paradigm shift in models of autism (adapted from martha herbert, phd)

Paradigm Shift in Models of Paradigm Shift in Models of Autism Autism (adapted from Martha Herbert, PhD)(adapted from Martha Herbert, PhD)

SpecificitySpecificity Local changesLocal changes Widespread insults Widespread insults with local with local vulnerabilitiesvulnerabilities

LocusLocus Brain basedBrain based SystemicSystemic

CauseCause GeneticsGenetics Genetic Genetic susceptibilities, susceptibilities, environmental environmental insultsinsults

TimingTiming PrenatalPrenatal Triggers affecting Triggers affecting developmental developmental stagesstages

PlasticityPlasticity HardwiredHardwired Architectural and Architectural and

Metabolic changesMetabolic changesPrognosisPrognosis IncurableIncurable TreatableTreatable

Four Vicious Four Vicious CyclesCycles

Gut inflammation

Abnormal intestinal permeability

Food sensitivitiesMalabsorption

1

Dysfunctional enzymes

AbnormalMethylationbiochemistry

Increased oxidative

stress

2

Environmentaltoxins

Impaireddetoxification

Increaseddamage from

toxins

4TH1 to TH2

shift

IncreasedAutoimmunityAnd allergy

Chronic viralAnd fungal infections

3

Slide courtesy of Dr. Liz Mumper

There Are 5 MAJOR MECHANISMS With Evolving Biomarkers That Give Us

Strong Clues So We Can Effectively

There Are 5 MAJOR MECHANISMS With Evolving Biomarkers That Give Us

Strong Clues So We Can Effectively

Oxidative Stress

Methylation & Transsulfuration

Toxins & Heavy Metals

Immune System Dysregulation

Gastrointestinal Inflammation

Oxidative Stress

Methylation & Transsulfuration

Toxins & Heavy Metals

Immune System Dysregulation

Gastrointestinal Inflammation

TREAT AUTISM AS A MEDICAL, NOT

PSYCHIATRIC DISORDER!

TREAT AUTISM AS A MEDICAL, NOT

PSYCHIATRIC DISORDER!

Cost to Benefit Comparisons Must Be Considered Relative to Every Family’s Unique Circumstances

Inexpensive Expensive

Limited number of

responses

Global

number of

responses

Examples: MB12, Diets, Epsom salts

Examples: HBOT, Colonoscopy, IVIG

Relative Cost for Treatment

Examples: Epsom salts, Melatonin

Examples: MB12 HBOT, IVIG

Relative “Global” Benefits

BIOMEDICAL TREATMENT PRINCIPLES

Remove or reduce dietary stressorsRemove or reduce environmental stressorsRemove or reduce inflammationImprove nutritional supportImprove damaged biochemistryImprove immune functionImprove detoxification

Philosophy: “Break the Gridlock”

Diet

Supplements

Heal the gut

Treat infections

Early testing (?)

Methyl-B12

Treat allergies

LDN, Actos

Referral for colonoscopy

HBOT

“Chelation”

Philosophy: Test only if it will affect treatment

Anti-viral Tx

Methyl-B12IV

therapies

It’s Time To Talk About What Treatments Use Your

Time And Spend Your Money Most Wisely!

It’s Time To Talk About What Treatments Use Your

Time And Spend Your Money Most Wisely!

Works most of the time

Works some of the time

Works a little bit of the time

It’s Time To Talk About What Treatments Use Your And Spend Your

Most Wisely!


Most Wisely!

50% to 90%Response Rate

Methylcobalamin: SQ

Hyperbaric Oxygen

IV Chelation

Healing the Gut

Diets

Supplements

Other IV Therapies

Methylcobalamin: SQ

Hyperbaric Oxygen

IV Chelation

Healing the Gut

Diets

Supplements

Other IV Therapies

Non-IV chelation

Antivirals

Modified Genomics

IVIG

Glutathione, non-IV

Allergy Treatment

Melatonin

Epsom salt baths, MSM

Non-IV chelation

Antivirals

Modified Genomics

IVIG

Glutathione, non-IV

Allergy Treatment

Melatonin

Epsom salt baths, MSM


Most Wisely!


Most Wisely!

25% to 50%Response Rate

LDN

Actos (PPAR)

Homeopathy

Metallothionein promoter

Secretin

Sauna, e.g. FIR

“Natural chelation”

GABA

L-theanine

DMAE

DMG

LDN

Actos (PPAR)

Homeopathy

Metallothionein promoter

Secretin

Sauna, e.g. FIR

“Natural chelation”

GABA

L-theanine

DMAE

DMG

It’s Time To Talk About What Treatments Use Your And Spend Your Most Wisely!

It’s Time To Talk About What Treatments Use Your And Spend Your Most Wisely!

Vitamin A/Bethanecol

TTFD

Transfer factor

NAET

PANDAS

Chiari malformation

Creatine

ALA & TD-ALA

“Zeolite”

“Liver Life”

“NDF & NDF Plus”

Vitamin A/Bethanecol

TTFD

Transfer factor

NAET

PANDAS

Chiari malformation

Creatine

ALA & TD-ALA

“Zeolite”

“Liver Life”

“NDF & NDF Plus”

5% to 25% Response Rate

• Oxytocin• Spironolactone• Thyroid • Lyme disease• Lowering testosterone• D-penicillamine

chelator• Minocycline• COX inhibitors• Stem cells• “Biofilm”

• Oxytocin• Spironolactone• Thyroid • Lyme disease• Lowering testosterone• D-penicillamine

chelator• Minocycline• COX inhibitors• Stem cells• “Biofilm”

New and Exciting Times

It’s Time To Talk About Treatments That Are New Or Being Tried In Different

Ways That May Have Promise

It’s Time To Talk About Treatments That Are New Or Being Tried In Different

Ways That May Have Promise

Clinicians Are Not Yet

In Agreement About These

Variable Response

Rates

And “Average”

Has No Bearing On

Individuality!

And Methyl-B12

And Methyl-B12

A Good Example Is

Secretin

A Good Example Is

Secretin

Some Children Defy the OddsSome Children Defy the Odds

THF

5,10-CH2-THF

5-CH3-THF

Cystathionine

DMG

SAM

Adenosine CBS

Methylated Product(DNA, RNA, Protein, Neurotransmittors)

SAH

Homocysteine

MSMSR

Glutathione Peroxide

SAHH

B6

B6

B6

Reactive Oxygen Species: Peroxides

Methyl acceptor

Cell membrane

The Methylation and Transsulfuration Pathways Provide the Reduced Glutathione (GSH) to Repair Oxidative Damage.

B12

GST M1

Methyl transferase

Cysteine

Trimethylglycine MTHFR

NULL GSH GSSG

Mg

Zn

Methionine

Slide courtesy of Dr. Jill James and Dr. Jeff Bradstreet

BHMT

TRANSMETHYLATION

TRANSSULFURATION

FOLATE CYCLE

A Power Player

Methyl-B12

A Power Player

Methyl-B12

Speech & LanguageSpeech & Language

Socialization Emotion

Socialization Emotion

Executive Function

Executive Function

CH3CH3

CH3CH3

Vending Machinesof the Mind

Vending Machinesof the Mind

PhospholipidsPhospholipidsGA

(Creatine)GA

(Creatine)

NeurotransmittersNeurotransmitters

The Methyl-B12 Grandfather ClockThe Methyl-B12 Grandfather Clock

Methylation

Pays for education to

“make the brain smart”

Pays for education to

“make the brain smart”

Transsulfuration

Pays the body’s firemen and

garbage collectors to

“keep the body safe, clean, and

comfy”

Pays the body’s firemen and

garbage collectors to

“keep the body safe, clean, and

comfy”

MethionineMethionine

SAMSAM

SAHSAH

HomocysteineHomocysteine

Methyl-B12Methyl-B12

CysteineCysteine

GlutathioneGlutathione

The Methyl-B12

Clock

The Methyl-B12

Clock

The Methylation

Transsulfuration Pathways

The Methylation

Transsulfuration Pathways

(with Methionine Synthase)

(with Methionine Synthase)

The “Car” at the Crossroad

is Homocysteine

The “Car” at the Crossroad

is Homocysteine


SAMSAM

SAHSAHB12B12

CysteineCysteine


And Mr. Methyl B12

“Drives” the Car

And Mr. Methyl B12

“Drives” the Car


CysteineCysteine(Not Adenosyl, Cyano, Hydroxy, or Glutathionyl B12 )(Not Adenosyl, Cyano, Hydroxy, or Glutathionyl B12 )

Homocysteine Traffic Is Directed By Two Enzyme

Traffic Cops


SAMSAM



Cystathionine B-Synthase

HomocysteineHomocysteineHomocysteineHomocysteineMethionine

Synthase

Methyl-B12Methyl-B12SAHSAH


SAMSAM


Free Radicals Runaway Electrons Infections

Free Radicals Runaway Electrons Infections

Hg, Pb Heavy Metals

Toxic Chemicals

Hg, Pb Heavy Metals

Toxic Chemicals

Executive Function Speech & Socialization

Methyl-B12Methyl-B12SAHSAH

Methionine

SAM

SAH

MTase

SAHH

Homocysteine

B6 CBS

BHMT

Choline

Betaine

Cystathionine

Cysteine

GSH GSSG

Adenosine

THF

MS5,10-CH2THF Cell Methylation

3

1

2

3

Folate Cycle

Methionine Cycle

Transsulfuration Pathway

Methylation Potential(SAM/SAH)

Antioxidant Potential GSH/GSSH

5-CH3

THF

MTHFR

1 2B12

FOLIC (“FOLIAGE”) ACID CYCLE

B6

5-CH3

THF

THF

MS5,10-CH2THF

MTHFR

Homocysteine

Methionine

FOLIC (“FOLIAGE”) ACID CYCLE

By using the methyl ticket that was sold by Mr. MTHFR, one can

get on the MT Line and take a train ride to make “brain things”

while “putting out fires” and “cleaning house!”

Methyl ticket

The “brain form” of methionine synthase is criticallydifferent from the “body form” of methionine synthase

CobalaminDomain

5-methyl THF Domain

HCY Domain

CapDomain

SAM Domain

Richard Deth, PhD with JN, MD

Cobalamin(vitamin B12)

CobalaminDomain

5-methyl THF Domain

HCY Domain

CapDomain

IN THE CORTEX

SAM Domain

Methyl-B12 Is The Cobalamin That Works BestWith Methionine

Synthase In The Brain

Richard Deth, PhD with JN, MD

Cobalamin(vitamin B12)

M-B12

Without the Cap or SAM domains, oxidized B12 will readily dissociate and must be continuously replaced by more methyl-B12

Response Rate and Intensity of Responses for Methyl-B12

Response Rate and Intensity of Responses for Methyl-B12

1. Subcutaneous: Range 80% to 94% Global responses out of 135 Average 30-45 or more!

2. Nasal: Range 25% to 60% (most say 25% to 30%) Far less global responsiveness

3. Transdermal: Range 5% to 8% Minimal global responsiveness

4. Oral: Range 3% to 5% Minimal global responsiveness

5. Sublingual: Not used; ineffective6. TMG blocks MB12 effects because

BHMT competes with MS!

1) Angioneogenesis from the addition of O2. 2) Angioneogenesis from the removal of O2.3) Increases in blood flow independent of new

blood vessel formation.4) Decreasing levels of inflammatory

biochemicals.5) Up-regulation of key antioxidant enzymes and

decreasing oxidative stress.6) Increased oxygenation to functioning

mitochondria.7) Increased production of new mitochondria 8) Bypassing functionally impaired hemoglobin

molecules secondary to abnormal porphyrin production.

9) Improvement of the immune system and the autoimmune system.

1) Angioneogenesis from the addition of O2. 2) Angioneogenesis from the removal of O2.3) Increases in blood flow independent of new

blood vessel formation.4) Decreasing levels of inflammatory

biochemicals.5) Up-regulation of key antioxidant enzymes and

decreasing oxidative stress.6) Increased oxygenation to functioning

mitochondria.7) Increased production of new mitochondria 8) Bypassing functionally impaired hemoglobin

molecules secondary to abnormal porphyrin production.

9) Improvement of the immune system and the autoimmune system.

MECHANISMS OF ACTION FOR HBOTMECHANISMS OF ACTION FOR HBOT

10) Decreasing the bacterial and yeast load systemically and in the gastrointestinal system.

11) Decreasing the viral load found systemically and the viral load in the gastrointestinal mucosa.

12) Increases in the production of stem cells in the bone marrow with transfer to the central nervous system.

13) Direct production of stem cells by certain areas in the brain.

14) Increased production and utilization of serotonin.

15) The possibility that oxidation may help rid the body of petrochemicals (theoretical only).

16) The possibility that oxidation may help rid the body of mercury and other heavy metals (theoretical only).

10) Decreasing the bacterial and yeast load systemically and in the gastrointestinal system.

11) Decreasing the viral load found systemically and the viral load in the gastrointestinal mucosa.

12) Increases in the production of stem cells in the bone marrow with transfer to the central nervous system.

13) Direct production of stem cells by certain areas in the brain.

14) Increased production and utilization of serotonin.

15) The possibility that oxidation may help rid the body of petrochemicals (theoretical only).

16) The possibility that oxidation may help rid the body of mercury and other heavy metals (theoretical only).

Ann Neurol. 2005 Jan;57(1):67-81

Cell Density High Cell Density Low

Inflammatory Presence

Sweeten et al., 2003 Am J Psychiatry 160(9):1691-3

Neuroscience Letters 241 (1998) 17–20

~3 ½ X greater than controls!

Inflammatory Presence

Connolly et al., 1999 J Pediatr 134:607-13

Oxidative Stress and HBOTOxidative Stress and HBOT

• At pressures below 2.0 atm, HBOT can decrease oxidative stress by increasing anti-oxidant enzyme levels such as:– Superoxide dismutase (SOD)– Catalase– Glutathione peroxidase– Heme-oxygenase-1

• At pressures above 2.5 atm, HBOT may actually increase oxidative stress

• At pressures below 2.0 atm, HBOT can decrease oxidative stress by increasing anti-oxidant enzyme levels such as:– Superoxide dismutase (SOD)– Catalase– Glutathione peroxidase– Heme-oxygenase-1

• At pressures above 2.5 atm, HBOT may actually increase oxidative stress

Before After Mild HBO

SPECT Scans in a 4 y.o. Autistic Child After 10 Treatments Using 1.3 atm and 24% O2

SPECT Scans in a 4 y.o. Autistic Child After 10 Treatments Using 1.3 atm and 24% O2

Heuser et al., 2002Best Publications; 2002:109-15

1. Activity: more age appropriate activity (in contrast to true hyperactivity).

2. Attentive, more: “S/he’s now just ‘with us’ where before s/he wasn’t”. 3. Awareness: increased in general. 4. Bowel function: better stools, change in frequency, consistency,

character of stool; able to potty train fully or more quickly than before. 5. Conversational language: more free speech; interjects own words

[sounds, babble] as attempts to be part of family or therapy interaction; speech flows more freely; longer sentences at appropriate times.

6. Eye contact: improved, turns to the person who is calling or talking; “curious” about eyes and “the meaning” of other’s eyes; holds eye contact longer.

7. Feelings: more in touch with his/her own feelings; understands others feelings or expressions; has higher highs and lower lows in a more normal way of being.

The Results of >30,000 Hours of HBOT Treatments Using 1.3 and 1.5 ATA

The 20 Most Common Parental Observations

8. Gestures are more appropriate; better use of body language to communicate wants, needs, and desires; requests that you attend to his/her emotional or physical needs.

9. Good days: more, better, or of a different nature and quality than seen by family or reported by school and therapists.

10. Happier: a greater general sense of feeling good about his/her self and life in general; demonstrates an attitude that says, “Something about my life is different and better today.”

11. Hyperactivity: more (true hyperactivity not to be confused with a child being more age appropriately active).

12. Opinions: has his/her own opinions and definitely lets you know what they are more than ever before, e.g. s/he expresses more freely and/or more appropriately his/her likes or dislikes, e.g. “the I don't want to's because I'm happy doing what I'm doing and I have my rights, you know!”, etc.

13. Independent: new level of self-assuredness, self-confidence, attempting to do things on his/her own; “self perceived ‘appropriate’ anger or irritation for you not letting him/her do something he/she feels perfectly capable of now doing on his/her own”.



14. “Presence”: more involved; more “with it”; seems much more attune to what is happening on a day-to-day basis and in the world aound him/her.

15. Requests: makes his/her needs known to family, friends, playmates. 16. Self confidence: now present for the first time or greater than before

treatment; seems proud of himself/herself and his/her accomplishments; wants and/or demands you acknowledge what s/he has done; expects praise and “proudly glows” when it is given.

17. Sentence structure: longer; more complete; more complex; better structured; uses adjectives, adverbs, prepositions, pronouns, etc.

18. Spontaneous speech: more frequently initiates conversation; talks more without prompting or just echoing or repeating.

19. Verbalization or vocalization increasing and/or more appropriate, "babbling" increasing; more sounds being made or attempted.

20. Vocabulary: knows more words ; knows words no one ever taught; you find yourself “surprised” that s/he said such-and-such; vocabulary is used more appropriately.



On average, for each 1000 lb of environmentally released mercury, there was a 43% increase in the rate of special education services and a 61% increase in

the rate of autism.

Potential association between autism rates, environmental mercury other

toxins in TexasPalmer, et al., Health and Place 2006

Jun;12(2):203-9

All Reporting Facilities, All Chemicals TRI-(1987-2002) Map shows 3,683 of 48,205 facilities reporting nationwide

Autism rates

Total toxicity

Largest Mercury Mines

Largest Mercury Mines

Chemicals-TRI

Mercury and autoimmunity: implications for occupational and environmental health.Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):282-92. Silbergeld EK, Silva IA, Nyland JF.Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Mercury (Hg) has long been recognized as a neurotoxicant; however, recent work in animal models has implicated Hg as an immunotoxicant. In particular, Hg has been shown to induce autoimmune disease in susceptible animals with effects including overproduction of specific autoantibodies and pathophysiologic signs of lupus-like disease. and antinucleolar antibodies and a positive interaction between Hg and

malaria. These results suggest a new model for Hg immunotoxicity, as a co-factor in autoimmune disease, increasing the risks and severity of clinical disease in the presence of other triggering events, either genetic or acquired.

• Non-IV chelation• Antivirals• Modified Genomics• IVIG• Glutathione, non-IV• Allergy Treatment• Melatonin• Epsom salt baths, MSM

• Non-IV chelation• Antivirals• Modified Genomics• IVIG• Glutathione, non-IV• Allergy Treatment• Melatonin• Epsom salt baths, MSM

It’s Time To Get Moving Before Time Runs Out!It’s Time To Get Moving Before Time Runs Out!

• Methylcobalamin: SQ• Hyperbaric Oxygen• IV Chelation• Healing the Gut• Diets• Supplements• Other IV Therapies



• Major Antifungals• Minor Antifungals• Major Antibacterials• Natural Agents• Special Diets• Probiotics• Digestive Enzymes• Major Anti-inflammatories

• Major Antifungals• Minor Antifungals• Major Antibacterials• Natural Agents• Special Diets• Probiotics• Digestive Enzymes• Major Anti-inflammatories

Healing The Gut Is Mandatory For Success!Healing The Gut Is Mandatory For Success!

Autistic Enterocolitis Histopathology is Similar to Crohn’s

Apthous Ulcers

Lymphonodular Hyperplasia

Inflammatory

NormalI.B.D.

Autism

25

20

15

10

5

0

CD3 CD4 CD8

It’s Time To Get Moving Before Time Runs Out!


• Organic F/V (Jim Adams et.al.)

• CFGF (Karen Serousi, Lisa Lewis)

• SCD (Elaine Gotschall)

• Feingold• Elimination/Rotation• Candida (Crook, Truss)

• Low Oxalate (Susan Owens)

• Organic F/V (Jim Adams et.al.)

• CFGF (Karen Serousi, Lisa Lewis)

• SCD (Elaine Gotschall)

• Feingold• Elimination/Rotation• Candida (Crook, Truss)

• Low Oxalate (Susan Owens)



• B6 & magnesium (Dr. Bernie Rimland)

• Cod liver oil• Essential fatty acids• Zinc• Other B vitamins• Other macro & trace

minerals• Amino acids

• B6 & magnesium (Dr. Bernie Rimland)

• Cod liver oil• Essential fatty acids• Zinc• Other B vitamins• Other macro & trace

minerals• Amino acids

Same Amount Of Same Amount Of

The DifferenceThe Difference

Food Water

Nutritional Value!Courtesy of Don Davis, PhD

Courtesy of Don Davis, PhD




• Non-IV chelation• Antivirals (Stan Kurtz)

• Modified Genomics • IVIG• Glutathione, non-IV• Allergy Treatment• Melatonin• Epsom salt baths, MSM

• Non-IV chelation• Antivirals (Stan Kurtz)

• Modified Genomics • IVIG• Glutathione, non-IV• Allergy Treatment• Melatonin• Epsom salt baths, MSM

• Non-IV chelation• Antivirals• Modified Genomics

(C. Schneider, A. Usman et.al.)

• IVIG• Glutathione, non-IV• Allergy Treatment• Melatonin• Epsom salt baths, MSM

• Non-IV chelation• Antivirals• Modified Genomics

(C. Schneider, A. Usman et.al.)

• IVIG• Glutathione, non-IV• Allergy Treatment• Melatonin• Epsom salt baths, MSM



Be careful not to over-interpret SNPs!Be careful not to over-interpret SNPs!

DON’T FORGET THE ON-OFF SWITCH/DETOUR CONCEPT!DON’T FORGET THE ON-OFF SWITCH/DETOUR CONCEPT!

For an enzyme to be “slowed down” is not the same thing as the enzyme “not

working” at all.

For an enzyme to be “slowed down” is not the same thing as the enzyme “not

working” at all.We are dealing in “relative values”,

not absolute manifestations!We are dealing in “relative values”,

not absolute manifestations!

Personal communication with Dr. Gupta: “About 1/3 of the children improve, occasionally

achieving full recovery!”

Personal communication with Dr. Gupta: “About 1/3 of the children improve, occasionally

achieving full recovery!”

J Autism Dev Disord. 1996 Aug;26(4):439-52.

J Autism Dev Disord. 1996 Aug;26(4):439-52.

-10.0%

-5.0%

0.0%

5.0%

10.0%

15.0%

20.0%

25.0%

30.0%

35.0%

40.0%

45.0%

0

2

4

6

8

10

12

Percent Increase

Pollen Count

Neurobehavioral Regression in Children with Autism and ADHD upon Pollen ExposureNeurobehavioral Regression in Children with Autism and ADHD upon Pollen Exposure

This is very uncommon

Allergy Profile

FAP from IML, GPL

This is very common!

Many food reactions but most with low titers

Most often secondary to intestinal permeability

• LDN (McCandless)

• Actos -- PPAR (Boris/Goldblatt)

• Homeopathy• Metallothionein

promoter (Walsh)

• Secretin• Sauna, e.g. FIR• “Natural chelation”




promoter (Walsh)




An opiate antagonist that affects immunomodulation and mood when used in low

doses. There is initial endorphin inhibition followed by a reactive “endorphin rush”

which seems to normalize immune responses.




promoter (Walsh)





promoter (Walsh)




PPAR agonist which downregulates inflammation by decreasing NF-kappa B. It also has a regulatory effect on about 150 “immune regulator” genes.




promoter (Walsh)





promoter (Walsh)




A neuropeptide and GI hormone. How it works in the brain is unknown but in the gut it may stimulate motility and deliver bicarbonate.

• PANDAS (Swedo)

• Chiari malformation (Boris, Goldblatt, Feldstein)

• Creatine (Green)

• ALA & TD-ALA• “Zeolite”• “Liver Life” • “NDF & NDF Plus”• Many, many more

• PANDAS (Swedo)

• Chiari malformation (Boris, Goldblatt, Feldstein)

• Creatine (Green)

• ALA & TD-ALA• “Zeolite”• “Liver Life” • “NDF & NDF Plus”• Many, many more



• Oxytocin (Rossignol, Bradstreet)

• Spironolactone (Rossignol, Bradstreet)

• Thyroid (Cave, Neubrander, et.al.)

• Lyme disease (Kuchera, Freidenfeld)

• Lowering testosterone (Geirs)

• D-penicillamine chelator (Boris/Goldblatt)

• Minocycline (Jyonouchi)

• COX inhibitors (Boris/Goldblatt)

• Singulair (montelukast)

• “Biofilm” (Usman)

• Stem cells (Morales, Neubrander)

• Oxytocin (Rossignol, Bradstreet)

• Spironolactone (Rossignol, Bradstreet)

• Thyroid (Cave, Neubrander, et.al.)










A neuropeptide involved in communication and interpreting social cues that has been found to be low in the brain in several studies of autistic individuals.

• Oxytocin (Rossignol, Bradstreet)• Spironolactone (Rossignol, Bradstreet)• Thyroid (Cave, Neubrander, et.al.)









• Oxytocin (Rossignol, Bradstreet)• Spironolactone (Rossignol, Bradstreet)• Thyroid (Cave, Neubrander, et.al.)









Downregulates MCP-1 which is high in the brain in some children with autism (Vargas, 2005) and also downregulates inflammation in general.


Spironolactone: Safety and TolerabilitySpironolactone: Safety and Tolerability

• Spironolactone is also commonly prescribed as an adjunct in the treatment of precocious puberty.

• In a six year study using spironolactone in 10 boys (ages 2.3 to 5.6 years) with precocious puberty, no serious side-effects were noted despite relatively high doses of spironolactone (average 5.7 mg/kg/day).

• No change in electrolytes were noted.• 50% of aggressive boys had significant

reduction in negative symptoms.

• Spironolactone is also commonly prescribed as an adjunct in the treatment of precocious puberty.

• In a six year study using spironolactone in 10 boys (ages 2.3 to 5.6 years) with precocious puberty, no serious side-effects were noted despite relatively high doses of spironolactone (average 5.7 mg/kg/day).

• No change in electrolytes were noted.• 50% of aggressive boys had significant

reduction in negative symptoms.

J Clin Endocrinol Metab. 1999 Jan;84(1):175-8. J Clin Endocrinol Metab. 1999 Jan;84(1):175-8.

Now’s The Time To Study The Hundreds Of Biomedical Treatments That Have The Potential To Augment All The Other Standard Educational

And Behavioral Treatments That You Are Already Using Because

They Work To Some Degree Most Of The Time!

Now’s The Time To Study The Hundreds Of Biomedical Treatments That Have The Potential To Augment All The Other Standard Educational

And Behavioral Treatments That You Are Already Using Because

They Work To Some Degree Most Of The Time!

You Can Bet On It!You Can Bet On It!

paradigm shift in models of autism (adapted from martha herbert, phd)

Documents

response ratemethylcobalamin

mb12 hbot

environmental stressorsremove

ivigrelative cost

exciting timesits time

dietary stressorsremove

models of autism

epsom saltsexamples