p580 mujovic and fisher vol. 191
TRANSCRIPT
P580 MUJOVIC AND FISHER Vol. 191
the Sixth Annual Metting of the American Soci-ety of Nephrology, Washington, p. 59, 1973.
KURATOWSKA, Z., LEWARTOWSKI, B. AND MICHALAK,
E. : Studies on the production of erythropoietinby the isolated hypoxic kidney. Bull. Acad. Pol.Sci. 8: 77-80, 1960.
Kuiw�owsic�, Z., LEwARTOWSKI, B. AND MICHALAK,E. : Studies on the production of erythropoietinby isolated perfused organs. Blood J. Hema-tol. 18: 527-539, 1961.
LEE, J. B., CROWSHAW, K., TAKMAN, B. H., ALLREP,K. A. AND GOUGOUTAS, J. Z. : The identification ofprostaglandin E�, F2 and A2 from rabbit kidneymedulla. Biochem. J. 105 : 1251-1260, 1967.
L0NIGR0, A. J., ITsKovrrz, H. D., CROWSHAW, K.AND MCGIFF, J. C. : Dependency of renal bloodflow on prostaglandin synthesis in the dog. Circ.Res. 32 : 712-717, 1973.
MCGIFF, J. C., CROWSHAW, K. J., TERRAGNO, N. A.,L0NIGR0, A. J., STRAND, J. C., WILLIAMSoN, M. A.,LEE, J. B. AND Nc, K. K. F. : Prostaglandin-like
substances appearing in canine renal venousblood during renal ischemia. Circ. Res. 27 : 765-782, 1970a.
MCGIFF, J. C., CROWSHAW, K., TERRAGNO, N. A.AND L0NIGR0, A. J. : Release of a prostagiandin-like substance into renal venous blood in responseto angiotensin II. Circ. Res. 26 and 27: suppi. I,121-130, 1970b.
MCGIFF, J. C., CROw5HAW, K., TERRAGNO, N. A.,MALIK, K. U. AND L0NIGR0, A. J. : Differential ef-feet of noradrenaiine and renal nerve stimulationon vascular resistance in the dog kidney and therelease of prostaglandin E-like substance. Ciin.Sci. 42: 223-233, 1972.
Statement of Ownerehip, Management and Circulation requiredby the Act of October 23, 1962; Section 4369, Title 39, UnitedStat� Code.1. DaIs ofFiting: October 1, 1974.2. Title of Publication: Journal of Pharmacology & Experi.
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MUIRHEAD, E. E., LEACH, B. E., GERMAIN, G. S.,BYERS, L. W. AND ARMSTRONG, F. B., JR. : Effect
of indomethacin on antihypertensive lipids de-rived from renomedullary interstitial cells grownin tissue culture. Fed. Proc. 33 : p. 339 Abs, 1974.
PAULO, L. G., WILKERSON, R. D., Rou, B. L.,GEORGE, W. J. AND FISHER, J. W. : The effects ofprostaglandin E1 on erythropoietin production.Proc. Soc. Exp. Biol. Med. 142 : 771-775, 1973.
RODGERS, G. M., GEORGE, W. J. AND FISHER, J. W.:Increased kidney cyclic AMP levels and erythro-poietin production following cobalt administra-tion. Proc. Soc. Exp. Biol. Med. 140: 977-981,1972.
ScilooLEy, J. C. AND MAHLMANN, L. J. : Stimulationof erythropoiesis in plethoric mice by prosta-glandins and its inhibition by anti-erythropoietin.Proc. Soc. Exp. Biol. Med. 138: 523-524, 1971.
SNEDECOR, G. W. : Statistical Methods, 5th ed.,Iowa State College Press, Ames, 1959.
STRONG, C. G., BOUCHER, R., NOWACZYNSKI, W. AND
GENEST, J. : Renal vasodepressor lipid. MayoCiin. Proc. 41 : 433-452, 1966.
TAKAKU, F., HIRASHIMA, K. AND NAKAO, K. : Stud-ies on the mechanism of erythropoietin produc-tion. I. Effect of unilateral constriction of therenal artery. J. Lab. Gun. Med. 59 : 815-820,1962.
VANE, J. R. : Inhibition of prostagiandin synthesisas a mechanism of action for aspirin-like drugs.Nature New Biol. 231 : 232-235, 1971.
WERNINO. C., VErrER. W., WEIDMAN, P., ScHwEI-
KERT, H. U., STIEL, D. AND SIEGENTHALER, W.:Effect of prostaglandin E1 in renin in the dog.Amer. J. Physioi. 220: 852-856, 1971.
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581
INDEX
Volume 191, October-December 1974
Acetyichoiine
action on isolated basilar, coroi�ary and mesen-
teric arteries of dog, 139increased sensitivity of sinoatrial pacemaker at
onset of autonomic neuroeffector transmissionin chick embryo heart. to, 479
neocortical, release, relation to tolerance to and
physical dependence on morphine in cats, 189
reactivity of chick embryo heart during onto-
genesis to, 109Acetyistrophant hidin , effect on systolic t lIne
intervals in nonfailing human heart, 487
Aconit inc-induced automaticity in in vitro cat nlyocardiai
preparations, effects of refractory period pro-
longat.ion, reduced sodium and tetrodotoxin,232
‘‘Active iodine,’’ thyroidal, reaction of N-iodo-succiilimide and of N-iodophtalimide with
t.hiocarhamide goitrogens as model of, 341Adrenergic neurons (see Neurons, adrenergic)
Adrenergic nerve (see Nerve , adrenergic)
Adrenergic receptor blockade, beta, by tolainolol,496
Adriamycin, disposition in rabbit, 331
Age-related changes in vascular responsiveness to
cyclic nucieotides and contractile agonists, 147
AHR -2666 �3-(rn-ch1orophenoxy)-1-methyicarba-nloylpyrrolidinei, site of action in frog sar-
torius muscle, fl6Albumin, binding capacity in renal disease, 318Allen, J. C., see Schwartz, A., 119Allopurinol, role in pharmacologic regulation of
purine biosynthesis in Burkit.t lymphoma andEhriich ascites tumor cells, 1
Altura, B. M. and Alt.ura, B. T. : Contractile ac-t.ions of antihist.amines on isolated arterial
smooth muscle, 262
Altura, B. T., see Altura, B. M., 262Amine pumps, in adrenergic neurons of rabbit
aorta and in rat cortical synapt.osomes, phenyirings of t.ricyclic compounds as determinants
of potency of inhibition of, 418Ammonia, synergism with fatty acids in produc-
tion of conla, implications for hepatic coma, 10Amphetamine, tolerance and metabolism, inhibi-
tion by propranoioi, 68d-Amphetamine , effects on si ngie vest ibuiar neti-
rons, 377
d- and i-Amphetamine, differential action, in-
creased fixed-ratio performance and, follow-
ing norepinephriiie depict ion by intraven-
tricular 6-hydroxydopamine, 349Anagnoste, B., Shirron, C., Friednlan, E. and
(.�oldstein, i�l. : I�ffeet of dihutyryl cyclic
adenosine monophosphate on ‘ 4C-dopami nebiosynthesis in rat brain striatai slices, 370
Analogs, cardenolide , new series (senliSynt het.icanalogs of digitoxigenin) , cardiotunic isc-
tivity, 219
Anderson, H. J. and Raines, A. : Suppression by
diphenyihydantoin of afferen t discharges
arising in muscle spindles of the triceps surae
of the cat, 290
Anderson, W., Jr., see Maling, H. M., 300Antiarrhythnlic properties, of tolamolol, 496
Antihistanlines, contractile actions on isolated
arterial snloot h muscle , 262Arrhyt hmias, cardiac , induced by hypothalamic
stimulation , effect of diphenylhydantoin and
lidocaine on, 506
Arteriesisolated basilar, coronary and nlesenteric, dog,
action of vasodilating drugs on, 139isolated tihiai, differential effect of metabolic
inhibitors on myogenic tone and contractility
in, 458
Atriaisolated, effects (.)f tricyclic conlpounds on hista-
mine response of, 232
guinea pig, effect of cardenolide analogs on, 219Azarnoff, D. L., see Shoenlan, I). W., 68
Azide, effect Ofl Illyogenic tone and contractility
iii isolated tihial arteries, 458
Bachur, N. R., Hhldebrand, H. C. and Jaenke,B . S. ; Adrianlycin and daunorubicin disposi-
tion ifl the rai)bit, 331Bagweii, E. E., Custy, J., Steen, II. G. and New-
man, W. H. : Beta receptor blocking and anti-arrhythmic properties of tolamolol, 496
Barnes, E., see Cubeddu, L., X., 444
Bates, T. H., see Tembo, A. V., 33
Behavioral nlodulltt loll , of cardiovascular effects
of l-norepinephrine in squirrel monkey, 269
Berkowitz, B. A., Cerreta, K. V. and Spector, S.:The influence of physiologic and pharmaco-logic factors on the disposition of morphine
as deternlined by radioinlnlunoassay , 527Berkowitz, B. A., see Cohen, M. Lj., 147Besch, H. IL, Jr., see Watanahe, A. M., 241
582 INDEX Vol. 191
Bile
excreti()n into, metabolism and, of ethacrynic
acid, 548
excretion of cardiac glycosides in, effect of
microsomal enzyme inducers, 201Bile duct ligation, effects on hepatic excretory
function compared with two-thirds hepat.ec-
t.omy, 23Blood pressure, effect of inhibition of dopamine-
$-hydroxyia.se in peripheral tissues by 5-
dimethyldithiocarbamylpicolinic acid on, 384Blosser, J. C. and Catravas, G. N. : Action of re-
serpine in morphine-tolerant rats : Absence
of an antagonism of catecholamine depletion,284
Boublik, M., see Kuenzig, W., 32Boutagy, J., see Thomas, R., 219
Bradykinin, inflammation induced by, antag-onists, 300
Brain
developing, rat, thyroid hormone control of 5-hydroxytryptamine metabolism in, 72
rat., measurement of morphine by radioimmuno-assay in, 527
striatal slices, rat, effect of dibutyryl cyclic
adenosine monophosphate on ‘4C-dopaminebiosynthesis in, 370
Brody, M. J., see Greenberg, S., 458
Burcsu, J., see Maxwell, R. A., 418
Burkitt lymphoma cells, pharmacologic regula-tioli of purine biosynthesis in, 1
Burks, T. F. and Grubb, M. N. : Sites of acutemorphine tolerance in intestine, 458
Burns, J. J., see Kuenzig, 32
Carbamylcholi ne , reactivity of chick embryo heartduring ontogenesis to, 109
Cardiac glycosides (see Glycosides, cardiac)
Cardiovascular effects, of l-norepinephrine insquirrel monkey, behavioral modulation of,269
Cat(s)effect of d-amphetamine on single vestibular
neurons of, 377
effect of diphenylhydantoin and lidocaine on
cardiac arrhythmias induced by hypothalamicstimulation in, 506
isolated perfused heart, correlation betweeninotropic action of ouabain and Na+,K+�
adenosine t riphosphat.ase in , 119muscle spindles of triceps surae, suppression by
diphenyihydantoin of afferent discharges
from, 290myocardial preparat ions , effects of refractory
period prolongation, reduced sodium and
tetrodotoxin on aconit inc-induced tachy-eardia in, 232
relationship of effects of cocaine on responses to
adrenergic nerve St imulat ion to metabolic
fate of released norepinephrine in, 431
spleen, effects of papaverine on release of nor-epinephrine and dopamine-�3-hydroxylase by
nerve stimulation in, 444synergism between ammonia and fatty acids in
production of coma in, implications forhepatic coma, 10
tolerance to and physical dependence on mor-
phine related to neocortical acetyicholinerelease in, 189
Catechoiamine-depleting effects of reserpine, re-
sistance in morphine-tolerant rats to, 284
Catravas, G. N., see Biosser, J. C., 284
CellsBurkitt lymphoma and Ehrlich ascites tumor,
pharmacologic reguiat ion of purine biosynt.he-siS in, 1
endocrine-like, in rat st.(.)mach, effects of 6-
hydroxydopa on amine stores and amino aciddecarboxylase activities in, chemical, fluores-cence histochemicai and electron microscopicstudy, 92
Central nervous system (see Nervous system,
central)Cephaloridine transport in kidney, mechanism,
311
Cerami, A., see Leong, J. K., 60
Cerreta, K. V., see Berkowitz, B. A., 527Chahine, R. A., see Cohen, M. V., 487
Chemical study, of effects of 6-hydroxydopa onamine stores and amino acid decarboxylase
activities in endocrine-like cells in rat stom-
ach, 92
Chicken embryo heart.increased sensitivity of sinoatrial pacemaker to
acetyicholine and to catecholamines at onsetof autonomic neuroeffect.or transfllissiOn in,479
ontogenesis of adrenergic and cholinergic neuro-
effector transmission in, 468reactivit.y to cholinergic agonists during onto-
genesis, 109Chiorpheniramine, contractile actions on isolated
at.riai smooth muscle, 262
Chlorpromazine, effects on moderately and se-vereiy suppressed punished responding inpigeon, compared with morphine, 172
Choiestyramine, impairment. of dicumarol and
tromexan absorption in rats by , as potential
drug interaction, 33
Choline, high affinity transport into myenteric
plexus of guinea-pig intestine, 102
Clearance, biologic half-life and, as indices of in-
trinsic hepatic metabolism, 17
Cobalt, effects 011 rat kidney lysosomes, 564
1974 INDEX 583
Cohen, M. L. and Berkowitz, B. A. : Age-relatedchanges in vascular responsiveness to cyclic
nucieotides and contractile agonists, 147Cohen, I\iI. V., Chahine, H. A., Klein, M. 1). and
Gorlin, R. : The effect. of acetylstrophant.hidinOn systolic time intervals in the nonfailing
human heart, 487
Coma, SynergiSm between ammonia and fattyacids in production of, implications for
hepatic coma, 10Compound 48/80, inflammation induced by, an-
tagonists, 300Conney, A. H., see Pantuck, E. J., 45
Contractile actions, of antihistamines on isolatedarterial smooth muscle, 262
Contractile agonists, cyclic nucleotides and, age-related changes in vascular responsiveness to,
147
Contractility, myogenic tone and, in isolatedtibial arteries, differential effect of metabolicinhibitors, 458
Coraboeuf, E. and 1)eroubaix, E. : Effect of a
spironoiactone derivat ive , sodium canreno-
ate, on mechanical activities of isolated ratmyocardiunl, 128
Coret, I. A., see Hughes, M. J., 252
Cocaineeffects on responses to adrenergic nerve stimula-
tion, relationship to metabolic fate of re-leased norepinephrine, 431
-reinforced responding in rhesus monkeys,effects of dose tinder a fixed-ratio schedule, 179
Cubeddu, L. , X., Barnes, E. and Weiner, N. : Re-lease of norepinephrine and dopamine-il-hy-
droxylase by nerve stimulation. III. Effects of
papaverine, 444
Cucineli, S. A., see Faraj, B. A., 535Custy, J., see Bagwell, F. E., 496
Cyanate, effects on central nervous system, 60Cyanide
effect on myogenic tone and contractility in iso-lated tibial arteries, 458
poisoning, produced by nitroprusside via reac-
tion with hemoglobin, 557Cyclic nucleotides, contractile agonists and, age-
related changes in vascular responsiveness to,147
D600 , verapamil and, subceliular myocardiaieffects, comparison with propranolol, 241
Da Prada, M., see Enna, S. J., 164Daunorubicin, disposition in rabbit, 331Dayton, P. G., see Faraj , B. A., 535I)eroubaix, E., see Corahoeuf, E., 128
1)ibutyryl cyclic adenosine monophosphate , effect
on ‘4C-dopamine biosynthesis in rat brainstriat.al slices, 370
1)icunlarol, absorption in rats, inlpairnlent bycholestyramine as potential drug interaction,
531)iecke, F. P. J., see (.�reenberg, S., 4581)igitoxigenin , semisynthetic analogs (new series
of cardenolide analogs), cardiotonic activity,219
Digitoxin, effect of nlicrosomal enzyme inducerS on
biliarv excretion of, 201
1)igoxin, effect of nlicrosomal enzyme inducers onbiliary excretion of, 201
5-1 )inlet.hyidit hiocarbarnylpicolinie acid-induced
dopanline-j�-hydroxyiase inhibit ion in periph-eral tissues, effect on stress-induced ulcer,ethanol-induced sleep and blood pressure, 384
1)initrophenoi, effect 011 nlyogenic tolle and con-
tractility in isolated tibial arteries, 458I )iphenyihydantoin
effect on cardiac arrhythnlias induced by hypo-
thalamic stimulation, 506
suppression of afferent discharges from musclespindles of triceps surae of cat by , 290
1)iphenhydramine, contractile actions oti isolated
arterial SIlloOt.h muscle, 262Dog(s)
beta receptor blocking and antiarrhytilnlic prop-
erties of tolamolol in, 496
disposition of Sch 10595 in, 324intestine, sites of acute morphine tolerance in,
518isolated basilar, coronary and nlesenteric ar-
teries, action of vasodilating drugs (10, 139isolated tibial arteries, differential effect of
metabolic inhibitors on myogenic t one and
contractility in, 458kidney , possible role of prostagiandins in genera-
t i()Il of eryt hropoiet ill after renal artery con-
striction in, 575
metabolism anid biliary excretion of ethacrynicacid in, 548
nletabolism and disposit ion of lllet hyiphenidate-
‘4C in, 5351)oizaki, W. M. , see Zieve, F. J., 10
1)opanline, synthesis, increased, in neost.riatum
after inhibition cessation of impulse flow, 82
‘4C-Dopamine, biosynthesis in rat brain striataislices, effect of dibutyryl cyclic adenosinemonophosphate on, 370
1)opanline-f3-hydroxylase
in peripheral tissues, inhibition by 3-dinlethyidi-thiocarbanlylpicolinic acid , effect ()fl stress-induced ulcer, et hanoi -induced sleep and bloodpressure, 384
release by nerve stimulation, effects of l)aPa-
verine, 444
1)olllino, E. F. and Labreque, U., 189
l)owns, I). A. and Woods, J. H. : Codeine- and en-caine-reinforced responding in rhesus inon-
584 INDEX Vol. 191
keys : Effects of dose on response rates under
a fixed-ratio schedule, 179Dromgoole, S. H. : The binding capacity of albu-
mm and renal disease, 318Drug interaction, potential, impairment by cho-
lestyramine of dicumarol and tromexan ab-sorption in rats as, 53
Edema, induced by histanline, serotonin, brady-kinin and compound 48/80 in rat, antagonists,
300Ehrlich ascites tumor cells, pharmacologic regu-
lation of purine biosynthesis in, 1
Electron microscopic study, of effects of 6-hy-
droxydopa on amine stores and amino aciddecarboxylase activities in endocrine-like cells
in rat stomach, 92Enero, M. A., see Langer, S. Z., 431
Enna, S. J., Da Prada, M. and Pietscher, A. : Sub-cellular distribution of reserpine in bloodplatelets : Evidence for multiple poois, 164
Enzyme inducers
microsomal, effect on biliary excretion of cardiacglycosides, 201
microsomal, stimulation of development ofhepatic excretory mechanism for ouabain in
newborn rats with, 212Enzyme induction, effects on intestinal phenacetin
metabolism in rat, 45
Epinephrine, increased sensitivity of sinoatrialpacemaker at onset of autonomic neuroeffector
transmission in chick embryo heart to, 479Erythropoietin
generation by kidney after renal artery constric-
tion, possible role of prostaglandins, 575production in rat kidney lysosomes, effects of
cobalt and hypoxia on, 564Ethacrynic acid, metabolism and biliary excretion
of, 548
Evans, D. E. and Gillis, R. A. : Effect of diphenyl-
hydantoin and lidocaine on cardiac arrhyth-
mias induced by hypothalamic stimulation, 506
Faraj, B. A., Israili, Z. H., Perel, J. M., Jenkins,M. L., Holtzman, S. G., Cucinell, S. A. andDayton, P. G. : Metabolism and disposition of
methyiphenidate-’4C: Studies in man and ani-mais, 535
Fatty acids, synergism with ammonia in produc-
tion of coma, implications for hepatic coma, 10Fernholt, i%i., see Tune, B. M., 311
Ferris, R. i’�I., see Maxwell, R. A., 418Fisher, J. W.
see Mujovic, V. M., 575see Smith, R. J., 564
Fitzgerald, T. J., see Kiaassen, C. D., 548Fixed-ratio performance, increased, differential
d- and i-amphetamine action and, following
norepinephrine depletion by intraventricular6-hydroxydopamine, 349
Fluorescence histochemical study, of effects of 6-hydroxydopa on amine stores and amino acid
decarboxyla,se activities in endocrine-like cellsin rat stomach, 92
Fluoroacetate, effect on myogenic tone and con-
tractility in isolated tibial arteries, 458Friedman, E., see Anagnoste, B., 370Frog, sartorius muscle, site of action of AHR-2666
in, 156
Gelbart, A., see Thomas, R.., 219
Gibaldi, M., see Perrier, D., 17Gillis, R. A., see Evans, D. E., 506Gilsdorf, R. B., see Zieve, F. J., 10
Gland submaxillary, rat, changes in neuronal up-take and metabolism of and sensitivity tonorepinephrine during degeneration secretionin, 403
Glycosides, cardiac, effect of microsomal enzymeinducers on biliary excretion of, 201
Goitrogens , t hiocarbanlide , reaction of N-iodo-
succimide and of N-iodophtalimide with, asmodels of thyroidal “active iodine,” 341
Goldberg, S. R., see Kelleher, R. T., 269Goldstein, M., see Anagnoste, B., 370
Gorlin, R., see Cohen, M. V., 487
Grady, R. W., see Leong, J. K., 60
Graziano, J. H., see Leong, J. K., 60Greenberg, S., Heitz, D. C., Brody, M. J., Wilson,
W. R., Diecke, F. P. J. and Long, J. P. : Differ-ential effect of metabolic inhibitors on myo-genie tone and contractility in isolated tibialarteries, 458
Grubb, M. N., see Burks, T. F., 518
Guinea pig(s)atria, effect of cardenolide analogs on, 219heart, effects of verapamil and D600 compared
with propranolol, 241
myenteric plexus of intestine, high affinity trans-port of choline into, 102
normal and phenobarbital-treated , perinatal
drug metabolism and morphological changes
in hepatocytes of, 32
H�kanson, R., Larsson, L.-I. and Sundler, F. : En-docrine-like cells in rat stomach : Effects of 6-hydroxydopa on amine stores and amino acid
decarboxylase activities , a chemical, fluores-cence histochemical and electron microscopicstudy, 92
Half-life, biologic, clearance and, as indices of in-
trinsic hepatic metabolism, 17Hara, F., see Hidaka, H., 384
Harada, N., see Hidaka, H., 384Hashizume, Y., see Hidaka, H., 384
1974IN I)EX 585
Kamm, J. J., see Kuenzig, W., 32
Heart. (s)
cat, arrhythmias induced by hypothalamicstimulation, effect of diphenylhydantoin and
lidocaine, 506
chick embryo, increased sensitivity of sinoatrial
pacemaker to acetyicholine and to catechol-amines at onset of autc)nomic neuroeffector
transmission in, 479chick embryo, ontogenesis of adrenergic and
cholinergic neuroeffector t ransmission in , 468
chick embryo, reactivity t.o choiinergic agonistsduring ontogenesis, 109
guinea pig, effects of verapamil and 1)600 corn-
pared with propranoiol, 241
human , nonfailing, effect of acet.ylstrophanthi-din on systolic time intervals in, 487
isolated perfused, rabbit and cat., correlation be-
tween inotropic action of ouabain and Na+,K�-adenosine triphosphatase in, 119
3H-norepinephrine uptake, blockade by 4-phen-yl-1 -arninotetralifles , implications for activeconformation of inlipramine-like drugs, 393
rat, effect. of sodium canrenoate on mechanical
and electrical activities of, 128Heidger, P. M., see Smith, R. J., 564Heitz, D. C., see Greenberg, S., 458
Hemoglobin, nitroprusside production of cyanide
poisoning via reaction with, 557Hepatectomy, two-thirds, effects on hepatic cx-
cret.ory function compared with bile duct. liga-t.ion, 25
Hepatic microsomal Illixed-funct.ion oxidase sys-tems, development in guinea pig, 32
Hepatocytes , of normal and phenobarbit.ai-t reated
guinea pigs, perinatal drug metabolism andmorphological changes in, 32
Herbert, J., see Leong, J. K., 60Herd, J. A., see Kelleher, R. T., 269Hexobarbital, narcosis and metabolism in mice,
stimulus control of, 358
Hidaka, H., Hara, F., Harada, N., Hashizume, Y.
and Yano, M. : Selective inhibition of dopa-mine-�3-hydroxylase in the peripheral tissues
by 5�dimethyldithiocarbamYlPic0ii11ic acid; itseffect on stress-induced ulcer, ethanol-induced
sleep and blood pressure, 384Hildebrand, 14. C., see Bachur, N. It., 331Histamine
inflammation induced by, antagonists, 300response of isolated atria, effects of tricyclic
compounds on, 252Holtzman, S. (4., see Faraj , B. A., 535
Hormone, thyroid, control of 5-hydroxytrypta-
mine metabolism in developing rat brain by,
72
Hsiao, K-C., see Pantuck, E. J.,45
Hughes, M. J. and Coret, I. A. : Effects of tricyclic
compounds on the histamine response of iso-lated atria, 252
6-Hydroxydopa, effects on amine stores and amino
acid decarboxylase activities in endocrine-likecells in rat stomach, chemical, fluorescence
histochemical and electron microscopic study,92
6-Hydroxydopamine , intraventricular, increasedfixed-ratio performance and differential d- andi-amphetamine action following norepineph-
rine depletion by, 3495-Hydroxytryptamine (see also Serotonin), me-
tabolism in developing rat brain, thyroid hor-mone control of, 72
Hypoxia, effects on rat kidney lysosomes, 564
Ignarro, L. J., see Smith, H. J., 564
Imiprannine
effect of subcellular distribution of reserpine inblood platelets, 164
-like drugs, implications for active conformation
of, 393
Indocyanine green, excretion in rats, comparisonof effects of two-thirds hepat.ectoiny and bile
duct ligation on, 25Indomethacin, effects on erythropoietin produc-
tion in dogs after renal artery constriction, 575Intestine
guinea pig, rnyenteric plexus, high affinity tranS-port of choline into, 102
rat, effects of enzyme induction on phenacetinmetabolism in, 45
sites of acute morphine tolerance in, 518N-Iodophtaiimide, reaction with thiocarbamide
goitrogens, as model of thyroidai “active io-dine,” 341
N-Iodosuccinimide , react ion with thiocarbamidegoitrogens, as model of thyroidal “active io-dine,” 341
Isoproterenol
action on isolated basilar, coronary and mesen-
teric arteries of dog, 139increased sensitivity of sinoatrial pacemaker at
onset of autonomic neuroeffect.or transmission
in chick embryo heart., 479
Israili, Z. H., see Faraj, B. A., 535
Jaenke, H. S., see Bachur, N. it., 331Jenkins, F., see Kuenzig, W., 32
Jenkins, M. L. , see Faraj , B. A. , 535Jirousek, L. and Soodak, M. : Studies of positive
iodine conlpounds as models of the thyroidal
“active iodine’ ‘ : Reaction of N-iodosuccini-mide and of N-iodopht.alimide with t.hiocarba-
mate goitrogens, 341
Judge, M., see Leong, J. K., 60
586 INDEX Vol. 191
Kaplan, S. A., see Pantuck, E. J., 45
Kelleher, R. T., Morse, W. H., Goldberg, S. H. andHerd, J. A. : Behavioral modulation of thecardiovascular effects of l-norepinephrine in
the squirrel monkey, 269Kidney
disease, binding capacity of albumin in, 318dog, possible role of prostaglandins in generation
of erythropoietin after renal artery constric-
tion by, 575mechanism of cephaloridine transport in, 311
rat, iysosomes, effects of cobalt on, 564Kirsten, E. B., Schoener, E. P. and Wang, S. C.:
Effects of d-anlphetamine on single vestibular
neurons, 377Kirsten, E. B., see Lustig, K. C., 156
Klaassen, C. D. : Comparison of the effects of two-thirds hepatectomy and bile duct ligation onhepatic excretory function, 25
Klaassen, C. 1). : Effect of microsonlal enzyme in-ducers on the biliary excretion of cardiac gly-cosides, 210
Klaassen, C. 1). : Stimulation of the developmentof the hepatic excretory mechanism for oua-
bain in newborn rats with microsomal enzymeinducers, 212
Kiaassen, C. 1). and Fitzgerald, T. J. : Metabolism
and biliary excretion of ethacrynic acid, 548Klein, M. 1)., see Cohen, M. V., 487
Koe, B. K. , see Sarges, H . , 393Kruszyna, H., see Smith, R. P., 557Kuenzig, W., Kamm, J. J., Boublik, M., Jenkins,
F. and Burns, J. J. : Perinatal drug metabolismand morphological changes in the hepatocytesof normal and phenoharhi t al-treated guinea
pigs, 32
Kuntzman, II., see Pantuck, E. J., 45
Labreque, U. and 1)onlino, E. F. : Tolerance to
and physical dependence on nlorphine : Rela-tion to neocortical acet.ylchoiine release in thecat, 189
Lal, H., see Roffman, M., 358Langer, S. Z. and Enero, M. A. : The potent.iation
of responses to adrenergic nerve stimulationin the presence of cocaine: Its relationship tothe metabolic fate of released norepinephrine,431
Leong, J. K., (.�rady, R. W., Herbert., J., (iraziano,J. H., Cerami, A., Judge, 1\I. and Quarternlain,D. : Pharmacology of cyanate. III. Effects on
the central nervous system, 60
Lidocaine, effect on cardiac arrhythmias inducedby hypothalamic stimulation, 506
Liver
excretory function, comparison of effects of two-
thirds hepatectomy and bile duct ligation on,25
intrinsic lfletabOliSflTl of drugs, clearance alid
biologic half-life as indices of, 17newborn rats, excretory mechanism for ouabain
in, stiniuiation with microsomai enzyme in-
ducers, 212
L#{246}ffeiholz, K. and Pappano, A. J. : Increased sensi-
tivity of sinoatriai pacemaker to acetyicholine
and to catecholamines at the onset of auto-nomic neuroeffector transmission in chick em-
bryo heart, 479L#{246}ffelholz, K., see Pappano, A. J., 468
Long, J. P., see Greenberg, S., 458Lustig, K. C. and Kirsten, E. B. : The site of ac-
t.ion of AHR-2666 in frog sartorius muscle, 156
Lysosornes, rat kidney, effects of cobalt. on, 564
Maling, H. M. , Webster, M. E., Williams, M. A.,Saul, W. and Anderson, W., Jr: Inflammationinduced by histamine, serot.onin, bradykinin
and compound 48/80 in the rat : Antagonists
and mechanisms of action, 300Man
binding capacity of albumin and renal diseasein, 318
disposition of Sch 10595 in, 324
metabolism and disposition of met hylphenidate-
‘�C in, 535nonfailing heart , effect of acetyistrophanthidin
Oil systolic tinle intervals in, 487
Maxwell, R. A., Ferris, R. M., Burcsu, J., Wood-ward, E. C., Tang, 1). and Wiliiard, K. : Thephenyl rings of tricyelic antidepressant.s andrelated compounds as determinants of thepotency of inhibition of the amine pumps inadrenergic neurons of the rabbit aorta and in
rat cortical synaptosomes, 418Metabolic inhibitors, differential effect on nlyo-
genie tone and contractility in isolated t.ibial
arteries, 458Metabolism
biliary excretion and, of ethacrynic acid, 548disposition and , of methylphenidate-’4C in man
and animals, 535drug, perinatal, and morphological changes in
hepat.ocytes of normal and phenobarbital-
treated guinea pigs, 32hepatic, intrinsic, clearance and biologic half-
life as indices of, 17
intestinal, of phenacetin in rat., effects of en-zyrne induction,45
of adriamycin and daunorubicin in rabbit, 331of hexobarhital, narcosis and, stimtilus control
iLl nlice of, 358
of 5-hydroxytryptanline in developing rat
brain, control by thyroid hormone, 72
of released norepi nephrine , relat ionship toeffects of cocaine on responses to adrenergic
nerve stimulation, 431
1974 INDEX 587
tolerance and, of amphetamine, inhibition bypropranoloi, 68
3-Methylcholanthrene
effect on biliary excretion of cardiac glycosides,201
stimulation of hepatic excretory mechanism forouabain in newborn rats by, 212
Methylphenidate-’4C
metabolism and disposition in man and animals,
535
Mice
metabolism and disposition of nlethylphenidate-i4C in, 535
nitroprusside production of cyanide poisoning
via reaction with hemoglobin in, 557
stimulus control of hexoharbit.al narcosis andmetabolism in, 358
Monkey(s)
disposition of Sch 10595 in, 324rhesus, effects of dose on rates of codeine- and
cocaine-reinforced responding in, 179squirrel, behavioral modulation of cardiovascu-
lar effect.s in, 269Morphine
disposition deterini ned by radioimmunoassay,
influence of physiologic and pharmacologic
factors on, 527effect Ofl moderately and severely suppressed
punished responding in pigeon, compared withchlorpromazine, 172
tolerance, acute, sites in intestine of, 518tolerance to and physical dependence on in cat,
relation to neocortical acetyichoiine release,
189-tolerant rats, resistance to catechoiamine-de-
plet.ing effects of reserpine in, 284
Morse, W. H., seeKelleher, R. T., 269Mujovic, V. M. and Fisher, J. W. : The effects of
indomethacin on erythropoietin production indogs following renal artery constriction. I.The possible role of prostagiandins in the
generation of erythropoietin by the kidney, 575Munson, R., see Schwartz, A., 119
Muscle(s)papillary, cat, effects of refractory period pro-
longation, reduced sodium and tetrodotoxinon aconitine-induced automaticity arid tachy-
cardia in, 232
sartorius, frog, site of action of AHR-2666 in, 156smooth, arterial, contractile actions of antihis-
tamines on, 262spindles of triceps surae of cat, suppression by
diphenyihydantoin of afferent discha rges from
209Myenteric plexus, of guinea-pig intestine, high
affinity transport. of choline into, 102Mvocardial effects, subcellular, of verapamil and
1)600 , comparison with propranolol, 241
Nlyogenic tone, contract ility arid, in isolated t.ibialarteries, differential effect of metabolic in-hibitors, 458
Na�, K+�Adenosi ne t riphosphatase , i nt.erac t. ion
with inotropic action of (.)uabain in isolated
perfused rabbit. and cat hearts, 119Naloxone-precipitated wi t hdrawal in morphine-
dependent cats, relation t.o neocorticai acetyl-
choline release, 189Narcosis, hexobarbitai, nletabolism and, stiniulus
control in mice of, 358Nerve, adrenergic, stimulation, effects of cocaine
on responses to, relationship to metabolic fate
of released norepinephrine, 431Nerve stimulation, effects of papaverine on release
of norepinephrine arid dopamine-�-hydroxyl-
ase by, 444Nervous system, central, effects of cyanate, 60Neuroeffector transmission
adrenergic and choiinergic, ontogenesis in chick
embryo heart , 468autonornic , in chick embryo heart , increased Sen-
sitivit.y of sinoatrial pacemaker to acetyicho-
line and to catecholannines at onset. of, 479Neurons
adrenergic, in rabbit aorta, phenyl rings of tn-
cyclic compounds as determinants of potencyof inhibition of amine pumps in, 418
dopaminergic , drug-induced antagonism of in-crease in tvrosine hvdroxviase activit.y pro-
duced by cessation of impulse flow in, 82vestibular, single, effects of (1-amphetamine on,
377
Newman, W. H., see Bagweil, E. E., 496
Nitroprusside, production of cyanide poisoning viareaction with hemoglobin, 557
Norepinephrineage-related changes in vascular responsiveness
to, 147changes in neuronai uptake and metabolism of
and sensitivity to, during degeneration secre-
tion in rat submaxillary gland, 403depict ion by mt raventnicular 6-hydroxydopa-
mine, increased fixed-ratio performance and
differential d- and i-amphetamine action fol-lowing, 349
release by nerve stimulation, effects of papa-
verine, 444
released, metabolic fate, relationship to effects of
cocaine on responses to adrenergic nerve stim-ulation, 431
3H-Norepinephrine, uptake, heart, blockade by 4-
phenyl-1 -aminotet ralines , implications foractive conformation of imipramine-like drugs,
393l-Norepiriephnine, cardiovascular effects in squirrel
monkey, behavioral modulation of, 269
588 INDEX Vol. 191
Ouabaineffect of niicrosomal enzyme inducers on biliary
excretion of, 210
excretion in rats, comparison of effects of two-thirds hepatectomy and bile duct ligation on,25
hepatic excretory mechanism for, in newborn
rats, stimulation with microsomal enzyme in-
ducers, 212inotropic action, interaction with Na+, K+�
adenosine triphosphatase in isolated perfused
rabbit arid cat hearts, 119
Pacemakersinoatnial, in chick embryo heart, effect of chol-
inergic agonists on, 109
sinoatnial, iii chick embryo heart, increased sen-
sitivity to acetylchoiine and to catecholamines
at. onset. of autonomic neuroeffect.or transmis-sion, 479
Pant.uck, E. J., Hsiao, K.-C., Kaplan, S. A.,
Kuntzman, II. and Conney, A. H. : Effects ofenzyme induction on intestinal metabolism
in the rat,45Papaverine
action on isolated basilar, coronary arid mesen-
teric arteries of dog, 139
effects on release of norepinephnine and dopa-rnine-�3-hydroxyiase by nerve stimulation, 444
Pappano, A. J. and Loffeiholz, K. : Ontogenesis ofadreniergic and cholinergic neuroeffector trans-
mission in chick embryo heart, 468Pappano, A. J. and Skowronek, C. A. : Reactivity
of chick embryo heart to cholinergic agonists
during ontogenesis : Decline in desensitizationat the onset of cholinergic transmission, 109
Pappano, A. J., see Loffelholz, K., 479Pence, C. J., see Stefano, F. J. E., 403
Penel, J. M. , see Faraj , B. A. , 535
Penner, 1). and Gibaidi, M. : Clearance and bio-logic half-life as indices of intrinsic hepaticmetabolism, 17
Pert, C. B. and Snyder, S. H. : High affinity trans-port of choline into the myenteric plexus of
guinea-pig intestine, 102
Peterson, D. W. and Sparber, S. B. : Increasedfixed-ratio performance and differential d-
and i-amphetamine action following norepi-nephrine depletion by intraventnicular 6-hy-
droxydopamine, 349Pharmacology of cyanate, 60Phenacetin, intestinal metabolism in rat, effects
of enzyme induction, 45
Phenobarbitaieffect on biliary excretion of cardiac glycosides,
201
stimulation of hepatic excretory mechanism for
ouabain in newborn rats by, 212
-treated and normal guinea pigs, perinatal drugmetabolism and morphological changes in
hepatocytes of, 32
4-Phenyl-1 -aminotetralines, blockade of heart 3H-
norepinephrine uptake by, implications foractive conformation of imipramine-iike drugs,
393Phenyl rings, of tnicyclic compounds, as determi-
nants of potency of inhibition of amine pumpsin adrenergic neurons of rabbit aorta arid in
rat cortical synaptosomes, 418Physical dependence, on morphine in cat, relation
to neocontical acetyicholine release, 189
Pigeon, comparison of morphine and chiorproma-zinc effects on moderately and severely sup-
pressed punished responding in, 172Plasma, rat., measurement of morphine by radio-
inimunoassay in, 527Platelets, blood, subceliular distribution of reser-
pine in, 164Pletscher, A., see Enna, S. J., 164
Poisoning, cyanide, produced by nit.roprusside via
reaction with hemoglobin, 557Polycythemia, cobalt , mechanism, 564Potassium chloride, age-related changes in vascu-
lar responsiveness to, 147
Pregnenoione-16a-carbonitrileeffect on biliary excretion of cardiac giycosides,
201
stimulation of hepatic excretory mechanism forouabain in newborn rats by, 212
Procainamide, excretion in rats, comparison of
effects of two-thirds hepatectomy and bile
duct. ligation on, 25Promethazine contractile actions on isolated arter-
ial smooth muscle, 262
Propranololinhibition of anlphetanline tolerance and me-
tabolism by, 68
subcellular myocardial effects , comparison Withverapanlil and 1)600 � 241
Prostagiandins, possible role in generation of
erythropoietin by kidney after renal artery
constriction, 575
Purine, biosynthesis , pharmacologic regulation inBurkitt lymphoma and Ehrlich ascites tumor
cells, 1Pyniianiine, contractile actions on isolated arterial
smooth muscle, 262
Q uarternlain, I)., see Leong, J. K., 69
Rabbit(s)aorta, phenyi rings of tricyclic compounds as de-
terminants of potency of inhibition of amine
pumps in adrenergic neurons of, 418
blood platelets , subceliular distribution of
reserpine in, 164
1974 INDEX 589
disposition of adriamycin and daunorubicin in,
331
isolated arterial smooth muscle, contractileactions of antihistamines on, 262
isolated atnia, effects of tnicyclic compounds on
histamine response of, 2,52isolated perfused heart , correlation between
inotropic action of ouabain and Na+, K+�adenosine triphosphatase in, 119
kidney, mechanism of cephaloridine transportin, 311
Radioimmunoassay, for disposition of morphine,527
Rastogi, R.. B. and Singhai, R. L. : Thyroid hor-mone control of 5-hydroxytryptainine meta-
bolism in developing rat brain, 72
Rat(s)
antagonists of inflammation induced by hista-
mine, serotonin, bradykinin and compound
48/80 in, 300aortic strips, responsiveness to cyclic nucieo-
tides and contractile agonists, age-related
changes in, 147
blockade of heart 3H-norepinephnine uptake by
4-phenyi-1-aminotetralines in, implications
for active conformation of inlipramine-like
drugs, 393brain, developing, thyroid hormone control of
5-hydroxytryptamine metabolism in, 72
brain st.niatal slices, effect of dibutyryl cyclic
adenosine monophosphate on ‘4C-dopanli ne
biosynthesis in, 370comparison of effects of two-thirds hepatectoniy
and bile duct ligation on hepatic excretoryfunction in, 25
cortical synaptosonies, phenyl rings of tricyclic
compounds of potency of inhibition of aminepumps in, 418
disposition of Sch 10395 in, 324
drug-induced antagonism of increase in tyrosinehydroxylase activity produced by cessation ofimpulse flow in dopaminergic neurons of, 82
effects of cyanate on central nervous system in,
60effects of enzyme induction on intestinal phen-
acet.in metabolism in, 45effect of inhibition of dopamine-j3-hydroxyiase
in peripheral tissues by 5-dimethyldithiocar-bamylpicolinic acid on stress-induced ulcer,
ethanol-induced sleep and blood pressure, 384
effect of microsonial enzyme inducers on biliary
excretion of cardiac glycosides in, 201
impairment by cholestyramine of dicumarol and
tromexan absorption as potential drug inter-
action in, 53
increased fixed-ratio performance and differen-
tial d- and i-amphetamine action following
norepinephrine depletion by intraventnicular
6-hydroxydopamine, 349
influence of physiologic and pharmacologic fac-
tom on disposition of morphine as determinedby radioimmunoa.ssay in , 527
inhibition of amphetamine tolerance and me-
tabolism by propranolol in, 68isolated myocardiurn, effect of sodium canreno-
ate on mechanical and electrical activities of,
128
kidney lysosomes, effects of cobalt on, 564
metabolism and biliary excretion of ethacrynic
acid in, 548metabolism and disposition of methylphenidate-
‘4C in, 535morphine tolerant, resistance to catecholanline-
depleting effects of reserpine in, 284newborn, development of hepatic excretory
mechanism for ouabain in, stimulation with
microsomal enzyme inducers, 212nitroprusside production of cyanide poisoning
via reaction with hemoglobin in, 557stomach, effects of 6-hydroxydopa on amine
stores and amino acid decarboxylase activities
in endocrine-like cells in, chemical, fluores-cence histochernical and electron microscopic
study, 92submaxillary gland, changes in neuronal uptake
and metabolism of and sensitivity to norepi-
nephrine during degeneration secretion in, 403Synergism between ammonia arid fatty acids in
production of coma in, implications for hepatic
coma, 10
Reem, G. : Pharmacologic regulation of the earlysteps of purine biosynthesis in Burkitt lym-phoma cells and in Ehriich ascites tumor cells,
Refractory period prolongation, effects on aconi-
tine-induced automaticity and tachycardia in
(‘at myocardial preparations, 232
Reserpineresistance in morphine-tolerant rats to cate-
cholamine-depleting effects of, 284subceiluiar distribution in blood platelets, cvi-
dence for niuitiple pools, 164
Responding
codeine- and cocaine-reinforced, in rhesus mon-keys, effects of dose on response rates underfixed-ratio schedule, 179
punished, moderately and severely suppressed,
in pigeon, comparison of morphine and chior-promazine effects on, 172
Roffman, M. and Lal, H. : Stimulus control of
hexobarbital narcosis and metabolism in mice,358
Roth, R. H., see Walters, J. R., 82Ruthenium red, effect on myogenic tone and con-
tractility in isolated tibial arteries, 458
.590 INDEX Vol. 191
201
Sarges, II., Koe, B. K., Weissman, A. and Schaefer,
J. P. : Blockade of heart ‘H-norepinephrine up-
take by 4-phenyl-1-azninotetralines : Implica-tions for the active conformation of imipra-
mine-like drugs, 393Sartonius muscle (see Muscle, sartorius)
Saul, W., see Maling, H. M., 300Sch 10595 [5-(n-butyi)-picoiinamide], disposition
in animals and man, 324Schaefer, J. P., see Sarges, H., 393
Schoener, E. P.,seeKirsten, E. B., 377Schwartz, A., Allen, J. C., Van Winkle, W. B. and
Munson, R. : Further studies on the correla-
tion between the inot.ropic action of ouabain
and its interaction with the Na�, K�-adeno-sine triphosphatase : Isolated perfused rabbit
and cat hearts, 119Schwartz, A., see Tune, B. M., 311
Serotonin (see also 5-Hydroxytryptatnine)
age-related changes in vascular responsiveness
to, 147
antagonists of inflammation induced by, 300Shirron, C., see Anagnoste, B., 370Shoeman, 1). W., Sirtoni, C. It. and Azarnoff, I).
L. : Inhibition of amphetamine tolerance andmetabolism by propranolol, 68
Singhal, R. L., see Rastogi, R. B., 72Sirtoni, C. R., see Shoeman, D. W., 68
Skowronek, C. A., see Pappano, A. J., 109
Sleep, ethanol-induced, effect of inhibition of
dopamine-�-hydroxyla.se in peripheral tissuesby 5-dimethyidithiocarbamylpicolinic acid on,
384Smith, H. J., Ignarro, L. J., Heidger, P. M., and
Fisher, J. W. : Lysosomal enzyme release in
vivo : An evaluation of the mechanism of cobaltpolycythemia, 564
Smith, R. P. and Kruszyna, H. : Nitroprussideproduces cyanide poisoning via a reaction with
hemoglobin, 557
Snyder, S. H., see Pert., C. B., 102Sodium , reduced , effects on aeon itine-induced
automaticit.y and tachycardia in cat myo-cardial preparations, 232
Sodium canrenoate (spironolactone derivative),
effect on mechanical and electrical activities
of isolated rat myocardium, 128Sodium nitrite, action on isolated basilar, coronary
and mesentenic arteries of dog, 139Sparber, S. B., see Peterson, D. W., 349Spector, S., see Berkowitz, B. A., 527Spironolact one
derivative (sodium canrenoate) , effect on me-
chanical and electrical activities of isolated
rat myocardium, 128
effect on biliary excretion of cardiac glycosides,
stimulation of hepatic excretory mechanism forouabain in newborn rats by, 212
Spleen, cat., effects of papaverine on release ofnorepiriephrine and dopamine-j3-hydroxylase
by nerve stimulation in, 444Staub, M., see Symchowitz, S., 324
Steen, IL G., see Bagwell, E. E., 496
Stefano, F. J. E., Pence, C. J. and Tumilasci, 0. R.:
Changes in neuronal uptake and metabolismof, and sensitivity to, norepinephnine during
the degeneration secretion in the rat submaxil-lary gland, 403
Stimulus control, of hexobarbital narcosis and
metabolism in mice, 358Stit.zer, M. : Comparison of morphine and chlor-
promazine effects on moderately and severely
suppressed punished responding in the pigeon,
172Stomach, rat, effects of 6-hydroxydopa on amine
stores arid amino acid decanboxyiase activitiesin endocrine-like cells in, chemical, fluores-cence histochemical and electron microscopic
study, 92Sulfobroniophthalein, excretion in rats, compari-
son of effects of two-thirds heptatectomy andbile duct ligation on, 25
Synichowitz, S. and Staub, M. : Disposition of Sch10595 in animals and man, 324
Systolic time intervals, in nonfailing human heart,
effect of acetylstnophandhidin on, 487
Tachycardia, aconitine-induced, in cat myocardial
preparations, effects of refractory period pro-longation , redu ced sodium and tetrodotoxin,
232Tang, I)., see Maxwell, H. A., 418Tanz, R. I). : Pharmacology of aconitine-induced
automaticity on in vitro cat myocardial prepa-rations. II. Effects of refractory period pro-longation, reduced sodium and tetrodotoxin,
232
Tembo, A. V. and Bates, T. H. : Impairment bycholestvnamine of dicumarol and tromexan
absorption in rats: A potential drug interac-tion, 53
Tetrodotoxin, effects on aconitine-induced auto-
mat.icity and tachycardia in cat myocardial
preparations, 232Thiocarbamides, goitrogenic, reaction of N-iodo-
succimide and of N-iodophtaiimide with, as
models of t.hynoidai “active iodine,” 341
Thomas, H., Boutagy, J. and Gelbart, A. : Car-
denolide analogs. V. Cardiotonic activity ofseniisvnthetic analogs of digitoxigenin, 219
Thyroid
“active iodine,” reaction of N-iodosuccinimideand of N-iodophtalimide with thiocarbamidegoitrogens as model of, 341
1974 INDEX 591
hormone , control of 5-hydroxytryptamine me -
tabolism in developing rat brain by, 72
Toda, N. : The action of vasodilating drugs on iso-iated basilar, coronary and niesenteric arteries
of the dog, 139Tolamolol, beta receptor blocking arid antiarrhy-
thmic properties of, 496Tolerance
to morphine in cat, relation to rieocort.icai acetyl-choline release, 189
to morphine, sites in intestine, 518Tnicyclic compounds
effect on histamine response of isolated atria, 252phenyl rings of, as determinants of potency of
inhibition of amine pumps in adrenergic neri-
nons of rabbit aorta and in rat cortical synap-
tosomes, 418
Tripelennanline, contractile actions on isolated
arterial smooth muscle, 262Tromexan, absorption in rats, impairment by
cholest.vraniine as potential drug interaction,
53
Tuniulasci, 0. R., see Stefano, F. J. E., 403
Tune, B. � , Fernholt, M. and Schwartz, A.:Mechanism of cephaloridine transport in thekidney, 311
Tyrosine hydroxyiase activity, increase in, pro-
duced by cessation of impulse flow in dopa-
minergic neurons, drug-induced antagonism
of, 82
Ulcer, stress-induced, effect of inhibition of dopa-
mine-�3-hydroxylase in peripheral tissues, by 5-dinlethyldithiocarbamylpicoiinic acid on, 384
Van Winkle, W. B., see Schwartz, A. , 119
Vascular responsiveness, to cyclic nucleotides and
contractile agonists, age-related changes, 147Vasodilating drugs, action on isolated basilar,
coronary and mesentenic arteries of the dog,
139Verapaniul, D600 and , subcellular nlyocardial
effects, comparison with propranolol, 241
Walters, J. R. and Roth, H. H. : l)opaminergic
neurons: I)rug-induced antagonism of the in-
crease in tyrosine hydroxylase activity pro-
duced by cessation of impulse flow , 82Wang, S. C., see Kirsten, E. B., 377
Watanabe, A. M., and Besch, H. 14., Jr. : Subcellu-lar myocardial effects of verapaniil and 1)roo:
Comparison wit h propranolol, 241
Webster, 1�1. E., see Maiing, H. M., 300
Weiner,N.,seeCubeddu,L., X., 444Weissrnan, A., see Sarges, B., 393
Williams, M. A., see Maling, H. M., 300Williard, K., see Maxwell, H. A., 418Wilson, W. H. , see Greenberg, S., 458
Wi t hdrawal syndrome , in niorphi ne-dependent
cats, relation to neocortieai acetyicholine re-lease, 189
Woodward, E. C., see Maxwell, R. A., 418
Yano, M., see Hidaka, H., 384
Zieve, F. J., Zieve, L., 1)oizaki, W. M. and Gus-dorf, R . B. : Synergism between ammonia andfatty acids in the production of coma: 1mph-
cations for hepat.ic coma, 10
Zieve, L., see Zieve, F. J., 10