paper discussion - fmge solutions...dr.deepak marwah 1. 15-year-old boy is having cirrhosis of liver...
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PATHOLOGY– 1T&DJUNE2020PaperDiscussionDR. DEEPAKMARWAH
1.15-year-oldboyishavingcirrhosisofliverleadingtorecurrentascites.Hehasdevelopedbehaviouralproblems,dystonia,rigidityandKFringisnotedintheeyesofpatient.Whichstainwillbeusedtodemonstratecoppertoxicity?a.Hemosiderinb.Sudanblackc.Vonkossad.Rubeanicacid
2.Cholesterolembolismoccursdueto?a.Traumaleadingtofractureoflongbonesb.Worminfestationinlymphaticsblockingchylec.Endothelialcellinjuryd.Fissureofatheroscleroticplaque
3.Donovanbodiesareseenin?a.LeishmaniaDonovanib.Granulomainguinalec.LymphomaHodgkinsd.LymphomaNon- Hodgkins
4.WhichstainisusedforGbandinginchromosomestaining?a.Congoredb.ThioflavinTc.Giemsad.Quinacrine
5.Corallinethrombusisseenin?a.Arterialthrombosisb.Venousthrombosisc.Postmortemthrombosisd.Superficialthrombophlebitis
6.Whichofthefollowingcellsismostresistanttoischemiccells?a.Cardiacmyocyteb.Neuronc.Nephrond.Fibroblast
7.Brownindurationoflungsisseenin?a.Rightheartfailureb.Leftheartfailurec.Anthracosisd.Berylliosis
8.WhichofthefollowingisincorrectaboutAmyloidosis?a.Xraycrystallographyshowsabetacrosspleatedsheathb.Nephroticrangeproteinuriac.Sagospleenshowstapiocalikegranulesd.ApplegreenbirefringenceonlightmicroscopywithSchiff’sreagent
9.CorrectaboutMalloryHyalinebodies?a.Aggregatesofintermediatecytokeratinfilamentsincytoplasmofhepatocytesb.AggregatesofCytokeratinfilamentsinnucleusofhepatocytesc.AggregatesofintermediatecytokeratinfilamentsincytoplasmofKupffercellsd.AggregatesofCytokeratinfilamentsinnucleusofKupffercells
10.CorrectaboutItocellinliver?a.Responsibleforphagocytosisb.StorageofvitaminAc.Foamymacrophageinfattyliverd.Linesintrahepaticbileducts
11.Extrinsicpathwayofclottinginvolvesa.FactorVb.Factor8c.Caspase8d.Caspase9
12.Stellategranulomaisseenduetoinfectionwithwhichofthefollowing?a.Nocardiab.Treponemapertenuec.BartonellaHenslaed.Actinomyces
13.Michealis gutman bodiesareseenin:a.Erthyroplakiab.Leukoplakiac.Malakoplakiad.Reyesyndrome
14.Namethefixativeusedinroutinehistopathology?a.Glutaraldehydeb.Neutralbufferedformalinc.Hematoxylin eosinstaind.Toluidinebluestain
15.Asteroidbodiesareseenin?a.Silicosisb.Anthracosisc.Sarcoidosisd.Coalworkers’pneumoconiosis
16.Globi arefoundin?a.TBb.Leprosyc.Yawsd.Infectiousmononucleosis
17.WhatisthefunctionofWiebel palade bodies?a.ProductionofVonWilebrand factorb.Productionofclottingfactorsbyhepatocytesc.Productionofbilebyintrahepaticcholangiocytesd.ProductionofclottingfactorbyStellatecells
18.A20-year-oldboyssaysthatheisverythinandhasbeenlosingweight.Hehasbulkyfoul-smellinggreasystoolsaftereverymeal.SmallintestinalmucosalbiopsyshowsPeriodicacidSchiff’reagentpositiveintracellularbacteriavisualizedinlaminapropria.Whatisthediagnosis?a.Pepticulcerdiseaseb.Bacterialovergrowthsyndromec.Whipplediseased.Celiacsprue
19.Prussianbluestainisusedtodemonstratea.Lipofuschinb.Copperc.Irond.Melanin
20.Emperipolesisis?a.Activepenetrationofonecellbyanotherwhichremainsintactb.Programmedcelldeathc.Migrationofleukocytesfromthebloodcirculationtositesofinflammationd.Ingestionofmicrobesintophagosomes
21.Monckebergarteriosclerosisoccursin?a.Tunicaintimab.Tunicamediac.Tunicaadventitiad.Internalelasticlamina
22.Whichofthefollowingisanexampleofmetastaticcalcification?a.PostMIscarb.Cysticercosisc.HypervitaminosisDd.Monckeberg sclerosis
23.Whichofthefollowingdoesnotexhibitphysiologicalatrophy?a.Thymusb.Adrenalc.Gonadsd.Brain
24.Alphafetoproteinisatumourmarkerfor?a.Seminomaoftestisb.Non-seminomatous germcelltumouroftestisc.Trisomy21d.Trisomy18
25.Acuteauto-graftrejectionoccurswithin?a.Fewhoursb.<1monthc.<6monthsd.6-12months
26.Tigered patternofmyocardiumisfoundin?a.Fattychangesinheartb.Hibernatingmyocardiumc.Rheumaticheartdiseased.Hypercoagulablestate
27.Antibodymediatedcellcytotoxicityismediatedby?a.Monocyteb.Giantcellsc.T- suppressorcellsd.NKcell
28.PredominantTcellis?a.CD4+b.CD8+c.NKcellsd.Plasmacell
29.A30-year-oldpatientisadmittedfromruralindia withsymptomsofabdominalpainandfeverforlast2weeks.Hisbloodcultureisdrawnwithcompletebloodcountandintravenousceftriaxonewithofloxacinwasstartedinthepatient.Immediatelythepatientturnedblueandhaddifficultyinbreathing.Whichofthefollowingcellsisresponsibleforthefollowingpresentation?
a.Eosinophilb.Basophilc.Monocyted.Macrophage
30.GeneforHLAislocatedon?a.6pb.6qc.9pd.9q
31.Whichofthefollowingisresponsibleforgraftversushostreaction?a.RecipientBlymphocytesb.DonorT8lymphocytesc.Immunecomplexesd.Recipienteosinophils
32.Geneforbloodgroupislocatedat?a.6pb.6qc.9pd.9q
33.Amyloidaccumulationinbetacellsofpancreasisafeatureof?a.ChronicalcoholisminducedChronicpancreatitisb.Type2diabetesmellitusc.Maturityonsetdiabetesd.Type1diabetesmellitus
34.Microangiopathichaemolyticanemia isseenin?a.Henochscholein purpurab.Haemolyticuraemic syndromec.Hereditaryspherocytosisd.Favism
35.A75year- oldmanhasdevelopedAmnesia,apraxiaandanosoagnosia.Whichofthefollowingwouldbefoundonpostmortem?a.ATTRdepositioninneuronsb.Aβdepositioninter-neuronalc.Aprocalcitonindepositionintra-neuronald.Aβ2 depositioninsynoviumandtendonsheath
36.Contractionofendothelialcellsoccursduetoincreasedvascularpermeability.Whichbloodvesselsareinvolvedinthisleakiness?a.Arteriolesb.Capillariesc.Venulesd.Alloftheabove
37.CD62is?a.P- selectinb.PECAMc.ICAMd.Integrin
38.Fentonreactionoccursinpresenceof?a.Fe++
b.Superoxideradicalc.Myeloperoxidased.Cobalt
39.WhichoftheseisaFeatureofcancercellsis?a.Pleomorphismb.Prominentnucleolic.Aisonucleosisd.Allofthese
40.Retproto-oncogenene leadsto?a.Glioblastomab.Sipple syndromec.Carcinomabreastd.CML
41.MHCantigenisabsentin?a.Neutrophilb.Epithelialcellc.RBCd.Thrombocyte
42.Mostreactivefreeradical?a.Hydrogenperoxideb.Hydroxylfreeradicalc.Peroxidefreeradicald.SuperoxideAnion
43.ABObloodgroupisanexampleof?a.XlinkedInheritanceb.Autosomalrecessivec.MitochondrialInheritanced.Codominance
44.Anticipationisseenin?a.FragileXsyndromeb.Praderwili syndromec.Angelmansyndromed.TaySach disease
45.Virchowcellsareseenin?a.Leprosyb.TBc.Malignancyd.Catscratchdisease
46.Immuno-stainforneuraltumoursa.NSEb.HMB-45c.Epithelialmembraneantigend.GFAP
47.HTLV-1leadsto?a.Tropicalspasticparaparesisb.B-cellALLc.MantleCelllymphomad.Follicularlymphoma
48.Endometriosisisanexampleof?a.Choriostomab.Hamartomac.Desmoplasiad.Anaplasia
49.Mostlethalofthesehemoglobinopathiesis?a.HbH diseaseb.HbBartsc.HbEdiseased.Thalassemiamajor
50.Besttodifferentiatebetweenintravascularandextravascularhemolysis?a.Ferritinb.Hepcidinc.Transferrind.Haptoglobin
51.Mostreliablefeatureofmalignancy?a.Pleomorphiccellsb.Intensebasophiliac.Lossofpolarityd.Breakofbasementmembraneandcelldissemination
52.Mostcommontypeofmetaplasia?a.Columnartosquamousb.Squamoustocolumnarc.Squamoustopseudostratifiedcolumnard.Columnartopseudostratifiedsquamous
53.Calcificationoftunicaintimaisafeatureof?a.Atherosclerosisb.Arteriosclerosisc.Monckeberg arteriosclerosisd.Hyalinearteriosclerosis
54.WhichofthefollowingdoesnotcontributetocellularSenescence?a.Telomereattritionb.Cellcyclearrestc.Activationoftumoursuppressorgenesd.Respiratoryburst
55.Diapedesisismediatedby?a.CD21b.CD30c.CD31d.CD45
56.Executionerphaseofcaspaseismediatedby?a.Caspase3andcaspase6b.Caspase3andcaspase8c.Caspase8andcaspase9d.Caspase8andcaspase10
57.Modeofdeathinreperfusioninjuryis?a.Apoptosisb.Necroptosisc.Pyroptosisd.Autophagy
58.Painismediatedvia?a.Histamineb.Lymphotactinc.Leukotrienesd.Prostaglandin
59.Anticipationisseenin?a.FragileXsyndromeb.Praderwili syndromec.Angelmansyndromed.TaySach disease
60.Largegranularlymphocytesare?a.Dendriticcellsb.Naturalkillercellsc.CytotoxicTlymphocytesd.RegulatoryTlymphocytes
61.MostorganinvolvementinAmyloidosisleadsto?a.Nephroticrangeproteinuriab.Nephriticsyndromec.Restrictivecardiomyopathyd.Seniledementia
62.HighN:Cratioandhyperchromasia isafeatureof?a.Anaplasiab.Metaplasiac.Dysplasiad.Malakoplakia
63.Mostcommoncancerinthedevelopedworldinmenis?a.Prostateb.Lungc.Colorectald.Skin
64.CommonestpresentationofAIDSincaseofcART notbeinginitiated?a.Orophyrangeal candidiasisb.P.Jirovecic.Bacterialpneumoniad.Tuberculosis
65.Whichofthefollowingisnotahypercoagulablestate?a.Antiphospholipidsyndromeb.FactorVleiden mutationc.Nephroticsyndromed.Hepaticfibrosis
66.Trinucleotiderepeatswithlossoffunctionisseenin?a.FragileXsyndromeb.Huntingtondiseasec.Klinefeltersyndromed.Spinocerebellarataxia
67.Virchowrobinspacesarefoundin?a.Brainb.Lymphnodesc.Heartd.Thymus
68.TypeIIHypersensitivityisseenin?a.Serumsicknessb.Arthus phenomenonc.Pathergyphenomenond.Perniciousanaemia
69.WhichchromosomaltranslocationleadstoAcutelymphoblasticLeukemia?a.t(9:22)b.t(8:14)c.Trisomy21d.t(15:17)
70.Consanguinityseenwithpatternofinheritance?a.ARb.ADc.XLRd.XLD
71.Leadingtumourofspleenis?a.MALTomab.GISTc.Lymphomad.Angiosarcoma
72.Whichiscorrectaboutmatchingofcarcinogenicagentwithdevelopmentofaparticularmalignancy?a.Hepatocellularcarcinoma:polycyclicaromatichydrocarbonsb.Stomachcancer:Nitrosaminesc.Lungcancer:AflatoxinBd.Bladdercancer:β-napthylamine
73.Triphenyltetrazolium chlorideisusedtostudydamagetoheartduetoMI.Whichiscorrectaboutthishistochemicalstaining?a.Redbrowncolourtotheinfarcttissueb.Bluecolourtoinfarcttissuec.Failuretouptakestaind.Concentriccirclesofuptake
74.Classicalpathwaybeginswith?a.C3ab.C3bc.C5ad.AgandAbcomplex
75.Allarehighlypremalignantconditionsoforalcavityexcept?a.Chronichyperplasticcandidiasisb.Oralsubmucosalfibrosisc.Orallichenplanusd.Leukoplakia
76.“Owleyeappearanceofcells”notedinlungbiopsyspecimenisindicativeofdiagnosisof?a.Non-Hodgkinlymphomab.MixedcellularitysubtypeofHodgkins lymphomac.Histoplasmosisd.CMVinfection