overview : innate immune response
DESCRIPTION
Overview : Innate Immune Response. Inflammation. Recruitment from the bloodstream. Inflammation. Phagocytosis of a bacterium. Inflammation. Inflammation. Soluble Molecules. • Proinflammatory cytokines: •IL-1 • TNF a •Antimicrobial peptides - PowerPoint PPT PresentationTRANSCRIPT
Overview:
InnateImmune Response
InflammationRecruitment from the bloodstream
InflammationPhagocytosis of a bacterium
Inflammation
Inflammation
Soluble Molecules•Proinflammatory cytokines:
•IL-1•TNFa
•Antimicrobial peptides
•Acute phase response (APR) and acute phase response proteins•complement proteins•C-reactive protein (CRP)•Mannose-binding lectin (MBL)
Receptors Detect Infection
Receptors Detect Infection•Classification of PRRs:
a) signaling b) endocytic•Membrane bound:
Toll-like receptors (TLR)C-type lectin receptor (CLR)Scavenger receptors (SRs)Lipopolysaccharide receptor (LPR)
•Cytoplasmic:NOD-like receptors (NLR)
•Secreted:Mannose-binding lectin (MBL)Complement receptorsC-reactive protein (CRP)LPS-binding protein (LBP)
Receptors Detect Infection
Toll-like Receptors
Toll-like Receptors
Cells involved in innate immunity•Neutrophils
•Macrophages
•Dendritic cells
•Natural killer cells
Signal Transduction
Signal Transduction
Signal Transduction
Signal Transduction
Signal Transduction
Ubiquity of Innate Immunity