Patented USP Tromethamine-Disodium Edetate (tris-EDTA)

Dechra Veterinary Products 7015 College BLvd, Suite 525, Overland Park, KS 66211

866-933-2472 | www.dechra-us.comSound

Feature/Function:TrizEDTA helps potentiate chlorhexidine and antibiotics by disrupting the bacterial cell wall by chelating metal ions, making the cell wall more porous.

» Benefit:Antibacterial

Feature/Function:TrizEDTA helps create an environment unfavorable for bacteria to grow.

» Benefit:Alkalinizing

Feature/Function:The only tris on the market that is patented. It uses USP quality ingredients to ensure high quality and efficacious products.

» Benefit:Patented

TM

ConfidenceI believe the TrizEDTA technology in Dechra’s dermatology product line is an important for managing a variety of skin issues especially where gram-negative bacteria is present.

Invitation (neutral)Let’s take a look at some basic information about the TrizEDTA technology in Dechra’s dermatology products…

Qualify: Identify if a Dechra representative has been in recently:

Doctor, have you been introduced to the TrizEDTA technology in Dechra’s dermatology products.

If YES, confirm and discuss benefits

If NO, engage/detail the customer as the primary contact

CHECK-OFF &ECHO NOTES

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It’s the Customer’s Decision … so you can decide whether Dechra’s patented TrizEDTA technology is a solution you’ll consider for your patients presenting signs that you feel would benefit by using a technology where a therapeutic is warranted for both skin and ear conditions.

Dechra Veterinary Products, 7015 College Blvd, Suite 525, Overland Park, KS 66211

866-933-2472 | www.dechra-us.com

TrizEDTA Technology1

• Patented USP Tromethamine-Disodium Edetate (tris-EDTA) • Action against Gram-negative bacteria • Chelates minerals in bacterial cell walls thereby increasing

their susceptibility to active ingredients in topical products • Alkalinizing • Non-ototoxic • Topical use for dogs, cats, and horses

Dechra 24-Hour Veterinary Technical Support(866) 933-2472 | www.dechra-us.com | support@dechra.com

DermatologyPRODUCT GUIDE

Chlorhexidine Gluconate

TrizEDTA Technology1

• Patented USP Tromethamine-Disodium Edetate (tris-EDTA)• Effective against Gram-negative bacteria • Chelates minerals in bacterial cell walls thereby increasing their susceptibility

to active ingredients in topical products• Alkalinizing• Non-ototoxic• Topical use for dogs, cats, and horses

KetoconazoleA synthetic antifungal drug used to prevent and treat fungal skin infections

Patented Acetic & Boric Acid formulation

• Generally used as adjunctive therapy for bacterial skin infections caused by Gram-positive and Gram-negative bacteria1

• Considered to have residual effects and can remain active on skin after rinsing1

• Bacteria do not tend to develop resistance towards chlorhexidine gluconate• Antifungal properties in concentrations greater than 3%

HydrocortisoneProvides anti-pruritic and anti-inflammatory properties

• Cleansing, drying, acidifying, whitening• Degreasing, deodorizing• Balances skin surface pH making it unfavorable for the overgrowth of

fungus/yeast• Ceruminolytic, keratolytic, keratoplastic, and astringent actions2

• Introduction of TrizEDTA into the bacteria’s environment leads to the release of lipopolyscaccharides, proteins, and phospholipids from the cell wall increasing susceptibility to active ingredients.

• TrizEDTA lowers the bacterial minimum inhibitory concentration (MIC) or, how much of an active ingredient is required to inhibit an organism’s growth.

Outer bacterial cell wall membrane comprised of lipopolysaccharides, proteins, and phospholipids

• A synthetic antifungal used to prevent and treat fungal skin infections• Activity against some gram-positive bacteria, including methicillin-sensitive

and -resistant Staphylococci 3

Miconazole

1 Koch, S.N. (2012). Canine and Feline Dermatology Drug Handbook. Ames: Wiley-Blackwell2 Susceptibility of Selected Otitis Externa Pathogens to Individual and Mixtures of Acetic and Boric Acids. Benson CE - 4th Proceedings of AAVD/ACVD meeting, 1998. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania.3 Kirk’s Current Veterinary Therapy XV. John D. Bonagura, David C. Twedt Elsevier Health Sciences, 2013

Dechra Veterinary ProductsDERMATOLOGY RANGE TECHNOLOGIES

CeramidesAid in moisturizing, repairing, and restoring dry, damaged skin

Allergies and the Atopic Patient

1. Allergens Enter the Skin...

5. The pet begins to scratch, lick, chew, etc. to relieve the itchiness. This can lead to secondary infections and other skin issues.

2. ...Triggering the Immune System to Respond

3. Mast cells release histamines and other inflammatory mediators.

4. Skin becomes pruritic (itchy).

Ceramides help restore moisture in the skinand aid in rebuilding the epidermal barrier

• Ceramides play an essential role in the structure and maintenance of the bar-rier function of the skin. Proper barrier function is necessary to prevent water loss and the entrance of allergens.

• Findings suggest that decreased amounts of ceramides in the skin of dogs with atopic dermatitis may be involved in the impaired barrier function of their skin.4

• Formulations containing lipids identical to those in skin and, in particular, some ceramide supplementation may improve skin conditions caused by impaired barrier function.

4 Characterization and quantification of ceramides in the nonlesional skin of canine patients with atopic dermatitis compared with controls. Lisa V. Reiter, Sheila M. F. Torres, Philip W. Wertz, Veterinary Dermatology, Volume 20, Issue 4, pages 260–266, August 2009

GENERAL CLEANSING/ ANTIPRURITIC

ANTIBACTERIAL/ ANTIFUNGAL

ANTIMICROBIAL/ ANTISEBORRHEIC

ANTI-INFECTIVES

Dechra Veterinary Products US and the Dechra D logo are registered trademarks of Dechra Pharmaceuticals PLC.May 2015

Outer bacterial cell wall membrane comprised of lipopolysaccharides, proteins, and phospholipids

Dechra 24-Hour Veterinary Technical Support(866) 933-2472 | www.dechra-us.com | support@dechra.com

DermatologyPRODUCT GUIDE

Chlorhexidine Gluconate

TrizEDTA Technology1

• Patented USP Tromethamine-Disodium Edetate (tris-EDTA)• Effective against Gram-negative bacteria • Chelates minerals in bacterial cell walls thereby increasing their susceptibility

to active ingredients in topical products• Alkalinizing• Non-ototoxic• Topical use for dogs, cats, and horses

KetoconazoleA synthetic antifungal drug used to prevent and treat fungal skin infections

Patented Acetic & Boric Acid formulation

• Generally used as adjunctive therapy for bacterial skin infections caused by Gram-positive and Gram-negative bacteria1

• Considered to have residual effects and can remain active on skin after rinsing1

• Bacteria do not tend to develop resistance towards chlorhexidine gluconate• Antifungal properties in concentrations greater than 3%

HydrocortisoneProvides anti-pruritic and anti-inflammatory properties

• Cleansing, drying, acidifying, whitening• Degreasing, deodorizing• Balances skin surface pH making it unfavorable for the overgrowth of

fungus/yeast• Ceruminolytic, keratolytic, keratoplastic, and astringent actions2

• Introduction of TrizEDTA into the bacteria’s environment leads to the release of lipopolyscaccharides, proteins, and phospholipids from the cell wall increasing susceptibility to active ingredients.

• TrizEDTA lowers the bacterial minimum inhibitory concentration (MIC) or, how much of an active ingredient is required to inhibit an organism’s growth.

Outer bacterial cell wall membrane comprised of lipopolysaccharides, proteins, and phospholipids

• A synthetic antifungal used to prevent and treat fungal skin infections• Activity against some gram-positive bacteria, including methicillin-sensitive

and -resistant Staphylococci 3

Miconazole

1 Koch, S.N. (2012). Canine and Feline Dermatology Drug Handbook. Ames: Wiley-Blackwell2 Susceptibility of Selected Otitis Externa Pathogens to Individual and Mixtures of Acetic and Boric Acids. Benson CE - 4th Proceedings of AAVD/ACVD meeting, 1998. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania.3 Kirk’s Current Veterinary Therapy XV. John D. Bonagura, David C. Twedt Elsevier Health Sciences, 2013

Dechra Veterinary ProductsDERMATOLOGY RANGE TECHNOLOGIES

CeramidesAid in moisturizing, repairing, and restoring dry, damaged skin

Allergies and the Atopic Patient

1. Allergens Enter the Skin...

5. The pet begins to scratch, lick, chew, etc. to relieve the itchiness. This can lead to secondary infections and other skin issues.

2. ...Triggering the Immune System to Respond

3. Mast cells release histamines and other inflammatory mediators.

4. Skin becomes pruritic (itchy).

Ceramides help restore moisture in the skinand aid in rebuilding the epidermal barrier

• Ceramides play an essential role in the structure and maintenance of the bar-rier function of the skin. Proper barrier function is necessary to prevent water loss and the entrance of allergens.

• Findings suggest that decreased amounts of ceramides in the skin of dogs with atopic dermatitis may be involved in the impaired barrier function of their skin.4

• Formulations containing lipids identical to those in skin and, in particular, some ceramide supplementation may improve skin conditions caused by impaired barrier function.

4 Characterization and quantification of ceramides in the nonlesional skin of canine patients with atopic dermatitis compared with controls. Lisa V. Reiter, Sheila M. F. Torres, Philip W. Wertz, Veterinary Dermatology, Volume 20, Issue 4, pages 260–266, August 2009

GENERAL CLEANSING/ ANTIPRURITIC

ANTIBACTERIAL/ ANTIFUNGAL

ANTIMICROBIAL/ ANTISEBORRHEIC

ANTI-INFECTIVES

Dechra Veterinary Products US and the Dechra D logo are registered trademarks of Dechra Pharmaceuticals PLC.May 2015

• Introduction of TrizEDTA into the bacteria’s environment leads to the release of lipopolyscaccharides, proteins, and phospholipids from the cell wall increasing susceptibility to active ingredients.

• TrizEDTA lowers the bacterial minimum inhibitory concentration (MIC) or, how much of an active ingredient is required to inhibit an organism’s growth.

1. Koch, S.N. (2012). Canine and Feline Dermatology Drug Handbook. Ames: Wiley-Blackwell