Officia! Journal of International Society of Cosmetic Dermatology

INTEANATIONAL EDIEMME

Volume 9 - Number 2 Aprii / June 1991

ISSN 0392-8543 Sped . abb. post. IV0 70

Per Campioni Medici e Documentazione Scientifica: Mavì Sud s.r.l.. Viale dell'Industria, 1 - 04011 Aprilia (LT) Tel. (06) 9281235/617 · Fax (06) 9281523

DERMATOLOGIA COSMETOLOGICA A cura di P. Morganti e L. Muscardin Ed. International Ediemme

Indice 1° Volume

Sezione I Considerazioni Generali 1 Cenni storici 2 La bellezza della figura umana

Sezione II Fisiologia e Biologia della cute 3 Sviluppo della pelle 4 La struttura della cute 5 Biochimica e Fisiologia dell'epidermide 6 Biologia del tessuto connettivo 7 Sistema Vascolare ed innervazione della cute

Sezione III La Cute come organo di assorbimento 8 Nozioni basilari sulla permeabili tà e sull'assorbimento 9 Membrane e assorbimento 10 Metabolismo della cute e degli annessi cutanei

Sezione IV Chimica e Chimico-Fisica dei preparati topici li Materie prime e principi attivi di uso cosmetologico 12 Emulsioni ed emulsionanti 13 Tensioattivi di uso cosmetico 14 Gli antiossidanti e i fenomeni ossidativi dei grassi 15 Antimicrobici e preservanti cutanei 16 La profumazione dei cosmetici 17 Chimica e tossicologia dei coloranti 18 Prodotti cosmetici in aerosol

Indice 2° Volume

Sezione V Trattamenti dermocosmetici del viso e del corpo 19 Detersione, protezione e normalizzazione della pelle 20 La cosmesi per l'uomo 21 Cosmetici per bambini 22 Preparati per il bagno 23 Maschere e peeling 24 I Depilanti

Sezione VI La cute senile 25 Invecchiamento cutaneo 26 n trattamento della cute senile

Sezione VII Cosmetici e Psiche 27 Aspetti psicosomatici e somatopsichici in

dermatologia cosmetologica

Sezione VIII I danni cutanei 28 Patologia cutanea da cosmetici su base immunologica 29 Danni da cosmetici

INFORMAZIONI PER L'ACQUISTO

Sezione IX Annessi cutanei e dermocosmesi 30 Ghiandole sudoripare e sebacee 31 Doodoranli e antisudore 32 Struttura e proprietà dei capelli 33 Detersione, protezione e normalizzazione dei capelli e del cuoio

capelluto 34 Cosmetici decorativi ad effetto duraturo 35 Le unghie 36 Prodotti decorativi ad effetto temporaneo superficiale

Indice 3° Volume

Sezione X Seborrea e dermocosmesi 37 Caratteristiche chimico--fisiche e funzioni fisiologiche del sebo 38 Produzione e modificazioni del sebo nel sano e nel seborroico 39 Influenza dei trattamenti cosmetologici sui lipidi di superfice del

viso e del capillizio 40 Attività ormonale e ghiandole sebacee 41 Il problema terapeutico dell'acne 42 Possibilità terapeutiche nella seborrea

Sezione XI Melanogenesi e dermocosmesi 43 Il sistema pigmentario 44 Filtri solari. pigmentanti diretti e depigmentanti

Sezione XII Mucose orali e dermocosmesi 45 La salute della bocca e dei denti 46 Profilassi ed igiene dei denti e della bocca 47 Preparazioni cosmetiche per la cavità orale

Sezione XIII Prodotti speciali 48 Omeopatia e cosmetici 49 So!Uzioni per lenti a contatto 50 Cosmetici ipoallergcnici 51 Cosmesi su basi naturali

Sezione XIV Trattamenti estetici correttivi 52 Interventi correttivi di chirurgia plastica 53 Laserterapia 54 Crioterapia 55 Principi di mesoterapia 56 Ionoforesi 57 Interventi correttivi di "camoumage"

Sezione XV Controlli dermotossicologici 58 Valutazione delle materie prime e dei cosmetici finiti 59 Controlli tossicologici delle materie prime e del prodotto finito GO Cosmetognosia. Funzionalità cd efficacia dei prodotti cosmetici

Sezione XVI Problemi normativi e cli Marketing 61 Nozioni di marketing e di pubblicità 62 Grafica pubblicitaria: implicazioni psicologiche 63 Normative di legge sui cosmetici nei vari paesi dcl mondo 64 La responsabilità civile dei trattamenti cosmetici 65 Giudizio medjco-legale del danno estetico

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INTERNATIONAL EDIEMME Via Innocenzo XI, 41 - 00165 ROMA e/e bancario n. 2961212 Banco di Santo Spirito Ag. 23, 00165 ROMA

O Prenoto fin da ora i volumi 2° e 3° Con la presente richiedo: Copie n . ........................................ del Volume n. 1

O Invio in contrassegno O Accludo assegno n .................................................................................................................................. (a pagamento quale anticipo di prenotazione)

TIMBRO E FIRMA

SpecificarecondizionidipagamentoefornireN° Codice Fiscale se è richiesta fattura.

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GEL IDRATANTE a fattore di idra­tazione 5. Reidratante cutaneo leggero per la pelle da normale a grassa. Arricchito con PCA noto componente dell'NMF, glicina, collagene "attivo" e filtri UVA- UVB.

IDRATAZIONE MEDIA per pelle da normale a secca

CREMA a fattore di idratazione 10. Idratante cutaneo per pelli da nor­mali a secche. Arricchita con acido gamma-linolenico, PCA, collagene "attivo", speciali umettanti, glicina e filtri UVA - UVB.

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GEL-EMULSIONE monodose, a fattore di idratazione 20, privo di conservanti. Idratante cutaneo per pelli particolarmente sensibili e disidratate ad alta concentrazione di principi attivi per tutti i tipi di pelle. Arricchito con acido gamma-lino­lenico, fosfolipidi, speciali olii rami­ficati e filtri UVA - UVB.

L'IDRATAZIONE E L'ASSORBIMENTO PROGRAMMATI CON PRECISI INDICI NUMERICI

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A new look at old skin: A challenge to cosmetology 1st lnternational Meeting on Cosmetic Dermatology, Rome, ltaly, March 7-9, 1985

Editors: P. Morganti, W. Montagna

Readership: Third year undergradua­tes, research workers in the field of Cosmetic Che­mistry, Biochemistry, Medi­cine, Pharmacy and Phar­macology, researchers and managers working in the cosmetic and phar­maceutical industries.

A NEW LOOK AT OLD SKIN: A CHALLANGE TO COSMETOLOGY Editors: P. Morganti, W. Montagna

The proceedings contained in this vo­lume provide comprehensive view of the different aspects of the skin aging with its cosmetologica! implications.

Contents (main chapters) The problems of the aged (R. Butler) Nutrition ond aging (M. Proja) Common structural changes in aging human skin (W. Montagna) An overview of physiological changes (8.A. Gi/chrest) The skin as a barrier and a homeostatic compar­tment of the body (G. Esposito) Skin collagen cross links natural and unnatural (J. P. Bentley) Aging changes in the mucus membranes (A. Jarrett) Changes in Cutaneous appendages (FJ.G. Ebling) Sebum secretion rates in relation to age: A new look (J.S. Strauss) Aging skln and Sun Damage (F Serri, L. Celleno) Sunlight, age and skin cancer (J.C. van der Leun) Stereology of the skin surface: a comparison betwe­en ageing and UV-induced damages (P. Corcuff) Cosmetic wrinkle smoothing (A. Meybeck) Collagen in cosmetic formulations: A contribution to research on aging skin (I. Beyssac) The cosmetic make-over in ederly women (A.M.Kligman) Essential fatty acids and skin aging (P. Morganti, S.D. Randazzo) Treatment cosmetics and aging (L.C. Calvo)

Proceeding of l .st lnternational Meeting on Cosmetic Dermatology, Rome, ltaly, March 7-9, 1985, 1986; 17-24 cm. 400 pages. Hardbound In ltaly L. 100.COO; ISSN 0393-5779

International Society of Cosmetic Dermatology

PRESIDENT

HONORARY PRESIDENT

VICE-PRESIDENTS

SECRETARY-GENERAL

PROGRAM DIRECTOR

BOARD OF TRUSTEES

ADVISORY BOARD

Coleman Jacobson (USA)

William Montagna (USA)

Fancis John Ebling (England) Emiliano Panconesi (ltaly) Rodolfo Paoletti (Jtaly)

Pierfrancesco Morganti (ltaly)

M. Brodie James (USA)

Pierre Agache (France) Fritz Kemper (Germany) Lawrence Parish (USA) W.E. Parish (England) Wolfgang Raab (Austria) Salvatore Randazzo (ltaly) Hans Schaefer (France)

William Abramovitz (Ve nezuela) Mohamed Amer (Egypt) Ruben David Azulay (Brasi!) C laude Benezra (France) I.A. Bernstein (USA) O. Binet (France) Otto Braun- Falco (Germagy) Peter Fri tzch (Austria) J. Morton Gillespie (Australia) Marwall Harahap (Indonesia) Vaino Hopsy-Havu (Finland) Stephanie Jablonska (Poland) A. Jarret (England) Jon Kabara (USA) F. Kardel Vegas (Venezuela) Ch.M. Lapiere (Belgium) Juhlin Lennart (Swedén) R.S. Lester (Canada) Howard Maibach (USA) Ronald Marks (Wales) Jose Mascara (Spain) J.P. Ortonne (France) G.E. Pierard (Belgium) Jaime Rubin (Argentina) Wolfgang Rupilius (Germany) Raul Vignale (Uruguay) Jacques Wepierre (France) Chu- Kwan Wong (Taiwan)

Trimestrale di Dermatologia Cosmetologica Quarterly Review of Cosmetic Dermatology

EDITOR

ASSOCIATE EDITOR

ASSISTANT EDITOR

EDITORIAL ADVISORY BOARO

P.MORGANTI PhD. SECRETARY GENERAL INTERNATIONAL SOCIETY of COSMETIC DERMATOLOGY Via lnnoccnw Xl, 41 -00165 Roma -(haly) - Fax 06/63.80.839

S.D. RANDAZZO M.D. Professor of EXPERIMENTAL DERMATOLOGY UNIVERSITY OF CATANIA Via Iacona, 7 - 951 24 Catania (ltaly)

M.B.JAMES M.D. PROGRAM DIRECTOR INTERNATIONAL SOCIETY of COSMETIC DERMATOLOGY JAMES CLINIC 34 Forcside Common Falmoulh, Maine 04105 USA - Fax 00 1-207-7755182

P.AGACHE G. BELLOMONTE W.F. BERGFELD B. BERRA R. CAPUTO O. CARLESIMO D.CERIMELE E. CHIACCHIERINI I.COTTE M.A. DINA F.J.G. EBLING G. FABRIZI A. FIDANZA D. GRAFNETTER J.A.GRAHAM B. GUARNIERI A.J. JOUHAR F.H. KEMPER A.M. KLIGMAN N.LOPRIENO S.MADDIN G. MAZZONE C.L. MENEGHINI W. MONTAGNA L. MUSCARDIN N. ORENTREICH E. PANCONESI R. PAOLETil W.E.PARISH G. PROSERPIO L. PUGLISI V.QUERCIA W.RAAB G. RABBIOSI A.REBORA V. RIZZA G. SALVATORE A.SANNA P. SANTOIANNI H.SCHAEFER F.SERRI A. SERTOLI A.STAMMATI I. TADDEI H. TRONNIER V. VALKOVIC

MD, Prof. of Dennat. Cenlre Hosp. Rcgional dc Bcsançon (F) CChem, Prof. of Chem., Food Deparl ls1. Sup. Sani1à - Roma (I) MD. FACP Cleveland Clinic Ohio (USA) DSc. Prof. o f Biol. Chem. Univ. of Milano (I ) MD, Prof. and Chainnan, Depart of Dermat. Univ. o f Milano 0) MD .. Prof. and Chairman Depart. of Dennat. Univ. of Roma (I) MD. Prof. and Chaim1an, Depart. of Dennat. Univ. of Sassari (I) CChem, Prof. and Chainnan, Depart. Tcchn. of Commcrcc Univ. of Roma (I) DSc, Prof. of Cosmel. IPIL Lyon (F) MD. Prof. and Chainnan, Depart. of Phatol. Anal. Ca1holic. Univ. of Roma (I ) DSc. PhD. Prof. of Zoology Univ. of Scheffield (GB) MD, Pacdriatic Dcmrntologist, Ca1holic University of Roma (I) DSc. Prof. and Chairman, Depart. of Physiol. Univ. of Roma (I) PhD. lnsl. for Clinica) and Exp. Medicine Prague (CS) B.Sc, PhD, Depl. Denna1ology Univ. of Pennsylvania (USA) MD, Prof. and Chairman, Dcpart. of Dcnnat. Univ. of Messina (I) M.B.MRSC Beaconsfield (GB) MD. Prof. and Chairman. Depart. of Phannacol. and Tox. Univ. Munster (D) MD, PhD, Prof. of Denna1ol. Univ. of Pennsylvania Philadelphia (USA) DSc, Prof. of Genelica Un iv. of Pisa (I) MD, ERCP Clin. Prof. Dcrmatol. Div. Derma!. Univ. BR. Columbia, Vancouver (C) MD, Prof. and Chairman, Depart. of Pharmacol. and Tox. Univ. of Catania {1) MD. Prof. and Chainnan, Depart. of Dermat. Univ. of Bari (I) DSc, Prof. of Dennat Oregon Healt Scicnce Universi1y (USA) MD. Prof. of Dennat. Centre Hosp. Regional IDI Roma (i) MD. Clin. Prof. of Dennal. New York (USA) MD, Prof. and Chairman. Depart. of Dermal. Univ. of Firenze (I) MD. Prof. and Chainnan. Depart. of Pharmacol. and Tox. Univ. ofMilano ([) MA, PhD, BVSc, Head of Environmenial Safe1y Division. Unilever Rcscarch Schan brook (GB) CChem, Prof. I ne. ofCosmcl. Chcm. Univ. ofTorino (I) DSc, Prof. of Phannacognosy Univ. of Milano (I) CChem, Prof. of Chem. Depart . of Phann. Chem. ls1. Sup. Sani1à Roma (I) MD, Prof. and Chainnan, Depart . of Dennal. Univ. of Wien (A) MD, Prof. and Chainnan, Dcpart. of Dcnnat. Univ. of Pavia (I) MD, Prof. and Chairman. Dcpart . of Dermat. Un iv. of Genova (I) Ph.D. Prof. of Biol. Chem. Un iv. of Caiania (I) CChem, Depart. ofToxicol. lsl. Sup. Sanità Roma (l) MD, Prof. and Chairman, Depart. of Microbio!. Catholic. Univ. of Roma (I) MD. Prof. and Chainnan, Depart. of Dennat. Univ. of Napoli (I) MD. PhD, Prof. and Chainnan, Depart. of Phannacol. CIRO Sophia-Anlipolis Valbone (F) MD, Prof. and Chainnan, Depart. of Dennat. Catholic. Univ. of Roma (I) MD, Assoc. Prof. of Allergie and Occupational Derma!. Univ. of Firenze (I) l?SC, Depart. of Toxicol. Is1. Sup. Sani là of Roma (I) B.Sc., Prof. and Chainnan. Depart. of Pharmacol. Science Univ. of Siena (I) MD, Prof. and Chairman, Depart. of Derma1ol. S1adtischen Kliniken of Dortmund (0 ) CChem, Prof. of Physic Ruder Boskovic' lnsl. ofZagreb (Y)

GENERAL INFORMATION The JOURNAL OF APPLIED COSMETOLOGY is an international journal devoted to publi sching o riginai papers, reviews and o ther materiai which represent a useful contribution to research on the skin and on cosme­tics. It is aimed at cosmetic chemists, dermatologists, microbiologists, pharmacists, experimental biologists, toxico­logists, plastic surgeons, and ali other scientists working on products which will come into contact with the skin and its appendages. The Joumal is publisched quarterly in English. It is distributed to cosmetic chemists, dermatologists, plastic surgeons, medicai and pharmaceutical schools. medicai libraries, selected hospitals and research institutions throught the world, and by subscription to any other interested individuals or organizations. Statements and opinions expressed are persona! to the respective contributors and are not necessari ly e ndorsed by the Editor(s), Advisers, Publishers of Distributors of thi s Journal.

COPYRIGHT Submitted materiai must be the originai work of the autor(s) and must not have been submitted for publication elsewhere. By submitting a manuscript, the authors agree that the copyright for their articles is transferred to the publisher if and when the artic le is accepted for publication. None of the content o f thi s publ ication may be rcproduced in whole or in parl, translated, stored in a retrieval syslem, or transmitted or distri buted in any form or by any means (elecu·onic, mechan ical, photocopy, recording or otherwise) without the prior written permission of the Publ ishers.

Sections of Journal

The fo llowing sections will be features of the Journal:

Originai Laboratory Studies: descriptions of originai investigative laboratory research in cosmetics and rela­ted areas.

Special Reports: Items of special interest to the readers, including reports on meetings, societies, legislation, etc.

Generai Articles: scientific articles of generai interest to our readers will be considered for publication. These articles should be concerned with newer developments in such related fields as dermatology, biology, tox ico­logy, etc.

Short Communicatio11s: the lenght shou ld not exceed 5 typewritten pages with not more than 3 fig ures included. Headings ("Materials", "Discussion", etc.) as well as Summaries are to be omitted. If accepted, these submission will appear in print in a very short time.

Letter to the Editor: comments on Journal articles are invited as well as brief contributions on any aspects of cosmetic science. Letters may include figures, and/or references, but brevity is necessary.

Guest Editorials: concise, authotitative, substantiated commentary on specific topics of contemporary interest.

Book Reviews: book and monographs (domestic and foreign) will be reviewed depending on their interest and value to subscribers. Send materiai for review to the Editor, Dr. P. Morganti. No such materiai will be returned.

Address: ali papers should be submitted to: Dr. P. Morganti INTERNATIONAL EDIEMME Via Innocenzo Xl , 41 00 165 Rome - Italy Tel. 06/637.87.88

INFORMATION FOR AUTHORS

Papers must be submitted in English. Authors whose mother tongue is not English should arrange for their manuscripts to be written in proper English prior to submission.

Procedure of Submission of Manuscripts: submit three copies of both the manuscript and ali illustrati ve materiai to the abòve address.

Orga11izatio11 of the Ma11uscript: investigative studies should be organized as follow: tit le, abstract page, introduction , materiai and methods, results, di scussion, acknowledgments, references, legend for fi gures, tables. Ali pages should be numered consecutively starting with the abstract. The entire manuscript is to be typewritten, double-spaced, and with 3 cm margins. Trade names must be capitalized: the common name for compounds may be used if the formai chemical name as established by international convention is given after the first use . Any abbreviations other than those which are generally accepted must be defined. In the text, references to dual authors will use both surnames throu­ghout. For multiple authors, use the surnames of ali authors at the first reference and only the first author fo l­lowed by "et al." thereafter. Please mark in the margin of the manuscript the desired position of the figures and tables. To allow faster publication only set of proofs will be furni sched to the author including the figures and tables in their fina l position. ~

Title page: list the title, name(s) and degree(s) of author(s), department(s) and instillltion(s) at which the work was done, city, state, and postai code. Any preli minary report or abstract of the work should be referred to as a footnote to the title.

Su111111ary: each paper must be headed by an Engl ish language title of not over 70 characters (including spa­ces) suitable for use as a running head and must also be proceded by an English summary not exceeding 300 words typed double-spaced. The summary wi ll include statements of the problem, method of study, results, and conclusions. Since thi s summary will be used by astracting journals, it must be self- explanatory and shou ld not inlcude abbreviations, footnotes, and references.

Foot11otes: should be listed consecutively at the bottom of the page on which they fa ll , designateci by the fo l­lowing symbols in order *, +, +,§, II,**, etc.

Key Words: key words for computerised storage and retrieval of information should be incorporateci in the summary.

Refere11ces: the references have to be abbreviateci as listed in the Index Medicus. The style of the references must confonn to the examples given below: I) Robbi ns CR, Kellych (1970) Aminoacid composition of human hair. Text Res J 40:89 1-896 2) Strehler BL (1977) Time, cells and aging 2nd edn. Academic Press, New York 3) Ebling FJ , Rook ( 1972) Ciclic activity of the fo ll icle. In: Textbook of dermato logy 11 , Blackwell, Oxford, p. 1567- 1573.

Jllustratio11s: figures should be numbered consecutively using Arabic numerals Tables should be numbered consecutively, using Roman numerals. Ali photographs should be black and white, glossy and unmounted. The number and size of illustration should be restricted to the minimum needed to clarify the text. Authors requi­ring extra space for illustrations will be charge accordingly. This is also the case for color illustrations. Ali figures, photographs, graphs, or diagrams should be submitted on separate sheets.

Animai Experiments: descriptions of animai experiments should include full details of the types of animai used (inbred, etc.) and the condi tions under which they were kept (standard diet , etc.).

Trade Names: ali common cosmetic ingredients should be referred to by their generic names, as indicateci in the latest edition of CTFA Cosmetic Ingredient Dictionary, and the European Pharmacopeia. Ifa materials is not listed, then the trademarked name can be used, with the chemical composition given in footnotes.

STAMP

Spett. Direzione "JOURNAL OF APPLIED COSMETOLOGY" INTERNATIONAL EDIEMME Via Innocenzo Xl, 41 00165 ROMA (ITALY)

STAMP

Spett. Direzione "JOURNAL OF APPLIED COSMETOLOGY" INTERNATIONAL EDIEMME Via Innocenzo Xl, 41 00165 ROMA (ITALY)

Trimestrale di Dermatologia Cosmetologica Quarterly Review of Cosmetic Dermatology

Contents

Generai Articles

25 Tolerance of the lesioned skin to dermatological formulations B. Gabard. Th. Nook and K.H. Muller

3 l Contact allergie dermatitis: the need tor consistency in data collection and analysis M.F. Wood er and C. Koc h

Originai Laboratory Studies

35 Contact allergy to preservatives in cosmetics and relationship to the degree of formaldehyde allergy G. Richter and J. Barth

40 Book Review

XIX Announcements

4th lnternational Meeting of lnternational Society of Cosmetic Dermatology "Progress in Cosmetic Dermatology: Science and Safety" Rome - ltaly October 30-November 2, 1991 Preliminary Program

18° World Congress of Dermatology New York City - from June 12-18, 1992

J. App/. Cosmetol. 9, 25-30 (Aprii - June 1991)

TOLERANCE OF THE LESIONED SKIN TO DERMATOLOGICAL FORMULATIONS B. Gabard*, Th. Nook and K.H. Muller *Department of Biopharmacy, Spirig AG, CH-4622 Egerkingen (Switzerland)

Received: October 26, 1989: Presented at at 3rd lnternational Congress on Cosmetic Der­matology "Progress in Cosmetic Dermatology" - 27 - 29th October 1989, Wien

Key words: lrritation: Scarification: Stripping: Na-Lauryl Su/fate: Propylene Glycol: Urea: Os­molarity; pH; Antimicrobials.

----------------- Synopsis Dermatologica! formulations often are appl ied on les ioned skin in the course of the treatment of for example d ry skin, eczema or atopic disease. Therefore we felt it important to devise a test for quan­tification of the tolerance of these formulations. For this purpose, the horny layer was tape-stripped unti! the transepidermal water loss (TEWL, as measured under standard conditions) attained 40-50 g/cm2h. This needed approximately I 0-15 strips. After an interval of at least 30 min during which the TEWL decreased to values of 30-40 g/cm2h, the test products were applied to the stripped area and the reactions were assessed by the volunteer accord ing to a 4-point scale during and immediate­ly after the applications. Standards were used for quantification, identification and comparison pur­poses: NaCI (0.l -10%), Urea (0.5-20%) and Propylene Glycol (l-70%). In addi tion the pH of the test solution was varied between 3 and 8. Curves relating-effect to concentration allowed more precise assessment of the relative roles of the different components of formulations. For example, Urea and Propylene Glycol may lead to buming reactions on lesioned skin at the concentrations usually found in dermatologica! products. Similarly, antimicrobials in permitted concentrations may play a role in these reactions.

-----------------Riassunto Le formu lazioni dermatologiche vengono spesso applicate su cute lesa per eccessiva secchezza, per la presenza di eczemi o di dermatiti atopiche. È perciò importante che venga accuratamente valutata la tolleranza di queste formulazioni. A que­sto scopo sono stati eliminati mediante "strappo" alcuni strati del corneo fino ad ottenere una TEWL di 40-50 g/cm2 h. A tal riguardo sono necessari circa 10/15 "strappi". Dopo circa 30 minuti durante i quali i valori TEWL raggiungevano il valore di 30-40 g/cm2/h veni­vano applicati i prodotti da sperimentare sulle zone impoverite di corneo. Rilevando la reattività ottenuta mediante una scala d i valori numerici prima e dopo l 'applicazione dei prodotti è stato possibile controllare il grado di tolleranza di alcune materie prime di uso corren­te, quali ad esempio l'Urea ed il glicol propilenico. È stata verificata anche l'influenza svolta dal pH, e dalle diverse concentrazioni d ' uso permesse.

25

Toterance of the tesioned skin to dermatologica/ formulations

Professor Albert Kligman wrote in 1982 (1): "In our age of skin consciousness and abundant use of cosmetics and toiletries awareness is growing that the great majority of undesired reactions represent irritancy." And further: "The biologie truth is that a li substances are irritating for some persons under some conditions, although ex­treme exposures may be necessary to bring this to light." End of citation. The problem of irritation is far from a theoreti­cal one. Irritation could be tentatively defined as a very generai notion for undesired reactions. These can widely vary in their intensity, in their manifestations and in the moment they will be perceived as such because people differ enor­mously in their susceptibility to irritating sub­stances and because the reactivity of the skin is influenced by many factors. In addition, topica! preparations, whether drugs or cosmetics, are often applied to damaged skin . Indeed, it is surpris ing how often creams or ointments are used as home remedies for burns, abrasions, bites, and rashes of ali kinds. Hence it is not out of order or unrealistic to as­sess the probability of a substance being irrita­tive under the most extreme conditions. This permits discrimination among the test products because reactions are sufficiently intense also

METHOD

Stripping Application

l l Rest

26

allowing some standardisation. For this purpose, we must make sure that the substance reach the viable tissue under the horny layer. The barrier can be eliminated by scarification, as in the scarification test of Frosch and Kligman (2) or by tape stripping. Testin.g products on damaged skin is also necessary if, as in our case, are pri­marily aimed at ili people. Among the many reactions of the skin which could be c lassified under irrita tion we were especially interested in those called " invisible reactions" by Professor Kligman (I). Topica! preparations can cause disagreeable sensations - burning, itching, stinging - immediate ly after appli cation and will be rejected by the con­sumers, especially in pediatrics. These prepara­tions are not irritative in the ordinary sense and usually do not damage the skin. The reactions can be very intense and unpleasant, and this is why we feel it important, for the products we are selling, to try to evaluate such immediate reactions. For a li these reasons, we performed the tests on stripped skin and recorded immediate reactions. We used the following method (Fig. l): On the ventral side of forearms, up to 5 areas of ap­proximately lx2 cm were stripped. Stripping was continued unti! the transepidermal water

Reaction Mean Score

o g <0.5 absent

1 g 0.5 - 1.0 slight

2 8 1.1 - 2.0 moderate

3 · Q 2.1 -3.0 severe

FIGURE 1

loss a tta in ed 40-50 g/m 2xh w hi c h us ua ll y needed l O to 15 strips. T hereaf ter, a rest ing period of at least 30 min was observed, during which the transepidermal water loss stabilised around values of 30-40 g/m2xh and the sensa­tion of irri tation due to the stripping vanished . The test products were applied on the stripped area taking care to avoid or mi nimalise any me­chan ica l st imu lat ion. Li quid p rod uc ts were dropped on the skin with a pneumati c pipette, c reams and ointrnents were careful ly pasted on the stripped surface. The test products remained on the stripped area for a maximum of 3 min. Im mediate sensations, mainl y burn ing, were graded on a four point scale from O (no reac­tio n), I (s light), 2 (moderate) to 3 (severe). Mean scores were calculated and the results ex­pressed as < (lower) 0.4 (no reaction), 0.5 to 1.0 (s lig ht), I. I to 2.0 (moderate) and 2 . 1 to 3.0 (severe). This gradation has also been used by Frosch and Kl igman to class ify the irrita tio n measured with the scarifi cation test thus ena­bling comparisons to be made, a lthough we are aware that the two phenomena are comple tely different in their nature. First, we investigated reactions to di fferent clas­ses of substances used in topica! formulations such as su rfacta nts, pe ne tra t ion enhancers , moisturizers, a li in aqueo us solutions. Sodium Laury l Sulfate (Fig . 2) is a good example to s ho w the d iffe rence we fo un d be tween th e scarifi cation tes t and o ur tes t. T his agent is

Na Lauryl Sulfate Score

2.5 1------ -----------t

21----------------t

1.5 1------ ------ - - - -t

0 <..i..:::::::t:-,..,___.,...,...-.,.,._.....,..,,_~_,,'::-~---:,..,___. o 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9

Concentration {%) O Stripped: 8 volunteers D Scarlfied : Data from ref.2

L--------------~FIGURE 2

B. Gabard. Th. Nook and K.H. Mu/ler

known to irri tate the normai skin at the con­centrations we used and scarification greatly reduces the irritation th reshold. Immediate reac­tions were almost absent up to the concentratio n of I%. On the contrary, Propylene Glycol (Fig. 3), which is incorporated in many topica! for­mul at ions as a penetra tio n enhancer, readi ly provoked burning sensatio ns when applied on stripped skin but showed a low irritation poten­ti al in the scarification test.

Propylene Glycol Score

3 .------ -------,...-------, o

0 0!--~1~0___,2~0-3~0-~40,..-~50,..-~60,..-~10=-~s~o ---,00'='-""':":!100 Concentration {%)

O Stripped: 6 volunteers D Scarilied: Data from ref.2 ...._ ______________ FIGURE 3

Urea (Fig. 4), as a moisturizer, led to a measura­ble rate of immediate reactions without g reat dependency on the concentration. Interestingly, higher concentrations did not much enhance this rate, which was almost comparable to the resul ­ts obtained after scarification. Among other factors which could have a major impact on the rate of immedi ate reactions of

Urea Score

3.------------- ----.

0 0!---~s----..,1~0----=15,..----,2~0-~2~5--.,,3~0-~35

Concentration (%) O Stripped: 6 volunteers D Scarified: Data from rel.2

.__----------- ---FIGURE 4

27

Tolerance of the /esioned skin to dermatologica/ formulations

stripped skin are the osmolarity and the pH of topica! formulations . Osmolarity (Fig. 5) was

NaCI Score

5 7.5 10 12.5 15 17.5 20 22.5 25

Concentration (%) O Stripped: 6 volunteers O Scarified: Data from ref.2

L--------------~FIGURE5

in ves tigated with different concentration s of sodium chloride. An inte resting findin g was a measurabl e reaction score for distilled water, perhaps d ue to excessive hypoosmolarity. The score a lways diminished if a low concentration

of sodium chloride was present. The dependen­cy on osmolity was steep, again showing a

Score pH

3

2.5

o

~ o~ -

2

1.5

0.5 ~ o ~~

o 2 3 4 5 6 7 8 9 10

pH 6 volunteers

..._ ______________ FIGURE 6

marked diffe rence with the scarification test. lsotoni c buffers of different pHs (Fig. 6) bet­ween 3 and 8 markedly influenced the score of the reactions. Most intensive responses were recorded with a pH under 4.

Table I

Antimicrobial

Triclosan

Chlorhex idine dihydrochloride

Hexamidine isethionate

Phenyle thy la lcohol

Phenoxyethy la lcohol

Trilclosan + Chlorhexidine

Trilclosan + Phenox yethy lalcohol

28

Concentration %

0.3

0.3

0.3

O.S

0.S

2.0

0.3 0.3

Score

0.4

O.S 0.8

o

0.S

2.8

0.2

Vehicle

O/W cream

O/Wcream

O/W Lotio I Urea 2%

0 /Wcream

O/Wcream

O/Wcream

O/W cream ---------~I-------------~-~--------------~~;-~,~e~~ --------l.O W/0 Lotio I Urea 2%

At this stage of the experiments, one could ten­tatively summarized that for our purposes, a to­pica) product should show a neutra! pH and a low osmola rity. Penetration enhancers and moi­stu ri zers should not be present or their use should be carefu lly conside red. lt is known that other important factors which often lead to disagreeabl e reactio ns are an­timi crob ial agents . Some re le vant data are shown in Table I. In terestingly, we did not find high reaction scores for an timicrobial s incor­porated into suitable vehicles in permitted con­centrations except for Phenoxyethylalcohol. Ad­dition of urea slightly enhanced the scores as anticipated. Combination of two antimicro bia ls did not genera lly lead to higher scores, again with the exception of Phenoxyethy la lcohol.

B. Gabard, Th. Nook and K.H. Muller

Last but not least, although we feel that im ­mediate reaction s are very important for the success of a product, the long-terms irritative potentia l should not be neglected. As pointed out in thi s communication, the test on stripped skin and the scarification test lead mostly give different results and are not predictive of each othe r. This was confirmed with a syndet (Table 2). That is, we do not replace the evaluation of a poss ible irrit at io n as pe rform ed wi th the scarification test by scoring immediate reactions afte r application of the produc t on stripped skin. Rather, we conside r both tests as independent but useful complements integrated in a product development scheme as an optimi zation of der­matologica! formulation s before going on the market.

Tabi e Il

Washsyndet

Antimicrobial s: Triclosan 1,0% Bronidox 0,2 %

Test Score ------------------------------------------------------------------------------Stripped l .4 Scarified 2 . 3

5 volunteers

29

Tolerance of the lesioned skin to dermatologica/ formulations

Acknowledgement Thanks are due to E. Bieli for her skilfu l technical assistance.

References 1. Kligman AM (1982): Assessrnent of rnil d irritants in: "Principles of cosmetics far the der­

mato/ogist", Frost P. and Horwitz SN eds., The CV Mosby Cornpany, St. Louis Toron to London , pp. 265-276.

2. Frosch P J Kligman AM (1978): "An irnproved procedures for assaying irri tants: The scarifica­tion test" Current Problems in Dermatology 7, 69-79.

30

J. Appl. Cosmetol. 9. 31-34 (Aprii- June 1991)

CONTACT ALLERGIC DERMATITIS: THE NEED FOR CONSISTENCY IN DATA COLLEC­TION ANO ANALYSIS

M.F. Wooder and C. Koch ROHM a nd HAAS EUROPE, Lenning House 2 - Ma ison's Avenue Croyd on Surrey

Received: October 26, 1989: Presented at at 3rd lnternational Congress on Cosmetic Der­matology "Progress in Cosmetic DermatologyH - 27 - 29th October 7989, Wien

Key Words: Prevalence rate: Relevance: Jnter-clinic; Variation: Patch testing: Contact al/er­gy; Dermatitis.

Synopsis

The ala1m that c linical skin a lle rgy reports generate is in some cases greater than that generated by reports of carcinogenicity e.g. c igarette smoking. It would be necessary for the medicai community to educate the lay pubblic that the reported prevalence rates are cl inical and therefore of not d irect relevance to the generai population. It would be also of paramount importance to educate the public to realise that a positive patch-test is not, of itself, proof that the current clinical cond it ions was caused by that a llergen.

Riassunto

L'attenzione che il grande pubblico riserva agli articoli riguardanti le allergie cutanee è spesso supe­riore dell ' analoga attenzione rivolta a i rapporti sulla carcinogenesi provocata dall ' uso delle sigaret­te. Sarebbe auspicabile, quindi che la classe medica educasse il pubblico a valu tare piu attentamente i dati clin ici perché non sempre l'a lle rgene evidenziato è il vero responsabile d i un dato quadro cli­nico e non sempre la specifica reattivi tà cutanea di poch i individui e estensibile ad una vasta popo­lazione.

31

Contact allergie dermatitis:the need tor consistency in data collection and analysis

There is currently a heightened awareness, on the part of the generai public, of the problems associated with skin allergy, contact allergie dermatitis. This awareness, particularly in the area of cosmetics and toil e tries, is in som e respects a consequence of our consumer con­scious society and i fuelled , at least in part, by reports in the popular media derived from clini­cal data. Data are.published by the practitioner in medicai Journals such as the Lancet and Con­tact Dermatitis, and these are now common hunting grounds far scientific journalists. The concern and a larm that these a ll e rgy reports generate, can in some cases be greater than that generated by re ports of carcin ogenicity e.g. c igarette smoking . r be lieve that , given thi s cl imate, it would be timely far the medicai com­munity to educate the lay public to realise that the reported prevalence rates are clin ica! data, relating onl y to the c linic of generation and therefare not of direct re levance to the generai population. What the n is a prevalence rate? Within the individuai c linics the prevalence rates are an expression of the number of patients with patch positive responses relative to a g iven

PATIENTS WITH DERMATOLOGICAL PROBLEMS

l

Dl~~:."sE ~-1

CONTACT DERMATITIS

IRRITANT ALLERGIC !

COSMETIC +--- PATCH TEST

J: I

NEGATIVE l {RELAVENT

POSITIVE

IRRELAVENT

32

baseline clinical population. The choice off th is baseline population varies from clinic to clinic and so therefore do the prevalence rates. As an example of how the prevalence rates vary with the choice of denominator, cons ider the fallow­ing simple model. Figure I shows the schematic tlow of patients presenting with dermatological problems to the dermatology clinics. ff actual patient numbers (de Groot 1988) are now supe­rimposed on this scheme we arrive at the situa-

' tion shown in figure 2. Using as the denomina­tor far our calculation of prevalence rates the to­ta! number of patients attending the clinic, the tota! number patch tested (suspected of contact a llergie dermatitis) or the number diagnosed as suffe ring from cosmetic alle rgy we can calcula­te the prevalence rates shown in table I. As you can see they vary by severa! o rders of mag­nitude. If this exerc ise is repeated, far example, with the group of patients with positive patch test reactions to biocides we get a similar set of disparate results. This highlights one of the in­herent problems in comparing data reported by different practitioners with that in the medicai literature (Wooder and Koch 1988). In addition,

PATIENTS WITH DERMATOLOGICAL. PROBLEMS

l 15522

Dl~~~"sE~-1

CONTACT DERMATITIS

IRRITANT 1403 ALLERGIC !

49 COSMETIC+---PATCH TEST

J: I

NEGATIVE l {RELAVENT

POSITIVE

IRRELAVENT ....__ ______________ FIGURE 2

these prevalence rates re late only to the clinica! population under s tudy and not directly to the gene rai public i.e . the measure of ri sk that we have comes not from the normai population but from patients patch-tested in the dermatology c lini c s . Thi s o b v io us ly pro v ides a biased population, as people only a ttend such c linics if they have skin pro blems, and the number of patc h tes t po s iti ve reac ti o ns seen by d e r­matolog ists is bound to be greate r than that you would expect to find in the normai population. Thus the high prevalence of positive patch-test reac tion s in pa ti ents a ttendin g de rmatology c linics mean little mo re than the finding tha t the re is a hi g h pre va le nce o f hy pe rg ly­ce mi a/hy pog lyce mi a in pa ti e nts a tte ndin g diabe tes cl inics. lt is also of paramount impor­tance that the public is educateci to realise that a positive patch test to a particular a llergen is not, of itself, proof that the current c linica( condi­tions was caused by that allergen, i.e. whereas a

M. F. Wooder and C. Koch

negative test does not necessarily mean that the patient has a sens iti v ity which is re levant to the ir c urrent c linica! problem. Relevance of positive patch-test reactions has become a major area of concern for those working in the fie ld of contact dermatitis. The reason that many positi ­ve reactions are not re levant is that the e lic ita­tion of sensitisation is not ali or none phenome­non. Like the majority of effects seen in pha r­maco logy and tox icology, skin sen siti sation shows c lear dose response re lationships. Thus a lthough the patient may react to a chemical in a patch-tes t at a pa rticula r concentrati on, they may never react to the much lower concentra­tions that they a re exposed to in every day li fe. In other words, the patch-test response gives the most pessimistic measure of risk rathe r than the actua l risk. Thus il would be he lpful if the term prevalence was used in a more precise way, i.e . e ither by carefull y defining on each occasion, the group

Table I

EFFECT OF DENOMINATOR ON PREVALENCE RATES

BIOCIDE No TOT AL SUSPECTED COSMETIC BIOCIDE POSITIVE PATIENTS CAD ALLERGY ALLERGY

------------------------------------------------- ------- -----------------------Benzoxonium Chloride I 0.006 0.07 2.04 10

Chloroacetamide I 0.006 0.07 2.0~ 10

Formaldehyde I 0.006 0.07 2.04 IO

lmidazolidinyl Urea I 0.006 0.07 2.04 10

Kathon CG 3 0.02 0.21 6.12 30

Parabens I 0.006 0.07 2.04 IO

Quatemium-15 2 0.012 0.14 4.08 20

DeGroot 1989

33

Contact allergie dermatitis:the need tor consistency in data collection and analysis

to which it applies, and therefore the groups to which it does not apply, or better stili agreeing a standardi sed defin ition that would allow genui­ne comparison of the valuable data from diffe­rent c linics. In the same context I would also suggest that we need mo re information on the popula tion prevalence rates. These additions, would I believe, greatly enhance good clinica! and epidemiologica! practice.

Table Il

EFFECT OF DENOMINATOR ON PREVALENCE RATES

CLASS OF No TOT AL SUSPECTED COSMETIC INGREDLENT POSITIVE PATIENTS CAD AL LERGY

-------------------------------------------------------------------------------Fragrances 28 0.18 2.0 57

Biocides IO 0.06 0.71 20

Emulsifiers 4 0.03 0.3 8.16

Miscellaneous 9 0.06 0.64 18.37

DeGroot 1989

References

1. De Groot AC (1988): "Adverse reactions to cosmetics" Thesis Rijksuniversiteit Groningen. 2. Wooder M.F. and Koch C (1988): "Kathon CG - A 15 year experience" Poster presentation,

Forum Cosmeticum, Basle.

34

J. Appl. Cosmetol. 9, 35-38 (Aprii - June 1991)

CONTACT ALLERGY TO PRESERVATIVES IN COS­METICS ANO RELATIONSHIP TO THE DEGREE OF FORMALDEHYDE ALLERGY

G. Richter* and J. Barth *Klinik tor Hautkrankheiten Medizinische Akademie "Cari Gustav Carus" DDR-8019 Dresden, FetscherstraBe 74

Received: October 26, 1989: Presented at at 3rd /nternational Congress on Cosmetic Der­-matology "Progress in Cosmetic Dermatology" - 27 - 29th October 1989, Wien

Key words: Allergy: Formaldehyde: Formaldehyde Releasers: Cosmetics

________________ synopsis

In 6200 patch test series performed because of the tentati ve diagnosis "contact dermatitis" we found 497 (8.0%) positive patch test reactions to potential ingredients of cosmetics, 221 (3.6%) of them at ali relevant and only 8 (0. 1 %) due to formaldehyde releasers (FR). Test series with d ifferent formaldehyde concentrations and FR in 140 patients suffering from proven allergy to formaldehyde revealed: The potenti al hazard of allerg ie side effects varies among the different FR and is correlated with the degree of fonnaldehyde sensitivity.

Riassunto

Nel tentativo di giungere ad una diagnosi certa si sono eseguiti 6.200 patch test predittivi. 497 (8%) delle risposte positive sono da addebitarsi a ingredienti cosmetici. La reattività è molto evidente in 221 (3,6 %) patch test e soltanto 8 (0, I %) risposte positive sono attribuibi li a composti donatori di formaldeide. È stato, inoltre, rilevato che il grado di positività ri ­scontrata per la presenza dei donatori di formaldeide e direttamente correlabile al grado di sensibi­lizzazione alla formaldeide dei soggetti esaminati.

35

Contact al/ergy to preservatives in cosmetics and relationship to the degree of formaldehyde A/lergy

Cosmetic-related a lle rg ies are the subject o f numerous publications. So w ill only briefl y presen t ou r ep idem iolog ica! data, whi ch is limi ted to emul s ifie rs and preservati ves, and draw attention to possible correlations wi th the formaldehyde a lle rgy. 7254 patients were patch tested because of a tentati ve diagnosis of "contact dermatitis or ec­zema", 5470 w ith the GDR-standard series, containing wool alcoho ls and parabens, and 620 with a specia l series (emuls ifiers and preserva­tives); a ltogether 6200 patients were tested with potentia l ingred ients of cosmetics. In tab le I the statistica( results from our com­puter s tored data a re s ummari zed. Th e re levance was determined on the bas is of case his to ry and medi ca i examination. This table shows two things: first the well known fact that side effects from addi tives are much more fre­que nt in the rapeuti c preparations, applied to damaged skin and probably containing othe r powerful sens iti zers, than in cosmetics. The re lati on 221 :45, that is about 5: I , agreed wi th

other published experiences in this fie ld. Secondly we can see tha t the ranking lis t of such allergens depends on the frequency of pe r­formed tests and on the duration and amount of exposure. Parabens have for many years been the bas ic preservatives in nearly ali vehicles of the o il in water-type, produced in the GDR. Piasolan®, an imidazolidinyl urea like Germall®, has been used for about LO years, Bronopol® and Kathon CG® since 1985. The "othe r preserva­tives" include sorb ic acid, gallates and benzal­conium chloride, up to now(l989) no Kathon CG®. From the 8 cosmetic-re lated a lle rg ies to formalclehyde re leasers (FR) only 5 also showed a formaldehyde a llergy. As these substances are no part of the standard series, a lot of sensiti za­tions may have been undetected. On the othe r hand , formaldehycle has unquestionably been the major a llergen in the GDR for many years, espec ially in young women, that is in persons who no rmally use a lot of cosmetics. So we considered whether cosmetic intolerance might be re lated to formalclehyde allergy.

Table I

POSITIVE PATCH TESTS

Emulsifiers tot al re levant at a li cosmetic related Preservati ves

Wool alcoho ls 156 99 12

Other emulsifie rs 27 18 5

Parabens 155 83 15

Formaldehyde-releaser 46 14 8

Other preservatives 13 7 5

-------------------------------------------------------------------------------Tota! 497 221 45

% of 6200 test series 8.0 3.6. 0.7

36

In coopera tion with Rothe and Zschunke from the Centrai Institute of Occupational Medicine

. in Berlin we tested th is series (upper line) and in our department, moreover, these additional formaldehyde concentratio ns . In 20 patients, most of them wi th minor symptoms or a family history of atopy, repeated contro! tests revealed s light irritant reaction s to the I % and 0.7 % preparations. It s hou ld be kept in mind that these generally recommended concentrations might g ive rise to fa lse positi ve reactions in severa! cases. The vehic le of the FR (ungt. emuls. aquos.) is the o/w-emuls ion of our phar­macopoeia and the basic vehicle in this type of cosmetic. In the rema ining 140 subjects, suffering from proven allergy to formalclehyde, confirmed by repeatecl patch testing ancl aclditionally by the case history and c linica! pattern, we obtained these results: Two aspects a re of cosmetica! interest. I.: The potential hazard varies distinctly among the different FR. It is low for Bronopol®, some­what higher for Germall® and Piasolan®, respec­t i ve ly, a ncl c le arly hi g her in Dow ic il 200®. Grotan BK®, a biocide in cutting fluids, is the strongest alle rgen and clearly re leases the most formaldehyde. Among these 3 preservatives the

G. Richter ond J. Borth

amount of free formald ehyde in fresh and 3 month s tored pre pa ration s, res pec ti ve ly, decreased from Dowicil 200®, set as I 00%, to a bo ut 50% in G e rm a ll 11 5® and 20% in Bronopol®, as described by HABEL. This is the same order as in most other published ranking li sts of contact alle rg ies to cosmetics, for in­stance those by FISHER, DE GROOT or EIER­MANN. Though only a part of the allergies to such preservatives is coupled with a formal ­dehyde allergy, their sensitiz ing potency is ob­viously re la teci to the amount of released for­maldehyde. 2.: The frequency of positive tests due to FR is significantly correlated with the degree of hy­persensitivity to forn1aldehyde (p <O.O I). Hence it fol lows that especially in persons with highly marked hypersensitivity to formaldehyde FR in cosmetics are capable o f provoking relap­ses o f a llergie dermatitis. But even these posi­tive patch test reactions do not automaticall y imply an intolerance of cosmetics. Only 5 of the 66 a lle rg ie women, tested in Dresden, had a con firmed case his tory of contact dermatitis from skin care products containing FR. None had problems with rinse off products. So we believe, that patients with formaldehyde allergy, provided it is not an extreme one, need not com-

Table Il

SUBSTANCES, CONCENTRATIONS AND VEHICLES USED IN PATCH TESTING:

Formaldehyde 0.7%, 0.35%, 0.2%, 0.05% w. (additional in 86 patients from Dresden formaldehyde I% pet. , l % and O. I % w.)

Piasolan 2%, Dowicil 200 and Germall 115 1 %,

Bronopol 0 .25% in ungt.emuls.aquos.

Grotan BK I% w.

37

Contact allergy to preservatives in cosmetics and relationship to the degree of formaldehyde Allergy

plete ly avoid cosme tics preserve d by s uch chemicals. But to prevent adverse effects from possibly incorporated FR, they should perform a repeated open application test before using a new, unknown cosmetic.

Table lii

Reactivity Degree of hypersensitivity toFR to formaldehyde (% w)

0.7 0.35 0.2 0.05

Bronopol I I 3 Germall 115 2 5 2 Piasolan 2 7 4 Dowicil 200 I 4 16 14 Grotan BK 3 14 42 19 FR negative 17 23 Il o

No. of subjects 21 40 59 20

References

Positive reactions

tota!

5 9

13 35 78

-

140

1. Eiermann, H.J., Larsen, W., Maibach, H.I. and Taylor, J .S (1982).: Prospective study of cos­metic reactions: 1977-1980. J. Am. Ac. Derm. 6 909 - 917

2. F isher, A.A.(1978): Dermatitis due to formaldehyde-releasing agents in cosmetic and medica­ments. C utis 22 665-664

3. De Groot, A.C . a nd Bos, J .D .(1987): Preservatives in the European standard series for epicutaneous testing. Brit. J. Derm. 116 289-292

4. Habel, U.(1989): Zur Problematik der Konservierungsmitteliiberempfindlichkeit unter be­sonderer BerUcksichtig ung einiger fonnaldehydabspaltender Konservierungsmittel. Dissertation (A.), Med. Akademie E1furt.

38

40

BookReview

Series Editor: P. Morganti

2

INTERNATIONAL EDIEMME Edited By: P. Morganti, F.J .G. Ebling

BookReview

Cosmetic Dermatology

Series Editor: P. Morganti

Volume 2 Every day Problems in Dermatology: The Cosmetic Connection

Editors: P. Morganti, F.J.G. Ebling

Every day Problems in Dermatology: The Cosmetic Connection is the second addition to the Cosmetic Dermato/ogy Series

This book is comprised of 41 previously unpublished papers dealing with research in various fields of cosmetic dermatology. The main themes covered are: inter-relationship between drugs and cosmetic in the skin ; the efficacy of, and the raction to, cosmetics; cosmetics in sport s and work; cosmetics in relation to sexuality and pregnancy; and finall y, the interconnection existing between cosmetics and die t. By so comprehensively covering the science of cosmetics, this text is indispen­sable to those involved in research and development for the cosmetics, toiletries and pharmaceutical industries. It will also be a great benefit to university and hospital pharmacists and health care pro­fessionals entrusted with any aspect of skin care.

CONTENTS (Main Chapters) Psycological aspects of every day cosmetic dermatology (E. Panconesi) Cosmetic, drugs and common skin disorder (W. Raab) Percutaneous absorption and lipids of the elderly skin (J. Wepierre) Mechanism of solar erythema (E. Quencez, P. Agache) The skin plasticisation effect of a medium chain alpha-hydroxy acid and the use of potentiators (J .C. Hill , R.J . White, M.D. Barrai, E. Mignini)

Analytical problems of cosmetic evaluation resulting from EEC ltalian regulatory procedures (L. Gagliardi, A. Amato) Kathon C.G.: ri sk of sensitization (A.C. De Groot) Methods for evaluating initant - erylhematogenic activity in cosmetics (A. Se11oli, S. Gio1gini, C. Mrutinelli, M.C. Meli i) Socia! problems related to perspiration: the cosmetic connection (C. Jacobson) Barriers creams (L.C. Parish) Evaluation of a new skin barrier providing water and solvent protection (P. Morganti, S.D. Randazzo) Cosmetology and sexuality in the history of gynaecology (G. Forleo, M. Fraticelli) Metabolism of steroids in human skin (A. Lanzone, A.M. Fulghesu, F.P. Sellante, A. Caruso, S. Mancuso) The stucture and permeability of the oral mucosa (A. Jarret) Oral mucosa and dental care problems (E. Benagian) Vitamins and minerai nutrition in the skin (B. Berra, S. Zoppi, S. Rapelli) Good manufacturing and quality control practices in the cosmetic industry (F. Pocchiari) Cosmetology and public health (L.Toti)

400 pages about - Hard-bound Price: U.S. $ 90.,00 I in Italy L. 120.000

41

J. Appl Cosmetol. 9, X/X-XXIX (January- March 1991)

Announcement

IV INTERNATIONAL MEETING ON COSMETIC DERMATOLOGY

PROGRESS IN COSMETIC DERMATOLOGY: SCIENCE AND SAFETY

October 30 - November 2 , 1991 Villa MIANI • R O ME • ITALY

PRELIMINARYPROGRAM PROGRAMMA PRELIMINARE

OCTOBER 31 th THURSDAY I GIOVEDI' 31 OTTOBRE

09.00 - Generai co11sideratio11s I Considerazioni generali (C. Jacobson · U.S.A.) 09.30 · Ope11i11g remarks I Note introdutt ive (P. Morgami · I) 09.45 - Cosme1ic prepara1io11: slale of 1/re ari/ I prodotti cosmetici: stato dell 'ane 10.00- Safe1y e1·a/11atio11 of cosmelic illgrediellls i111he Europea11 Comm1111i1y a11d in 01/rer c011111ries I Valutazione della sicurezza degli ingredienti CO·

smctici nella CEE e negli alt ri paesi (N. Loprieno -1) 10.15 - Role of lipids in biologica/ membra11es I Ruolo dei lipidi nelle membrane biologiche (B. Berra ·O 10.30 - Adw111ces in perc111a11eo11s absorp1io11 / L'assorbimento percutaneo secondo le più recenti acquisizioni (W. Shalla - D) 10.45 · Liposomes:f11111re prospecls a11d a/1emative so/111io11s / I liposomi:prospettive future e soluzioni alternative (G.Gregoriades · U.K) 11.00 • Break 11.15 - Pedia1ric cosme1ology: c11rre111a11df11111re1re11ds I La cosmesi della prima età: oggi e domani (C. Jacobson · U.S.A.) 11.30 - Socia/ role <f rosmetics in elderly people I Ruolo sociale dei ro;metici nella terza età (A. Tosti -O 11.45 · Cosme1ic derma10/ogy a11d mucous 111e111bra11es I Cosmesi derniatologica e mucose (S. Mancuso - I) 12.00 · EEC cosme1ic i11gredie111s a11d labeli11g I L'etichettatura degli ingredienti cosmetici (De Giuli -O 12.15- Q11ali1y co111rol io pro1ec1 EEC co11s11111er /li controllo qualità a difesa del consumatore (L. Gagliardi - I) 13.00 - 8ru11c/1

SKIN SURFACE AND PERMEATION I CUTE E ASSORBIMENTO

14.00 • Liposomes as 11a111ra/-like 111e111bra11es / l liposomi quali membrane naturali simili 14. 15 - Liposomes as topic carriers: progress worki11g / l liposomi come carrier per uso topico: prospettive e realtà (G. Gregoriades. U.K.) 14.30 - F1111c1io11 a11d s1abiliry of liposomes as cosme1ic 1•ehicles I Funzione e stabilità dei liposomi come veicoli cosmetici (E. Menegani ·O 14.45 -New biodegradable a11d biocompa1ible capsules /or 1/re cosme1ic i11d11s1y: the collaspheres /Le nuove capsule biodegradabili e bio-

compatibili per l'industria cosmetica: le collasphere (A.Huc - F) 15.00 · Disc11ssio11 / Discussione 15.30 · The choice of 1•ehicles in cosmetic dermaw/ogy I L'imponanza dei veicoli nella dermatologia cosmetologica (B. James · U.S.A.) 15.45 - Activity of1•ehicles a11d diff11sio111hro11gh 1/re homy layer I Attività dei veicoli e loro diffusione attraverso lo strato corneo (\V. Shalla . D) 16.00- Ski11 pem1eabili1y in infa111s a11d yo1111g childre11 / Permeabilità cutanea nella prima infanzia e nella pubenà (C. Jacobson - U.S.A.) 16.15 - Ski11 pem1eabi/i1y in elderly peop/e I La perrneabililà cutanea nell 'anziano (F. Kerdel Vegas -YV)

16.30 - Permeability of buccal mucosa 111e111bra11es I La permeabilità della mucosa orale (A. Jarret. U.K.) 16.45 • Permeabiliry of vagina/ mucosa surfaces I Permeabilità ed assorbimento della membrana vaginale (S. Mancuso · I) 17.00 · Discussio11 / Discussione 17.15- Break

Announcement

ACTIVE COSMETIC COMPOUNDS FOR ELDERLY SKIN I PRINCIPI ATTIVI PER LA CUTE INVECCHIATA

17.30 - Phatophisiology of dry ski11a11d1reat111e111 / Patofisiologia e trattamento della cute secca (M. \V. Greaves - U.K.) 17.45 · Topica/ use of reti11oic acid i11 aged a11d stressed ski11 / L'uso topico dell'acido retinoico nella cute invecchiata (W. Raab. A) 18.00 · "Prolonged 1111d co111rolle1l release of cosmetic dermatologie actives with a s11b111icro11ic polymeric la11ice: 11a11ospheres 100•· /

Controllo e realizzazione dei principi attivi cosmetici con latice submicroscopico: nanosphere 100' (J. Caillon. F) 18.15 · Viw111i11 derirmes in aged ski11 / Le vitamine quali principi attivi per l'invecchiamento cutaneo (D. Djerassi - U.S.A.) 18.30 - Ef!ects of col/11ge11 011 ski11 surface I Gli effetti del collagene sulla cute invecchiata 18.45 · Disc11ssio11 /Discussione 20.30 • Be111•e1111e cocktail I Cocktail di benvenuto

NOVEMBER lst FRIDAY I VENERDI' 1 NOVEMBRE

COSMETIC PRESERVATION I LA CONSERVAZIONE DEI PRODOTTI COSMETICI

09.00 - The rote of preserratil'es i11 comrolling microbial co111a111i11atio11 i111roduced i11 the 111a111ifac111re of cosmetics I Contaminazione batterica e conser-vanti (E. F. W. Warwick · U.S.A.)

09.15 - Aspects 011 biocide use I Aspetti tecnici sull'uso dei conservanti (K. H. Diehl - D) 09.30 - Parabens today / I parabeni oggi (Kranbar - U.S.A.) 09.45 - Substitwed i111ida:olidi11yl urea com[Jo11111/s / lmidazolidinyl urea e derivati (W. E. Roses - U.S.A.) 10.00 · Food-grade i11gredie111s as presen•atil'es I Conservanti di grado alimentare (J. J. Kabara - U.S.A.) 10.30 - New [Jhospholipids as presen·atives: 011 update I L'uso dei fosfol ipidi come conservanti (J. I. Yablonski, D. Fost - U.S.A.) 10.45 - Skin irri1a1io11 a11d se11siri:mio11 caused by preserratires / Irritazioni e sensibilizzazioni provocate dai conservanti (K. E. Andersen - D) 11.00 - Toxicity of[Jresen·atires I La tossicità dei conservanti (H. F. Kemper. D) 11.15 - Discussio11 / Discussione 11.30 - Bnmch 13.00 ·Bus IO Casamari (fa111011s gothic dwrch) I Autobus per l'abbazia di Casamari

NOVEMBER 2nà SATURDAY I SABATO 2 NOVEMBRE

COSMETIC DISTRIBUTION I LA DISTRIBUZIONE DEI COSMETICI

09.15 - Legai i111p/ica1io11s of selectfre cha1111el distrib111io11 / Problemi giuridici connessi con la distribuzione di canali selettivi (F. Terenzi - 1) 09.30 · Cha1111eli11g distribwio11 of cosmetic producrs i11 /1a/y I La distribuzione dei cosmetici in Italia nei differenti canali (E. Chiaccherini - I) 09.45 · F.O.Fl. direcrion of phar;11acy cosmetic producrs I Orientamenti della F.O.F.l. sui problemi riguardanti il comparto "cosmetici in fannacia" (G. Leo-

pardi) 10.00 - ltalia11 Feder. Farma direcrions 011 dermocosmetics I Orientamenti della Feder. Farrna sul comparto derrnocosmetico (A. Ambreckt -1) 10.15 - Cosmetic market i11plwrmacy:a11a1io11a/ e11q11ire / Il mercato dermocosmetico in fannacia: indagine nazionale UTlFAR (L. Casanova- I) 10.30 - Pharmacy distrib111io11 of cosmetic products I La distribuzione dei cosmetici in famiacia (Magnanclli - 1) I 0.45 · Disc11ssio11 / Discussione 11.15-Break

LEGAL AND PROFESSIONAL RESPONSABILITIES RESPONSABILITÀ CIVILE E IMPLICAZIONI LEGALI

11.30 · Legal liability of cosmetic producers IO the public I L1 responsabilità civile del produttore di cosmetici (A. tannini . I) I I .45 - Legai liability of physicia11s as cosmetic [Jroducts [Jrescribers 10 the public I La responsabilità civile del medico quale prescrittore di cosmetici (M.

Rota Muscardin - O 12.00 - Legal liability of pharmacist as cosmetic producrs dealers to the public I L1 responsabilità civile del farmacista quale distributore (M. Marcheui . I) 12.15 - Misleadi11g and corree/ adverrising I Pubblicità ingannevole e pubblicità corretta (Masi · I) 12.30 · Low prorecrio11 of EEC co11s11111er /La tutela giuridica del consumatore europeo 12.45 - Diswssion I Discussione 13.15 - Bru11c/1 14.45 / I 8.00 - Free co1111111111ica1io11s I Comunicazioni libere

Announcement

FREE COMMUNICATIONS I COMUNICAZIONI LIBERE:

Abstract of works relared to the ma in topi es of the meeting can be s11b111i11ed 10 the Scientific Secretatriat be/ore July I 5, 1991. Abstract should be 111ri11en in English 011 the abstractform 111/zich is enc/osed to the preli111i11ary programme.

l lavori relativi agli argomenti principali del Convegno debbono essere inviati alla Segreteria Scientifica entro il 5 Luglio l 99 1. li testo del lavoro dovrà essere in inglese e redatto sull 'apposito modulo che accompagna il presente programma preli­minare.

INSCRIPTION FEES I TERMINI DI ISCRIZIONE:

Be/ore July 15th, 1991 i650.000 ltalian Lire -After July 15th, 1991i850.000 lta/ic111 Lire.

Entro il l 5 Luglio, 1991 Lit. 650.000 - Dopo il 15 Luglio, 199 1 Lit. 850.000.

ORGANIZING SECREIARIAT I SEGRITTERIA ORGANIZZATIVA

GIBI Studio Congressi Via Marco Besso, 40 · 00 191 - ROMA (llaly)

Tel. 06/32.73.291-32.86.478 Telefax: 06/32.76.288

SCIENTIFIC SECRETARIAT I SEGRETERIA SCIENTIFICA

lnternational Society of Cosmetic Dermafology Via Innocenzo Xl , 41 -00165 - ROMA (ltaly)

Tel. 06/63.78.788 Telefax: 06/63.80.839 Telex: 621100 (address)\\ KNM =

IV INTERNATIONAL MEETING ON COSMETIC DERMATOLOGY PROGRESS IN COSMETIC DERMATOLOGY: SCIENCE AND SAFETY

October 30 - November 2, 1991 - Villa MlANI - ROME - ITALY

MODULO DI PRENOTAZIONE ALBERGHIERA

li presente modulo, con il deposito richiesto, dovrà essere inviato al più presto a: GIBI Studio Congressi - Via Marco Besso, 40 - 00191 ROMA -Tel. (06) 3273291 - 3286478 - Fax 3276288

(prego compilare a macchina o in s1ampa1ello)

Cognome ....... ............. ......... . ................ . .. . ...... Nome ..................................... . .... .. .. .

Indirizzo ... . ... ....... ............. . ..... .. .... .. . ................. ...................... .................. . ... ....... .

c.a.p ......... ......... .... Città ..................... . .. ....... .. .... .... .. Tel. .. .. .. . ..... .. . ...... ... . .. . ..... . ... ..... .

Condizioni: - 1 prezzi si intendono per camera, per notte e includono la prima colazione o la mezza pensione - Tutte le camere hanno servizi privati - La richiesta di prenotazione dovrà pervenire il più presto possibile e dovrà essere accompagnata da un deposito pari al

costo della prima notte più Lit. 15.000 a camera per spese di prenotazione - Per eventuali cancellazioni che perverranno entro il 27 giugno '91 saranno addebitate le sole spese di prenotazione,

dopo tale data sarà addebitata anche la prima notte

Camera e piccola colazione Mezza pensione

O Hotel Hilton (! ' cat. lusso) O camera singola o 260.000 o 329.000 O camera doppia o 342.000 o 480.000 O camera doppia uso singola o 301.000 o 370.000

O Hotel Clodio (2' cat.) O camera doppia o 220.000 o 290.000 O camera doppia uso singola o 179.000 o 214.000

O Hotel Olympic (2' cat.) O camera singola o 170.000 O camera doppia o 210.000

Vi richiedo di prenotare n ..... camera( e) su specificata( e) con arrivo il giorno ......................... .... .. ..

e partenza il giorno ............ Allego il deposito della prima notte più Lit. 15.000 a camera a mezzo assegno

n ............................... della banca .................... per un importo di Lit. ........................ .

N.B. - Le camere singole sono in numero limitato e potranno essere assegnate solo alle prime prenotazioni.

Note ................ . ................................. .. ................................................ ... .. .

Data ................................... Firma ............................................................... .

IV INTERNATIONAL MEETING ON COSMETIC DERMATOLOGY PROGRESS IN COSMETIC DERMATOLOGY: SCIENCE AND SAFETY

October 30 - November 2 , 1991 - Villa MIANI - ROME - ITALY

HOTEL RESERVATION FORM

Please type or print using block letters and rerum to: GIBI Studio Congressi - Via Marco Besso, 40 - 00191 ROMA - Tel. (06) 3273291 - 3286478 - Fax 3276288

Sumame ......... . .. .. . . ..... .. ... ...... . .. .. . .. .. .... .. ..... .... Name .. ...... . ... .. .... . ...... .. ...... . .. ... . . .. .. . . .

Address ......... ......... .. ............. ... ........... . ... . ...... Country ................ . ........... .. .. .. ... . . ..... .

Zip code .......... .. .. ... City .. . ... . ..... . ................ . .. .. . . .. . ..... Tel.No . ... . . .. .. . .. . ..... ...... .. .. .. ... . .... .

Conditions: - Prices are per room, per night and include bed and breackfast or half board service - This reservation forni should reach GIBI Studio Congressi as soon as possible - First night deposit plus Lit. 15.000 as agency fee are required at the moment of reservation

The deposit will be deducted from the hotel bili upon departure - Request for cancellations must be received before July 27, 1991. For cancellations received before July 27 only the

agency fee will be charged. After this date also the first night deposi! will be charged

Bed and breakfast Half board O Hotel Hilton (I' cat. Luxory) O single room o 260.000 o 329.000 O double room o 342.000 o 480.000 O double room for single use o 301.000 o 370.000

O Hotel Clodio (2' cat.) O double room o 220.000 o 290.000 O double room for single use o 179.000 o 214.000

O Hotel Olympic (2' cat.) O single room o 170.000 O double room o 210.000

Please reserve n ........ .. ..... room(s) arrivai date ...... . .............. departure date ...... ... ........ .. ... .

I enclose first night deposi! plus Lit. 15.000 per room with check n .......... . . .. Bank .......... ...... .. ...... .

of Lit. .. . ...... . .......... . ................................................................. ..... ... . ... .. . .. .

N.B. - As single rooms are very few they will be assigned on first come, first served basis.

Note .................... . ........... . ........ . ........... .. ........ . ..... . .... . ............... . ...... .. .. .. . .. .

Date .. ..... . .... .. . . ...... . ..... . . . .... Signature ..... .. . . . .. ......... .. .. . ... .... .. . . ...... . .. . ....... ...... .

e

IV INTERNATIONAL MEETING ON COSMETIC DERMATOLOGY PROGRESS IN COSMETIC DERMATOLOGY: SCIENCE AND SAFETY

October 30 - November 2 , 1991 - Villa MIANI - ROME - ITALY

SCHEDA DI ISCRIZIONE

Cognome ................................................. . ...... Nome . .... . ....... . . .. ........ . .................... .

Indirizzo ................... . .. . .. .... ........ .......... .................. ......... ............... ...... . . .. .. . .. . ..... . (dell"in1es1a1ario della fanura)

c.a.p ....... .. .. . .. . .. .. .......... . ....... .. Città . ... . ..... .............. .. ... ... ........... .. ........ . ..... .... .. .. ... .

Telefono .. . ... . . ..... . ... . .. ..... .. .. .. .. . ......... .............. C.F. - P. IVA .. .. . . ..... .......... . . .. . .......... . ... . (dell'imesiaiario della fauura)

Quota di iscrizione: entro il 15 luglio Lit. 650.000 dopo il 15 luglio Lit. 850.000

La scheda con allegato assegno o vaglia postale intestato a G!Bl Studio Congressi, dovranno essere inviati alla Segreteria Organizzativa: GIBI Studio Congressi - Via Marco Besso, 40 - 00191 ROMA -Tel. (06) 3273291 - 3286478 - Fax 3276288

Allegato assegno/vaglia n . . . . ... .. ..... ... . . ... . .. .. .... . ...... . ...... della Banca .... . .... .. .. . .... .. .. . . . . ... .. . ...... .

di Lit. ........................ .. ....... . ........... . ..... . ..... . .. . ..... .. ..... ... .. .. .. .. ....... ... ........ ............. .

Data .......... . ... ...... ................... Firma ....... . . ..................... .. .................. . ........ ... . ........ .

IV INTERNATIONAL MEETING ON COSMETIC DERMATOLOGY PROGRESS IN COSMETIC DERMATOLOGY: SCIENCE AND SAFETY

October 30 - November 2 , 1991 - Villa MIANI - ROME - ITALY

REGISTRATION FORM

Sumame ..... . . . . ....... . .... ............. ..... ... ...... .. . . ..... Name ... ...... . ..... . . ........ . .. ........ . ........ . . .

Address ......... . .. ... .. ..... . .... .. .. . .. . ..... . .. . .. . .. . ........ . ..... . ... .... .. ........... .... .. . ..... . . .. ... .. . .... .

Zip Code ..... .. . . ......... ... .... .. .. ..... City . .. . . ... ........... .. ..... ....... .. ..... . .. . ....... .. .. . . .. ... ........ . .

Country . .. ... . .. .. ..... . . . .. .. . . ... .... ... ...... . ..... . ..... . ... ..... .... ... ..... . .................... : ...... .. . ...... .

Telephone No ...... . .......... . ........ . .. .. . .. .. ........ . ................. . ...... . ................. . ................. .

Registration fee: before July I 5 Lit. 650.000 after July I 5 Lit. 850.000

This form, duly filled in and signed, with check at the order of GIBI Studio Congressi, must be sent to the Organizating Secretariat: GIBI Studio Congressi - Via Marco Bessp, 40 - 00191 ROMA- Tel. (06) 3273291 - 3286478 -Fax 3276288

I enclose check n .......... .. ... . ..... .. . .. .. .. ........ . .... .... . .. .... Bank .. . ... . ........ ... ...... . .......... . .... ... .. .

of ltalian Lire ................. . ........ ................................................... ........................... . ... .

Date ........................... . ..... . ..... Signature ....... .................................. ........ .. . ......... ...... .

PROGRESS IN COSMETIC DERMATOLOGY: SCIENCE AND SAFETY Riassunto (solo in lingua Inglese) Abstract Reproduction Form (English language only) Trascrivere il riassunto nel rettangolo I Type abstract within the rectangle. Per ulteriori infonnazioni leggere le indicazioni sul retro I For further i11for111atioi1 see directio11s 01111ex1 page

Titolo Title

Autore A111hor

Riassunto Abstract _

Indicazioni I Directions

Titolo del lavoro - con lettere maiuscole. Title of paper - in capira/ lerrers.

Nome degli autori - in maiuscolo e minuscolo, con il nome del relatore sottol ineato. Name of author(s) - in up per and /ower case, with name of presenter 1111derlined.

Nome del dipartimento I ospedale I organizzazione I cittì1 - in maiuscolo e minuscolo. Name of department I hospita/ I organisatio11 / town I country - in upper and lower case .

Interi inea 2. Leave one line space.

Util izza una macchina da scrivere elettronica. Use an e/ectric typewriter with plastic b/ack ribbon only.

Il testo apparirà sul libro degli abstrnct come verrà inviato e g li eventuali errori rimarranno visibili . Your /ex/ will appear in the hook of abstracr exacrly as you sene/ it and every errar or impe1fec1ion will be visib/e.

Ultima data di ricevimento per il riassunto: 15 Luglio 1991 Deadline for receipt of abstract: July 15,1991

Rispedire il riassunto a: I Please retum the abstract to: P. Morganti, Via innocenza XI, 41 - 00165 Roma (ltaly)

NAME OF PRESENTER I NOME DEL RELATORE Nome/ Name -----------------------------------

Ospedale I Hospital -Organizzazione I Organisation

Indirizzo I Address

Città I Town -------------------- Nazione I Country

Telefono I Telephone ___________ Telex Telefax

I I I I I I I I I

i

Announcement

l SrH WORLD CONGRESS OF DERMATOLOGY Scholarships Available for the 18th World Congress of Dermatology

The 18th World Congress of Dermàtology will take piace in New York City from June l2-18, 1992. In an effort to encourage the participation of young dermatologists, the Congress will award a limited number of scholarships, as follows:

Dermatolo2ists from Developini: Countries: Applicants must be no older than 38 years of age at the time of the Congress. The scholarship will provide compl imentary registration and hotel accom­modations (two awardees to a room), and a moderate subsistence allowance. Awards are competi­tive and are contingent on sponsorship by one's national socie ty. Abstract submission is mandatory. Obtain further information and appl ication forms from your national society before June 1, 199 1 .

Dermatoloi:ists from Developed Countries: Applicant must be a Resident or Fellow in a full-time training program. The Scholarship will provide complimentary registration and a small subsistence a llowance. A letter from the educational or training insti tution va lidating the applicant 's status must be submitted with the application form. Abstract submission is mandatory.

Fonns are avai lable from the I 8th World Congress Secretari at, 875 Kings Highway, W. Deptford, NJ 08096, USA.

Cali for Abstracts for the 18th World Congress of Dermatology

The I 8th World Congress of Dem1atology Organizing Committee and the In ternational League of Dermatolog ica! Societies invite the subm iss ion of abstrac ts for short commun ications to be presented at the I 8th World Congress, June l2- I 8, 1992, New York City. Selected abstracts will be presented in the following sessions: - Case Presentations - Four-minute presentations of cl inica! cases of exceptional scientific and/or

educational i nterest. - Contributions to Clinica! and Experimental Dermatoloey

Q.rfil presentations of originai contributions of clinica!, therapeutic or laboratory investigations. Poster presentations of originai contributions to clinica! and laboratory investigation which can be effectively di splayed by ill ustrative materiai (graphs, charts and tables). Authors are to be present during specified times for discussion of the posted materia i.

Abstracts must be submitted on the officiai Congress Abstract Reproduction Form a nd received before August 1, 1991. Forms and submission guidelines are available from the 18th World Congress Secretariat, 875 Kings Highway, W. Deptford, NJ 08096, USA.

Chiuso in Tipografia: 22 Luglio 1991

Joumal of Applied Cosmctology published quartcrly by INTERNATIONAL EDIEMME, Via Innocenzo XI, 41, 00165 Roma Italy. Direttore responsabile P. Morganti. Direzione, Redazione cd Amministrazione Via Innocenzo XI, 00165 Roma Italy. Coordinamento all 'c~izionc P. Arcuri. Stampa Edigrafica Aldina s.r.l., Via della Massimilla 50, Roma, te!. 6692801-6693099. Progetto grafico cd impaginazione STYLOgrafica Roma. Spedizione in abbonamento postale gruppo IV (70. Aut. del Trib. di Roma n. 3173/83 dcli' 8-7-83.

MAVIGEN IDRO

SCHIUMA MAVIGEN IDROSCHIUMA

trova la sua specifica pre­

scrizione sopratutto per le

pelli grasse ed acneiche che

dopo i trattamenti farmaco­

logici con benzoi! perossi­

do, acido retinoico, antibioti­

ci o acido azelaico hanno bi­

sogno, in genere, di essere reidratate.

~ mav1

La ricerca scientifica nella dermocosmesi Mavì Sud S.r.l. - Viale dell'Industria, 1 - 04011 Aprilia (L T)

La giusta soluzione

Ml man

L ricerca scientifica nella dermoco~mesi Mavi Sud S.r.l. - Viale dell'Industria, 1 - 04011 Aprilia (L T)