PATHOPHYSIOLOGY (Book Based)

Sealing of the colonies of bacilli

Bacilli lodge to the upper lobe

Inspiration of bacteria (Mycobacterium

Tuberculosis) to the lungs

Migration to the lymph nodes

Initiation of immune responseInflammation of the lungs

(Pneumonitis)

Activation of alveolar macrophages and neutrophils

Phagocytosis of the bacilli

Formation of caseous necrosis

Formation of tubercle

Airborne/Droplets

Proliferation of bacilli

Collagenous scar tissue grows tubercle

Complete isolation of the bacilli in the bronchi

Bacilli becomes dormant Impairment of the immune system

Bacilli escape from the bronchi

Endogenous reactivation of dormant bacilli

Active bacteria spread through blood and lymphatic organs