PATHOPHYSIOLOGY OF PROSTATE CANCER

Infection in the peripheral zone of prostate

Normal semen-secreting gland cells mutate

Development into cancer cells

Cancer cells can avoid apoptosis

Multiplication of cancer cells

Formation of small clumps of cancer cells (asymptomatic stage)

Spread to surrounding tissues (stroma)

Formation of tumor

Compression of urethra

Weak urine stream hematuria dysuria hematospermia polyuria

Inability to urinate nocturia

Metastasize

Invades seminal vesicles

Infects testicles

Deep pain in the lower abdomen, back, & pelvis

PROSTATE CANCER

Transurethral Resection Prostatectomy (TURP) Orchidectomy