OMX

In 1908, Ellie Metchnikoff a nobel laureate working at the Pasteur Institute, discovered that ingestion of certain microorganism can displace putrefactive toxin- producing bacteria… thus preventing (and even treating) diseases, thereby prolonging life and promoting health… (this was noted among Bulgarian farmers)

In 1908, Ellie Metchnikoff a nobel laureate working at the Pasteur Institute, discovered that ingestion of certain microorganism can displace putrefactive toxin- producing bacteria… thus preventing (and even treating) diseases, thereby prolonging life and promoting health… (this was noted among Bulgarian farmers)

For the last 20 years, Dr. Iichiroh Ohhira a Japanese Microbiologist, awarded Scientist of the Year in 1991 after successfully encapsulating strains of good bacteria as “Probiotics”.

For the last 20 years, Dr. Iichiroh Ohhira a Japanese Microbiologist, awarded Scientist of the Year in 1991 after successfully encapsulating strains of good bacteria as “Probiotics”.

is a LIVE microbial food is a LIVE microbial food medicine which beneficially medicine which beneficially improves and maintain human improves and maintain human intestinal microbial balance.intestinal microbial balance.

is a LIVE microbial food is a LIVE microbial food medicine which beneficially medicine which beneficially improves and maintain human improves and maintain human intestinal microbial balance.intestinal microbial balance.

Definition by the FAO/WHO Definition by the FAO/WHO “ “live microorganisms which when live microorganisms which when consumed in ADEQUATE consumed in ADEQUATE AMOUNTS, confer a health effect AMOUNTS, confer a health effect on the host.on the host.

Definition by the FAO/WHO Definition by the FAO/WHO “ “live microorganisms which when live microorganisms which when consumed in ADEQUATE consumed in ADEQUATE AMOUNTS, confer a health effect AMOUNTS, confer a health effect on the host.on the host.

pro fou nd ly d is tu rb s thein tes tina l ecosys tem

R eferences:1. C olo mb e JF e t al. La ncet. 19872. Vanderhoof JA et al. J Ped iatr. 1 9993. G oodm an & G illm an . Pharmacolo gical B asis of Therapeutics

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Effect of OMX capsule on Diarrhea in infants 3-24 months of age

JRRMMC

Randomized controlled trial. (2 Capsules a day)

Intake of OMX Probiotics capsule (1capsule BID for 5 days), in addition to ORS, significantly reduced the duration ofDiarrhea in children compared with those who only received ORS. The mean days Were shorter 3.17 days in the probioticGroup than in the non-probiotic group with 5.42 days.

Design

Outcome

* Second Prize; PPS – Inter-subspecialty Convention * Second Prize; PPS – Inter-subspecialty Convention 2006, Manila2006, Manila

Presented: 1Presented: 1st st Asian Congress of Pediatric Research Asian Congress of Pediatric Research Tokyo, Japan 2006Tokyo, Japan 2006

DesignDesign

OutcomeOutcome

Effect of Effect of OMXOMX capsule as Adjunct in the treatment of capsule as Adjunct in the treatment of Severe PneumoniaSevere Pneumonia in infants 6-24 months Of age in infants 6-24 months Of age

JRRMMCJRRMMC

Randomized controlled trial Group 1 ampicillin & probioticsRandomized controlled trial Group 1 ampicillin & probioticsGroup 2 probiotics only. (2 Capsules a day)Group 2 probiotics only. (2 Capsules a day)

Intake of Intake of OMXOMX Probiotics capsule Significantly shortened the duration Probiotics capsule Significantly shortened the duration of Illness (cough, fever, rales, retractions, Wheezing), hospital stay of Illness (cough, fever, rales, retractions, Wheezing), hospital stay and respiratory Symptoms with mean of 2.4 days in the Treatment and respiratory Symptoms with mean of 2.4 days in the Treatment group vs. 4.3 days in the control Group. Increase of appetite was also group vs. 4.3 days in the control Group. Increase of appetite was also observed.observed.

*First Prize; PPS – Inter-subspecialty Convention*First Prize; PPS – Inter-subspecialty Convention2006, Manila2006, Manila

Presented: 3Presented: 3rdrd Asian Congress Pediatric Infectious Asian Congress Pediatric Infectious Disease, Bangkok, Thailand Disease, Bangkok, Thailand

20062006 13 13thth Pediatric Infectious Disease Society Pediatric Infectious Disease Societyof the Philippines, Cebu, 2006of the Philippines, Cebu, 2006

Beneficial effects of probiotics, Beneficial effects of probiotics, OMX OMX capsule in capsule in Grade II Dengue Hemorrhagic FeverGrade II Dengue Hemorrhagic Fever

PCMCPCMC

Randomized controlled trial Open label. (2 Capsules a day)Randomized controlled trial Open label. (2 Capsules a day)

Intake of Intake of OMXOMX Probiotics capsule shows that patient did not Probiotics capsule shows that patient did not progress to further deterioration of their condition and were able to progress to further deterioration of their condition and were able to have earlier normalization of their hematocrit and platelet count. have earlier normalization of their hematocrit and platelet count. HCT 3.94 (control group) & 2.16 days (experimental group). HCT 3.94 (control group) & 2.16 days (experimental group). Platelet Count 5.50 (control group) & 3.3 Days (experimental Platelet Count 5.50 (control group) & 3.3 Days (experimental group).group).

DesignDesign

OutcomeOutcome

Presented: 2Presented: 2nd nd Congress of Asian Pediatric Research, Congress of Asian Pediatric Research, Yokohama, Japan 2007Yokohama, Japan 2007

Presented: 25Presented: 25thth International Congress of Pediatrics International Congress of PediatricsAthens, Greece 2007Athens, Greece 2007

Effect of OMX Probiotic capsule on Immune Markers of Undernourished Filipino Children

PCMC

Randomized controlled trial Open label. (2 Capsules a day)

Probiotics lead to significant weight gain (1 kilogram for the first week) and shorter duration of infections. Increase of appetite was also noted.

Design

Outcome

Effect of OMX, as adjunct treatment in Febrile Neutropenia among children 2 – 18 years of age.

CSMC

Double Blind Placebo Controlled Clinical Trial.

OMX produced clinical reduction in mean body temperature, shorter duration of hospital stay and significantly increase in ANC count. Increase Appetite also was noted. With resolved cases of UTI, mucositis and diarrhea.

Design

Outcome

* First Prize; 1.) CSMC Research Contest, 2008* First Prize; 1.) CSMC Research Contest, 2008 2.) PSH&BT, September, 20082.) PSH&BT, September, 2008

Presented: Pediatric Academic Societies & 4Presented: Pediatric Academic Societies & 4thth ASPR, ASPR, Honolulu, Hawaii, USA, 2009Honolulu, Hawaii, USA, 2009

OMX in the prevention of recurrent UTI in children with Urinary Tract Abnormalities

PCMC

Randomized Controlled Trial.

OMX Probiotics prophylaxis was a s effective as antibiotic prophylaxis in children with urinary tract abnormalities; increase appetite was also noted.

Design

Outcome

* First Prize; 1.) PCMC - Research Contest, 2009* First Prize; 1.) PCMC - Research Contest, 2009 2.) PPS – Research Contest, April, 20092.) PPS – Research Contest, April, 2009

Presented: Pediatric Academic Societies, 2009Presented: Pediatric Academic Societies, 2009 Baltimore, Maryland, USA Baltimore, Maryland, USA

The freeze drying process involves the removal of water The freeze drying process involves the removal of water by subjecting the bacteria to extremes of heat and cold by subjecting the bacteria to extremes of heat and cold

and the application of vacuum. This drastic “ripping off” and the application of vacuum. This drastic “ripping off” of water from a living organism disrupts its structure, of water from a living organism disrupts its structure,

function and internal environment.function and internal environment.

The freeze drying process involves the removal of water The freeze drying process involves the removal of water by subjecting the bacteria to extremes of heat and cold by subjecting the bacteria to extremes of heat and cold

and the application of vacuum. This drastic “ripping off” and the application of vacuum. This drastic “ripping off” of water from a living organism disrupts its structure, of water from a living organism disrupts its structure,

function and internal environment.function and internal environment.

• Addition of stabilizers and preservatives prior to freeze drying.Addition of stabilizers and preservatives prior to freeze drying.• Severe bacterial cell damage occurs if centrifugation and chemicals are used.Severe bacterial cell damage occurs if centrifugation and chemicals are used.• Extensive damage to bacteria caused by freeze drying process.Extensive damage to bacteria caused by freeze drying process.• Powder shelf life is short.Powder shelf life is short.• Powder absorbs water, then bacteria become activated and die away.Powder absorbs water, then bacteria become activated and die away.• Live bacteria in the powder have damaged walls and cannot grow properly.Live bacteria in the powder have damaged walls and cannot grow properly.• Transport and storage is easier, but must be refrigerated.Transport and storage is easier, but must be refrigerated.

• Addition of stabilizers and preservatives prior to freeze drying.Addition of stabilizers and preservatives prior to freeze drying.• Severe bacterial cell damage occurs if centrifugation and chemicals are used.Severe bacterial cell damage occurs if centrifugation and chemicals are used.• Extensive damage to bacteria caused by freeze drying process.Extensive damage to bacteria caused by freeze drying process.• Powder shelf life is short.Powder shelf life is short.• Powder absorbs water, then bacteria become activated and die away.Powder absorbs water, then bacteria become activated and die away.• Live bacteria in the powder have damaged walls and cannot grow properly.Live bacteria in the powder have damaged walls and cannot grow properly.• Transport and storage is easier, but must be refrigerated.Transport and storage is easier, but must be refrigerated.

POWDERSPOWDERSPOWDERSPOWDERS(free powders and capsules)(free powders and capsules)(free powders and capsules)(free powders and capsules)

LIQUID PREPARATIONS LIQUID PREPARATIONS (Yoghurt, etc.)(Yoghurt, etc.)

LIQUID PREPARATIONS LIQUID PREPARATIONS (Yoghurt, etc.)(Yoghurt, etc.)

Liquid preparations offer major disadvantages which relate Liquid preparations offer major disadvantages which relate to the instability of free organisms while in solution, harsh to the instability of free organisms while in solution, harsh

methods of preparation such as pasteurization, and the methods of preparation such as pasteurization, and the corrosive action of the stomach’s acid.corrosive action of the stomach’s acid.

Liquid preparations offer major disadvantages which relate Liquid preparations offer major disadvantages which relate to the instability of free organisms while in solution, harsh to the instability of free organisms while in solution, harsh

methods of preparation such as pasteurization, and the methods of preparation such as pasteurization, and the corrosive action of the stomach’s acid.corrosive action of the stomach’s acid.

• Short shelf life (few organisms remain alive in solution after several weeks)Short shelf life (few organisms remain alive in solution after several weeks)• Friendly bacteria damaged by pasteurization Friendly bacteria damaged by pasteurization (exposure to high temperatures 60 to 80 deg. C)(exposure to high temperatures 60 to 80 deg. C)• Severe bacterial cell damage occurs if centrifugation and chemicals are used.Severe bacterial cell damage occurs if centrifugation and chemicals are used.• Additives and preservatives are added to stabilize the bacteria in solution.Additives and preservatives are added to stabilize the bacteria in solution.• Transport and storage is difficult.Transport and storage is difficult.• Not suitable for overseas travel. Not suitable for overseas travel.

• Short shelf life (few organisms remain alive in solution after several weeks)Short shelf life (few organisms remain alive in solution after several weeks)• Friendly bacteria damaged by pasteurization Friendly bacteria damaged by pasteurization (exposure to high temperatures 60 to 80 deg. C)(exposure to high temperatures 60 to 80 deg. C)• Severe bacterial cell damage occurs if centrifugation and chemicals are used.Severe bacterial cell damage occurs if centrifugation and chemicals are used.• Additives and preservatives are added to stabilize the bacteria in solution.Additives and preservatives are added to stabilize the bacteria in solution.• Transport and storage is difficult.Transport and storage is difficult.• Not suitable for overseas travel. Not suitable for overseas travel.

FERMENTED PASTE FERMENTED PASTE CONTAINING CONTAINING

FRIENDLY BACTERIAFRIENDLY BACTERIA

FERMENTED PASTE FERMENTED PASTE CONTAINING CONTAINING

FRIENDLY BACTERIAFRIENDLY BACTERIA

The preparation of OM-X involves the use of natural The preparation of OM-X involves the use of natural organic ingredients and a natural non-chemical organic ingredients and a natural non-chemical

fermentation process unlike any other preparation fermentation process unlike any other preparation process currently used by industry.process currently used by industry.

- Bacteria-functional and viable.- Bacteria-functional and viable. - No damage to bacterial cell wall.- No damage to bacterial cell wall. - No centrifugation.- No centrifugation. - No freezing.- No freezing. - Storage and transport is easy.- Storage and transport is easy. - No preservatives and additives.- No preservatives and additives.

- Bacteria-functional and viable.- Bacteria-functional and viable. - No damage to bacterial cell wall.- No damage to bacterial cell wall. - No centrifugation.- No centrifugation. - No freezing.- No freezing. - Storage and transport is easy.- Storage and transport is easy. - No preservatives and additives.- No preservatives and additives.

If antibiotics were the If antibiotics were the Medicine in the 20Medicine in the 20thth century, century,

Probiotics will be the Probiotics will be the Medicine in the 21Medicine in the 21stst century. century.

““Don’t just save lives,Don’t just save lives,restore good health…”restore good health…”

““Let OHHIRA-OMX ProbioticsLet OHHIRA-OMX Probiotics be your partner in care…”be your partner in care…”

If antibiotics were the If antibiotics were the Medicine in the 20Medicine in the 20thth century, century,

Probiotics will be the Probiotics will be the Medicine in the 21Medicine in the 21stst century. century.

““Don’t just save lives,Don’t just save lives,restore good health…”restore good health…”

““Let OHHIRA-OMX ProbioticsLet OHHIRA-OMX Probiotics be your partner in care…”be your partner in care…”

Luisito L. Ruiz, M.D., FICS

Medical Director

Luisito L. Ruiz, M.D., FICS

Medical Director

South Star DrugM apagk ak a tiw a laang Tunay!

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GENERICA PHARMACY