p09: non-neoplastic lesions by individual … rats/f 344/n lab: mba day on test 0 0 5 7 0 0 5 7 0 0...
TRANSCRIPT
![Page 1: P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL … RATS/F 344/N Lab: MBA DAY ON TEST 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5 7 0 0 5](https://reader031.vdocument.in/reader031/viewer/2022022520/5b18def07f8b9a1e258c3173/html5/thumbnails/1.jpg)
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
F1_R2_9Wk_SSAC
C Number: C20537
Lock Date: 11/19/2007
Cage Range: ALL
Date Range: ALL
Reasons For Removal: 25017 SSAC
Removal Date Range: ALL
Treatment Groups: Include 004 VEHCONTRCOHRTD Include 009 2-8ADHAQP1COHTD Include 014 8-9ADHAQP1COHTD
Include 019 2-11ADHAQP1COHTD
Study Gender: Male
TDMSE Version: 2.1.0
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ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + 5.........................................................................................................................................................................................................
Liver + + + + + 5Inflammation 1 1 2 1.0
.........................................................................................................................................................................................................
Oral Mucosa + + + + + 5.........................................................................................................................................................................................................
Pancreas + + + + + 5.........................................................................................................................................................................................................
Salivary Glands + + + 3Right, Submandibular Gland, Regeneration 1 2 1 3 1.3
.........................................................................................................................................................................................................
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
VEHCONTRCOHRTD
00016
00017
00018
00019
00020 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 2
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Stomach, Forestomach + + + + + 5.........................................................................................................................................................................................................
Stomach, Glandular + + + + + 5.........................................................................................................................................................................................................
Tongue + + + + + 5
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Blood Vessel + + + + + 5.........................................................................................................................................................................................................
Heart + + + + + 5Cardiomyopathy 1 1 1.0
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + 5.........................................................................................................................................................................................................
Adrenal Medulla + + + + + 5.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + 5.........................................................................................................................................................................................................
Parathyroid Gland + + + + + 5.........................................................................................................................................................................................................
Pituitary Gland + + + + + 5.........................................................................................................................................................................................................
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
VEHCONTRCOHRTD
00016
00017
00018
00019
00020 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 3
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Thyroid Gland + + + + + 5
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + 5.........................................................................................................................................................................................................
Preputial Gland + + I + + 4.........................................................................................................................................................................................................
Prostate + + + + + 5.........................................................................................................................................................................................................
Seminal Vesicle + + + + + 5.........................................................................................................................................................................................................
Testes + + + + + 5
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + 5.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M 0.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + 5.........................................................................................................................................................................................................
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
VEHCONTRCOHRTD
00016
00017
00018
00019
00020 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 4
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Spleen + + + + + 5.........................................................................................................................................................................................................
Thymus + + + + + 5
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland + I + M M 2.........................................................................................................................................................................................................
Skin + + + + + 5
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + 5
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + 5
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + 5.........................................................................................................................................................................................................
Nose + + + + + 5.........................................................................................................................................................................................................
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
VEHCONTRCOHRTD
00016
00017
00018
00019
00020 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 5
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Trachea + + + + + 5
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + 5.........................................................................................................................................................................................................
Harderian Gland + + + + + 5Degeneration 3 1 3.0Inflammation 3 1 3.0Regeneration 3 1 3.0
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + 5.........................................................................................................................................................................................................
Urinary Bladder + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
VEHCONTRCOHRTD
00016
00017
00018
00019
00020 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 6
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ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + 5.........................................................................................................................................................................................................
Liver + + + + + 5Basophilic Focus X 1Inflammation 1 1 1.0
.........................................................................................................................................................................................................
Oral Mucosa + + + + + 5.........................................................................................................................................................................................................
Pancreas + + + + + 5.........................................................................................................................................................................................................
Salivary Glands + + + + + 5Right, Submandibular Gland, Regeneration 1 2 1 1 1 5 1.2
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
2-8ADHAQP1COHTD
00041
00042
00043
00044
00045 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 7
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.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + 5.........................................................................................................................................................................................................
Stomach, Glandular + + + + + 5.........................................................................................................................................................................................................
Tongue + + + + + 5
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Blood Vessel + + + + + 5.........................................................................................................................................................................................................
Heart + + + + + 5Cardiomyopathy 1 1 1 3 1.0
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + 5.........................................................................................................................................................................................................
Adrenal Medulla + + + + + 5.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + 5.........................................................................................................................................................................................................
Parathyroid Gland + + + + + 5.........................................................................................................................................................................................................
Pituitary Gland + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
2-8ADHAQP1COHTD
00041
00042
00043
00044
00045 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 8
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.........................................................................................................................................................................................................
Thyroid Gland + + + + + 5
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + 5.........................................................................................................................................................................................................
Preputial Gland + + + + + 5.........................................................................................................................................................................................................
Prostate + + + + + 5.........................................................................................................................................................................................................
Seminal Vesicle + + + + + 5.........................................................................................................................................................................................................
Testes + + + + + 5
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + 5.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M 0.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
2-8ADHAQP1COHTD
00041
00042
00043
00044
00045 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 9
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.........................................................................................................................................................................................................
Spleen + + + + + 5.........................................................................................................................................................................................................
Thymus + + + + + 5
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland M + M + + 3.........................................................................................................................................................................................................
Skin + + + + + 5
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + 5
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + 5
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + 5.........................................................................................................................................................................................................
Nose + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
2-8ADHAQP1COHTD
00041
00042
00043
00044
00045 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 10
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.........................................................................................................................................................................................................
Trachea + + + + + 5
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + 5.........................................................................................................................................................................................................
Harderian Gland + + + + + 5
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + 5Nephropathy 1 1 1.0
.........................................................................................................................................................................................................
Urinary Bladder + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
2-8ADHAQP1COHTD
00041
00042
00043
00044
00045 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 11
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ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + 5Hemorrhage 3 4 2 3.5
.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + 5.........................................................................................................................................................................................................
Liver + + + + + 5.........................................................................................................................................................................................................
Oral Mucosa + + + + + 5.........................................................................................................................................................................................................
Pancreas + + + + + 5.........................................................................................................................................................................................................
Salivary Glands + + + + + 5Right, Submandibular Gland, Inflammation 1 1 1.0Right, Submandibular Gland, Regeneration 1 1 1 1 1 5 1.0
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
8-9ADHAQP1COHTD
00066
00067
00068
00069
00070 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 12
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.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + 5.........................................................................................................................................................................................................
Stomach, Glandular + + + + + 5.........................................................................................................................................................................................................
Tongue + + + + + 5
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Blood Vessel + + + + + 5.........................................................................................................................................................................................................
Heart + + + + + 5Cardiomyopathy 1 1 1 3 1.0
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + 5.........................................................................................................................................................................................................
Adrenal Medulla + + + + + 5.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + 5.........................................................................................................................................................................................................
Parathyroid Gland + + + + + 5.........................................................................................................................................................................................................
Pituitary Gland + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
8-9ADHAQP1COHTD
00066
00067
00068
00069
00070 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 13
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.........................................................................................................................................................................................................
Thyroid Gland + + + + + 5
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + 5.........................................................................................................................................................................................................
Preputial Gland + + + + + 5.........................................................................................................................................................................................................
Prostate + + + + + 5.........................................................................................................................................................................................................
Seminal Vesicle + + + + + 5.........................................................................................................................................................................................................
Testes + + + + + 5
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + 5.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M 0.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
8-9ADHAQP1COHTD
00066
00067
00068
00069
00070 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 14
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.........................................................................................................................................................................................................
Spleen + + + + + 5.........................................................................................................................................................................................................
Thymus + + + + + 5
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland M + + + M 3.........................................................................................................................................................................................................
Skin + + + + + 5
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + 5
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + 5
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + 5.........................................................................................................................................................................................................
Nose + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
8-9ADHAQP1COHTD
00066
00067
00068
00069
00070 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 15
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.........................................................................................................................................................................................................
Trachea + + + + + 5
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + 5.........................................................................................................................................................................................................
Harderian Gland + + + + + 5
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + 5.........................................................................................................................................................................................................
Urinary Bladder + + + + + 5Mucosa, Hyperplasia 2 1 2.0
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
8-9ADHAQP1COHTD
00066
00067
00068
00069
00070 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 16
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ALIMENTARY SYSTEM.........................................................................................................................................................................................................
Esophagus + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Cecum + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Colon + + + + + 5.........................................................................................................................................................................................................
Intestine Large, Rectum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Duodenum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Ileum + + + + + 5.........................................................................................................................................................................................................
Intestine Small, Jejunum + + + + + 5.........................................................................................................................................................................................................
Liver + + + + + 5Inflammation 1 1 2 1.0
.........................................................................................................................................................................................................
Oral Mucosa + + + + + 5.........................................................................................................................................................................................................
Pancreas + + + + + 5Acinus, Atrophy 2 1 2.0
.........................................................................................................................................................................................................
Salivary Glands + + + + 4Right, Submandibular Gland, Regeneration 1 2 1 1 4 1.3
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
2-11ADHAQP1COHTD
00091
00092
00093
00094
00095 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 17
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.........................................................................................................................................................................................................
Stomach, Forestomach + + + + + 5.........................................................................................................................................................................................................
Stomach, Glandular + + + + + 5.........................................................................................................................................................................................................
Tongue + + + + + 5
CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................
Blood Vessel + + + + + 5.........................................................................................................................................................................................................
Heart + + + + + 5Cardiomyopathy 1 1 1 3 1.0
ENDOCRINE SYSTEM.........................................................................................................................................................................................................
Adrenal Cortex + + + + + 5.........................................................................................................................................................................................................
Adrenal Medulla + + + + + 5.........................................................................................................................................................................................................
Islets, Pancreatic + + + + + 5.........................................................................................................................................................................................................
Parathyroid Gland + + + + + 5.........................................................................................................................................................................................................
Pituitary Gland + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
2-11ADHAQP1COHTD
00091
00092
00093
00094
00095 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 18
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.........................................................................................................................................................................................................
Thyroid Gland + + + + + 5
GENERAL BODY SYSTEMNONE
GENITAL SYSTEM.........................................................................................................................................................................................................
Epididymis + + + + + 5.........................................................................................................................................................................................................
Preputial Gland + + + + M 4.........................................................................................................................................................................................................
Prostate + + + + + 5.........................................................................................................................................................................................................
Seminal Vesicle + + + + + 5.........................................................................................................................................................................................................
Testes + + + + + 5
HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................
Bone Marrow + + + + + 5.........................................................................................................................................................................................................
Lymph Node, Mandibular M M M M M 0.........................................................................................................................................................................................................
Lymph Node, Mesenteric + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
2-11ADHAQP1COHTD
00091
00092
00093
00094
00095 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 19
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.........................................................................................................................................................................................................
Spleen + + + + + 5.........................................................................................................................................................................................................
Thymus + + + + + 5
INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................
Mammary Gland M + + + M 3.........................................................................................................................................................................................................
Skin + + + + + 5
MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................
Bone + + + + + 5
NERVOUS SYSTEM.........................................................................................................................................................................................................
Brain + + + + + 5
RESPIRATORY SYSTEM.........................................................................................................................................................................................................
Lung + + + + + 5.........................................................................................................................................................................................................
Nose + + + + + 5
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
2-11ADHAQP1COHTD
00091
00092
00093
00094
00095 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
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.........................................................................................................................................................................................................
Trachea + + + + + 5
SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................
Eye + + + + + 5.........................................................................................................................................................................................................
Harderian Gland + + + + + 5
URINARY SYSTEM.........................................................................................................................................................................................................
Kidney + + + + + 5.........................................................................................................................................................................................................
Urinary Bladder + + + + + 5
*** END OF MALE DATA ***
*** END OF REPORT ***
TDMS No. 20537 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 09/10/2009
Test Type: 90-DAY Adenoviral Vector (AdhAQP1) Time Report Requested: 09:42:14
Route: INTRADUCTAL CANNULATION CAS Number: ADNVIRVECAQP First Dose M/F: 07/18/05 / NA
Species/Strain: RATS/F 344/N Lab: MBA
DAY ON TEST0057
0057
0057
0057
0057
.................................................................................................................................................................
FISCHER 344 RATS MALEANIMAL ID
2-11ADHAQP1COHTD
00091
00092
00093
00094
00095 * TOTALS
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked
Page 21