our microbial organsitn.hms.harvard.edu/wp-content/uploads/2010/09/microbe1.pdf · our microbial...
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Our Microbial OrganThe Good and Bad Bugs of the Human Gut
Kevin BonhamNadia CohenKyle Perry
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Outline for the Evening
• Kevin Bonham – Living in a MicrobialWorld
• Nadia Cohen – The Gut and itsInhabitants
• Kyle Perry – Microbial Populations: Howwe study them and how we use them
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• Bacteria in the News
• What are bacteria?
• The “Microbiome”
• Where do they come from?
Living in a Microbial World
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Bacteria in the News
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Everything’s “Contaminated”
Are 3D-Glasses Sanitary?
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• Bacteria in the News
• What are bacteria?
• The “Microbiome”
• Where do they come from?
• Brief Interlude on Bacteria and the
Immune system
Living in a Microbial World
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Cells Are the Basic Unit of Life
http://commons.wikimedia.org/wiki/File:Average_prokaryote_cell-_en.svg
http://scienceblogs.com/clock/2006/11/cell_structure.php
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90% Microbe
~ 10 Trillion Human Cells
~ 100 Trillion Bacterial Cells
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Cells Are the Basic Unit of Life
http://commons.wikimedia.org/wiki/File:Average_prokaryote_cell-_en.svg
http://scienceblogs.com/clock/2006/11/cell_structure.php
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Cells Are the Basic Unit of Life
http://commons.wikimedia.org/wiki/File:Average_prokaryote_cell-_en.svg
http://scienceblogs.com/clock/2006/11/cell_structure.php
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Commensal: An organismthat colonizes you but doesno harm
Pathogen: An organism thatcauses disease
The Good vs the Bad
http://phil.cdc.gov (10041, 10076, 10987)
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• Bacteria in the News
• What are bacteria?
• The “Microbiome”
• Where do they come from?
• Brief Interlude on Bacteria and the
Immune system
Living in a Microbial World
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Different Environments haveDifferent Bacteria
Elizabeth K. Costello et. al. (December 2009) Science 326 (5960), 1694. [DOI: 10.1126/science.1177486]
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Different Environments haveDifferent Bacteria
Elizabeth K. Costello et. al. (December 2009) Science 326 (5960), 1694. [DOI: 10.1126/science.1177486]
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Different Environments haveDifferent Bacteria
Elizabeth K. Costello et. al. (December 2009) Science 326 (5960), 1694. [DOI: 10.1126/science.1177486]
![Page 16: Our Microbial Organsitn.hms.harvard.edu/wp-content/uploads/2010/09/Microbe1.pdf · Our Microbial Organ The Good and Bad Bugs of the Human Gut Kevin Bonham Nadia Cohen Kyle Perry](https://reader035.vdocument.in/reader035/viewer/2022070721/5ee33bb4ad6a402d666d3ca8/html5/thumbnails/16.jpg)
• Bacteria in the News
• What are bacteria?
• The “Microbiome”
• Where do they come from?
• Brief Interlude on Bacteria and the
Immune system
Microbes Galore
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Colonized from birth
Natural birth Caesarian Section
Mother:Birth canal
Baby:Skin
Mother:Skin
Baby:Skin
Maria G. Dominguez-Bello et. al. (Jun, 2010) PNAS [DOI: 10.1073/pnas.1002601107 ]
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Next up!
• Kevin Bonham – Living in a Microbial World
• Nadia Cohen – The Gut and its Inhabitants
• Kyle Perry – The Future of MicrobialScience
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Thank you!
Questions?
Shameless plug:
scienceblogs.com/webeasties