pathophysiology of nontoxic nodular goiter
TRANSCRIPT
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7/24/2019 Pathophysiology of Nontoxic Nodular Goiter
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Pathophysiology of Non-toxicNodular Goiter
Precipitating Factors:
Diet
History of Radiation
Regular intake of
substances (Goitrogens)
Predisposing Factors:
Age
Gender
Genetics
Geographic
Decreased/uppression of
synthesis of thyroid
hor!ones
"sche!ic necrosis of
e#panding follicles
Heterogeneous gro$th of
thyroid follicles
%egati&e feedback:
"ncreased production of
Decreased ' and ' in
the body
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*isible andpalpable
!ass
'reat!ent:
'hyroidecto!y
Radioacti&e "odinetherapy
Pressure on
anterior
Pressure on
recurrent
laryngeal
Dyspnea
,oughing
-hee.ing
Hoarseness
Dysphagia
Facial
plethora ngorge!ent
Pressure on
trachea
Pressure on
esophagus
*enous out0o$
obstruction ofthe head and
Death
Heart Failure
'hyroid tor!
1ay lead to
'hyroto#icosis
'o#ic 1ultinodular
Goiter
'H receptor gene
!utation
Functional
autono!y of
Gradual
enlarge!ent of the
'hyroid Gland
(%onto#ic %odular
'hyroid architecture
loses unifor!ity
De&elop!ent of
nodules