pathogenic processes in asthma and copd

Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

Keystone Symposia is pleased to present

Pathogenic Processes in Asthma and COPD joint with the meeting on Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology

Scientific Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston

January 10–15, 2013 | Santa Fe Community Convention Center | Santa Fe, New Mexico | USA

Chronic obstructive pulmonary disease (COPD) and asthma continue to be important causes of morbidity, mortality and healthcare costs worldwide. However, their underlying causes

remain poorly understood, even as their incidence of continues to increase. Recent discoveries have uncovered strong associations between both lung function and immune responses in early life and the subsequent development of persistent asthma and chronic airway obstruction in adulthood. The meeting’s overall goal is to draw together investigators from multiple disciplines doing work relevant to understanding the genetic, epigenetic and environmental factors and mechanisms that affect the development of asthma and COPD. Specific goals include: > Explore recent insights into the genetic and epigenetic origins

of asthma and COPD; > Understand the relationship between early life environmental

exposures and impaired lung function throughout life; > Dissect the relationship between lung infections as well as

changes in the intestinal microbiome and the development of chronic lung diseases;

> Understand the role of newly described innate immune cell populations and pathways in the development of lung inflammation;

> Elucidate recent insights into the mechanisms of lung development, repair and remodeling;

> Explore unique pathways of resolution of lung inflammation. By bringing together a critical mass of multidisciplinary researchers, the symposium should provide an ideal forum for exploring novel prevention and treatment strategies for these chronic respiratory diseases based on the identification of the genetic and environmental factors that interactively cause them.

Session Topics: > New Insights into the Pathogenesis of Lung Diseases > Infectious Origins of Lung Disease > Innate Helper Cells in Type 2 Immunity > Role of Th17 Cells in the Regulation of Lung Immunity > Lung Development, Repair and Remodeling > Mechanisms of Chronic Obstructive Pulmonary Disease > Initiating Type 2 Immunity > Therapeutic Opportunities in Asthma and COPD

Abstract & Scholarship Deadline: September 10, 2012Late-Breaking Abstract Deadline: October 10, 2012Early Registration Deadline: November 8, 2012Note: Scholarships are available to students and postdoctoral fellows and require a brief application and submission of an abstract. Short talk speakers will also be selected from abstracts. Early registration saves US$150 on later fee. Information shown is subject to possible change. Please visit meeting website for the most up-to-date program information.

www.keystonesymposia.org/13J2

Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

1.970.262.1230 | 1.800.253.0685 (US & Canada)

THURSDAY, JANUARY 10

Arrival and Registration

Welcome and Keynote Address (Joint) Bart N. Lambrecht, VIB - UGent, BelgiumThe Lung Dendritic Cell Network and the Response to Allergens

FRIDAY, JANUARY 11

Adaptations to Chronic Helminth Infection (J1)*Judith E. Allen, University of Edinburgh, UKFred D. Finkelman, University of Cincinnati, USAOverview of Adaptations to Intestinal HelminthesMaria Yazdanbakhsh, Leiden University Medical Center, NetherlandsHuman Helminth Infections, Immune Responses and theirConsequence Ajay Chawla, University of California, San Francisco, USAMetabolic Consequences of Type 2 ImmunityAndrew S. MacDonald, University of Edinburgh, UKShort Talk: Epigenetic Control of Th2 Induction by Dendritic CellsIlaria Mosconi, Global Health Institute, SwitzerlandShort Talk: Differential Role of Peyer’s Patches and MesentericLymph Nodes during Helminth InfectionHermelijn H. Smits, Leiden University Center, NetherlandsShort Talk: Human Schistosome-Induced IL-10 Producing CD1dhi BCells Regulate Effector T Cell ResponsesMark A. Travis, University of Manchester, UKShort Talk: The TGFbeta-Activating Integrin alphavbeta8 on DendriticCells Regulates Type 2 Immunity in the Intestine to Promote ChronicParasitic Infection

New Insights into the Pathogenesis of Lung Diseases (J2)*Donata Vercelli, University of Arizona, USASally E. Wenzel, University of Pittsburgh, USAEmerging Concepts on Asthma HeterogeneityFernando D. Martinez, University of Arizona, USAEarly-Life Origins of Chronic Obstructive Pulmonary DiseaseAvrum Spira, Boston University, USAMolecular Insights into COPD via Transcriptomic ProfilingIan M. Adcock, Imperial College London, UKEpigenetic Regulation of Lung DiseasePeter McErlean, Northwestern University, USAShort Talk: Asthma Exacerbations during Acute Respiratory Illnessare Characterized by Distinct Expression Profiles of Immunoregulatoryand Cellular Repair Genes in the Nasal Mucosa

Gabriela Wlasiuk, University of Arizona, USAShort Talk: Epigenetic Predictors of Childhood Asthma are Detectablein the Methylome at Birth

Regulating the Type 2 Cytokines (J1)*Fred D. Finkelman, University of Cincinnati, USADirk E. Smith, Amgen, Inc., USAThe Role of IL-33 in Regulating Innate Airway InflammationSteven F. Ziegler, Benaroya Research Institute, University ofWashington School of Medicine, USATSLP in the Regulation of Type 2 ImmunityRichard M. Maizels, University of Edinburgh, UKModulation of the Host Immune Response by Parasitic HelminthsToshinori Nakayama, Chiba University, JapanShort Talk: Sox4 Acts as a Downstream Target of TGFbeta andSuppresses GATA3-Induced Th2 Cell DifferentiationBarbara Platzer, Boston Children's Hospital, USAShort Talk: Dendritic Cells use IgE as an Antigen Sensor forRegulating Th2 Immunity

Infectious Origins of Lung Disease (J2)*Jay K. Kolls, University of Pittsburgh School of Medicine, USAJames E. Gern, University of Wisconsin, USAVirus Infections and Asthma Inception and ExacerbationSebastian L. Johnston, Imperial College London, UKMechanisms of Rhinovirus-Induced Exacerbations in Asthma andCOPDMichael J. Holtzman, Washington University, USAEpithelial-Immune Cell Collaboration for Chronic Airway DiseaseDerek E. Byers, Washington University, USAShort Talk: Predominant Role of IL-33 as the Upstream Inducer ofIL-13-Mediated Chronic Airway Disease

Poster Session 1

SATURDAY, JANUARY 12

Innate Helper Cells in Type 2 Immunity (Joint) *David Voehringer, University Hospital of Erlangen, GermanyAndrew N.J. McKenzie, Medical Research Council, UKIL-25 and IL-33 Regulation of ILC2 in Protective Immunity and AllergyHergen Spits, University of Amsterdam, NetherlandsThe Spectrum of Human Innate Lymphoid CellsRichard M. Locksley, University of California, San Francisco, USAFunction-Marking Innate Helper Type 2 CellsShigeo Koyasu, Keio University School of Medicine, JapanCritical Role of GATA3 in Natural Helper Cell Differentiation andFunction

* Session Chair † Invited but not yet accepted Program current as of December 14, 2012. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/13J2 and www.keystonesymposia.org/13J1.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Pathogenic Processes in Asthma and COPD (J2)Scientific Organizers: Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston

Supported by the Directors' Fund

Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)Scientific Organizers: Richard M. Locksley and Judith E. Allen

January 10-15, 2013 • Santa Fe Community Convention Center • Santa Fe, New Mexico, USASupported by an educational donation provided by Amgen

Abstract & Scholarship Deadline: September 10, 2012 / Late-Breaking Abstract Deadline: October 10, 2012 / Early Registration Deadline: November 8, 2012

Laurel A. Monticelli, University of Pennsylvania, USAShort Talk: Innate Lymphoid Cells Promote Airway Epithelial Repairthrough the Amphiregulin-EGFR Pathway

Poster Session 2

Workshop 1: Molecular Regulation of Allergic Responses (J2)*Clare M. Lloyd, Imperial College London, UKJennifer L. Ather, University of Vermont, USASerum Amyloid A Downregulates Bim Expression and Caspase-3Activation in Serum-Starved Bone Marrow Derived Dendritic Cellsand Induces Glucocorticoid Resistance in CD4+ T CellsSofia Tousa, Biomedical Research Foundation of the Academy ofAthens, GreeceActivin-A-Induced Human Regulatory T Cells: Novel Controllers ofAllergic AsthmaElizabeth A. Jacobsen, Mayo Clinic, USAActivated Pulmonary Eosinophils Are Necessary for Th2 PulmonaryInflammation Hiromasa Inoue, Kagoshima University, JapanRole of Leukotriene B4 Receptor BLT2 in Allergic Airway InflammationPurvi Mehrotra, Indiana University School of Medicine, USAPARP-14 and its Enzyme Activity Regulates Th2 Differentiation andAllergic Airway DiseaseDavid J. Cousins, King's College London, UKIn vitro Differentiation and Transcriptome Profiling of Human Th9 CellsTao Liu, Brigham and Women’s Hospital, Harvard Medical School,USADeficiency of Inducible PGE2 is Sufficient to Cause Aspirin Sensitivityin the Setting of Pulmonary Inflammation

Adaptive Th2 and TFH Cells (J1)*Richard M. Locksley, University of California, San Francisco, USAK. Mark Ansel, University of California San FranciscoMicroRNA Regulation of TFH and Th2 Cell DevelopmentShane Crotty, La Jolla Institute for Allergy and Immunology, USAThe Relationship between Th2 and Tfh Cells: Defining Characteristicsof Tfh Cell Differentiation and FunctionMatthew D. Taylor, University of Edinburgh, ScotlandShort Talk: Th2 Cell Intrinsic Hypo-Responsiveness DeterminesSusceptibility to Helminth Infection via the PD-1/PD-L2 PathwayFabienne Andris, Université Libre de Bruxelles, BelgiumShort Talk: The Capacity of Th2 Lymphocytes to Deliver B Cell HelpRequires Expression of the Transcription Factor STAT3

Nicholas van Panhuys†, NIAID, National Institutes of Health, USAShort Talk: TCR Strength of Signal is Upstream of and DominatesOver Cytokine Effects in Controlling CD4+ T Cell Polarization in VivoChristopher D.C. Allen, University of California, San Francisco, USAShort Talk: Regulation of IgE+ B Cell Responses Revealed by NovelFluorescent Reporter Mice

Role of Th17 Cells in the Regulation of Lung Immunity (J2)*Hergen Spits, University of Amsterdam, NetherlandsJay K. Kolls, University of Pittsburgh School of Medicine, USATh17 Cells in the Regulation of Lung Immunity Susan V. Lynch, University of California, San Francisco, USAAirway Microbiota and Lung DiseaseMarsha Wills-Karp, Johns Hopkins Bloomberg School of PublicHealth, USAColonization with Segmented Filamentous Bacteria Drives SevereAsthma through an IL-17A-Dependent MechanismSaheli Chowdhury, Academic Medical Center, NetherlandsShort Talk: Exposure to IL-17 Reveals Defective mRNA Degradationby Bronchial Epithelial Cells in 70% of Patients with Asthma

SUNDAY, JANUARY 13

Commensals, Immunity and Epithelial Homeostasis (J1)*Hajime Karasuyama, Tokyo Medical and Dental University,Graduate School, JapanWenjun Ouyang, Genentech, Inc., USARegulation and Function of IL-22 on Epithelial CellsYasmine Belkaid, NIAID, National Institutes of Health, USACommensal-Pathogen Interactions at Barrier SitesSabine Eming, University of Cologne, GermanyTissue Repair and Type 2 ImmunityDe'Broski R. Herbert, University of California, San Francisco, USAShort Talk: Trefoil Factor 2 Initiates IL-33 Production forNon-Canonical Type 2 Immunity against Murine Hookworm InfectionSoichiro Yoshikawa, Tokyo Medical and Dental University, JapanShort Talk: Mechanisms Underlying the Recruitment, Accumulationand Activation of Basophils at Tick-Feeding Sites for ProtectiveImmunity to Tick Re-InfestationP'ng Loke, NYU School of MedicineShort Talk: Type 2 Immunity in Helminth Treatment for InflammatoryBowel Diseases

Lung Development, Repair and Remodeling (J2)*Fernando D. Martinez, University of Arizona, USA








Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center,USAEpigenetic and Genetic Regulation of Goblet Cell Metaplasia andAntiviral Innate Immunity by FOXA3Paul W. Noble, Duke University, USAMatrix Regulation of Lung Injury, Inflammation and RepairStephanie C. Eisenbarth, Yale University, USANOD-Like Receptors and the Regulation of Lung InflammationJoanne L. Wright, University of British Columbia, CanadaCigarette Smoke Induced COPD - Use of Animal ModelsHesam Movassagh, University of Manitoba, CanadaShort Talk: Semaphorin 3E Inhibits Human Airway Smooth MuscleCell Proliferation and MigrationSejal Saglani, Imperial College London, UKShort Talk: Interleukin-33 Promotes Airway Remodelling in PaediatricSevere Steroid Resistant Asthma

Myeloid Cells in Tissue Homeostasis (J1)*Richard M. Maizels, University of Edinburgh, UKJudith E. Allen, University of Edinburgh, UKMacrophages in Helminth Infection: Where Inflammation isAnti-InflammatoryDavid Voehringer, University Hospital of Erlangen, GermanyEosinophil and Basophil Responses to Allergens and HelminthsHajime Karasuyama, Tokyo Medical and Dental University, GraduateSchool, JapanBasophil as a Crucial Player in Acquired Immune ResponsesCarla V. Rothlin, Yale University, USAShort Talk: TAMing Type 2 Immunity

Mechanisms of Chronic Obstructive Pulmonary Disease (J2)*Sebastian L. Johnston, Imperial College London, UKShyam Biswal, Johns Hopkins School of Public Health, USAOxidative Stress Regulation of Lung Inflammation in COPDAugustine Choi, Harvard Medical School, USARegulation and Function of Autophagy in COPDFarrah Kheradmand, Baylor College of Medicine, USAAutoreactive T Cells in The Pathophysiology of Human and MouseEmphysema Chandran Nagaraj†, Ludwig Boltzmann Institute for Lung VascularResearch, AustriaShort Talk: p22phox Regulates House Dust Mite (HDM) InducedAllergic Airway Inflammation

Poster Session 3

MONDAY, JANUARY 14

Initiating Type 2 Immunity (Joint) *Andrew N.J. McKenzie, Medical Research Council, UKJean-Philippe Girard, CNRS, FranceIL-33 Processing and Activation by Inflammatory ProteasesJenny P.-Y. Ting, University of North Carolina at Chapel Hill, USANLRs and Type 2 ImmunityMarco Idzko, University Hospital Freiburg, GermanyATP and P2X Receptors in Type 2 ImmunityJack A. Elias, Yale School of Medicine, USAChitinase-like Moieties in Lung Inflammation, Injury and RepairLaura J. Simpson, University of California, San Francisco, USAShort Talk: miRNA Expression in CD4 T Cells from Asthmatic AirwaysTakehiko Shibata, University of Michigan Medical School, USAShort Talk: Gas6/TAM Signaling Differentially Modulates ChronicFungal Asthma with the Expansion of Myeloid Regulatory CellSubsets in Mice

Workshop 2: Viral Infections and Exacerbations of Lung Disease(J2)*Marsha Wills-Karp, Johns Hopkins Bloomberg School of PublicHealth, USACharles S. Dela Cruz, Yale University, USACigarette Smoke Exposure Enhances Interleukin-15, NK and CD8 TCell Responses during Influenza Virus Infection in Models of COPDJenny Calvén, Lund University, SwedenViral Stimuli and Epithelium-Derived Mediators Trigger CytokineExpression in Bronchial Smooth Muscle CellsSumit Ghosh, North Dakota State University, USAHyaluronic Acid Impacts B Lymphocyte Recruitment and Function in aMurine Fungal Allergic Asthma ModelAmali E. Samarasinghe, St. Jude Children's Research Hospital, USAAllergic Eosinophils Enhance Anti-Viral Defenses in a MurineCo-Morbidity Model of Asthma and InfluenzaTamlyn Peel, Imperial College London, UKIL-17 Modulation of Rhinovirus-Induced Allergic Airways DiseaseLara Ravanetti, Academic Medical CenterInfluenza-Induced Exacerbation in a Murine Chronic House Dust Mite(HDM) Asthma ModelKristen N. Kindrachuk, National Institutes of Health, USAMuc5ac-Deficiency Exacerbates Bleomycin-Induced AirwayInflammation

Pathologic Syndromes (J1)*Jack A. Elias, Yale School of Medicine, USAStuart G. Tangye, Garvan Institute of Medical Research, AustraliaLymphocyte Defects in Hyper-IgE Syndromes








Thomas A. Wynn, NIAID, National Institutes of Health, USAMacrophages and Mucins in the Pathogenesis of Type 2 Immunity Lawren C. Wu, Genentech, Inc., USATherapeutic Targeting of IgE-Switched Cells in AsthmaMark S. Wilson, National Institute for Medical Research, MedicalResearch Council, UKShort Talk: miR-182 and miR-10a Are Key Regulators of TregSpecialisation and Stability during Th2 and Th1-AssociatedInflammationAdam Matson, University of Connecticut Health Center, USAShort Talk: Maternal Allergy Is Associated with Surface-Bound IgE onCord Blood Basophils

Therapeutic Opportunities in Asthma and COPD (J2)*Sally E. Wenzel, University of Pittsburgh, USAAili Lazaar, GlaxoSmithKline, USAChallenges and Opportunities in COPD Drug DevelopmentJohn G. Matthews, Genentech, Inc., USATreatment of Adult Asthmatics with the Anti-IL-13 LebrikizumabAlison L. Budelsky, Amgen Inc., USABlockade of IL-17RA in AsthmaSofie Lock Johansson, Institut for Molecular Medicine, DenmarkShort Talk: Microfibril Associated Protein 4 (MFAP4) Is Associated toDyspnea and the Composite BODE Index in COPD

TUESDAY, JANUARY 15

Departure








pathogenic processes in asthma and copd

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