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TRANSCRIPT
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© 2019 Evexia Diagnostics Inc. All Rights Reserved
Dr. Wayne Sodano, DC, DABCI, DACBN, CIHP, BCTNDirector of Clinical Support & Education, Evexia Diagnostics, Inc.
8 PART SERIES
Part 6 of 8Integrative and Functional Medicine Perspective on Laboratory Interpretation – Patterns of Dysfunction
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Integrative and Functional Medicine Perspective on Laboratory Interpretation – Patterns of Dysfunction
In the 1980s Dr. Harry Eidenier and colleagues began their odyssey looking for particular patterns in blood chemistry tests that would enhance the clinician’s laboratory interpretation skills.
Patterns of the observed changes in blood analytes, as it related to a particular conditions, were extracted from the review of over 10,000 case studies.
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The parameters analyzed by the original researchers:
• Electrophoresis
• Atomic absorption spectroscopy
• Hormonal studies
• Standard hematological studies
• Review of the patient history
• Physical examination
• Urinalysis
• Stool analysis
• Hair analysis
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The researchers stated that the patterns should not be considered absolute and are often empirical.
“No diagnostic procedure is absolute, and no lab test should be used as the sole means of making a diagnosis.”
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Lab Test Results and Patterns of Dysfunction
CONDITIONS SUBSTANCES INCREASED SUBSTANCES DECREASED
Acidosis – metabolic Chloride, potassium, anion gap CO2, Calcium
Adrenal HyperfunctionSodium, chloride, aldosterone, plasma and salivary cortisol, DHEA
Potassium
Adrenal Hypofunction Potassium Sodium, chloride, aldosterone, plasma and salivary cortisol, DHEA
Alkalosis - metabolic CO2, BUN Chloride, calcium, potassium
Allergy (Food and Environmental)
Eosinophils, IgE (normal to increased), basophils (normal to increased), total serum globulins, phosphorous, BUN
Total serum globulins
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Conditions SubstancesIncreased SubstancesDecreased
Anemia – Iron Deficiency(Possible need for HCl) TIBC
Iron, ferritin, MCV, MCH, MCHCRBC (normal/decreased)Neutrophils
Anemia B6 deficiency Serum iron (normal or increased)
GGT, ALT, AST, RBC, Hct, MCV, MCH, Reticulocytes (normal/decreased)
Anemia B12/folate
MCV, urinary and serum methylmalonic acidHomocysteine, MCHSerum iron: (normal/increased)LDH isoenzyme #1
Hgb (normal/decreased)Hct (normal/decreased)
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Condition SubstancesIncreased SubstancesDecreased
Arthritis - RA
Uric acid, liver enzymes, ANA, serum calcium, CRP, ESR, immunoglobulins, BUN
Albumin, complement, HDL
Asthma
Eosinophils, alpha 2 globulin, Hct, Hgb, neutrophils, IgE, LDH (1,2,3, and 5)
Lymphocytes
Biliary Insufficiency/StasisCholecytitis/Cholangitis
GGT, ALP,AST/ALT (normal or increased)Serum protein (normal or increased)ESR, neutrophils, basophils, total cholesterol, LDH
Albumin
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Condition SubstancesIncreased Substances Decreased
Biliary Obstruction – Gall Stones
GGT, ALP, total serum bilirubin, ALT, AST, LDH
Alpha-2 globulin
Cancer (potential for neoplasm)
Changes seen in SPE:Increased alpha-1
glycoproteinIncreased alpha-1 globulinIncreased alpha-2 globulin
Albumin < 4.0 with lymphocyte % < 20
Cholesterol
Carpal Tunnel syndrome Magnesium, zinc, B6
COPDPotassium, WBC count,
neutrophilsRBC count, eosinophils
Hct, Hgb, CO2, lymphocytes, alpha-1
antitrypsin
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Condition Substances Increased SubstancesDecreased
Cramps/Muscle Spasms Magnesium
Dehydration Total protein, chloride, Hgb, Hct, BUN, creatinine
Depression/Emotional Stress Cortisol
DiabetesGlucose, triglycerides (usually above cholesterol), HbA1c,
HDL, CO2
Digestive Inflammation(Leaky gut, colitis, IBS,
IBD)
MCV (normal to increased)MCH (normal to increased)
Total protein, albumin, phosphorous, Hct, Hgb
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Conditions SubstancesIncreased SubstancesDecreased
Digestive Inflammation(Gastritis)
Serum/urinary methylmalonic acidHomocysteineGamma globulinBasophilsALP MCV (normal to increased)MCH (normal to increased)
Total protein, albumin, phosphorous, Hct, Hgb, potassium
Emphysema Hct, Hgb, RBC, potassium CO2, alpha-1 globulin, alpha-1 antitrypsin
Gout
Serum uric acid, Liver enzymes in acute phase, serum creatinine WBC count, serum triglycerides, BUN
Phosphorous
Hypertension - essential
ALP, plasma aldosterone, total cholesterol, serum creatinine, potassium, glucose, atrial natriuretic peptide hormone
Serum albumin, magnesium, ionized calcium, ADH
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Condition SubstancesIncreased SubstancesDecreased
Hypochlorhydria MCV > 90, MCH >31.9, BUN
Phosphorous, Total protein, serum calcium and iron (normal to decreased)CO2, ALP
Kidney Dysfunction –chronic renal dysfunction
Albumin, ALP serum amylase, serum calcium, serum creatinine, CRP, urinary micro-albumin, HDL-C, homocysteine, phosphorous, osteoclastin, alpha-1 glycoprotein
WBC count
Kidney Stones BUN, serum creatinine
Molybdenum deficiency Uric acid
Osteoporosis/Osteomalacia ALP, acid phosphatase, urinary hydroxyproline, CRP Vitamin K
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Condition SubstancesIncreased SubstancesDecreased
Pancreatitis
Serum lipase, serum amylase, ALP, ALT, AST, bilirubin, triglycerides, MCV
Calcium
Parasites - intestinal
Eosinophils, IgE, Basophils (normal to increased)Monocytes (normal to increased)
Serum iron, Hgb, and Hct (normal to decreased)
Polycystic Ovarian Syndrome
Free testosterone, androstenedione, DHEA, cortisol, insulin
Estradiol
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Condition SubstancesIncreased Substances Decreased
Prostate Hypertrophy -Benign
Serum creatinine, PSA (PSA is expressed on both normal and neoplastic prostate tissue)
Thiamine DeficiencyAnion GapGlucose (normal to increased)
Hct and Hgb (normal to decreased)
Zinc Deficiency ALP
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Ask the DoctorA FREE service available to all Evexia clients, accessed
via your Evexia Clinician Portal. Dr. Wayne Sodano,
will review test results, clinical conditions, further test recommendations or
answer any other questions you may have via email. In addition our clients have the option of
scheduling either a telephone or video
conference for a fee.
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To learn more about Evexia Diagnostics
www.evexiadiagnostics.com
18 Titus Road / PO Box 1272Washington, CT 06793
(888) 852-2723
Office HoursMonday - Friday, 8am - 8pm ET
Live chat is available at www.evexiadiagnostics.com
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Dr. Wayne L. SodanoDC, DABCI, DACBN, CFMP, CIHP, BCTN
Next lesson: Part 7 of 8 The ”Must Know” advanced laboratory tests
for a successful treatment outcome