palliative care algorithms -...
TRANSCRIPT
April 2010
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
Palliative Care Algorithms
Thomas Palliative Care ServicesVCU Massey Cancer Center
VCU Health System
April 2010
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
3
Table of Contents
Approved for use on palliative care patient where written order states: “May use palliative care orders…”
Agitation 3
Alternative Route for Opioid Administration 4
Anorexia 5
Anuria 6
Bladder Spasms Treatment 7
Bowel treatment – stepped care program 8
Candidiasis – Oral 9
Candidiasis – Perineal 10
Dyspnea 11
Fever 12
Hiccough 13
Mucositis 14
Pruritus 15
Secretions 16
Seizures – Acute Management 17
Sleep Disturbance 18
Wound Odor 19
Name DateMedical Director, Thomas Palliative Care Unit
Name DateDirector, Nursing
April 2010 4
Agitation
Haloperidol 0.5 mg PO/IV/SC every 4 hours as needed
Continue same doseHaloperidol every 12 hrs scheduled
Evaluate to continue, taper or dc
Titrate up by 1 mg every 1 hour until desired effect achieved (1mg, 2 mg, 3 mg, etc); MDD 30 mg
Lorazepam 0.5mg PO/IV/SLevery 1 hour as needed
(notify MD before initiating this step)MDD 12 mg
Continue LorazepamEvaluate regularly to taper or
discontinue
Physician/Nurse/Pharmacist consultation
relief no relief
relief
no relief after MDD Haldol
no relief after 24 hours
Excessive physical or mental restlessness. Increased activity that is generally not purposeful and associated with anxiety.
Depending on appropriateness, evaluate for reversible causes, including delirium and treat the underlying etiology if possible.Symptom control may begin concurrent with diagnositic work up.
Nonpharmacological interventions: reorientation, maintaining sleep wake scheduleAvoid restraints, minimize immobilizing treatments, maintain communication, med reconciliation
Consult MD:atypical antipsychotic medsstarting doses for delirium
Olanzapine 2.5mg q12hrsRisperidone 0.25mg q12hrsQuetiapine 12.5mg q12hrs
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 5
Alternative Route for Opioid Administration
If patient is unable to take PO analgesicAND
IV access is not available
Example: 360 mg of PO MSO4every day divided by 3 = 120
divided by 24 hrs = basal rate of 5 mg/hr IV MsO4
PCA dose would be 2.5 mg q 6 minBolus = 3 times basal dose = 15 mg
q 1hr
Convert 24-hour opioidrequirement of continuous
infusion of Basal Opioid via PCA pump. May add PCA dose of
atleast 50% of basal rate every 6 min w/ bolus 3 times basal rate
of every1 hrConsult physician for orders
Convert to Fentanyl patch using equianalgesic coversion card,
continue to give Fentanylsublingual at dose of 25 mcg
every ½ hour prn(Note: no benefit from patch for
8-14 hours)
Convert to subcutaneous infusion of PCA using 27 gauge needle (PCA dose remains the same, change lock out to every 15 min). Infusion volume not to
exceed 2 ml/hr.Remember can call pharmacy for assistance in how to order
SQ PCA.
Convert to rectal, vaginal or stoma route for long acting opioid (same dose) using
Fentanyl injection sublingual 25 mcg every 30 min prn.
Can give Roxanol(morphine20mg/ml) and it can be given to
patients that aren’t awake. Document patient ability to
maintain internally.
OPTIONS
May also place subcutaneous needle for use if only intermittent opioids required, convert PO dose to parenteral dose using equianalgesic
conversion card. Continue prn schedule.
** Physicians NOTE: Please consider incomplete cross tolerance in your conversions.
If IV access is no longer availableAND
Patient is able to take PO medications, select appropriate long and short acting opioids and
convert dosage requirements using equianalgesicconversion card
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 6
Anorexia
Appetite SuppressionIF BOTHERSOME TO PATIENT
Continue megestrol at current dose
Trial of megestrol acetate (Megace)400 mg liquid PO daily
Reassess at 1 week for efficacy
Trial of Ritalin 5mg daily at 8am and noon(see effect in 2-3 days)
Continue RitalinReassess at regular intervals
relief no relief
relief
A loss of appetite with noted weight loss which is bothersome to the patient.
Supportive counseling for patient and family:anorexia as a natural symptom of disease, validation of normalcy, dietary and nutritionalchanges and counseling
Prednisone 20mg daily (considered most useful if estimatedprognosis less than 6 weeks)
HIV Patients: Dronabinolstarting dose 2.5mg bid MDD 20mg daily Trial of Ritalin 10mg bid
8am and noon
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 7
Anuria
Catheterize for residual urine or perform bedside bladder scan if available
Less than 250 mlsOver 250 mls
Leave catheter in place,Consult MD
Evaluate volume statusConsult MD/RN/Rx
Re-asses catheter need periodicallyIf catheter becomes plugged irrigate with
normal saline prn
Minimal to no urine output.
Review medications: anticholinergic, opioids ascause
BPH: initiate treatmentas appropriate
Anuria can be part of dying process, enact algorithm if unexpected or patient symptomatic, eg pain, agitation.
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 8
Bladder Spasms Treatment
Obtain urinalysis and culture of clean catch
urine
If indwelling catheter is present would do this
first
Negative urinalysis
Positive urinalysisContact MD
Anticipate TMP/SMX
Assess catheter function; irrigate gently with NS
Consider replacing if catheter present
greater than 5 days
Oxybutynin 5 mg PO TID x 48 hours-
MDD 20 mg. If PO difficult, available in
patch 3.9mg/day twice a week
Start TMP/SMX DS PO twice/day; if sulfa allergic, cipro 250mg
PO bidDuration determined
by MD
No further intervention is
needed
Oxybutynin 5 mg TID x 48 hours
MDD 20 mgOR
Scopolamine 0.4mg IV or sub
cutaneously every 4 hours prn
Continue Oxybutynin
MD/RN/Rx consult Beladonna & Opiumsuppository ½-1 PR every day-twice/day
ORScopolamine patch
every 72 hoursOR
scopolamine 0.4mg IV every 4 hours prn
Promote increased fluid intake as appropriate
Oxybutynin 5 mg PO TID x 48 hours
MDD 20 mg
An intermittent cramping sensation of the bladder resulting in discomfort and/or pain.
Treat pain with prnanalgesic while analysing cause
Alternative to oxybutynins:Tolterodine
Newer agents: solifenacin,Trospium, darifenacin
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 9Bowel treatment – stepped care program
Stool softener and/or gentle laxativeDocusate 100 mg twice/day (taking no
opioids)Senokot 1 tab twice/day (taking opioids)
If no bowel movement for 48 hour period add one of these:
Milk of magnesia concentrate 10 ml poevery day
ORBisacodyl 10 mg PO/PR every day if po
not tolerated or refused
If no bowel movement in next 12 hours, perform rectal exam
to rule out impaction
If not impacted, Magnesium citrate 8 oz
ORFleets enema
Soften with glycerin suppository then manually disimpact
Follow up with a tap water enema until clear and increase
intensity of bowel regimen
Increase the prophylactic regimen
Consult MD/RN/Rx
If impacted, Fleets enema
Increase the prophylactic regimen
Consult MD/RN/Rx
Treatment to alleviate hard stools and/or constipation associated with opioid administration.
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 10
Candidiasis – Oral
Nystatin susp 400,000-600,000 swish and swallow four times/day; hold in
mouth 2-5 minutesOR
Clotrimazole troche 10 mg five times a day
Improved after 48 hours
Continue 7 days or per MD orders
Not improved and patient using appropriately, or not able
to swallow
Fluconazole 200 mg Loading Dose then 100 mg every day x 14 days.
Consider MD/RN/Rx consult.
Whitish patches on the inner oral cavity, tongue or throat, which may or may not cause discomfort.
Remember someone who is immunocompromised may need to get fluconazole from the beginning.
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 11
Candidiasis – Perineal
Clotrimazole lotion 1% applied twice/day
Improved after 48 hours
Continue clotrimazole7-14 days
No improvement after 48 hours
Fluconazole 200 mg one time dose. Consider MD/RN/Rx consult.
Reddened areas between skin folds in the genital area, which may or may not cause discomfort.
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 12
DyspneaComplete respiratory assessmentIf oxygen sats <90% give oxygen
2L/min.Check hemoglobin and transfuse if
consistent with care goals established on signout.
Complains of dyspnea
Bronchospasm with audible wheeze
If mild CHF(crackles on
exam), with respiratory distress
Furosemide 40 mg PO/IV for one dose
Monitor for improvement. Consider MD consult
For end stage, consider fentanyl nebulizer 25 mcg every 2 hours prn with 2.5
ml of NS
Trial of oxygen 2 liters/min
Reassess every 2 hours
If no relief, Consider Morphine 10 mg PO every
2 hours prn or 3 mg subcutaneous or IV; monitor respirations
Fentanyl nebulizer 25 mcg in 2.5 ml of NS every 2 hours prn
If no relief, lorazepam 0.5 mg every 4 hours prn.
Monitor respirations
If relief, continue lorazepam prn
MDD 10 mg/day
Albuterol 2 inhalations every 4 hours prn or 3ml
nebulized every 2 hours prn
If no relief, add oxygen 2 liters/min and ipatropium 1-2 inhalations every 4-6 hours
prn or 2.5 ml nebulized every 4 hours prn
If relief, continue
If improvement, continue
If no relief, add fentanylnebulizer 25 mcg in 2.5 ml NS
every 2 hours prn.Consider MD/RN/Rx consult.
Consider adding oxygen 2 liters/min
The sensation of air hunger. May be exhibited by gasping, accessory muscle involvement in
breathing, tachypnea, discomfort.
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 13
Fever
Symptomatic Fever or RigorsRefer to signout to see goals of care.
Workup needed?
Source of infection is suspected by history or exam
Treat symptomatically, especially end stage disease
MD/RN/Rx consult for workup and possible antibiotic therapy
Acetaminophen 650 mg PO/PR every 4 hours scheduled x 24 hours if symptomatic or temp > 101 PO
Reassess after 24 hours
If no relief, try Ibuprofen 400 mg or ketorolac IV (15 mg)every 6 hrs x 24 hrs
If no relief, consider MD/RN/Rx consult
yes no
A temperature of over 101.4 (orally), 100.4 (axillary), or 100.4 (for patients with known neutropenia.
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 14
Hiccough
Baclofen 5mg poevery 6 hours prn,
can increase to 10mg every 6hrs if
CrCl >30
Can continue baclofen. Haloperidol 2 mg PO/Subcutaneous/IV
Maintenance 2 mg PO three times/day
Continue as neededConsider scheduling
Metoclopramide 10 mg PO/IV every 6 hours prn
Maintenance 10-20 mg po 4 times/day
Continue as needed
If no relief, consider anesthesia consult for block
Continue as needed
No effect
EffectIf no effect or unable to take PO
Effect
A spasmodic intermittent closure of the glottis following lowering of the diaphragm causing a short, sharp, inspiratory cough.
Nonpharmological treatment:Holding breath, mild irritation of nasopharynxValsalva, sipping liquids slowly, 5th vertebrae rubbing
If GERD: maalox 30ml prn, canStart PPI on formularyEg: omeprazole 40mg daily
Gabapentin 300mg tid
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 15
Mucositis(without obvious infection)
Sodium bicarbonate rinsesOR
1:1 Isotonic saline/sodium bicarbonate rinses every 2 hours while awake
If relief, continue rinses as needed. Reassess in 7 days.
If no relief, start trivalent mouth wash (Benadryl, maalox, lidocaine mixture)5 ml
swish/spit every hourOR
swish/swallow every 4 hours
Consider other analgesic interventions such as PCA, viscous lidocaine, topical cocaine. Physician/RN/Rx
consult.
No relief after 24 hours
Inflammation of the mucus membranes. Generally causes pain in the oral cavity and throat and exhibited by excessive drooling, spitting and mucus production.
Evaluate for and treat thrush if present
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 16
Pruritus
Establish probable cause:
Consider medications, high bilirubin, skin irritants
Hydroxyzine 10 mg every 6 hours PO prn
If obstructive jaundice-cholestyramine 4gm PO every day.
Contact physician for order.
Hysricortisone/Pramoxine foam 4 times/day prn
ORDiphenhydramine 25 mg PO/IV
every 6 hours
Improved after 24 hours, continue prn
No improvement after 48 hours
Increase cholestyramine to 4gm PO twice/day
MD/RN/Rx consult
Severe itching.
If opioid induced, contact physician, consider narcan infusion
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 17
Secretions
Assess saliva
Diminished saliva (xerostomia)
Increased secretions without trach(Note: with trach evaluate risk of excessively drying up secretions)
Thick secretions
Guafenesin 200 mg PO every 4 hours prn
Increase fluid intakeEncourage oral fluid intake and good oral care
Use artificial saliva
Suck on sugarless candy, chew
sugarless gum
If history of radiation to head/neck Pilocarpine 4%
opthalmic drops 5 drops PO three times/day
If disturbing to pt/family, consider a trial of scopolamine patch every 72
hours and scopolamine 0.4 mg subcutaneous/IV now and every 4
hours prn
No reliefIf relief, continue treatment
Add a second scopolamine patch every 72 hoursOR
Increase scopolamine to 0.6mg subcutaneous/IVevery 4 hours prn
If no relief, MD/RN consult
Oral or airway lubrication. May be noted by excessive, noisy respirations
If patient unconscious, consider suction
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 18
Seizures – Acute Management
Seizure
Lorazepam 2 mg IV/Sublingual/Subcutaneous statNotify physician
May repeat in 15 min prnMAXIMUM 8 mg
Is it appropriate to escalate care for this patient?
Notify family, consider chronic suppression with lorazepam
Notify physician for appropriate work-up, monitoring and medication load for chronic suppression therapy
Yes No
Sudden, non-purposeful, rhythmic movement of any part of the body or facial muscles lasting from less to a minute to more that several minutes.
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 19
Sleep Disturbance(consider etiology, treat cause)
Consider cause including pain, anxiety, agitation, caffeine, medications
Zolpidem 5 mg PO at bedtime, may repeat in one hour
If sleep loss related depression, Consult physician
If relief, continue as needed
If no relief after 2 nights, notify physicianConsider a trial of temazepam 15 mg PO qhs
Use with caution in > 60 yr old
If relief, continue as needed
An inability to fall asleep and or stay asleep causing discomfort or fatigue.
Control environmental factors: minimize nighttime interruptions, lights, television, late meals, caffeine encourage daytime OOB, and lights
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 20
Wound Odor
Use room deodorizer
Apply absorptive dressing with wound cover using:•Calcium alginate•Gauze apcking•4x4s or kerlix roll gauze with NS•Foam dressing, or•Baby diapers for heavy drainage
Apply non-adherent (oil emulsion) gauze as first layer on wounds that are dry, when dressings stick,
or bleeding is a factor
Cleanse with normal saline or wound cleanser
Consider topical metrogel (in a heavily draining wound this may increase drainage and not help odor)
Consult Wound Care TeamContinue
Lightly spray outer dressing with Enzymatic Rain with each change
A strong, noticeable, offensive smell emanating from a wound.
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 21Algorithm Evidence-Based References
• Agitation– Jackson, KC, Lipman, AG. Drug therapy for delirium in terminally ill patients. In: The Cochrane Library, Issue 2, Chichester, UK:
John Wiley Sons, 2004.– Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, Corbera K, Raymond S, Lund S, Jacobson P. A double-
blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J.Psych1996 ;153:231-7.
– Stahl, S. Essential Psychopharmacology: Neuroscientific Basis and Practical Applications 2nd ed. Cambridge University Press 2000.
– Pasacreta, J., Minarik, P., & Nield-Anderson, L. (2006). Anxiety and depression. In B. R. Ferrell, & N. Coyle. (Eds.), Textbook of palliative nursing (2nd ed., pp. 375-400). New York, NY: Oxford University Press.
• Alternative Route for Opioid Administration– Bruera E, Brenneis C, Michaud M, et al. Use of the subcutaneous route for the administration of narcotics in patients with cancer
pain. Cancer 1988; 62: 407-411. – Principles of analgesic use in the treatment of acute pain and cancer pain. American Pain Society, 5 th Edition, 2003
www.ampainsoc.org– Pereira J et al. Equianalgesic dose rations for opioids: a critical review and proposals for long-term dosing. J Pain Sym Manage
2001;22:672-687.– Gourlay GK. Treatment of cancer pain with transdermal fentanyl. The Lancet Oncology 2001; 2:165-172.
• Anorexia– Jatoi A, Windschitl HE, et al. Dronabinol Versus Megestrol Acetate Versus Combination Therapy for Cancer-Associated Anorexia:
A North Central Cancer Treatment Group Study. Journal of Clinical Oncology, Volume 20, Number 2, 2002; 567-573.– Inui, A., Cancer Anorexia-Cachexia Syndrome: Current issues in research and management, CA Cancer J Clin 2002; 52: 72-91.– Jatoi, A. On appetite and its loss, Classic Papers, Supplement to JCO, Vol 21, No 9 (May 1), 2003: pp 79s-81s.– Bistrian, B. (1999). Clinical trials for the treatment of secondary wasting and cachexia. Journal of Nutrition, 129(1S Suppl), 290 S-
294 S – Fainsinger, R. L., & Periera, J. (2004). Clinical assessment and decision-making in cachexia and anorexia. In D. Doyle, G.W.C.
Hanks, N. Cherney, & K. Calman. Oxford textbook of palliative medicine (3rd ed., pp. 533-560). Oxford, UK: Oxford University Press
• Anuria– Cravens (2000) Am Fam Physician 61(2): 369-76– Walsh (1998) Campbell's Urology, Saunders, p. 159-62
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 22Algorithm Evidence-Based References
• Bladder Spasms Treatment– Herbison, P, Hay-Smith, J, Ellis, G, Moore, K. Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive
bladder: systematic review. BMJ 2003; 326:841.– Nicolle, LE, Bradley, S, Colgan, R, et al. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic
bacteriuria in adults. Clin Infect Dis 2005; 40:643.– Howe, RA, Spencer, RC. Cotrimoxazole. Rationale for re-examining its indications for use. Drug Saf 1996; 14:213.
• Bowel Treatment – stepped care program– Klaschik E, Nauck F, Ostgathe C. Constipation--modern laxative therapy. Support Care Cancer. 2003;11(11):679-685. Epub 2003 Sep 2020.– Mancini I, Bruera E. Constipation in advanced cancer patients. Support Care Cancer. 1998; 6(4):356-364.– Locke, GR III, Pemberton, JH, Phillips, SF. AGA technical review on constipation. Gastroenterology 2000; 119:1766.
• Candidiasis – Oral– Pappas PG, Rex JH, Sobel JD, et al. Guidelines for treatment of candidiasis. Clin Infect Dis 2004; 38:161-89.– Sweeney MP, Bagg J. The mouth and palliative care. Am J Hosp & Pall Care 2000; 17(2):118-124.
• Candidiasis – Perineal– Sobel JD, Brooker D, Stein GE, Thomason JL, Wermeling DP, Bradley B, Weinstein L. Single oral dose fluconazole compared with conventional
clotrimazole topical therapy of Candida vaginitis. Fluconazole Vaginitis Study Group. Am J Obstet Gynecol. 1995 Apr;172(4 Pt 1):1263-8. – National guideline for the management of vulvovaginal candidiasis. Clinical Effectiveness Group (Association of Genitourinary Medicine and the
Medical Society for the Study of Venereal Diseases). Sex Transm Infect 1999; 75 Suppl 1:S19.– Rex, JH, Walsh, TJ, Sobel, JD, et al. Practice guidelines for treatment of candidiasis. Clin Infect Dis 2000; 30:662.
• Dyspnea– Bruera E, Sweeny C and Ripamonti C. Dyspnea in patients with advanced cancer. In: Principles and Practice of Palliative Care and Supportive
Oncology. 2 nd Ed Berger A, Portenoy R and Weissman DE (eds). Lippincott-Raven, 2002. – Chan KS et al. Palliative Medicine in malignant respiratory diseases. In Oxford Textbook of Palliative Medicine 3 rd Ed. Doyle D, Hanks G,
Cherney N and Calman N. Oxford, 2005 – Fohr SA. The double effect of pain medication: separating myth from reality. J Pall Med 1998; 1:315-328.– Coyne, P. J., Lyne, M.E., & Watson, A. C. (2002). Symptom management in people with AIDS. American Journal of Nursing, 102(9), 48-56. – Coyne, P., J., Viswanathan, R., and Smith, T., "Nebulized Fentanyl Citrate Improves Patients Perception of Breathing, Respiratory Rate, and
Oxygen Saturation in Dyspnea." Journal of Pain and Symptom Management. February, 23 (2), 2002, pp. 157-160. • Fever
– Zell JA, Chang JC. Neoplastic fever: a neglected paraneoplastic syndrome. Support Care Cancer. 2005 Nov;13(11):863-4. – Oh DY, Kim JH, Kim DW, Im SA, Kim TY, Heo DS, Bang YJ, Kim NK Antibiotic use during the last days of life in cancer patients. Eur J Cancer
Care (Engl). 2006 Mar;15(1):74-9.– Boulant JA: Thermoregulation. In: Machowiak PA, ed.: Fever: Basic Mechanisms and Management. New York, NY: Raven Press, 1991, pp 1-22– Oken, M.M., Creech, R.H., Tormey, D.C., Horton, J., Davis, T.E., McFadden, E.T., Carbone, P.P.: Toxicity And Response Criteria The Eastern
Cooperative Oncology Group. Am J Clin Oncol 5:649-655, 1982.– Young LS: Fever and septicemia. In: Rubin RH, Young LS, eds.: Clinical Approach to Infection in the Compromised Host. 2nd ed. New York,
NY: Plenum Medical, 1988, pp 75-114– Zhukovsky DS: Fever and sweats in the patient with advanced cancer. Hematol Oncol Clin North Am 16 (3): 579-88, viii, 2002.
• Hiccough– Kolodzik PW, Eilers, MA: Hiccups (singultus): Review and approach to management. Ann Emerg Med 1991; 20:565-573.– Rousseau, P. Hiccups. Southern Med J 1995; 2: 175-181. – Lewis J. Hiccups: Causes and cures. J Clin Gastro 1985; 7:539-552.
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.
April 2010 23Algorithm Evidence-Based References
• Mucositis– Dodd MJ, et al. Radiation-induced mucositis: a randomized clinical trial of micronized sucralfate versus salt & soda mouthwashes. Cancer
Invest. 2003;21(1):21-33. – Shih A, Miaskowski C, Dodd MJ, Stotts NA, MacPhail L. A research review of the current treatments for radiation-induced oral mucositis in
patients with head and neck cancer. Oncol Nurs Forum. 2002 Aug;29(7):1063-80. Links– Berger AM and Kilroy TJ. Oral Complications. in DeVita V et al (eds) Cancer: Principles and Practices of Oncology. 6 th edition. Lippincott
Williams & Wilkins. 2001.– Rubenstein, EB, Peterson, DE, Schubert, M, et al. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral
and gastrointestinal mucositis. Cancer 2004; 100: 2026.– Epstein, JB, Schubert, MM. Oropharyngeal mucositis in cancer therapy. Review of pathogenesis, diagnosis, and management. Oncology
(Huntingt) 2003; 17:1767.• Pruritus
– Alan B. Fleisher, Jr and Jason R. Michaels. Pruritus. In: Principles & Practice of supportive Oncology. Eds: Ann Berger, Russell K. Portenoy, David E. Weissman. Lippincott-Raven Publishers Philadelphia 1998; 245-250.
– Krajnik M and Zylicz. Understanding pruritis in systemic disease. J Pain Symp Manage 2001; 21:151-168.• Secretions
– Wilders H, Menten J. Death rattle: prevalence, prevention and treatment. J Pain Symptom Manage 2002; 23:310-317.– Cooke, C, Ahmedzai, S, Mayberry, J. Xerostomia--a review. Palliat Med 1996; 10:284.– Richardson, PS, Phipps, RJ. The anatomy, physiology, pharmacology and pathology of tracheobronchial mucus secretion and the use of
expectorant drugs in human disease. Pharmacol Ther [B] 1978; 3:441.• Seizures – Acute Management
– DroneyJ, Hall E, Status Epilepticus in a Hospice Inpatient Setting. Journal of Pain and Symptom Management Vol36 No 1 July 2008– Cereghino, J. Rectal Diazepam for threayment of Acute Repetitive Seizures in Adults. Archives of Neurology Vol 159 Decemver 2002– Treiman, DM. Pharmacokinetics and clinical use of benzodiazepines in the management of status epilepticus. Epilepsia 1989; 30(suppl 2):s4.– Chapman, MG, Smith, M, Hirsch, NP. Status epilepticus. Anaesthesia 2001; 56:648.
• Sleep Disturbance– Carlos H. Schenck, Mark W. Mahowald, and Robert L. Sack.Assessment and Management of Insomnia JAMA 2003 289: 2475-2479.
• Wound Odor– Paul Walker. The pathophysiology and management of pressure ulcers. In: Topics in Palliative Care, Volume 3. Eds. Russell K. Portenoy and
Eduardo Bruera. Oxford University Press 1998. Pp 253-270.– Grocott P. The palliative management of fungating malignant wounds. J Wound Care. 2000; 9 (1):4-9. – Newman V, Allwood M, Oakes RA. The use of metronidazole gel to control the smell of malodorous lesions. Palliat Med. 1989; 3: 303-305.– Bates-Jensen, B.M. (2006). Skin disorders: Pressure ulcers – assessment and management. In B.R. Ferrell, & N. Coyle (Eds.), Textbook of
palliative nursing (2nd ed., pp. 301-328.). New York, NY: Oxford University Press. – Bates-Jensen B.M., Seaman, S. & Early, L. (2006). Skin disorders: Tumor necrosis, fistules, and stoma. In B.R. Ferrell, & N. Coyle (Eds.),
Textbook of palliative nursing (2nd ed., pp. 329-344.). New York, NY: Oxford University Press– Grocott, P., & Dealey, C. (2004). Symptom management: Nursing aspects. In D. Doyle, G. Hanks, N. Cherney, & K. Calman (Eds.) Oxford
textbook of palliative medicine (3rd ed., pp. 628-640). Oxford, UK: Oxford University Press.
Palliative Care Algorithms These are to be used as general guidelines. They do not replace the traditional nurse-doctor-patient relationship. Please review carefully before using. Please note the PO route is always the initial route when possible.