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Improving  the  Research  Portfolio  Data  Infrastructure  at  NIH

Modeling   Science,   Technology  &  InnovationWashington  DCMay  17-­‐18,  2016

James  Onken,  Ph.D.,  MPHDirector,  Office   of  Data  Analysis  Tools  and  Systems

NIH  Office   of   Extramural  Research

Public  accountability  and  leadership  are  key  aspects  of  NIH’s  stewardship  of  the  biomedical  enterprise…[C]urrent deficiencies  in  information  management  methods  and  infrastructure to  collect,  analyze,  and  report  level-­‐of-­‐investment  data  in  a  timely  fashion  need  to  be  addressed…NIH  must  also  improve  its  tracking  and  analysis   of  the  research  accomplishments  of  scientists  trained  and  supported  with  NIH  funds.

Committee  on  the  Organizational  Structure  of  the  National  Institutes  of  HealthNational  Research  Council

http://www.nap.edu/catalog/107769.htm  

National  Research  CouncilJuly  2003

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Need  for  Data  Integration“NIH  administrative  staff  have  had  limited  tools  to  retrieve,  analyze,  and  report  the  results  of  the  NIH  collective  investment  in  biomedical  research…  A  better  way  would  be  a  more  facile,  integrated  analysis  and  reporting  tool  for  use  across  the  NIH  by  administrative  leadership  and  program  staff.  This  tool  (or  these  tools)  would  take  advantage  of  recent  informatics  capabilities.”

August  2012NIH  Advisory  Committee  to  the  Director,  Data  and  Informatics  Working  Group

http://acd.od.nih.gov/Data  and  Informatics  Working  Group  Report.pdf

“NIH  should   link  its  own  data  infrastructure  with  that  of  its  many  partners  in  the  science  and  health  ecosystems  who  are  already  tracking  many  outcomes  of  interest  to  NIH  (e.g.,  CDC,  U.S.  Patent  and  Trademark  Office,  Food  and  Drug  Administration).”

March  2014NIH  Scientific  Management  Review  Board

Working  Group  on  Approaches  to  Assess  the  Value  of  Biomedical  Research  Supported  by  NIHhttp://smrb.od.nih.gov/documents/reports/VOBR-­‐Report-­‐122013.pdf  

“Measures  of  research  activities,  outputs,  and  technology  transfer  are  important,and  both  the  measures  and  the  underlying  data  need  to  be  improved.    [NIH  Data]  would  be  more  valuable  if  its  data  had  more  complete  coverage,  were linked  to  other  data  sources,  and  were  made  more  accessible  to  researchers.”

June  2014NRC  Committee  on  Assessing  the  Value  of  Research  in  Advancing  National  Goals

http://nap.edu/catalog.php?record_id=18804  

Use  CaseMining  Patents   for  Government  Interest…

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In  1993-­‐1994  alone,  1890  patents  cited  discoveries  made  by  NIGMS  grantees…  14  percent of  all  U.S.  patents  for  drugs  and  medicines  in  1994  cited  NIGMS-­‐supported  papers.  Further,   the  number  of  NIGMS  citations  is  the  second  highest  of  all  the   Institutes  at  NIH,  and  it  is  the  fifth  highest  when  measured  against  all  organizations,  including  all  private  organizations.  

…  Again

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Direct  CitationSemantic  Annotation:

• Investigator  Names• Organizations• Products• Technologies• Diseases• Areas  of  Research• Relationships

Text  Similarity

Grants   Administration

Linking  Data  in  PARDI

May  18,  2016            5

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PARDI  v1.0  System  Architecture

PaaS

RDF  Server(Neo4j)

PARDIData   Warehouse

(PostgreSQL  &  Red  Hat   Enterprise  Linux  )

Local  Server

Clinical  Guidelines

Clinical  Trials

Web  of  Science/iCite

FDA  Orange  Book

FDA  Purple  Book

Patents/iTech

ETL

IRDB  (Oracle)

User  Interface

User  Interface

April   28,  2016   20

Use  CaseThe  Development   of  Gardasil

May  18,  2016            7

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Linked  to  NIH  Funding

ReTRACEResearch  Timeline  Reporting,  Analysis,  and  Curation  Environment

April   28,  2016   9

ReTRACE Network

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Cure  Network  Informatics

R.  Sanders  Williams,  Samad Lotia,  Alisha  K.  Holloway,  Alexander  R.  Pico.  From  Scientific  Discovery  to  Cures:  Bright  Stars  within  a  Galaxy.  Cell,  2015;  163  (1):  21  DOI:  10.1016/j.cell.2015.09.007

May  18,  2016            9

Cited   References

NIH  Supported  InstitutionsNIH  

Grants

Foundational  Publications

Clinical  Tr ials

Repatha

Repatha Network

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NIH  ExPORTERhttps://ExPORTER.nih.gov

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Federal  RePORTERhttps://FederalRePORTER.nih.gov

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• NIH• NSF• EPA• USDA  (USFS,  ARS,  NIFA)• ACF• AHRQ

• CDC• DOD  (CNRM,  CDMRP,  DVBIC)• FDA• NIDILRR• NASA• VA

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Federal  RePORTERProject  Descriptions

May  18,  2016            14

Federal  RePORTERResults

May  18,  2016            15

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Federal  ExPORTER

May  18,  2016            16

April   13,  2016              18

World  RePORThttps://WorldRePORT.nih.gov

Redesign  Summer  2016Funding:  

• NIH• MRC• BMGF• EU• CIHR

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Acknowledgements

NIH  PARDI  Working  Group

NETE  Solutions

Science  and  Technology  Policy  Institute

NIH  OD  Sponsors  and  CollaboratorsDPCPSI  Office   of   Portfolio  Analysis  (George  Santangelo)OER  Office   of  Planning,  Analysis,  and  Communication  (Luci   Roberts)OER  Office   of  Research  Information   Systems  (Rick  Ikeda)OSP  Office   of   Science  Management  and  Reporting  (Marina  Volkov)

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THANK  YOU

NOTES:

James  Onken,  Ph.D.,  MPH,  Director,  OER  DATA  Systems    (James.Onken@nih.gov)Brian  Haugen,  Ph.D.  Health  Science  Policy  Analyst  (Brian.Haugen@nih.gov)

Cindy  Danielson,  Ph.D.,  Health  Science  Policy  Analyst  (Cindy.Danielson@nih.gov)  

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