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OIE Laboratory Twinning on Brucellosis Judy Stack Animal Health and Veterinary Laboratories Agency (AHVLA) United Kingdom Sevil Erdenlig Pendik Veterinary Control Institute (PVCI) Turkey OIE Reference Laboratory for Brucellosis

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OIE Laboratory Twinning on Brucellosis

Judy Stack Animal Health and Veterinary Laboratories Agency (AHVLA)

United Kingdom

Sevil Erdenlig Pendik Veterinary Control Institute (PVCI)

Turkey

OIE Reference Laboratory for Brucellosis

UK/Turkey Collaboration

Laboratory Twinning pairs:

Parent Laboratory: Animal Health & Veterinary Laboratories Agency (AHVLA)

OIE Reference Laboratory and FAO/WHO Collaborating Centre for Reference & Research on Brucellosis

Candidate Laboratory: Pendik Veterinary Control Institute (PVCI)

Established National Reference Laboratory for Brucellosis

Funded by World Organisation for Animal Health (OIE) for 3 years.Ensuring compliance with OIE guidelines for accurate diagnosis of disease.

OIE Laboratory Twinning:Aims

• Develop or enhance sustainable relationships• Exchange knowledge/technical guidance• Improve compliance with OIE standards• Promote safe working procedures and facilities• Support to region & eventually for candidates to apply for

‘reference’ status• Extend the OIE network of expertise geographically

Why Brucellosis?

• One of the worlds most significant zoonotic diseases in domestic livestock (and man)

• Spreads easily, despite vaccination, control is difficult & expensive

• Control programme essential – veterinary infrastructure - using validated laboratory tests

• Causes abortion and reduced milk production: economic/human impact

• Easily transmitted to humans causing potentially debilitating illness

• Potential BW agent - reportedly weaponised historically by several states

Hoover, D. L. & Friedlander, A. M. Brucellosis. In Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare

Why PVCI?

• Previous collaboration with UK group

• Brucellosis endemic area

• Experienced scientists - required specific training

• Build on existing capacity to work towards OIE stipulations

• Enhancing quality, biosafety & biosecurity

• Benefits for both institutes and ultimately global disease awareness

Project Objectives

Enhance the diagnostic capability of PVCI:

• Training in new methods/oversight of existing methods

• Prepare diagnostic standards according to OIE

• To apply molecular techniques to obtain more details on epidemiological situation

• Initiate a collection of material from infected animals for research and test validation

• Ensure harmonisation of testing between PVCI & AHVLA and introduce proficiency testing

Summary of Outputs

• Database of samples

• Turkish National Standards and reagents complying to OIE Standards in large volumes

• Harmonisation/ring trials/proficiency (for region and within Turkish diagnostic labs)

• Raised international profiles – presentations/meeting attendance

• Improved laboratory facility for safe and secure working at BSL3

• Molecular expertise and confidence

• Application for Turkish Commercial funding

• Future collaboration for both Institutes

Regional Workshop

Post twinning workshop hosted by PVCI:• Representatives from 11 states across Middle East and Central Asia.• Delegates from OIE, WHO, FAO and GP.

Aims:• To promote PVCI as a regional centre of expertise• To better understand regional brucellosis situation• To discuss regional approaches to surveillance

and control

Recommendations included: • PVCI and AHVLA working together to implement regional proficiency

testing (going ahead)• Approaches to surveillance/control should be harmonised across region• Acknowledging success - countries to consider requesting OIE Twinning

Sustainable Project Benefits for both

For Turkey:

• Scientists competent in internationally approved methods

• Accurate diagnosis of a disease of animal and public health concern

• Ability to reach out to organise proficiency testing – audits – ring trials

• Increased engagement with international scientific community

• Joint research opportunities (both)

• Working towards more regional engagement and OIE Reference Laboratory status

For UK:

• Increased awareness of international disease situation

• Access to material for maintenance of competence, test validation and research

• Career development opportunities for AHVLA scientists -communication, decision making, development of expertise etc.

Summary:Relevance to BTWC

• Example of contribution to fulfilling Article X obligations.

– Capacity building for detecting, reporting and responding to infectious disease outbreaks.

– Twinning programmes to develop human resources.

Laboratory Twinning is an excellent platform for strengthening cooperation and assistance between States Parties.

• Such projects also reduce vulnerabilities and strengthen the Convention by:

– Improving mechanisms for detecting, reporting and responding to outbreaks. – Enhancing biosafety and biosecurity.– Strengthening existing international organisations and networks working on

infectious disease.– Promoting transparency and peaceful use of dual-use skills and knowledge.

Further information:

Judy Stack, AHVLA [email protected]

Dr Sevil Erdenlig, [email protected]

OIE Reference Laboratory for Brucellosis