Orunmila Pharma, Inc

First in class HIV-1 derived small peptides that target HSP-70 family member Mortalin and DnaK as therapeutic for cancer, viral replication, inflammation and bacterial infection with little

to no toxicity .

Vincent C. Bond, PhD; CEO and PresidentMing Bo Huang, MD; CRO

Technology: • Mortalin/HSPA9 and DnaK (HSP70) antagonists for the treatment of cancer, inflammation, and

infections.

Issued Patents: • US 8,431,530; US 8,476,237; US 8,551,943; US 8,563,506; US 8,669,226; EP 2440570,

DE602010009528.2.

Patent Applications:• US 13/267,977; US 13/327,244; CA 2,761,121; JP 2012-514976; CN 201080025184.7; HK

12108236.3; IN 8365/CHENP/2011; PCT US2011/055219, and PCT/US11/065137.

Applications:• A dominant and expanding patent position for the composition and use of SMR (& derivatives).• Treatment of cancer, viral infected, and inflammatory cells that over-express mortalin.• Treatment of antibiotic resident bacteria that express DnaK.

Value Proposition:• Demonstrated efficacy i) mortalin-SMR binding; ii) reduction in exosome secretion; iii) induction of

cancer cell, but not “normal” cell death, iv) reduction in HIV particle secretion; and v) bacterial growth inhibition.

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250x103

500x103

750x103

3x106

5x106

8x106

1e+5

1e+6

1e+7

SMRwt peptide in Jurkat SMRmt peptide in Jurkat

SMRwt has no toxic effect on target cellsgrowth.

SummaryNef (Negative Regulatory Factor) is a protein expressed by primate lentiviruses

and a virulence factor able to manipulate host cell machinery. Regions interact with multiple host factors including CXCR4. We identified the SMR as a virus-ended secretion modification region that inhibits an intracellular target HSP 70 family member called mortalin (HSPA9, glucose-regulated protein 75 [GRP75], and peptide-binding protein protein 74 [PBP74]). Mortalin plays an important role in cell proliferation. The SMR peptide, developed by our group, binds with pM affinity to mortalin, and nM affinity to bacteria DnaK acting as an antagonist. It has little toxic effect on target cells. MSM was the first to demonstrate efficacy of HIV-1 derived peptides as therapeutics for cancer, viral replication, inflammation and bacterial infection.

SMRwtSMRmut