglutination assay for toxoplasmosis, 64

Prenatal diagnosis, Screening criteria for beta thalassaemia traitin pregnant women, 1054

Preterm prelabour amniorrhexis, Concentration of fetalplasma and amniotic fluid interleukin-I in pregnanciescomplicated by preterm prelabour amniorrhexis, 368

Primary polycythaemia, Activated phenotype in neutrophilsand monocytes from patients with primary proliferativepolycythaemia, 525

Primary sclerosing cholangitis, Sampling variability ofpercutaneous liver biopsy in primary sclerosing cholangitis, 933

Procollagen type 1, Enhanced expression of type I procollagenand transforming growth factor-beta in tuberculin induceddelayed type hypersensitivity, 339

Proctocolectomy, Effect of proctocolectomy on serumantineutrophil cytoplasmic antibodies in patients with chroniculcerative colitis, 645

Prognosis, Prognostic factors in primary breast carcinoma: leader,981

Proliferating cell nuclear antigen, Expression of proliferatingcell nuclear antigen in hyperplastic polyps, adenomas andinflammatory cloacogenic polyps of the large intestine, 46

ProliferationAtypical ductal hyperplasia of the breast: clonal proliferation

with loss of heterozygosity on chromosomes 16q andl 17p,611

Effect of interleukins on the proliferation and survival of B cellchronic lymphocytic leukaemia cells, 482

Immunohistochemical analysis ofT cell proliferation in normaltonsil and B cell lymphoma, 873

Longstanding proliferation of CD3 negative large granularlymphocytes preceding the development of high grade non-Hodgkin's lymphoma, 672

Quantification of proliferative activity in colorectal adenomasby mitotic counts: relationship to degree of dysplasia andhistological type, 620

Proliferative activity, Immunohistochemical quantitation ofoestrogen receptors and proliferative activity in oestrogenreceptor positive breast cancer, 42.9

ProstateCimentin and cytokeratin expression in nodular hyperplasia and

carcinoma of the prostate, 1031Macroscopic examination of prostatic specimens: leader, 693

Prosthetic cruciate ligament, Histological changes associatedwith an artificial anterior cruciate ligament, 556

Protein S, Acquired protein S deficiency in a patient with systemiclupus erythematosus causing central retinal vein thrombosis,387

Pseudoanosarcomtous a, Pseudoangiosarcomatouscarcinoma of the genitourinary tract, 1059

Pseudoclusters of infection, "Pseudoclusters" and typing byrandom amplification of polymorphic DNA of Aspergillusfumigatus, 183

Pseudoinclusions, Nuclear pseudoinclusions in melanocyticnaevi and melanomas, 676

Pseudomonas fluorescens, Rate of growth of Pseudomonasfluorescens in donated blood, 717

Pseudomonas pseudomaUei, Latex agglutination for rapiddetection ofPseudomonaspseudomallei antigen in urine ofpatientswith melioidosis, 174

Pulmonary emphysema, Macroscopic assessment ofpulmonaryemphysema by image analysis, 318

Pulmonary thromboembolism, Seasonal variation in thenecropsy incidence of pulmonary thromboembolism:correspondence, 883

Pyrexia ofunknown origin, Detection of mycobacteria in bonemarrow biopsy specimens taken to investigate pyrexia ofunknown origin, 706

QQBEND10, QBEND10 for the diagnosis of myelodysplasticsyndromes in routinely processed bone marrow biopsyspecimens, 291: correspondence, 884

Quality assessment, Internal quality assurance in a clinicalvirology laboratory. I. Internal quality assessment, 168

Quality assurance

Composition of cervical smears in patients with and without acervical ectropion, 408

Intemal audit in a microbiology laboratory, 560Internal quality assurance in a clinical virology laboratory. I.

Internal quality assessment, 168Internal quality assurance in a clinical virology laboratory. II.

Internal quality control, 198Quality control, Role ofre-screening of cervical smears in internal

quality control, 1002Quaity microbiology service, Perceptions of a medical

microbiology service: a survey of Iaboratory users, 915Quant, A proposed SI unit for number: corespondence, 187Quantification, Simple method for quantifying viable bacterialnumbers in sputum, 719

Quickscore, A "quickscore" method for immunohistochemicalsemiquantitation: validation for oestrogen receptor in breastcarcinomas, 876

RRAPD typing, "Pseudoclusters" and typing by random

amplification of polymorphic DNA of Aspergilusf;nigatus, 183Rb, p53, Rb and bcl-2 expression during the cell cycle: a study

in phytohaemagglutinin stimulated lymphocytes and microwaveirradiated lymphoid tissue sections, 151

Re-screening, Role of re-screening of cervical smears in internalquality control, 1002

Rectal cancer, Influence oflocal peritoneal involvement on pelvicrecurrence and prognosis in rectal cancer, 849

Red cell pits, Functional hyposplenism foHlowing allogeneic bonemarrow transplantation, 257

Reed-Sternberg cellsDown-regulation of Epstein-Barr virus nuclear antigen I in

Reed-Stemnberg cells of Hodgkin's disease, 845Transforming growth factor betal messenger RNA in

Reed-Stemnberg cells in nodular sclerosing Hodgkin's disease,160

Regional oncology centre, Audit of tumour pathology reviewedby a regional oncology centre: correspondence, 690

Renal cell carcinoma, Parathyroid hormone related proteinand interleukin-6 mRNA expression in larynx and renal cellcarcinomas from normocalcaemic and hypercalcaemic patients,896

Renal failureAcute hepatic and renal failure caused by Pneumocystis carinni

in patients with AIDS, 975Renal failure in a patient with chronic lymphocytic leukaemia

treated with fludarabine, 181Renal peripehis, Angiomyxoid tumour in the renal peripelvic

tissues with features of aggressive angiomyxoma, 82Renal transplant, Detection of cytomegalovirus using PCR inserum from renal transplant recipients, 575

Renal transplant screening, Routine urinalysis in renaltransplant patients, 383

Replication, Hepatitis C virus replication in hepatocellularcarcnoma, 880

Research, Have declining clinical necropsy rates reduced thecontribution of necropsy to medical research?, 402

Respirtory disease, Circulating endothelin-l concentrations inpatients with chronic hypoxia, 519

Retropubic prostatectomy, Macroscopic examination ofprostatic specimens: leader, 693

RFLP analysis, IS6110 based amplityping assay and RFLPfingerprinting of clinical isolates of Mycobacterium tuberculosis,924

Rhabdomyosarcoma, Desmin expression in rhabdomyo-sarcoma: influence of the desmin clone andimmunohistochemical method, 535

Risk factors, Immunological factors and risk of infection inplateau phase myeloma, 260

SSaccular aneurysms, Subarachnoid haemorrhage and mythsabout saccular aneurysms: leader, 1078

Saliva, High prevalence of Heicobacter pylon in salivademonstrated by a novel PCR assay, 662

Salivary gland, Lymphoepithelial carcinoma ofthe salivary gland:in situ detection of Epstein-Barr virus, 1022

Sampling variabity, Sampling variability of percutaneous liverbiopsy in primary sclerosing cholangitis, 933

Saudi Arabia, Variation in serum electrolytes and enzymeconcentrations in patients with sickle cell disease, 648

1164

Subject index

Schizophrenia, Volatile organic compounds in the breath ofpatients with schizophrenia, 466

ScreeningHuman papillomavirus in false negative archival cervical smears:

implications for screening for cervical cancer, 728Multifactorial audit of invasive cervical cancer: key lessons for

the National Screening Programme, 405: comspondence, 785Role ofre-screening ofcervical smears in internal quality control,

1002SDS-PAGE, Rapid and safe determination of human

apolipoprotein E genotypes by miniaturised SDS-PAGE in non-insulin dependent diabetes mellitus, 295

Seasonal variationSeasonal variation in the necropsy incidence of pulmonarythromboembolism: correspondence, 883

Seasonal variation in the necropsy incidence of pulmonarythromboembolism in Hong Kong, 578

Semiautomated analysis, Evaluation of the API-Campy Systemin the biochemical identification of hippurate negativecampylobacter strains isolated from faeces, 683

Septicaemia, Corynebacterium aquaticum septicaemia in aneutropenic patient, 971

Serodiagnosis, Immunoblotting in the diagnosis of culturenegative endocarditis caused by streptococci and enterococci,1130

Serological markers, Serological markers to differentiatebetween ulcerative colitis and Crohn's disease, 346

Serological testing, Serological testing in a microbiologylaboratory of specimens from patients with suspected infectiousdisease, 358

Serosa, Serosal reaction in chronic gastric ulcers: animmunohistochemical and ultrastructural study, 226

SI unit, A proposed SI unit for number: correspondence, 187Siclde cell disease, Variation in serum electrolytes and enzyme

concentrations in patients with sickle cell disease, 648Sigmoid colon, Immunohistochemical changes in sigmoid colon

after allogeneic and autologous bone marrow transplantation,308

Signet-ring cell lymphoma, B cell signet-ring cell lymphomaof bone marrow, 275

Simultaneous detection, Duplex PCR system for simultaneousdetection of Neisseria gonorrhoeae and Chlamydia trachomatis inclinical specimens, 101

Sinonasal lymphomas, Association of Epstein-Barr virus withsinonasal angiocentric T cell lymphoma, 946

Skin puncture blood, Lymphocyte subset counts in sldn punctureand venous blood compared, 1137

Slice radiography, Specimen slice radiography ofcancer in breastconserving excisions, 1028

Small intestinal permeability, Lymphocytic gastritis andassociated small bowel disease: a diffuse lymphocyticgastroenteropathy?, 939

Smoking, Free radical activity in young adult cigarette smokers,385

Smooth muscle actin, S100, alpha-smooth muscle actin andcytokeratin 19 immunohistochemistry in odontogenic and softtissue myxomas, 759

Specimen resection margins, A rapid and safe method to fixIndia ink on specimen resection margins: correspondence, 689

Splenic lymphoma, Splenic lymphoma with circulating villouslymphocytes, 584

Sputum, Simple method for quantifing viable bacterial numbersin sputum, 719

Squamous cell carcinomaDetection of integrated human papillomavirus 16 DNA insquamous cell carcinoma of the cervix: correspondence, 393

HPV type 16 in conjunctival and junctional papilloma, dysplasia,and squamous cell carcinoma, 1106

p53 protein accumulation in oesophageal squamous cellcarcinomas and precancerous lesions, 531

Parathyroid hormone related protein and interleukin-6 mRNAexpression in larynx and renal cell carcinomas fromnormocalcaemic and hypercalcaemic patients, 896

Parathyroid hormone related protein in oral squamous cellcarcinomas invading the mandible, 300

Staphylococci, Lethal synergy between toxins of staphylococciand enterobacteria: implications for sudden infant deathsyndrome, 929

Steroid hormone receptors, Steroid hormone receptors andtheir clinical significance in cancer: leader, 890

Streptococcus pneumoniae, Detection of C-polysaccharide inserum of patients with Streptococcus pneumoniae bacteraemia,803

Stromal sarcoma, Uterine stromal sarcoma following tamoxifentreatment: correspondence, 596

Subarachnoid haemorrhage, Subarachnoid haemorrhage andmyths about saccular aneurysms: leader, 1078

Sudden death, Sudden death from coronary artery dissection,781

Sudden infant death syndromeLethal synergy between toxins of staphylococci and

enterobacteria: implications for sudden infant deathsyndrome, 929

Postmortem blood ferritin concentrations in sudden infant deathsyndrome, 763

Superheating, Should superheating be used for immuno-histochemistry?: correspondence, 883

Survey, Perceptions of a medical microbiology service: a surveyof laboratory users, 915

Synergy, Lethal synergy between toxins of staphylococci andenterobacteria: implications for sudden infant death syndrome,929

Synthetic HIV antigens, False negative results in enzyme linkedimmunosorbent assays using synthetic HIV antigens, 490

Systemic lupus erythematosus, Acquired protein S deficiencyin a patient with systemic lupus erythematosus causing centralretinal vein thrombosis, 387

TT cell, Immunohistochemical analysis of T cell proliferation innormal tonsil and B cell lymphoma, 873

T cell lymphoma, The polymerase chain reaction in thedemonstration of monoclonality in T cell lymphomas, 1045

T cell receptor beta and gamma, The polymerase chain reactionin the demonstration of monoclonality in T cell lymphomas,1045

Tachyzoite antigen, Serological reactivity against cyst andtachyzoite antigens of Toxoplasma gondii determined by FAST-ELISA, 908

Tamoxifen, Uterine stromal sarcoma following tamoxifentreatment: correspondence, 596

Targeting, Distribution of OV-TL 3 and MOv18 in normal andmalignant ovarian tissue, 631

Technicon H.2 counter, Screening criteria for beta thalassaemiatrait in pregnant women, 1054

Test demand, Managing test demand by clinicians: computerassisted guidelines: leader, 98

Testicular vasculitis, Isolated testicular vasculitis mimicking atesticular neoplasm: correspondence, 496

Testing regimes, Testing healthcare staff for infection with HIVand hepatitis: logistic and ethical considerations: leader, 885

ThalassaemiaComparison ofhaemoglobin H inclusion bodies with embryonic

F, globin in screening for alpha thalassaemia, 861Frequency of coincident iron deficiency and beta-thalassaemia

trait in British Asian children, 594Thalassaemia trait, Screening criteria for beta thalassaemia trait

in pregnant women, 1054Thiol methyltransferase, Thiol methyltransferase activity in

colonocytes and erythrocyte membranes, 641Thromboembolism, Seasonal variation in the necropsy incidence

of pulmonary thromboembolism in Hong Kong, 578Thromboplastin, Effect of thromboplastin and coagulometer

interaction on the precision of the International NormalisedRatio, 13

Thrombotic occlusions, Recurrent thrombotic occlusions ofarteries and veins caused by intravascular metastaticadenocarcinoma: correspondence, 186

Thymidine kinase, Plasma cell proliferation in monoclonalgammopathies: measurement using BU-1 antibody in flowcytometry and microscopy: comparison with serum thymidinekinase, 477

Thymoma, Oncogene proteins and proliferation antigens inthymomas: increased expression of epidermal growth factorreceptor and Ki67 antigen, 447

Thyroid histology, Histological features of the thyroid gland ina patient with lithium induced thyrotoxicosis, 582

Thyroid lymphomas, Immunohistochemical detection of p53and Bcl-2 proteins in Hashimoto's thyroiditis and primarythyroid lymphomas, 239

1165

Subject index

Thyroid stimulating hormone, Thyroid autoantibodies and theresponse to thyrotropin releasing hormone in patients withsubclinical hypothyroidism, 463

Thyrotoxicosis, Histological features of the thyroid gland in apatient with lithium induced thyrotoxicosis, 582

Thyrotropin releasing hormone, Thyroid autoantibodies andthe response to thyrotropin releasing hormone in patients withsubclinical hypothyroidism, 463

Tissue polypeptide specific antigen, Tissue polypeptide specificantigen for the detection oflymphoproliferative diseases inducedby cyclosporin, 1039

Tissue processing, Distribution of cervical intraepithelialneoplasia: are hysterectomy specimens sampled appropriately?,323

Tn associated antigen, Immunocytological analysis of the Tnassociated antigen 83D4 in serous effusions from patients withcancer: comparison with Tn soluble glycoprotein, 433

Topoisomerase IH-alpha, Immunohistochemical study oftopoisomerase II-alpha expression in primary ductal carcinomaof the breast, 147

Toxins, Lethal synergy between toxins of staphylococci andenterobacteria: implications for sudden infant death syndrome,929

Toxoplasma antibodies, Enzyme immunoassays for IgG andIgM antibodies to Toxoplasma gondii based on enhancedchemiluminescence, 652

Toxoplasma gondii, Serological reactivity against cyst andtachyzoite antigens of Toxoplasma gondii determined by FAST-ELISA, 908

Toxoplasma specific IgA, The value ofToxoplasma specific IgAin diagnosis: correspondence, 689

Toxoplasmosis, Specificity and usefulness of an IgEimmunosorbent agglutination assay for toxoplasmosis, 64

Transferrin, Changes in transferrin saturation after treatmentwith the oral iron chelator deferiprone in patients with ironoverload, 110

Transforming growth factor-beta, Enhanced expression oftype1 procollagen and transforming growth factor-beta in tuberculininduced delayed type hypersensitivity, 339

Transforming growth factor betalRole oftransforming growth factor betal on hepatic regenerationand apoptosis in liver diseases, 1093

Transforming growth factor beta 1 messenger RNA inReed-Stemnberg cells in nodular sclerosing Hodgkin's disease,160

Transient abnormal myelopoiesis, Transient abnormalmyelopoiesis accompanied by hepatic fibrosis in two infantswith Down syndrome, 973

Transplantation, Detection of cytomegalovirus using PCR inserum from renal transplant recipients, 575

Transport medium, Effect of transport medium andtransportation time on culture of Helicobacter pylori from gastricbiopsy specimens: correspondence, 91

Transurethral prostatectomy, Macroscopic examination ofprostatic specimens: leader, 693

Tuberculin, Enhanced expression of type 1 procollagen andtransforming growth factor-beta in tuberculin induced delayedtype hypersensitivity, 339

Tuberculosis, Lesser known mycobacteria: leader, 701Tumour histopathology, Audit of tumour histopathology

reviewed by a regional oncology centre, 245Tumour necrosis factor, Increased gastric production of

interleukin-8 and tumour necrosis factor in patients withHelicobacter pylori infection, 133

Tumour pathology, Audit of tumour pathology reviewed by aregional oncology centre: correspondence, 690

UUlcerative colitis

Effect of proctocolectomy on serum antineutrophil cytoplasmicantibodies in patients with chronic ulcerative colitis, 645

Histological discrimination of idiopathic inflammatory boweldisease from other types of colitis, 749

Intraepithelial and lamina propria leucocyte subsets ininflammatory bowel disease: an immunohistochemical studyof colon and rectal biopsy specimens, 743

Serological markers to differentiate between ulcerative colitisand Crohn's disease, 346

Urea hydrolysis, Intragastric urea hydrolysis in children infectedwith Helicobacter pylon: correspondence, 187

Urinalysis, Routine urinalysis in renal transplant patients, 383Urinary tract infection, Evaluation of the Cult-Dip Plus dip

slide method for urinary tract infection, 710Urogenital system, Necrobiotic granulomas of the urogenital

system: correspondence, 690Urothelial cancer, The clinical value of urinary cytology: 12

years of experience with 615 patients, 314Uterine stromal sarcoma, Uterine stromal sarcoma following

tamoxifen treatment: correspondence, 596Uteroplacental ischaemia, Observer reliability in assessing

placental maturity by histology, 420Uvitex 2B, Tissue diagnosis of intestinal microsporidiosis using

a fluorescent stain with Uvitex 2B, 1009

VVagina, Brenner tumour of the vagina, 678Vancomycin, Systemic absorption of vancomycin: correspondence,689

Vancomycin resistance, Neomycin blood agar as a selectivemedium for vancomycin resistant Enterococcus faecium, 1068

Variation, Pathologist variation in reporting cervical borderlineepithelial abnormalities and cervical intraepithelial neoplasia,59

Vascular anomaly, An unusual case of colonic angiodysplasia,272

VasculitisFormalin fixation and patterns of antineutrophil cytoplasmic

antibodies, 89Isolated testicular vasculitis mimicking a testicular neoplasm:

correspondence, 496Vasodilators, Orthostatic hypotension and vasodilatory peptides

in bronchial carcinoma, 1102Vertebral artery, A necropsy and histomorphometric study of

abnormalities in the course of the vertebral artery associatedwith ossified stylohyoid ligaments, 637

Villitis of unknown aetiology, Expression of MHC class IIantigens by placental villi: no relationship with villitis ofunknown origin, 494

Villous lymphocytes, Splenic lymphoma with circulating villouslymphocytes, 584

Vimentin, Cimentin and cytokeratin expression in nodularhyperplasia and carcinoma of the prostate, 1031

Virology, Internal quality assurance in a clinical virologylaboratory. II. Internal quality control, 198

Visceral giant celi arteritis, Idiopathic granulomatous vasculitis:response to immunosuppressive therapy, 579

Volatile organic compounds, Origins of breath isoprene:correspondence, 979

Vulva, Pseudoangiosarcomatous carcinoma of the genitourinarytract, 1059

wWaldenstrom's macroglobulinaemia

Hypercalcaemia due to calcium binding IgM paraprotein inWaldenstrom's macroglobulinaemia, 961

Inaccurate haemoglobin estimation in Waldenstr6m'smacroglobulinaemia: correspondence, 787

Waldeyer's ring lymphomas, Association of Epstein-Barr viruswith sinonasal angiocentric T cell lymphoma, 946

Waterhouse-Friderichsen syndrome, Waterhouse-Friderichsen syndrome complicating primary biliary sepsis dueto Pasteurella multocida in a patient with cirrhosis, 775

Western blotting, Chromogranin positive cells in colorectalcarcinoma and transitional mucosa, 754

Wound healing, Epidermal differentiation and dermal changesin healing following treatment of surgical wounds with sheetsof cultured allogeneic keratinocytes, 1087

x, chains, Comparison of haemoglobin H inclusion bodies withembryonic globin in screening for alpha thalassaemia, 861

yYeasts, Evaluation of the AUXACOLOR system, a new method

of clinical yeast identification, 807Young adults, Free radical activity in young adult cigarette

smokers, 385

1166

The Journal of the Association of Clinical Patbologists

VOLUME 48 * 1995

Editor: David LoevvAssistant Editor: Heleni HolzelYClchalZ1 Editor: Andrea HorganEditorial Assistant: -Mavis Burrell

EDITORIAL BOARDA L AppletonC C BirdA WV BovlstonD BurnettJ Crocker

J D) DaviesF V FlvnnD J GoldieJ H E HayekF D Lee

J S LllcymanA J MalcolmJ H -McCarthyR N PeelM4 D Penney

R S PereiraGL Ridg-wavC RobertsD N SlaterR C Spencer

D Tarin1) R TurnerD A NWinfieldB WVoodcockEditor. JiA.U

PuNbishingG lJlp