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Optimal Timing of Preoperative Radiation for Prophylaxis Against Heterotopic Ossification by Mustasim N. Rumi, Gurvinder S. Deol, Jason A. Bergandi, Kishor P. Singapuri, and Vincent D. Pellegrini J Bone Joint Surg Am Volume 87(2):366-373 February 1, 2005 ©2005 by The Journal of Bone and Joint Surgery, Inc.

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Page 1: Optimal Timing of Preoperative Radiation for Prophylaxis Against Heterotopic Ossification by Mustasim N. Rumi, Gurvinder S. Deol, Jason A. Bergandi, Kishor

Optimal Timing of Preoperative Radiation for Prophylaxis Against Heterotopic Ossification

by Mustasim N. Rumi, Gurvinder S. Deol, Jason A. Bergandi, Kishor P. Singapuri, and Vincent D. Pellegrini

J Bone Joint Surg AmVolume 87(2):366-373

February 1, 2005

©2005 by The Journal of Bone and Joint Surgery, Inc.

Page 2: Optimal Timing of Preoperative Radiation for Prophylaxis Against Heterotopic Ossification by Mustasim N. Rumi, Gurvinder S. Deol, Jason A. Bergandi, Kishor

Modification of the scale described by Brooker et al.32 for grading heterotopic ossification in rabbits.

Mustasim N. Rumi et al. J Bone Joint Surg Am 2005;87:366-373

©2005 by The Journal of Bone and Joint Surgery, Inc.

Page 3: Optimal Timing of Preoperative Radiation for Prophylaxis Against Heterotopic Ossification by Mustasim N. Rumi, Gurvinder S. Deol, Jason A. Bergandi, Kishor

The radiation field included the hip joint, trochanters, and abductor muscles.

Mustasim N. Rumi et al. J Bone Joint Surg Am 2005;87:366-373

©2005 by The Journal of Bone and Joint Surgery, Inc.

Page 4: Optimal Timing of Preoperative Radiation for Prophylaxis Against Heterotopic Ossification by Mustasim N. Rumi, Gurvinder S. Deol, Jason A. Bergandi, Kishor

Irradiation at twenty-four hours prior to the operation was the most effective for prophylaxis against heterotopic ossification.

Mustasim N. Rumi et al. J Bone Joint Surg Am 2005;87:366-373

©2005 by The Journal of Bone and Joint Surgery, Inc.

Page 5: Optimal Timing of Preoperative Radiation for Prophylaxis Against Heterotopic Ossification by Mustasim N. Rumi, Gurvinder S. Deol, Jason A. Bergandi, Kishor

Comparison of a hip in the twenty-four-hour group (left, with grade-0 heterotopic ossification) with one in the seventy-two-hour group (right, with grade-III heterotopic ossification)

demonstrates superior efficacy of the radiation administered twenty-four ...

Mustasim N. Rumi et al. J Bone Joint Surg Am 2005;87:366-373

©2005 by The Journal of Bone and Joint Surgery, Inc.