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Vidal Sassoon

MX1002-PAS-Wk7-RS

PAS-Respiratory Pathophysiology

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PathophysiologyRespiratory SystemDr. Venkatesh M. Shashidhar.Associate Professor & Head of Pathology

MX1002-PAS-Wk7-RS

PAS-Respiratory Pathophysiology

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Introduction to Resp. Sys:10,000L/day of air filtered, moistened, warmed, O2/Co2. exchanged.!Full capacity 6L. (500ml at rest)Sinusitis, pharyngitis, laryngitis* URIPneumonia: Inflammation of lung * LRIChronic: COPD, Fibrosis Smoking.Commonest internal Cancer.Respiratory tract inflammations - commonest in medical practice.Enormous morbidity & mortality.Important medical learning.Doctors daily bread.!

PAS-Respiratory Pathophysiology

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Normal Lung

PAS-Respiratory Pathophysiology

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Respiration Respiratory system:5

PAS-Respiratory Pathophysiology

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Respiration Respiratory system:6

PAS-Respiratory Pathophysiology

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Normal Lung

PAS-Respiratory Pathophysiology7

Alveolar Gas Exchange:8

Co2O2

PAS-Respiratory Pathophysiology

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Lung Function testing:9

Expiration

0 ------- Volume ---------------6L

Inspiration

PAS-Respiratory Pathophysiology

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Lung Function Testing:Total Lung Capacity (TLC) 6L male/4.7L fem.Tidal Volume (TV) 500 / 390mlForced Vital Capacity (FVC) 4.8L / 3.7LForced Expiratory Volume in 1 Sec - FEV1FEV1/FVC (FEV1%) - 7580% normal. In Obstructive diseases (COPD) FEV1 low & FVC high. So FEV1/FVC is low (