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Orthopaedics and Trauma Queensland
A N N U A L R E P O R T 2 0 0 8
› AO BRisBANE sPiNE
REfERENcE cENTRE
› MEdicAL ENgiNEERiNg
› NORThsidE sPiNE
REsEARch gROUP
› ORThOPAEdic
REsEARch gROUP
› PAEdiATRic sPiNE
REsEARch gROUP
› REgENERATivE
MEdiciNE gROUP
› TRAUMA REsEARch gROUP
HeadingContents
inTrOducTiOn inside front
direcTOr’s message inside front
research and highlighTs › research Overview 1 › selected Project highlights 1
research FaciliTies › institute of health and Biomedical
innovation (ihBi) 4 › Faculty of Built environment and
engineering 4 › medical engineering research
Facility (merF) 4
highlighTs OF The Year 5
naTiOnal cOmPeTiTive granTs 7
OTher granTs 8
PuBlicaTiOns › Book chapters 10 › Journal articles 10 › guest editors 11 › international conference
Presentations 12 › australian/new Zealand
conference Presentations 12 › guest Presentations 14
sTaFF 15
adJuncT PrOFessOrial sTaFF 17
higher degree research sTudenTs › new students 18 › continuing students 18 › completions 19 › Overseas visiting students 19
awards, PriZes and cOmmuniTY service 20
acknOwledgemenTs inside back
fOR fURThER iNfORMATiON PhOne +61 7 3138 6000 Fax +61 7 3138 6030 email [email protected]/research/medical_device.jsp
iNTROdUcTiON
Orthopaedics and Trauma Queensland is an internationally recognised research group that
is developing into an international leader in research and education. it provides a stimulus
for research, education and clinical application within the international orthopaedic and
trauma communities.
Orthopaedics and Trauma Queensland develops and promotes the innovative use of
engineering and technology, in collaboration with surgeons, to provide new techniques,
materials, procedures and medical devices. its integration with clinical practice and strong links
with hospitals ensure that the research will be translated into practical outcomes for patients.
The group undertakes clinical practice in orthopaedics and trauma and applies core
engineering, modelling and clinical skills to challenges in medicine. The research is built on
a strong foundation of knowledge in biomedical engineering and incorporates expertise in
cell biology, mathematical modelling, human anatomy and physiology and clinical medicine
in orthopaedics and trauma. new knowledge is being developed and applied to the full
range of orthopaedic diseases and injuries, such as knee and hip replacements, fractures
and spinal deformities.
diREcTOR’s MEssAgE
welcome to the third Orthopaedics and Trauma Queensland
(O&TQ) annual report.
2008 was an exciting year with staff moving into the medical
engineering research Facility (merF) on the site of The Prince
charles hospital and the official opening on 16th september. merF
is already very busy running surgical skills workshops and the extra
research facilities are providing an impetus for accelerating research
activity in the group.
The research output of O&TQ continues to impress. in 2009 we are looking to develop our
international linkages and to investigate further funding avenues. in the first half of 2009
the group has continued to grow in numbers and research activity. Full details of these
activities will be provided in the 2009 annual report.
at the end of 2008 Professor dietmar w hutmacher took over as the medical device
domain leader in the institute of health and Biomedical innovation (ihBi), and associate
Professor clayton adam took over as the medical engineering Theme leader in the
Faculty of Built environment and engineering. These changes will provide us with a fresh
impetus to develop O&TQ into the future.
in addition, we have restructured O&TQ and i have pleasure in announcing that dr Peter
Boys, from the Queensland Orthopaedic research Trust has accepted the position of
chair of O&TQ. he will be leading our initiatives to position O&TQ both nationally and
internationally over the following year.
whilst i am standing down from some leadership positions i will still be intimately involved
in the activities of O&TQ. next year’s report will be led by Peter, clayton and dietmar and
i’m looking forward to the exciting prospects for the next few years.
Mark Pearcy Bsc, Phd, fiEAust, cPEng (Biomed)Professor of Biomedical engineering director, medical engineering research Facility
R e s e a R C H a n d H i g H l i g H t s [ 1 ]
Research and highlights
REsEARch OvERviEw
The research of Orthopaedics and Trauma
Queensland seeks to solve problems in a
broad range of areas, including:
sELEcTEd PROjEcT highLighTs
1. AO Brisbane spine Reference centre – Reducing secondary degeneration after spinal cord injury
The neurological damage from a spinal
cord injury is believed to be localised,
however it initiates a cascade of secondary
events which usually leads to extensive
and permanent paralysis. This secondary
damage begins with the disruption
of the blood – spinal cord barrier and
unleashes the body’s normal response
to tissue damage, inflammation. unlike
successful wound healing in other
tissues, inflammation in the spinal cord is
ongoing and can be observed for weeks
and months afterwards. This prolonged
inflammatory response is the catalyst for
secondary neurodegeneration and a major
reason for the limited repair response that
occurs naturally. in this ongoing work we
proposed that by early amplification of the
population and activation of inflammatory
cells, the inflammation would reach a
self limiting threshold and secondary
degeneration would not occur. we have now
shown that this is the case and Figure 1
below shows the difference between a
spinal cord where the inflammation has
been amplified (bottom) and one where it
has not (top). This work was recognised
by the spine society of australia research
award for 2008, and dr Ben goss was also
named runner up in the 2008 australian
society for medical research, Queensland
Premier’s award for senior Post-doctoral
medical researchers.
Figure 1. Images of two damaged spinal cords where the inflammation has been amplified (bottom) and one where it has not (top).
2. Medical Engineering – Probing the condition of cartilage during arthroscopy
a new quantitative arthroscopy system is
being developed to address the issues of
early stage detection of the causes of joint
degeneration and osteoarthritis in particular.
This device being developed by Professor
kunle Oloyede and Professor ross
crawford will be able to identify and
quantify the level of degradation of the
major components of articular cartilage.
The consequence of this capability will
be the elimination of subjectivity in the
visual assessment process which currently
limits the direct application of arthroscopic
evaluation to treatment.
The device will extend current grading
systems of the osteoarthritic condition to aid
treatment decisions, enabling the matching
of symptoms to surgical operations.
Furthermore, post-operative evaluation of
the healing process will be possible, leading
to the assessment of the effectiveness of
particular treatment methods.
Of significance is the inherent capacity of
this new device, the smarthroscope, to
categorise and quantify joint degeneration
in younger members of the population, so
that early intervention could be carried out.
The project will lead to potential reductions
in the need for extensive surgical
experience before effective diagnosis
and treatment decisions can be made.
Therefore the outcome will be beneficial to
regions of the world with limited surgical
expertise and facilities, such as developing
countries. more clinicians will be able
to participate in the treatment process
through quantitative diagnosis.
3. Northside spine Research group – Databases for clinical review of spine surgery procedures
The northside spine research group
is currently focused on developing
comprehensive clinical databases for a
range of spine surgery procedures to assess
the clinical efficacy of surgical treatments
for lumbar spinal disorders. Procedures
being assessed include: anterior lumbar
interbody fusion (aliF), transforaminal
lumbar interbody fusion (TliF), discectomy
(intervertebral disc removal), and
laminotomy/laminectomy procedures.
while the database development is
at an early stage, the potential for
improvement in clinical outcomes is
demonstrated in a current study of 78
patients undergoing spine fusion (TliF)
with a polyethylethylketone (Peek)
implant and bone morphogenetic protein
(BmP) to promote bony fusion. regular
post-operative assessment found early
complications in eight patients, two of
which were not linked with BmP. Fluid cyst
formation in the spinal canal in the region
of the posterior cage and the adjacent
› Biomaterials and bone substitutes
› cartilage biomechanics
› cell biomechanics › cell biology › clinical research › epidemiology › Fracture healing › Joint lubrication › mathematical
modelling › mechanical
testing
› Osteoarthritis › regenerative
medicine › spinal deformity › spinal disease › surgical
complications › surgical implants › Tissue
engineering › Tissue
mechanics › wound healing › Osteoporosis
[ 2 ] R e s e a R C H a n d H i g H l i g H t s
epidural space were seen on post-operative
magnetic resonance imaging (mri) in four
patients. no such complications were seen
in 33 patients who previously underwent
TliF using a similar technique but where
bone graft rather than BmP was used.
Preliminary results indicate that, after a
change of BmP dose, fusion rates and
outcomes in these patients were improved.
The change in BmP dose and its effect on
bony union is being investigated over the
longer term by reviewing fusion rates pre
and post procedural change.
4. Orthopaedic Research group – Femoral nails for the developing world
whilst intramedullary nailing is a commonly
accepted technique for lower limb fracture
fixation, the cost of nails can be prohibitive
in hospitals in developing nations. in these
institutions bone cement has found many
‘off label’ applications, that whilst effective
do not meet manufacturer’s guidelines.
The aim of this study was to examine the
biomechanics of one such application,
fracture fixation using a bone cement
intramedullary nail.
The experiment involved creating a broken
femur then fixing the fracture using a nail
made from antibiotic simplex bone cement.
intramedullary nails made from bone cement
were able to provide sufficient promise in
this situation to warrant further investigation
for their applicability as a low cost alternative
for use in developing countries (Figure 2).
Figure 2. Example of fracture fixation using bone cement
5. Paediatric spine Research group – Patient specific computer modelling of spinal deformity surgery
researchers in the Paediatric spine
research group are using computer
modelling techniques to assist surgeons
in better predicting surgical outcomes for
scoliosis patients. The computer models
are developed using a patient’s computed
tomography (cT) scans and include
representations for the bone geometry and
spinal soft tissues as well as the devices
implanted by the surgeon. These devices
include metal rods which are attached
to the patient’s spine with screws and
tightened to correct the spinal deformity.
By simulating the forces applied to the
patient’s spine both during and after
surgery, it is possible to predict stresses
and strains in the implant and spinal tissue.
using this information, possible overload
of the spine and implant materials can
be predicted and thus, post-operative
complications (such as screw loosening
or tissue damage) can be avoided. By
predicting the outcomes of surgical
procedures in individual patients before
they are carried out, this will provide
surgeons with a pre-operative planning
tool to reduce surgical complications
and improve patient outcomes following
scoliosis surgery (Figure 3).
Figure 3. Full spine computer model of a scoliosis patient with surgical implant attached. Screws (green) are embedded in the spinal bones, called vertebrae (purple) and when attached to a rod (green), they reduce the curved deformity.
6. Regenerative Medicine group – Establishment of large preclinical animal models for critical sized bone defect healing
in collaboration with the Orthopaedic and
Trauma research groups, Professor dietmar
hutmacher’s regenerative medicine group
is combining basic science with advanced
surgical techniques, to develop innovative
and translational (from bench to bedside)
bone tissue engineering technologies for
treating segmental bone defects.
The reconstruction of large bone segments
(Figure 4) remains a significant clinical
problem. large bone defects occur
mainly as a result of extensive bone
loss due to pathological events such
as trauma, inflammation, and surgical
treatment of tumours. Present therapeutic
approaches include the application of
bone graft transplants (autograft, allograft,
xenograft), as well as implants made of
different synthetic and natural biomaterials.
however, no existing therapy has been
proven to be fully satisfactory.
R e s e a R C H a n d H i g H l i g H t s [ 3 ]
The area of bone tissue engineering (which
has its main focus on the development
of bioactive materials) offers significant
potential for bone defect reconstruction.
To tackle major bone tissue engineering
problems however, it is essential that
animal models, fixation devices, surgical
procedures and measurement methods
are standardized to allow the accumulation
of a reliable data pool as a base for further
research directions.
in order to study a tissue engineered
construct it is necessary to develop an
animal model which represents the clinical
situation as closely as possible. Based on a
recent review by the regenerative medicine
group (reichert Jc et al, 2009 Biomaterials
30:2149–2163), 7–9 year old sheep
are considered to be the most suitable
animals for use in an experimental model
of bone defect healing. in mature sheep,
bone consists principally of primary bone
structure in comparison with the largely
secondary, haversian bone composition of
humans. secondary osteonal remodelling
in sheep only takes place at an average
age of 7–9 years. Therefore, only older
sheep have a bone biology that is similar to
that in humans.
multidisciplinary approaches are essential
to realise the vision of treating large
segmental tibia defects by using novel
scaffolds in combination with either cells
or growth factors, and the regenerative
medicine group has assembled a team of
engineers, basic scientists and surgeons,
with the aim of allowing australia to
become a leading player in this exciting
and competitive field.
Figure 4: Implantation of a medical grade PCL-TCP scaffold loaded with 3 mg of BMP-7 into a critical sized bone defect of a sheep tibia
7. Trauma Research group – The influence of surgical approach on fracture healing outcomes
The Trauma research group has recently
completed an animal study in sheep to
determine whether the surgical approach
– the way in which a fixation implant is
applied to the fractured bone – has any
influence on the healing outcome of bone
fractures (Figure 5). minimally invasive
(so-called ‘keyhole’) surgery has become
a popular method to apply fracture fixation
plates, with fewer fractures treated by a
traditional open reduction internal fixation,
where the fracture site is exposed along
the entire length of the implanted fracture
fixation plate. however, while the newer
method offers obvious cosmetic (smaller
scars) and other potential advantages
(e.g. reduced infection risk), it comes at
the cost of increased exposure to x-ray
radiation and is generally more demanding
for the surgeon.
while the complete evaluation of the
experiments is still ongoing, initial results
indicate advantages for fractures treated in
a minimally invasive fashion. The minimally
invasive surgical approach resulted in less
damage to the soft tissues surrounding
the fracture. This was demonstrated by
analysis of clinical markers for muscle
injuries in the circulating blood. mechanical
testing of the healing bone, which is a
measure of healing outcome, showed an
earlier recovery of strength and stiffness
for the fractures treated with the minimally
invasive approach.
These first results demonstrate that
minimally invasive surgery for the internal
fixation of bone fractures, despite being
more demanding for the surgeon, leads
to outcomes that are comparable, if
not better, than those achieved using
traditional surgical methods. These results
have direct clinical implications and will
further aid the development of improved
surgical methods for the application of
fracture fixation implants.
Figure 5. Dr Martin Wullschleger (right) and Dr Sadahiro Sugiyama (left) operating during the sheep study to compare minimally invasive and open approaches for fracture fixation.
[ 4 ] R e s e a R C H f a C i l i t i e s
Research facilities
iNsTiTUTE Of hEALTh ANd BiOMEdicAL iNNOvATiON (ihBi)
QUT Kelvin grove campus › laboratories for cell culture, mechanical and materials Testing, Polymer chemistry, Tissue
mechanics, Bone and cartilage instrumentation, histology and micro-computed Tomography › mechanical and electronics workshop › seminar room
fAcULTy Of BUiLT ENviRONMENT ANd ENgiNEERiNg
QUT gardens Point campus › cell culture and mechanical Testing laboratories › rapid Prototyping Facility › six axis spine testing robot › nanoindentation (umis 2000) › seminar room
MEdicAL ENgiNEERiNg REsEARch fAciLiTy (MERf)
The Prince charles hospital › Operating Theatre › anatomical skills laboratory › materials Testing, cell culture, histology, Physiology and general project laboratories › seminar room
Computer simulations are used to quantify and optimise the anatomical fit of fracture fixation implants, in this case an intramedullary nail for tibia fractures.
H i g H l i g H t s o f t H e y e a R [ 5 ]
Highlights of the year
fAcTs ANd figUREs
86 staff
40 postgraduate students, including ten new postgraduate students and six postgraduate completions
$3 million research income
2 book chapters, 42 journal papers, 17 international conference presentations, 29 australian/new Zealand conference presentations
significant international links continued
MEdicAL ENgiNEERiNg REsEARch fAciLiTy BEgiNs OPERATiON › eight Queensland university of
Technology (QuT) staff › Four Queensland health (Qh) staff based
at the facility › Occupancy from February 2008 › Official Opening on 16 september 2008
Official Opening of MERfOn 16 september 2008 the medical
engineering research Facility (merF)
was officially opened by the state health
minister, the hon stephen robertson.
(Figures 6 and 7).
Figure 6. MERF at sunset
merF is a $10.7 million research and
training facility located in the grounds of
The Prince charles hospital in chermside,
Brisbane. it aims to lead australia in
orthopaedic, critical care and artificial
organ research. The medical engineering
research Facility has been funded by a
Queensland government smart state
Facilities grant of $5 million in addition to
$4.15 million from QuT.
The Prince charles hospital provided
the land as well as equipment and staff
support. Funding and equipment was also
provided by industry partners, medtronic
sofamor danek and stryker, each of whom
contributed significant cash and in-kind
support in the form of equipment.
The state-of-the-art facility offers operating
theatres, cell culture laboratories, materials
testing laboratories, mechanical and
electrical workshops and teleconferencing
technology which can link the centre to
the world.
Figure 7: QUT Vice Chancellor, Prof Peter Coaldrake (left) with Prof Ross Crawford (centre) and Prof Mark Pearcy (right) at the MERF opening.
visiT TO ihBi By ThE swiss AMBAssAdOR – dR dANiEL wOKER
The swiss ambassador to australia, dr daniel woker, visited ihBi on 21 October 2008
(Figure 8). dr woker was presented with an overview of the research activities of O&TQ, whose
members already have significant links to swiss research institutions, universities and industry.
dr woker will use his impressions to raise awareness of the strong research programs in
Queensland and australia at swiss universities and in industry, and will explore ways to foster
the development of further collaborative links between the two countries.
Figure 8. Swiss ambassador to Australia, Dr Daniel Woker (4th from right) with QUT research staff.
[ 6 ] H i g H l i g H t s o f t H e y e a R
OPTOTRAK MOTiON TRAcKiNg sysTEM
Thanks to the generous support of the
Queensland Orthopaedic research Trust,
together with funds from Queensland
university of Technology, O&TQ
researchers have been able to purchase an
Optotrak which incorporates specialised
sensor technology and sophisticated
optics to measure and track 3d motion
and position with high resolution. Figure
9 shows the Optotrak being used to
measure vertebral motions of a calf spine
and ribcage during biomechanical testing
of scoliosis correction implants in QuT’s
six-axis testing robot.
Figure 9. Biomechanical testing of a spine with Optotrak markers attached to the spinous processes to measure motion during the test.
QUT sMART TRAiN
The QuT smart Train set off from ipswich
in may 2008, to travel throughout the
state of Queensland for six weeks, with its
final week spent in Brisbane. all faculties
at QuT joined forces to create another
exciting and worthwhile experience for the
rural and regional communities around
Queensland. it is one of the state’s largest
community outreach programs, having
hosted over 90 000 visitors to date. One of
the four carriages featured O&TQ research
activities and games including ‘Professor
crawford’s bone quiz’, and an interactive
‘spine surgery game’ which both proved to
be extremely popular.
a smart Train event on the Toowoomba
platform was combined with the launch
of the mater children’s hospital annual
fundraiser, ‘5 k’s for kids’. The Paediatric
spine research group were featured on
the Toowoomba platform representing
the successful collaborative partnership
between mater clinicians and QuT
researchers (Figure 10).
Figure 10. Assoc Prof Clayton Adam at the 2008 QUT Smart Train and Mater Foundation Toowoomba platform event.
Top right: Research Assistant Maree Izatt with scoliosis patient Shuang Hu.
Centre right: QUT IHBI Fundraising Manager Anna Herbert with Qld Rail representative.
Bottom right: Mater Foundation Director Nigel Harris with Qld School Children.
n a t i o n a l C o m p e t i t i v e g R a n t s [ 7 ]
national competitive grants
gRANT arc discovery grant
TiTLE Patient-specific biomedical modelling for improved treatment of spinal deformity
chiEf iNvEsTigATORs m Pearcy, c adam, J evans, g askin
fUNdiNg 2006–2008, $342 680
gRANT arc discovery grant
TiTLE engineering articular cartilage with zonal structure and function
chiEf iNvEsTigATORs d hutmacher, T klein, J malda, r sah
fUNdiNg 2007–2011, $523 934aPd Travis klein, $235 944
gRANT arc discovery grant
TiTLE Bilayered and growth factor-loaded composite scaffolds for the guided bi-differentiation of bone marrow mesenchymal stem cells.
chiEf iNvEsTigATORs x miao, Y xiao, r crawford
fUNdiNg 2008–2010, $255 000
gRANT arc linkage grant
TiTLE development of a prothrombogenic bone graft substitute
chiEf iNvEsTigATORs r crawford, m schuetz, a stemberger, B goss, B scott
fUNdiNg 2006–2008, $184 000
gRANT arc linkage grant
TiTLE understanding the biomechanical effects of fixation strategies to improve the technology of fracture management
chiEf iNvEsTigATORs m schuetz, s mishra, g chen, s Perran
fUNdiNg 2007–2010, $280 000
gRANT nhmrc development grant
TiTLE The next generation of Biomaterials; in vivo assessment of lumbar spine fusion biodegradable interbody cages
chiEf iNvEsTigATORs B goss, c lutton
fUNdiNg 2008–2010, $82 500
gRANT nhmrc development grant
TiTLE development of a smart arthroscopy system and prototype probe for joint tissue
chiEf iNvEsTigATORs a Oloyede, r crawford
fUNdiNg 2008–2010, $212 375
gRANT nhmrc australia-china exchange Fellowship
TiTLE development of gene-activated scaffolds as bone bioreactor for bone regeneration and osseointegration
chiEf iNvEsTigATORs Y Zhang, Y xiao
fUNdiNg 2008–2010, $215 000
[ 8 ] o t H e R g R a n t s
other grants
gRANT Queensland department of state development, smart state Fellowship
TiTLE development and characterisation of an osteoinductive polymeric bone graft substitute material for use in orthopaedic surgery
chiEf iNvEsTigATORs B goss
fUNdiNg 2006–2008, $150 000
gRANT wesley research institute
TiTLE Prevention of bacterial bone infections in mice with implant coatings for delivery of antibiotics, demonstrated by in vivo biophonic imaging
chiEf iNvEsTigATORs m schuetz, r steck, d mcmillan, B goss, s sommerville, a stemberger
fUNdiNg 2007–2008, $52 000
gRANT The Princess alexandra hospital Foundation
TiTLE health status and economic outcomes of critically ill trauma patients
chiEf iNvEsTigATORs l aitken, w chaboyer, m schuetz, e kendell, c Joyce
fUNdiNg 2008, $50 000
gRANT synthes
TiTLE morphology database for fracture modelling, implant design & optimisation
chiEf iNvEsTigATORs B schmutz, m schuetz
fUNdiNg 2008, $88 000
gRANT ihBi early career researcher
TiTLE evaluation of an implantation sensor to monitor pressure, oxygen tension and temperature in vivo over extended periods during bone regeneration
chiEf iNvEsTigATORs d epari
fUNdiNg 2008–2009, $9 500
gRANT statewide Trauma clinical network
TiTLE a reference Process model for multi-Trauma Patients
chiEf iNvEsTigATORs s clemens, m rosemann, m schuetz, m sinnott, B lowe
fUNdiNg 2008–2010, $106 000
gRANT statewide Trauma clinical network
TiTLE development of an integrated Trauma management system for head injury
chiEf iNvEsTigATORs g chattopadhyay, s mishra, s rashford, m schuetz, J kemsley, s halder, Y Toft
fUNdiNg 2008–2010, $118 000
gRANT department of education, science and Training international science linkages, australia – china fund for science and Technology co-operation
TiTLE developing tissue engineered product for clinical application using a model of temporomandibular joint disorders
chiEf iNvEsTigATORs Y xiao, r crawford, x miao
fUNdiNg 2008, $45 000
gRANT royal australasian college of surgeons Fellowship 2007–2008
TiTLE Benchmarking trauma care performance in a tertiary hospital in Queensland to european trauma centres: using the european registry as a model
chiEf iNvEsTigATORs m schuetz, l aitken, B Boullion, r lefering, T davey
fUNdiNg 2007–2008, $50 000
o t H e R g R a n t s [ 9 ]
gRANT Prostate cancer Foundation of australia grant
TiTLE application of a human bone engineering platform to an in-vivo prostate cancer model
chiEf iNvEsTigATORs d hutmacher, T klein, J reichert
fUNdiNg 2008, $395 000
gRANT australian Orthopaedic association
TiTLE Tissue engineering as a potential approach for the treatment of osteonecrosis
chiEf iNvEsTigATORs r crawford, x miao, Y xiao
fUNdiNg 2008, $32 261
gRANT aO research Foundation
TiTLE effect of surgical approach on fracture healing
chiEf iNvEsTigATORs m wullschleger, m schuetz, k ito
fUNdiNg 2005–2008, $130 000
gRANT marian and eh Flack Trust
TiTLE improving treatment outcomes for children with scoliosis: practical use of computer modelling
chiEf iNvEsTigATORs c adam
fUNdiNg 2008, $25 000
[ 1 0 ] p u b l i C a t i o n s
BOOK chAPTERs
1. gadomski a, kruszewska n, santamaria-holek k, uher JJ, Pawlak Z, Oloyede a, Pechkova e, nicolini c. can modern statistical mechanics unravel some practical problems encountered in model biomatter aggregations emerging in internal and external-friction conditions? Statistical Mechanics Research. nOva science Publishers, ed. Byung-soo kim, 2008, isBn: 978-1 60456-029-9.
2. miao x, gorring n. Nanoceramics and nanoceramic composites for biomedical applications. in Handbook of Nanoceramics and their based Nanodevices, eds. Tseung-Yuen Tseng and hari singh nalwa, american scientific Publishers, January 2008, isBn: 1-58883-114-0.
jOURNAL ARTicLEs
1. adam cJ, askin gn, Pearcy mJ. gravity-induced torque and intravertebral rotation in idiopathic scoliosis. Spine. 2008; 33:e30-e37.
2. Beldiman m, xiao Y, crawford r, Oloyede a. cell response in mixtures of surfactant-culture medium – towards a systemic approach to cell-based treatments for focal osteoarthritis. Biosystems. 2008; 94:209–14.
3. Beldiman m, xiao Y, crawford rw, Oloyede a. cell response in mixtures of surfactant-culture medium – towards a systemic approach to cell-based treatments for focal osteoarthritis. Biosystems. 2008; 94:209–214.
4. Berndt c, ganko a, whitehouse sl, crawford rw. heterotopic ossification within an arthroscopic portal after uneventful partial meniscectomy. Knee. 2008; 15:416–18.
5. Blom aw, rogers m, Taylor ah, Pattison g, whitehouse sl, Bannister gc. dislocation following total hip replacement. The Avon experience. Ann R Coll Surg Engl. 2008; 90:658–662.
6. Brown cP, hughes sw, crawford rd, Oloyede a. joint laminate degradation assessed by reflected ultrasound from the cartilage surface and osteochondral junction. Phys Med Biol. 2008; 53:4123–35.
7. Brown cP, crawford rw, Oloyede a. in search of a parameter to distinguish viable from non-viable articular cartilage – indentation and ultrasound studies. Advanced Materials Research. 2008; 32:223–228.
8. chen Y, dong Z, miao x. The effects of yttria-stabilised zirconia on the properties of the fluorine – substituted hydroxyapatite ceramics prepared by pressureless sintering. Journal of Biomimetics, Biomaterials and Tissue Engineering. 2008; 1:57–68.
9. chen Z, ekaputra a, gauthaman k, adaikan P, Yu h, hutmacher d. in vitro and in vivo analysis of co-electrospun scaffolds made of medical grade poly (epsilon-caprolactone) and porcine collagen. J Biomaterials Sci Polym Ed. 2008; 19:693–707.
10. conroy Jl, whitehouse sl, graves se, Pratt nl, ryan P, crawford rw. Risk factors for revision of early dislocation in total hip arthroplasty. J arthroplasty. 2008; 23:867–872.
11. davies mw, dunster kr, wilson k. gas exchange during perfluorocarbon liquid immersion. Life support for the ex utero fetus. Med Hypotheses. 2008; 71:91–8.
12. ekaputra a, Prestwich g, cool s, hutmacher d. combining electrospun scaffolds with electrosprayed hydrogels leads to three-dimensional cellularisation of hybrid constructs. Biomacromolecules. 2008; 9:2097–2103.
13. Fan w, crawford r, xiao Y. structural and cellular differences between metaphyseal and diaphyseal periosteum in different aged rats. Bone. 2008; 42:81–89.
14. gadomski a, Pawlak Z, Oloyede a. directed ion transport as virtual cause of some facilitated friction-lubrication mechanism prevailing in articular cartilage: A hypothesis. Tribology Letters. 2008; 30:83–90.
15. hay d, izatt m, adam c, labrom r, askin g. The use of fulcrum bending radiographs in anterior scoliosis correction: a consecutive series of 90 patients. Spine. 2008; 33:999–1005.
16. hutmacher d, Bowlin g. Nano-fiber scaffold science and tissue engineering. J Biomaterials Sci Polym Ed. 2008; 19:541–542.
17. hutmacher d, singh h. computational fluid dynamics for improved bioreactor design and 3d culture. Trends Biotechnol. 2008; 26:166–172.
18. krebs J, Ferguson s, hoerstrup s, goss B, haeberli a, aebli n. influence of bone marrow fat embolism on coagulation activation in an ovine model of vertebroplasty. J Bone Joint Surg Am. 2008; 90:349–356.
19. lam c, savalani m, Teoh s, hutmacher d. dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: accelerated versus simulated physiological conditions. Biomed Mater. 2008; 3:034108.
20. lee wcc, doocey Jm, Branemark r, adam, cJ, evans Jh, Pearcy mJ, Frossard la. fE stress analysis of the interface between the bone and an osseointegrated implant for amputees – implications to refine the rehabilitation programme. Clinical Biomechanics. 2008; 23:1243–50.
publications
p u b l i C a t i o n s [ 1 1 ]
21. little JP, Pearcy mJ, adam cJ. Are coupled rotations in the lumbar spine largely due to osseoligamentous anatomy? A modelling study. Computer Methods in Biomechanics and Biomedical Engineering. 2008; 11:95–103.
22. lutton c, goss B. caring about microenvironments. Nature Biotechnology. 2008; 26:613–614.
23. miao x. Modification of porous alumina ceramics with bioinert and bioactive glass coatings. Advanced Medicals Research. 2008; 32:211–214.
24. miao x, Tan dm, li J, xiao Y, crawford r. Mechanical and biological properties of hydroxyapatite/tricalcium phosphate scaffolds coated with poly(lactic-co-glycolic acid). Acta Biomater. 2008; 4:638–645.
25. Oloyede a, gudimetla P, chen a, crawford r. in vitro reversal of the load-bearing properties of lipid-depleted articular cartilage following exposure to phospholipid surfactant solutions. Clinical Biomech. 2008; 23:1200–1208.
26. Pawlak Z, crawford rw, Oloyede a. hypothetical model of hydrophilic lubrication in synovial joints. Australian Journal of Mechanical Engineering. 2008; 6:21–27.
27. Pawlak Z, kotynska J, Figaszewski Za, gadomski a, gudaniec a, Oloyede a. A biochemical model for characterising the surface-active phospholipid bilayer of articular cartilage relative to acid-base equilibrium. Archives of Material Science and Engineering. 2008; 29:24–29.
28. Pawlak Z, Oloyede a. conceptualisation of articular cartilage as a giant reverse micelle: A hypothetical mechanism for joint biocushioning and lubrication. Biosystems. 2008; 94:193–201
29. Pawlak Z, Pai r, Bayraktar e, kaldonski T, Oloyede a. Lamellar lubrication in vivo and vitro: friction testing of hexagonal boron nitrade. Biosystems. 2008; 94:202–208.
30. rider d, dombrowski c, sawyer a, ng g, leong d, hutmacher d, nurcombe v, cool s. Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells. Stem Cells. 2008; 26:1598–1608.
31. schmutz B, reynolds k, slavotinek J. customisation of a generic 3d model of the distal femur using diagnostic radiographs. Journal of Medical Engineering and Technology. 2008; 32:156–161.
32. schmutz B, wullschleger me, kim h, noser h, schuetz ma. fit assessment of anatomical plates for the distal medial tibia. Journal of Orthopaedic Trauma. 2008; 22(4):258–263.
33. schuetz m. Australien: Trauma management in ‘down under’. Deutsche Gesellschaft für Unfallchirurgie – Mitteilungen und Nachrichten. 2008; 30:81–83.
34. schuetz m. clinical experience with locking plates – a review of the last decade. Japanese Society for Fracture Repair. 2008; 30:13:40–14:40
35. singh s, Jones BJ, crawford r, xiao Y. characterisation of a mesenchymal-like stem cell population from osteophyte tissue. Stem Cells and Development. 2008; 17:245–254.
36. Tan dmF, miao x, li l, xiao Y, crawford r. characterization of calcium phosphate cement-derived hydroxyapatite scaffolds with a PLgA-bioactive glass compositing coating. Journal of Biomimetics, Biomaterials and Tissue Engineering. 2008; 1:99–107.
37. wei x, wu l, ling J, liu l, liu s, liu w, li m, xiao Y. differentially expressed protein profile of human dental pulp cells in early process of odontoblast-like differentiation in vitro. Endondotics. 2008; 34:1077–1084.
38. whitehouse s, crawford r, learmonth i. validation for the reduced western Ontario and McMaster Universities Osteoarthritis index function scale. J Orthop Surg (Hong Kong). 2008; 16:50–53.
39. xiao Y, Peng h, mao x, whittaker a, crawford r. Novel synthetic bio-mimic polymers for cell delivery. Journal of Advanced Materials Research. 2008; 32:215–222.
40. Zeugolis d, khew s, Yew e, ekaputra a, Tong T, Yung l, hutmacher d, sheppard c, raghunath m. Electro-spinning of pure collagen nano-fibres – just an expensive way to make gelatine? Biomaterials. 2008; 29:2293–2305.
41. Zhao Y, sugiyama s, miao x. Nanoceramics for blood borne virus removal. Expert Review of Medical Devices. 2008; 5:395–405.
42. Zhou Y, hutmacher d, sai-lim v, Zhou Z, woodruff m, lim T. Osteogenic and adipogenic induction potential of human periodontol cells. J Periodontol. 2008; 79:524–534.
gUEsT EdiTORs
1. hutmacher dw, Bowlin gl. Foreword. Journal of Biomaterials Science, Polymer Edition, 2008; 19:541–2.
2. Pearcy mJ, adam cJ, Thompson r, wilcox r. guest editors for special issue current concepts and clinically significant outcomes of recent research into spinal mechanics. Proceedings of the Institution of Mechanical Engineers, Part H, Journal of Engineering in Medicine 2008; 222:1–248.
[ 1 2 ] p u b l i C a t i o n s
iNTERNATiONAL cONfERENcE PREsENTATiONs
1. chen g, Pearcy m, schuetz m, steck r. Numerical investigations of effects of plate fixation on nutrition supply to bone cortex. 54th Annual Meeting of the Orthopaedic Research Society. san Francisco, usa. 2–5 march 2008.
2. chen g, schmutz B, steck r, Pearcy m, wullschleger m, wilson c, schuetz m. Predicting the fatigue life of internal fracture fixation plates. 16th Congress of the European Society of Biomechanics. lucerne, switzerland. 6–9 July 2008
3. epari d. Experimental models of fracture repair. International Symposium 2008 Biomechanics and Biology of Bone Healing. Berlin, germany. 15–17 may 2008.
4. epari d, schell h, lineau J, duda g. intra-callus pressure and oxygen tension during normal bone healing in the sheep tibia. 54th Annual meeting of the Orthopaedic Research Society. san Francisco, usa. 2–5 march 2008.
5. gaddum n. Passive control of a Rotary Bivad; An experimental and numerical investigation. 16th Congress of the International Society for Rotary Blood Pumps. houston, Texas, 22–24 October 2008.
6. knippels i, kidd l, Forwood m, schuetz m, steck r. characterisation of rat ulna compression model using microcT and finite Element calculations. 11th Biennial Conference of the International Society for Fracture Repairs (ISFR). lake Tahoe, usa. 13–16 July 2008
7. little JP, adam cJ, evans Jh, askin gn, Pearcy mJ. Patient-specific soft tissue properties for Ais patients: a finite element study. 8th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering. Porto, Portugal 27 Feb–1 march 2008.
8. mcdonald k, little J, Pearcy m, adam cJ. Relative roles of cortical and trabecular thinning in reducing osteoporotic vertebral body stiffness: a modelling study. 13th International Conference on Biomedical Engineering. singapore. 3–6 december 2008.
9. mcdonald k, little JP, Pearcy mJ, adam cJ. Relative roles of cortical and trabecular thinning in reducing osteoporotic vertebral body stiffness: A modelling study. 13th International Conference on Biomedical Engineering (ICBME). singapore, 3–6 december 2008.
10. nijboer J, wullschleger m, nielsen s, mcnamee a, lefering r, ten duis h, schuetz m. Benchmarking trauma care performance of a tertiary hospital in Queensland to European Trauma centres: Using the german Trauma Registry as a model. German Conference for Orthopaedic and Trauma Surgery (DGU) Berlin, germany 22–25 October 2008.
11. noser h, heldstab T, schmutz B, kamer l. Accuracy and validation of processing steps for creating cT-based 3d Bone Models. Congress of Computer Assisted Radiography and Surgery (CARS2008). Barcelona, spain, 25–28 June 2008.
12. Pawlak Z, Pai r, Bayraktar e, kaldonski T, Oloyede a. Lamellar lubrication in vivo and vitro: friction testing of h-BN. 8th Asia-Pacific Conference on Materials Processing. Guilin-Guangzhou, china 15–20 June 2008.
13. schmutz B, volp a, momot k, schuetz ma. Using MRi for the imaging of long bones: first experiences. 16th Congress of the European Society of Biomechanics. lucerne, switzerland. 6–9 July 2008
14. steck r, gregory l, minehara h, wullschleger m, schuetz m. Three-dimensional visualisation of callus geometry in new murine fracture model. 11th Biennial Conference of the International Society for Fracture Repairs (ISFR). lake Tahoe, usa. 13–16 July 2008
15. shillington m, adam cJ, labrom rd, askin gn. A biomechanical investigation of anterior vertebral stapling. 13th International Conference on Biomedical Engineering (ICBME). singapore, 3–6 december 2008.
16. steck r, mcmillan d, goss B, rosenzweig n, schuetz m. Polymeric implant coatings with incorporated antibiotics inhibit bacterial growth and are scratch resistant. German Conference for Orthopaedic and Trauma Surgery (DGU). Berlin, germany. 22–25 October 2008.
17. sugiyama s. Effects of increased ambient temperature during ivM and/or ivf on the in vitro development of bovine zygotes. Royon International Twin Conference. Tehran, iran. 27–29 august 2008.
AUsTRALiAN/NEw ZEALANd cONfERENcE PREsENTATiONs
1. cordell-smith J, adam c, izatt m, labrom r, askin g. The effect of bone graft type on fusion rates following endoscopic anterior scoliosis correction. Spine Society of Australia Annual Scientific Meeting. adelaide, australia. 18–20 april 2008.
2. cordell-smith J, izatt m, adam c, labrom r, askin g. computed Tomography evaluation of axial vertebral derotation in endoscopic anterior instrumentation for scoliosis. Spine Society of Australia Annual Scientific Meeting. adelaide, australia. 18–20 april, 2008
p u b l i C a t i o n s [ 1 3 ]
3. goss B, lutton c, Young w, mackay-sim a, meedeniya a. Reduction of secondary degeneration after spinal cord injury by acute delivery of vascular growth factors. Spine Society of Australia Annual Scientific Meeting. adelaide, australia. april 2008
4. ibrahim s, chen g, schmutz B, mishra s, steck r, epari d, schuetz m. Relationship between configuration of screws and stress in an internal fracture fixation plate. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.
5. izatt mT, adam cJ, labrom rd, askin gn. clinical aspects of endoscopic anterior scoliosis surgery. Adelaide Centre for Spinal Research – Spinal Research Symposium VI. adelaide, australia, 19–21 august 2008.
6. king B, wullschleger me, mishra s, schuetz ma, schmutz B. volumetric analysis of the space between bone surfaces and fracture fixation plates using 3d computer models. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.
7. lee a, anderson P, sawker r, moore a, Forwood m, steck r, morris h, O’loughlin P. short-term vitamin d deficiency causes cancellous bone loss without changes to either cortical bone volume or mechanical strength in the rat tibia. 18th Annual Scientific Meeting of the ANZBMS. melbourne, australia. 28–30 august 2008.
8. little P, adam c. The effect of soft tissue stiffness on spinal flexibility: A finite element study. Spine Society of Australia Annual Scientific Meeting. adelaide, australia. 18–20 april, 2008.
9. mayo a, adam cJ, labrom rd, askin gn. A biomechanical study of top screw pullout in anterior scoliosis correction. 15th International Meeting on Advanced Spine Techniques (IMAST). hong kong, 8–11 July 2008.
10. mohd radzi s, rathnayaka k, Pratap J, mishra s, schuetz ma, schmutz B. The effects of cT convolution kernels on the geometry of 3d bone models. 14th Annual Scientific Meeting, Australian & New Zealand Orthopaedic Research Society. Brisbane, australia, 17–18 november 2008.
11. rathnayaka k, schmutz B, sahama T, schuetz m. Effects of image segmentation methods on the accuracy of long bone 3d reconstructions. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.
12. shillington m, adam c, labrom r, askin g. The biomechanical effects of thoracic spine stapling. Spine Society of Australia Annual Scientific Meeting. adelaide, australia. 18–20 april 2008.
13. shillington m, adam cJ, labrom rd, askin gn. Anterior vertebral stapling for the fusionless correction of scoliosis: changes in motion segment stiffness following staple insertion and measurement of staple loading during movement. Australian and New Zealand Orthopaedic Research Society (ANZORS) 14th Annual Scientific Meeting. Brisbane, 16–21 november 2008.
14. schuetz m. development of a comprehensive trauma system in Queensland–benchmarking trauma care performance in a tertiary hospital in Queensland to European trauma centres. 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). hobart, australia. 12–15 October 2008.
15. schuetz m. Biomechanics of fracture healing–do we know how to treat simple fractures? 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). Hobart, Australia. 12–15 October 2008.
16. schuetz m. clinical experience with locking plates–a review of the last decade. 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). hobart, australia. 12–15 October 2008.
17. schuetz m. Animal injuries, horse kicks. Swan XVI Conference, Liverpool Hospital. sydney, australia. 25–26 July 2008.
18. schuetz m. Principals of locking plates and peri-articular plates. AOA-COE Conference. melbourne, australia. 6–8 august 2008.
19. schuetz m, epari d, chen g, schmutz B, steck r. Biomechanics of fracture healing. 5th Clare Valley Bone Meeting. adelaide, australia. 30 march–2 april 2008.
20. schmutz B, volp a, momot k, schuetz m. Using MRi for the imaging of long bones: first experiences. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.
21. schmutz B, wullschleger m, steck r, schuetz m. Periarticular implants–Optimisation of plate design with computer modelling. 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). hobart, australia. 12–15 October.
22. shillington m, adam cJ, labrom rd, askin gn. The biomechanical effects of thoracic spine stapling. 15th International Meeting on Advanced Spine Techniques (IMAST). hong kong, 8–11 July 2008.
23. steck r, gregory l, minehara h, wullschleger m, schuetz m. Three dimensional visualisation of callus geometry in new murine fracture model. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.
[ 1 4 ] p u b l i C a t i o n s
24. sugiyama s, goss B, wullschleger m, wilson k, williams r. Reliability of clinical measurement for assessing spinal fusion: an experimental sheep study. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.
25. wullschleger m, schmutz B, ito k, steck r, schuetz m. Minimally invasive versus open plate osteosynthesis: Quantitative radiographic analysis of callus morphology of distal femur fractures in sheep using computed tomography imaging. 14th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society. Brisbane, australia. 17–18 november 2008.
26. wullschleger m, schmutz B, ito k, steck r, schuetz m. Minimally invasive plate osteosynthesis: Quantitative analysis of callus formation in a distal femur fracture model in sheep using computed tomography imaging. 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). hobart, australia. 12–15 October 2008.
27. wullschleger m, neilsen s, nijboer a, mcnamee a, lefering r, schuetz m. secondary referred trauma patients: comparison to those with primary admissions to a tertiary hospital in south-East Queensland. Swan XVI Conference, Liverpool Hospital. sydney, australia. 25–26 July 2008.
28. wullschleger m, steck r, wilson k, ito k, schuetz m. Minimally invasive plate osteosynthesis: Advanced early fracture healing in an ovine trauma model. 68th Annual Scientific Meeting of the Australian Orthopaedic Association (AOA). hobart, australia. 12–15 October 2008.
gUEsT PREsENTATiONs
Orthopaedics and Trauma Queensland
wishes to thank our visiting guest
presenters for 2008:
› Professor saso ivanovski, chair of Periodontology at griffith university.
› dr hans de visser, australian e-health research centre, csirO
› dr andrew ward, intellidesign. › anne Trimmer, chief executive Officer,
medical Technology association of australia.
› associate Professor nigel morrison, school of medical sciences, griffith university
› dr mark gillies, worley Parsons › Professor stephan Perren and
nicholas Perren
s t a f f [ 1 5 ]
NAME TiTLE
AO BRisBANE sPiNE gROUP
dr richard williams centre director
dr Ben goss research Fellow
dr sadahiro sugiyama research Fellow
dr con vasili clinical Fellow
dr alexander gibson clinical Fellow
ms sanela stanojevic research assistant
ms rachel luton-goggins administration coordinator
MEdicAL ENgiNEERiNg
Professor mark Pearcy Professor of Biomedical engineering medical device domain leadermedical engineering Theme leader
Professor John evans adjunct Professor
associate Professor xigeng (simon) miao associate Professor
dr sanjay mishra senior lecturer
ms deborah whiting research Theme coordinator
mr keith Officer merF Operations manager
ms carmel Johnson merF administrative Officer
mr James kelly anatomical skills laboratory manager, merF
mr greg Tevelen supervising Technician/dry laboratory manager
dr kathleen wilson Biological research Facility manager, merF
mr david mcintosh Technician, merF
mr ian mellor cadaveric assistant, merF
mr michael lindeberg Biological research Facility attendant, merF
mr Peter lindeberg Biological research Facility attendant, merF
mr Bill sommers Biological research Facility attendant, merF
mr kimble dunster research associate
ms shobha mareddy research assistant
dr mark davies visiting Fellow
dr John Fraser visiting Fellow
dr andreas schibler visiting Fellow
NORThsidE sPiNAL REsEARch gROUP
dr Paul licina spinal Orthopaedic surgeon
ms carmen sutton research assistant
ORThOPAEdic REsEARch gROUP
Professor ross crawford chair in Orthopaedic research
Professor kunle Oloyede leader, cartilage Biomechanics group
associate Professor Yin xiao leader, Bone Biology group
dr cameron lutton Postdoctoral research Fellow
dr Yufeng Zhang Postdoctoral Fellow
dr lance wilson research Fellow
dr sarah whitehouse research Fellow
dr ngiem doan visiting Fellow
dr Tim Barker visiting Fellow
staff
[ 1 6 ] s t a f f
dr Ying Zheng visiting Fellow
dr corey richards visiting Fellow
dr Juju (chewy) Joseph visiting Fellow
ms louise hood clinical data manager
ms sue grice clinical research nurse
mr Thor Friis research assistant
ms wei shi research assistant
mr cameron Brown research assistant
mr darcy hinde research assistant
ms Jane wiseman Personal assistant
PAEdiATRic sPiNE REsEARch gROUP
dr geoff askin spinal Orthopaedic surgeon
associate Professor clayton adam Principal research Fellow
dr James cordell-smith clinical Fellow
dr robert labrom spinal Orthopaedic surgeon
dr Paige little Postdoctoral research Fellow
dr matthew shaw clinical Fellow
dr mark shillington clinical researcher
mrs maree izatt senior research assistant
REgENERATivE MEdiciNE gROUP
Professor dietmar hutmacher chair in regenerative medicine
dr Travis klein Postdoctoral research Fellow
dr maria woodruff Postdoctoral research Fellow
dr Johannes reichert research Fellow
dr siamak saifzadeh research Fellow
dr Paul dalton research Fellow
ms verena Quent research assistant
ms victoria Taverner Personal assistant
TRAUMA REsEARch gROUP
Professor michael schuetz chair in Trauma
Professor lutz claes adjunct Professor
Professor norbert haas adjunct Professor
Professor stephan Perren adjunct Professor
dr roland steck senior research Fellow
dr devakara epari senior research Fellow
dr Beat schmutz senior research Fellow
dr gongfa chen Post doctoral research Fellow
dr herwig drobetz visiting research Fellow
dr david mcmillan visiting research Fellow
ms salma ibrahim research assistant
ms caroline grant research assistant
ms natalie rosenzweig research assistant
mrs rebecca Bibby executive support Officer
mrs caryll clifford executive support Officer
a d j u n C t p R o f e s s o R i a l s t a f f [ 1 7 ]
› dr geOFFreY askin
› PrOFessOr luTZ claes
› dr Bill dOnnellY
› dr JOhn earwaker
› PrOFessOr JOhn evans
› PrOFessOr nOrBerT haas
› dr Paul licina
› PrOFessOr sTePhan Perren
› dr richard williams
Finite element simulations: (top) of a rat ulna compression model, which is used for studying stress fracture healing; (bottom) to predict correctly the location of the stress fracture.
adjunct professorial staff
[ 1 8 ] H i g H e R d e g R e e R e s e a R C H s t u d e n t s
Higher degree research students
NEw sTUdENTs
doctor of Philosophy
NAME dETAiLs
krishnakanth, Pushpanjali characterisation of fracture stabilization device variables by analytical and finite element models
kuaha, kunikka characterization of adult mesenchymal stem cells derived from perivascular umbilical cord and investigating the potential use for regeneration of cartilage
Quent, verena application of a human bone engineering platform to an in vitro and in vivo prostate and breast cancer model
grant, caroline understanding the biomechanical effects of fixation strategies to improve the technology of fracture management
Toal, victoria The mechanics of microdamage and microfracture in trabecular bone
rathnayaka, kanchana magnetic resonance imaging (mri) of long bones
chun, Ju Ok (June) engineering articular cartilage with zonal structure and function
irawan, daisy Functionalised gellan gum for cartilage regeneration
sin, dong choon (daniel) Porous coating on titanium substrate for the growth of an endothelial layer
clemens, stephan a reference process model for multi-trauma patients
Master of Engineering
NAME dETAiLs
roe, John geometry and stability of tapered femoral stems in bone cement
ibrahim, salma application of optimisation methods for improving screw configurations in bone fracture plate fixation
Thomas, dr chris determinants of internal fixation stability and fracture healing
cONTiNUiNg sTUdENTs
doctor of Philosophy
NAME dETAiLs
kaur, navdeep identification and characterization of the molecular signatures of the mesenchymal stem cell
afara, isaac development of the smarthroscope for surgical assessment and treatment decisions
lai, chun-chih Frank aFm study of mesenchymal stem cells on biomaterials
reichert, dr Johannes reconstruction of critical sized segmented bone defects in a large animal model
shiu, hoi Ting Prothrombogenic bone grafts
Prasadam, indira Osteoblast and chondrocyte interactions in osteoarthritis
Yusuf, kehinde modelling of transport process in normal and degenerate articular cartilage with specific reference to the action of phospholipid surfactants
cunningham, helen an experimental and finite element investigation of the biomechanical outcomes of scoliosis correction surgery.
duong, Quang Thien development of a structural model of articular cartilage: an experimental and visualisation study
Fan, wei Periosteum tissue engineering and its in vivo application in bone defect healing
wullschleger, martin effect of surgical approach on bone vascularisation, fracture and soft tissue healing: comparison of less invasive and open surgical approach
mcdonald, katrina an experimental and finite element investigation of the biomechanical outcomes of vertebral compression fracture
watts, mark charles Forces at the tendon bone interface in reconstructive surgery
H i g H e R d e g R e e R e s e a R C H s t u d e n t s [ 1 9 ]
cairns, nicola The feasibility of vibration analysis as a technique to detect osseointegration of transfemoral implants
Young, Yun wai (will) secondary therapies for spinal cord regeneration
sieh, shirly development of a three dimensional culture system to study the skeletal metastasis of Prostate cancer (caP)
liu, gang The guided differentiation of bone marrow mesenchymal stem cells into bone-cartilage neotissue for osteochondral tissue engineering
Master of Engineering
NAME dETAiLs
Beldiman, monica assessment of the effectiveness and safety of lipid-based joint remedial formulation in-vitro
couzens, gregory a testing rig to measure forces across the cadaver wrist under physiological loading
shillington, mark Biomechanics of shape memory alloy staples for fusionless correction of scoliosis
sattar, imran development of a portable 3d profiling device for cim of customised medical seats
cOMPLETiONs
doctor of Philosophy
NAME dETAiLs
mareddy, shobha single cell derived clones of bone marrow stromal cells from osteoarthritis patients: molecular and cellular characterisation
Brown, cameron development and synthesis of innovative approaches to the surgical assessment of articular cartilage degeneration
sanjleena singh separation and characterization of multipotent cells from osteophytes in osteoarthritis.
gale, lorne Biotribological assessment of artificial synovial joints: the role of boundary lubrication
cargill, sara clare Biomechanical modelling of the lumbopelvic musculoskeletal system in sitting and standing
Master of Engineering
NAME dETAiLs
mayo, andrew an experimental investigation of the mechanics of vertebral body screws used in spinal deformity surgery
OvERsEAs visiTiNg sTUdENTs
NAME UNivERsiTy
ingrid knippels radboud university, The netherlands
armand Tillie radboud university, The netherlands
lianne de kleijn radboud university, The netherlands
lu liu sun Yat-sen university, china
wei Fang wuhan university, china
Bart rijckaerts Twente university, The netherlands
saskia wilting radboud university, The netherlands
anne van eijk radboud university, The netherlands
eleonora carletti university of Trento, italy
claudia schaar FhTw university of applied sciences
mark stamer Technical university hamburg-harburg, germany
klaus michael uhr Technical university hamburg-harburg, germany
[ 2 0 ] a w a R d s , p R i z e s a n d C o m m u n i t y s e R v i C e
awards, prizes and community service
› mark Pearcy was presented with the international conference on Biomedical engineering (icBme) honorary distinguished award at this year’s 13th icBme. This award was to recognise his distinguished contributions in the field of biomedical engineering and in particular for his continued strong support of the icBme series of conferences over the years
› Ben goss, cameron lutton and will Young from QuT, together with alan mackay-sim and adrian meedeniya from griffith university were awarded the spine society of australia (ssa) research award for 2008 at the annual scientific meeting of the ssa in adelaide in april 2008, for their paper: ‘reduction of secondary degeneration after spinal cord injury by acute delivery of vascular growth factors’.
This is a prestigious award and is awarded following submission of a full, journal length paper, before the ssa’s annual scientific meeting. The papers are reviewed by the three members of the scientific committee prior to the meeting. This year there were 11 papers submitted all of which were deemed to be of a high standard. The award recognised that the paper was an excellent presentation of innovative, exciting and well conducted research. Ben also presented a well received account of the research at the meeting which prompted considerable discussion.
› dr Ben goss was runner up in the Queensland Premier’s awards for health and medical research – senior researcher award
› victoria Toal (Phd student) commenced her studies in march 2008 on ‘The mechanics of microdamage and microfracture in trabecular bone’. her outstanding academic performance ensured she received a prestigious smart state Phd scholarship. victoria was also selected to attend the ‘Brightest Young minds’ summit in sydney in July and was a finalist in the ‘smart women’s, smart state awards’, held in september. her work aims to increase understanding of how damage occurs in our bones at the microstructural level under different loading conditions. such damage is present in all bones, but is of greater concern for those who have weaker bones due to disorders such as osteoporosis. victoria aims to achieve her goals using experimental methods as well as computer modelling.
› ingrid knippels, a visiting student from radboud university in nijmegen, The netherlands, and roland steck were awarded the ‘Best basic science poster’ award at the meeting of the int. society for Fracture repair in south lake Tahoe, nv (13–16 July 2008) for the paper by i knippels, l kidd and m Forwood (both university of Queensland), m schuetz, and r steck on: ‘characterisation of the rat ulna compression model using microcT and Finite element calculations’.
› Prof michael schuetz was invited as the racs Foundation visitor to the annual australian Orthopaedic meeting in hobart/October 2008.
› acknOwledgemenTs
Orthopaedics and Trauma Queensland gratefully
acknowledges the significant financial and
collaborative support of:
› aO Foundation
› australian research council
› dePuy spine
› golden casket research Foundation
› holy spirit northside hospital
› institute of health and Biomedical innovation
› mater Foundation
› mater health services Brisbane ltd
› medtronic sofamor danek
› national health and medical research council
› Princess alexandra hospital
› Queensland health
› Queensland Orthopaedic research Trust
› Queensland university of Technology
› Queensland x-ray
› royal australasian college of surgeons
› synthes
› stryker
› The Prince charles hospital
› The Prince charles hospital Foundation
› The wesley research institute
© QuT 2009 Produced by QuT Publications 16039 cricOs no. 00213J