A One-Volume Library

of Essential

AIDS Research

AIDS: Papers from Science, 1982-1985Edited by Ruth Kulstad

Some of the most frequently cited papers onacquired immune deficiency syndrome (AIDS)that appeared in Science between August 1982and September 1985 are included in thisvolume. Arranged chronologically, these 108research papers and Science news reports showhow far AIDS research has come and provide anindication of the directions in which it might go.This fully indexed collection is useful not onlyfor the experimental data and conclusions, butalso as an excellent source of references toAIDS work in other major journals worldwide.

An overview of research in AIDS to date isprovided in the introduction by Dr. MyronEssex, chairman of the Department of CancerBiology, Harvard University School of PublicHealth.

654 pp.; fully indexed and illustratedHardcover $32.95 (AAAS member price $26.35)Softcover $19.95 (AAAS member price $15.95)

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bItermediary Mbtabollsm. Otto Hoffinann-Osten-hof, Ed. Van Nostrand Reinhold, New York, 1987. xviii,492 pp., illus. $79.95.The lntmatonal Atomic Energy Agency and

World Nucler Order. Lawrence Scheinman. Resourcesfor the Future, Washington, DC, 1987. xviii, 320 pp.Paper, $16.95.

nfintendonal Handbook of Psychology. Albert R.Gilgen and Carol K. Gilgen, Eds. Groenwood, Westport,Cr, 1987. xviii, 629 pp. $75.

Inroduction to Common Usp. Taiichi Yuasa andMasami Hagiya. Academic Press, Orlando, FL, 1987. x,293 pp. $29.95. Translated from the Japanese edition(Tokyo, 1986) by Richard Wyhrauch and Yasuko Kita-jima.

Introductlon to Dynamis of Continuous Media.Julian L. Davis. Macmillan, New York, 1987. x, 390 pp.,ilus. $34.95.intoduction to the Physics and Techniques of

Remote Sening. Charls Elachi. Wiley-Interscience,New York, 1987. xviii, 413 pp., illus. $44.95. WileySerics in Rcmote Scnsing.

intoduction to Thermomechanics of MagneticFluids. V. G. Bashtovoy, B. M. Berkovsky, and A. N.Vislovich. Englishedition editor, R. E. Rosensweig.Hemisphere (Harper and Row), New York, 1987. xii,216 pp., illus. $84.50. Translated from the Russianedition.Unewr Models for Unbalanced Data. Shayle R.

Searke. Wily, Ncw York, 1987. mxiv, 536 pp. illus.$49.95. Wley Scrics in Probability and MadmticalStatistics.The Lost Notbos of Loren Elley. Kenneth

Heuer, Ed. Little, Brown, Boston, 1987. xiv, 260 pp.,ilus., + plates. $24.95.Marine Rource Mapping. An Introductory Man-

ual. M. J. A. Buter et al. Food and Agriculture O za-tion of the United Nations, Rome, 1986 (U.S. distribu-tor, Benan/Unipub, Lanham, MD). xxii, 256 pp, illus.,+ charts in poce Paper, $16.75. FAO Fisheries Tech-nical Papr24

r of Be Stars. Arne Slettebak and ThcodoreP. Snow, Eds. Cambridge University Press, New York,1987. xviii, 557 pp., ilMls. $79.50. Prom a colloquium,Bouler, CO, Aug. 1986.Physics of the Stoic. S. Sambursky. Princeton

University Press, Princeton, NJ, 1987. xii, 153 pp.Paper, $8.95. Reprint, 1959 edition.Physlologiaf Response of Maine Organisms

to Envlronmentai Strsse. Janet V. Dorigan andFlorence L. Hanison. U.S. Department of EncrmgEcological Rcsearch Division, Washington, DC, 1997.x, 501 pp., ilus. Paper, $15.

Poiltcs Verus the Law. The Reinterpretation ofthe ABM Treaty. Raymond L. Garthoff? BrookingsInstitution, Washington, DC, 1987. x, 117 pp. Paper,$8.95.Polymer. An Encyclopedic SourcebookofEngneer-

ing Properties. Wiley-Intcrscicnce, New York, 1987.xxvi, 665 pp., illus. $64.95. Encyclopedia Reprint Series.Polymer for High Technology. Electronics and

Photonics. Murrae J. Bowden and S. Richard Turner,Eds. American Chankal Society, Washinton, DC,1987. x, 628 pp., ilus. $109.95. ACS Symposium Series,voL 346. Based on a symposium, Anaheim, CA, Sept.1986.Principbs of Rock Fragmentation. George B.

Clark. Wilcy-Interscience, New York, 1987. xii, 61-0 pp.,illus. $65.The Production of New Potato Varie. Techno-

logical Advances. G. J. Jellis and D. E. Richardons, Eds.Cambridge University Press, New York, 1987. xx, 358p. iLhs. $49.50. Based on a meeting, Cambridge,Egland, Dec. 1985.Proteases In Biological Control and Biotechnolo-

gy. Dennis D. Cunningham and George L. Log, Eds.Liss, New York, 1987. x, 326 pp. illus. $100. UCLASymposia on Molecular and ceflr Biology, vol. 57.Based on a symposium, Park City, UT, Pcb. 1986.Tiger of the World. The Biology, Biopolitics, Man-

agement, and Conservation of an Endangered Species.Ronald L. Tilson and Ulysses S. Seal, Eds. Noycs, ParkRidge, NJ, 1987. xxx, 510 pp., illus. $64. Noyes Scriesin Animal Behavior, Ecology, Conservation and Man-ament. From a symposium, Minneapolis, MN, April

Time Travel and Other Mathematical Bewlker-mwnte. Martin Gardner. Freeman, New York, 1987. xiv,295 pp., illus. $17.95; paper, $12.95.Triasi-Juraic Rlft-Basn Sedimentolgy. His-

tory and Methods. John C. Lorenz. Van NostrandReinhold, New York, 1987. xviii, 315 pp., illus. $42.95.

25 MARCH I988

POSITIONS WANTED

Biochemitry Technolit,B.S., Reearch Associate,1981. Scventen years ofxpernce (research, industry)in a variety of biochmical, enzymatc, ELISA immuno-logical assays, which involved g radioisotopic tech-

niques, paper chromatography, measure enzme activi-tieS, vanous colrimetric techiques for locating, quanti-tatin protens and carbohydrates. Purification and char-actenzaton of protein, nzymes. Experiencd with gel

filtration, ion-chang, affinity cmatoaphy, l

elphois and isoectric Also recombi-

nant membrane, membrane prearation, bacteria culure.Exceclnlt skills. Seis rsearch/adc/duti ormedical labo ry speaking English in Canada. Box 38,SCIENCE.

Physiologist, M.D. Researc excperience in nephrophys-iolog (hemodynamics, endocrinology). Clinical experi-encem general intemnal medicine. Teaching experience in

medical physiology. Box 31, SC:IENCE.

POSITIONS WANTED

Biohemist (PhD., 1975). Major contibution to druginteracton, metabolism, and toxiaty. Worked with hu-man tissues, tumors, animals, plants, bacteria, and cul-tured cells. Thirty-fourpublications in rcfreed journals.Broad expriewe in vanous techniques: HPLC with UVand elto:chemical reductive/oxidative detectors, oxy-polarography, spectrophotomey, ulracentrifuion,scintillation counting, DNA and protein synthesis, andisolation of sbce ar orgzanelles. Eensive Macintosheience. U.S. citizen. Trilingal. Seking challenginiesearch or management position in rustncs. Box 4f,SCIENCE.

POSITIONS OPEN

ADJUNCT ASSISTANT PROFESSOROF SUR-GERY/ONCOLOGY. Nontenure-track grant-support-ed position availabk for a cellular immunol with atleast 3 years of postdoctoral experince with biolgicalresponse modifiers and human tumor immunology. Senrdsuma and names of thre frnces by 15 Apr 1988to: Dr. Sidny Golub, Sury/Oncolo , 54-140CHS, UCIA School of Angdes CA90024. UCLA anAffirmatiA on/Equ oEmpoyer.

ANATOMY/CELL BIOLOGY FACULTY. Threetenure-track positions at any rank for individuals withability to maintain indepndent, creative msearch pro

gram in a depant with strong emphasis on rescarchand scholary atty. P nce given to applicantsworking on basic aspects of celluar biology and/ormolecular ncience; such as membrane s#al trans-duction, growth regulation, receptors, protem traffick-ing, and ncural injury and repair. Ability to teach eitherhistolgy, neuro-, or gross anatomy to medical/graduatestudents required. The Chicago Medical School is locat-ed 38 miles north of downtown Chicago in new, well-equpped facilities. Submit curriclum vitae and thrde

rEfi rcnces to: Dr. RL G. Kemp, Biological Chemistryand Structwe, University of Ha Sciences;Tneiago Medical School, 3333 Green Bay Road,

North Chicago, IL 60064.

ANATOMY/CELL BIOLOGY

Tenure-track position as ASSISTANT PROFES-SOR in human biology beginning 25 Auust 1988.

Ph.D. required. Prmary responsibihties will be

introductory anatomy and physiology, cell biology andcomparative anatomy, wit contributions to biology andgrad7uate programs as needed.

Opportunities are available for interdisdiplinary teach-expected. Send curriculum vitae,

transcripts (undergraduate/graduate), and three lettcrs ofrefernce by 28 April 1988 to: Dr. T. Sager, HumanBiolog, ES 301, University of Wisconsin-GreenBa, rn Bay, WI 54311-7001. Equal OpporuitylAfrvAction Emplyfr.

DEPARTMENT OF BIOLOGYUNIVERSITY OF NEVADA, RENO

ANIMAL ECOLOGIST ANDANIMAL PHYSIOLOGIST

Applications are inited for two 1-year temoporarypositions, lecturer or assist professor, for animal ecol-ogt and animal physiolo, iwhich aregotedto be

finded begimning fill 1998. Animal ecologist: Tcach-ing: Animal Biology, General Ecology, CommunityEcology. Research: Behavior, populaon or communityecology. Animal physioli: Teaching: human anato-my and physiology, comparative physiology, and a grad-

uate seminar. Research: adaptations ofvertebrates and/or

invertebrates to desert or montane environments desir-

able. Both positions require an earned Ph.D. (all-but-dissertation considered); teaching and postdctoral expe-rience desirabk. Applications: letter of nmtent, curriculumvitae with statement of research and teaching interests,transcript, and names and addresse offive references to:Chairperson, D)epartnant of BiOlOgy, Univmerity Of

Necd, Ren,-INV 89557-0015. lDcadline:1 >i1988 or until positions are filled.AffirmatieAction/Eqa Expluyr. Uxi

sity ofNeada, Reno, only S.cis and alen

awfidly atoized to wo* States.

PERSONNEL PLACEMENT I553

PersonnelPlacement

SCIENCE publishes each Friday, except the last Fridayof the year. Advertising is accepted only in writing; noabbreviations. Any deadline in ad must be at least 2weeks after date of issue in which ad appears. Also,personnel advertising is accepted only with the under-standing that the advertiser does not discriminateamong applicants on the basis of race, sex, religion,age, color, national origin, handicap, or sexual prefer-ence. SCIENCE reserves the right, in its discretion, todecline to publish advertisements submitted to it.

UNE C IFIED NADVERTSNG DEADUIES:Thursday, 10 a.m., 2 weeks prior to issue date (mailedon issue date). For deadlines for display advertising,please contact Scherago Associates.

POSITIONS WANTED: 40t per word, plus $4 for use ofbox number, per week. $10 minimum, per week.Prepayment required. This rate is available only toindividuals seeking jobs.

UNE CLED (PO OPEt COURSES,FELLOWS , MARKEPLCEn so forh):$38.00 per line; $380 minimum, per week (minimumcharge covers one inch on a singl column; one inchequas 10 lines of 52 characters and spaces per line).No charge for use of box number. No agency commis-sion for ads less than 4 inches. No cash discount.Prepayment required for all foreign ads. Purchaseorders and/or cover letter including billing addressrequired for all other advertising.

To ESTMATE ad coat:Structure ad copy on a separate page, on lines of 52characters and spaces. Include any desired heading.Each line of head, and/or extra line spaces, and allpartial lines (including centered reply information) arecounted as full lines. Ad titles located within the textare printed in boldface caps and are only 32 charac-ters per line. In ESTIMATING the cost, multiply totallines x $38.00 = approximate cost of ad. (This is anapproximate cost ONLY: Allow for variation betweenestimated lines and actual typeset lines and the resuft-ing final cost. Purchase orders must allow for somedegree of flexibility and/or adjustment.)

CANCELLATION POLICY:NOTE: Ad cancellations made after Thursday, TWOweeks prior to issue date incur a 10% productioncharge. Fnal deadline for cancellations is 12 p.m.Tuesday, ONE week prior to issue date. Cancellationsmust be in writing.

Send cOPy for all Poeltons Warnd ads and UneClassified ads less than 1/6 page in size (39 lines) to:

SCIENCE Casilfid A ti1333 H Stree, NW, Room 90

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Telephone: 212-730-1050Blind ad replies should be addressed as follows:

Box r M e)SCIENCE

1333 H Stret, NWWasngtbn, DC 20005

POSITIONS OPEN

AQUACULTURE SYSTEMS SCIENTIST-Ten-ure-track position at associate professor/professor level inSchool of Natural Resources beginning 1 July 1988.Direct graduate research in aquaculture and provideeatension leadership to developing industry. Send curric-ulum vitae, statment of research imteres, and names offour individuals from whom letters of reference ma besolicited. Consideration of applications begins 1 April1988. Apply: Dr. Charles F. Ce,Aq re S hComm*ier, 210 Kottman Hall, The Ohio State Uni-verity, 2021 Coffly Road, Cohlmbu, OH 43210-1085. The Obio State Unernty is an Equal OpprtunitylAjfintiveAcaiom Explyfr.

ASSISTANT HORTICULTURISTAcademic carecr-track, 11-month assistant horticultur-

ist in mitegrated citrus managnt so develop moreefficient cultu practices for atrus production, especal-ly in the areas ofnutrition and irrigation. The position isa 75% Agricukural Expeiment Stationre appoint-ment with a 25% appointment in Cooperative Extensionwithin the Department of Botany and Plnt Sciences atthe University of California, Riverside. Responsibiliticsinclude development of a research program to adapt andtest the efficacy ofmajor advances in basic research to theproduction of citrus. Field research will be conducted atappropriate off-campus locations, incuding the San Joa-suin tallq. Extnsion responsibilitics include conduct-mg tranug scssions and short courses to disseminatercearch rcsults to the industry, and to ficilitatc theirimplementation by growers. Thc position is intended tocombine aspects or both applied and basic research.Requires a Ph.D. degre specializing in plant physiobgy,botany, hortcu or oter plant scicnce, with demon-sred experience in designing, conducting, analying,and int g field research, especial the physiologyof plant nutrition or irrigation of tree crops. Send kterof application, curriculum vitae, statement of researchint , transcipts (recent graduates), and at least threeconfidential letters ofevaluation so: Dr. Carol J. Lovatt,Chair, Search Commitee, Attentio: Susan Miller,Deprt fBotanyand Plant Sdences, Un iof Califoia, Riveside, CA 92521. The position willremain open until filled with referencC given candidatesapplying ore 15 Ma 1988. The Unnieniyffr-ma, Rimside, is an AJAiolEqual OppotmutyEmpleyr. AMiofties and women ar eneouraged to p.

ASSISTANT PROFESSOR, Department of Anato-my, to teach neuroanatomy, and participate in the teach-ing of gross anatomy. The successful candidate will bexpected to develop aresarch program which is compet-

itive for funding, m the functional anatomy and biomc-chanics of the lower limb, in the cellular biology ofneurological and vascular changes of diabetes, or inanother fild germane tO podiatc medicinc. The posi-tion will be available 1 July 1988. Scnd application,curriculum vitae, and the names and addresses of three

efernces to: Dr. Bruce Elliot Hirsch, Department of

A n, Pnqt Colc of Podiatric Medi-

cine, 8ehat RaccStroet,PA 19107.Equa Opprtuniy Empoyer.

ASSISTANT PROFESSOR OF MICROBIOLO-GY. This tenure-trac positon is available immediately.Candidates should have a Ph.D., M.D., D.D.S., or anequivalent degree and at least 2 years of postdoctoraltraining. Prefrence will be given to applicants withresearch interests in immunology, especaily molecularaspects of the immune response, or in genetics of micro-bial pathogenicity. A broad backound in medical mi-croblogy is desirablc. The appointee is expected toconduct vigorous independent research and to teachmicrobiolgy to students of medicine, dentistry, andother health-related professions. Laboratory space andstar-up support will be provided. Salary is negotiable.Intereted persons should send curricula vitae, briefdesciptions of research interests, and the names and

of three refcrees from whom the applicant hasslicited of recommendation. All materials should

bc sent to: Dr. Thomas D. l Pron sor andCmFDmaxt of Aio~, School of

New York at Buffalo, 205 She nall Buffao,NY 14214. Target date for rcipt of applications is 1

June 1988. Ste Unisy ofNew rotk a anAffirintivAinEu O0pounity Empyr.

Is'4

Pulmonary Division, University of Pittsburgh Schoolof Medicine. Tenure/nontenure-track position at theASSISrANT PROFESSOR level available for Ph.D.with a strong background in cellular physiology andbiochemisty. The candidate would be exected to pur-sue an independent research program, as well as collabo-rate with M.D.'s interestod in the role of soluble media-tors of inmmon elaborated by neutrophils, macro-phages and lymphocytes in a variety ofparenchymallgdiseaes. Experience in tissue culture, ultructur andlipid and protein identification/purification is desired.Applicants should submit curriculum vitae, a statemcnt

£research interest, and three ktters of refcrence to:James Dauber, MD., Puhnonary Mediine, 440Scaife Hall, Pit PA 15261.An Eq O A a Actim E*ployer.

ASSISTANT PROFESSORDEPARTTMENT OF MEAT AND

ANIMAL SCIENCEUNIVERSITY OF WISCONSIN

Madison, Wiscosin 53706Large-animal growth biologist, capable of applying

the modem tehniques ofcelular and moleclar biology,biochmistry, endocrinology or genetics so the solutionof problems concerning growth of domestic animals.The candidate will have the responsibility to share in

teaducng undergraduate courses in beef production.ITere will bc an opportunity to develop graduate tach

areas ofthe candidate s interest. Position responsi-biities arc 60% rescarch and 40% tcaching.The candidate is expected to develop a substantial

research progam and to collaborate in research withother scientists on campus and to bring their expertse tobear on probkms offood producing animals.

It is expcted that the candidate will bc ofsuch caliberso qualifg for participation in one or more ofthe campusintrdicipinay nngprograms.

Caddtms aea Ph.D. dcgrec and preferablypostdoctoral training Position is available 1 Jfuly 1988,or as soon as possible after receipt of lettcr of appoint-ment.

Applications are due 1 June 1988, or until a satisfac-tory candidate is found. Applicauion, curriculum vitaeand three letters of reference should bc sent to:

Jack Rdedge, ChairmanMeat and An l Scence Department

1675 Observatory DriveUniversity ofWWuconsinMadis, WI 53706

The Uniersity Wisconsin ProidesEqual Opportnitisin Prgram and Epo.yme.

ASSISTANT PROFESSORPHARMACOLOGY-TENURE TRACK

The Fairlcigh S. Dickinson, Jr., Colleg of DentalMedicine seeks a full-timc, tenure-track assnt profes-sor in its Deparmnt ofPhamacology. Responsi ilitiesinclud: Teaching undauate and graduatc dentaland dental hygiene students; developing compettive

research pr a, and serving on committees.Requirements: Ph.D. in pharmacology, clinical degree

(D.M.D., D.D.S.) or 2 years of postdoctoral exprience.Submit curriculum vitae and three letters ot recom-

mendation by 25 April 1988 to: Univa Employ-ment Offic Falkih Diinson URiver Road, Teanc, NJ 07666.FDU is an Equal OppotunityAffinatfiv Action Em-

ployer. MIF

ASSISTANT PROFESSORS OFPHARMACEUTICS

STATE UNIVERSITY OF NEW YORKAT BUFFALO

Applications are invited for tenure-track positionsavailablc 1 Scptember 1988 for recently trained Ph.D.'sin drug metabolism, drug delivery, pha c s,

theoretical pharmacoinecics or analsis.Postdoc-

tral or previous experience estial. Applints shouldsubmit, by 30 June 1988, curriculm vitae, names ofthree references, and a sumary ofresearch interests to:Ho-Leung Fung, Ph.D, Department of Pharmaceu-

Sc lof m, Cooke HEall State Univcrsi-ty of£New Yorlc, Bufal, NY 14260. SUNT-AtBufflois anAffliwuatveAction/Equal Empoyr.

ASSISTANT PROFESSOR OFCELLULAR AND

MOLECULAR PHYSIOLOGYApplications are solicited for a position at the rank of

asistant professor in the tenure-track at the Dearmttof Celluar and Molecular Physiology, Yale UniversitySchool of Medicine, effctive 1 July 1988. Candidatesmust hold a M.D. or a Ph.D. dege with experience andinterest in membrane transport processes, more in partic-ular the cellhlar and molecular biology of membrane

-ns Opportuities are available for both collabora-tive and research and for graduate andmedical student teaching.Qual#dwmewoq,nwnhepbmar enur-ed to a . Complete curriculum vitae including publi-

cations an the names and addresses of three reerenMcsshould be sent prior so 15 April 1988 to:

Emile L. Boupaep, M.D.Chairm2n,Drtnt of Celular

and Molecular Physolg333 Cedar StreetP.O. Box 3333

New Haven, CT 06510rYa Unieniy is anAffirwuarwAtinEq" Opportu-

nty Employfr.

University of California, San Diego, School of Medi-cine is seeking outanding candidates to fill tenured-track pons at the ASSISTANT FOFULL PRO-FESSOR lvels. Demonstrated creativity and productiv-ity in the field of molecular biology as applied toNeurosciences are an essential criterafor appontment.The positions require teaching at the graduate andmedical school undergraduate levels. Oportunmties existfor collaborative research with the broad, mterdisciplin-ary Neuroscience Group at UCSD and associated institu-tions. Salary wiUl depend on qualifications of the appli-cants. All applications received by 31 May 1988 willreceive thorough consideration. Send curnculum vitae,bibliogaphy, and names and addresses offive referencesto: Dr. RLbt Ktan, De t of Neurosi-cnes,M-024, University ofCa San Diego, LaJolla, CA 92093. TheU sfC is an EqualOpotny/A firniatwActio Employev

SCIENCE, VOL. 239

ASSOCIATE DEANCOOPERATIVE EXTENSION

COLLEGE OF AGRICULTURAL ANDENVIRONMENTAL SCIENCES ANDDIVISION OF AGRICULTURE AND

NATURAL RESOURCESUNIVERS1TY OF CALIFORNIA, DAVISThe University ofCalifomia seeks an academic

kader to serve as associate dean, CooerativeEtension, College of Agricultural and Environ-mental Sciences and the Division ofAgricureand Natural Resources. This is a new position,75% full-time employment, in the Office of theDean, and a 25% full-time employment a int-ment as a cooperative extensiomst in affiliationwith one of the departments of the College andDivision. The position is available on or before 1July 1988 and iS an 11-month appointment for aperiod of 5 years, with the possibility of reap-pointtment. Primary responsibilities are: coordi-nation of Cooprative cnsion programs be-twecn the Davis Campus, counties and selectedrepions of the state; providing leadership, ad-ministrative support and coordination betweendepartment chairs, county directors, and state-wide program Associate Deans of CooperativeExtension at the Berkeley and Riverside Cam-puses in the development and maintenance ofCooperative Extension programs. A Ph.D. de-gree in a related field of agrcultural or environ-mcntal science is required.Dm s ed admin-istrative leadership Is desirable. Submit curricu-lum vitae, a statement ofadmintive interests,and names and addresses of three references to:Dean Charles E. Hess, Office of the Dean,College of itural and EnronmentalSciences, Unirsiy of Cif D , CA95616. Applications must be received by 1 May1988. The Uiersity ofCs4Jivwia is anAfia-tiveAconlEqual 0ppotuy Emplyer.

POSITIONS OPEN POSITIONS OPEN

RESEARCH ASSOCIATESMOLECULAR BIOLOGY

Amgen, an industry leader in advanced biotech-nology, develops products for a wide variety ofapplications. Recent progress has created oppor-tunities for Research Associates in our SpecialtyChemicals and Enzymes Group.

Qualified applicants should have a BS or MS inMolecular Biology, Biochemistry or a related disciplineand 2-4 years of experience in Prokaryotic MolecularBiology or Molecular Genetics. Experience with basicmolecular biological techniques such as libraryconstruction, vector construction, immunoblot analy-sis and enzyme assays is essential. Familiarity withGram positive organisms is highly desirable.Amgen offers a stimulating and challenging researchenvironment as well as an attractive location one hournorthwest of Los Angeles. Amgen also offers anexcellent compensation and benefits package.Qualified applicants should send a resume and a listof 3 references, in confidence, to:

Recruitment, Dept. #23AMGEN1900 Oak Terrace LaneThousand OaksCA 91320

Equal Opportunity Emplyer

MGtUNIVERSITY OF CALIFORNIA

Office of the PresidentDIRECTOR-NATURAL RESERVE SYSTEMAGRICULTURE AND NATURAL RESOURCES

The University of California's Natural Reserve System (NRS), was establishedin 1965 to protect for educational research purposes a series of undisturbed naturalareas representing the state's vast ecological diversity. Since then, the NRS hasgrown to include 27 reserves specially designated and managed for use as "outdoorclassrooms and laboratories" by students, teachers, and researchers from anyinstitution of higher education.The Director reports to the Vice President-Agriculture and Natural Resources,and administers and coordinates the development of the NRS in consultation withthe Universitywide NRS Faculty Advisory Committee. Responsibilities include:supervising the systemwide NRS staff; formulating and implementing systemwidestrategic, programmatic, and operational plans; developing budget requests; fa-cilitating and coordinating research and teaching programs on NRS reserves;

cultivating private donations; and interacting with natural resource oriented agenciesand organizations managing natural areas or otherwise sharing NRS objectives.REQUIREMENTS:A doctorate in a discipline associated with the biological or physical sciences,with a strong interdisciplinary perspective on research and teaching, and successfulexperience in the management and leadership of a large academic program, (orequivalent education and experience). Ability to motivate and supervise staff.Excellent oral, written, problem-solving, and decision-making skills. Strong in-terpersonal and conflict resolution skills. Knowledge of and commitment to theprinciples of equal opportunity and affirmative action in personnel and in programdelivery.SALARY RANGE:Starting salary commensurate with experience and qualifications ranging between$57,200 and $71,500. Excellent benefits including relocation package.APPLICATIONS:Please send resume, salary history, and letter of application, by April 15, 1988to:

University of CaliforniaOffice of the President-Search Committee 2

2199 Addison Street,Room 192 University HallBerkeley, California 94720

The growing S4.4 billion success ofAbbott Laboratories is due in part notonly to aggressive R&D but also to theexceptional management for which weAvewon considerable recognition. Thesestrengths extend to our PharmaceuticalProducts Division, where we now seekthe following scientists tojoin ourresearch teams.

Ph.D. PROTEINBIOCHEMIST

U

Within our Molecular and Cell BiologyDepartment, you'll be involved in thecloning and expression of proteins relatedto disease states in a wide variety ofdisciplines. Successful candidate willhave a Ph.D. with 2-5 years of post-doctoral experience in the purificationof proteins in the nanomolar andsubnanomolar range. Experience in thepurification of proteins from recombinantsources would be helpful, but notrequired.

Ph.D. BIOCHEMISTWithin our Immunoscience Division,you'll conduct research aimed towarddiscovering novel pharmaceuticals forthe treatment of inflammatory and allergicdiseases. This involves working with staffto develop new methods and in vitroassays in the area of lipid mediatorresearch. Ph.D. in biochemistry with 0-3years post doctoral experience required,along with a real interest inpharmaceutical development. Someexperience in lipid biochemistry orreceptor pharmacology is a plus.We offer a stimulating professional andscientific environment, as well as excellentsalaries and full benefits including profitsharing and stock retirement plans. Weare headquartered in an attractivesuburban area just 30 miles north ofChicago. For confidential consideration,please send your resume with salaryhistory to: Pat Handy, CorporatePlacement, Dept. SCI/3-25, AbbottLaboratories, Abbott Park, IL 60064.Abbott is an affirmative action employer.

QualityE Health CareV Worldwide

1888-1988

POSITIONS OPEN

ASSISTANT RESEARCH PHYSICISTUNIVERSITY OF CALIFORNI, IRVINEThe Departet of Physics, University of California,

Irvinc, anticipates an opening for an xperiened exp-mental research physicist (Ph.D. level) to work on aliquid argon detector development program anda heavywater Cirerkov detector proect. Emphasis is given tothe development and construction ofstatc-of-the-art lownoisc analog and digital electronics, and the computcr-based analysis of radioactive contamination and back-grounds for Cerenkcov detectors. Candidates must have abroad background in analog and digital electronics, andmust have extensiv aexpenence in high vacuum andcryogenic techniqucs applicable to liquid time projcctionchambers. Computing eperienc and solid knowledge inpartidc and nuclear physics is required Please sendrdsu, bibliography, and the names ofthrc profession-

IS to: Dr. Peter Doe, De t of Physis,UneyorstCalif rni Irvine, CA 92717. An Af-finxatim LioxlEqm Opportunity Emplyfe.

TEXAS-ASSOCIATE DEANFOR RESEARCH AND DIRECTORDENTAL SCIENCE INSTITUTE

Dental degree and Ph.D. or equivalent desirabk.Experience in denally related sponsored research andreserch administation highly desirable. Salary and posi-tion commensurate with bakground and xperience. TheUniveity Of Texs is an Eq Oppor Em .Women and mnorii ane u d to ply. Scndcurriculum vitae to: Dr. R L McDani, rman,Sear Commi for Assoiate Dean for Researchand Diector of DSI, University of Teas HeathScence Cnter Dental Branch, P.O. Box 20068,Houston, TX 77225.

ASSOCIATE DEAN FORRESEARCH/ASSOCIATE DIRECTOR

COLLEGE OF AGRICULTUREUNIVERSITY OF MISSOURI-COLUMBIAApplications are invited for the position of Associate

Dcan for Research, Colkge ofAgriculture and AssociateDirectr, Agricultural Experiment Station.The Associatc Dcan/Associate Director is responsibk

to the Dcan and Director for leadership in the adminis-trao, su ion, coordination and devebpment ofthe progams in Agrculure. These responsibil-ities inde working with ovcr 250 faculty members,department chairs in five colleges, 21 depatment, andeight outstate centes, campus and system-wide adinis-tratrs, agricultural and agribusiness clientele and nation-al leaders. Thc Associate Dcan represents theMissouri Agricultural Experiment Station m state, re-gional and national setngs relating to agricukural rc-

Candidates should have an carned doctoratc in anappropriate field of agricultural science, demonstratedsuccess in an adminitive role and a record of researchand cducational excellnce in thcir own disciplinc. Theindividual must be able to providc ladershp for thedeveopment ofa comprehensive and innovative researchprogram that seeks to enhance fundamental Owlcdas weil as to integrat the biological, physical, and socialsciencc disciplincs into mission-oriented, problem-solv-ing rcserhaedsSend nominations or applications by 29 April 1988 to:

Dr. Gary Alle, ChairSearch andS oe

College ofAgicutreUnivrityo MissuiCmia

2-69 ArclueBuildingColubia,MO 65211

The Uniei ofAfisoi is atAIffinmatieAction/Equal Opportunity Expver.

BIOLOGIST/ENVIRONMENTAL SCIENTST,assint/associate professor, tenure-track, fall 1988;PhD). required. To teach introductory courses in envi-ronmental studies, biology, and plant ocology. Broadtraning in plant ph , naural histry, or micobi-ology Is desied. Send curilum vit tans , andthedetr of reomedtoto: Mrs. Sua Man,Administrative Assistant, A-26, Johnson State Col-leg Johnson, VT 05656

The American Type Culture Collection is seeking anASSOCIATE DIRECTOR FOR SCIENCE, a keyleadership job for enhancment of the research potentialofATCC while keeping in balance the traditional smicerolc of the insttution.

Candidates should have a doctoral degrec in molecularbiology or related discipline, a proven record of grantsupport research, and experence in management ofdiverse scientific personnel.The ?osition will be responsible for guidance and

supervision of the de ts of bateriology, bioinfor-matics, cl cuil re, molecular and plasmiid biology,mycology and botany, protology, applied sciences, andvroloy

Salary commensurate with experience. Send r6sumrto: Personnel Administ, Departnment SC, 12301Parklawn Drive, Rockvile, MD 20852-1776.

STANFORD UNIVERSITYThe Depamnt of Biological Sciences is searching for

a BEHAVIORAL ECOLOGIST at the level of assist-ant professor. We seek an ecologit whose intcrcst focuson behavior. Thc succsful candidatc must have anottnigrecord of research. Teacha record of:h. T>ching rcsponsibilities

will inclde an undegraduate course in behavioral ecokl-r.Stajn Unie u an Equal Opportuit Emoer.WmKnaxd are c to

.Send c um vitae and te names of dtreerGIMMICC to: Behavioral Ecology Sear CommittD rtmnt of Bioogical Sdences, Sanford Univer-sdty, Sta , CA 94305-5020.

BIOLOGIST/ASSISTANT PROFESSORAn entry-level, tenure-trac position to begin August

1988. Ph.D. in biology isrquired. Teaching responsibil-ities will include parasitoogy and the coordination ofhboratories fora non-maors general biology course. Thedevelop t of an active resear-- program and directionof= is ntsd.iesexpeced Rh area is open,but prefcrence will be givcn to applicants with epertsein ecological or mokcular parasitology. The s sful

cant wlll have the opportunity to iteract with the;U Hancock Biologaol Station and the Common-

wealth Center for Ecos stem Studies. Application reviewwill begin 1 April 1 transcript(s), threcletters of recommendation, and curriculum vitac to: Dr.Robert E. Danid, Dea to£B al Scencs,Munay StafeU M ,K42071.MSUan EqulO M a n Empoyer

BIOLOGY FACULTLY POSMONMETROPOLITAN STATE COLLEGE

Probaionary full-time faculty position. Earned Doc-torate with an emphasis in human anatomy, and strongsu course work in humnan physiob , or theother-way-around, required. Interest m a teaclung careerrequired; college teacing experience desired. Teachingduties will be human anatomy and human bioogy forVeneral studies students, possibly human physiolOgyintroductory baolgy for scince majors and course(s) marea of spialty. Profiessinal aciity and college andcommumty service required. InT td applicants mustsubmit the follwing to the address given by 1 May1988: Letter of appicaon, curriculum vitae, copics oftranscnpts, three ktters of referece, and a brief state-ment ofhow the person sees hisher rok in undergradu-ate science education

Dr. George Becker, ChairDepto£B - boB53

Denver, CO 80204Meropolitan State Coege is an Equl Opportunisy Em-

phoyer applicaeofiwn minones and women arpartwu-ladyinited. Metropolitan State Colkge does not dis-rimin on the basis of race, clor creed, national

origin, sex, age, or handicap in admissions or access to,or treatment or employment in, its educa vpemsor activities. Inquiries concening Title VI and Title IXmay be referred to: Dr. PercyM e, Jr., Dirctor

Opportunity/Assisto the President,10061th Street, Bo 63, Denver, CO 80204. Tele-phone: 303-556-2999. Inquiries coneng Sction504 nuy be referred to: C, P.O. Boz 4615-P,Denver, CO 80204. Tep e: 303-556-8387. Or,inquirics may be rfe to: ne Office for CivilRlights, US.D tent ofE 1961 StoutStreet, Denver, c080294.

BIOCHBEMISTPOSTDOCTORAL POSMON availabk to study

mechanisms of modification of radiation-induced DNAdamage. Mechanisms to be studied include raction ofthiols with DNA radicals, metal ion catalyi of radicalreactions and charge delcalization by chromatin semi-conductivit. Emphais will be on DNA lesions resultngfm multiple radical at Prncipal model system willbe isolated mammalian cell nuclei. Ecrie with char-acterization of DNA lesions or with enzymolgy ofDNA repair would bc desirable. Project is part of amultidisiplinary program aimed at improving cancertherpy by modifcation of tumor and normal tissuebiochemistry. Send curriculum vitac and names of threereences to: Dr. Edwrd Bump, Dana-Farber Cancer

te, 44 Binney Strect, Room JF 222, Boso,MA 02115. An Ajmirma ActionlEqual OppnyEmployer.

CELLULAR IMMUNOLOGISrThie Dprntof General Surgery at Rush-Prsy

terian-St. ?s Hospital of Ru niversit invitesapplications for a full-tim positaon as assistant professorand associate scienist Intersted appLcants must have anM.D. and/or Ph.D. degre with experience in basictumor and transplant immunology. Ongoing investip-tions include: phenotypic and functional c rof tumor-infiltra ko s, thraputic pontial oflarge granular lympocyts in bone marrow transpiana-tion, flow cyteric analysis of solid tumos, and pre-dictors of rejection in renal and hepatic transplantation.Quaities of the successful applicant should include theability to .pursue a reerhprogram bridging basiclaboratory investigation with clinically relvant problenmin onobgy and trnsplantation. Interested personsshould submit curriculum vitae and three lettes ofrecommendation to:

Steven G. E i M.D., CirmnDepartmet of£Genra SurerRush-Prebtrabn-St. Lukes

Me l Centcr1653 West Congr Parkway

Chicago, IL 60612

UNIVERSITY OF MINNESOTADEPARTMENT OF LABORATORYMECDICINE AND PATHOLOGY

CLINICAL VIROLOGYASSISTANT PROFESSOR (temporary), M.D.,

compktod residency in clinical pathology or intenalmedicine with 2 years of clinical infectious disesestraining beyond residency. Two years of ence ineither diagnostic or research virolgy laboratory Withcxpeicnce in culung retriresD monstltion ofrearch producvity necessary including publications inpeer-reviewed jounals.

Didacic teaching of clinical virobgy to technians,medical and medical technician students, rcsidents andpostdoctoral felows. EExplore interactions of potetialantiviral drugs with HiWat celular kvel and conduct invitro sensitity tesing and syneg studies of combina-tion compounds. Care of HIV-ed patints andconduct clnical trials program. Assistance in daily opera-tion of laboratory and 1 month per year attending onintenal medicine infectious dsase service.Send curriculum vitae, three letters of recommenda-

tion, and synopsis ofrecent research activitics by 30 April1988 to:

Clinial Virolog Search CommitteeBox 198 UMHC, 420 Delaware Street SE

Minneaois, MN 55455The Unemnity ofMi t its an Equal Oppotunity

Eduaor and Employer, *efiayinv and enaui-ages applatioim women and minontie.

CYTOGENETICIST widt expertise in human/othermammalian ctogenetics to join cell culure char a-tion progam. RD responsibilities. Stable support,salary ncgotable faculty position o at MedicalSchool, Waye Stte Uniersity. Respond to: W. Petcr-son, Cdl Culture LaborIar, D fPediat-rics, Chidren's HH o Mic an, Detroit, MI48201. Telephone: 313-745-5570.

SCIENCE, VOL. 239

POSITIONS OPEN P>OSITIONS OPEN

ULLY REEARC LAORATRIESPOSTDOCTORAL SCIENTIST PROGRA

Eli Lilly and CompanyThe LILLY RESEARCH LABORATORIES, a Division of Eli Lilly and Company, is offering postdoctoralresearch opportunities in several areas of biology, pharmacology, and chemistry. PostdoctoralScientists will work in close association with Lilly scientists who are involved in the basic researchprocess of drug discovery. Publication and presentation of results will be an integral part of theprogram. This postdoctoral experience is designed to give individuals in-depth research training ina focused area of biology and/or chemistry. The program will also provide an opportunity to becomeacquainted with the drug development process within the pharmaceutical industry. PostdoctoralScientists will be expected to participate fully in the conceptual and design phases of projects,within the following areas:

Biochemical Pharmacology/HepaticLipid Metabolism

The postdoctoral scientist will study changes in hepatic lipid metabolism induced by drugs andother chemicals. The research will examine the roles of mitochondrial and peroxisomal fatty acidoxidation in the development and regression of fatty changes in the liver, and the relevance ofalterations in lipid metabolism to the induction of peroxisomal fatty acid oxidation. Candidatesshould have training in pharmacology, biochemistry, or related discipline. Experience in lipidmetabolism is preferred but not required.

Muscle Metabolism ResearchScientist with training in muscle growth, muscle physiology, and molecular biology will performbasic research on the regulation and control of skeletal muscle protein synthesis and degradation.The research will examine the effect of beta-adrenergic agonists on muscle protein metabolism.A strong background in biochemistry and molecular biology is desired.

Glycoprotein Structural ResearchThe postdoctoral scientist will use nuclear magnetic resonance spectroscopy and other physical orchemical methods to pursue structural questions relating to protein carbohydrates. The scientist willcollaborate with researchers involved in the structure elucidation of a wide variety of natural productsof pharmaceutical interest, as well as with scientists seeking to evaluate the role of glycosylationin protein function. Experience in applying modern NMR techniques in studies of glycoproteincarbohydrates is desirable.

Recombinant Protein ResearchThe postdoctoral scientist will study the enzymatic cleavage of proteins produced by recombinantDNA technology with the goal of obtaining desired protein products. The scientist must have astrong background in enzyme kinetics and protein chemistry and will have the opportunity to gainexperience in enzyme immobilization, protein sequencing, and molecular biology.

Postdoctoral appointments are of one-year duration and are renewable for a second year withmutual agreement. Candidates with no more than one previous postdoctoral experience areencouraged to apply.

Eli Lilly and Company will provide a comprehensive pay and benefits program includingrelocation expenses.

Qualified applicants should send their current curriculum vitae, indicating program ofinterest to:

John W. CrooksManager, College Relations (PSP)3Eli Lilly and Company

I Illy Corporate CenterIndianapolis, Indiana 46285Equal Opportunity Employer I

POSITIONS OPEN

DEAN OF BIOLOGICAL SCIENCES: State Uni-versiy of Ncw York at Stony Brook: Three research-oriented departmens (Biocmistr, Ecolgy and Evo-lution, and Neurobiology and Behavior) and five inter-disciplinary graduat programs in the Lifc Sciences arecontinuin& their s for an imagintve new lcader.Opportunities exist for sngthening ties with basic andclmical pograms in a large on-campus Health SciencesCanta.biu idcal candidates would have a .ui,edresearch reputation and would possess administativeskills and eerience. Please send curriculum vitae, andthe names of three references to: Chair, BiolgcalSciences Dean Sear Commite, Room 130, Li&Sciences Bui SUNY Stony Brook, Stony Brook,NY 11794 p 1988. SUNY St Brook is anA mtie AonEqu Oppo ity Educator and Em-proyer. AK #66.

DEVELOPMENTAL BIOLOGISTSTwo tenure-eligible assistant professor positions, be-

ginning August 1988, with preferred spdl in repro-ductivebiol and the biology ofaging Ph.D. re-quired. Cndidates should have mollar/celular orien-tations and potdoctol expeience. The successful can-didates will beexpectedto develproductive resarchprgams anoselc mal fimding. They will partici-pate in the teaching prog at the graduate (M.S.),undergraduate, and inructoy non-major kvels on arotational basis. The Deatment of Biolgical Sciencesis housed in a nmxkm well-designed l and suc-cessl candidates will be provided gencrous laboratoryspace and good animal quarters.These positions afford an unusual opportunity for

professional groth through poSsible particpation in ancmerging basic and biomedical research consortium withstrog regional c mitment and suppor

Application deadline s i15Apri 1988 and the 15th ofmonths thereafter until the positons are filled (subject tobudgetary approval). Please submit curriulum vitae,transi , statent of research plans, and names ofthrec references to:

Dr. George IL SweetDepatment of Bi±I0Wal Scences

wichita State nivrtyWihita, KS 67208

The Wichi State Uiveiy is an Equal OpporiylAffirmativeAction Empnye.

DIRECTOR,OFFICE OF RADIATION SAFETY

Washington State University invites applications/nom-inations for the full-time, non-tenured tra faculty posi-tion of Directr, Office of Radiation Safety. Salary$35,000 to $45,000 per year. Position is available 1 July1988. Deadline for applicatio/nomiation is 15 Aprnl1988.Cadidates must hold a master's degree in the area of

health physics, nudcear sciences, radiation safety or relat-ed area, have exerience inhandngof and knowledge ofregulations reating to raoa materials, and havecommunication skills. Ph.D. degree preferred and cxpcri-ence in adminisation and in deahng with users and statecompliance officcrs desirabk. Complc position descnp-tion availabl upon requestScnd applications/nominations (induding curriculm

vitae and names of tree rences) to: Dr. Mack I.Johnson, Asociat Vice Provost forR rch Wash-ington State Universiy, Puinan, WA 99164-1030.Teephone: 509-335-3535.

Rtashigo State Univriy is an Affirmativ Ation/Equal Opportunity Eduator and EmpWyer. Proctedgiupmember are encunagedto appy ad to identi teir sats.

DIRECIOR OF STATEWIDE CTOGENET-ICS PROGRAML Board-certficd or -ligibl ctoge-netist with expenence and interest in molcular bioogyto direct established cytogenics laboratory and iniareplanning for a regional DNA lab. Primarily srviceobligations, butrach stmngly encouraged. The Cyo-genetics and Moecular Cell Biology La atory is aDivision in the D cpartm of Medical Genetics/Mon-tana Medical Genetc Programu Faculty appoiment atMontana State University possible. Salary commensuratewith trammg,u ne and certification status. AnAJwmaitim AaioxnZEqual O y Eoyer. Contact:JohnM. OpitC , Shodair H7ositaI, Boa 5539, Helna,MT 59604. Tdephone 42-1980.

DIRECTORCENTER FOR ENVIRONMENTALRESEARCH AND EDUCATION

Ihis is a new position reuting from an cxpansion ofthe eisig Great Lakes Laboratory. Induded m the newunit are four separatc divisions: toxicological and chem-cal anlysis, fisheries and aquatc ecology, water resourcesplanning, and envimntal oducatioi. The director willwork with faculty and staff fiom d ts in thenatural and social scicnces. Also involed will be thesupervision of the ficld sation on Lake Eric, researchvessels and the various laboratories controled by theCenter.The diector should havc expetse in adminis

public relations, research and grant writing, and havcacademic quaifications in one or more of the arcas inwhih the Center operates. The Ccnter, fiuded by grantsand state appropriations, works closeb with other publicand privatc ageacies such as the U.S. Corps ofEnginecrs,USEPA, Great Lakes United, and other environmentalgroups.

Initial appointment will be for 3 years with opportuni-ty for renewal. Appointment as sa profssor in anappropriate aca de e is possible In addto a significant ringe benefit pacge, pectd salary isnegotiable in the $50,000 range. Anticipated appoint-ment dat is 1 July 1988.

Deadline for receipt of letter of interest, curriculvitae, and names and addresses of three references is 2May 1988. Dr. Joyce SSwartny, Chair of the SearchCommitte, Buffalo State Colklg, 1300 ElmwoodAvenue, Buffalo, NY 14222. Bufao State Cokge is anEqsul Oppounity Empkyer.

ELECIRON MICROSCOPISTHOWARD HUGHIS MEDICAL

INSTrlTUTE ATMASSACHUSETIS INSTITUTE OF

TECHNOLOGYSenior Associate to head major dectron nicroscope

cffort (new JEOL Model JEM-1200EX) directed atunderstanding animal development and behavior, fi*us-ing on the nematode Caeno,*abdutu elegans. Excitingopportunity to use electon microscopy in collaboratonwith other laboratory members cmplying the latesttechniques in genetics and mokcular biogy toaecell-ce dommunicaton, cel deteminaton,morphogenesis, programmed cell death, nerve processoutgrowh, and synapse formation. Ph.D. in utratruc-tural studies and etensive experience with the prepara-tion of serial section electron microgphs prefd.Salary based upon exeine potentially commesrtewith faculty salares.Send statement of intersts, r6sumi, and names of at

least three referenc to: Profesor H. Robert Horwi&z,Howard Hughes Medial Institute at MassachusetInsfituft of ehiF qrm of Biobg,Room S6"62 77 M _ A e, Cam-brkdge, MA 02139.IIHM and MiT ar Equal OppweuniyLAjfirmatiAction Eployers.

EXTENSION VEGETABLE SPECIALISTAcademic carecr-track, 11-month position (75% cx-

tension, 25% research) as extension specialist and plantphysiolgist in the Departmnt of tay and PhntScnces at assistant, associate, or full title level, availabkon or after 1 July 1988. Extension of inrmation andapplicon of research to solve problems in vegetablecr-pninop systems of Sourdthrn Caifoia, and specifica i ties stewide. Research will emphasize thedevelopment of improved management methods and theapplication of plant physiology and ecological principlesto thcontraints inherent in the Califiornia environmnt.Requires a Ph.D. degree, with emphasis in vegetablecrops, plant physiology or cosely related discpline.Communication skills and leadership abilities are essen-tial. Scnd ketter of application, cu m vitae, threeklters ofeference, andtransmipts (rocent raduates) to:Dr. Irwin P. Timg, Chair, De t Botany andPlant Sdences, UJniver o Ca n Riverside,CA 92521. Ihe position will n opn until filledwithp given candidates applying before 15 May1988. The Unvrity ofCufrnia, R rde, its anAffir-mativeAcaiox/qa Oppotunty Emploe. Minri andwomen are encourged to aply.

ECOLOGISTThc Departmnt of Biological Sciences ofthe Univer-

sity ofPittsburgis seekinganestablished scientistwith astrong rcutation in any bran ofeology. Thc success-fil candam will help to dcvcbp the graduate programin ecology and evolution, and will serve as Director ofthe Pymatuning Laboratory ofEcology, a well-equippedfield station lcated 100 miles north of Pittsburgh.Experience in geerating external funding is important,and some inistave backgound would be desirable.The appointment will be made at the klvel of tenuredassociate or full professor, and will be availabk as early asSeptember, 1988. One or two junior appointments willbe made availabk in the next 2 years as a part of thisprogram expansion.

Applications should indude curriculum vitae, copics ofrecent publications, a statement of research interts andfuture plans, and the names and addresses ofat least threcpotential references. Address applications to: EclgSearch Commie, D rtment ofBiobcalSde,UniryOf P g P bh P 15260. AnEqua Oppsaiy fjnaiAaion Enw.

UNIVERSITY OF GUELPHDEPARTMENT OF

HORTICULTURAL SCIENCETENURE-TRACK FACULTY POSMON

IN PLANT TISSUE CULTUREThe Department of Horticukural Science, University

of Guclph, invitcs appLications for a tenure-trac facltyposition at the assistant professor kvel in its Plant TissueCulture Program. Applicants with trwaiinfin plant ge-netics, plant biocemistry/molecular blokgy, plantphysiology, or plant pathobgy who have experience inworking with tisue culture systems and a worinoknowled of Cel transformation, ration and in-cropopagocniques will be given senous consid-

eraton.The ul pplcant will bc pexpoted toestablish a str, Iipet earch prograpi involv-mg one or more horticultural speces, to supervise gradu-ate students, to participate in the D armetal under-graduate and grduate teaching prgrams and to interactwith the horticuiural industry. Salary will be commensu-rate with qualifications and eperience. Applicatonsincduding curriculum vitae, a statement ofresearch inter-ests,and the names of three refcrees should be sent to:Dr. J. B. , aman D t ofHor-icultural i G h, Gup4 On-tario, Canada, NIG 2W1. Thec date for receiptof applications is 31 May 1988, or when the position is

In accorAnce with CanadianImratpnoy wil be given to Canadian c*iem permaentesdents ofCaada.Subject to final budgtary approval. The Unirsity of

Guelp is wmmitt to Enlyeen Equity.

UNIVERSITY OF GUELPHDEPARTMENT OF

HORTICULTURAL SCIENCETENURE-TRACK FACULTY POSMON

IN PLANT BIOTECHNOLOGYThe Department of Horticultural Science, University

of Guelph, invites applications for a tenure-trac facultyposition at the assistant pfssor levd in Plant Biotech-nology. Prece wil be given to candidat withtraining in plant bioch it and experienc in recombi-nant DNA tchnolg incuding the isolation and char-acte.ation of plant genes, the synthesis and isolation ofcDNA and plant cll tansoation. The succsfulapplicant wilbe exctd to establish a strong, indepen-dent research program inolving one or more horticul-tural species, to supervise graduate studets, to partici-pate in the Depart al undegrduate andtaching programs and to interact with the horticultralindustiy. Salary will be commensurate with qualificationand experience. Applicatons including curnculum vitae,a atement of research in s and the names ofthreerefcres should be sent to: Dr. J. B. hmpson, Chair-man, Dertm t ofHo l iene, Universi-ty ofG Guelpi, Ontario, Caada, NlG 2W1.Ihe dosing date for receipt of applications is 31 May1988 tordnthe ponimionis firled e

iEn a aCoia Ixwratioprority wil bhegi to Canadin cies andprannradents ofCanada.

Subject to final budgetary approvaL The Univs ofGuepb is acmmis to EmoymentEquity.

SCIENCE, VOL. 239

POSITIONS OPEN P-OSITIONS OPEN

DRUG METABOLISMBiomeasure, Incorporated, a companydedicated to the development of therapeuticpeptides, is offering an excellent oppor-tunity for a Biochemist with the followingcredentials:

* PhD with 3 to 5 years postdoctoral oririal aperience in drug metbbolism.

* A proven ability to design and conductstudies on absorption, distribution,metabolism and elimination oftherapeutic peptides in animals andhumans.

* A working knowledge in instrumentalmethods of analysis, computer modeling,radioisotopes handling techniques andradioassays.

* An interest in drug delivery systems.* An outstanding record of scientificaccomplishments.

* Familiarity with regulatory issues (GLP).* Excellent communication and interper-sonal skills.

Located near Boston, Biomeasure providesstate-of-the-art facilities and a supportiveenvironment for the conduct of research.Excellent compensation, benefits andrelocation package available for qualifiedapplicants.

Send resume and salary requirements inconfidence to: A

Human esourcesrBiomeasure, Inc. An affirmative action!11-15 "E" Avenue equal opportunityHopkinton MA 01748 employer m/f

_~ ~ ~ ~ ~ ~

Cell Biology ResearchIThe Upjohn Company, a world leader in the research and development ofpharmaceuticals, has an Associate position opening in cell biologyresearch. The position requires a BS or MS degree in Biochemistry, CellBiology or related discipline and involves studies of glycoprotein transportand processing, with emphasis on the structure and function of theoligosaccharide chain. Successful candidates should have knowledge andexperience in protein isolation and characterization, including state-of-the-art liquid chromatography methods. Experience in tissue culture and/orglycoprotein analysis is desirable.

The Upjohn Company is located in Kalamazoo, a mid-sized community insouthwestern Michigan, midway between Chicago and Detroit. The regionis surrounded by rolling hills, lakes and woodlands and provides im-mediate access to a wide variety of cultural and recreational pursuits,ranging from concerts and theater to a full range of summer and wintersports. Upjohn offers an excellent package of salary and benefits in a com-munity with a reasonable cost of living. For confidential consideration,please call from outside of Michigan toll free 1/800/253-8600,ext. 3-6767, (inside Michigan call collect 616/323-6767) to request anemployment application be sent to you immediately. Please refer to posi-tion number 22110-2A when calling. We are an Equal OpportunityEmployer M/F.

Our Commitment To ScientificExcellence Continues...

I

MAIZE MOLECULARBIOLOGY

We are seeking an innovative andstrongly motivated scientist to join on-going research on maize plant trans-formation and regeneration. Quali-fied applicants should possess the fol-lowing:* Ph.D. in Cell or Molecular Biology,

Genetics or related field* Research background in Plant

Molecular Biology; experience inPlant Cell Biology and Tissue Cultureadvantageous but not required.

* A record of scientific achievementincluding original publications

* A deep interest in exploring cellularand molecular parameters affect-ing gene transfer and expression Inmaize

* Willingness to interact with interdis-ciplinary team involved in maizetransformation

Calgene is a leading plant biotech-nology company located in Davis,Calfornia. We offer an excellent com-pensation package as well as a pro-gressive research environment andgrowth potential.For consideration,send resume andcover letter to: Cal-gene, Inc., File P500,1920 Fifth Street,Davis, CA 95616. EOE CALGENE

Australian Research Council

.b4^TRLl~QUEEN ELIZABETH 11 FELLOWSHIPSThe Australian Government has established the Queen Elizabeth II Fellowships to encourage research byyoung scientists of exceptional promise and proven capacity for original work. Under this Scheme, 15awards will be made annually. Fellowships may be taken up in industry, universities, colleges of advancededucation or government research organisations in Australia and are normally for three years. Tenure of aFellowship is expected to commence within nine months of the announcement of the award. The awardsare for high quality research work in one of the three categories described below:1. FUNDAMENTAL RESEARCH2. INDUSTRY BASED RESEARCH3. RESEARCH IN PRIORITY AREAS OF NATIONAL INTERESTPriority areas of National Interest may include:* Energy Technology * Occupational Health anc, Safety* Information Technology and Communications * Marine Sciences and Technology* Materials Technology - Environmental Sciences including Ecology and* Manufacturing Technology Natural Resources* Raw Materials Processing * Aboriginal Affairs* Scientific and medical instrumentation * Citizenship and National Identity* Projects jointly sponsored with industry * Income, Wealth and Social Inequality* Biotechnology * Social and Economic issues concerning;* Trade, particularly with Asia -addiction* Productivity -aging* Business Organisation, Management and -training and employmentIndustrial RelationsQUALIFICATIONS Fellowships will be awarded to persons holding a Ph.D or equivalent qualifications, orequivalent research or professional experience. The decisions regarding equivalent qualifications will bemade on a case by case basis. Recommendations for the award of Fellowships will be made to theMinister for Employment, Education and Training by The Australian Research Council. Awards will, ingeneral, be restricted to applicants who are not more th3n 30 years of age when applications close; butconsideration will be given to older people with less than five years post doctoral experience who havehad an interrupted or late start to their academic career.ELIGIBILITY' Fellowships will be awarded on merit to suitably qualified persons.SALAR. $29,632 (Australian) per annum - increased to $32,127 per annum at age 28 years.TRAVEL EXPENSES Necessary travel expenses are payable.RESEARCH SUPPORT GRANTS: An additional supporting grant of up to $3,000 per annum to help coverresearch costs is available.APPLICATIONS Persons interested in applying for the above fellowships should obtain application formsand a statement of the conditions of award from: Director, Research Grants Section, Research Policy andGrants Branch, Department of Employment, Education and Training, PO. Box 826, Woden, A.CT. 2606,Australia.The next round of awards will be announced in October 1988. Applications received after the dosing date8th April 1988 will not be considered.

m

POSITIONS OPEN

FACULTY MEMBER-MOLECULARB PATHOGENESIS

The Division of ifectious Discases ofthe Deparmentof Medicine at University Hospitals and Case WestnReserve University is seekin* a raculy member trained inmolecular padthgenesis. hlis person would join a teamfcusing on host-parasite interactions ialinfections (M. eoir, M. ay*m). Tntradionalemphasis of this group has been regulation ofthe cellularimmunc response and mononudear phagocye cffcctormechanisms. The new faulty member woulpartcpatein studies to dcfine myAcbatial constituents assowith virulece and icellular parsm and oseengendering a rotective immune e. CWRU is anAfermatireAason/Equ2l Opportunity Empoyer. Send cur-riculum vitae to: Dr J. J. Ellnr, rtment ofMdicine, U ni Hoqtals, 2074 AbingnRod, CkveLnd,OH 441

THE UNiVERSITY OF CALIFORNIAAT SAN FRANCISCO

FACULTY POSMON INDEVELOPMENTAL BIOLOGY

Candidates are sought for a tenure-trac faculty posi-tion at the assistant professor leve, but appointments at amore senior level will be considered. Th successfilaplicant will bc expected to conduct a resarch proramthat combines classical, genetic and/or molecularpraches to problems in developmetal bioloy. I additio4 partpation in the tehing actviies ofthe Gradu-ate Program in Deopmental Bigy and theAnatmDepartment will be expee Appicant should sendcurriculum vitae, bibliography with copies of publica-tions, a summary of arc plans, and names of threescientiss Willing to write letrs of rcmmeation to:

<Bai 1k_mnta Biov Seach Com-mittee, Department ofAnatmy, Uniery of Ca-furnia, San Francisco, CA 94143. plications uldbe recived by 15 April 1988. UnvMy fCai SanFrainco, is an Equal OppulAfr _A Em-ploycr. Wom and o eatt apply.

FACULTY POSMON INEE RESEACH

The Dpartment of0 hthaLolom y ofDukc Universi-tyMedical Center is seing an individual for a researchfa>culty ositio. Applicants should have hadpo r-al tramming and a demonstrable ability to estblish astrog and creativc progam in y research prefrably,but not necessarily, in an area related to cel biology.Applicants arc especially sought who can apply modemmethods of cellular and molecular bioloy to basicproblems in ocular pathobiology. The appoee will becqexcted to intert with the clinical anr h facultand to participate in taching. A joint apmtment witha basic science department at Duke Uiversity will bcequird. Rank and salary will bc commensute with thequalifications of the succesful candidate. Interested ap-plicant should send curriculum vitae, a statement ofreseach plans and objectves, as wel as three letters ofreference to: Dr. Gordon L Klintworth, Duke EyeCenter, Duke University Medical Center, Durihm,NC 27710. Duke Unxipiy is an Eqal OpporuiylAJfinnativeAaion Empoyfr.

GENERAL PHYSIOLOGISTS. Two Ph.D. ten-ure-rc assistant professohips available 15 August1988. Un uate and gradute tdaing in normaland abnoml human and systems phiology, advising,and limited research eations. Salary competitive.Send statement of interests and goals, rum, tran-scripts, and three letters ofrerencebf 11 April 1988 to:Physology S ch mitt Biologcal encesDeartment, Sabry State Colge, Salisbury, MD21801. Salsut State Cdlege is anA Jin ActioniEqual 0,eic Emper Qual~dwmn uots

GENETICS/BIOMETRICS. VISiTNG ASSIST-ANTPROFESSOR fiom August 1988 to May 1989 totmch undergraduate genetics with labs, and appliedstatstics. Ph.D. required. Send curriculum vitae andthree letters ofcvaluation to: Genetics Search Commit-ate, B Deprtmt, Coll William andMry, WilimVA 23186. Rciws begin 15Aped 1988 until ition filled. An Eul OlsortunisylAJUaVA CUUmpoer men anmm nexecour-

to appl.W

I160

POSITIONS OPEN

FACULTY POSMON INEYE RESECH

TheD nt OphOhtl ogyofDuke Univrsi-ty Modical Center is seeking an established vision re-searcher with pee-reviewed fimding from the NatonalEye Institute to join its resarch faculty. Applantsshould have a creative ongoing reserch program prfra-bly, but not nessari, in an area rdated to cell biolog.Theapointewil imeted tO inter= i

faculty and tO participate i teahiing. Rank and salarywill be commensurae with the qualifins of thesuccessul candida. Interested applants should sendcurriculum vit, a statent of ps andobjectives, as well as three lrs of tO: Dr.Gordon L Klintworth, Duke Eye Center, DukeUniversity Medical Center, D m, NC 27710.Du*e UniyanEqual Oppotuni yAffrmpativeActionEmployer.

HUMAN GENEICISrImmediate opening for a Ph.D. with interest in molec-

ular, biochemical, population, or c cs. Responi-bilities inchlde the development of an independt re-search progam and to provide administrivc sppofor the Human Genctic Mutant Cell Repository.-icurriculum vitae, statement of rsarchinests, and thnames of th refrences to: Dr. GenrdM cGPresident, The Coddl InstitutefrMelR cCopewood Stret, Camden, NJ 08103. AjirmativeAgonEqul Emplyme Opportuxity.

ICHTHYOLOGYSCIENTMIC ASSISTANT

The Deprtnt of Ichthyology of the AmericanMuseum of Natural History is s&king an assistant topaicipate inits research progams and activites. Re-sponsibilities will in e assistng in data collecdon,identification ofspecimens, preparation ofresearch mate-rials, and the preparation andm t of the De-partment's coalcton of preserved fishes and skektns aswell as the maintenance of deparmaental facilities.Quafied candidates must have a baccalaureate degree

in the biolgical sciences, some buckbound in ichthyol-ogy, ep in handling scientic collections andequipment, manual dexterit, and be detail-oriented.

Salry $19,534 per annum plus excelient benefits. Fora , please~ submittacurrkulum vite to: Mr.

MIAmMusesm of Natural History, Central Par West at79th Street, New York, NY 10024.AnE Opportu-nxty Ex*loyer.

INVERTEBRATE VIROLOGYPostdoctoral position availabk to study the mokcular

gacs of aculoviruses. Research involves regulation oflae gene expression and the construction of genetcallyengined viral pesticides. Position availabk immediate-lyfor candidates with a Ph.D. in entomology, microbiol-opy, biochemistry, or related ficld Experience in recom-binant DNA techniques required. Previous cxince ininsOct or virs research not neceary. Send curriculumvitae and names ofdtree refences to:

Dr. IL Alan WoodBoyce o mInstitute

Cornell UnvrstTower Road, Ithaca, Nt 14853

Boye Topo=Intiu is anAAiasActiA , EqualOpprtunity EmXpyer.

NEUROBIOLOGISTTwo postdoctral positions are available immediately

in a mutiipinary laboratoty for individuals interest-ed in pursuig studies on the functions of astrcytes.One position involves xamniation of tontic respon-siveness using a video-based i isystem to monitordcnges in intracellular ions via f probes. Thesecond position involves isolation of pharmacologialldistin subpopulations ofastrocytes, and examination offactors reLsed from astrocyts following receptor stimu-latio. Individuals intsted should have a strong back-ground in biohhmistry and pharmacology. Send curric-lum vitae to: Dr. Ken D. M cC , tmn of

27599-7365 Eqat OparduitChapyEm loy27599-7365. Equ^l60~ Exsplyer.

POSITIONS OPEN

UNIVERS1T OF QUEENSLANDEqu Opprty in Empkonn is Unienay Po&iry

LCTURERSENIOR LECTURER(TENURABLE)

DEPARTMENT OF ANATOMYApplicants should havc a higher degree and/or profes-

siona qlifications, and significant postdoctoral rc-search eince in an area of comparativc anatomy orbiology.The Appointee will make a substantial contribution to

the teaching of comparative anatomy to veterinary sci-ence stdnt.

Salary: Senior Lecurer $37,903 to $44,091 per an-num; Lecturer, $28,380 to $37,122 per annum. Closingdate: 30 April 1988. Reference No: 10088.

Additional informaton and application forms areavailabk from: lTe Director, Personnel Services, Uni-ersity of Qu and, St. Lucia 4067, Queensland,

AustraliL

MEMBRANE SKELETONPOSTDOCTORAL POSMON availabk to study

the stucture and function of a novel, recently identifiedpomoin-bi i fom the crythroct mcm-

branc s [V.k Fowler, J. Bil. CIem. 262,12792-12800 (1987)]. Possibk projects indude (i) mo-lcular cloning and seque g thie genefor this proteinand the deveopment ofa cellr expression systm, (ii)characterixation and immunolocali:ation of analog(s) tothis protein in non-eytroid cells and issues, incudingbrain, lens and skeletal muscle, (iii) analysis ofthe rok ofthis protein in assembly of the spectin-actin membraneskeleton and tropomyosin regulation of actomyosinATPase activity. Salary: $18,000 to $22,000, dependingon cxperience. Candidates who have recently completedthir Th.D. thsis, or who t to do so soon, arcpularly en rag to app. Send curriculum vitaeand names of three nces to: Veia M. Fowler,

D of Moleular Biology, MB14,Of Scripps Clinik, 10666 North

Tonrr Pines Road, La Jolk CA 92037.

MICROBIO IBASIC SCIENCES-MarquettUniversity School of Dent6isy has a fill-time, tenurc-tk faculty position available at the ASSISTANTPROFESSORItevel 1 September 1988. Applicants musthave a Ph.D. Posutdctral research and teaching exper-ence is desirabk, but not required Candidates are expoct-ed to partlipate inthdepart teaching ofdenta andalLied health students as well as to establish a strongresearch program. Opportunities are available to interactwith the faculty in the other basic sciences. Salarycommensurate with education and experience. Review ofapplications will begin immediately and continue untilpositon is filled. Applicants should send dteir curriculumvitc, transipts, names and addresses offour referencesand a tatement of their resarch interests to:

Dr. Howard M. Aiirmaad,Caianof{Basic Scienscs

Marquette Universiy School of Dcntistry604 North 16 StreetMilwaukee, WI 53233

Ma ste Unwen5y is an Equal OpporunPiyLAffinna-timeAtion Employer.

MOLECULAR BIOLOGISTThe Deparutm of Pathobiology, College of Veteri-

nary Mediine, Aubur University invites applicationsfor a tenurc-track faculty position. Applicants shouldhave strong iing and significant srch xeriencein the molecular or genetic aspects of infectious disease.A Ph.D. degree and postdoc research experience arerequired; demonste ability to obtain extramural re-search fimding and rsarch expeience in vctrinarymicrobiology are desirable. The successfill candidate wilbe expcta to develop a strong independent researchprogram, contribute to colliborative research projand paripate in graduate training programs. Sal andrank com e with training and experienc. Appli-cation deadline is 31 May 1988, or unti the position isfiled; position available 1 July 1988. Applicants shouldsubmit curriulum vitae, summary of current researchactivities, and names of three refcrences to: Dr. LaurenG.WofDept OfPathobioklog,Auburn Uni-verity, AL 36849. Aubu Uniity is an Equal Em-ply i Emplyer. Minrti axd womn arencm ed as apply.

SCIENCE, VOL. 239

Our client is a Montreal based Canadian affiliate of a major muftination-al organization in the pharmaceutical industry.We are seeking qualified candidates to fill two positions in the ScientificDevelopment Group. Individuals selected for these positions willendeavour to obtain collaboration of leading specialists interested inresearch projects relevant to the company and also communicatescientific information to and from clinical groups within hospitals anduniversities. Candidates must be prepared to travel as necessary.Proficiency in both English and French will be considered an asset.The ideal candidate will:

* possess a Ph.D./Pharm.D./M.D.* have minimum five years post-doctorate experience and have

developed a professional reputation in their field.* possess excellent oral and written communication skills.* demonstrate an interest in or exposure to cardiovascular disee

or Immunology. Highly qualified individuals in other areas will alsobe considered.

* possess good interpersonal skills.A competitive compensation and benefits package will be offered tothe right candidates. Interviews will be held in North America andEurope.PLEASE ADDRESS ALL ENQUIRIES QUOTING REFERENCE#87036 TO:

... ._16

am

Can ivc d

Dr. Marc C. RahelaCanMed Consultants Inc.659 Mississauga CrescentCanada L5H 1Z9Telephone (416) 274-0707

< XWecton Dickinson Immuno-cytometry Systems devel-ops and markets,on aworldwide basis, sophisti-cated flow cytometryinstruments and reagentsystems used for cellanalysis.

Manager,ApplicationsSupport GroupFor this highly visible position we require theexpertise of a seasoned professional with ex-tensive practice to manage aplications lab-oratories for our company in Braintree,Massachusetts and Mountain View,California.The professional selected will posses a solidworking knowledge of advanced biomedicalinstrumentation and computer technologycombined with extensive knowledge in clinicalimmunology and flow cytometry.These qualities are essential as you willmanage an accomplished Applications groupresponsible for the development of applica-tions procedures utilizing software, instru-ments and reagents which are manufacturedand/or serviced by our company.Specific responsibilities will include initiatingannual budgets; analyzing and selectingequipment; and formalizing and implementinggroup objectives, policies and procedures.Additionally you will facilitate the training ofour Customer Support Groups as well asassist the Customer Education Department inconducting workshops, symposiums andseminars.Your credentials should exhibit a PhD in bio-physics, biochemistry, immunology or arelated discipline, 8 years of post doctoraltraining in an academic institution or biotech-nology industry combined with 4 years in amedical/diagnostic environment and 4 yearsof management or experience in a supervi-sory capacity.Becton Dickinson offers competitive salariesand an excellent benefits package. Forimmediate consideration, please send yourresume to Manager, Human Resources,Becton Dickinson ImmunocytometrySystems, 2375 Garcia Ave., mouritainVIew, CA 94043. An Equal OpportunityEmployer.

EC1PN

A CareerWith Rasults.

Syva is a subsidiary of Syntex and a leader in the medicaldiagnostics field. We develop, manufacture and market teststo diagnose infectious diseases and detect drug levels. Cur-rently, we have openings in our Research and Developmentgroups for talented, creative scientists.

ResearchWe're looking for a Senior Scientist to conduct new researchprojects in our Molecular Biology group; working in DNAhybridizations assays for infectious diseases. A PhD inmolecular biology/related field is required with at least 2years' experience in protein isolation, yeast cloning andrecombinant DNA technique.

DevelopmentWe're looking for talented scientists experienced in assaydevelopment to work in a challenging team environment.Positions are available at the BS/MSlPhD levels, which requirestrong analytical biochemistry skills, and experience in proteinmodification and purification, as well as immuno-diagnostics.Syva offers an attractive benefits program that includes anincentive bonus plan and generous relocation assistance. For

prompt consideration, pleasesend your resume, indicating

) ~_ position of interest, to: Syva,Professional Staffing, Dept.yvJ_DP/S, P.O. Box 10058, Palo

A Syntex Alto, CA 94303. An equalASyntex opportunity employer.Company

I

c la

L i

POSITIONS OPEN

MICROBIAL ECOLOGIST: A position for a post-doctoral research associate will be available 1 July 1988for 2+ years. Interests in physiological ccology or bio-geodhemistry ofmarine benthic systems ,ferred. Expe-rinenc with biodegradation and ana== helpful butnot necessary. Send application, curriculum vitae, andthree letters of refirence to: Dr. G. M. King DaringMarine Center, University of Maine Wapoe, M04573 by 8 April 1988. An Affwsaric Action/EqualOppwtunity Emplyer.

MOLECULAI BIOLOGYASSISTANT OR ASSOCIATE PROFESSORA tenure-track position is availabl for an individual

interested in studying protein toxins that act on thencrvous sysem. Suc l applit will join a multi-dicipliaiy team composed o invesgators from mcdi-cine, microbiology, pharmacology, physiology, and ncu-robgy. Prfence will be given to appliants who areskilld in the areas of sequencing and primary structuredetermination, site-directed mutagencsis, and in situhybridization. Interestcd person should submit curricu-hlim vitae, list of publications, synopsis of research goals,and names of three rcfcrences to: Dr. Lance S'Jefferson Medical College, 1025 Walnut Stret,adephia, PA 19107. Equal Opponnity Empklyr.

PALEOZOIC INVERTEBRATEMACROPALEONTOLOGIST

U.S. Geological Survey, Branch of Paleontology andStra hy, announces vacancy for invertebrate macro-paleontologist to study lower and/or middle Paleozoicrocks. Prefer applicantwith Ph.D.; must bc U.S. citizen.Preferepic field ented saer specalizingin establshed biostratigraphically usefil fssi gro(s).Salary and gradc negotiable based on career experence(salary range $33,21-8 to $60,683 per annum, GS-12 tGS-14). Duty station will be determined at time ofselection.Scnd application to: A. G. Harris, U.S. Googical

Surve, ES. National Musem, E-501, Washin,DC 20560. Telephone: 202-343-3495 by 15 April1988; must include Standard Form 171 (Personal i-fications Statement) available from above address or anyFederal pernel office and complete list of publica-to.The U.S. Gea&yial Surey is an Equal Oppornity

Employer.

PHYSIOLGIST/PHARMACOLOGIST-The De-partment of Physiology and Pharmacology of Thc Uni-versity of South D;lota School of Medicine invitesapplications for a tenure-track position as assistant/asso-cate professor. A Ph.D. and or M.D. degree and aminimum of 2 years of postdoctoral experience arerequired. Prefcrence will be given to candidates withexperience in autonomic-cardiovascular pharmacology,endocrinoogy or molecular biology although candidateswith expertise in other areas will bc considered. Selectionwillbe based on scientific credentials and the potential toestablish an outtanding independent research program.Excellence in teaching is cxpected. Salary is negotable.Applicants should arrange to have their curriculum vitae,and namcs of three refercnces, and a statement of re-search interests scnt to: airman, Depatment ofPyand Phamclogy, The Ufniverity of

South D,School of Mlmediie VermillIon, SD57069. Closing date for applications is 1 June 1988, oruntil position s filled. AffirmtiveActonEqal Opporu-nity Exciyr.

PLANT GENETICS/SOYBEAN. Applications areinvited for a tenure-track ASSISTANT PROFESSORposition (80% research, 20% teaching). A Ph.D. degreen plant genetics or a related field, and a thoroughknowledge of fundamental geneics at the whok plantand moleular level is required Research will be directedtoward soybean improvement. Participation in the genet-ics teaching program is expected. Direct applications to:Dr. AL W. Phillips, He eD t ofA yPurdue Universty, West Lete, mN47907. In-clude a r6sum4 transcripts of all U rsity degrees, andthree ktters of mmendation. An Equal Opotunity/AffirmativeAction Empfoyer.

i562

UNIVERSITY OF GUELPHPHYSIOLOGIST

The Department ofAnimal and Poultry Science at theUnivcrsity of Guelph is secking applications from physi-ologists who wish to apply their experise to study theresponse of poultry to their environmnt. Minimumrequirements are a Ph.D. or equivalent in physiology.The succssful applicant will be expected to develop anactive research program integra the principks ofphysiology and ethology andto apply these pnciples tothe objectiv cvaluon of pouity production systems.Evidence of ability tOliaise with industry will bc an assctIn addition the incumbent will bc cxpected to develop astrong teaching progrann at both undergraduate andgraduate levels in his/er area of competence with appli-cation to livcstock production.The position is tenure-traack at the assistant/associate

professor rank in a department with expertise in thedisciplines reting to the care and management ofanimalspecies of agricultural importance. The appointec shouldwork csdely with colleaxs in both the agicultural andveteinary akrgcs.TiecJniMsity is internationally rcc-ognized for itsleadership in ethobgy.Complete r6sumc and names ofthrde references should

be sent to:Dr. R J. Etches, Chairman

Deprment of Animal and Poultry ScienlceUnmiverst of Guciph

Guelph, Ontario, Canada NiG 2W1The cbsing date for applications is 30 April 1988.Position su-bject to final budgetary approval.

PHYSIOLOGIST for hospital in norticast Ohio toresearch effects ofexperimental drug agents on myocardi-un following coronary artery occlusion and rperfusion;collect and iterpret data; prepare findings for publica-tion ifwarrant. Requirs M..in physiolo, or M.Ddegree (or forign degree detemnined to be equivalent toU.S. degree by approved credentials evaluation agency)and 18 months o-fexperience, either in job described orin investugation and supprcssion of afrhydtmia in hcartdciseas nd physiokgy of heart, including 1 year inclinical cardiology and doing Holer monitoring. Musthave published two research artidcles in areas of arrhyth-mia and Hokter monitoring. Forty hours per week, 9a.m. to 6 p.m. $23,550 per year. Qualified applicantsreply immediaey with risumr to: R. Lech,i, JO#3032218, Ohio Bureau of Emplyment Srvices,P.O. Boa 1618, Columbus, OH 43216.

POSTDOCTORAL ASSOCIATE: NIH-fuidedproject to study the neuroanatomy of the brain stengustry sys. Experiments involve EM-HRP andauoradiogaphy. Experience in neuroanatomy, iumun-Ohi it or neurophysiolgy desirable. Send cur-riculum vitae and statement of research interests to: Dr.Mark C. Whitthed, Th Ohio Sate University,Cdkge of Dentisty, Department of Oral Biology,305 West 12th Avenue, Columbus, OH 43210.

POSITDOCTORAL ASSOCIATEosition isavailabk immediately for rescarch in cellular motilityutilizing microinjection and laser-microsurgery. Re-search will involve basi mechanistic studies ofmotility inParum amoeboflagllates and amphibian melano-phores. Gencral backround in cell biology is required,and experience inmicroinjection technology ishiflydesirable. SalaryisS20,000 per annum (plus fnngebenefits). Send curriculum vitae and three letters ofreferenec to: Dr. Mark B. Ademan, Departmt ofAnatomy, Uniformed Services Univity o theHeh Sciences (USUHS), 4301 Jones Br Road,Bethesda, MD 20814-4799. The USUHSis EqualOppounity/AffirmeafieAaion Exployff.

POSTDOCORAL FELLOW: Cellular pharmacol-ogy ofprolactin related to proliferation, drug effect, i.e.,TCDD and cyclosporine on reccptor binding, PKC,omiitine decarboxylase. Cell culture, RIA or EIA, West-cm and Norhrn blos. Opportunity to uncovcr newinsight into cell function related to proliferative diseases.Salary commensurate with NIH guidelines. R&sumi to:Diane H. Rossll Ph.D., Chair, Dparrtment of Phar-maco and T cs, Univmity of SouthFlorida College of edine, 12901 30th Street,DC9, Tam , FL 33612.

POSTDOCTORAL FELLOW MOLECULARNEUROBIOLOGY. A position immediately availablefor study ofmolecular biology of glycoproteins involvedin ncuron-glia interactions, myclination, and demyelin-ation. Studies indudc determnation of gene structur,structure-function relationship and regulation of alterna-tive splicing. Techniqucs indude DNA sequencing, invitro mutLagLenesis, and in vitro DNA amplification.Candidates should have some expcrience m protcinbiochemistry and/or molecular biology. Send currnculumvitae and ktters of refcrence to: Dr. Kari Stefainson,DIpartment of Neurolog, University of5841 South Maryland Avenue, Chicago,Telphonc: 312-702-6387.

POSTDOCTORAL POSMON available to stcell cycle control ofDNA replication and cellular aging inyeast. Research involves techniques in mdecular andyeast genctics, and indudes analysis of proten-DNAinteractions and genc expression. Send curriculum vitae,including bibliography, and names, addresses, and tele-phone numbers of three refcrences to: Dr. S. MichalaJwinsi Depa nt ofBiohemist and Molecu-hr Biolgy isna State Univerity Medical Ccn-ter (ISUC), 1901 Perdido Street, New Oreans,LA 70112.LSUMC is anEqual Exkyment Opporuity/AffinaiveActim Employes.

POSTDOCrORAL POSMONCASE WESTERN RESERVEUNIVERSITY (CWRU)

DEPARTMENT OF MEDICINEAND BIOCHEMISTRY

The Division of Pulmonary of the Department ofMedicine and the Departm t of Biochemistry at Uni-versity Hospitals and Case Westem Rcserve Universityare seeking a postdoctoral fellow with experience inmokcular biologic approaches andptein bioheit.This person would join a multidisciplinary team. Thetraditional emphasis of this group hasbeen rcgulation ofthe cellular immune response and mononuclear phago-cyte effectormechan. The postdoctoral fellow wouldparticipate in studies to define macrophage-surfactantinteractions associated wtih immune regulation of thelung. CWRU is an AffimnatieAaion/Equal OEmployer. Scnd curriculum vitae to: Dr. E. A. Rich,Department of£Medidine, Unive Hotls, 2074Abington Road, Ckveland, OH 106.

POSTDOCTORAL POSMON available to studythe physical prperties and molecular biology of thesomatostatin receptr. Background in biochemitry ormolecular biology required. Salary is negotiable. Sendcurriculum vitae and fetters of recommendation to: Dr.Terry Reisine, 103 John Morgn Building, Depart-ment of Ph colgy University of Pennqs iaSchool ofMediane, P1ieIpI,PA 19104.The Unirsity ofPennsyl irai an Equl Opporuity

Emplyer.

POSIIDOCTRAL POSMON available immeodi-ately for cloning and characterizing genes exsduring pollen development. One year, with possibilityfor extension Recombinant DNA experience required.Salary $20,000 to $21,000. Send curriculum vitae andnames of three references to: Dr. Joseph P. Mascaren-has, DP t of Bioloical Scences, State Univer-sity ofNew York at Arlay, Arlny, NY 12222. AnEqual Opportunity/Ajnrative Acton Employer. Applica-tiom fom women, mirit po, c d pemos,and scial diabd or Vietnam era vters ae cwdom.

POSTDOCTORAL POSMONS (three) availableto study molecular and/or evolutionary genetics ofDo-sphila. Roles of cis- or trans-acting eleents, DNA-protein interactions, and chromatin structure will bestud in two systems: (i) Adh in cell lines (Benyajati);(ii) Thc Responderlocus ofSegregtion Distorter (Wu).SD project has a population genetic component. Ph.D.in genetics, molecular biology or biochemistr is re-quired. Contact: Drs. C. Bcnyaja or C. Wu, D t-mnt of Biology, University ofRochester, RochesterNY 14627.

Equal Opportunit EmplryrMF

SCIENCE, VOL. 239

POSITIONS OPEN POSITIONS OPEN

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%JCIICLI%w)Is ResearciAtIts BestAs one of the premier biopharmaceutical companies in the UnitedStates, the research opportunities at Genetics Institute are un-paralleled. Collaborating with the most respected scientists in thefield, you will work on the leading edge of today's most innovativeapplicadon of scientific discovery - the development of humantherapeutics through recombinant DNA technology.In addition to the dynamic strides we've made in the research anddevelopment of these therapeutics, we have the capabilides toperform large-scale clinical manufacturing which affords our scien-tists the unique opportunity to watch their findings develop fromconcepdon through completion - that is research at its best.

PROTEIN PURIFICATIONWe are seeking a creative indMdual to develop purification schemesfor novel pharmaceuticals, such as blood cell differentiadon factorsand thrombolytic agents. Suitable applicants will have a Ph.D.degree, a strong background in protein biochemistry and exten-sive experience in protein purification. The position carries directresponsibility for developing procedures for purification of bothbacterial and mammalian expressed proteins, up to the point atwhich clinical production commences. Beyond this point there willbe on-going responsibility for biochemical aspects of the large-scaleproduction process. It is essential that applicants for this keyposition have an understanding of purification scale-up and theability to effectively interact with personnel in other disciplines, especiallyengineering and production. There will also be considerable opportunity to interactwith peptide and carbohydrate chemists, as well as cell biologists, In exploringstructure/function relationships of proteins of interest.

STRUCTURAL PROTEIN CHEMISTRYOpportunities exist for motivated and talented individuals at all levels (B.S., M.S.,Ph.D.), Ideally with backgrounds In structural protein chemistry, e.g., proteinsequencing, amino acid composition analysis, pepdde mapping strategies andprotein modificadon. However, candidates with strong chemistry backgroundsand skills in analytical chromatography and instrumentation will also be considered.This position will offer scientists the challenge of interacting with experts in otherdisciplines (e.g., mass spectrometry, carbohydrate chemistry, protein biochemistryand cell biology) and the responsibility for taking a project from conception tocompletion.

BIOPOLYMER MASS SPECTROMETRYWe are currentiy accepting applications from scientists with expertise in massspectrometry to undertake projects involving the characterization of mammalianand bacterially expressed proteins. Candidates must possess a Ph.D. in a chemicalor biochemical discipline and appropriate training and experience In biopolymermass spectrometry, preferably with sector-type instrumentation. Responsibilitiesinclude the development of novel instrumental and chemical mass spectrometricmethods to define the protein and/or carbohydrate structures of cell differentia-tion factors and thrombolytic agents. The successful candidate will be expectedto assume responsibility for the planning and execution of scientific projects. Sincethis position Involves substandal interaction with sciendsts from other disciplines,applicants must have strong interpersonal skills as well as excellent oral and writ-ten communication skills.Genetics Insdtute offers an attractive compensation and benefits package in-duding equity pardtcpaton and an excellent opportunky for personal andprofessinal growth. Quallfled appliants should forward their resumes, In con-fldence, to Sheri Rist, Genetcs Institute, 87 CambridgePark Drive, Cam-bridge, MA 02140. An Equal Opportunity Employer

Genetics Institute

The Medicinal Chemistry Department of Smith Kline & FrenchLaboratories, has excellent career opportunities for persons with expe-rience in protein purification, enzymology, and enzyme kinetics towork in a state-of-the-art research facility near the Philadelphia suburbof Valley Forge. The selected individuals will assist in the design ofmolecules destined to interrupt enzymatic processes; isolate and char-acterize enzymes; analyze interactions between molecules and poten-tial biological targets; and effectively communicate results.The successful candidates will possess:* B.S. in Biochemistry or Bio-organic Chemistry with I to 3 years

laboratory experience.* Minimum 2 years experience in enzyme/protein purification and

characterization.* Experience in the development of specific enzyme assays,

preferably including the use of low levels of radioisotopes.* Experience in modem analytical methods such as HPLC, protein

electrophoresis and chromatography.* Working knowledge of biological reaction mechanisms and enzyme

kinetics is preferred.* Excellent oral and written communications skills are requiredWe offer an excellent compensation, benefits and relocation packageas well as opportunities for personal and professional growth. For con-fidential consideration, please forward your resume and the names ofthree references to Ms. Angela Varrichio, Associate EmploymentAdministrator, V0014, SK&F Laboratories, P.O. Box 1539, King ofPrussia, PA 19406-0939. We are an equal opportunity employer,M/F/H/V.

MOLECULAR BIOLOGISTSSTAFF FELLOW/SENIOR STAFF FELLOW

NATIONAL INSTITUTES OF HEALTHPUBLIC HEALTH SERVICE

Fellowships available for experienced molecular biologists for amegabase DNA sequencing project involving automated DNA

sequence analysis of neurotransmitter receptor genes (PNAS 848296-8300, 1987) and of disease loci of human chromosomes and for

site'directed mutagenesis studies involving adrenergic andmuscarinic cholinergic receptors (JBC 263, 4052-4055, 1988)

Applicants must be U.S. citizens or resident aliensInitial appointment is for two years with extensions

possible up to 7 yearsStarting salary will be commensurate with experience

For staff fellows (less than 3 years postdoctoral experience)$20,000 to $37,997

For senior staff fellows (over 3 years postdoctoral experience)$24,000 to $42,600

For further information and qualifications callJanet Clagett, NINCDS Personnel Office

301-496-6334

Applicants should send their curriculum vitae and namesof three references to

J. Craig Venter, Ph.D., ChiefReceptor Biochemistry and Molecular Biology SectionLaboratory of Molecular and Cellular Neurobiology

National Institute of Neurological & Communicative Disorders &StrokeNIH

Park Building, Room 405Bethesda, Maryland 20892

NIH IS AN EQUAL OPPORTUNITY EMPLOYER

DEPARTMENT HEAD, ENTOMOLOGY

UNIVERSITY OF ARIZONA

The University of Arizona invites applications andnominations for the positon of Head of the Department ofEntomology, College of Agriculture. A scientist with a strongappreciation of and willingness to support both the basic andeconomic phases of entomology is sought to lead thedepartment in research, teaching and extension andstrengthen its international reputation.

The head is expected to take a leadership role in facilitatingstudies of insect science throughout the University viaparticipation in the Center for Insect Science, a newlyestablished pan-collegiate interdisciplinary instruction andresearch program.

Submit curriculum vitae, the names, addresses andtelephone numbers of six references, and a statement ofqualifications and goals to Dr. M. A. Wells, ChairmanEntomology Search Committee, Department of Entomology,Forbes Building, University of Arizona, Tucson, Anzona85721. The committee will begin considering applications onApril 30, 1988, but will accept applications until the positionis filled.

The University of Arizona is an Equal Opportunity/AffirmativeAction Employer. Women and minorities are especiallyencouraged to apply.

BUILDING ANEW LAB?

LET THE SCIENCE FREE PRODUCTINFORMATION SERVICE PUT YOU INTOUCH WITH THE VENDORS WHOSEPRODUCTS YOU WILL NEED.

SIMPLY WRITE US A LETTER STATINGTHE SPECIFICS ABOUT YOUR PROPOSEDLAB AND WE WILL DO THE REST.

WRITE TO:

SCIENCE MAGAZINENEW LAB SERVICE DEPT.1515 BROADWAYNEW YORK, N.Y. 10036

(MT)~ te institute fo nrhicSand (MtIftUn1-(k),,and ie nstitute for Peclie advCedresearche norexstitutesowhic coflectiv* t* l

'|thenewydfOrmed Miles Researc Cte rn Wes ayteappron ||

they CnterfrdnCtiOals a o reserch reSdUrc oAThof West Gerlian and Its subsidary. -Miles ikciI -slocaed n anewly-conlstruce fainy hC sithe.frtosuevralsc fc e tobe built at the West Haven s

gomuIaeae g dnhnp research; the

inn d IAhiseded to the dicoverY Sof newtanget Areas of intereSt include Molecularannrfgdcelar eetlso nek i acptc storYl-ye cellrbioogY.cimmunoloWanipsr tein chernistrY.Thla incli cacinit

SECTIONHEAD--SUPPRE SSOR funCcEeSlmrtlOf and,orhetierywith each othe andT-CARTLAGRE 4BIOLOGY (IAA) roraeCpensin OfeiThe center is'engaged iamjoeansdoidofateswithfandr

The canddate-should have an MD or PhD with at least snding opportunitiesto c

0 years ofpt-doctoral experience. Scientific produc-r credetits ass b belowItivity. the aitryto collaborate. and management skillShould be demonstrable' thro'ugh publications, theachievement, of _sLbstantial' grant Supot and/orgroup leadership. Aninternaetional reputation for work JUNi OR SCIE nTiStDin the areas of osteoaiqhritis ortcartilage degradlation is JUNIOR Sessential, with experience i dru development pre- AI E

MOLECUIARnBILGugB(MTI)CHMITY(II

ferred. The candidatew tewill beexpected to staff thesection aeninitiatl ao asic research prond W ar also sei a st orl- re arch

analpis ofmarnnnalia genes,atal!deels.ignedi kinarpbcor rD,eesearchcloning nd sequnong. aaWsis o expresion. an are alora lane. std oral-leCl ch16

to elucidate new approches to drug. devlopment,Salary is negotiable com,mensurate with qualificationis, iceity xeineinteae fncecai

chemistry and/'or heterogeneous phase reaction is

SECTION HEA-SUPPRESSR dsrbeT-CELL REGULATION (IAA)

Qualifications consistent with the above description are RESEA_RCH ASSOCIATESsought. The candidate's scientific reputation should lie (MDI -and".MTI)in the areas of T-celt suppressor cir-cuits or suppressorfactor biocheMiStry wihknowledge.and interest in the. Appli'cants must have BS or MS degree and at least 1

stud ofautoinmune disease. esp. rheumatoid arthritis. year experience. Proficiency in recombinant DNA tech-niques. tissue cult-ure, protein- chemistry. or assay

SEMNOR.SCI1ENTISTS--i- development is desirable.

MIOLECULAR BIO0LOGY (MTI)Minimum.-requirements are a PhD and 2 years of post- Applicants should be able to function In an Inform'aldocto'ral training.. Experience in mnolecular biology, but cha*nglng research envir'onment wtfth strongmolecular genetics of mammalian cells, or protein bio- acadlimc ties The-pston ofr attractive compen-chemistry is prefierred. Candidates will be expected to satlon. generous bnft,and excteflentopportunfiteswork independently on projerts involving isolation and for esoa rofwith.Rsue shou'ld be forwardedanalysis of mammalian genes at all levels. including to Ae iarh DrtOr0DW. MlsResearch Centercloning and, sequencing, analysis of expression. and 400) Marga Lane,:West Haven. CT 06516.gene transfer.

POSITIONS OPEN

POSIDOCTORAL POSMON to study the enxy-mology ofparvovirus DNA replication and/or mmml-an DNA polymerase ai-primase. Submit curriculum vitacand three lettrs of reference to: Dr. Emanel A. Faust,

D mof Biochemistry, Dalhuie Univeity,Halifax, Nova Scotia, B3H 4H7.

POSTDOCTORAL POSMON: To study aging.Position will involvc research on the molecular basis ofprogeria, a premature aging syndromc. The research willinvolve ccli culture studies of abnormal glycosamino-glycan metabolism and molecular genetic approaches. Abackground in biochemistry and/or molecular biology isdesirable. Position is for 3 years, with a begining salaryof $23,000. Available immediately. Refercnce #517.Send curriculum vitac and threc refcrcnces to:

Dr. W. Ted Brown, ChairmanDepartment ofHuman GeneticsNYS Institute for Basic ResearchIn Developmental Disabilitics

1050 forest Hill RoadStaten Island, NY 10314

POSTDOCTORAL POSMONUNIVERSITY OF CALIFORNIA, IRVINEA position to study the control of gene expression

during morphogenesis in the opportunistic pathogenCaeda alicans. Studies will involve gene doning andtransformation, together with other molecular biologicaltechniques. Excellent training opportunities in moleculargenetics in eukaryotic microbes. Send curriculum vitaeand three letters of reference to:

Paul S. SypherdDepartment ofMicrobiology and Molecular Genetics

College ofMedicincUniversity of California

Irvine, CA 92717An Affirmatie Action/Equal Opportunity Eployfr

POSTDOCTORAL POSMION available in agroup studying mechanism and regulation of eukaryoticprotein synthesis. Projects involve the mechanism ofmRNA entry, regulation of initiation factor activity byphosphorylation, effect of picomaviruses on initiation,cioning of initiation factor genes, and regulation ofiitiation factor levels in vivo. Experience in proteinchemistry, protein biosynthesis or molecular iologydesirable. Salary is competitive and commensurate withexperience. Send curriculum vitae and names of threereferences to: Dr. Robert E. Rhoads, Department ofBiochenistry, University of Kentucy College ofMedicine, LeIngton, KY 40536-0084. An EqulOpportunityLAffirmativeAtion Employr.

POSTDOCTORAL POSMON in neurobiology atWashington University availabk 1 July 1988. Trophicinteractions ofmammalian motor neurons and autonom-ic ganglion cells will be studied utilixing a variety ofneuroanatomical techniques induding intracellular stain-ing. Send curriculum vitae and references to: Dr. Wil-liam Snider, Deparnment of Neurology, Box 8111,Washington University School of Medicne, 660South Euclid, St. Louis, MO 63110.

POSTDOCTORAL POSMON available immedi-ately to study the molecular biology of the renin-angio-tensin system and aspects of kidney physioklgy. NIHfunding. This resea will combine expertise in molecu-lar biology with aspects of cell culture to dissect howangiotensin-converting enxyme production is regulatedby indIvidual tissue types. This work has implications forblood pressure regulation, salt and water reabsorption inthe kidney, and aspects ofdevelopmental biology. Candi-dates should be recent M.D.'s or Ph.D.'s. Experience inmolecular biology desirable. Salary negotiable. Sendcurriculum vitae and references to: Dr. Kcn Bernstein,Room 713 WMB, Dep t of Pathology, EmoryUniversity, Atlanta, GA 30322.Emory Univeity is an Equal Opportunity/Affirmativc

Action Employer.

I566

POSTDOCTORAL POSMON available immedi-ately for studies of epithelial cell biology using biochemi-cal and immunological techniqucs. Emphasis will beplaced on the metabohism of extracellular matrix compo-nents by normal and mutant ocular tissues, both in vivoand in vtro. Send curriculum vitae and the names ofthrec references to: Dr. L Stramm, Dqetment ofOphthalmology, Univcrsity of Pennsylvani 51North 39th Street, Phildelphia, PA 19104.

POSTDOCTORAL POSMON IN MOLECU-IAR BIOLOGY AND BIOCHEMSTRY to isolateand characterize certain amine neurotransmltter recep-tors. Experience with cloning techniques, protein chem-istry, and biochemical pharmacology is desirable Har-vard Medical School appointment. Send r6sumi, summa-ry of research cxperience and three refcrence lters to:Dr. James Nathanson, Neuropharmacokoy R archLaboratory, Massachus General Hospital, Boston,MA 02114. An Equal OpportnitylAffitwuaie ActionExmployfr.

POSTDOCTORAL POSMON IN NEURO-PHARMACOLOGY avaiable for studies on the role ofatriopeptins in the brain and cyc. ence with bio-chemical and physiological pharmacological techniques,including ligand binding, second messengers, proteinphosphorylation, and measurement of fluid dynamics isdesirable. Harvard Medical School appointment. Sendrisume and three references to: Dr. James Nathnson,Neuuphaacolog Research Laboratory, Massa-chusett Geal ospital, Boston, MA 02114. AnEqual OpportuldffinaveAaion Emplyer.

POSIDOCTORAL POSMIION INREPRODUCTIVE ENDOCRINOLOGY

Available immediately to Ph.D. to study hormoneproduction by the fetoplacental unit during baboonpregnancy. Experience with primates not necessary butbackground in endocrinology essential. Send curriculumvitae to:

Geald J. Pepe, Ph.D.Department ofPhysiolog

Eastem Viraia MealScaoolP-.O(. Bow 1980

Norfolk, VA 23501An Equal OpportunitylAffirmativeAction Employer

POSTDOCTORAL POSMONTUMOR VIROIOGY

Available immediately, wc have recently discoveredRNA covalently bound to SV40 TAg and to the onco-gene product p53. The RNAs, the bonding and thepossible significance to oncogenic transformation will bestudied. Stipend in the range $20,000 to $26,000. Sendcurriculum vitae and names of three references to:

Dr. Robert CarrollDepartment of Pathology

New York Univerit MedicaSchool550 First Avenue

New Yorks, NY 10016

POSTDOCTORAL POSMIIONS available imme-diately for studies ofHIV immunochemistry and iunmu-nobiology. Areas of research interests indude develop-ment ot an effective synthetic pptide vaccine (Dr.Gordon Dreesman); idiotyeanti-idiotype network,Sene cloning, immunoslobuln variable reon sequenc-ng, and peptide cemiry (Dr. Ronald C. Kennedy);definition of HIVWB and T cel epitopes, murinc andhuman monocdonal antibodies and human T cell cloning(Dr. Tran C. Chanh); and simian immunodeficiencyvirus (Dr. Jonathan S. Allan). Annual salaries rangefrom $20,500 to $23,920, dependent upon expericcn.Pleasc mail curriculum vitae with names and telephoncnumbers of three references to: Personnel Director,Southwest Foundation for Biomedical Research,P.O. Box 28147, San Antonio, TX 78284. EqualOpporunity EmpkyerMlF.

POSITDOCTORAL POSMON-RESEARCHASSOCIATE Clinical laboratory and research center todevelop new testing procedures in the fields ofoncology,experimental hematology, and immunology. This is adefinite goal-oriented position for 2 years. If successful,then partnership position available. Scnd curriculumvitae and other appropriate records in confidence to: Dr.Michael E. Trig, Molecular Medicne, Inc., 5606Shields Drive, Beheda, MD 20817.

POSIDOCTORAL RESEARCH ASSOCIATEPosition available to study the biochmistry, regula-

tion, and molecular biology ofred blood cell membranesand membrane-skektal protins. Applicants with experi-ence in protein biochemistry, biological membranes,protein kinases and molecular biology (especially site-directed mutagenesis) are encouraged to applyOpportu-nity to join an established group m a wellequipped andactive department. Position availabk immediately. Ahighly competitive salary appropriate to experience willbe offered. Send curriculum vitae and names of threereferences to: Carl M. Cohen, Ph.D., Chief, Divisionof CelLlar and Molecular BioIogy, St. Elizabeth'sHospital, 736 Cambridg Street, Boston,MA 02135.Eqsal Opp0tnity Employer.

UNIVERSITY OF LEICESTERPOSTDOCTORAL RESEARCH ASSOCIATEApplications are invited from candidates with a strong

background in immunology to join a research groupinvestigating the design of novel protein antigens forimmunoprophylaxis and diagnosis of parasitic and bactc-rial diseases. The successful applicant should preferablyhave had 1 to 2 ycars ofpostdoctoral experience and havean interest in protein structure, epitopic domains orimmune responses. He/she will be expected to contributeexertise to the immunological analysis of geneticallyengineered antigens.The appointment (funded by the Wellcome Trust) is

available fom 1 April 1988 for 3 years, and will have astarting salary of up to £12,760 per annum, dependingon qualifications and experience (lA Research Associatescale £9,865 to £15,720 per annum-ffective from 1March 1988).

Further details may be obtained from: Dr. T. R. Hirst(0533)-523431.

Applications, induding a full curriculum vitae, and thenames, addresses, and telephone numbers of two refer-ees, should be sent to: Dr. T. R Hirst, Department ofGenetics, University of Leicester, Lcicester LEI7RH, England.

POSTDOCTORAL RESEARCH ASSOCIATE.Ph.D. in analytical chemistry with 2 years of experiencepre- or postdoctoral in the operation of phase-modula-tion and phase-resolved spectrofluorimetnc inst enta-tion, fluorescence polarization, and inmunochemicaland micellar reagents. Conduct research in the area ofchemical analysis induding fluorescence spectroscopyusing phase-modulation and phase-resolution tedh-niques, studies ofimmunochemical and micellar systems,and the use of microcomputers in conjunction with theexpernments. Forty hours per week. Salary: $25,000 peryear. Apply. Employment Security Commission f16North Mangum Street, Durham, NC 27701 or yourlocal job senrice office. Refer to: Job order #NC7101845, DOT code 090.227-010. If not a U.S.citizen, indicate visa status. Equal Opporunity EmplotrlAffirnate Action.

POSTDOCTORAL RESEARCH ASSOCIATEPOSITION available to study growth factor-oncogeneinteractions and signalling mechanisms involved in cellproliferation and transformation. The research involvesuse of recombinant DNA technology and recombinntretroviruses in eukaryotic tissue-culture systems. Candi-dates must have a Ph.D. with a background whichincludes molecular biology, somatic cell genetics, mam-malian mutagenesis and gene cxpression systems andretrovirology, as well as regulation of genes, immunolo-gy and FACS. Submit resume, research intests, tran-scripts, and names of three references to: Dr. M. J.Wcber, Department of Microbiology, Box 441, Uni-versity ofVinia School ofMedicine (UVA), Chr.lottesvile, VX i908. UVA is an Equa OpportuntyExTloyer.

SCIENCE, VOL. 239

POSITIONS OPEN POSITIONS OPEN

BLOPROCESS

D)EVELOPMENTffmann-La Roche, a prestigious leader in the

production pharmaceuticals,

vitamins and fine chemicals has three oppor-tunities in Bioprocess Development for in-

dividuals with excellent communication skills and the desire towork in a team environment.

FERMENTATIONENGINEER

Your primary responsibilities will include the development offermentation processes, scale-up of conventional and rDNA pro-jects, maintenance/upgrading of state-of-the-art pilot scale fermen-tors, technology transfer, evaluation of new technology and supervi-sion of support personnel. To qualify, you should possess a PhD inChemical/Biochemical Engineering with an appropriate backgroundin Fermentation, or an MS with relevant experience; knowledge ofcomputer hardware and software is preferred. Please efer to Posi-

tion ABD on envelope and resume.

SCIENTISTYou will be responsible for the isolation and purification of recombi-nant proteins on small and pilot scales. To qualify, you must have anMS in Biochemistry plus 7 years of relevant experience, or a BS with10 years of experience. Knowledge of HPLC, FPLC, SDS-PAGE,isoelectric focusing and conventional chromatography is necessary.Please rer to Position BBD on envelope and resume.

ASSOCIATE SCIENTISTWorking on similar projects as the above Scientist, you'll need anMS in Biochemistry plus 3 years, or a BS with 6 years of relevant ex-perience. Plea reW to Position CBD on envelope and resume.

For consideration, please send your resume, indicating salary his-tory/requirements (those without this information will not be ac-knowledged) and position of preference to: Elanor M. Malone,Professional Employment and Staffing Specialist, Hoffmann-La Roche Inc., Nutley, New Jersey 57110 We are an equal oppor-tunity employer

Hoffmann-La RocheWorking Today For A Healthier Tomorrow.

Du Pbnt's Central Research and Development Department has immediate openings for expenenced PhD en-zymologists to develop biocatalytic routes to pharmaceutical intermediates. Positions are available in the follow-ing areas-Mechanistic Enzymology - Requires a strong background in biochemistry, chemistry and kinetic assaydesign, and experience in enzyme inactivation and stabilization.Biocatalysis - Requires a working knowledge of enzyme kinetics, purification/characterization, and ex-perience in process scale-up, enzyme immobilization and catalytic use of enzymes.Enzyme Production- Requires experience identifying and purifying enzymes from novel sources, andthe ability to select and grow microorganisms for enzyme production. Experience in large scale fermentationand cloning in high expression systems is preferred.Successful candidates will become members of an interdisciplinary development team, and must possessdemonstrated creativity and problem-solving abilities. Post-d rlexpenience is desired.At Du Pont you11 find asiuaigsinii niomn namdmrsac aiiylctdna imington, DE. Our Mid-Atlantic location offers a wide range of academic, cultural and recreational activities. Weprovide excellent compensafion, benefits and relocafion assistance. Qualified candidates should send a cur-riculum vitae with three references to Dr. David Anton, c/o Professional Staffing Section, Employee Relations

U.S. Citizenship or Permanent Visa Re uiredAn Equal Opportunity Employer MIF V

Ift us_TtavT OI

POSITIONS OPEN

POSIDOCTORAL POSMONS. Available imme-diately to study altcraons in the synthesis and process-ing of salivary and gastrointminal mucins i cysicfibrosis, gastroointnal diseasc, and alohlism. Candi-dates with experiecc in biosyntdhtic and molecularbiology tecmques, phospholipid metbolism, mcm-brane receptors, and immunochemistry are desirabk.Send rdsum, statement of researc intrsts, and refer-ences to: Dr. Amalia Slniany,DofMedi-ane, Ncw York Medial Colle, Valhal, NY10595.

YALE UNIVERSITYSCHOOL OF MEDICiNE

DEPARTTMENT OFTHERAE!UTIC RADIOLOGY

POSTDOCTORAIRESEAICH ASSOCIATE:Exciting opportunity for Ph.D. withe in cellbiology/protein biochemistry/molecular biology to joinin the establishment of a vascular molecullar biologylaboratory at Yale University Medical SchooL Investig-tions in basic growth regulatory mechanism, biochemis-try and radiobiokgy of blood vessel celis. Academicappointment and compettive salary. Plea send curricu-him vitae to: Dr. EliotM osen, Depart ofTheral,,eutic Radiology, Yale Uniy S ofMeicine, 333 Cedar Street, New Have, CT 06510.

POSTGRADUATE AND FACULTY RE-SEARCH PROGRAM AT THE AGENCY FORTOXIC SUBSTANCES AND DISEASE REGIS-TRY-ATSDR is a new agency of the Public HcalthServicc based in Atlanta created to imlent health-rclated sections of laws that protect the public fromhazardous wastes or cnvironmental spills of haxasubsunces. Immediate openngs are availabl for thosewith experience in toxi ,e idemiology, health odu-cation, and related areas. U.S. ctixeship or PRA statusis required. For more inf aion and applications con-tact (plase indicate iffacultyor po ae): R chPariiaion ProVmAtSDRt, Univriy PrormDivision, Oak Ridge A IdU , P.O.Box 117, Oak Ridge, TN 37831-0117. Telephone:615-576-3190.

POSTDOCTORAL RESEARCH ASSOCIATEposition available immediately in falty ad biocmistry.ackgrnd in arachidonic acid metabolism, prsglan-

din biochc omga-3 fa acidmetabolis andGC/MS analyrsis dairabk. Studies will inhde arachi-donic acid and onmga-3 faty acid metabolism in plate-kts, vascular tissue and monocyts, and their relationshipto dtombosis and adteosclrosis. Send curriculum vitaeand names of three references to: Vitor A. Skrinska,Ph.D., Ckveland Reearch Institute, 2351 East 22ndStreet, Cklveand, OH 44115.

OREGON HIEBALTH SCIENCES UNIVERSITYPOSIDOCTORAL RESEARCH POSMONSAvailabk to study the acions of EGF and TGF in

transmembrane signalling and control of gene cxprcs-sion. Requires combined appLication of recombinantDNA tecniques and bioch cal analysis of secondmessen$rs, including calcium and phospholipids. Ex-pertisnm one of thee areas required. Salary commensu-rate with experience. Pleasc send cumrcuum vitac and thenanxs of dtr refeences to: Dr. Bruce E. Magun, De-

p of£Cdl Bio-okr andAntm, L215,OregonSds Uniei, Portad, OR 97201. An

EqualOppAainExw.

PRODUCT MANAGER-PHYSIOLOGICAL RESEARCH AND

MEDICAL INSTRUMETSExclclnt opportuniy in cstablished company (50

employees) tolaunch new division of PC-basod comput-er automantion products for scientific and medical appli-cations. Explosive growth potentiaL

Successful idate will bc a hih motivated andorganized "doer" with strong writmg and computer

Ph.D. in one of the physiologcal scinces desirable.Stong bagoun in ecnics a plus.No previous excnnce in product manage or

markenag is required. Chicago locationPlease submit r6sum6 and salary history in confidence

to: Box 48, SCIENCE.

The Project Management Depuatment of Smith Kline & French Laboatoriesis seeking a Ph.D. to assit Project Leaders in the design and m ementof drug development strategies and in the identification ofp t mstones and objectives. Primaty responsibilities include ensuring that pro-jects remain on schedule by identifing prblems and detemining optinalsolutions; coordinate and manage the submission of plans, m ions toplns, and progress reports to Project Management maintain awareness ofkey issues for all R&D Projects and their potential impact on avabbility ofR&D resources; ensure Project-related activities and events are adequatelydocumented and archived; and conduct special projects.The successful candidate will have:* Ph.D. in a biomedical science or equivalent trining and experience

required.* At ieast 4 years experience beyond Ph.D. in a biomedical field required.* Experience managing m ulisciplinazy teams is preferred.* Ability to act independently as evidenced by the design and execution of

projects in areas of expertise required.* Proven analical, interpersonal, ieadership and communication skills

required.* Previous project management experience in the pharmaceutical industry

preferred.Smith Kline & French Laboratories, a word leader in pharmaceutical re-search and development is loated in a state-of-the-art research complexnear Valley Forge, PA. We offer an excellent compensation, benefits andrelocation package as well as outstanding opportunities for professionalgrowth and devepmnt. Qualiied tes should send resume to:Marianne J. Shandy, Manager, Personnel Relations, JOOOI, SK&FLaboratories, P.O. Box 1539, King of Pnsia, PA 19406-0939. We arean equal opportunity employer. M/F/H/V. NO PHONE CALLS PLEASE.

PROTOZOOLOGIST/MOLECULAR BIOLO-GIST. Full-time tenure-track faculty position. Assistat/assocate professor, starting 1 Jul1r88or thereafier inDeparmennt ofTropical Modicine. Qualifications: Ph.D.or equivalent in protozoology with specialty in molecularbiy, po exprience, publications. Respon-sibilities icude partipatig i teaching medical proto-xoologyr tO graduate and medical students, teachingcourse in sp , developing competitive research pro-gram, araduate students' reach. Oppor-tunity to participate m ent's oves p .Send curriculum vitae to: Chim , Sarch mmit-tee, De ment of Tropical Mdicine, Tulanc Uni-versity School of Public Health and Tropical Medi-ine, 1501 Canal Street, New Orleans, L 70112.Deadline is 1 May 1988, or until filld Tulan Umniyi an Equal Opporuniyl/Affai* Acaimn Explyr.

RESEARCH ASSISTANT PROFESSOR, Depart-ment ofMedicine, Ph.D. in physioy or pharm ywith postdooral fellowship in physioogyexpenmcnt hyperesion. Knowe dgeof radioim-munoss, chromatography, receptor assays desired.Wl devebop/direct experimen animal laboratory. Sendcuiculum vitae and thee refrences to: John Baner,MD, Prof ofM i, Universityof Missori-Colombia, Combi, MO 65212. An AffirmativeAc-ion/Equal Oppo0tunity Employff.

RESEARCH ASSISTANT/ASSOCIATE PRO-FESSOROF SURGERY. The Departint ofSurgey,University of Health Sc e Chicago MedicalSchool has an opniing for a Ph.D. biochemistor physiol-ogist with expertise m molcular biology to head theSurgical Research Laboratory. Tcnure-track position.The dpartmnt has strong research interests in appliedbiochemistry and molecuar biology. Send curriculumvitae, copies of pertinent publications, sununay of pastand present reseahprojects, and throc personal refcr-ences to: William Schumer, MD., Pfeor andChairman, Dqeartment of Surgey, Unvemrsity ofHealth Scences/he Chkago Medical S&hool, 3333Green Bay Road, North Chicag, IL 60064.

POSTDOCTORAL SCIENTISTDRUG DELIVERY

Amgen is a dynamic leader in the biotechnology industry. Ourleadership in the development of Erythropoietin and otherproducts for human and animal health care has placed usfirmly at the forefront of the industry. Because of our rapidgrowth, we have an immediate opportunity for a Post DoctoralScientist in our Drug Delivery Group.

Qualified applicants must have a Ph.D. in Chemistry orBiochemistry and an interest in fundamental studies ofcontrolled drug delivery. The fields of interest include polymersynhesis and biodegradation, synthetic and biolgical mem-brane transport processes and mechanisms of self-regulateddrug delivery. Post doctoral positions are one year appoint-ments renewable for a second year.

Amgen offers a challenging and rewarding research environ-ment as well as an excellent compensation and benefitspackage. Amg.n is located about an hour northwest of LosAngeles in the scenic Conejo Valley. Qualified candidatesshould send a c.v., including three references, in confidenceto:

Recruitment, Dept. #35AMGEN1900 Oak Terrace LaneThousnd Oaks, CA 91320

- qJOpportnty Empoy

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POSITIONS OPEN POSITIONS OPEN

Research

Professionals

Genentech, Inc., a leader in the field ofbiotechnology, has the following oppor-

tunities available at our South San Fran-cisco headquarters.

Research Assistantsand Postdocs

Research Assistants and Postdocs are

needed in the Endocrine Group to run bio-and immunoassays; an advanced degreein science and two years experience are

prerequisites. A Postdoctoral position isalso available for a scientist devoted to anyof the following areas: cell signaling, lineargrowth, animal modeling, primate parturi-tion, endocrine control of immune func-tion, bone or nutrition.

ScientistsThree Scientist positions are available inthe Endocrine Group in the areas of bone,linear growth and parturition. Demonstra-tion of leadership in the field, and practi-cal experience with relevant assays isessential.

Please send curriculum vitae and three let-ters of reference by April 25, 1988, to: EricMankuta, Human Resources, Genentech,Inc., 460 Point San Bruno Blvd., South SanFrancisco, CA 94080. An equal opportunityemployer.

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Genentech, Inc.(2(S @@ 2( O9 mx

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Senior BiochemistCholesterol Metabolism

The Squibb Institute for Medical Research is recognized interna-tionally as a leader in developing novel therapeutic agents for thetreatment of cardiovascular diseases. We have recently expandedfurther our interest in the cardiovascular areas to includehyperlipidemia and related diseases. Consequently we are seek-ing an experienced biochemist to develop animal systems for thestudy of investigational drugs in cholesterol metabolismdisorders.

Qualified individuals should have a Ph.D. in Biochemistry or arelated discipline and a minimum of one year post doctoral ex-perience in lipid biochemistry. Direct experience with experimen-tal animal models is required.

The highly challenging opportunity demands a creative ap-proach to the study of cholesterol metabolism and a strong in-terest in the development of anti-hypercholesterolemic drugs.Squibb is located in Princeton, NJ, a pleasant semi-rural settingconvenient to both New York City and Philadelphia. In addition toan excellent salary and comprehensive benefits package, we canoffer the opportunity for exceptional scientists to pursuestimulating careers.

For consideration, please submit your curriculum vitae ta TheSquibb Institute for Medical Research, Human ResourcesDepartment 799, P. Box 4000, Princeton, NJ 08543-4000.An equal opportunity employer.

SQUiBBWhere science comes to life.

XOMA Corporation, a leading biotechnology company situated inthe San Francisco Bay Area, is seeking a Postdoctoral Scientistto join an existing research group involved in the design anddevelopment of new cytotoxic molecules for therapeutic use.

XOMA considers postdoctoral studies important in an individual'scareer development and the publication of findings is encouraged.The appointment is for one year, renewable for a second year.The position is available immediately.The successful candidate should have:* A recent Ph.D. in Molecular Biology, Biochemistry, or related

discipline.* A strong biochemical background, with experience in protein

purification and characterization, cultivation of micro-orga-nisms, and recombinant DNA techniques.

* Excellent academic record, strong communication skills and acapacity for independent study.

* Experience in the field of toxin molecular biology is desirable.We offer excellent compensation and benefits. For confidentialconsideration, send your C.V. to:

Director of Human ResourcesXOMA Corporation

EOE 2910 Seventh St., Berkeley, CA 94710El II

M-

I

POSITIONS OPEN

The Dep et of Pathology at the Uniformed Srv-ices Univcrst ofthe Hcakh Sciences is seeking to hire a

HASSISTANT PROFESSOR Thc indi-vidual is to join eaxsting research cffort to study areas ofmolecular genetics of a cancer-pronc family, molecularmechanism of ocllular radiation resistance, and/or theinvolvement of oncogenes in human maligancies. Thesalary range for this position is $25,0 to $34,000depending on background and experiencc. Individials(three or more years of postdoctoral experience) withbackground in molecular genetics, biochemistry, micro-biology, and differentiation are encouraged to apply.Send curriculum vitae, a description of current rsarchactivitics, and the names of three refernces to: CivilianPesnd, Uniomd Scs Uniest of thHealh Sdcencs, 4301 Jones Bridge Road, BcsdMD 20814-4799. Dcadlinc: 1 May 1988.

RESEARCH ASSISTANT PROFESSORSApplications are invitod for a cell neurophysiobgist,

and a mokcular neurobiologist to study (i) the suctmeand function of cerebeliar auditory area, and (ii) sensorytransduction in acoustic reccptor cells in the auditoryperiphery. Projccts are conducted in a multidisciplinarysng within the Division of Structural and SystemsBiology and the Division of Molecular Biolgy andBiochemistry. Practical experience in one or more of thefollowing areas are desirabk, (i) electrophysiolog ofvision, (ii) intracellular recording and smna,(in) insitu hybridization, (iv) patch clampn ofdsssociatdcels, (v) protcin chemistry, (vi) molea r genciics.Duties will indude light team-teaching. Send curriulumvitae and names of three references to: C. Hung,School of Basic Lifc Sciences, 109 BSB, Universty ofMissouri-Kansas City, Kansas City, MO 64 10-2499. Deadline is 15 May 1988 or until positions arefilled. EqlOWpportunxty Employer.

RESEARCH ASSOCIATE position availablc forwork on tissue specificity and physiological control ofrespiratory chain enzymes. Experience in mitochondrialresearch and/or protcin chmistry essential. Ph.D. re-quirod. Salary according to NIH guideincs. Send r6sumcto: Dr. R Cyaldi,D t ofBiology, Universi-tyof Oregon, Eugene, OR 97403. Closing date: 22April 1988. An Equal OprtunxyL4ffirnae AaionExployer.

RESEARCH ASSOCIATEThe Center for Laser and Applied Technology, Char-

lottc Memorial Hospital and Medical Centcr invitcsaplications for a ful-time research associate positiKn.c position will involvc research in cardiovascular apli-cations of lasers. Individuals appl should hav previ-ous cxperiencen small animai su cardiaccatheterization, cardiopulmonary bypass p sion ofcanines, and the use oflascrs. A 2- or 4year degree in arelated field is also rcquired.

Intcrested applicants should submit curriculum vitaeand letters of recommcndation by 15 April 1988 to:

George TatiHeineman MeicResarch Laboratory

P.O. Box 32861Charlotte, NC 28232

Equal Oppotunity Employer

RESEARCH ASSOCIATE to study mechanisms ofcell-mediated immune responscs toHIV as part ofalargeepidemiologic investigation of HIV infection in homo-sexual mcn. Faculty nontenure-track position, 2 to 3years duration, availabk 1 June 1988. Ph.D. required.Salary $22,000 per year. Send curriulum vitae andnames of three references to: Dr. Charles Rinakdo,Department of Infectious Diass andMibiA417 Crabtre Hall, Universit of Pittsbur Gra-uate School of Public Health, Pttsbugh, PA 15261.AnAfftaieAiolEqual Opp rtntE r.

RESEARCH POSMONWe are cstablishing a basic cerebrovascular research

laboratory for the study of ncural ischemia or cerebralblood flow. Ncwly constructed space, equipment sup-port and a competitive salary arc availabbk. Funded orexperienced M.D.'s or Ph.D.'s are desirabk. Three refer-ences and curriculum vitae are necessary. Contact: Dr.John B. Selhorst,P and Chairman, Dq at-malt of NeurolgyW, St. Louis Univeri, 3660 tmaAvenue, St. Louis, MO 63110.

POSITIONS OPEN

RESEARCH ASSOCIATEMOLECULAR BIOLOGY/BIOCHEMISTRYThe Deparmet of Padtology, College of Vetrinary

Medicine, Cornell University, has a position for a molec-ular bioloist to collaborate in the study ofthepatlogen-esis ofX-inked (Duchenne) musculardyshy, usmg aunique model sy . Competence in molecular ctechniques uird. E c in protein biochmisability to work independently prefrred Salar ommen-surate with eperience: $20,000 to $25,000 pr year.Available immediately. Send ktter of application, risu-mi, treeletuers of r eon to:Barry J. Coo-per,Dqmrtt ofPatholgy,CollgeofterinayMedic;ne Cornel Univ , Ithaca, NY 14853-

6401. Tepone: 607-253-3350. Cou Uniy isan Equal Op / Aciion Empyer/Edc-tar.

RESEARCH ASSOCIATEPh.D. in biochemistry, availabk immediately. Experi-

ence in molecular bioogy of membrane protens. Salary$18,000 to $24,000. Send risumn and three refencesto: Dr. 0. P. BahI,Dep t of Biloilc en,SUNY, Cooke Hall, Bufl, NY 1426. SUNY i anAjfinwtiveAaionlEqul Opporuity Employer.

RESEARCH INDIVIDUAL for Deparunent ofAnesthesiology. Must have doctorate in physiology orpharmacology. Experience related to anesthsia researchp . Midwest college town. Contact: G. W. N.EBes Jr., M.D, Proeso and Chairmn,s Depart-ment of A , University o MissouriHealth Sciens Center, Columbia, MO 65212.

RESEARCH SCIENTIST-Ph.D. (dcemisty, bio-dcemistry, or pharmacology) sought to organize andOperate the biocheical and pharmacolkical laboratoryof the Department of Anesthesiology. Highly collabora-tive individual needed with good supervlsory skills.Knowledge of and experience with assays for musderelaxants, narcotics, homnes (especially caechol-amines), substates and nitrogen balance. Experiencewith HPLC, TLC, GC, and RIA. Candidate's area ofresearch and publications would be in pharmacokinetic,pharmacodynamics or muscle relaxants and narcotics,substrates and hormonal responses to surgical stress andrelated areas. Apply with curriculum vitae to: Dr. Rich-ard Matte, D ent of Anest igy Cohim-bis Universi of Physicns S ,P& S Box 46, New York, NY 10032.

RESEAARCH SCIENTIST/ELECIRONMICRO-PROBE. Department of Mineral Sciences, AmericanMuseum of Natural History invites applications for aCuratorial Fellow. Responsibilities incde sarch us-ing as a prmary tool the Deprmt's ninc-channel(+EDS) SEMQ the day-to-day operation and mainte-nance of the inst t (wit the hep of a servicecontract), the insuction of users and looking to thelong-term development of the laboratory. The applicantis expeted to have substantial research withthe electron probe and be willing to 7crelop jointprojects with members of the Department and bcalgeologic community. Ph.D. in mineralogy, petrology ora materials scencerelated field is rquired at timc ofappointment. The position, fully fundca by the Museum,is non-tenured and is immediately availabk.The Dermet consist of four curators, one post-

doctoral fellow and several graduate students reprcsent-ing the ficeds of mineralogy, petrology, volcanology,meteoritics, and economic geology. Close ties are man-tained with Lamont-Doherty Geological Observatoryboth at the staff level and through Museum-supportedfellowships for gradua students. The D tmaintains single crystal and powder x-ray diracometers, petrogaphic microscopes, heatg-fzingstage, thin section and polishing equipment and a chem-istry lab and has one ofthe largest mineral and mectoritecoLlections in North America.Send curriculum vitae and names ofthree references by

15 May 1988 to: Dr. Edmond A. Mathez, AssistantCurator, Department ofMineal Sdcencs (S), Ameri-can Museum of Natural History, 79th Street atCentral Park West, New York, N 10024. An EquOpponity Employer.

1570

POSITIONS OPEN

RENSEARCH ASSOCIATE in reproductive endocri-nology: Immediate opening available for a Ph.D. scien-tist to work in a multidiscplinary group investgangmoecularmechani(s) ofgonadotrpin and eicosanoidaction in roductive tissus. Some previous experiencein subcellular factiona o pufion,ion, en-zyme assays, RNA synthesis, extraction and hybridiza-mon are required. Minimum salr, $17,000 per year. If

interested contact: Dr. Ch.V. ,tofObstri/Gynecoky, 438 MDR Univer-sity f isvill ouisvile, 40292, wi curricu-him vitac and arrange to send dtree letters ofrecomm-dation.

SCENTISrSMatritech Inc., a recently formed biotecnology com-

pany based in the Boston, Massachusett, area, haspositions availabk for Scientists to develop innovativeproducts based on molcular cell biology. Candidatesshould have a Ph.D. and a further 3 to 6 years ofexperience in biochemistry, immunocheniistry, or molec-ular biology, preferably in the area of oncology. Expcri-ence inmnagng other scientists and technicdans in anindustial envionment would be an asset.

Significant opportunities exist for individuals to makea major contribution to this start-up venture and berewarded accordingiy. Miarieh it an Equl O uEmployfr. Send resume to: Dr. Graham P. IMatritech Inc., P.O. Box 895, Cambridg MA02142.

The Environmental Defense Fund is seekg appli-cants for the position of STAFF SCIENTIST in itsNew York City officc. Applicants must have a graduatedecgre in the area of the physical or biological sciencesrelevant to the cnvironment or in an applied science suchas energy studies. Rcsearch ence and good writingsells required. The position provides the opportunity toundertke sentific research and apply the results opublic policy issues.

Please sendrmi to:Georgia Pease

Environmental Defens Fund257 Park Avenue South, 16th floor

New York, NY 10010

The Dcpartment of Organismic and EvolutionaryBiology ofHarvard University invites application for aTENURED POSITION in the field ofmolecular plantsystematics. Starting date to be negotiated. Applicantsshould have demonstrated excellence in research and astrong commitment to teaching at the graduate andundergraduate levels. The closing date for applications is25 April 1988. Please send curriculum vitae, statemnt ofreseah interests, and three letters of recommendationto: P. F. Stevens, Harvard University Herbaria, 22Divinity Avue, Cambrid, MA 02138. HariwdUniwnt*y is anAOiiActionEq O ty Em-Ployer.

TOXICOLOGIST-PUBLIC INTERESTPosition with a national consumer advocacy orgaiua-

tion. Evaluate research on food additives, pestCdeS, andbacteia; hep prepare regulatory peiitions; advise con-sumers and joumalists. Advanced degree, writing skills,and interest in consumer advocacy required. Salary:$30,000 to $40,000. Resumi, popular writng sample,and salary history to: Center for Sicnce in the PublicInterst-DB, 1501 16th Street, NW, Washingtn,DC 20036.

VIROLOGISTWe're a major producer of viral diagnosdc products

located in suburban Washingtn, D.C. Our expandingactivities create achllng opportunity for animdivid-ual with a Ph.D. in virolgy, cell bioloy, immunolgyor equivalent. Requires 2 to 4 years of idustial expen-ence in production troubleshooing, and immunoassaydevelopment. Competitive salary and benefits. Pleaseforward resum- with availability, salary history, andrequirements to:

Peronn_ De t-ASBiotech Reearch aborat Inc.

1600 East Gude DriveRockville, MD 20850

Equal Opporunity/ffinnativ Actin Employer

SCIENCE, VOL. 239

ResearchPmefessionals

Genentech, Inc., a leader in the field of biotechnology,has the following opportunities available at our SouthSan Francisco headquarters.

ScientistProtein Purification &

CharacterizationWe are seeking a highly motivated and innovativeScientist with experience in the purification and charac-terization of proteins. This Scientist will join a multi-disciplinary team of biochemists and biochemicalengineers developing methods to purify and characterizerecombinant proteins to be used as human pharmaceuti-cals. The individual will focus on rapid protein purifica-tion and characterization in conjunction with research.

The successful candidate will have a Ph.D. in Biochem-istry with at least 2 years postgraduate experience ineither academia or industry with a demonstrated recordof accomplishment. Knowledge of HPLC, FPLC, affinityand other protein purification/analysis techniques isessential.

ResearchAssistn/ssocit

We are also seeking a Research Assistant/Associate towork on cDNA cloning and the expression/functionalanalysis of polypeptides. You will also be involved inmembrane signal transduction. This opportunity requiresa BSMS in Molecular Biology, Cell Biology or equiva-lent with at least 2 yeanl experience in molecular clon-ing techniques. Cell culture experience is desirable.

Genentech, Inc. offers an excellent salary and benefitspackage coupled with the opportunity to make a signifi-cant contribution to our organization. For the Scientistposition, please send resume to: Joyce Goulden, HumanResources Dept. 0642, Genentech, Inc., 460 Point SanBruno Blvd., South San Francisco, CA 94080. For theAssistant/Associate position, please send resume to EricMankuta, Human Resources Dept. 1413 at the sameaddress. An equal opportunity employer.

Genentech, Inc.3Nf&Oh on AN EQUAL OPPORTUNITY/AFFIRMATIVE ACTION

EMPLOYER M/F/H

Senior Scientist/Research Assistants

Crop Genetics Intemational, a growing agriculturalbiotechnology company in suburban Baltimore/Washington, has openings in their microbial insecticidedivision. The scientfsts will be part of a multi-discipli-nary team developing novel microbial technologies for"in planta" production of agricultural biochemicals.

SENIOR SCIENTIST requirements are a Ph.D. inBacterial Physiology/Genetics or Biochemistry withexperience in the regulation of gene expression usingrecombinant DNA technology. Training and/or exper-ence in protein structure/function is desirable.

RESEARCH ASSISTANT requirements are a BS orMS in the biological or chemical sciences. Individualswith research experience using recombinant DNAtechniques or protein isolation and characterization(including 2-Dimensional gel electrophoresis and west-ern blotfing) preferred.To apply forward a curriculum vitae in confidence and

the names of three professional references to:

I\ X Dept. Ml

Crop Genetics International7170 Standard DriveHanover, MD 21076An equal opportunity employer.

PROTEIN CHEMISTThe Worcester Foundation is seeking an experi-

enced protein chemist to be the primary operator of aProtein Chemistry Facility now being established. Thiscore facility will be equipped to provide protein se-quencing, peptide synthesis, amino acid analysis andpeptide mapping services to our faculty. The positionoffers the opportunity to contribute to a diverse set ofprojects studying protein structure and function, in-cluding cytoskeletal proteins, receptors, signal trans-duction proteins, mammalian pheromones and severalenzyme systems and proteins found in the nervous andmale reproductive systems. Applicants should haveextensive protein chemistry experience and some famil-iarity with a gas-phase sequencer and peptide synthe-sizer. Salary and level of appointment of this non-faculty position will be commensurate with experience.The Worcester Foundation is a non-profit, basic re-search institute located on a 100 acre wooded campus40 miles west of Boston. Send curriculum vitae, astatement of career objective and three letters ofreference to Protein Chemist, do Personnel Office,Worcester Foundation for Experimental Biology,222 Maple Avenue, Shrewsbury, MA 01545 USA.

I

r

MicroProbeCorporationDNA Probes

Diagnostics andTherapeutics

MicroProbe, a DNA-probe companyhaving strong emphasis on nucleic acidchemistry, has immediate openings forSenior Scientists and ResearchAssociates in:

Molecular Biology: Cloning, sequen-cing, DNA hybridization and non-isotopic signal development.

Chemistry: Synthetic organic chem-istry related to nucleic acids, bio-organicor medicinal chemistry.

Product Development: Assay designand optimization for viral and microbialdiagnostic products.

Senior Scientists will have a Ph.D. pluspost-doctoral training. ResearchAssociates will have a B.S. with researchexperience or an M.S..

MicroProbe is located in suburban Seat-tle and offers a stimulating research &development environment, a com-petitive salary and benefits package,plus an equity position.

Submit resume in confidence to:

MlcroProbe Corporation1725 220th Street SE, No. 104

Bothell, WA 98021

D 1

ChairpersonDepartment ofFood ScienceII

The University of Delaware is seeking adynamic scholar who will provide leader-ship in building research and academicstrength in its Department of FoodScience, College of Human Resources.The Department is young, multidisci-plinary, and with the infusion of addi-tional human and financial resources,has the potential for national pro-minence Their ideal geographic locationhas resulted in collaborative arrange-ments with the many food and chemicalcompanies and research agencies in theregion: there is strong potential for fur-ther expansion. Earned doctorate in foodscience or closely related field, demon-strated achievement in basic and appliedresearch, and research grant administra-tion and teaching. Demonstrated effec-tive management and communicationskills. Applications andlor nominationsincluding the names of 3 referencesshould be forwarded by June 1, 19U8to: Dr. Norman E Collins, Chairperson,Search Committe, 058 Townsnd Hall,University of Delaware, Newark, DE197174303.The University of Delaware is an Affirmative

Action/Equal Opportunity Employer.

I

NATIONWIDE OPENINGSPHARMACEUTICAL R & D

Associate Director Regulatory Affairs IND's,NDA's FDA experience, Ph.D. Pref. Phase I-IVexperience 5-10 years ....... 70K + BonusManager-Compliance 2 positions inGMP/GLP, Ethical Drugs, GCP. 40K + BonusDirector of Manufacturing/Packaging, SolidDosage and Liquids, B.S., M.S., Phar. +MBA .................. 85K + BonusToxicokinetisist Ph.D .............. 45K +CRA's - RN, MS, Ph.D., Various levels 30-50KSolid Dosage Form Development, Sr. Scien-tist-Ph.D. Pharm. 2 + years ...... 40-50KBio-Technology-DNA R & D, Bench to GroupLeader. Cell and Molecular Biology. Ph.D.only .................. 50K + BonusDrug Delivery Development, 0-5 years, Ph.D.,Industrial Experience or Post-Doc. Pro-tein/Small Molecule Background. .. . 45K +Product Manager (Prelaunch Experience) NewPharmaceutical Products (Cardiovascular)

50K + BonusMarket Manager Sales oriented, Forcastingand Projections, create sales aids for productsto HMO and Hospitals........ 50K + Bonus

Employer paid fee- call or write:Paul Amrein

CENTRAL CLEARING, INC.10031 W. Roosevelt RoadWestchester, IL 60153

(312) 450-2660

RESEARCH SCIENTISTSAthena Neurosciences, Inc., located in the San Francisco Bay Area, is abiotechnology-based company committed to the discovery and development of newproducts to diagnose and treat diseases of the nervous system. Our researchfocuses on Alzheimer's disease and the delivery of drugs to the brain. The followingscientific positions are currently available:

Pharmacologist-A position is available at the Ph.D. level for a pharmacologist withproven experience in drug development to aggressively direct preclinical studies onseveral promising lead compounds. Responsibilities will include directing thepharmacology/physiology unit and participating as an integral member of the drugdiscovery/modification team. The optimal candidate will be a neuropharmacologistwith two to four years of experience in the pharmaceutical industry.

Enzymologist-One position is available at the Ph.D. level for an individual withproven experience in protease enzymology and with interest in both proteinpurification and enzyme kinetics.

Molecular Biologist-One individual is sought at the M.S./B.S. level who isexperienced in DNA sequencing, cDNA/genomic cloning and/or mammaliancell expression.

Athena Neurosciences is committed to scientific excellence and offers an excitingprofessional environment in addition to competitive salaries, benefits and equityparticipation. Please send curriculum vitae to: Athena Neurosciences, Inc., 957-PIndustrial Road, San Carlos, CA 94070.An equal opportunity employer.

IWHEflPi Athena Neurosciences, Inc.

ManagerBioanalyticalChemistries

Molecular Devices Corporationhas developed a highly-sensitive,novel silicon-based chemicalsensor, which can provide on-siteanalysis and will be used forinnovative applications inbioanalysis.We are seeking a strong tech-nical leader to direct the devel-opment of new bioanalyticalchemistries from concept throughto feasibility. Qualified candidatesmust have a PhD in Chemistry orBiochemistry, and 5 years techni-cal experience in R&D within thebiotech or diagnostic industry.To find out more, see ourdescription of sensor technologyin Nature, Vol. 329, page 565, orsend your resume to MolecularDevices Corporation, 3180 PorterDrive, Palo Alto, CA 94304. EOE.

9

National Institutes of HealthU.S. Public Health ServiceNATIONAL INSTITUTE OFNEUROLOGICAL ANDCOMMUNICATIVE

DISORDERS AND STROKEStaff/Senior Staff

FellowshipThe Surgical Neurology Branch (SNB),Division of Intramural Research (DIR),National Institute of Neurological andCommunicative Disorders and Stroke(NINCDS), National Institutes ofHealth (NIH), Public Health Service(PHS), announces a Staff Fellowshipopening. This postdoctoral tenure-track fellowship is available to studythe cell biology, endocrinology ormolecular biology of the pituitarygland and pituitary tumors. The ap-pointee will be expected to initiate in-dependent research. SNB seeks ascientist who can relate laboratory ef-forts to clinical pituitary problems andwho is eager to interact with an activepituiatry surgery program.For the NIH Staff Fellowship Program,candidates must be U.S. citizens orresident aliens within four (4) years ofreceiving U.S. citizenship, and musteither have been awarded their doc-toral degree in fields closely related tothe position, or have been certified by auniversity as meeting all the re-quirements leading to such a doc-torate. Candidates with less than 3years of professional level post-doctoral research experience may beconsidered for entrance into the pro-gram as Staff Fellows (SF). SeniorStaff Fellowships (SSF) may be con-sidered for those having 3 to 7 years ofprofessional level post-doctoralresearch experience. The salary rangesfor the SF Program are $20,000pa(PhD's)/$24,688pa (MD's) to $35,491pa(PhD's)/$37,997pa (MD's). The salaryranges for the SSF Program are$24,000pa (PhD's)/$28,000pa (MD's) to$42,600pa (PhD's)/$49,266pa (MD's).Starting salary is commensurate withexperience. The initial appointment isfor two (2) years with additional exten-sions of up to five (5) years possible,for a total of seven (7) years in the pro-gram.Further position information andqualifications requirements may be ob-tained by calling Clifford Schein on(301) 496-6334. The position is locatedin Bethesda, Maryland. Interested can-didates should send a curriculumvitae, a brief statement of research in-terests and the names of three (3)references to:

Dr. Edward H. OldfieldChief, Surgical Neurology Branch

DIR, NINCDSBuilding 10, Room 5D37National Institutes of Health9000 Rockville PikeBethesda, MD 20892Telephone: (301) 496-5728

NIH IS AN EQUAL OPPORTUNITY EMPLOYER

Opportunities for PhDs in

CARDIOVASCULARRESEARCH* Cardiovascular Pharmacologist* Biochemical Pharmacologist

We're Ortho Pharmaceutical Corporation, part ofJohnson & Johnson, the most broadly based health care com-pany in the world.

We have 2 immediate openings in our Division of Phar-macology for a biochemical pharmacologist and a car-diovascular pharmacologist. The biochemical phar-macologist will have a solid foundation in cardiovascularpharmacology and demonstrated capabilities in studyingdrug action at the biochemicallmolecular level usingradioreceptor, radioimmunoassay, enzymological and cellculture techniques. The cardiovascular pharmacologist willhave a strong background in the measurement ofhemodynamic parameters in whole animals, develop modelsof ischemia and infarction and possess the ability to assessregional myocardial blood flow distribution.

These individuals, with approximately 2-5 years of postdoc-toral experience, will be part of a multi-disciplinary teamtargeted to the discovery of drugs for the treatment of a varietyof cardiovascular disorders including myocardial infarctionand coronary artery disease. These senior scientists will beexpected to:

* participate actively in our ongoing drug discovery efforts;* establish an independent drug discovery program;* interact with scientists in a variety of disciplines includingmedicinal chemistry;

* conduct drug evaluation studies and participate in thedecision-making process of recommending compounds fordevelopment; and

* possess excellent oral and written communication skills.

In addition to a fully competitive compensation and benefitsprogram, we offer a stimulating environment in which to growand be recognized accordingly. If you are willing to acceptthe challenge and meet the above qualifications, pleasesend your resume including salary history and requirements,to: Mr. Frank Folio, Dept. 19, Ortho PharmaceuticalCorporation, P.O. Box 300, Raritan, NJ 08869-0602.

An equal opportunity employer, M/F.

I

ORTHO PHARMACEUTICALCORPORATION

A Company

A LOT MORE THAN You THINK.

ORTHO

mp-

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=a

COURSE

OXYGEN RADICALSAspen, Coiorado

16 to 20 August 1988Sixth in a senpes ofscintific ng or-

tan! aspects of basic and dlinical senc liconcentratedreview and discussion of the contribution of oxidants tovarious diseases. Emphasis on recenty discovered mecha-nisms involved in lung injury and ischemia-reperfusiondisorders aickting heart, kidne and other organs. Ofinterest to basic and clinkal scentists. Casual dress.Inquiries to: Dr. Jobn Repine, 303-270-8633, or to:Office C d ,Uv ofCoo-rado School of Medicin 4200 East 9 Avenue,Denver, CO 80262. Telephone: 303-270-5195.

GRADUATE TMININGGRADUATE TRANINGIN NEUROSCIENCE

The Departn=t of Physiology and Biophysics atHamnemann University has graduate stipends availableto support students pursuing a Ph.D. degree in physiolo-gy beginning in Septenber 1988.The dartm has particular rarch stegths in

neurophysiology, ne harmacogy, and neuroanato-my. Speific areas include: extrahypothalaic actions ofsex steroids (Sheryl S. Smith), besal pnglia function(Fay Scider), ccrcbral cortex function, neural net-work simulaions and alcohol (John L Chapin), andcentral monoamine systems, epilpsy and drugs of abusc(Barry D. Waterhoeu).The program is open to students with a B.S. or M.D.

degree. Further inmation and application forms areavailable from: Dr. Joseph ToOrs, DPhysiolgy and B , hiS. 409,Univ ity, Broad and Ve, Phladephi, PA19102-1192. AffirmativeAcion Exployer.

WORKSHOPS

TRAmININ PRORAM

POSTDOCTORAL FELLOWSHIPMENTAL ETARDATION ANDDEVELOPMENTAL DISORDERS

An immeiat opcning is availabk at the EuniceKennedy Shriver Cnterr for a Ph.D or M.D. in aninterdscplinary nrscce training progam support-ed by NIHD.T is particularly diected to areasOfrearch levant othe biological basis, treatment, andprevention of mental retardation and other devebpmen-tal dikorders. The proBam emphasizes devdopmentalneurobiology and its ance and inch theareas ofnuro mistry,n and cell bioloy.Specific areas of intcrest incude cel surface glycoconju-gates (McChuer,Jungal Schwarting, Yamamoto)molcuxlar neurogenetics (Breakedleld), the role of lso-somes in cellular d cs (Kolodny), myelin strutureand function (Lees, Jungalwala), molecular biolgy ofbrain cytoskeleo (Fischer) and neuonoci6okMyand sexual differentiation (Fox). The Center is loated nsuburban Boston and has affiliations with MassachusetsGencral Hospital and Harvard Medical School. U.S.citiznship orp an residence required. For furithcrinfurnation contact: Dr.M jorie es, E. L ShrvCanter, Biochemit Deprment, 200 TrapeloRad, Waklham, MA 02254. Telpone: 617-642-0129.

FELLOWSHIPS

POSTDOCTORAL FELLOWSHIPS available inneurobiological and behavioral development. The Uni-versity of Virginia announces a new NICHD multi-diciplinary program.Nichola J. Len, Synaptic DevelopmentMLD, Pi.D. (Program Director)

Oswald Steward, NeuroplasticityPhD. (Co-Directr)

James Bennett, NeuropharmacologyM.D, Ph.D.

Bennett Bertenthal Vision DevelopmentPh.D.

Peter Brunjes, Ph.D. Sensory DevelopmentPaul Gold, Ph.D. Neuroendocrine Regulation

of MemoryIrving Go mn, Genetic Mental IllnessPhD.

John Hackett, Ph.D. Synaptic TransmissionDavid Hill, Ph.D. Sensory DevelopmentWilliam Levy, Ph.D. Synaptic ModificationErc t MD., Physiology of EpilepsyPh.D.

Richard McCarthy, Autonomic DevelopmentPh.D.

DeForest Mclln, Jr., Neuromnusular DevelopmentPh.D.

Sally Moody, Ph.D. Neuronal and AxonalDevelopment

Lionel Rcbhun, Ph.D. Cytoskeltal DevelopmentEmilie Rissman, Behavioral EndocinologyPh.D.

Sandra Scarr, Ph.D. Developmental PsychologyJeremy Tuttc, Ph.D. Tropic[nteracionsG. Frederick Wooten, NeuophannacologyM.D.Candidates should have a Ph.D. or M.D. degree.

United States citizenship or permanent residency re-9uired. Plcasend curriculum vitae, a one-page descrip-tnon of research interests, and a list of three referes toone or morc preceptor and a copy to the programdirector: Box 290, Utniversity ofVi Charlottes-ville, VA 22908.

SCIENCE FELLOWSHIPS: Applications being ac-cepted for full-time (6- to 12-month) Science Feffow-slups in Medical Sacnce and Technolgy. Unique opportunity for study and writing in areas of: AdolescetHcalth, AIDS, Drug and Alohol Abuse, BiomedicalRescarch, Pharmaceutical Dcvelopment, Nutrition andPersonal Hcalt, Medical Nomendantre, TechnologyAssessment, Scienc Educaton and Mental Health. Musthave research cxpcnence, doc ted wrting sill andthe ability to work independently. Prorated stipend of$30,000 per year. Please send curriculum vitae and non-returnable samples offirst-authored artick(s) to: ScenceFell wsh -001-HBEE AniArican Medica Associa-

Stret, Chiago, IL 60610.

1574

FELLOWSHIPS

FELLOWSEaPS INRBPRODUCTIVE BIOLOGY

NORTHWESTERN UNIVERSITYPostdoctoral and prdoctoral fellowships are available

in reproductive biology for outanding students. Adivcrse but cohesive program offers rarch in thebiochemical, ccllular, jhysiological, and behavioral as-pects of reproduction. articipating faculty indude: Er-win Goldberg (Immunochemistry and reproductive bio-chemistry); Mary Hun ker-Dunn (Ovarian proteinkinase; adenylyl cydasc); William Kkin (Receptors;CNS diflirentiation); Jon Levine (Neuroenocrino-logy); Kely Mayo (Genc rgulation in the maunmalianneuroendocrine system); Neena Schwartz (Gonadal-pituitary endocrinoogy); Joseph Takahashi (Circadianrhythms and photorece.ption) and Fred Turck (Photo-periodism and biological rhythms). Send curriculumvitae and names of three referenes to: Dr. Neena B.Schwartz, Deparmet ofNeurobiolog andPhl-

gY, Northwesn University, 2153 Srid od,Evanston, IL 60201.

An Equal Opporuity EmpoyerPOSTDOCTRAL FELLOWSHIP

POSMONPosition available immediately for biophysical studies

ofmembrane fusion medanisms and membrane permea-bilizanon. Background in free-frace ectron micros-copy, membrane isolation, conjugation of fluorescentmarkers to carricr probes, membrane biochemistry, elec-trophysiology helpful. Scnd curriculum vitae and list of

rences to:Dr. Artbur E. Sowers

Position G119American Red Cross Laboratorics

15601 Crabbs Branch WayRockvile, MD 20855

An Equa Opportuxity EmplyerMlFIVIHPOSTDOCTORAL FELLOWSHIPS

Two postdoctoral positions availabk on 1 June 1988.One position will be mlaboratory studying epitheial cellpolarity and membrane sortnt- will involveanalysis of targeng inepithemal cells transected withgenes encoding ion pump proteins-experience in mo-recular biology is desirabe. Second position will be inlaboratory studying single-ion channels in epithelial cellmembranes of the kidney using patch-clamp methods-experience in membrane physiology desirable. Positionsare funded by deamtal NIH training grant. Appli-cants must be U.S. ctizen or permanent resident. Minor-itinidua warecouragedto apply. Scnd cuniculumvitae with names of references to:

Emile L. B ep, MD.Chairman, tmet of Celkalar and

Molecular PhysiologYak Univer School of Medicine

P.O. Box 3333New Haven, CT 06510

rYa Unimty is an Affimtwe AcaionlEqual Opp0 xity Employer.

MARKETPLACE

I $10.00 a base for the first 15 bases, $7.50 foreach additionl base. For gel purification,

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Research Genetics ICircle No. 110 on Readers' Service Card

SCIENCE, VOL. 239

WORKSHOP ONCONTROL OF CELLPROLIFERATION

IN SENESCENT CELLS12 to 13 A 1988

Montr,4 ,pcbec, CanadaORGANIZERS:

Huber Warner (NIA/NIBethed Maryan)

Eugenia Wang (The Blomfield Centre forResearch in Aging, LDI/JGH/McGill

University, Montl, Canada)The workshop is a sateilite meetng of the

Fourth Interational Congress of Cell Biology,Montreal, Canada. The meeting will fcuson theMteractions among major areas of interest instudying what and how the molecular mecha-nisms operate to teninate cel proliferation atthe end of cells' in vitro life span. The workshopwill feature invited lcts, pklna roundtablediscussions and poster tations. Inter-change aLng atndees is anticipated to kad tonew appes for rsearch in the biologicalsciences of cellular aging.

Applications: Ihe deadlinc for application is15 uime 1988. The totl number ofpartcipantswill be limited to 100. The registration fee forregular participants is US$50, and US$25 forstudents (mae check payable to The BloomfieldCentre for Research in Aging). The reationfee covcrs the lunchcs and the workshop reception but does not cover the cost of accommoda-tion nor the daily transort to and from themeeting site. For a tion foums and otherinfurmation, contact: Dr. Huber Warner,Building 31C, Room 5C21, NIA, NI, Be-thesda, MD 20895. Telephone: 301-496-6402.

For further inumation, contact: Dr. HuberWarner, Telpone: 301-496-6402 or Dr.Eugenia Wang, Telepone: 514-340-8260

Euddb:National Insitute on AigNIH, and The Boomfield Centre furR cin Aging(Lady Davis Institut/GH/McGill Uni-versity.

COLLECTED PERSPECTIVES MNCANCER RESEARCH: 1 -1987

Cwner Research announces the atest compilation of articlesfrom its acclimed "Perspectives" series. Oncogenes, retrovir-uses, growth factors, natural killer cells and breast cancertrabnent are among topics examined by leading cancer au-thoriis. Order copies from Sub $cd"nFumll" t

averl salPr,Inc. P.0 Bu3mors,-22a mufnc (payable in US currency), $9copy(S11 outside US).

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