7/30/2019 pathophysiologyRHD

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Predisposing Factor

Hereditary Age Sex

Precipitating Factor

Poor dental hygiene Low intake of fluids Too much intake of sweet

foods

Invasion of group A B- hemolytic streptococcus

Pharyngeal infection

Abnormal humoral and cell mediated immune response to group A

streptococcal cell membrane antigens called M Proteins.

Joints HeartSkin

Acute rheumatic fever

Diffuse, proliferate and exudative inflammatory lesions develop