pathology practicals 3 (part 3)
TRANSCRIPT
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Pathology Practicals 3 (Part 3)Endocrine, Breast, Urinary System
By: Jeffrey James Co :D
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** Remember! Grave¶s Disease, Papillary Carcinoma (Thyroid),Hashimoto¶s (Chronic Lymphocytic) Thyroiditis
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Pituitary Adenoma
Basilar Artery
Pituitary Adenoma
Olfactory Bulb
Hx: 54 yo male complained of severe frontalheadache and blurring of vision of 2 weeksduration.
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normal vs pituitary adenoma
Diffuse pattern, cells arranged in sheets, closely packed, supported by scantfibrovascular stroma and absence of reticulin.
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Adenoma
ResidualTissue
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Normal Thyroid
Colloid
Parafollicular cells
Follicular cells
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Hx: 50 yo women, enlarged mass on neck
Clinical Features:
Goiter, Hypothyroidism, Increased TSH, Low T3and T4 levels
Hurthle or Askanazy Cells
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Hashimoto (Auto-Immune)
(Lymphoid follicles with germinal centers
Subacute Lymphocytic (just like
Hashimoto¶s but NO fibrosis and no
germinal centers), often post-partum
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Diffuse Non-toxic (Simple) Goiter
Hx: 59 yo female, non-tender, large anterior neck mass
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Gross: Enlarged, doughy,purplish to reddish-brown
Microscopy: Enlargedirregular Thyroid Follicles with excessive colloid
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Graves disease (diffuse toxic goiter)
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Low TSH, Hyperthyroidism,
Hx: 29 yo female non-tender, large anterior neck mass
SCALLOPING
APPEARA NCE!
(Yung mga butas butas sasides)
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Follicular adenoma
Hx: 24 yo female mass solitary
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Normal
Follicular Adenoma
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Papillary Carcinoma
Hx: 54 yo male, pricking pain and dyspnea
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ORPHA N A NNIE CELLS (Clear Ground Glass)
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P A PILLARY
AR IN MA
PSAMMOMA BODIES
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Tumors: Adrenal cortexexternal surface in the left photo shows a yellow-tan color. The cut surface inthe right photo is hemorrhagic, of a yellow-pink-tan color, and shows minorcystic change.
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Adrenocortical carcinoma
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Adrenocortical carcinoma
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Hindi ko na lahatin, lalagay ko nalang yun pinakasure lalabas..:D
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Fibroadenoma
Hx: 20 yo female, tender mass o the right breast
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Hx: 53 yo female, 4 yrs past her menopause w/ tumor of increaseing size in the breast
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Microscopy: Spindly and stellate,myxomatous stromal cells w/ areas of necrosis and hemorrhages
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MAY DELINEATIONS PA FROM NORMAL A ND ABNORMAL CELLS
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DISTORTED CAPSULE
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INDIA N FILING
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AUTOSOMALDOMIN A NTPOLYCYSTIC
KIDN
EY DISEASE
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MUST K NOW!!! :D
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Pathogenesis:Secondary to congenital obstruction of theureteropelvic junction.
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Wilms tumor resembles the developing fetal nephrogenic zone of the kidney.The tumor shows attempts to form primitive glomerular and tubularstructures. Pediatric neoplasms are often composed of cells that resembleprimitive embryonic counterparts: -blasts. In this case the cells arereminiscent of developing nephroblasts.
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Composition of Urine
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Composition of Urine
1. Chemical Constituent: NaCl, Urea (Most impt)
2. Microscopic Constituent: RBC, WBC, Epithcells, Casts, Crystals
Normal Volume of urine: 1200-1500ml/day
Normal Spec.Gravity: 1.016-1.022 Normal pH: 4.6-8
Normal Protein: 150mg/24hrs or 10mg/dl
Renal Glucose Threshold: 160-180mg/dl RBC : 0-2/HPF
WBC: 0-5/HPF
Epithelial Cells: >3 is ischemic necrosis
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CastsFactors affecting cast formation:
1. pH: acidic2. Concentrated urine3. Proteinuria4. Stasis or obstructionTypes of Casts:1. Matrix Casts: Hyaline- glomeruloneph, pyeloneph, Chronic renal dse,
CHF Waxy- Stasis or urine flow 2. Cellular Casts: RBC ± glomeruloneph, strenuous exercise
WBC ± pyeloneph, acute interstitial neph Epithelial cells ± Renal Tubular Damage Mixed cells3. Inclusion Casts: Granular Casts, Fatty casts, Hemosiderin Casts
RBC CASTS!
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RBC CASTS!
WBC Casts
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WBC Casts
Hyaline Casts
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Hyaline Casts
Epithelial Cell Casts
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Epithelial Cell Casts
Waxy Casts
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Waxy Casts
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Granular Cast
Fatty Casts Hemosiderin Casts
OFB = Oval Fat Body
Crystals
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CrystalsNormal Acid Urine:
Amorphous UratesCrystalline urates
Crystalline Uric Acid
Calcium Oxalate
Normal Alkaline Urine Crystalline phosphates
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Amorphous Phosphate
Calcium carbonate Ammonium biurate
Abnormal Crystals
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Cystine Tyrosine
Sulfonamide
Leucine
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YOU HAVE NOW FINISHED THE LAST
PART!!!! PASADO KANA! LOL :PGOOD LUCK! :D