olea25® hydroxytyrosol neuroprotect cytoprotect
TRANSCRIPT
Olea25® Hydroxytyrosol
Olive Leaf Extract
Neuroprotective Support
Role of Neurodegenerative Prevention
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The Mediterranean Diet
Health Benefits
Lower mortality rate in countries around the Mediterranean Region.
Major ingredient of the Mediterranean Diet is the Olive and Olive Oil.
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Olea25®
Hydroxytyrosol
The Medicinal Value of the Olive Fruit and Leaf (Olea Europaea)
Medicinal and Nutritional Value
Extracts of Olive Leaf have been used for Promoting Health and Preservation for Millennia.
Polyphenol Hydroxytyrosol
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Olea25®
Hydroxytyrosol
● Antioxidant
● Anti-inflammatory
● Cardioprotective
● Antitumoral
● Antidiabetic
● Antimicrobial
● Neuroprotective
Health Promoting Properties of
Hydroxytyrosol
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Olea25®
Hydroxytyrosol
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Bioactive Polyphenol from
Olive Leaf Extract
Polyphenols: Neuroprotective Actions
David Vauzour, “Dietary Polyphenols as Modulators of Brain Functions: Biological
Actions and Molecular Mechanisms Underpinning Their Beneficial Effects,” Oxidative
Medicine and Cellular Longevity, vol. 2012, Article ID 914273, 16 pages, 2012. doi:10.1155
/2012/914273
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Modulation of Neuronal Dysfunction by Dietary
Polyphenols
Powerful Antioxidant
Hydroxytyrosol Strongest in vitro
Antioxidant potential
among all the Olive
Polyphenols
Visioli F, Bellomo G, Galli C.. Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun (1998)247(1):60–4.10.1006/bbrc.1998.8735
Olea25®
Hydroxytyrosol
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OLEA25® Hydroxytyrosol Fights 5 Free Radicals
Description: Olea25 Olive Leaf 25% Hydroxytyrosol Powdertrademark by Certified Nutraceutical, Inc (Certificate of Analysis).
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Olea25®
Hydroxytyrosol
Oxidative Stress ⇒ Disease
● Aging● Arteriosclerosis● Cancer● Neurodegenerative
Diseases○ Parkinson’s Disease(PD)○ Alzheimer’s Disease
(AD)
Antioxidant Capacity
15X higher than Green Tea
3X higher than CoQ10.
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Olea25® Hydroxytyrosol
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Antioxidant
Cancer
Diabetes Mellitus
NeurodegenerativeDisease
CardiovascularDisease
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Sources of Polyphenol-Hydroxytyrosol
(3,4-dihydroxyphenylethanol; DOPET)
Exogenous:
Ingestion of Natural Products that contain HT, or it’s precursors.
Endogenous:
Derived from Dopamine Oxidative Metabolism
Olea25®
Hydroxytyrosol
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Olea25®
Hydroxytyrosol
● Hydroxytyrosol Promotes the Cells Own Defenses Against Oxidative Stress
● Protects Neurogenesis
● Modulates Mitochondrial Function
Neuroprotective Support
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Olea25®
Hydroxytyrosol Imbalance between Reactive Oxygen Species (ROS) Production and Antioxidant Defense System
Neurodegenerative Disease
Causation
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Olea25®
Hydroxytyrosol
Alzheimer’s Disease
● Prevents Tau formation● Protects neuronal cells
against toxicity● Prevents Pro-Inflammatory
Cytokines & Immunological Mediators
Reversing Neurodegenerative
Disease
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Olea25®
Hydroxytyrosol
● Improved synaptic plasticity
● Down regulates inflammatory activity
● Increases Glutathione “brain antioxidant”
Crosses Blood-Brain Barrier
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Olea25®
Hydroxytyrosol
Resistance of Cellular DNA Damage
● Resists Brain Cell Oxidative Stress
● Protects Neuronal Cells
Cytoprotective Effects
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Olea25®
Hydroxytyrosol
Attenuates Toxicity
● ROS● Nitric oxide
overproduction● ↓ mitochondrial
membrane potential● ↓ cellular peroxide
formation
Cytoprotective Effects
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Olea25®
Hydroxytyrosol ● Mediated by
reduction if oxidative & nitrosative stress
● Reduction in pro-inflammatory interleukin levels
Cytoprotective Mechanisms
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Olea25®
Hydroxytyrosol
● Direct Scavenging ROS generated during oxidative stress
● Activates Cellular Signaling Pathways
● Induction of Phase II Detoxifying Enzymes via NrF2 Activation
BiotransformationAntioxidant Properties
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Olea25®
Hydroxytyrosol
● Activates NrF2 in tissue beneficial in neurodegenerative disease
● Increases activity of 3 Glutathione related enzymes
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Mitochondria Protective
Learn More
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Scientific-based nutraceutical for your clients.
Olive Leaf extract utilizing botanical extraction technology
Olea25™ is manufactured under GMP and ISO Certifications and the quality control system guarantees each item on the certificate of analysis and the traceability from raw material to final extract.
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Olea25®
Hydroxytyrosol
Olea25®
Hydroxytyrosol
Applications of Olea25
Hydroxytyrosol
● Nutraceutical
● Skincare
● Beverage
● Functional Foods
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Olea25®
Hydroxytyrosol
Distributor and Wholesale Interest: CLICK HERE
● Medical Professional
● Health Care Practitioner
Provide Contact Information Click Here
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Olea25®
Hydroxytyrosol
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Contact Information
Randy Bauer
bauerhealthaction.com
877-925-8444
Hydroxytyrosol
REFERENCES:
Visioli F, Bellomo G, Galli C.. Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys Res Commun (1998)247(1):60–4.10.1006/bbrc.1998.8735
Feng, Zhihui et al. "Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: regulatory effects of hydroxytyrosol." Free Radical Biology and Medicine 50.10 (2011): 1437-1446.
Schaffer, Sebastian, and Barry Halliwell. "Comment on hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction." Journal of agricultural and food chemistry 59.19 (2011): 10770-10771.
Hashimoto, Tsuneichi, et al. "An endogenous metabolite of
dopamine, 3, 4-dihydroxyphenylethanol, acts as a unique
cytoprotective agent against oxidative stress-induced injury." Free Radical Biology and Medicine 36.5 (2004): 555-564.
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Olea25®
Hydroxytyrosol
REFERENCES:
Munoz-Marin, Javier, et al. "Cytoprotective effect of hydroxytyrosyl alkyl ether derivatives after oral administration to rats in a model of glucose–oxygen deprivation in brain slices." Journal of agricultural and food chemistry 60.31 (2012): 7659-7664.
Farr, Susan A., et al. "Extra virgin olive oil improves learning and memory in SAMP8 mice." Journal of Alzheimer's Disease 28.1 (2012): 81-92.
Zheng, Adi, et al. "Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring." The Journal of nutritional biochemistry 26.2 (2015): 190-199.
Rafehi, Haloom et al. "Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis." Genes & nutrition 7.2 (2012): 343-355.
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Olea25®