oncology - pancreatic ca
TRANSCRIPT
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232 ., 227 . 14900 , 14100 . 50 . - 0,97; 5- 3,8% 4,6% , - 5-20%.
, . .
30 .
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(, )
10% ( ,
-, -, BRCA2, ).
Kras p53 .
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, .
, , , , .
, , 40 , 3,3 (95% CI:1,388,1). 2 , 15
. () .
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-75%
-18%
-7%
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6 :
-
( ) ( )
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:
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( )
:
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0
1 , 2 .
2 , 2 .
3 12-., , ( , ,
, ( , , , , )
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Nx
N0
N1
N1a
N1b /
0
1
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1.
- - - - ()
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2. 3. 4. 5. -
6. - - -
7. 8.
9.
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1.
2.
3.
4.
5.
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1. , .
2. . .
3. .
4. ( ) 70-80%.
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().
CA-19-9 (sialyl-Lewis-aantigen), .
. ().
().
().
. .
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.
. .
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.
.
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- ( )
-- : , , .
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12 . (W. Molnar, A.E.Stockum, 1974 .)
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)
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)
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. .
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,
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, .
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- , .
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1
3
,
4
2 -
6
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5
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. .. , ..
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.
, .
81%.
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5- ( 750,1000, 1250, 1500 mg/m2). 7 12.8 .
(Gem+FU+LV) 11
. 21 . (Pister et al., 2003). 4 ., - 7-8 ., 1 .
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36% 19% - 2 .
3 25% , 50%, 10 . 1- 3 59% 21%, 11% 4 .
4% 1 .