pathology of the esophagus
TRANSCRIPT
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Pathology of the EsophagusComplete info
By- Dr. Armaan Singh
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Embryologic Development of the Esophagus
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Embryologic Development of the Esophagus
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Surgical Diseases of the Esophagus
1. Hiatal Hernia
2. Reflux esophagitis
3. Esophageal motility disorders
4. Cancer
5. Esophageal disruption and trauma
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Clinical Divisions of the Esophagus
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Esophagus Upper 1/3 is skeletal muscle Lower 1/3 is smooth muscle middle is combo of both Contains two sphincters Lined by squamous epithelium < 3 cm below diaphragm
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Vascular Supply to Esophagus
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Nerve Supply of the Esophagus
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Motility -- Manometry
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Esophageal Dysmotility
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Factors Affecting Reflux
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Esophageal Function Tests
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Hiatal Hernia and Reflux Esophagitis
Pathogenesis
two major types of hiatal hernia type I or "sliding" hiatal hernia type II paraesophageal hiatal hernia
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Hiatal Hernia Types
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Hiatus Hernia - Clinical Presentation Sliding hiatal hernias are more common than
paraesophageal hernias by 100:1 The lower esophageal sphincter mechanism becomes
incompetent Reflux of acid gastric juice produces a chemical burn Degree of mucosal injury is a function of the duration of acid
contact and not a disease of hyperacidity
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Hiatus Hernia - Clinical Presentation
Continued inflammation of the distal esophagus may lead to mucosal erosion, ulceration, and eventually scarring and stricture
Predominantly in women who have been pregnant Men and women with increased intraabdominal pressure
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Clinical Presentation – Type I hernia
Type I hiatal hernia with reflux is frequently found in patients who are overweight.
Many patients with type I hiatal hernia have no symptoms. A burning epigastric or substernal pain or tightness Usually the pain does not radiate May be described as a tightness in the chest and can be
confused with the pain of myocardial ischemia
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Clinical Presentation – Hiatus Hernia
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Hiatus Hernia - Clinical Presentation
Worse when the patient is supine or leaning over Antacid therapy frequently improves the symptoms. A lump or feeling that food is stuck beneath the xyphoid Alcohol, aspirin, tobacco, and caffeine, may exacerbate the
symptoms Late symptoms of dysphagia and vomiting usually suggest
stricture formation
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Hiatus Hernia - Clinical Presentation Type II hernias
Generally produce no symptoms until they incarcerate and become ischemic
Dysphagia, bleeding, and occasionally respiratory distress are the presenting symptoms.
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Clinical Presentation – Paraesophageal Hernia
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Diagnosis- Hiatus Henia
Usually suspected based on the patient's history Weight loss is a feature due to distal esophageal stricture Hiatal hernia and reflux esophagitis can be confirmed by
fluoroscopy during a barium swallow
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Barium Swallow – Type I hiatus Hernia
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Diagnosis – Hiatus Hernia
Esophagogastric endoscopy and biopsy of the inflamed esophagus
Manometry may show a loss of the lower esophageal high-pressure area
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Treatment – Hiatus Hernia
Medical Therapy 1. Avoidance of gastric stimulants (coffee, tobacco, and
alcohol).
2. Elimination of tight garments that raise intraabdominal pressure, such as girdles or abdominal binders.
3. The regular use of antacids ( coat the esophagus), and antacid mints (Tums and Rolaids) to provide a steady stream of protection.
H2 blockers, to increase the pH of the refluxed gastric juice
Metoclopramide (Reglan) to stimulate gastric emptying without
stimulating gastric, biliary, or pancreatic secretions
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Treatment – Hiatus Hernia
4. Abstinence from drinking or eating within several hours of sleeping.
5. Sleeping with the head of the bed elevated to reduce nocturnal reflux.
6. Weight loss in obese patients.
About one third of patients fail to respond to initial medical treatment, and half of those who initially respond will ultimately relapse and require surgery.
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Treatment Hiatus Hernia -- Surgical
Correct the anatomic defect Prevent the reflux of gastric acid into the lower esophagus by
reconstruction of a valve mechanism
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Treatment Hiatus Hernia -- Surgical
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Treatment Hiatus Hernia -- Surgical
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Hiatus Hernia
Complications post surgery
inability to belch or vomit- the "gas-bloat" syndrome
DysphagiaDisruption of the repair with recurrent
symptoms intraabdominal infection esophageal perforation Splenic injury
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Bochdalek Hernia Congenital, left lateral area of diaphragm Through the pleuroperitoneal foramen of Bochdalek Symptoms of cyanosis, dyspnea, vomiting Treatment: surgery in first 48 hours of life
Also – retrosternal hernia through foramen of Morgagni in older children
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Diaphragmatic HerniaBochdalek
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Diaphragmatic HerniaBochdalek
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Esophageal Motility DisordersAchalasia Failure to relax Not due to spasm Failure of the high-pressure zone sphincter to relax Painless dysphagia Progressive dilation of the proximal esophagus
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Esophageal Motility DisordersAchalasia -- Clinical Presentation Dysphagia Regurgitation of undigested food Weight loss Pain in this condition is uncommon Aspiration pneumonia is common Complain of spitting up foul-smelling secretions when simply
leaning forward
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Esophageal Motility DisordersAchalasia -- Diagnosis
Generally first confirmed roentgenographically by contrast studies of the esophagus
Dilation of the proximal esophagus is classic
Esophageal diverticula may be present at any level
Endoscopy -- one needs to be particularly careful to avoid diverticular perforation
Esophageal manometry
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Esophageal Motility DisordersAchalasia -- Treatment Medical treatment has generally not been helpful Invasive endoscopic procedure --forceful dilation Surgical transaction of the muscle -- esophageal myotomy
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Esophageal Motility DisordersAchalasia
Sshove this down your own
throat
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Esophageal Motility DisordersAchalasia
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Esophageal Motility DisordersAchalasia
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Esophageal Motility DisordersAchalasia
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Esophageal Motility DisordersEsophageal Diverticulum
The second most common manifestation of esophageal motility disorders
Pulsion or Traction, depending on the mechanism that leads to their development
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Esophageal Motility DisordersEsophageal Diverticulum
Upper third cervical esophageal diverticula - usually pulsion
Cervical diverticula, or Zenker's -- pulsion and are closely related to dysfunction of the cricopharyngeal musclea) complain of regurgitation of recently
swallowed food or pills, choking, or a putrid breath odor
b) treated by excision of the diverticula and myotomy of the cricopharyngeal muscle
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Esophageal Motility DisordersEsophageal Diverticulum – Zenker’s
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Esophageal Motility DisordersEsophageal Diverticulum
Middle-third esophageal diverticula are almost always traction, not related to an intrinsic abnormality in esophageal motility
a) Result of mediastinal inflammation (usually inflammatory nodal disease from tuberculosis or
histoplasmosis, with formation and subsequent contracture that places "traction" on the
esophagus
b) Usually asymptomatic and do not warrant
treatment.
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Esophageal Motility DisordersEsophageal Diverticulum
Diverticula of the distal third of the esophagus
a) associated with dysfunction of the esophagogastric junction due to chronic stricture from acid reflux, antireflux surgical procedures, achalasia
b) Excision of these diverticula should always be accompanied by correction of the underlying pathologic process
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Esophageal NeoplasmsBenign
Exceedingly rare – in middle and distal 1/3 Leiomyomas are the most common intramural tumors
1) potential for malignant degeneration appears to be quite low
2) indent the lumen of the esophagus on contrast radiography
3) tend to grow progressively and cause dysphagia
3) Excised for possible dysphagia and malignancy
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Esophageal NeoplasmsMalignant
85% are squamous cell carcinomas
10% are adenocarcinomas
< 1% are malignant melanoma
Adenoid cystic tumors, sarcomas, APUDomas are rare
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Esophageal NeoplasmsMalignant
Usually arises from squamous epithelium Commonly occurs in association with alcohol and/or tobacco
abuse Etiology has been related to diet, vitamin deficiency, poor oral
hygiene, surgical procedures, and a number of premalignant conditions, (caustic burns, Barrett's esophagus, radiation, Plummer-Vinson syndrome, and esophageal diverticula).
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Esophageal NeoplasmsMalignant
Weight loss and pain may be present Difficulty in swallowing Acquired tracheoesophageal fistula due to erosion of the
tumor into the trachea or bronchus Frequent episodes of pneumonia due to recurrent aspiration
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Esophageal NeoplasmsMalignant -- Diagnosis Barium contrast studies of the esophagus
Endoscopy and biopsy of the lesion
The extent of tumor involvement assessed by computed tomography (CT) of the chest and upper abdomen .
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Esophageal NeoplasmsMalignant -- Diagnosis
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Esophageal NeoplasmsMalignant
Approximately 10% of patients with Barrett's esophagus will develop adenocarcinoma
Symptoms produced by an esophageal malignancy frequently insidious at the onset, precluding early diagnosis and
thus the opportunity for effective treatment As the tumor enlarges progressive dysphagia becomes the
predominant symptom
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Esophageal NeoplasmsMalignant -- Treatment Tumors that involve the middle third of the esophagus are
usually treated by a staged procedure with total thoracic esophagectomy and bypass
Cancer involving the lower third of the esophagus or proximal stomach is best treated by esophagogastric resection and an end-to-end anastomosis in the midchest.
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Esophageal NeoplasmsMalignant -- Treatment
Squamous or adenocarcinomas of the esophagus - very poor prognosis
Palliation - restoration of effective swallowingRadiotherapy - primary mode of treatment for cancer
arising in the upper esophagusSurgical treatment of upper third usually
requires extirpation of the esophagus en bloc with the larynx, permanent tracheostomy, and restoration of swallowing by a free microsurgically constructed vascular pedicle of jejunum or colon into the neck.
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Traumatic Rupture of the Diaphragm
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Traumatic Esophageal DisordersPerforation
Instrumentation by endoscopic and/or biopsy Passage of blind nasogastric tubes Instruments designed for dilation of strictures Sengstaken-Blakemore tubes, balloon dilation for alchalasia Boerhaave’s syndrome -- spontaneous perforation secondary to forceful
vomiting (Plummer-Vinson) Treatment requires aggressive surgical intervention
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Traumatic Esophageal DisordersPerforation -- Symptoms May be dramatic or occult Profound shock Mediastinal sepsis Severe chest or abdominal pain Hypotension Diaphoresis Nausea/Vomiting
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Corrosive Gastritis Due to Acetic Acid
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Hydrochloric Acid Corrosion
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Hydrochloric Acid Corrosion
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Pyloric Obstruction after Lye Gastritis
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Traumatic Esophageal DisordersIngestion of Caustic Materials Medical Emergency Drano, Liquid Plumber -- alkaline containing products Inspect mouth to assess injury Neutralization and induced emesis not usually
recommended Endoscopy, airway maintenance, patency of the
esophagus No steroids
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Diaphragmatic HerniaLarrey
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Diaphragmatic HerniaLarrey
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Traumatic Rupture of the Diaphragm
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Traumatic Rupture of the Diaphragm
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Traumatic Rupture of the Diaphragm
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Old Traumatic Rupture of the Diaphragm
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Old Traumatic Rupture of the Diaphragm