FREEDOM TO ROAM

Osteoarthritis & pain management

Weight Control.

Complementary Analgesics.

Moderate exercise.

Physiotherapy and Rehabilitation.

NSAIDs (Nonsteroidal anti-inflammatory drugs).

Nutritional supplement-Chondroprotectors

Chondroitin sulfate and Hyaluronic acid supplement.

20% dogs over 1 year of age are affected.

Cats are less affected or joint disease often goes unrecognized.

It cursed with chronic pain:

Crying out, yelping, sensitivity to palpation and favoring a limb.

Excitement and nervousness.

Lameness.

Limping or unusual gait.

Loss of tolerance to exercise and reluctance to play.

Decrease of progressive ROM (mobility range) and fibrosis.

Crepitus in affected joints.

Joint noise such as popping and cracking.

OSTEOARTHRITIS DISEASE

OSTEOARTHRITIS & PAIN MANAGEMENT

PREVENTION AND TREATMENT

Osteoarthritis disease (OA) is a degenerative joint disease, that affects bones, ligaments and joints.

It is common in aging animals and excessive body weight (obesity) can exacerbate the disease.

Large and giant breed dogs are genetically predisposed (e.g. Golden Retrievers, Labrador Retrievers, German Shepherds, Great Danes, Newfoundlands).

The main symptoms are pain and stiffness, affecting the quality of life.

The clinical signs are varied:

Common disease which requires a multimodal management

Normal joint Affected joint

OSTEOARTHRITIS & PAIN MANAGEMENTANIMAL WELFARE

OBJECTIVE: Minimize patient discomfort and improve quality of life.

What’s animal welfare?Animal welfare means how an animal is dealing with the conditions in which it lives. The standards of “good” animal welfare are established by OIE-WOAH, 2011:

Correct working of the organism (healthy and good feeding).

Emotional status of the animal.

Express some normal conducts of the specie.

Pain managementAppropriate pain management requires a continuum of care based on a well-thought-out plan that includes: anticipation, early intervention and evaluation of response on an individual-patient basis.

The relief of animal pain and suffering is the key to successful case outcomes and enhancement of the veterinarian-client-patient relationship. In conclusion, a good quality of life.

HYALUTIDIN® DC

HYALUTIDIN® DC is a feed supplement, chondroprotector, that is composed by a high quality hyaluronic acid and chondroitin sulfate combination (HCC: HC-Complex).

The most important innovation of the product is its liquid form and a specific chemical chain, which introduces both substances at the same time as the complex, which ensures absorption into the body at the level of almost 100%.

HYALUTIDIN® DC has an easy administration because it is sweet and well tolerated, also for cats.

The difference between the rest of chondroprotectors is that the synthesis of hyaluronic acid is 100% animal-free. It is synthesized by natural procedures through the cultivation of bacteria. Hyaluronic acid produces that synovial fluid viscosity increase, reduce inflammation and suppress the formation of inflammatory mediators.

HYALUTIDIN® DC is used for the lubrication of joints and cartilage recovery. Also, for animals with joint problems or after surgery, older dogs and cats, athletic and working dogs, and growing animals. It is suitable for each stage of life.

Composition: Hyaluronic acid, Chondroitin

sulfate (HCC). 25mg/mL HCC

Fructose, Glucose syrup. Vitamin E. Potassium sorbate. Saccharose.

HC-ComplexC

O M P L E

XHyaluronic acid is hypoallergenic 100% animal free

HYALUTIDIN® DC is an extraordinary quality product for a faster and better Osteoarthritis relief and joint regeneration in OA 0-4 scale.

It has an oral application in two formats: 1x 125 ml, 2 x 125ml. No side effects.

With HYALUTIDIN® DC recover fast movements again.

*Based on clinical multicentric non-randomized study with 30 dogs with arthrosis for 30 days.

Dosage cats Body weight Unit/Day

Small cats < 5 kg 1 ml/day

Medium cats 5–10 kg 2 ml/day

Large cats > 10 kg 3 ml/day

Dosage dogs Body weight Unit/Day

Small dogs < 10 kg 2 ml/day

Medium dogs 10–30 kg 4 ml/day

Large dogs 30–50 kg 6 ml/day

XXL dogs > 50 kg 8 ml/day

LÖHLEIN & WOLF

Assessment by Veterinarians

25

20

15

10

5

0

Number of dogs according to lameness score Number of dogs according to lameness score

100%

80

60

40

20

0

Day 0

Mild OA Moderate OA Sever OA

Day 15 Day 30 Improved Same None

Day 15 Day 30

72,4% of dogs improved after HYALUTIDIN® DC use

Impro

vement by

HC-COMPLEX introduces exogenous hyaluronic acid and stimulates the production of endogen hyaluronic acids, resulting increase intrarticular viscosity and an extraordinary ability to remodel and repair the cartilage. In addition, chondroitin is needed as a building block for the cartilage.

Assessment by owners

25

20

15

10

5

0

Number of dogs according to lameness score Number of dogs according to lameness score

100%

80

60

40

20

0

Day 0

Mild OA Moderate OA Sever OA

Day 15 Day 30 Improved Same None

Day 15 Day 30

93,1% of dogs improved after HYALUTIDIN® DC use

Impro

vement by

Hyaluronic acid

Chondroitin sulfate HC-Complex}

Liquid form and sweet.

Well-tolerated.

Results in 2-3 weeks

Lubrication of joints and cartilage recovery.

Hyaluronic acid is hypoallergenic -synthesized 100% animal free.

Suitable for each stage of life and OA scale.

DOLOCARP FLAVOURCarprofen chewable tablets

DOLOCARP FLAVOUR has Carprofen as active ingredient.

Selective inhibitor for COX-2.

Chewable tablet for oral use with a score line.

Only use for dogs.

High palatability with liver flavour.

White bottle made of polyethylene with childproof seal.

Envelopes dispenser.

Indications

Reduction of inflammation and pain caused by acute and chronic musculoskeletal disorders.

Management of post-operative pain in dogs.

Dosage

4mg/kg/ 24h and in cases of long treatment 2mg/kg/ 24h.

The treatment period depends on the clinical development of the disease.

DOLOCARP FLAVOUR vs Originator carprofen productStudy design:

51 dogs (ages 3-17 years, 5-54 kg).

Different breeds.

Domestic environment.

EXCELLENTPALATABILITY –TESTED IN DIFFERENT BREEDS100%comparable to the originator carprofen product

DOLOCARP FLAVOUR PALATABILITY STUDYA variety of dog breeds undergone a controlled palatability study, in which DOLOCARP FLAVOUR chewable tablets and Originator carprofen

product were given to the participating dogs in their home environment.

Independently of the breed DOLOCARP FLAVOUR was ingested

without any problems by 96 % of the dogs either from the bowl, from the owners hand or with a small amount of food.

Presentations

Pack sizes: 20 and 100 tablets.

DOLOCARP FLAVOUR 20 mg.

DOLOCARP FLAVOUR 50 m.

DOLOCARP FLAVOUR 100 mg.

Same palatability as the Originator carprofen

DOLOCARP FLAVOUR

chewable tablets96%

Originator

carprofen product96%

ANIMELOXANMeloxicam oral suspension and solution for injection

ANIMELOXAN has Meloxicam as principle ingredient.

Preferentially inhibiting COX-2 over COX-1.

Control OA pain and many other painful conditions.

Dosing syringe for oral suspension.

To be administered mixed with food.

A clinical response is normally seen within 3 - 4 days.

Dogs: Alleviation of inflammation and pain in both acute and chronic musculoskeletal disorders. Reduction of post-operative pain and inflammation following orthopaedic and soft tissue surgery.

Cats: Reduction of post-operative pain after ovariohysterectomy and minor soft tissue surgery.

Dosage: 0.2 mg/kg/ 24h for the first day and then 0.1 mg/kg/24h.Particular care should be taken with regard to the accuracy of dosing.

NORMAL OSTEOARTHRITISOSTEOARTHRITIS

ADVANCED OSTEOARTHRITISADVANCED

STAGES OF OSTEOARTHRITIS (Degenerative joint disease)

Presentations

ANIMELOXAN 1,5 mg/ml oral suspension for dogs. It has 3 formats: 10ml, 32 ml, 100ml.

ANIMELOXAN 5 mg/ml injection suspension for dogs and cats

Bone

Cartilage

Joint Capsule

Irregular joint spaceFragmented cartilageLoss of cartilageSclerotic boneCystic

Bone Cysts

Sclerotic Bone

Cartilage fragments

OsteophytesPeriarticular fibrosisCalcified cartilage

Osteophytes

Calcifiedcartilage

Periarticularfibrosis

DOLOCARP FLAVOUR PALATABILITY STUDY

NSAIDs

HYALUTIDIN®DC

HYALUTIDIN® DC. Hyaluronic acid and Chondroitin Complex (25.000 mg/l) 125 ml. Species. Dogs and cats. Indications. Leads to an improvement of the cartilage function and even to a complete regeneration of the cartilage. It is recommended for older dogs and cats, joint diseases, after joint surgery, growing animals, working dogs and animals with genetic predisposition. Contraindications. Does not have significant side effects. Amounts to be administered. For oral administration in dogs: small dogs (up to 10kg) 2ml/day, medium dogs (10-30 kg) 4ml /day, large dogs (30-50 kg) 6 ml/day, XXL dogs (>50kg) 8 ml/day. For oral administration in cats: small cats (up to 5kg) 1ml/day, medium large cats (5-10 kg): 2ml/day, large cats (>10kg) 3ml/day. Hyalutidin® DC is recommended to be given for 30 consecutive days. Shelf life. 3 years. Storage. store in cool and dry place, protected from light.

DOLOCARP FLAVOUR tablets. Carprofen 20 mg, 50 mg and 100mg. Species. Dogs. Indications. Reduction of inflammation and pain caused by acute and chronic musculoskeletal disorders (e.g. osteoarthritis). As a follow up to parenteral analgesia in the management of post-operative pain. Contraindications. Should not be use: in cats, in pregnant or lactating bitches and in animals suffering from cardiac, hepatic or renal disease, where there is a possibility of gastrointestinal ulceration or bleeding or where there is evidence of a blood dyscrasia. Do not use in cases of hypersensitivity to the active substance, to other NSAIDs and to any of the excipients. Amounts to be administered. for oral administration. Recommended dose rate 4mg/kg/d in single daily administration. Shelf life. 4 years. Shelf life of tablet halves. 2 days. Storage. does not require any special temperature storage conditions, store in a dry place. Keep the bottle tightly closed. Marketing authorisation holder: AniMedica GmbH, Im Südfeld 9. 48308 Senden-Bösensell. Germany.

ANIMELOXAN solution for injection. Meloxicam 5 mg/ml. Species. Dogs and cats. Indications. Dogs: Alleviation of inflammation and pain in both acute and chronic musculo-skeletal disorders. Reduction of post-operative pain and inflammation following orthopaedic and soft tissue surgery. Cats: Reduction of post-operative pain after ovariohysterectomy and minor soft tissue surgery. Contraindications. Should not be use in animals less than 6 weeks of age nor in cats of less than 2 kg, neither in case of hypersensitivity to the active substance or to any of the excipients. Do not use in animals suffering from gastrointestinal disorders such as irritation and haemorrhage, impaired hepatic, cardiac or renal function and haemorrhagic disorders. Amounts to be administered. For subcutaneous injection. Recommended dose rate 0.2 mg/kg/d in single daily administration. Particular care should be taken with regard to the accuracy of dosing. Shelf life. 2 years. Shelf life after first opening the immediate packaging. 28 days. Storage. does not require any special temperature storage conditions. Marketing authorisation holder: AniMedica GmbH, Im Südfeld 9. 48308 Senden-Bösensell. Germany. ANIMELOXAN oral suspension. Meloxicam 1,5mg/ml. Species. Dogs. Indications. Alleviation of inflammation and pain in both acute and chronic musculo-skeletal disorders. Contraindications. Should not be use in pregnant or lactating animals and dogs less than 6 weeks of age. Do not use in animals suffering from gastrointestinal disorders such as irritation and haemorrhage, impaired hepatic, cardiac or renal function and haemorrhagic disorders, neither use in case of hypersensitivity to the active substance or to any of the excipients. Amounts to be administered. Initial treatment is a single dose of 0.2 mg meloxicam/kg body weight on the first day. The treatment is to be continued once daily by oral administration (at 24-hour intervals) at a maintenance dose of 0.1  mg  meloxicam/kg body weight. Particular care should be taken with regard to the accuracy of dosing. Shelf life. 3 years. Shelf life after first opening the immediate packaging. 6 months. Storage. does not require any special temperature storage conditions. Marketing authorisation holder: AniMedica GmbH, Im Südfeld 9. 48308 Senden-Bösensell. Germany.

HYALUTIDIN® DC DOLOCARP FLAVOUR ANIMELOXANHC-Complex Meloxicam oral suspension

and solution for injection

LIVISTO Int´l S.L.Avda Universitat Autònoma, 29.Cerdanyola del Vallès. (Barcelona) Spain.

Carprofen chewable tablets for dog