pain anatomy and physiology
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painTRANSCRIPT
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PAIN
ANATOMY&PHYSIOLOGY
Dr. M.ANEEQUE ALAM
Anesthesia Resident
Department of Anesthesiology
Patel Hospital
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DEFINITION
Pain is unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.Ref: International Association for the Study of Pain(IASP)
o Pain is SUBJECTIVE phenomena
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NOCICEPTION
Nocioception is a complex sequence of actions
between tissue damage and the perception of
pain.Its includes
Transduction
Transmission
Modulation
Perception
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Transduction: Translation of a (chemical) pain
stimulus into electrical activity on nerve level.
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Transmission: Guidance of the pain – information
through the nervous system, including:
Ascending pathway
Primary afferent nerve-ends that go to the dorsal horn of
the spinal cord.
ascending (inter-) neurons that project their information
from the spinal cord to the brainstem and
the hypothalamus/thalamus
The thalamic-cortical pathways
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Modulation: Modification of the nociceptive
transmission through a number of humoral and
neural effects
anti-nociceptive pathways
(descending pathway)
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Perception: Observing the pain in
a conscious way. Integration of transduction,
transmission and modulation with the unique
psychology of the individual, resulting in a
subjective and emotional pain sensation
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Opioids
Local anesthetics
Opioids
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PAIN IS CLASSIFIED INTO NOCICEPTIVE, NEUROPATHIC AND
PSYCHOGENIC
1. Nociceptive is pain caused by tissue damage (inflammation)
which stimulate pain receptors (nociceptors).
2. Neuropathic: (pain due to injury of nerve pathway)
site of injury: Central Central pain (thalamic infarct).
Mixed Plexus avulsion, Post herpetic neuralgia.
Peripheral Neuroma, nerve compression, phantom, neuralgias.
character: burning, tingling, numbness, pressing, squeezing, itching, constant +/-
intermittent shooting, lancinating, electric.
3. Psychogenic: (difficult to differentiate whether secondary to or actual
cause of pain), anxiety, depression (30% of depressives complain of pain on initial
presentation).
CLASSIFICATION
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Nociceptors are special receptors that
respond only to noxious stimuli and generate
nerve impulses which the brain interprets as “pain”
Free nerve endings
oNon adaptive it’s a
protective function
to keep the individual
trying to remove the
damaging stimulus or
to get away from it.
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PRIMARY AFFERENT FIBERS
Aδ – fast
C – slow
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CHARACTERISTICS A DELTA FIBRES C-FIBRES
MYLENATION MYELINATED
LARGE DIAMETER
NON-MYLENATED
SMALL DIAMETER
CONDUCTION SPEED FAST(70-120 m/sec) SLOW(0.2-2 m/sec)
ONSET FIRST
FAST PAIN
SECOND
SLOW PAIN
DURATION BRIEF LONG
RECEPTIVE FIELD SMALL LARGE
LOCALIZATION PRECISE DIFFUSE
SENSORY QUALITY SHARP,PRICKING ACHING,DULL,
BURNING
CNS RESPONSE RELFEX,ANALYSIS EMOTIONAL,
SUFFERING
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TYPE OF PAIN
FAST PAIN
SLOW PAIN
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FAST PAIN SLOW PAIN
onset: during application of the stimulus Shortly after application if tissue damage
occurs
Duration: short duration Longer duration
Nature: pricking Burning
Afferent: A-delta fibers C-fibers
Neurotransmitter: glutamate Substance-P
Significance: * determine site & severity.
* Initiate withdrawal reflexes.
Associated with arousal, autonomic &
emotional reactions
Localization: well-localized Poorly-localized
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THE NEUROCHEMICALS OF PAIN
• Glutamate - Central
• Substance P - Central
• Brandykinin - Peripheral
• Prostaglandins - Peripheral
PAIN
INITIATOR
• Serotinin
• Endorphins
• Enkephalins
• Dynorphin
PAIN
INHIBITOR
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PAIN’S ASCENDING PATHWAY TO THE
BRAIN
THREE neurons from the receptor
to the cerebral cortex
First order neuron:
Cell body located in the
dorsal root ganglion.
Starts from free nerve ending
Ends at substantia gelatinosa
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Second order neuron: Has cell body in the
spinal cord ormedulla oblongata
• Starts from substantiagelatinosa
Axon decussate & Terminate on 3rd order
in thalamus neuron followingSpinothalamic tract
Third order neuron: Has cell body in thalamus Axon terminates on cerebral cortex ipsilaterally
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The Descending Pathway pain afferents stimulates the neurons in
periaqueductal gray (PAG) - gray matter
surrounding the cerebral aqueduct in the
midbrain results in activation of efferent anti-
nociceptive pathways
from there the impulses are transmitted
through the spinal cord to the dorsal horn
there thay inhibit or block transmission of
nociceptive signals at the level of dorsal horn
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GATE THEORY
Melzack & Wall (1965)
. non-painful input closesthe "gates" to painful input
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APPLICATIONS OF GATE THEORY
Stimulation of touch fibres for pain relief:
TENS (transcutaneous electrical nerve
stimulation)
Acupuncture
Massage
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PAIN TOLERANCE
It is the maximum intensity of pain can be tolerated by the
subject without obvious complaint.
Pain tolerance is affected by a number of factors:
- Anxiety, depression & fatigue ------> pain tolerance.
- rest, sever exercise & strong emotional excitement ------> pain tolerance.
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Hyperalgesia
AllodyniaPain due to a stimulus that does not
normally provoke pain.
Increased pain from a stimulus that
normally provokes pain
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PAIN FELT AWAY FROM THE ORIGINAL SITE OF THE
PAINFUL STIMULUS.
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PHANTOM LIMB
o sensations are described as
perceptions that an individual experiences
relating to a limb or an organ that is not
physically part of the body
o brain contains neuromatrix of the body image –neurosignature like a hologram
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QUESTIONS?