Our Solution

Use antifouling polymer coating

Recesses

Leaflets

Patent Search• Novelty of the design • FDA requirements

Patent Search

Mechanical Valve

Polymer

Coating Mechanism

Prosthetic Heart Valve with Surface Modification

Patent No. : US6764509 Issue date Jul 20, 2004

• Owned by Medtronic • Coating with a chemical substance to prevent:

Thrombus formation

Mineralization

Does not include zwitterionic carboxy betaine or its derivatives (CB-OH)

Plasma Process Surface Modification onto Pyrolytic Carbon

Patent Number: 637228Issue Date: Apr 16, 2002

• Owned by Medtronic Inc

• Purpose: Adhesion of the polymer and/or bioactive compound on pyrolytic carbon

• Plasma deposition of a silicon and oxygen film

HridhayCoeur Patent 1. A mechanical heart valve comprising titanium body, pyrolytic carbon flaps and Dacron sewing

cuff, with modifications that make it have negligible immuno-rejection by the body.2. The heart valve of claim 1, wherein the valve is a bi-leaflet mechanical heart valve.3. The heart valve of claim 1, wherein the pyrolytic carbon component is modified by coating with

anti-fouling polymers.4. The heart valve of claim 3, wherein said modification method is done prior to implantation and

reduces the risk of hemolysis, infection and/or thrombogenesis to the implant.5. The heart valve of claim 3, wherein anti-fouling polymer is deposited via the plasma deposition

process.6. The heart valve of claim 3, wherein the polymer used is zwitterionic carboxy betaine (CB-OH).7. The polymer of claim 6, wherein CB-OH and/or any other modification or derivations of CB-OH

are used to achieve same or similar properties.8. The polymer of claim 7, wherein the polymer is added to and/or coating is done on any type of

implant.9. The polymer of claim 7, wherein the polymer is added to and/or coating is done partially on any

type of implant.10. The polymer of claim 7, wherein the polymer is added to and/or coating is done on any type of

valve.11. The polymer of claim 7, wherein the polymer is added to and/or coating is done partially on any

type of valve.

HridhayCoeur Patent

“The coating of mechanical heart valve with zwitterionic carboxy betaine (CB-OH) or its derivatives to increase antithrombotic or antimicrobial properites and hence minmize immuno-rejection by the body.”

Medtronic

• Competitive Market Need for differentiation

• Minimize non-specific protein adsorption • Improve blood compatibility

We have the answer!

Medtronic Open Pivot Mechanical Heart Valve

Benefits

To Medtronic• Novel Technology• Market leadership• Wider pool of knowledge and skills • Business contact

To HirdayCoeur• Capital• Reputation