partnering to tackle neglected tropical diseases · filariasis polio yellow fever chagas multiplex...
TRANSCRIPT
![Page 1: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/1.jpg)
Partnering to tackle NeglectedTropical Diseases2013 IEEE Global Humanitarian Technology Conference
Tala de los SantosDiagnostics GroupLeader
21 October 2013
![Page 2: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/2.jpg)
NEGLECTED TROPICAL DISEASES
Photo credit: Olivier Asselin
The most important diseases you’ve never heard of
![Page 3: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/3.jpg)
NEGLECTED TROPICAL DISEASES
Dengue
Leprosy
Yaws
Rabies
Trachoma
HAT
ChagasDiseaseSTHBuruliUlcer
OnchocerciasisLeishmaniasisSchistosomiasis
http://www.who.int/neglected_diseases/diseases/en/Photo credits: WHO/TDR, APOC
![Page 4: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/4.jpg)
http://www.who.int/neglected_diseases/diseases/en/Photo credits: WHO/TDR
Disability
Poverty
Disease
Blindness Disfigurement Malnutrition Extreme disability
Social stigmatization Decrease in economic productivity
![Page 5: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/5.jpg)
1 billion people worldwide currentlysuffer from at least one NTD.
An additional 2 billion people are atrisk.
![Page 6: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/6.jpg)
THE LONDON DECLARATION
By 2020:• Eradicate guinea worm• Eliminate lymphatic
filariasis, leprosy,sleeping sickness, andblinding trachoma
• Control schistosomiasis,STH, Chagas disease,visceral leishmaniasis,and onchocerciasis
6
![Page 7: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/7.jpg)
COMMUNITYBASEDINTERVENTIONS
COMMUNITYBASEDINTERVENTIONS
COMMUNITYBASEDINTERVENTIONS
DEVICESDEVICESDEVICES DIAGNOSTICSDIAGNOSTICSDIAGNOSTICS DRUGSDRUGSDRUGS VACCINESVACCINESVACCINES
OUR 5 PLATFORMS7
PATH drives transformative innovation
![Page 8: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/8.jpg)
Full spectrum of technology development and introduction
Slide 8
Scale up/Apply
Introduce/Optimize
Approve/Recommend
Develop/Validate
Research/Design
![Page 9: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/9.jpg)
Task at hand
9
How can we meet the LondonDeclaration goals for 2020?ChallengeChallenge
Build the right coalition fordevelopment and deployment of new
technology.OpportunityOpportunity
Photo credit: www.thequists.com
![Page 10: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/10.jpg)
Page 10
2
3
4
1
Identify endemiccommunities
Develop
Deliver
Achieve publichealth success
Rx
Reducinginterventionfrequency
Monitoring impact
Picture credit: End7 Campaign
![Page 11: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/11.jpg)
Page 11
2
3
4
1
Identify endemiccommunities
Develop
Deliver
Achieve publichealth success
Rx
Reducinginterventionfrequency
Monitoring impact
Picture credit: End7 Campaign
![Page 12: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/12.jpg)
Page 12
2
3
4
1
Identify endemiccommunities
Develop
Deliver
Achieve publichealth success
Rx
Reducinginterventionfrequency
Monitoring impact
Picture credit: End7 Campaign
![Page 13: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/13.jpg)
Page 13
2
3
4
1
Identify endemiccommunities
Develop
Deliver
Achieve publichealth success
Rx
Reducinginterventionfrequency
Monitoring impact
Picture credit: End7 Campaign
![Page 14: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/14.jpg)
CASE STUDY: ONCHOCERCIASIS
![Page 15: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/15.jpg)
Photo credit: John M. Hunter
Nangodi, Northern Ghana1966
![Page 16: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/16.jpg)
Photos courtesy of Tom Nutman, NIAID, NIH
WHO/TDR/Crump
WHO/TDRPage 16
“The river eats your eyes” WHO/TDR/Stammers
WHO/TDR/OCP
![Page 17: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/17.jpg)
1978: Could ivermectin work againstonchocerciasis?
11/1/2013Page 17
Dr. William Campbell
?
![Page 18: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/18.jpg)
1987: Mectizan® will be made available for aslong as needed.
11/1/2013Page 18
Dr. Roy Vagelos
![Page 19: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/19.jpg)
19
37 million infected37 million infected
300,000blind
300,000blind
Second leadinginfectious cause of
blindness
Second leadinginfectious cause of
blindness
180 million atrisk
180 million atrisk
Photo credits (left to right): T. de los Santos, BMGF, Voice of America, Helen Keller International
1987 1993 1995
APOCAfricaAPOCAfrica
OEPAAmericas
OEPAAmericas
MectizanDonationProgram
MectizanDonationProgram
![Page 20: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/20.jpg)
MectizanDonationProgram
Photo credit: Sightsavers, www.mectizan.orgPage 20
140 milliontablets annually
Over 2 billion tablets donated
![Page 21: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/21.jpg)
July 2013: Colombia declares elimination of onchocerciasis
11/1/2013Page 21
![Page 22: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/22.jpg)
22
Endemic communities Drugs
Delivery Partners
(NGO’s)
MectizanDonation Program
DiagnosticsDonors
![Page 23: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/23.jpg)
Challenges of controlling the disease in Africa
Geographic coverage
Human and fly migration
Vector efficiency
Co endemicity with Loaloa infections
Political unrest and postconflict areas
![Page 24: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/24.jpg)
Marching towardelimination
11/1/2013Page 24
When is it safe to stopmass drug
administration?
How to monitor forpossible re emergence
of infection?
![Page 25: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/25.jpg)
Features of the Ov16 Rapid test
• Easy to use and field friendly
• Rapid results (20 minutes)
• Uses finger stick as sample (5 – 30 uL).
• Long read window / end point stability (>4 weeks)
• Robust and stable
• >1 year at 45 C
• >3 weeks at cycling temperatures
• Does not need to be timed with treatment
• Can easily be integrated with other NTD surveillance
efforts
25
![Page 26: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/26.jpg)
What is the Ov16 rapid test?
• It is a serology based rapid test• Detects human IgG4 antibodies to the Onchocerca
volvulus antigen Ov16
Assay Principle:
Human IgG4
GST Ov16
Reporter AbAnti human IgG4
• Detects exposure to infection (antibody)• Does not detect parasites (antigen)
26
![Page 27: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/27.jpg)
Activities and outputs at Concept Phase
• Identification andengagement of keystakeholders
• User needs assessment• Market research• User and Market
Requirements Document• Target Product Profile
• Identification andengagement of keystakeholders
• User needs assessment• Market research• User and Market
Requirements Document• Target Product Profile
Slide 27 CONFIDENTIAL
Scale up/Apply
Introduce/Optimize
Approve/Recommend
Develop/Validate
Research/Design
CONCEPTNeeds ID andAssessments
PLANNINGDiscovery and
Feasibility
R&DDevelopment and
Prototyping
FIELD STUDIESPilot and
Evaluation
INTRODUCTIONIntroduction and
Deployment
SUSTAINIntegration andSustainability
Case Study: River Blindness Project
![Page 28: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/28.jpg)
Activities and outputs at R&D Phase
• Development of workingprototypes
• SOPs• Failure Mode and Effects Analysis• Commercialization Strategy• Partner search
• Development of workingprototypes
• SOPs• Failure Mode and Effects Analysis• Commercialization Strategy• Partner search
Slide 28 CONFIDENTIAL
Scale up/Apply
Introduce/Optimize
Approve/Recommend
Develop/Validate
Research/Design
CONCEPTNeeds ID andAssessments
PLANNINGDiscovery and
Feasibility
R&DDevelopment and
Prototyping
FIELD STUDIESPilot and
Evaluation
INTRODUCTIONIntroduction and
Deployment
SUSTAINIntegration andSustainability
Case Study: River Blindness Project
![Page 29: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/29.jpg)
Prototype Evolution
• Investigated severalform factors
29
1. Closed assembly
2. Open assembly
3. Removed filter
BC: Behind conjugate
OC: On conjugate
NC: on Nitrocellulose
Direction of flow
T C
![Page 30: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/30.jpg)
Activities and outputs at Field Studies Phase
• Evaluation of beta prototypes• Initiation of technology transfer• Production of small scale validation lots• Validated assay performance and SOPs• Executed commercialization agreement
• Evaluation of beta prototypes• Initiation of technology transfer• Production of small scale validation lots• Validated assay performance and SOPs• Executed commercialization agreement
Slide 30 CONFIDENTIAL
Scale up/Apply
Introduce/Optimize
Approve/Recommend
Develop/Validate
Research/Design
CONCEPTNeeds ID andAssessments
PLANNINGDiscovery and
Feasibility
R&DDevelopment and
Prototyping
FIELD STUDIESPilot and
Evaluation
INTRODUCTIONIntroduction and
Deployment
SUSTAINIntegration andSustainability
Case Study: River Blindness Project
![Page 31: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/31.jpg)
PATH Ov16 Prototypes:Field Evaluation in Togo
![Page 32: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/32.jpg)
Current Status
• All field baseddata collectioncompleted
• Completingreference testingin Togo laboratory
• Will begin analysisand integration ofdata in November2013
11/1/2013Page 32
![Page 33: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/33.jpg)
11/1/2013Page 33
prototypes
Field evaluations
Technology transfer
Commercial launch
Operations research
Policy development
Product uptake
![Page 34: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/34.jpg)
Slide 34
OnchocerciasisLymphaticFilariasis
Polio
Yellow Fever
Chagas
Multiplex STDpanel
Infant HIV
TB EQA
TB MODS
Malaria G6PD
NA extractionkit
GestationalDiabetes
Diabetesscreening
InfluenzaNeglected
Tropical Disease
HIV/STD
Malaria
Noncommunicable
TB
Portfolio Key
Clin
ical
Man
agem
ent
Surv
eilla
nce
Enab
ling
tech
nolo
gies
Other
Diagnostics Group Product Portfolio
Slide 34 CONFIDENTIAL
Scale up/Apply
Introduce/Optimize
Approve/Recommend
Develop/Validate
Research/Design
CONCEPTNeeds ID andAssessments
PLANNINGDiscovery and
Feasibility
R&DDevelopment and
Prototyping
FIELD STUDIESPilot and
Evaluation
INTRODUCTIONIntroduction and
Deployment
SUSTAINIntegration andSustainability
DiarrhealDiseases
![Page 35: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/35.jpg)
Onchocerciasis teamTala de los Santos – Project lead
ScientistsGonzalo DomingoAllison GoldenRoger Peck
TechniciansLindsay YokobeEric StevensNicole LaRue
Field AssociatesMelissa ValdezDunia Faulx
CommercializationRalph SchneidemanJeff Wellhausen
AdministrationDan PhillipsAmanda Vilbrandt
Past team members:Ken HawkinsKathy TietjeBecky Barney
CollaboratorsAPOCOEPATask Force for Global HealthNational Institutes of HealthTogo Ministry of HealthTubingen UniversityUniversity of S. FloridaCenters for Disease ControlWashington UniversityStandard DiagnosticsErasmus University
![Page 36: Partnering to tackle Neglected Tropical Diseases · Filariasis Polio Yellow Fever Chagas Multiplex STD panel Infant HIV TB EQA TB MODS Malaria G6PD NA extraction kit Gestational Diabetes](https://reader033.vdocument.in/reader033/viewer/2022041617/5e3c1eb1caccaa4ba53118d8/html5/thumbnails/36.jpg)
Thank you!
Health within reach for everyone
PATH/Gabe Bienczycki36