option h: gas exchange
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OPTION H: Gas exchange. Unit 1. Energy Production and Transport. Mechanism of Oxygen Transport in the Human Body. Oxygen dissociation curves .-. Hemoglobin is an oxygen transport protein in the blood. - PowerPoint PPT PresentationTRANSCRIPT
OPTION H: Gas exchange
Unit 1. Energy Production and Transport
Mechanism of Oxygen Transport in the Human Body
Oxygen dissociation curves.-Hemoglobin is an oxygen transport protein in the
blood.
The degree to which oxygen binds to hemoglobin (oxygen saturation) is determined by the partial pressure of Oxygen (PO2)
Partial pressure is the total pressure of a mixture of gases within which a gas occurs, multiplied by the percentage of the total volume the gas occupies. It is measured in mm Hg or KPa (kilopascals).
The dissociation curves illustrate the behavior of hemoglobin during loading and unloading of oxygen.
The shape of the curve can be explained by the changing affinity that each hemoglobin molecule has for oxygen as it becomes saturated with oxygen.
At low PO2, such as what occurs in muscles, O2 will dissociate (unload) from hemoglobin.
At high PO2, as occurs in the lungs, the hemoglobin will become saturated (loaded).
Oxygen Saturation Curve
Bohr ShiftIncreased metabolism = greater release of CO2 into the blood lower pH of blood.
Increased acidity shifts the oxygen dissociation curve to the right greater release of oxygen from hemoglobin at the same partial pressure of oxygen.
This is known as the Bohr shift.
Bohr ShiftEnsures that respiring
tissues have enough oxygen when their need for oxygen is greatest.
Also in the lungs, if PO2 is lower, saturation of hemoglobin can occur at lower partial pressures of oxygen.
MyoglobinMyoglobin is a specialized oxygen
transport protein in muscles.It has a much higher affinity for
oxygen and will only release its oxygen when the PO2 is quite low, for example in muscles during heavy exercise.
While hemoglobin has four chains with four heme groups, myoglobin has only one heme group.
The release of each O2 from myoglobin triggers a conformational change, which cause the hemoglobin to more rapidly release subsequent O2 molecules.
Fetal HemoglobinFetal hemoglobin has a higher
affinity for O2 at all partial pressures.
This ensures that O2 is transferred to the fetus from the maternal blood across the placenta.
The PO2 in fetal tissues is very low due to the high metabolic rate associated with fetal growth rates.
Although fetal Hb has a higher affinity for oxygen in such a low partial pressure environment of the fetal tissue it unloads oxygen readily.
At birth the foetal Hb is replaced with adult type Hb.
Exercise and Ventilationa) Exercise increases metabolism and
leads to an increase in the production of CO2. Increased CO2 causes blood pH to decrease as it forms carbonic acid (H2CO3)
b) c) Chemoreceptors in the aorta and the carotid artery are able to detect a change in blood pH. If a drop in pH is detected, the chemoreceptors send a message to the breathing center of the medulla oblongata.
d) The cardiac center responds to the same stimuli and increases heart rate
e) Nerve impulses are sent from the medulla to the diaphragm and the intercostals muscles causing them to increase the ventilation rate (e). This leads to an increased rate of gas exchange. The long-term effect of exercise is increased lung surface area.
Time to work on the DBQ
Gas exchange at high altitudes
high altitude low PO2 in the air
hemoglobin may not
become fully saturated
tissues may not be
adequately supplied
with oxygen.
Adaptations to high altitude
increased red blood cell production
increased amount of circulating hemoglobin.
Increased ventilation rate and gas exhange
Muscles produce more myoglobin to ensure delivery of oxygen to the tissues.
http://www.asianscientist.com/wp-content/uploads/2013/07/Genomic-Analysis-Reveals-High-Altitude-Adaptations-In-A-Mongolian-Population.jpg
Adaptations to high altitudePopulations living
permanently at high altitude have
greater mean lung surface area and larger vital capacities than people living at
sea level.
Their oxygen dissociation curve shifts to the right,
encouraging release of oxygen into the tissues.
http://www.pnas.org/content/99/26/17215/F3.large.jpg
AsthmaAsthma is a chronic lung condition
that is characterized by inflammation of the air passages in the lungs.
Often the bronchioles constrict in an over-reactive fashion.
The consequence is breathing problems, coughing and shortness of breath.
It is often triggered by environmental factors such as allergies, exercise, cold, viral illness, or strong responses to environmental triggers such as pollen.
Asthma sufferers are more likely to live in industrial areas.
http://clearcorpsdetroit.org/wp-content/uploads/2012/11/child-asthma-print-version-.jpg
Asthma is often treated using drugs that act as bronchodilators or anit-inflammatories. These are usually administered by inhalation.
http://life.familyeducation.com/images/ChildAsthma_H.jpg
Answer the end of the chapter 19 questions.
Questions:
SourcesAllot, A., & Mindorff, D. (2010). IB Biology
Course Companion. New York: Oxford University Press.
Click 4 Biology. (n.d.). Option H: Gas exchange. Retrieved from http://click4biology.info/c4b/h/h6.htm
Damon, A., McGonegal, R., Tosto, P., & Ward, W. (2007). Biology Higher Level. London: Pearson Baccalaureate.