orf19.4643 ORF|Uncharacterized "Ortholog of C. dubliniensis CD36 : Cd36_41430, Candida tropicalis MYA-3404 : CTRG_00187 and Candida albicans WO-1 : CAWG_03642"orf19.339 NDE1 ORF|Verified Putative NADH dehydrogenase; may act alternatively to complex I in respiration; caspofungin repressed; rat catheter biofilm induced; Spider biofilm repressedorf19.2791 BBC1 ORF|Uncharacterized Putative SH3-domain-containing proteinorf19.6916 ORF|Uncharacterized "Ortholog(s) have unfolded protein binding activity, role in mitochondrial proton-transporting ATP synthase complex assembly and mitochondrion localization"orf19.5661 PTC7 ORF|Verified "Protein phosphatase, type 2C; has S/T phosphatase activity, Mn2+/Mg2+ dependent; predicted membrane-spanning segment and mitochondrion-targeting signal"orf19.6665 ORF|Uncharacterized "Ortholog(s) have Ran GTPase binding, nucleocytoplasmic transporter activity"orf19.946 MET14 ORF|Uncharacterized Putative adenylylsulfate kinase; predicted role in sulfur metabolism; possibly adherence-induced; protein present in exponential and stationary growth phase yeast; F-12/CO2 biofilm inducedorf19.1697 ORF|Uncharacterized "Ortholog(s) have role in cytoplasmic translation and cytoplasm, polysomal ribosome localization"orf19.1857 ORF|Uncharacterized Putative L-azetidine-2-carboxylic acid acetyltransferase; mutants are viableorf19.4288 CTA7 ORF|Verified Zn(II)2Cys6 transcription factor; activates transcription in 1-hybrid assay in S. cerevisiae; has similarity to S. cerevisiae Stb4orf19.1756 GPD1 ORF|Verified "Glycerol-3-phosphate dehydrogenase; glycerol biosynthesis; regulated by Efg1; regulated by Tsa1, Tsa1B under H2O2 stress conditions; Sflow model and Spider biofilm induced"orf19.6640 TPS1 ORF|Verified Trehalose-6-phosphate synthase; role in hyphal growth and virulence in mouse systemic infection; induced in presence of human neutrophils; macrophage/pseudohyphal-repressed after 16h; stationary phase enriched protein; Hap43-repressedorf19.1338 ORF|Uncharacterized "Protein of unknown function; possible COPI-coated vesicle, Golgi apparatus, ribosome localization; rat catheter biofilm repressed"orf19.6407 ORF|Uncharacterized "Ortholog(s) have role in ribosomal large subunit biogenesis and cytoplasm, cytosolic large ribosomal subunit, preribosome, large subunit precursor localization"orf19.6040 SNF7 ORF|Verified ESCRT III complex protein; role in proteolytic activation of Rim101 and Rim8 processing/activation; separable roles in RIM101 pathway and in transport from MVB to vacuole; involved in echinocandin and azole sensitivityorf19.2296 ORF|Uncharacterized Predicted mucin-like protein; ketoconazole-induced; fluconazole-repressed; induced in cyr1 mutant; colony morphology-related gene regulation by Ssn6; flow model biofilm induced; Spider biofilm inducedorf19.5805 DLD1 ORF|Uncharacterized Putative D-lactate dehydrogenase; white cell-specific trancript; colony morphology-related gene regulation by Ssn6; Hap43-repressed; rat catheter biofilm induced; Spider biofilm repressedorf19.2277 TPK2 ORF|Verified "cAMP-dependent protein kinase catalytic subunit; isoform of Tpk1; needed for epithelial cell damage, engulfment and oral (not systemic) virulence in mice; control of morphogenesis and stress response; rat catheter, Spider biofilm repressed"orf19.5201 ORF|Uncharacterized Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localizationorf19.1954 PUS4 ORF|Uncharacterized "Putative pseudouridine synthase; transcript regulated by Nrg1, Mig1, and Tup1"orf19.6893 ORF|Uncharacterized "Ortholog(s) have role in ER to Golgi vesicle-mediated transport, cellular response to cadmium ion, detoxification of cadmium ion"orf19.6522 ORF|Uncharacterized Putative allantoate permease; Gcn4-regulated; Spider biofilm inducedorf19.457 ORF|Uncharacterized "Ortholog(s) have ubiquitin-specific protease activity, role in protein deubiquitination, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway and cytosol localization"orf19.6809 ORF|Uncharacterized Putative phosphomutase-like protein; protein present in exponential and stationary growth phase yeast; Hap43-repressed; Spider biofilm repressedorf19.3183 ORF|Uncharacterized "Protein with a role in insertion of tail-anchored proteins into the ER membrane; required for efficient mating, in shmoo formation and nuclear migration in the pre-zygote of S. cerevisiae; Hap43-repressed"orf19.6632 ACO2 ORF|Uncharacterized Putative aconitate hydratase 2; induced in high iron; regulated by Gcn4; repressed by amino acid starvation (3-AT); protein levels decrease in stationary phase yeast; flow model and Spider biofilm repressedorf19.2970 LYS2 ORF|Verified "Heterodimeric alpha-aminoadipate reductase large subunit; lysine biosynthesis; predicted binding sites for AMP and alpha-aminoadipate; inhibited by lys or thialysine; regulated by Gcn2 and Gcn4; Spider biofilm induced, flow model repressed"orf19.5779 RNR1 ORF|Verified "Ribonucleotide reductase large subunit; induced in low iron; transposon mutation affects filamentous growth; farnesol upregulated in biofilm; regulated by cell cycle, tyrosol, cell density; regulated by Sef1, Sfu1, and Hap43"orf19.5645 MET15 ORF|Verified "O-acetylhomoserine O-acetylserine sulfhydrylase; sulfur amino acid synthesis; immunogenic; Hog1, adherence-induced; brown color of mutant in Pb(2+) medium a visual selection; chlamydospore formation induced, F-12/CO2 biofilm induced"orf19.2068 ORF|Uncharacterized "Ortholog of C. dubliniensis CD36 : Cd36_15550, C. parapsilosis CDC317 : CPAR2_213190, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119026 and Debaryomyces hansenii CBS767 : DEHA2G08514g"orf19.6553 ORF|Verified Membrane-localized protein of unknown function; possibly secreted; fluconazole-inducedorf19.203 STB3 ORF|Uncharacterized Putative SIN3-binding protein 3 homolog; caspofungin induced; macrophage/pseudohyphal-repressed; rat catheter biofilm inducedorf19.558 GUT1 ORF|Uncharacterized Putative glycerol kinase; downregulated upon adherence to polystyrene; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild typeorf19.2443 RGD1 ORF|Verified GTPase activator protein; transcript induced in low iron; alkaline upregulated; localized to the bud emergence area in G1 phase and in the bud tip during S and G2 phasesorf19.886 PAN1 ORF|Verified "Essential protein involved in endocytosis and polarized growth; ortholog of S. cerevisiae Pan1, which is a part of a complex that regulates actin cytoskeleton; Spider biofilm repressed"orf19.4437 ORF|Uncharacterized "Ortholog(s) have ATPase activity, DNA binding, nucleosome binding, rDNA binding activity"orf19.2304 ORF|Verified Protein similar to S. cerevisiae Gvp36p; transposon mutation affects filamentous growthorf19.1985 ORF|Uncharacterized Has aminoglycoside phosphotransferase and protein kinase domains; rat catheter and flow model biofilm inducedorf19.549 ORF|Uncharacterized "Ortholog(s) have structural constituent of ribosome activity and mitochondrial inner membrane, mitochondrial large ribosomal subunit localization"orf19.1789.1 LYS1 ORF|Verified Saccharopine dehydrogenase (biosynthetic); enzyme of alpha-aminoadipate lysine biosynthesis pathway; functionally complements S. cerevisiae lys1 mutation; fungal-specific (no human or murine homolog)orf19.4851 TFA1 ORF|Uncharacterized "Protein with polyglutamate motifs and abundant Ser/Thr residues; described as a subunit of TFIIE, which is a basal transcription initiation factor of RNA Polymerase II; possibly an essential gene, disruptants not obtained by UAU1 method"orf19.1764 ORF|Uncharacterized Protein of unknown function; rat catheter and Spider biofilm inducedorf19.3325 ORF|Uncharacterized Putative glycogen synthesis initiator; regulated by Efg1 and Efh1; Hog1-repressed; colony morphology-related gene regulation by Ssn6; induced by prostaglandins; flow model biofilm inducedorf19.2021 HGT8 ORF|Verified High-affinity glucose transporter of the major facilitator superfamily; 20 members in the C. albicans glucose transporter family; 12 probable membrane-spanning segments; gene has intron; expressed in rich medium; flow model biofilm inducedorf19.1442 PLB4.5 ORF|Verified Phospholipase B; Hog1-induced; regulated by Ssn6; putative GPI-anchor; repressed during cell wall regeneration; clade-associated gene expression; Hap43-induced; rat catheter and Spider biofilm repressedorf19.431 ZCF2 ORF|Verified Zn(II)2Cys6 transcription factor; regulates sulfite tolerance through expression of SSU1 and CDG1; Hap43-repressed; Spider biofilm inducedorf19.470 ORF|Uncharacterized "Ortholog(s) have RNA polymerase II activating transcription factor binding, TBP-class protein binding, chromatin binding, protein complex scaffold activity"orf19.2499 ORF|Uncharacterized Putative peptidyl-prolyl cis-trans isomeraseorf19.3213 ORF|Uncharacterized Protein of unknown function; Spider biofilm inducedorf19.4381 VTC3 ORF|Uncharacterized Putative polyphosphate synthetase; downregulated in core caspofungin response; Hog1p-induced; transcription is opaque-specific; fungal-specific (no human or murine homolog)orf19.643 ORF|Uncharacterized "Ortholog(s) have role in apoptotic process, mitotic spindle elongation, sister chromatid biorientation, spindle assembly checkpoint"orf19.7152 ORF|Uncharacterized "Protein similar to Aspergillus CYSK O-acetylserine sulfhydrylase, suggesting that C. albicans uses an O-acetyl-serine (OAS) pathway of sulfur assimilation; upregulated in biofilm; protein level decreases in stationary phase cultures"orf19.439 ORF|Uncharacterized "Ortholog(s) have recombinase activity, single-stranded DNA binding activity"orf19.2792 IST2 ORF|Uncharacterized "Ortholog(s) have lipid binding activity, role in endoplasmic reticulum membrane organization, regulation of phosphatidylinositol dephosphorylation and cellular bud membrane, cortical endoplasmic reticulum localization"orf19.6763 SLK19 ORF|Verified "Alkaline-induced protein of plasma membrane; affects cell aggregation, cell wall; similar to S. cerevisiae Slk19p (a kinetochore protein with roles in mitosis, meiosis); required for wild-type virulence in mouse; macrophage-downregulated"orf19.5426 ORF|Uncharacterized Putative patatin-like phospholipase; macrophage-regulated gene; fungal-specific (no human or murine homolog)orf19.3683 AGE3 ORF|Verified "Putative ADP-ribosylation factor GTPase activating protein, functional ortholog of S. cerevisiae GCS1; mutation affects endocytosis, hyphal growth, chemical and drug resistance, and sensitivity to cell wall inhibitors"orf19.3767 PEP1 ORF|Uncharacterized Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between late-Golgi and prevacuolar endosome-like compartments; rat catheter biofilm repressedorf19.4492 ORF|Uncharacterized "Ortholog(s) have role in nuclear division, rRNA processing and mitotic spindle pole body, nuclear periphery, nucleolus, preribosome, large subunit precursor localization"orf19.2644 QCR2 ORF|Verified Ubiquinol-cytochrome-c reductase; antigenic; induced by interaction with macrophage; repressed by nitric oxide; in detergent-resistant membrane fraction (possible lipid raft component); levels decrease in stationary phase; Hap43p-repressedorf19.3276 PWP2 ORF|Verified Putative 90S pre-ribosomal component; repressed in core stress response; repressed by prostaglandins; physically interacts with TAP-tagged Nop1; Hap43-inducedorf19.4201 NHX1 ORF|Uncharacterized "Protein similar to S. cerevisiae Nhx1p, which is an Na+/H+ exchanger required for intracellular sequestration of Na+"orf19.5505 HIS7 ORF|Uncharacterized Putative imidazole glycerol phosphate synthase; histidine biosynthesis; no human/murine homolog; transcription induced by histidine starvation; regulated by Gcn2p and Gcn4p; higher protein level in stationary phaseorf19.5137.1 HHO1 ORF|Uncharacterized Putative histone H1; farnesol regulated; Hap43-induced; contains 5' UTR intron; Spider biofilm repressedorf19.3507 MCR1 ORF|Uncharacterized "NADH-cytochrome-b5 reductase; soluble in hyphae; alkaline downregulated; farnesol, ketoconazole or flucytosine induced; protein present in exponential and stationary growth phase yeast; YNB biofilm induced; rat catheter biofilm repressed"orf19.5432 TPT1 ORF|Verified tRNA 2'-phosphotransferase; enzyme of tRNA splicing; functionally complements viability of S. cerevisiae tpt1 null mutantorf19.1623 CAP1 ORF|Verified "AP-1 bZIP transcription factor; apoptotic, oxidative stress response/resistance, multidrug resistance; nuclear in oxidative stress; complements S. cerevisiae yap1 mutant; oralpharyngeal candidasis-, human neutrophil, Spider biofilm induced"orf19.2693 GST2 ORF|Uncharacterized "Glutathione S transferase; induced by benomyl and in populations of cells exposed to fluconazole over multiple generations; regulated by Nrg1, Tup1; induced by nitric oxide; stationary phase enriched; Spider biofilm induced"orf19.448 CUE5 ORF|Uncharacterized Predicted ubiquitin-binding protein; rat catheter biofilm repressedorf19.5229 ORF|Uncharacterized "Ortholog(s) have 3'-5'-exoribonuclease activity, endoribonuclease activity, tRNA binding activity"orf19.3846 LYS4 ORF|Uncharacterized "Homoaconitase; regulated by Gcn4, Gcn2; induced in response to amino acid starvation (3-AT); induced by human whole blood or PMNs; Hap43-repressed; flow model and Spider biofilm repressed"orf19.2246 ORF|Uncharacterized "Ortholog(s) have cytosol, nucleus localization"orf19.6710 UTP9 ORF|Verified Small-subunit processome protein; Ssr1-induced; repressed by prostaglandins; physically interacts with TAP-tagged Nop1orf19.3341 ORF|Uncharacterized "Putative tRNA-Arg synthetase; essential; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; downregulated by growth in the mouse cecum"orf19.99 HAL21 ORF|Uncharacterized Putative phosphoadenosine-5'-phosphate or 3'-phosphoadenosine 5'-phosphosulfate phosphatase; possible role in sulfur recycling; ortholog of S. cerevisiae Met22; predicted Kex2 substrate; F-12/CO2 biofilm inducedorf19.4263 ORF|Uncharacterized Has domain(s) with predicted nucleotide binding activityorf19.4407 ORF|Uncharacterized Protein of unknown function; Hap43-repressed geneorf19.681 HAP43 ORF|Verified "CCAAT-binding factor-dependent transcription factor; repressor; also called CAP2; required for low iron response; similar to bZIP transcription factor AP-1; repressed by Sfu1; ciclopirox olamine induced; rat catheter, Spider biofilm induced"orf19.6927 PEP8 ORF|Verified "Protein similar to S. cerevisiae Pep8p, which is involved in retrograde transport; transposon mutation affects filamentous growth"orf19.2841 PGM2 ORF|Uncharacterized Ortholog of S. cerevisiae Pgm2; induced in planktonic culture; Tye7p-regulated; flow model biofilm induced; rat catheter biofilm repressedorf19.1119 MTR10 ORF|Uncharacterized Putative importin; member of a family of fungal-specific nuclear importins; Mig1-regulatedorf19.2525 LYS12 ORF|Verified Homoisocitrate dehydrogenase; catalyzes 4th step in the alpha-aminoadipate pathway of lysine biosynthesis; clade-associated gene expression; protein level decreases in stationary phase cultures; Spider biofilm repressedorf19.6724 FUM12 ORF|Uncharacterized "Putative fumarate hydratase; enzyme of citric acid cycle; fluconazole, Efg1 repressed; induced in high iron; protein present in exponential and stationary growth phase"orf19.7394 GDA1 ORF|Verified "Golgi membrane GDPase, required for wild-type O-mannosylation, not N-glycosylation; required for wild-type hyphal induction, cell wall, and cell surface charge; not required for HeLa cell adherence; functional homolog of S. cerevisiae Gda1p"orf19.5801 RNR21 ORF|Uncharacterized "Ribonucleoside-diphosphate reductase; regulated by tyrosol and cell density; ciclopirox olamine, fluconazole or flucytosine induced; regulated by Sef1, Sfu1, and Hap43"orf19.7522 ORF|Verified Protein with a pyridoxal phosphate-dependent transferase domain; Hap43-repressed; mutation confers hypersensitivity to amphotericin B; Spider biofilm repressedorf19.3546 PEX2 ORF|Uncharacterized "Ortholog(s) have ubiquitin-protein ligase activity, role in fatty acid metabolic process, protein import into peroxisome matrix and peroxisomal membrane localization"orf19.7344 ORF|Uncharacterized "Ortholog(s) have DNA binding, chromatin binding, histone deacetylase activity"orf19.4477 CSH1 ORF|Verified "Aldo-keto reductase; role in fibronectin adhesion, cell surface hydrophobicity; regulated by temperature, growth phase, benomyl, macrophage interaction; azole resistance associated; Spider biofilm induced; rat catheter biofilm repressed"orf19.6693 ORF|Uncharacterized "Ortholog(s) have cytosol, nucleus localization"orf19.7583 ZCF39 ORF|Verified Zn(II)2Cys6 transcription factor; mutants are viable; filament induced; required for yeast cell adherence to silicone substrate; Spider biofilm inducedorf19.4216 ORF|Uncharacterized Putative heat shock protein; decreased expression in hyphae; transcription is increased in populations of cells exposed to fluconazole over multiple generations; overexpression increases resistance to farnesol and azolesorf19.3501 ORF|Uncharacterized S. cerevisiae ortholog Pxl1 localizes to sites of polarized growth and is required for selection and/or maintenance of polarized growth sites; Hog1p-repressedorf19.6972 SMI1B ORF|Uncharacterized "Putative cell wall assembly regulatory protein; Rim101-repressed; possibly an essential gene, disruptants not obtained by UAU1 method"orf19.2092 ORF|Uncharacterized Putative peroxisomal cystathionine beta-lyase; Gcn4p-regulatedorf19.2262 ORF|Uncharacterized "Protein similar to quinone oxidoreductases; induced by benomyl treatment, nitric oxide; oxidative stress-induced via Cap1; stationary-phase enriched protein; Spider biofilm induced"orf19.338 ORF|Uncharacterized Putative glycoside hydrolase; stationary phase enriched protein; Hog1p-downregulated; shows colony morphology-related gene regulation by Ssn6p

Cluster 1

orf19.6626 ORF|Uncharacterized Predicted homeodomain-containing protein; possible transcription factor; possibly transcriptionally regulated upon hyphal formationorf19.7217 RPL4B ORF|Verified Ribosomal protein 4B; repressed upon phagocytosis by murine macrophage; Spider biofilm repressedorf19.7327 PHO88 ORF|Verified Protein with a role in phosphate transport; biofilm-regulated expression; amphotericin B repressedorf19.1402 CCT2 ORF|Uncharacterized "Chaperonin of the cytosolic TCP1 ring complex; protein present in exponential and stationary-phase yeast cells, but higher amounts in stationary phase; GlcNAc-induced protein"orf19.4660 RPS6A ORF|Verified Ribosomal protein 6A; localizes to cell surface of yeast cells but not hyphae; repressed upon phagocytosis by murine macrophage; possibly essential; Hap43-induced; Spider biofilm repressedorf19.7015 RPP0 ORF|Uncharacterized Putative ribosomal protein; antigenic in mouse; repressed upon phagocytosis by murine macrophage; induced by Tbf1; overlaps orf19.7014; Spider biofilm repressedorf19.171 DBP2 ORF|Uncharacterized Putative DEAD-box family ATP-dependent RNA helicase; flucytosine induced; repressed in core stress responseorf19.506 YDJ1 ORF|Uncharacterized Putative type I HSP40 co-chaperone; heavy metal (cadmium) stress-inducedorf19.6873 RPS8A ORF|Verified Small 40S ribosomal subunit protein; induced by ciclopirox olamine; repressed upon phagocytosis by murine macrophage; 5'-UTR intron; Hap43-induced; Spider biofilm repressedorf19.1665 MNT1 ORF|Verified "Alpha-1,2-mannosyl transferase; predicted type II Golgi membrane protein; adds 2nd mannose during cell-wall mannoprotein biosynthesis; required for wild-type virulence and adherence to epithelial cells; Hap43-induced"orf19.687.1 RPL25 ORF|Uncharacterized Putative rRNA-binding ribosomal protein component of the 60S ribosomal subunit; Hap43-induced; colony morphology-related gene regulation by Ssn6orf19.657 SAM2 ORF|Verified "S-adenosylmethionine synthetase; localizes to surface of hyphae, not yeast cells; alkaline, Hog1-induced; farnesol-downregulated; F-12/CO2 early biofilm induced; Spider biofilm repressed"orf 19.6312 RPS3 ORF|Uncharacterized "Ribosomal protein S3; Hog1, Hap43-induced; grepressed upon phagocytosis by murine macrophage; present in exponential and stationary phase cells; Spider biofilm repressed"orf19.432 ORF|Uncharacterized Predicted SCF ubiquitin ligase complex protein; Spider biofilm induced; rat catheter biofilm inducedorf19.5904 RPL19A ORF|Verified Ribosomal protein L19; repressed upon phagocytosis by murine macrophages; Hap43-induced gene; Spider biofilm repressedorf19.1470 RPS26A ORF|Alternatively spliced|Uncharacterized "Ribosomal protein; regulated by Nrg1, Tup1; repressed upon phagocytosis by murine macrophage; alternatively spliced intron in 5'-UTR; Spider biofilm repressed"orf19.3861 SIS1 ORF|Uncharacterized Putative Type II HSP40 co-chaperone; macrophage/pseudohyphal-repressed; heavy metal (cadmium) stress-induced; heterozygous null mutant displays sensitivity to virgineone; rat catheter biofilm inducedorf19.2435 MSI3 ORF|Verified Essential HSP70 family protein; required for fluconazole resistance and calcineurin-dependent transcription; interacts with Cgr1; transcript regulated by iron; rat catheter biofilm induced; farnesol repressed in biofilm; sumoylation targetorf19.3159 UTP20 ORF|Verified Putative snoRNA-binding protein; S. cerevisiae Utp20 ortholog; likely essential for growth; repressed in core stress response; mutation confers resistance to 5-fluorocytosine (5-FC) and parnafunginorf19.7347 ORF|Uncharacterized "Ortholog(s) have ubiquitin-protein ligase activity, role in ER-associated ubiquitin-dependent protein catabolic process and endoplasmic reticulum membrane localization"orf19.3192 STI1 ORF|Uncharacterized Protein that interacts with Cdc37 and Crk1 in two-hybrid; may be involved in Cdc37 chaperone activity; soluble protein in hyphae; protein in exponential and stationary phase yeast cultures; YNB biofilm induced; Spider biofilm inducedorf19.6002 RPL8B ORF|Uncharacterized Predicted ribosomal protein; regulated upon yeast-hypha switch; repressed upon phagocytosis by murine macrophage; Spider biofilm repressedorf19.5928 RPP2B ORF|Verified "Conserved acidic ribosomal protein; possibly involved in regulation of translation elongation; interacts with Rpp1A; 1 of 4 similar C. albicans proteins (Rpp1A, Rpp1B, Rpp2A, Rpp2B); macrophage/pseudohyphal-induced; Spider biofilm repressed"orf19.1635 RPL12 ORF|Uncharacterized "Ribosomal protein L12, 60S ribosomal subunit; downregulated by human whole blood or polymorphonuclear cells; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by macrophage; Tbf1p-activated; Hap43p-induced"orf19.3722 ORF|Uncharacterized Predicted protein of rapamycin resistance; Spider biofilm inducedorf19.7569 SIK1 ORF|Verified Putative U3 snoRNP protein; Hap43p-induced gene; physically interacts with TAP-tagged Nop1porf19.5710 ORF|Uncharacterized Nucleoporin component of central core of the nuclear pore complex; mRNA binds She3orf19.5964 ARF2 ORF|Verified Putative ADP-ribosylation factor; mutation confers hypersensitivity to Brefeldin A; Spider biofilm repressedorf19.1896 SSC1 ORF|Verified "Heat shock protein; at yeast-form cell surface, not hyphae; antigenic; Gcn4-regulated; induced by amino acid starvation (3-AT) or by adherence to polystyrene; macrophage-repressed; sumoylation target; possibly essential"orf19.1618 GFA1 ORF|Verified "Glucosamine-6-phosphate synthase, homotetrameric enzyme of chitin/hexosamine biosynthesis; inhibited by UDP-GlcNAc, FMDP, N-acyl peptide, kanosamine-6-P; functional homolog of S. cerevisiae Gfa1p; Cagrowth-phase regulated; catalytic Cys"orf19.5927 RPS15 ORF|Uncharacterized Putative ribosomal protein; macrophage/pseudohyphal-induced after 16 h; repressed upon phagocytosis by murine macrophage; Spider biofilm repressedorf19.7654 CPR6 ORF|Uncharacterized Putative peptidyl-prolyl cis-trans isomerase; macrophage/pseudohyphal-repressed; heavy metal (cadmium) stress-induced; heterozygous null mutant displays sensitivity to virgineone; rat catheter biofilm inducedorf19.5949 FAS2 ORF|Verified Alpha subunit of fatty-acid synthase; required for virulence in mouse systemic infection and rat oropharyngeal infection models; regulated by Efg1; fluconazole-induced; amphotericin B repressed; flow model and Spider biofilm repressedorf19.4060 ARO4 ORF|Verified 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; aromatic amino acid biosynthesis; GCN-regulated; feedback-inhibited by tyrosine if produced in S. cerevisiae Aro3p and Aro4p catalyze same reaction; protein decreases in stationary phaseorf19.5168 ORF|Uncharacterized "Ortholog(s) have role in maturation of SSU-rRNA and cytosol, nucleolus localization"orf19.4306 ORF|Uncharacterized "Ortholog(s) have methylthioribulose 1-phosphate dehydratase activity, role in L-methionine salvage from methylthioadenosine and cytoplasm localization"orf19.5466 RPS24 ORF|Uncharacterized Predicted ribosomal protein; hyphal downregulated; repressed upon phagocytosis by murine macrophage; transcriptionally activated by Tbf1; Spider biofilm repressedorf19.1662 ORF|Uncharacterized Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localizationorf19.7538 ORF|Uncharacterized DNA helicase involved in rDNA replication; Spider biofilm repressedorf19.2818 ORF|Uncharacterized "Ortholog(s) have RNA-dependent ATPase activity, second spliceosomal transesterification activity, role in generation of catalytic spliceosome for second transesterification step and U2-type catalytic step 2 spliceosome localization"orf19.1199 NOP5 ORF|Verified Ortholog of S. cerevisiae Nop58; involved in pre-rRNA process; Tn mutation affects filamentous growth; macrophage/pseudohyphal-induced; physically interacts with TAP-tagged Nop1; Spider biofilm repressedorf19.6367 SSB1 ORF|Verified "HSP70 family heat shock protein; mRNA in yeast and germ tubes; at yeast cell surface, not hyphae; antigenic in human/mouse infection; macrophage, GCN-induced; possibly essential; sumoylation target; Hap43-induced; Spider biofilm repressed"orf19.1700 RPS7A ORF|Verified "Ribosomal protein S7; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; Spider biofilm repressed"orf19.4980 HSP70 ORF|Verified "Putative hsp70 chaperone; role in entry into host cells; heat-shock, amphotericin B, cadmium, ketoconazole-induced; surface localized in yeast and hyphae; antigenic in host; farnesol-downregulated in biofilm; Spider biofilm induced"orf19.4043 ORF|Uncharacterized Protein with a predicted pleckstrin homology domain; induced by alpha pheromone in SpiderM mediumorf19.236 RPL9B ORF|Uncharacterized Ribosomal protein L9; repressed upon phagocytosis by murine macrophages; repressed by nitric oxide; protein levels decrease in stationary phase; Hap43-induced; Spider biofilm repressedorf19.2138 ILS1 ORF|Uncharacterized "Putative isoleucyl-tRNA synthetase, the target of drugs including the cyclic beta-amino acid icofungipen/PLD-118/BAY-10-8888 and mupirocin; protein present in exponential and stationary growth phase yeast cultures"orf19.2340 CDC48 ORF|Verified Putative microsomal ATPase; plasma membrane-localized; regulated by Gcn2 and Gcn4; induced by amino acid starvation (3-AT); macrophage/pseudohyphal-repressed; protein levels decrease in stationary phase yeast; Spider biofilm repressedorf19.1802 OFD1 ORF|Uncharacterized Putative prolyl hydroxylase family member; regulates Ume6p stability in response to oxygen; inhibited by hypoxia; repressed by prostaglandins; Spider biofilm inducedorf19.979 FAS1 ORF|Verified "Beta subunit of fatty-acid synthase; multifunctional enzyme; Hap43, fluconazole-induced; amphotericin B, caspofungin repressed; macrophage/pseudohyphal-induced; flow model and Spider biofilm repressed"orf19.7376 ORF|Uncharacterized "Ortholog of C. dubliniensis CD36 : Cd36_85880, C. parapsilosis CDC317 : CPAR2_806870, Candida tenuis NRRL Y-1498 : CANTEDRAFT_96983 and Debaryomyces hansenii CBS767 : DEHA2D16148g"orf19.6663 RPS25B ORF|Uncharacterized Ribosomal protein; macrophage/pseudohyphal-induced after 16 h; repressed upon phagocytosis by murine macrophage; transcript positively regulated by Tbf1; 5'-UTR intron; Hap43-induced; Spider biofilm repressedorf19.4931.1 RPL14 ORF|Verified Ribosomal protein L14; promoter bound directly by Tbf1p; Hap43p-induced geneorf19.3122.2 ORF|Uncharacterized "Ortholog(s) have role in exocytosis, filamentous growth, mRNA export from nucleus, proteasome assembly, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of cell cycle"orf19.3003.1 RPL6 ORF|Verified "Ortholog of S. cerevisiae ribosomal subunit, Rpl6B; transposon mutation affects filamentous growth; translation-related genes are downregulated upon phagocytosis by murine macrophage; Hap43-induced; Spider biofilm repressed"orf19.3504 RPL23A ORF|Alternatively spliced|Uncharacterized Ribosomal protein; downregulated upon phagocytosis by murine macrophage; Hap43-induced; sumoylation target; Spider biofilm repressedorf19.6540 PFK2 ORF|Verified "Phosphofructokinase beta subunit; fructose 2,6-bisphosphate, AMP activated; ATP inhibited; phagocytosis, hyphal repressed; fluconazole-induced; stationary-phase enriched; flow model biofilm induced; rat catheter/Spider biofilm repressed"orf19.6225 PCL7 ORF|Uncharacterized Putative cyclin-like protein; possible Pho85 cyclin; hyphal repressed; induced by Mnl1 under weak acid stressorf19.6515 HSP90 ORF|Verified "Essential chaperone, regulates several signal transduction pathways and temperature-induced morphogenesis; activated by heat shock, stress; localizes to surface of hyphae, not yeast cells; mediates echinocandin and biofilm azole resistance"orf19.6702 DED81 ORF|Uncharacterized "Putative tRNA-Asn synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein enriched in stationary phase yeast cultures"orf19.4371 TAL1 ORF|Verified Transaldolase; protein present in exponential and stationary growth phase yeast cultures; oxidative stress-induced via Cap1; induced by nitric oxide independent of Yhb1p; sumoylation target; rat catheter biofilm repressedorf19.5437 RHR2 ORF|Verified "Glycerol 3-phosphatase; roles in osmotic tolerance, glycerol accumulation in response to salt; Spider/flow model biofilm induced; regulated by macrophage, stress, yeast-hyphal switch, pheromone, Gcn4, Hog1, Nrg1, Tup1"orf19.3870 ADE13 ORF|Uncharacterized "Adenylosuccinate lyase; enzyme of adenine biosynthesis; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog; repressed by nitric oxide"orf19.6760 MDS3 ORF|Verified "TOR signaling pathway component; required for growth and hyphal formation at alkaline pH, for full virulence in a mouse model of systemic infection and for SD and Spider medium biofilm formation; role in chlamydospore formation"orf19.3462 SAR1 ORF|Verified Functional homolog of S. cerevisiae Sar1; which is required for ER-to-Golgi protein transport; binds GTP; similar to small GTPase superfamily proteins; gene has intron; Hap43-induced; rat catheter biofilm repressedorf19.3002 RPS1 ORF|Uncharacterized Putative ribosomal protein 10 of the 40S subunit; elicits host antibody response during infection; transcript induced during active growth; Spider biofilm repressedorf19.645.1 VMA13 ORF|Uncharacterized Predicted proton-transporting ATPase; predicted role in ATP hydrolysis coupled proton transport; rat catheter biofilm repressedorf19.2901 NUP60 ORF|Uncharacterized Ortholog of S. cerevisiae Nup60p; a subunit of the nuclear pore complex; mutants are viableorf19.7466 ACC1 ORF|Uncharacterized Putative acetyl-coenzyme-A carboxylases; regulated by Efg1; amphotericin B repressed; caspofungin repressed; 5'-UTR intron; gene used for strain identification by multilocus sequence typing; Hap43-induced; flow model biofilm repressedorf19.4223 GCD11 ORF|Uncharacterized "Gamma subunit of translation initiation factor eIF2; involved in identification of the start codon; likely essential for growth, based on an insertional mutagenesis strategy; Spider biofilm repressed"orf19.840 RPL21A ORF|Uncharacterized Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; Spider biofilm repressedorf19.3575 CDC19 ORF|Verified Pyruvate kinase at yeast cell surface; Gcn4/Hog1/GlcNAc regulated; Hap43/polystyrene adherence induced; repressed by phagocytosis/farnesol; hyphal growth role; stationary phase enriched; flow model biofilm induced; Spider biofilm repressed

Cluster 2

orf19.5367 RDH54 ORF|Uncharacterized Putative DNA-dependent ATPase with a predicted role in DNA recombination and repair; transcriptionally induced by interaction with macrophagesorf19.6731 0 ORF|Uncharacterized Protein of unknown function; repressed by alpha pheromone in SpiderM medium; Spider biofilm inducedorf19.5642 0 ORF|Uncharacterized Ortholog of S. cerevisiae Dif1; which regulates nuclear localization of Rnr2 and Rnr4; colony morphology-related gene regulation by Ssn6; induced in cyr1 mutant; Spider biofilm inducedorf19.2613 ECM4 ORF|Verified "Cytoplasmic glutathione S-transferase; regulated by Nrg1, Tup1; induced in core stress response, in cyr1 or ras1 mutant (yeast or hyphal cells); Tn mutation affects filamentous growth; stationary phase enriched; Spider biofilm induced"orf19.7214 0 ORF|Uncharacterized "Glucan 1,3-beta-glucosidase; regulated by Nrg1, Tup1 and possibly Tac1; induced by NO and during cell wall regeneration; stationary phase enriched; possibly essential (UAU1 method); F-12/CO2 early biofilm induced; flow biofilm repressed"orf19.7350 RCT1 ORF|Uncharacterized "Fluconazole-induced protein; Ras1, Cyr1 repressed and Efg1 induced; regulated by Nrg1, Tup1, Tbf1, Ssn6; induced in oralpharyngeal candidasis; rat catheter biofilm repressed"orf19.5921 0 ORF|Uncharacterized Ortholog(s) have glyoxysome localizationorf19.6885 SPO7 ORF|Uncharacterized Putative regulatory subunit of Nem1-Spo7 phosphatase holoenzyme that regulates nuclear growth by controling phospholipid biosynthesis; induced by alpha pheromone in SpiderM mediumorf19.2956 MGM101 ORF|Verified Putative mitochondrial genome maintenance protein; fungal-specific (no human or murine homolog); mutation confers hypersensitivity to tubercidin (7-deazaadenosine)orf19.94 0 ORF|Uncharacterized Protein of unknown function; Spider biofilm inducedorf19.7676 XYL2 ORF|Verified "D-xylulose reductase; immunogenic in mice; soluble protein in hyphae; induced by caspofungin, fluconazole, Hog1 and during cell wall regeneration; Mnl1-induced in weak acid stress; stationary phase enriched; flow model biofilm induced"orf19.2433 0 ORF|Uncharacterized "Ortholog of C. dubliniensis CD36 : Cd36_05790, C. parapsilosis CDC317 : CPAR2_103730, Pichia stipitis Pignal : PICST_28344, Candida tropicalis MYA-3404 : CTRG_04275 and Candida albicans WO-1 : CAWG_00795"orf19.3611 0 ORF|Uncharacterized Protein of unknown function; Hap43-repressed gene; repressed by nitric oxideorf19.6066 0 ORF|Uncharacterized Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; Spider biofilm inducedorf19.6753 0 ORF|Uncharacterized "Protein with a predicted RING-type zinc finger; possibly an essential gene, disruptants not obtained by UAU1 method"orf19.4317 GRE3 ORF|Uncharacterized "Putative D-xylose reductase; antigenic in murine systemic infection; soluble protein in hyphae; induced by farnesol, macrophage interaction and by Mnl1 under weak acid stress; stationary-phase enriched protein; Spider biofilm induced"orf19.4448 SOG2 ORF|Verified "Leucine-rich-repeat domain protein of RAM cell wall integrity signaling network; role in cell separation, azole sensitivity; required for hyphal growth; lacks orthologs in higher eukaryotes"orf19.5228 RIB3 ORF|Verified "3,4-Dihydroxy-2-butanone 4-phosphate synthase; homodimeric enzyme of riboflavin biosynthesis; converts ribulose 5-phosphate to L-3,4-dihydroxy-2-butanone 4-phosphate; transcription regulated on yeast-hyphal switch, macrophage interaction"orf19.1288 FOX2 ORF|Verified "3-hydroxyacyl-CoA epimerase; fatty acid beta-oxidation; induced by phagocytosis; regulated by Mig1, by white-opaque switch, by DNA methylation; transcriptional activation by oleate requires Ctf1; rat catheter and Spider biofilm induced"orf19.2511.1 MRPL33 ORF|Uncharacterized Putative mitochondrial ribosomal protein of the large subunit; Ssr1-repressed; rat catheter biofilm inducedorf19.4143 FYV5 ORF|Uncharacterized Protein with a predicted role maturation of 18S rRNA; rat catheter biofilm inducedorf19.1994 0 ORF|Uncharacterized "Ortholog(s) have phosphatidylinositol-3-phosphate binding activity, role in retrograde transport, endosome to Golgi and endosome localization"orf19.2396 IFR2 ORF|Uncharacterized "Zinc-binding dehydrogenase; induced by benomyl, ciclopirox olamine, alpha pheromone, Hap43; regulated by oxidative stress via Cap1, osmotic stress via Hog1; protein present in exponential and stationary phase; rat catheter biofilm repressed"orf19.3477 0 ORF|Uncharacterized "Putative pseudouridine synthase; predicted role in snRNA pseudouridine synthesis, tRNA pseudouridine synthesis; Spider biofilm induced"orf19.7675 0 ORF|Uncharacterized Mitochondrial ribosomal protein of the large subunit; Spider biofilm repressedorf19.5799 0 ORF|Uncharacterized Ortholog(s) have cytoplasm localizationorf19.3829 PHR1 ORF|Verified "Cell surface glycosidase; may act on cell-wall beta-1,3-glucan prior to beta-1,6-glucan linkage; role in systemic, not vaginal virulence (neutral, not low pH); high pH or filamentation induced; Bcr1-repressed in RPMI a/a biofilm"orf19.3733 IDP2 ORF|Uncharacterized "Isocitrate dehydrogenase; white-opaque switch regulated; morphology-regulation by Ssn6; protein in exponential and stationary phase yeast; Hap43-repressed; Spider biofilm repressed by Bcr1, Tec1, Ndt80, Rob1, Brg1; Spider biofilm induced"orf19.5806 ALD5 ORF|Uncharacterized "NAD-aldehyde dehydrogenase; decreased expression in fluconazole-resistant isolate, or in hyphae; biofilm induced; fluconazole-downregulated; protein abundance is affected by URA3 expression in the CAI-4 strain; stationary phase enriched"orf19.6062.3 0 ORF|Uncharacterized Mitochondrial protein; component of the mitochondrial inner membrane organizing system ; role in maintenance of crista junctions and inner membrane architecture; Spider biofilm repressedorf19.7469 ARG1 ORF|Verified "Argininosuccinate synthase; arginine synthesis; Gcn4, Rim101 regulated; induced by amino acid starvation (3-AT), benomyl treatment; stationary phase enriched protein; repressed in alkalinizing medium; rat catheter, Spider biofilm induced"orf19.4773 AOX2 ORF|Verified "Alternative oxidase; cyanide-resistant respiration; induced by antimycin A, oxidants; growth; Hap43, chlamydospore formation repressed; rat catheter, Spider biofilm induced; regulated in Spider biofilms by Bcr1, Tec1, Ndt80, Brg1"orf19.2952 EXG2 ORF|Verified "GPI-anchored cell wall protein, similar to S. cerevisiae exo-1,3-beta-glucosidase Exg2p; predicted Kex2p substrate; induced during cell wall regeneration; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-repressed"orf19.1283 MEC1 ORF|Verified Cell cycle checkpoint protein with a role in genome integrity; RNA abundance regulated by tyrosol and cell densityorf19.2306 0 ORF|Uncharacterized "Ortholog(s) have acireductone dioxygenase (Ni2+-requiring) activity, role in L-methionine salvage from methylthioadenosine and cytosol, nucleus localization"orf19.1658 0 ORF|Uncharacterized "Ortholog(s) have cell cortex, cellular bud neck, cellular bud tip, mating projection tip localization"orf19.3475 0 ORF|Uncharacterized "Described as a Gag-related protein; hyphal induced; downregulation correlates with clinical development of fluconazole resistance; repressed by nitric oxide, 17-beta-estradiol, ethynyl estradiol"orf19.3139 0 ORF|Uncharacterized Putative NADP-dependent oxidoreductase; Hap43-repressed; induced by benomyl treatment; oxidative stress-induced via Cap1; rat catheter biofilm repressedorf19.7514 PCK1 ORF|Uncharacterized "Phosphoenolpyruvate carboxykinase; glucose, C-source, yeast-hypha, Hap43 regulated; fluconazole, phagocytosis, H2O2, oral candidasis, Spider/rat catheter/flow model biofilm induced; repressed in biofilm by Bcr1, Tec1, Ndt80, Rob1, Brg1"orf19.2531 CSP37 ORF|Verified "Hyphal cell wall protein; role in progression of mouse systemic infection; predicted P-loop, divalent cation binding, N-glycosylation sites; expressed in yeast and hyphae; hyphal downregulated; stationary-phase enriched; GlcNAc-induced"orf19.3152 AMO2 ORF|Verified Protein similar to A. niger predicted peroxisomal copper amino oxidase; mutation confers hypersensitivity to toxic ergosterol analog; F-12/CO2 early biofilm inducedorf19.4833 MLS1 ORF|Verified "Malate synthase; glyoxylate cycle enzyme; no mammalian homolog; regulated upon white-opaque switch; phagocytosis, strong oxidative stress induced; stationary phase enriched; flow model biofilm repressed; rat catheter, Spider biofilm induced"orf19.113 CIP1 ORF|Verified "Possible oxidoreductase; transcript induced by cadmium but not other heavy metals, heat shock, yeast-hypha switch, oxidative stress (via Cap1), or macrophage interaction; stationary phase enriched protein; Spider biofilm induced"orf19.539 LAP3 ORF|Uncharacterized Putative aminopeptidase; positively regulated by Sfu1; clade-associated gene expression; virulence-group-correlated expression; induced by alpha pheromone in SpiderM medium; Hap43-induced; Spider and flow model biofilm inducedorf19.1972 0 ORF|Uncharacterized "Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity, role in histone lysine methylation and cytoplasm, nuclear chromatin localization"orf19.6853 0 ORF|Uncharacterized Protein of unknown function; Spider biofilm repressedorf19.4066 0 ORF|Uncharacterized Putative glycerol-3-phosphate acyltransferase; Hog1-repressedorf19.1743 ACS1 ORF|Uncharacterized "Acetyl-CoA synthetase; induced by human neutrophils; fluconazole-repressed; regulated by Nrg1/Mig1; colony morphology-related gene regulation by Ssn6; only in stationary phase cultures; rat catheter biofilm repressed, Spider biofilm induced"orf19.1259 0 ORF|Uncharacterized "Ortholog(s) have DNA binding, ubiquitin-protein ligase activity and role in histone catabolic process, histone ubiquitination, regulation of transcription from RNA polymerase II promoter in response to oxidative stress"orf19.5620 0 ORF|Uncharacterized "Stationary phase enriched protein; Gcn4-regulated; induced by amino acid starvation (3-AT), benomyl or in azole-resistant strain that overexpresses MDR1; flow model biofilm induced; rat catheter biofilm repressed; overlaps orf19.5621"orf19.6844 ICL1 ORF|Verified "Isocitrate lyase; glyoxylate cycle enzyme; required for virulence in mice; induced upon phagocytosis by macrophage; farnesol regulated; Pex5-dependent peroxisomal localization; stationary phase enriched; rat catheter, Spider biofilm induced"orf19.3419 MAE1 ORF|Uncharacterized "Malic enzyme, mitochondrial; transcription regulated by Mig1, Tup1; colony morphology-related gene regulation by Ssn6; Hap43-repressed; Spider biofilm repressed"orf19.4388 0 ORF|Uncharacterized "Protein with a histone fold domain; similar to TAFII47 proteins from S. cerevisiae, Danio rerio, Drosophila melanogaster, human, and mouse"orf19.837.1 INO4 ORF|Verified "Transcription factor; activator that forms a heterodimer with Ino2; likely regulates genes involved in phosphatidylcholine and phosphatidylinositol biosynthesis, fatty acid beta-oxidation, and peroxisome biogenesis; gene has intron"orf19.2467 PRN1 ORF|Uncharacterized Protein with similarity to pirins; induced by benomyl and in response to alpha pheromone in SpiderM medium; transcript induced by Mnl1 in weak acid stress; rat catheter and Spider biofilm inducedorf19.6533 MSK1 ORF|Uncharacterized Putative mitochondrial lysine-tRNA synthetase; flucytosine repressedorf19.185 0 ORF|Uncharacterized "Ortholog(s) have structural constituent of ribosome activity, role in mitochondrial translational initiation and mitochondrial small ribosomal subunit localization"orf19.997 SNL1 ORF|Verified Ribosome-associated protein predicted to function in protein synthesis; 1 predicted transmembrane domain; rat catheter biofilm repressed

Cluster 3

orf19.5519 GCV1 ORF|Uncharacterized Putative T subunit of glycine decarboxylase; transcript negatively regulated by Sfu1; Spider biofilm repressedorf19.3947 ORF|Uncharacterized Ortholog(s) have rDNA binding activityorf19.1889 ORF|Uncharacterized Putative phosphoglycerate mutase family protein; stationary phase enriched protein; early-stage flow model biofilm induced; Spider biofilm repressedorf19.6082 ORF|Verified "Ortholog(s) have unfolded protein binding activity, role in protein folding, protein localization to cell surface and integral to endoplasmic reticulum membrane, mitochondrial outer membrane localization"orf19.5982 RPL18 ORF|Uncharacterized "Predicted ribosomal protein; Plc1p-regulated, Tbf1-activated; repressed upon phagocytosis by murine macrophage; Hap43p-induced; Spider biofilm repressed"orf19.6178 FBP1 ORF|Verified "Fructose-1,6-bisphosphatase; key gluconeogenesis enzyme; regulated by Efg1, Ssn6; induced by phagocytosis; effects switch from glycolysis to gluconeogenesis in macrophage; rat flow model biofilm induced; overlaps orf19.6179"orf19.3651 PGK1 ORF|Verified "Phosphoglycerate kinase; localizes to cell wall and cytoplasm; antigenic in murine/human infection; flow model biofilm, Hog1-, Hap43-, GCN-induced; repressed upon phagocytosis; repressed in Spider biofilms by Bcr1, Ndt80, Rob1, Brg1"orf19.2208 ORF|Uncharacterized Ortholog(s) have role in response to salt stress and cytoplasm localizationorf19.7510 KIN2 ORF|Uncharacterized "Protein with similarity to S. cerevisiae Kin2p, transcription is positively regulated by Tbf1"orf19.4191.1 ORF|Uncharacterized "Ortholog(s) have ubiquitin-ubiquitin ligase activity, role in ER-associated ubiquitin-dependent protein catabolic process, protein polyubiquitination and cytosol, nuclear envelope, proteasome complex localization"orf19.3052 YPT1 ORF|Verified "Functional homolog of S. cerevisiae Ypt1p, which is an essential small Ras-type GTPase involved in protein secretion at ER-to-Golgi; dominant-negative mutation causes SAP secretion defect and accumulation of intracellular secretory vesicles"orf19.2416.1 MLC1 ORF|Verified "Microtubule-dependent localized protein; at Spitzenkorper and cytokinetic ring in hyphae; cell-cycle dependent localization to tip polarisome, bud neck in yeast and pseudohyphae; sumoylation target; rat catheter, Spider biofilm repressed"orf19.5076 PFY1 ORF|Verified "Profilin; functional homolog of S. cerevisiae Pfy1; hyphae, macrophage/pseudohyphal-induced; regulated by Nrg1, Tup1; gene lacks intron (unlike S. cerevisiae PFY1); complements growth of S. cerevisiae srv2 mutant; nonessential"orf19.3049 ORF|Uncharacterized "Ortholog(s) have protein kinase activity, role in activation of bipolar cell growth, ascospore wall assembly, protein phosphorylation and cell division site, cytosol, nucleus, prospore membrane localization"orf19.4609 ORF|Uncharacterized Putative dienelactone hydrolase; protein abundance is affected by URA3 expression in the CAI-4 strain background; protein present in exponential and stationary growth phase yeast cultures; rat catheter biofilm repressedorf19.3268 TMA19 ORF|Uncharacterized "Cell wall protein, ortholog of S. cerevisiae Tma19p (Ykl065cp)"orf19.7511 ORF|Uncharacterized "Ortholog(s) have structural constituent of nuclear pore activity and role in cell division, nuclear pore organization, regulation of mitotic cell cycle"orf19.385 GCV2 ORF|Uncharacterized Glycine decarboxylase P subunit; protein of glycine catabolism; repressed by Efg1; Hog1-induced; induced by Rim101 at acid pH; transcript induced in elevated CO2; stationary phase enriched proteinorf19.2994.1 RPS16A ORF|Uncharacterized Putative 40S ribosomal subunit; macrophage/pseudohyphal-induced after 16 h; Spider biofilm repressedorf19.2360 URA2 ORF|Uncharacterized Putative bifunctional carbamoylphosphate synthetase-aspartate transcarbamylase; flucytosine induced; macrophage/pseudohyphal-induced; 5'-UTR intron; flow model biofilm repressedorf19.2877 PDC11 ORF|Verified "Pyruvate decarboxylase; antigenic; on hyphal not yeast cell surface; Hap43, Gcn4, Efg1, Efh1, Hsf1 regulated; fluconazole, farnesol induced; amino acid starvation repressed; flow model biofilm induced; Spider biofilm repressed"orf19.3298 CCH1 ORF|Verified "Voltage-gated Ca2+ channel of the high affinity calcium uptake system; roles in thigmotropism, establishment of galvanotropism; transcript regulated by Nrg1 and Mig1; flow model biofilm repressed"orf19.4040 ILV3 ORF|Uncharacterized "Dihydroxyacid dehydratase; repressed by nitric oxide; macrophage-induced protein; protein in exponential and stationary growth phase; Sef1, Sfu1p, Hap43-regulated; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed"orf19.7160 ORF|Uncharacterized Ortholog(s) have unfolded protein binding activityorf19.6589 SSF1 ORF|Uncharacterized Protein involved in ribosome biogenesis; ortholog of S. cerevisiae Ssf1; Hap43-induced; rat catheter and Spider biofilm inducedorf19.7238 NPL3 ORF|Verified Putative RNA-binding protein; required for normal flow model biofilm growth; nuclear export is facilitated by Hmt1p; transcript upregulated in RHE model of oralcandidiasis; Spider biofilm repressedorf19.2023 HGT7 ORF|Verified "Putative MFS glucose transporter; glucose, fluconazole, Snf3 induced, expressed at high glucose; 20 member C. albicans glucose transporter family; 12 TM regions predicted; flow model biofilm induced; Spider biofilm repressed"orf19.4565 BGL2 ORF|Verified "Cell wall 1,3-beta-glucosyltransferase; mutant has cell-wall and growth defects, but wild-type 1,3- or 1,6-beta-glucan content; antigenic; virulence role in mouse systemic infection; rat catheter biofilm induced"orf19.7438 UBA1 ORF|Uncharacterized Ubiquitin-activating enzyme; protein level decreases in stationary phase culturesorf19.395 ENO1 ORF|Verified "Enolase; glycolysis and gluconeogenesis; major cell-surface antigen; binds host plasmin/plasminogen; immunoprotective; Hap43, phagocytosis induced; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed; may be essential"orf19.5653 ATP2 ORF|Verified "F1 beta subunit of F1F0 ATPase complex; antigenic in human, mice; induced by ciclopirox olamine; caspofungin repressed; macrophage/pseudohyphal-induced; detected during exponential and stationary growth phases; Spider biofilm repressed"orf19.6317 ADE6 ORF|Uncharacterized "5-Phosphoribosylformyl glycinamidine synthetase; adenine biosynthesis; not induced in GCN response, in contrast to S. cerevisiae Ade6; protein in stationary phase yeast-form cultures; flow model and rat catheter biofilm repressed"orf19.3014 BMH1 ORF|Alternatively spliced|Verified "Sole 14-3-3 protein in C. albicans; role in hyphal growth; possibly regulated by host interaction; localizes to yeast-form cell surface, not hyphae; alternatively spliced 5' UTR intron; Spider biofilm repressed"orf19.5285 PST3 ORF|Uncharacterized Putative flavodoxin; YNB biofilm induced; stationary phase enriched protein; rat catheter and Spider biofilm repressedorf19.269 SES1 ORF|Verified "Seryl-tRNA synthetase; charges the tRNA that recognizes the CUG codon, which typically specifies Leu, but specifies Ser in C. albicans; complements S. cerevisiae ses1 mutant viability; soluble protein in hyphae; macrophage-regulated"orf19.713 ORF|Uncharacterized "Ortholog(s) have role in apoptotic process and cytoplasm, nucleus localization"orf19.2489 ORF|Uncharacterized Putative karyopherin beta; repressed by nitric oxideorf19.6561 LAT1 ORF|Uncharacterized Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex; sumoylation target; Spider biofilm repressedorf19.7308 TUB1 ORF|Verified "Alpha-tubulin; gene has intron; complements cold-sensitivity of S. cerevisiae tub1 mutant; C. albicans has single alpha-tubulin gene, whereas S. cerevisiae has two (TUB1, TUB3); farnesol-upregulated in biofilm; sumoylation target"orf19.251 GLX3 ORF|Verified "Glutathione-independent glyoxalase; binds human immunoglobulin E; alkaline, fluconazole, Hog1 repressed; hypoxia, oxidative stress via Cap1, Hap43 induced; stationary-phase enriched; rat catheter, Spider biofilm induced"orf19.2432 HAC1 ORF|Verified bZIP transcription factor; role in unfolded protein response and control of morphology; transcript undergoes atypical splicing at C terminus under ER stress; induced during mating and by caspofungin; mRNA binds She3; Spider biofilm inducedorf19.4499 RIM2 ORF|Verified Putative mitochondrial carrier protein; induced by alpha pheromone in SpiderM medium; Spider biofilm inducedorf19.2762 AHP1 ORF|Verified "Alkyl hydroperoxide reductase; immunogenic; fluconazole-induced; amphotericin B, caspofungin, alkaline repressed; core stress response induced; Ssk1/Nrg1/Tup1/Ssn6/Hog1 regulated; flow model biofilm induced; rat catheter biofilm repressed"orf19.7571 UBC4 ORF|Uncharacterized Ortholog(s) have ubiquitin binding activityorf19.434 PRD1 ORF|Uncharacterized "Putative proteinase; transcript regulated by Nrg1, Mig1, and Tup1; Hogp-induced; stationary phase enriched protein; Hap43-repressed; rat catheter biofilm repressed"orf19.6789 ORF|Uncharacterized S. cerevisiae ortholog Nud1 is a spindle pole body outer plaque component; it acts through the mitotic exit network to specify asymmetric spindle pole body inheritance; Hap43-induced geneorf19.5773 ORF|Uncharacterized Putative dipeptidyl-peptidase III; protein detected by mass spec in exponential and stationary phase cultures; Hog1p-induced; clade-associated gene expressionorf19.5061 "ADE5,7" ORF|Verified "Phosphoribosylamine-glycine ligase and phosphoribosylformylglycinamidine cyclo-ligase; interacts with Vps34p; required for hyphal growth and virulence; flucytosine induced; not induced in GCN response, in contrast to S. cerevisiae ortholog"orf19.4004 CCT3 ORF|Verified Putative cytosolic chaperonin Cct ring complex subunit; mutation confers hypersensitivity to cytochalasin Dorf19.4309 GRP2 ORF|Verified "Methylglyoxal reductase; regulation associated with azole resistance; induced in core stress response or by oxidative stress via Cap1, fluphenazine, benomyl, by Hap43 or with long term fluconazole treatment; Spider biofilm induced"orf19.5793 PR26 ORF|Uncharacterized "Protein with similarity to proteasomal 26S regulatory subunit of S. cerevisiae, H. sapiens, Methanobacterium thermoautotrophicum (Archaebacterium)"orf19.6882.1 ORF|Uncharacterized Ribosomal 60S subunit protein; Spider biofilm repressedorf19.3888 PGI1 ORF|Uncharacterized "Glucose-6-phosphate isomerase; enzyme of glycolysis; antigenic; Efg1-regulated; induced upon adherence to polystyrene; repressed by phagocytosis, human neutrophils; flow model biofilm induced; rat catheter and Spider biofilm repressed"orf19.410.3 RIB4 ORF|Verified "Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase); catalyzes the penultimate step in the synthesis of riboflavin; Hap43-induced; rat catheter and Spider biofilm repressed"orf19.4826 IDH1 ORF|Uncharacterized Putative mitochondrial NAD-isocitrate dehydrogenase subunit 1; soluble protein in hyphae; protein level decrease in stationary phase culturesorf19.2166 VMA5 ORF|Verified Putative vacuolar H(+)-ATPase; plasma membrane localized; rat catheter biofilm repressedorf19.3599 TIF4631 ORF|Uncharacterized Putative translation initiation factor eIF4G; overexpression causes hyperfilamentation; hyphal- and macrophage-induced; genes encoding some translation factors are downregulated upon phagocytosis by murine macrophageorf19.5917.3 RNA binding protein required for export of poly(A)+ mRNA from the nucleus; Spider biofilm repressed

Cluster 4

orf19.728 TSC11 ORF|Verified Protein similar to S. cerevisiae Tsc11p which is involved in sphingolipid biosynthesis; transposon mutation affects filamentous growthorf19.3526 ITR1 ORF|Verified "MFS inositol transporter; uptake of exogenous inositol; 12 transmembrane motifs; expressed in rich medium; fluconazole, caspofungin repressed; possibly essential (UAU1 method); flow model, rat catheter and Spider biofilm induced"orf19.5553 ORF|Uncharacterized "Ortholog(s) have methionine-R-sulfoxide reductase activity, role in cellular response to oxidative stress and cytoplasm, nucleus localization"orf19.2324 UBA4 ORF|Uncharacterized Putative ubiquitin activating protein; Hap43-repressed; induced by prostaglandins; clade-associated gene expressionorf19.5445 GLO3 ORF|Uncharacterized "Putative ARF GTPase activator; role in COPI coating of Golgi vesicle, ER to Golgi vesicle-mediated transport, retrograde Golgi to ER vesicle-mediated transport; Spider biofilm repressed"orf19.7269 ORF|Uncharacterized "Putative polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and aralkylamines (e.g. tryptamine, phenylethylamine); Spider biofilm repressed"orf19.4829 DOA1 ORF|Verified WD repeat protein; required for ubiquitin-mediated protein degradation; role in control of cellular ubiquitin levels; may promote efficient NHEJ in postdiauxic/stationary phase; Spider biofilm repressedorf19.6063 UBP6 ORF|Uncharacterized Putative ubiquitin-specific protease of the 26S proteasome; oxidative stress-induced via Cap1porf19.6955 HBR3 ORF|Uncharacterized Essential protein; regulated by hemoglobin; S. cerevisiae ortholog is essential; Hap43p-induced geneorf19.1673 PPT1 ORF|Uncharacterized Putative serine/threonine phosphatase; induced in high ironorf19.3349 ORF|Verified Putative RNA polymerase II subunit B150; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness testorf19.4171 ORF|Uncharacterized Has domain(s) with predicted ATP binding activityorf19.6991 PRE3 ORF|Uncharacterized Putative beta-1 proteasome subunit; macrophage-induced protein; regulated by Gcn2p and Gcn4p; GlcNAc-induced proteinorf19.7182 ORF|Uncharacterized "Ortholog(s) have RNA binding activity, role in tRNA modification and cytoplasm, nucleus localization"orf19.1462 SMP2 ORF|Uncharacterized Putative Mg2+-dependent phosphatidate phosphatase; transcript regulated by Nrg1orf19.933 ORF|Uncharacterized "Ortholog(s) have protein homodimerization activity, ubiquitin-protein ligase activity and role in UV-damage excision repair, free ubiquitin chain polymerization, postreplication repair, protein K63-linked ubiquitination"orf19.6749 KRS1 ORF|Uncharacterized Putative tRNA-Lys synthetase; repressed upon phagocytosis by murine macrophages; stationary phase enriched protein; Spider biofilm repressedorf19.1221 ALG2 ORF|Uncharacterized "Putative mannosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants"orf19.5647 SUB2 ORF|Uncharacterized Putative TREX complex component with a predicted role in nuclear mRNA export; transcription is regulated by Mig1; Hap43-induced gene; Spider biofilm repressedorf19.315 ORF|Uncharacterized "Ortholog of C. dubliniensis CD36 : Cd36_83120, C. parapsilosis CDC317 : CPAR2_103220, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112860 and Debaryomyces hansenii CBS767 : DEHA2G08360g"orf19.441 RPT1 ORF|Uncharacterized Putative 26S proteasome regulatory subunit 7; Hap43p-repressed gene; regulated by Gcn2p and Gcn4p; overlaps orf19.442orf19.1453 SPT5 ORF|Verified Protein similar to S. cerevisiae Spt5p transcription elongation factor; transposon mutation affects filamentous growthorf19.2549 SHP1 ORF|Verified "Regulator of the type 1 protein phosphatase Glc7p activity, involved in control of morphogenesis, progression through the cell cycle and response to DNA damage"orf19.1680 TFP1 ORF|Uncharacterized Subunit of vacuolar H+-ATPase; stationary phase enriched protein; sumoylation target; Spider biofilm repressedorf19.2720 ORF|Uncharacterized Cytosolic chaperonin Cct ring complex subunit; role in the assembly of actin and tubulins; Spider biofilm repressedorf19.5858 EGD2 ORF|Verified Nascent polypeptide associated complex protein alpha subunit; soluble protein in hyphae; macrophage/pseudohyphal-induced; protein level decrease in stationary phase cultures; GlcNAc-induced protein; Spider biofilm repressedorf19.4779 ORF|Uncharacterized Putative transporter; slightly similar to the Sit1p siderophore transporter; Gcn4p-regulated; fungal-specific; induced by Mnl1p under weak acid stressorf19.163 PAN6 ORF|Uncharacterized "Ortholog(s) have pantoate-beta-alanine ligase activity, role in pantothenate biosynthetic process and cytosol, nucleus localization"orf19.7216 YPT52 ORF|Verified "Rab-family GTPase involved in vacuolar trafficking, colocolizes with Vps1p and Ypt53p in late endosome"orf19.1649 RNA1 ORF|Uncharacterized Putative GTPase-activating protein; protein level decreases in stationary phase cultures; Spider biofilm repressedorf19.819 ORF|Uncharacterized Ortholog(s) have role in lipoate biosynthetic process and mitochondrion localizationorf19.2598 VMA4 ORF|Uncharacterized H+ transporting ATPase E chain; transcript regulated by Mig1; caspofungin repressed; protein level decreases in stationary phase cultures; rat catheter biofilm repressedorf19.5788 EFT2 ORF|Verified Elongation Factor 2 (eEF2); GTPase; essential; highly expressed; target of sordarin antifungals; antigenic in human/mouse; lacks site for regulatory phosphorylation by eEF2 kinase; GCN-regulated; higher protein amount in stationary phaseorf19.7378 ORF|Uncharacterized "Ortholog(s) have phosphopantothenoylcysteine decarboxylase activity, protein phosphatase inhibitor activity and role in regulation of mitotic cell cycle, response to salt stress"orf19.3579 ATP4 ORF|Verified Putative F0-ATP synthase subunit 4; macrophage/pseudohyphal-induced; present in exponential and stationary growth phasesorf19.3527 CYT1 ORF|Verified "Cytochrome c1; induced in high iron; alkaline repressed; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43-repressed; Spider biofilm repressed"orf19.996 ORF|Uncharacterized "Protein with a predicted leucine-rich repeat domain; possibly an essential gene, disruptants not obtained by UAU1 method"orf19.3294 MBF1 ORF|Uncharacterized Putative transcriptional coactivator; caspofungin repressedorf19.550 PDX3 ORF|Uncharacterized "Pyridoxamine-phosphate oxidase; transcript regulated by yeast-hypha switch and by Nrg1, Mig1, Tup1; Hap43, caspofungin repressed; present in exponential and stationary phase yeast cultures"orf19.4928 SEC2 ORF|Verified Guanyl-nucleotide exchange factor for the small G-protein Sec4; delivery of post-Golgi secretory vesicles to sites of polarized growth; phosphorylation by Cdc28 needed for normal hyphal growth; Hap43-repressed; flow model biofilm inducedorf19.512 ORF|Uncharacterized Ortholog of S. cerevisiae Kre33; essential; S. cerevisiae ortholog is essential and is required for biogenesis of the small ribosomal subunitorf19.828 ORF|Uncharacterized "Putative ribosomal protein, large subunit, mitochondrial precursor; repressed by prostaglandins; Spider biofilm repressed"orf19.3063 HFL1 ORF|Uncharacterized HAP5-like; ortholog of S. cerevisiae Dpb3; third-largest subunit of DNA polymerase II (DNA polymerase epsilon); phosphorylated protein; mutants have a growth defectorf19.5749 SBA1 ORF|Uncharacterized "Similar to co-chaperones; induced in high iron; farnesol-, heavy metal (cadmium) stress-induced; protein level decreases in stationary phase cultures; Hap43-repressed"orf19.1682 ORF|Verified Membrane protein; Hap43p-repressed gene; repressed by nitric oxideorf19.6155 ORF|Uncharacterized "Ortholog(s) have DNA ligase (ATP) activity and role in DNA ligation, DNA recombination, DNA replication, Okazaki fragment processing, base-excision repair, mitotic cell cycle, nucleotide-excision repair, telomere maintenance"orf19.2407 DPS1-1 ORF|Uncharacterized "Putative tRNA-Asp synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein enriched in stationary phase yeast cultures"orf19.3465 RPL10A ORF|Uncharacterized Predicted ribosomal protein; downregulated upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed

Cluster 5

orf19.3009 ORF|Uncharacterized "Ortholog of S. cerevisiae : YDR179W-A, C. glabrata CBS138 : CAGL0F05819g, C. dubliniensis CD36 : Cd36_02970, C. parapsilosis CDC317 : CPAR2_108540 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_132957"orf19.7058 ORF|Uncharacterized "Ortholog(s) have role in cellular response to cadmium ion, detoxification of cadmium ion and cytoplasm, nucleus localization"orf19.6306 ORF|Verified "Trimethylaminobutyraldehyde dehydrogenase, the third enzyme of the carnitine biosynthesis pathway"orf19.1707 ORF|Uncharacterized Ortholog of Candida albicans WO-1 : CAWG_02476orf19.4340.1 ORF|Uncharacterized "Ortholog(s) have role in mRNA splicing, via spliceosome and U1 snRNP, U2 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, cytosol localization"orf19.6272 ORF|Uncharacterized Putative ubiquitin C-terminal hydrolase; regulated by Gcn2p and Gcn4porf19.3150 GRE2 ORF|Verified Putative reductase; Nrg1 and Tup1-regulated; benomyl- and hyphal-induced; macrophage/pseudohyphal-repressed; repressed by low iron; possibly involved in osmotic stress response; stationary phase enriched protein; Spider biofilm inducedorf19.813 ORF|Uncharacterized Protein of unknown function; mutants are viable; Hap43-induced gene; oxidative stress-induced via Cap1; rat catheter and Spider biofilm inducedorf19.2013 KAR2 ORF|Verified Similar to Hsp70 family chaperones; role in translocation of proteins into the ER; induced in high iron; protein present in exponential and stationary growth phase yeast cultures; flow model and Spider biofilm repressedorf19.1409.1 ORF|Uncharacterized Ribosomal 60S subunit protein L22B; Spider biofilm repressedorf19.1839 RPA190 ORF|Uncharacterized Putative RNA polymerase I subunit A190; Hap43p-induced gene; flucytosine inducedorf19.1065 SSA2 ORF|Verified "HSP70 family chaperone; cell wall fractions; antigenic; beta-defensin peptides impport; ATPase domain binds histatin 5; at hyphal surface, not yeast; farnesol-repressed in biofilm; flow model, Spider biofilm repressed; caspofungin repressed"orf19.2406 ORF|Uncharacterized "Ortholog(s) have role in microautophagy, positive regulation of TOR signaling cascade, positive regulation of transcription from RNA polymerase II promoter"orf19.4545 SWI4 ORF|Verified "Putative component of the SBF transcription complex involved in G1/S cell-cycle progression; periodic mRNA expression, peak at cell-cycle G1/S phase; predicted, conserved MBF binding sites upstream of G1/S-regulated genes"orf19.4044 MUM2 ORF|Uncharacterized "Protein similar to S. cerevisiae Mum2, a protein essential for meiotic DNA replication and sporulation; induced by alpha pheromone in SpiderM medium; transcript regulated by Tup1"orf19.6982 ORF|Uncharacterized Ortholog(s) have ribosome binding activity and mitochondrion localizationorf19.2330 ORF|Verified Putative U3 snoRNA-associated protein; Hap43-induced; transposon mutation affects filamentous growth; repressed by prostaglandinsorf19.1619 ORF|Uncharacterized "Putative kinase subunit of RNA polymerase II carboxy-terminal domain kinase I; possibly an essential gene, disruptants not obtained by UAU1 method"orf19.7082 ORF|Uncharacterized S-adenosylmethionine transporter of the mitochondrial inner membrane; mitochondrial carrier family; predicted role in biotin biosynthesis and respiratory growth; Spider biofilm repressedorf19.1005 ORF|Uncharacterized Protein with predicted RNI-like domains; rat catheter biofilm inducedorf19.980 ORF|Uncharacterized "Ortholog(s) have inositol heptakisphosphate kinase activity, inositol hexakisphosphate 1-kinase activity, inositol hexakisphosphate 3-kinase activity, inositol hexakisphosphate 4-kinase activity, inositol hexakisphosphate 6-kinase activity"orf19.4310 ORF|Dubious Dubious open reading frameorf19.7611 TRX1 ORF|Verified "Thioredoxin; involved in response to reactive oxygen species; biofilm, benomyl, flucytosine, peroxide, Hap43 induced; amphotericin B, caspofungin repressed; induced by human neutrophils; macrophage-repressed gene"orf19.882 HSP78 ORF|Uncharacterized "Heat-shock protein; regulated by macrophage response, Nrg1, Mig1, Gcn2, Gcn4, Mnl1p; heavy metal (cadmium) stress-induced; stationary phase enriched protein; rat catheter and Spider biofilm induced"orf19.5885 ORF|Uncharacterized Putative U3 snoRNP protein; flucytosine inducedorf19.1772 ORF|Uncharacterized Ortholog(s) have mitochondrion localizationorf19.4502 ORF|Uncharacterized "Ortholog(s) have ATPase activity, DNA binding, TBP-class protein binding activity"orf19.2754 TIM13 ORF|Uncharacterized Predicted mitochondrial intermembrane space protein with a role in protein import into mitochondriaorf19.6324 VID27 ORF|Verified Protein similar to S. cerevisiae Vid27p; transposon mutation affects filamentous growth; mutation confers hypersensitivity to toxic ergosterol analog; fungal-specific (no human or murine homolog)orf19.1509 ROD1 ORF|Uncharacterized Protein similar to S. cerevisiae Rod1;a membrane protein with a role in drug tolerance; repressed by Rgt1; mutant is viableorf19.5305 RHD3 ORF|Verified GPI-anchored yeast-associated cell wall protein; induced in high iron; clade-associated gene expression; not essential for cell wall integrity; fluconazole-repressed; flow model and Spider biofilm repressedorf19.4525 ORF|Uncharacterized "Ortholog(s) have endoplasmic reticulum, nuclear pore localization"orf19.4193.1 RPS13 ORF|Uncharacterized Putative ribosomal protein of the small subunitorf19.5996.1 RPS19A ORF|Uncharacterized Putative ribosomal protein S19; protein level decreases in stationary phase cultures; Spider biofilm repressedorf19.5751 ORM1 ORF|Verified Putative endoplasmic reticulum membrane protein; Hap43p-repressed gene; mutation confers hypersensitivity to aureobasidin Aorf19.5970 ORF|Uncharacterized Putative DNA repair helicase; transcriptionally induced by interaction with macrophage; fungal-specific (no human or murine homolog)orf19.30 SPF1 ORF|Verified "P-type calcium-transporting ATPase, involved in control of calcium homeostasis, response to ER stress, hyphal growth, biofilm formation and virulence"orf19.2179.2 RPS10 ORF|Verified Ribosomal protein S10; downregulated in the presence of human whole blood or PMNs; Spider biofilm repressedCaalfMp08 COX1 ORF|Uncharacterized "Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial (mt) inner membrane electron transport chain; one of three mt-encoded subunits; alternatively spliced transcripts encode 4 putative splicing endonucleases"orf19.6059 TTR1 ORF|Verified Putative glutaredoxin; described as a glutathione reductase; induced by human neutrophils and benomyl treatment; alkaline repressed; regulated by Gcn2 and Gcn4; required for virulence in mouse model; Spider biofilm inducedorf19.5166 DBF4 ORF|Uncharacterized Putative Cdc7p-Dbf4p kinase complex regulatory subunit; Hap43p-induced gene; macrophage/pseudohyphal-repressed; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog is not cell-cycle regulatedorf19.2755 ORF|Uncharacterized "Ortholog(s) have role in proteasomal ubiquitin-independent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process and cytosol, nucleus, proteasome core complex, beta-subunit complex localization"orf19.822 HSP21 ORF|Verified "Small heat shock protein; role in stress response and virulence; fluconazole-downregulated; induced in cyr1 or ras1 mutant; stationary phase enriched protein; detected in some, not all, biofilm extracts; Spider biofilm induced"orf19.2501 FLC1 ORF|Verified "Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc1; regulated by iron; macrophage-induced; mutant defective in filamentous growth; Spider biofilm induced"orf19.3788.1 RPL30 ORF|Uncharacterized "Ribosomal 60S subunit protein; pre-rRNA processing; pre-mRNA alternatively spliced to productive/unproductive transcripts; temp-regulated splicing; colony morphology-related regulation by Ssn6, Tup1, Nrg1 regulated; Spider biofilm repressed"orf19.5165 ORF|Uncharacterized Ortholog(s) have cytoplasm localization

Cluster 6

orf19.5855 MBP1 ORF|Verified "Putative component of the MBF transcription complex involved in G1/S cell-cycle progression; non-periodic mRNA expression; predicted, conserved MBF binding sites upstream of G1/S-regulated genes"orf19.4368 ORF|Uncharacterized Has domain(s) with predicted hydrolase activity and role in cellular processorf19.3235 ORF|Uncharacterized "Putative F-actin capping protein subunit alpha; possibly an essential gene, disruptants not obtained by UAU1 method"orf19.1360.1 ORF|Uncharacterized Putative adhesin-like proteinorf19.2725 ORF|Dubious Ortholog of Candida albicans WO-1 : CAWG_03525orf19.182 ORF|Uncharacterized "Ortholog(s) have rRNA (guanine-N1-)-methyltransferase activity, role in rRNA modification and endoplasmic reticulum, mitochondrion localization"orf19.1872 ORF|Verified Plasma membrane protein; repressed by nitric oxideorf19.1883 YCS4 ORF|Uncharacterized Putative condensin complex subunit; cell-cycle regulated periodic mRNA expressionorf19.5828 ORF|Uncharacterized "Ortholog(s) have pre-mRNA branch point binding activity, role in generation of catalytic spliceosome for first transesterification step, mRNA branch site recognition, mRNA cis splicing, via spliceosome and commitment complex localization"orf19.3334 RPS21 ORF|Uncharacterized Protein component of the small (40S) subunit; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; Spider biofilm repressedorf19.1628 LAP41 ORF|Verified Putative aminopeptidase yscI precursor; mutant is viable; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressedorf19.1105.2 PGA56 ORF|Verified "Regulator of sorbose utilization; putative GPI-anchor; hypha and cell wall regeneration induced; colony morphology-related gene regulation by Ssn6; induced by Tbf1, Hap43; Spider biofilm induced"orf19.2515 ORF|Uncharacterized ZZ-type zinc finger protein; rat catheter and Spider biofilm inducedorf19.2175 ORF|Uncharacterized Putative mitochondrial cell death effector; induced by nitric oxide; Spider biofilm induced; rat catheter biofilm repressedorf19.4476 ORF|Uncharacterized Protein with a NADP-dependent oxidoreductase domain; transcript induced by ketoconazole; rat catheter and Spider biofilm inducedorf19.7085 ORF|Uncharacterized Protein of unknown function; induced in core stress response; induced by cadmium stress via Hog1; oxidative stress-induced via Cap1; induced by Mnl1 under weak acid stress; macrophage-repressed; rat catheter and Spider biofilm inducedorf19.1567 ORF|Uncharacterized "Ortholog(s) have Rab guanyl-nucleotide exchange factor activity, phosphatidylinositol binding activity"orf19.2346 ORF|Uncharacterized "Putative protein of unknown function, transcription is positively regulated by Tbf1p"orf19.3022 ORF|Uncharacterized Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localizationorf19.7537 BNR1 ORF|Verified Formin; probable role in hyphal cytoskeletal polarity; synthetic lethality if Bnr1p and Bni1p are absentorf19.4907 ORF|Uncharacterized Putative protein of unknown function; Hap43p-repressed gene; increased transcription is observed upon fluphenazine treatment; possibly transcriptionally regulated by Tac1p; induced by nitric oxide; fungal-specific (no human/murine homologorf19.4176 ORF|Uncharacterized Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localizationorf19.4035 PGA4 ORF|Verified "GPI-anchored cell surface protein; beta-1,3-glucanosyltransferase with similarity to the A. fumigatus GEL family; transcript induced in RHE model of oral candidiasis; fluconazol-induced"orf19.4336 RPS5 ORF|Verified Ribosomal protein S5; macrophage/pseudohyphal-induced after 16 h; downregulated upon phagocytosis by murine macrophage; Hap43-induced; Spider biofilm repressedorf19.4630 CPA1 ORF|Uncharacterized "Putative carbamoyl-phosphate synthase subunit; alkaline repressed; rat catheter, Spider and flow model biofilm induced"orf19.6387 HSP104 ORF|Verified "Heat-shock protein; roles in biofilm and virulence; complements chaperone, prion activity in S. cerevisiae; guanidine-insensitive; heat shock/stress induced; repressed in farnesol-treated biofilm; sumoylation target; Spider biofilm induced"orf19.4357 ORF|Uncharacterized "Putative protein similar to S. cerevisiae Mgr3p, a subunit of the i-AAA protease supercomplex that degrades misfolded mitochondrial proteins"orf19.7116 ORF|Uncharacterized Protein of unknown function; transcript induced in RHE model of oral candidiasis; Spider biofilm repressedorf19.4530.1 ORF|Uncharacterized "Protein of unknown function; regulated by Nrg1, Tup1; Spider and flow model biofilm induced"orf19.2201 ORF|Uncharacterized "Ortholog(s) have ribosome binding activity, role in mitochondrial respiratory chain complex III assembly, positive regulation of mitochondrial translation and mitochondrial ribosome localization"orf19.2030 ORF|Verified "Plasma membrane-associated protein; induced in cyr1 or ras1 mutant; induced by hypoxia, ketoconazole and during growth in the mouse cecum; induced in oralpharyngeal candidasis; Spider biofilm induced"orf19.3366.1 ORF|Uncharacterized Protein of unknown function; Hap43-repressed geneorf19.1861 ORF|Uncharacterized Protein of unknown function; flow model biofilm induced

Cluster 7

orf19.109 ORF|Uncharacterized "Probable mitochondrial tyrosyl-tRNA synthetase, based on conservation in other fungi"orf19.4931 ORF|Uncharacterized "Putative tRNA-Cys synthetase; induced by alpha pheromone in SpiderM medium; ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage"orf19.3707 YHB1 ORF|Verified "Nitric oxide dioxygenase; acts in nitric oxide scavenging/detoxification; role in virulence in mouse; transcript activated by NO, macrophage interaction; Hap43, hypha repressed; mRNA binds She3"orf19.1701 RKI1 ORF|Uncharacterized "Ortholog(s) have ribose-5-phosphate isomerase activity, role in pentose-phosphate shunt, pyridoxine biosynthetic process and cytoplasm, nucleus localization"orf19.7021 GPH1 ORF|Verified "Putative glycogen phosphorylase; role in glycogen metabolism; regulated by Ssk1, Mig1, Tup1, Hap43; fluconazole-induced; localizes to cell surface of hyphae, not yeast; stationary phase enriched protein; Spider biofilm induced"orf19.4884 WOR1 ORF|Verified "Transcription factor (""master switch"") of white-opaque phenotypic switching; required to establish and maintain the opaque state; opaque-specific, nuclear; regulates its own expression; suggested role in regulation of adhesion factors"orf19.2947 SNZ1 ORF|Verified "Stationary phase protein; vitamin B synthesis; induced byyeast-hypha switch, 3-AT or in azole-resistant strain overexpressing MDR1; soluble in hyphae; regulated by Gcn4, macrophage; Spider biofilm induced; rat catheter biofilm repressed"orf19.3058 COQ6 ORF|Uncharacterized Ortholog(s) have role in ubiquinone biosynthetic process and mitochondrial inner membrane localizationorf19.4725 SWI6 ORF|Verified "Putative component of the MBF and SBF transcription complexes involved in G1/S cell-cycle progression; periodic mRNA expression, peak at cell-cycle G1/S phase"orf19.6581 ORF|Uncharacterized "Ortholog(s) have palmitoyltransferase activity, role in protein palmitoylation and endoplasmic reticulum localization"orf19.932 ORF|Uncharacterized "Putative aminophospholipid translocase (flippase); merged with orf19.2226 in Assembly 21; possibly an essential gene, disruptants not obtained by UAU1 method"orf19.5379 ERG4 ORF|Uncharacterized Protein similar to sterol C-24 reductase; shows Mob2p-dependent hyphal regulation; fluconazole-induced; caspofungin repressed; rat catheter biofilm repressedorf19.7401 ISW2 ORF|Verified Ortholog of S. cerevisiae Isw2; an ATPase involved in chromatin remodeling; required for chlamydospore formation; Hap43-induced gene; repressed by high-level peroxide stressorf19.2608 ADH5 ORF|Verified "Putative alcohol dehydrogenase; regulated by white-opaque switch; fluconazole-induced; antigenic in murine infection; regulated by Nrg1, Tup1; Hap43, macrophage repressed, flow model biofilm induced; Spider biofilm induced"orf19.4246 ORF|Verified Protein with similarity to S. cerevisiae Ykr070w; Tn mutation affects filamentation; Hog1-repressed; colony morphology-related gene regulation by Ssn6p; induced during cell wall regeneration; possibly essentialorf19.4602 MDH1-1 ORF|Uncharacterized Predicted malate dehydrogenase precursor; macrophage-induced transcript; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressedorf19.5348 TPS3 ORF|Uncharacterized "Predicted trehalose-phosphate synthase regulatory subunit; regulated by Efg1; regulated by Tsa1, Tsa1B under H2O2 stress conditions; flow model biofilm induced (reports differ)"orf19.1852 ORF|Uncharacterized Ortholog(s) have mitochondrion localizationorf19.6322 ARD ORF|Verified "D-arabitol dehydrogenase, NAD-dependent (ArDH); enzyme of D-arabitol and D-arabinose catabolism; D-arabitol is a marker for active infection in humans; rat catheter and Spider biofilm induced"orf19.5033 ORF|Uncharacterized "Ortholog(s) have Atg8 ligase activity, protein tag activity"orf19.7086 ORF|Uncharacterized "Ortholog(s) have protein transporter activity, role in transcription factor import into nucleus and cytosol, nuclear envelope localization"orf19.6757 GCY1 ORF|Verified Aldo/keto reductase; mutation confers hypersensitivity to toxic ergosterol analog; farnesol-repressed; stationary phase enriched protein; flow model biofilm induced; Spider biofilm repressedorf19.551 ORF|Uncharacterized "Ortholog of C. dubliniensis CD36 : Cd36_29980, C. parapsilosis CDC317 : CPAR2_204170, Candida tenuis NRRL Y-1498 : CANTEDRAFT_110235 and Debaryomyces hansenii CBS767 : DEHA2F17072g"orf19.3026 MAS1 ORF|Uncharacterized Putative mitochondrial processing protease; Hap43-repressed; transcript regulated by Nrg1; oxidative stress-induced via Cap1orf19.2863.1 ERV1 ORF|Uncharacterized "Predicted component of the mitochondrial intermembrane space (IMS), involved in protein import into mitochondrial intermembrane space"orf19.6877 PNG2 ORF|Verified "Putative peptide:N-glycanase; gene has variable numbers of 12-bp repeats; induced by caspofungin, ciclopirox olamine, ketoconazole or hypoxia; gene of core caspofungin response; Hap43-induced; Spider biofilm induced"

Cluster 8

orf19.1667.1 ORF|Uncharacterized "Ortholog(s) have role in mitochondrial respiratory chain complex IV assembly and mitochondrial intermembrane space, nucleus localization"orf19.1769 ORF|Uncharacterized "Ortholog(s) have G-protein beta/gamma-subunit complex binding, actin binding activity, role in positive regulation of transcription from RNA polymerase II promoter by pheromones, protein folding and cytoplasm localization"orf19.5533 ORF|Uncharacterized "Ortholog(s) have guanyl-nucleotide exchange factor activity, ubiquitin binding activity"orf19.3215 ORF|Uncharacterized Putative plasma membrane protein; in S. cerevisiae it is localized to the cell bud and mating projection membrane; repressed by alpha pheromone in SpiderM mediumorf19.4674.1 CRD2 ORF|Verified "Metallothionein; for adaptation to growth in high copper; basal transcription is cadmium-repressed; Ssn6 regulated; complements copper sensitivity of an S. cerevisiae cup1 mutant; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced"orf19.5648 ORF|Uncharacterized "Ortholog of C. dubliniensis CD36 : Cd36_40300, C. parapsilosis CDC317 : CPAR2_402190, Candida tenuis NRRL Y-1498 : cten_CGOB_00197 and Debaryomyces hansenii CBS767 : DEHA2F06160g"orf19.4067 FGR18 ORF|Verified Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growthorf19.6060 GCN20 ORF|Uncharacterized "YEF3-subfamily ABC family protein, predicted not to be a transporter"orf19.954 ORF|Uncharacterized Putative DnaJ-like chaperone; Hap43-repressed geneorf19.825 GCD7 ORF|Uncharacterized Putative translation initiator; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cellsorf19.3532 MRPL10 ORF|Uncharacterized Putative mitochondrial large subunit ribosomal protein; colony morphology-related gene regulation by Ssn6orf19.4633 ORF|Uncharacterized "Ortholog(s) have carbonyl reductase (NADPH) activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor activity and cytosol, nucleus, ribosome localization"orf19.4697 MDN1 ORF|Uncharacterized "Putative midasin, a very large dynein-related AAA-type ATPase; induced during the mating process"orf19.4097 ORF|Uncharacterized "Ortholog of C. dubliniensis CD36 : Cd36_23480, C. parapsilosis CDC317 : CPAR2_407050, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116822 and Debaryomyces hansenii CBS767 : DEHA2B02046g"orf19.2514 ORF|Uncharacterized Predicted methyltransferase; rat catheter biofilm inducedorf19.4355 ORF|Uncharacterized "Ortholog of C. dubliniensis CD36 : Cd36_29080, C. parapsilosis CDC317 : CPAR2_202490, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112323 and Debaryomyces hansenii CBS767 : DEHA2F19184g"orf19.1774 ORF|Uncharacterized Predicted dehydrogenase; transcript upregulated in an RHE model of oral candidiasis; virulence-group-correlated expression; Spider biofilm repressedorf19.7072 PEL1 ORF|Uncharacterized Predicted enzyme of mitochondrial phospholipid biosynthesis; rat catheter and flow model biofilm inducedorf19.5818 SUR2 ORF|Uncharacterized "Putative ceramide hydroxylase; predicted enzyme of sphingolipid biosynthesis; regulated by Tsa1, Tsa1B under H2O2 stress conditions; Spider and flow model biofilm induced"orf19.6936 RAD53 ORF|Verified "Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of cell cycle checkpoint; ortholog of S. cerevisiae Rad53p, protein kinase required for cell-cycle arrest in response to DNA damage"orf19.6625 ORF|Uncharacterized "Ortholog(s) have acetyltransferase activator activity, histone binding activity and role in double-strand break repair via nonhomologous end joining, nucleosome assembly, positive regulation of histone acetylation"

Cluster 9

orf19.4274 PUT1 ORF|Uncharacterized Putative proline oxidase; alkaline upregulated by Rim101; flow model biofilm induced; Spider biofilm inducedorf19.36.1 ORF|Uncharacterized Ortholog of C. parapsilosis CDC317 : CPAR2_104640 and Candida orthopsilosis Co 90-125 : CORT_0B05695orf19.1224 FRP3 ORF|Verified Putative ammonium transporter; upregulated in the presence of human neutrophils; fluconazole-downregulated; repressed by nitric oxide; Spider biofilm induced; rat catheter biofilm repressedorf19.2463 PRN2 ORF|Uncharacterized Protein similar to pirin; Hap43p-repressed geneorf19.2461 PRN4 ORF|Uncharacterized Protein with similarity to pirins; induced by benomyl treatment; flow model biofilm repressedorf19.7219 FTR1 ORF|Verified "High-affinity iron permease; required for mouse virulence, low-iron growth; iron, amphotericin B, caspofungin, ciclopirox, Hog1p, Sef1p, Sfu1p, and Hap43p regulated; complements S. cerevisiae ftr1 iron transport; Hap43p-repressed"orf19.5113 ADH2 ORF|Uncharacterized Alcohol dehydrogenase; soluble in hyphae; expression regulated by white-opaque switching; regulated by Ssn6; indued by Mnl1 in weak acid stress; protein enriched in stationary phase yeast cultures; Spider biofilm inducedorf19.5763 ORF|Uncharacterized Has domain(s) with predicted oxidoreductase activity and role in metabolic processorf19.1715 IRO1 ORF|Verified "Putative transcription factor; role in iron utilization, pathogenesis; both IRO1 and adjacent URA3 are mutated in strain CAI4; suppresses S. cerevisiae aft1 mutant low-iron growth defect; hyphal-induced; reports differ about iron regulation"orf19.4720 CTR2 ORF|Uncharacterized Putative low-affinity copper transporter of the vacuolar membrane; induced by nitric oxide; clade-associated gene expression; rat catheter and flow model biofilm inducedorf19.6926 CSC25 ORF|Verified Guanyl-nucleotide exchange factor; activator of Ras/adenylyl cyclase pathway; functional homolog of S. cerevisiae Cdc25p; commonly called Cdc25; transposon mutation affects filamentous growthorf19.742 ALD6 ORF|Uncharacterized Putative aldehyde dehydrogenase; stationary phase enriched protein; expression regulated upon white-opaque switch; rat catheter biofilm induced; rat catheter and Spider biofilm inducedorf19.6438 ORF|Uncharacterized "Ortholog(s) have serine C-palmitoyltransferase activity, role in sphingolipid biosynthetic process and SPOTS complex localization"orf19.4082 DDR48 ORF|Verified "Immunogenic stress-associated protein; filamentation regulated; induced by benomyl/caspofungin/ketoconazole or in azole-resistant strain; Hog1, farnesol, alkaline repressed; stationary phase enriched; Spider, flow model biofilm induced"orf19.1614 MEP1 ORF|Verified "Ammonium permease; Mep1 more efficient permease than Mep2, Mep2 has additional regulatory role; 11 predicted transmembrane regions; low mRNA abundance; hyphal downregulated; flow model biofilm induced"orf19.6769 ORF|Uncharacterized Ortholog(s) have cytoplasm localizationorf19.3234 OYE22 ORF|Uncharacterized Putative NADPH dehydrogenase; rat catheter biofilm inducedorf19.1441 ORF|Uncharacterized "Ortholog of C. dubliniensis CD36 : Cd36_16230, C. parapsilosis CDC317 : CPAR2_213950, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112720 and Debaryomyces hansenii CBS767 : DEHA2A01848g"

orf19.5862 AFP99 ORF|Uncharacterized Protein related to arginases; downregulated upon adherence to polystyrene; regulated by Gcn2p and Gcn4porf19.7349 CHS4 ORF|Verified "Activator of Chs3p chitin synthase; required for wild-type wall chitin content, but not for hyphal growth; mutant resistant to Calcofluor white; prenylation and 2 transmembrane segments predicted; functional homolog of S. cerevisiae Chs4p"orf19.6033 CMP1 ORF|Verified "Catalytic subunit of calcineurin (Ca[2+]-calmodulin-regulated S/T protein phosphatase); required for wild-type virulence, resistance to high pH, Na(+), Li(+), Mn(2+), and fluconazole tolerance; micafungin is fungicidal to null mutant"

Cluster 10

Cluster 11