patient care services nursing - lvhn scholarly works
TRANSCRIPT
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Lehigh Valley Health NetworkLVHN Scholarly Works
Patient Care Services / Nursing
Critiquing Evidence.Carolyn L. Davidson RN, PhDLehigh Valley Health Network, [email protected]
Mae Ann Pasquale PhD, MSN, RNCedar Crest College / Lehigh Valley Health Network, [email protected]
Linda M. Schwartz MDE, AHIP, CMLehigh Valley Health Network, [email protected]
Follow this and additional works at: http://scholarlyworks.lvhn.org/patient-care-services-nursing
Part of the Education Commons, and the Nursing Commons
This Presentation is brought to you for free and open access by LVHN Scholarly Works. It has been accepted for inclusion in LVHN Scholarly Works byan authorized administrator. For more information, please contact [email protected].
Published In/Presented AtDavidson, C. L., Pasquale, M. A., Schwartz, L. M. (2010, October 04). Critiquing Evidence. Presentation Presented at: Lehigh ValleyHealth Network
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Critiquing EvidenceCarolyn L. Davidson, PhD, RNMae Ann Pasquale, PhD, RNLinda Matula Schwartz, M.D.E.
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Good Afternoon!
• Objectives:
1. Discuss the purpose, evolution and importance of evidence-based practice.
– Purpose of EBP
– Overcoming “sacred cows”
2. Develop a searchable practice question.– Lit search and strategy
3. Appraise the evidence for application to clinical practice.
– Types of studies
– Implications for Practice
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Greetings from Cedar Crest College
• Passionate about EBP
• Involved since the 1990’s – Brain Trauma Foundation- what is this??
• Started in medicine first
• Evolved to nursing
• Magnet Hospitals
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So….let’s get started with a kiss!
• Purple – EBP mean to you?
• Silver – A practice you would like to see changed.
• Gold – How do you find new information?
• Striped – How do you know if the research is good?
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21st Century Healthcare
• EBP arose in the mid 1990s
– “Luxury and comfort of doing things as they were done in the past are gone.”
• Needed to reduce costs and resource consumption while maintaining quality of care.
• Expenditures will continue to grow
– Expanding elderly population
– Expansion of life saving technology
– Increased acuity of illness
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Can we get there??
• Institutions must operate with a strong sense of urgency – do more with less.
• Need to balance the needs for increased utilization with cost-effectiveness and costs.
• Cost effectiveness is essential and is absolutely expected, but NOT at the expense of quality.
Institute of Medicine (IOM), 2001
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Needed to Standardize Care
• Vast amounts of data
• Misperceptions of outcomes
– “Everything published is not sound!!
• Variations in practice
– Physician’s are inconsistent.
– Nurses are “ritualistic” and “traditionalists”.
– No one wanted to CHANGE--but we had to!!
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“Change is inevitable, except from a vending machine”
Chinese Fortune Cookie
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Nurses are ritualistic!!
• Many nurses…even today…still believe that the way we worked yesterday is the best guide for tomorrow.
• Practice is based on tradition and handed down from earlier generations.
• ....SURE PATH TO EXTINCTION!!!
• Needed vital lessons to survive and participate
in shaping our future – EBP!!
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The Concept of Research
• Research is essential to advance the science of nursing.
• Application of findings:
– Improves patient outcomes (Heater, Becker and Olson, 1988)
– Enhances the professional practice environment
– Streamlines care and costs
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“Unless research findings are applied in practice, nursing
research is little more than an ivory tower exercise.”
Dracup & Brown, 1993
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The Past.....The Future
• 1950s - Development of formal research programs --1956 editorial cautioned the need to consider the use of findings in everyday practice
• 1960s - Focused on nursing education
• 1970s - Focused on clinical practice
• 1980-1990s - Utilization of findings have “come of age”
• 21st Century - EBP
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Why Evidence-Based Practice?
• Worldwide recognition that EBP is key to delivering the highest quality of healthcare and best patient outcomes.
• EBP approach versus care that is steeped in tradition or outdated policies results in improved health, safety and cost outcomes and decreased morbidity and mortality.
McGinty & Anderson, 2008; Williams, 2004
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Optimal Outcomes
• When clinicians know how to find, critically appraise, and use the best evidence in clinical practice…..
• When patients are confident that their healthcare providers are using evidence-based care…..
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We need to ask ourselves….
• If your child was in a MVA and sustained a severe head injury, would you want the trauma practitioners to know and use the most effective, empirically supported treatment from RCTs to decrease his ICP and prevent death?
• If you were diagnosed with cancer today, would you want your health care team to share with you the best and latest evidence regarding the risks and benefits of treatment and how other patients have coped with this illness?
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We need to ask ourselves….
Can we, as healthcare professionals, continue to implement practices that
are not based on sound evidence?
If so…at what cost to our patients and their family members??
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EBP Definition
• “…conscientious, explicit, and judicious use of current best evidence in making decisions about patient care” (Sackett et al., 2000).
• “…lifelong problem-solving approach to clinical practice” (Melnyk & Fineout-Overholt, 2010).
• Unlike research utilization, which is the use of knowledge typically based on a single study, EBP takes into the consideration the expertise of the practitioner as well as pt preferences (Barnsteiner & Prevost, 2002).
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What exactly is evidence?
• External Evidence – rigorous research (RCTs) intended to be generalized to other settings
– Can the findings from research be translated to the real-world setting?
• Internal Evidence – outcomes mgt or PI projects
• Undertaken to improve the care in that setting
• Much research that is not implemented and many practices are not evidence based!
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Components of EBP
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EBP Organizational Culture
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The Starting Point - Cochrane
• Dr. Archibald Cochrane (1908-1988)- British epidemiologist
• 1972 - published a landmark book that criticized the medical profession for NOT providing rigorous reviews of evidence.
• “Thousands of premature infants died needlessly because the results of several RCT’s supporting the effectiveness of administrating corticosteroids to women in premature labor had never been compiled”.
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Cochrane Center and Collaboration
• Launched in Oxford, England, 1992
• Goal - To assist individuals in making well-informed decisions about health care by developing, maintaining and updating systematic reviews of interventions.
• Today- over 1000 systematic reviews of clinical effectiveness
• http://www.cochrane.org/
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Despite the fact that EBP:
• …leads to the highest quality of care and best outcomes (Reigle et al., 2008; Talsma et al, 2008).
• …reduces costs and geographic variation in practice (McGinty & Anderson, 2008; Williams, 2004).
• …makes clinicians feel empowered and satisfied in their roles when they engage in EBP ( Maljanian et al., 2002).
• ….may ultimately reduce burn-out and staff turnover (Titler et al, 2002).
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EBP Readiness Study
• Nursing Informatics Expert Panel of AAN
• Survey to assess readiness to engage in EBP
• Nationwide survey of 1,097 nurses– Almost half not familiar with the term EBP
– > than half did not believe that their colleagues use research findings in practice
– Only 27% taught to use electronic databases
– Most did not search information databases
– Those who did search do not think they have adequate skills
(Pravikoff et al., 2005)
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Without EBP…
• Practice is rapidly outdated– Prone position to “Back to Sleep” guidelines (AAP, 2000).
• Hospitals are beginning to be denied payment for complications that develop when EBP guidelines are not followed.
• Patients and family members are seeking the latest evidence on the internet.
• Evidence continually evolves– Prempro study
– Metforman study
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EBP is difficult to achieve….
• Despite an aggressive research movement, the majority of findings from research often are still not being integrated into practice.
• It takes approximately 17 years to translate research findings into practice! (Melnyk & Fineout-Overholt , 2010)
• “Patients should receive care based on the best available scientific knowledge. Care should not vary from clinician to clinician or from place to place” (IOM,
2001).
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Key EBP Initiatives
• IOM’s Roundtable on Evidence-based Medicine– 2020 – 90% of decisions based on best/current evidence
– Senior leadership from multiple sectors so better evidence can be generated and applied
• United States Preventative Services Task Force– Independent panel of expert, sponsored by AHRQ
– “Guide to Clinical Preventative Services”
• National Consortium for the Advancement of Pediatric and Adolescent Evidence-based Practice
• Magnet Recognition Program
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Steps of EBP
1. Cultivate a spirit of Inquiry.
2. Ask the burning question in PICOT format.
3. Search for and collect the most relevant best evidence to answer the
clinical question.
4. Critically appraise the evidence that has been collected for its validity,
reliability, and applicability, then synthesize that evidence.
5. Integrate the best evidence with one’s clinical expertise & patient.
preferences and values to implement a decision.
5. Evaluate outcomes of practice decision or practice change.
6. Disseminate the outcomes of the EBP decision or change.
Melnyk & Fineout - Overholt , 2005
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Step 0 – Cultivate a Spirit of Inquiry
• Need an environment that clinicians are excited to ask questions and challenge practices
• Key Elements– Philosophy, mission and clinical
promotion system
– EBP mentors
– Infrastructure that provides tools to enhance EBP
– Administrative support and leadership that value EBP
– Recognition Programs
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Step #1 - Formulate an Answerable Question
1. The most critical step is to identify a
focused clinical question.
2. What do you need to ask a focused research
question?
What is the population?
What is the treatment of choice?
How do the treatments compare?
What is the result of the treatment?
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PICOT Question
P - Patient population of interest
I - Intervention of interest
C - Comparison of interest
O - Outcome of interest
T – Time frame
Melnyk & Fineout-Overholt, 2002
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Example of a PICOT Question
P: In hospital patients with indwelling foley catheters,
I: how does silver alloy coated catheters
C: as compared to non-silver coated catheters
O: affect the incidence of CAUTI
T: during the acute care hospitlaization period?
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Step #2 - Search for Best Evidence
• Question
• Database
• Determine the type of study design that best answers the question
• Search – subject heading, key words, combination
• Set Limits – yr, language, human, type of study
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Places for Best Evidence
• National Guideline Clearinghouse
• Cochrane Center and Collaboration (Systematic
Reviews)
• Joanna Briggs
• Agency for Healthcare Research and Quality
• Electronic Data bases and Ovid software
• Medline , CINAHL, Psych info
• Specialty organizations
• AACN, AORN, EAST, ONS, STTI
• www.nursinglibrary.org
• Internet EBP sites
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Examples of AHRQ Practice Guidelines
• Pain management
• Decubiti prediction/prevention
• Cataract treatment in adults
• Depression treatment
• Screening, diagnosis, management of sickle cell disease in newborns and infants
• Otitis media treatment in children
• Availability of cardiac rehabilitation services
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How do I know I have all the evidence?
• There is no magic number!
• Look for repeating references– Carefully capture the databases searched & search
strategies
– Remember different data bases index differently and may require different strategies.
• It is called saturation!
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Step # 3 - Critical Appraisal of Evidence
• Evaluate and appraise the evidence for validity and usefulness
• The Most Important Step!!!!!
– Tools to critique the study; look at all parts of the research study from start to finish
– Tools (nomenclature/Taxonomy) to classify the literature• US and Canadian Preventative Services Task Force
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Critical Appraisal cont’d
• Are the results of the study valid (Validity)?– close to truth – best research methods possible?
• What are the results (Reliability)?– Intervention worked?
– Treatment effect?
– Similar results in own practice setting?
• Will the results help me in caring for my patients (Applicability)?– Subjects are similar to pts
– Benefits are greater than the risks
– Treatment is feasible
– Patient desires the treatment
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Levels of Evidence Pyramid
pyramid modified from: Navigating the Maze, University of Virginia, Health Sciences
Library
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Synthesis of Research Findings
• Knowledge comes from quantitative, qualitative, and outcomes research
• Content clustering: integration of findings from scientifically sound research to determine what is currently known or not known– Accomplished through:
• Integrative reviews• Systematic reviews• Meta-analyses, metasummaries,
metasyntheses
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Continuum of Strength of Research Evidence
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Critical Appraisal cont’d
• Is there a sufficient research base??
– Adequate amount of studies
– Appropriate methods
• Sample size
• Design
• Results
– Feasible
– Risks / benefits assessed
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Critical Appraisal cont’d
• Research base is sufficient --
• Pilot findings in practice
– Clarify the outcomes
– Design nursing / multidisciplinary guidelines
– Implement on “pilot” unit
– Evaluate process and outcomes
– Modify, if necessary, the practice change
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Critical Appraisal cont’d
• Research base is insufficient --
• Conduct research
• Consider basing practice on other types of evidence
– Case reports
– Expert opinion
– Scientific principles / theory
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Step # 4 - Integrate the Evidence into Practice
• Combine evidence with healthcare provider’s expertise and patient preferences and values to make a decision.
• Is the project feasible??– Resources, large enough volume, equipment
– Cost/Benefit Analyses
• Develop an Action Plan– Identify setting
– Identify structure or process components that need to be revised
– Education
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Step # 5 - Evaluate Effectiveness
• It is a critical step to evaluate success of the practice change.
– Monitor correct utilization of practice
– After the change is done, the outcomes must be monitored for effectiveness
– Change should be documented for improved quality of care, decreased costs, saved nursing time, improved access to care
• Monitor fiscal outcomes
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Evaluation cont’d
• Is Change Appropriate for Adoption in practice??
– ? Cost effective
– ? Improve quality
– ? Competent staff
– Change champions available??
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Evaluation cont’d
• Change practice
– Communicate to all involved
– Empower staff
• Key decision makers -- how to introduce change and educate others
• Right tools -- Know scientific rationale
– Monitor outcomes
• Establish timeline
• Assess quality and fiscal
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Step # 6 - Disseminate the Outcomes
• If it is not published – it is not done.
• Remember that “Ivory Tower” research!
• The Three P’s!
– Poster
– Publish
– Present
• University of Texas - EBP Institute
• U of Arizona
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“Bridging the Gap”
• Transforming the evidence into relevant practice changes is difficult!
• Making the practice changes operational in the “real world” is tough!
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Barriers and Facilitators to the Utilization of Nursing Research
• Carrol et al, 1997
• “What do nurses perceive to be the barriers to using research in practice?”
• “What do nurses perceive to be the facilitators to using research in practice?”
• 1100 nurses surveyed, 356 responded (30%)
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Barriers to EBP
• Individual nurse– Unaware of the research / findings
– Isolated from knowledgeable colleagues with whom to discuss research
– Lack of belief that EBP will result in positive outcomes
– Peer pressure to continue with practices that are steeped in tradition
– Demands from patients for a certain treatment
– Communication
– Research reports are not readily available and in an understandable format
– Voluminous amount of information
• Organization– Insufficient time on the job to implement new ideas or read research– No authority to change patient care– Other staff are not supportive and resistant to change– Lack of EBP mentors
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Successful Facilitators
• Create a climate in which research is expected and valued – Promote a Spirit of Inquiry
– Job description
– Clinical ladder
– Merit system
– Time allotment
• Establish mechanisms whereby research skills can be acquired and applied
– Orientation
– Formal Programs
– Informal Programs
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Facilitators cont’d
• Develop an infrastructure for the provision of guidance, resources, advise
– Administrative support
– EBP Mentors
– NRC
– Clear mission and EBP Model – Univ of Iowa
• Improve research reports
– Availability
– Accessibility
– Understandability
• Forces of Magnetism
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Challenges of the Real World
• Miller et al. (1997) described challenges of the real world
– Organizational restructuring
– Climate of uncertainty
– Economic constraints
• Strategies
– Clearly articulate the purpose
– Look for resources
– Listen to and respect the staff’s concerns and workload
– Know the climate and be ready to make accommodations
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So, how do we really get rid of these sacred cows?
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Time has come to embrace EBP and move from practices that are
steeped in tradition or based on outdated policies!!
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Strategies
• Ask clinicians about their knowledge and belief of EBP.
– It is critical for providers to believe that EBP will produce better outcomes (Melnyk et al., 2008).
• Correct misperceptions.
– Clarifying perceptions and teaching EBP is critical for the advancement of EBP practices.
• Never stop asking questions!
– Promote that culture of inquiry.
– Reward inquisitiveness.
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Exemplary Models
• University of Iowa
• University of Arizona
• University of Michigan
• John Hopkin’s University
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What can YOU do???• Be a change agent...
organizational champion .... evidenced-based guru...healthcare hero!!!
• Be a role model of professional behavior and evidenced-based practice
• Be creative and innovative in shaping a new system --move out of the comfort zone!
• Inspire and challenge others to perform their best!
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Knowing is not enough; We must apply. Willing is not
enough; We must do.Goethe
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Research Day
2010
Linda Matula Schwartz, MDEInformation Specialist
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Select topic Define question Create query Search literature Document search strategy Review abstracts Screen articles using inclusion/exclusion criteria Obtain/review full text articles Identify relevant articles Determine data needed from each article Assess quality of each article Construct evidence table Synthesize evidence – statistical analysis Summarize evidence – visually and/or text
Search & Summarization Process
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Databases and internet are both helpful Know their strengths and weaknessesKnow how to use them
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• Textword searching is the norm when searching the web because websites are indexed using WORDS.
• Bibliographic databases use medical subject headings (MESH) because articles are indexed using SUBJECTS which are more comprehensive. Textword searching is a secondary approach for refinement.
Textword vs Structured Language
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• Selected literature • Methods to limit by age, gender, type of research study
(publication types) and care setting • More access to full text • Can suggest appropriate subject headings/related subjects
through thesaurus and subject hierarchies (trees)• Includes synonyms• Subheadings to narrow topics• Bibliography creation• Shareable with teams • Capture search history• Save/rerun searches• May format citations• Added textwords/phrases can increase relevance or find very
specific info
Databases
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• Only 10% of web info searchable by search engines • Good for open source articles not found in databases• Google Scholar better than Google • Older info presented first – can you work around it?• Beware! Personalized search• Some access to full text • “Cited by” information• Full text reports (not articles) – advanced search!• No comprehensive searching of nursing articles• Search with phrases (most specific) and textwords• YOU have to include synonyms/related concepts • Good for new topics• LOTS of articles/info but grouped by POPULARITY not
relevance
Internet
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Evidence-Based
Research:
Creating
Answerable
Clinical Questions
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Why care about the question?
• Save time when searching
• Suggest appropriate subject terms and keywords
• Keep the search manageable
• Suggest the type of research studies (publication
types) needed
A well chosen question will:
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Methods for Focusing Questions
• Distinguish between disease oriented and patient oriented questions
• Distinguish between point of care questions and research questions
• Use the PICO method to focus patient oriented research questions
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Using PICO to Focus Questions:
P = Patient/Problem/Population
• What are the patient characteristics?
• How would you describe a group with a similar problem?
• What is the chief complaint or problem? (etiology questions)
• What is the disease status?
• Consider age, race, gender, comorbidity, current meds, clinical setting
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Use PICO to Focus Questions:
I= Intervention
• What is planned for the patient?
• May be a medication, surgery, treatment, diagnostic test, behavioral intervention, prognostic factor, causative agent or exposure
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Use PICO to Focus Questions:
C= Comparison
• What will the intervention be compared to?
• May be the standard of care or an alternative medication, treatment, surgery, diagnostic test, prognostic factor, behavioral intervention
• Alternative may be placebo or no treatment
• There may not be a comparison– New therapeutic approach
– Not ethical to randomize
• For best searching, limit comparison to one alternative choice
• Don’t try to search for superlatives!
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Use PICO to Focus Questions:
O= Outcome
• What should the results of the intervention be?
• May include relief/elimination of symptoms, improvement in function or disease state, better quality of life, confirmation of diagnosis, reduced mortality/morbidity, timely diagnosis
• Consider both HCP and patient perspectives
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PICOT (Variation of PICO) T= Type of Question / Time
• Time – can really mean setting (during ICU stay) or actual time (for life, during adolescence – part of P)
• TYPE of question
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Question Type Determines Appropriate Research Type
Systematic Reviews & Meta-analyses are appropriate for all question types.
Question Type Type of Research (Publication Type)
Therapy Randomized Controlled Trial (RCT)
Prevention RCT – Cohort Study – Case Control
Diagnosis RCT – Cohort Study
Prognosis Cohort Study – Case Control – Case Series – Case Report
Etiology/Harm RCT – Cohort Study – Case Control
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Evidence Pyramid
Increasing
Scientific
Rigor &
Relevence
Decreasing
Volume of
Literature
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USE the question to select search terms / textwordsOR together synonyms
IN children taking antibiotics WILL probiotics COMPARED TO
nothing or placebo RESULT IN decreased antibiotic associated
diarrhea?
Children = Age Limiter
Antibiotics = Anti-Bacterial Agents (MESH) ORAnti-Infective Agents (MESH)
(If specific antibiotic, use that term instead)
Probiotics = Probiotics (MESH) OR Lactobacillus (MESH) ORYogurt (MESH)
Placebo = Placebos (MESH)
Antibiotic Associated Diarrhea = Diarrhea (MESH)
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• The question type to select
the publication type
• The publication types to find
higher levels of evidence.
Use
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Create a focused clinical question
You are an RN working in a family practice setting. Mr. Adams,
a 54 yo carpenter from India, has been being seen for the past
6 months for mild hypertension (~130/90), persistent
hyperlipidemia with LDL of 190 and mild hyperkalmia (5.9 mM
potassium). He is taking Quinapril 10 mg, Lovastatin 10 mg
and Warfarin 2 to 4 mg daily depending on PT/INR following
an episide of DVT. He mentions that he is now drinking
turmeric tea 4x/day to reduce his cholesterol level. You have
not heard of this practice and decide to search the literature
for information on efficacy and potential interactions with his
medications.
IN (patient/population)
WILL (intervention)
COMPARED TO (comparison)
RESULT IN (outcome)
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Use the focused question to
guide the selection of search terms.
A focused clinical question
is the first step to finding
good research evidence.
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Evidence-Based
Practice:
Searching
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At a minimum:–Medline
–CINAHL
–Cochrane Library
–AHRQ Evidence Reports
–National Guidelines Clearinghouse
–Specialty organization
–Google Scholar
What tools do I search?
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• Don’t be “satisficed” It is a natural cognitive tendency to want to stop searching as soon as something is found.
• Evidence based practicerevolves around improvementNOT verification (confirmation bias).
Searching Traps to Avoid
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• Know the difference between primary and secondary sources. http://edmgr.ovid.com/ajn/accounts/PrimaryandSecondarySourcesGuidelines.doc
• UNACCEPTABLE secondary sources for publications: – Website stats without a source
– Citation within a citation
– Press/newspaper releases
– Textbooks
– Systematic reviews or meta-analysis for evidence are good for conclusions from the overall review but cannot use info from mentioned studies – get the original research
Other Traps to Avoid
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• “Limiting literature reviews to an arbitrary number of years sometimes wrongly suggests that the best work on the issue occurred recently”* (the often assigned “last 3-5 years” search)
• Don’t forget to check the background (disease-oriented) information if needed
Other Traps to Avoid
*Editorial: Consider the Source. Mason, DJ. AJN 4/09; 109(4):7.
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• Limit the search
• Identify unwanted concepts and eliminate them
• Use subject headings or phrases instead of textwords
• Look for more specific subject headings
• Limit the date range IF APPROPRIATE
• Limit by language, age, publication type
What if I find too much?
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At LVHN, call 610-402-8410
What if I STILL don’t find anything?
Librarians make great consultants!
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Evidence
Tables
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• Identify key data
• Extract data from relevant articles
• Organize collected data to aid comparisons among studies
• Analyze and indicate an evidence level
• Incorporate commentary from the analysis
Why an Evidence Table?
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EBSCO OVID
PubMed – Advanced Search Screen
Harvesting the Search Strategy
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Brief description including
• Database name e.g. MEDLINE• Database search system e.g. EBSCOHost, OVID, PubMed• Date search was done• Years searched• Search strategy as an appendix or, at minimum, description
of the search and terms used.
Documenting the Search Strategy
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Example: MEDLINE was searched using the EBSCOHost interface on 12/21/2010 for the period 1996 to 12/2010. Search strategy is reproduced in Appendix A.
Example: On 12/21/2010, the following databases were searched for relevant studies:MEDLINE via PubMed for 1990 to 5/2010; CINAHL via EBSCOHost for1990 to 12/2010. The search strategy included medical subject headings(MESH) and keywords relating to: clinical decision support (MESH), decisionmaking, computer assisted (MESH), diagnosis, differential (MESH) and
diagnos* (keyword). Articles were limited to English, and human wherepossible. A search was also conducted of the internet using Google Scholar.Phrase searching included: “clinical decision support”, “differentialdiagnosis”, “differential diagnosis generator” and keyword searching:software OR program OR programs OR system OR systems. Furtherarticles were identified by examining the reference lists of articles.
Documenting the Search Strategy
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http://www.americanheart.org/downloadable/heart/1259165870696EIT-002A%2013-Sep-2009.pdf
Documenting the Search Strategy
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Fathimani, K, et al. Diagnosis, Risk Factors and Management of Dental Erosion: An Evidence Based Report.
http://www.utoronto.ca/dentistry/newsresources/evidence_based/DiagnosisRiskFactorsAndManagementOfDentalErosion.pdf
Document rejected articles
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Citation
Study type
Reference Number
Population (Location, age, sex, disease status, gender, etc.)
Study objective /hypothesis
Intervention (Description, setting, provider, frequency, duration, funder)
Outcome Measures
Limitations Results Comments Critical AppraisalLevel of Evidence
Study 1
Study 2
Create table format from data or use template from publisher
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Questions?
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Critiquing EvidencePart 3
Carolyn L. DavidsonPhD, RN, CCRN, APRN
Director Nursing Quality and EBP
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OBJECTIVES
Discuss the purpose, evolution and importance of EBP
Develop a searchable practice question
Appraise the evidence for application to clinical practice.
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HANDOUTS
Critical Appraisal Tool
Articles o Hull (2010);
o Leaberry (2010);
o Tzeng (2010))
Evidence Rating Scale
Evidence Table
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The “HOW” with “WHAT”
Hierarchy – Levels of Evidence
+
Quality of Evidence
=
Strength of Evidence
CRITICAL APPRAISAL
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Describes different
hierarchies for
assessing scientific
evidence for clinical
recommendations
HIERARCHY
EVIDENCE LEVEL
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EVIDENCE HIERACHY
Oxford Centre (I – V with sublevels, therapy-prognosis, intervention)
AHRQ (A – D, I and Good, Fair, Poor)
SORT (A – C, Level 1 – 3)
GRADE (High to low quality)
Melnyk and Fineout-Overholt (I – VII)
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www.agreecollaboration.org
AGREE Instrument : 6 Domains
Scope & Purpose
Stakeholder Involvement
Rigor of Development
Clarity & Presentation
Applicability
Editorial Independence
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STRENGTH
QUALITY: internal validity (bias,
confounding variables)
QUANTITY: number of studies, sample
sizes, magnitude of treatment effect
CONSISTENCY: do the multiple studies
have similar or differing designs
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Meta-Analysis
The statistical analysis of a large collection
of analysis results for the purpose of
integrating the findings.
Provides the same methodological rigor to
a literature review that is required from
experimental research.
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Systematic Reviews
A compilation of similar studies
Comprehensive search strategy and rigorous appraisal methodology
Serve to summarize, appraise and communicate results and implications
SR’s are effective at minimizing bias
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Aspirin for the Prevention of Cardiovascular Disease (Leaberry, 2010)
Article review (handouts)
Evidence assignment
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• In adults, what is the effect of aspirin in the prevention of cardiovascular events?
Research Question
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Search Strategy
Prevention of CV
Disease
Adults ASA CV EVENTSPREVENTION
Peer Reviewed, clinical trials, MA, EBP
7953
79815
Exclude multi-meds or health issues
10
NGCCINAHL
PUB MEDCOCHRANE
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SYNTHESIS
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Interpretative integration of qualitative findings in primary research
Metasynthesis
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RCT (Randomized Control Trial)
Experiment that involves an intervention with random assignment of participants to control or experimental groups
RCT’s answer question about efficacy and effectiveness
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Non-RCT’s (Cohort, Case, Descriptive)
Cohort: longitudinal study with an intervention group
and a control group to measure development of X over time
Case: describes history of a sing patient or group of
patients
Case control: retrospectively compares
characteristics of an individual who has a condition against a control
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What to do with the findings?
http://www.youtube.com/watch?v=CRTc6Vm3rXY
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Elements of the Evidence
Title
Abstract
Introduction/Background
Literature Review
Methods
Results
Discussion
Conclusion
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ARTICLES
Impact of medication storage cabinets on efficient delivery of medication and employee frustration (Hull, Czirr, Wilson, 2010)
Inpatient falls in adult acute care setting: Influence of patients’ mental status (Tzeng, 2010)
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TITLE
Informative
Assist reader to understand what type of study is being reported
o What was done
o To whom was it done
o How was it done
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ABSTRACT
Study purpose/aim
Methods
Results
Conclusions
Clinical relevance
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INTRODUCTION
Background
o Literature review
o Author identifies knowledge gap between what is known and what study seeks
Problem statement/Aim/Purpose
Research Question/Hypotheses
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Supporting Mechanism Literature review—
o Is there a thorough thought process
o Articles from peer-reviewed journals
o Limiting prior publications from the primary or contributing authors of current article
o Literature supports need to conduct further research-problem or gap as identified in the aims
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VARIABLES
Independent (predictor) /dependent (outcome)
o Definitions
o Measurement
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Aims/Purpose/Objectives
How is it stated?
o Clear
• Research question
Singular
Plural
o Hypotheses
Null
Alternate
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METHODS
Interventions
o Clearly described
Study population
o Inclusion/exclusion criteria
o Recruitment
o Demographic characteristics
Instrumentation
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STUDY POPULATION
Sample (N or n)
o Homogeneous/heterogenous
o Measures of central tendency
Mean (M or X, ), median, mode
o Variability
Standard deviation (SD, ), range
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STUDY POPULATION -con’t
Sample
o Representativeness
o Response rate
Less must be considered as a potential limitation/bias--responders being different from non-responders
o External validity-generalizations
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POWER of SAMPLE
Power
oEnough subjects to demonstrate statistical significance
oRoughly—a minimum of 15 per variable
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INSTRUMENTS
Psychometric properties
oValid—actually can measure construct
oReliable—consistency
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INSTRUMENTATION
QUESTIONS:o Does the instrument answer the research questions?
o Reflective of the variables-subscales
o Construction
o Population similarity
o Interpretation of scores (may need to look at original work—subscales vs. instrument
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RESULTS
Research design appropriate to questions
oDescriptive
oRelational
oCausal
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CAUSE and EFFECT
Statistics is mostly moving on the surface of phenomena…
e.g. counting occurrences
Hence, it is unlikely that statistics can decide causality except under experimental circumstances, like randomized trials
However, statistics may give an important contribution to understanding causality
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RESULTS
List the findings of the data analysis
o Should not contain commentary
Figures and tables
Statistical vs. clinical significance
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DISCUSSION/CONCLUSIONS
The results are tied to the introduction
o Cross-examination of past literature with new findings
Vague expressions
o Overstating findings (general belief…)
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LET’S PUT THIS INTO ACTION
TITLE ABSTRACT INTRODUCTION LITERATURE VARIABLES AIMS/OBJECTIVES
METHODS POPULATION INSTRUMENTS RESULTS CONCLUSION
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TITLE Impact of medication storage cabinets on efficient
delivery of medication and employee frustration.Hull, Czirr, Wilson (2010)
Inpatient falls in adult acute care settings: Influence of patients’ mental status. Tzeng (2010)
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APPRAISAL EXERCISE
GROUP 1: Title, Abstract, Purpose/Aims
GROUP 2: Intro/background, Literature Review
GROUP 3: Methods (Population, setting, Instruments)
GROUP 4: Results, conclusion, discussion
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ABSTRACT
Background
Methods
Results/Findings
Conclusion
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INTRODUCTION
Does it support the reasoning for doing the study?
Falls: Lack of consistent evidence for preventative interventions-important to determine prevalence of falls in which fallers MSD’s were documented as an issue
Medication: global concerns about safety to examine changes in workflow. After an FMEA on med processes in PCU
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LITERATURE
What is it telling us?
Falls: CMS and no payment, definition, reasons for falls, where falls occurred, relationship of MSD’s to admission and future risks
Medication: safe administration of meds, innovations, limiting distractions, placement of meds
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VARIABLES
What are they?
Falls: Fall incidents associated with MSD’s, level of injury, site of fall
Defined/Operationalized?
Fall was defined; injury was not defined only labeled as 1-4)
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VARIABLES
What are they?
Meds: nurses steps, PYXIS trips, nursing frustration, pharmacy workflow
Defined/Operationalized?
Meds: steps/shift with pedometer; Nurse daily log (number of steps, level of frustration, 0-100 VAS; room assignments, PYXIS access-# times, waiting for PYXIS, Pharm communication for missing meds, # times); Pharm Tech Daily Log (time in min to deliver meds, location, number of med cabinets stocked, feedback on delivery process (0-100) VAS
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AIMS/OBJECTIVES
What are the aims/objectives?
Falls: Determine prevalence of falls where the fallers MSD was dominant issue
Meds: efficiency to store meds in cabinets v. Pyxis, level of nurse frustration w/process
Are they clearly stated? Yes
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METHODS
Questionnaires reflect measures of the variables? What are the questionnaires? Are they valid/reliable?
FALLS:
Prior study with themes, interrater reliability of data abstraction not discussed
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METHODS
Questionnaires reflect measures of the variables? What are the questionnaires? Are they valid/reliable?
MEDS:
Logs, VAS scales post installation-Likert scale of feedback on cabinets
? LOGS and validation of completion, no stats on the Likert scale
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POPULATION/SAMPLE
Can you clearly determine inclusion and exclusion criteria?
FALLS: Falls in the system with dates
MEDS: Nurses on PCU and pharmacy techs
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INSTRUMENTS
Instrument with validity and reliability? Discussed findings as they related to the instrument psychometrics?
FALLS: as previously discussed, not sure about themes and interrater reliability; also highly dependent on nurses entering info correctly
MEDS: Likert scale-no validity and reliability
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RESULTS
Can you relate to the results? Do they seem reasonable? Type of statistics and what was tested; Additional qualitative comments
FALLS: Use of tables, theme of fall incidents, falls with MSD’s, statistical use of Pearson Chi-Square (categorical data); severity of fall and association with MSD
Additionally included info about age groups
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RESULTS
Can you relate to the results? Do they seem reasonable? Type of statistics and what was tested; Additional qualitative comments
MEDS: Nurse participants, results on pedometer, accessing meds (med missing increased as did the steps, but NS.
Frustration-higher after cabinets installed
Pharmacy times increased, frustration increased
Discussion from nurses about missing meds
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CONCLUSION
What was the conclusion? Does the discussion tie back to the original purpose/aim and the gaps identified in the literature?
FALLS: shortcoming of form, RN perception, lack of standardized mental status form
MEDS: Many changes occurring concurrently created problems with data, used focus groups to follow-up.
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Study Soundness (Validity and Reliability)
Evidence-based practice is about improving not verifying/confirming your beliefs.
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Significance vs. Real Significance
Consider results within context of practice
**Research utilization is changing practice with one study
v.**EBP is changing practice
based on multiple studies where available
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News Flash
Reporting from Research studio:
Research inherently has flaws in how it is designed, conducted or reported!
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Why Emphasis on ‘best practice’ has shifted from
keeping current through traditional continuing education to ….
Keeping current with the latest and best available evidence that has been critically appraised for quality and impact…predict outcomes.
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What is means for you?
Everyday, every time, every patient should be the beneficiary of your hard work, diligence to discover sound and best practices.
Clinical inquiry leads to sound practices that are embedded in the
clinical policies and procedures.
Don’t be a “Betty Lou”
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Internal Evidence
Internal evidence:o Outcomes management
o Quality improvement
o EBP implementation projects
Role of internal evidence:o Improve clinical practice and patient outcomes within
local setting
o Survey own system and compare to benchmark
Systems of internal evidence:o AHRQ, NQF, NDNQI
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Putting it all Together
Evidence summary
o Statement(s) that describe your search strategy, the keywords, how many studies were located, how many were used, why some studies excluded, methods of appraisal, and a synthesis of findings that will support the practice.
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Applications
Past:
o Clinical actions based solely on logic, tradition, or conclusions drawn from observation-result in bias
o Variations in practices across caregivers and settings-result is unreliable patient outcomes
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Take it home…
Basic principle is that you don’t make
decisions because they are easy; you don’t
make them because they are cheap; you
don’t make them because they’re popular;
you make them because they’re right”Fr. Theodore Hesburgh
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CHECKPOINT:State of Mind?
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