organ on a chipcc.ee.ntu.edu.tw/~ultrasound/belab/midterm_oral... · organ on a chip don ingber,...
TRANSCRIPT
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Organ on a chip
Don Ingber, MD, PhD Founding Director, Wyss Institute at Harvard
Reportors: W.-C. Wang, T.-W. Chiang, M.-J. Yang
Group 4, Biomedical Engineering Lab
Department of Electrical Engineering
National Taiwan University
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Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
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Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
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Manufacturing
Process
- poly(dimethylsiloxane) (PDMS)
- tetrabutylammonium fluoride
- introduce
alveolarepithelial cells and
microvascular endothelial cells
into their respective channels
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Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
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Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
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Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
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Advantage • Observing information immediately
• Real time
• Whole procedure is viewable
• Allow to do Mechanical and Quantitative Analysis • Change the concentration of drugs instantaneously
• In drug testing, this chip shows us • Drug Toxicity
• Human Disease Model
• Drug Efficacy.
Replace current drug development model
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Outline
-Abstract
-Manufacture Procedure
-Organ Function
-Disease Model
-Conclusion
-Future Work
![Page 21: Organ on a chipcc.ee.ntu.edu.tw/~ultrasound/belab/midterm_oral... · Organ on a chip Don Ingber, MD, PhD Founding Director, Wyss Institute at Harvard Reportors: W.-C. Wang, T.-W](https://reader034.vdocument.in/reader034/viewer/2022042908/5f38c8e81f6b140a423d3834/html5/thumbnails/21.jpg)
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Future : Human body on a chip