patient jl 2103 (drug study)

Alnix® [film-coated tab]

Westmont [ Westmont ]

MIMS Class : Antihistamines & Antiallergics

See related Alnix film-coated tab information

Contents Cetirizine diHCl

Indications Sympomatic relief of allergic rhinitis eg sneezing, runny & itchy

nose, watery eyes; allergic conjunctivitis; skin symptoms of allergy

eg itch & rash.

Dosage Tab Adult & childn >12 yr 1 tab once daily. Childn 6-12 yr ½ tab

bid or 1 tab once daily. Syrup Childn 6-12 yr 10 mL (2 tsp) once

daily or 5 mL (1 tsp) bid, 2-5 yr 5 mL (1 tsp) once daily or 2.5 mL

(½ tsp) bid. Oral drops Childn 2-5 yr 2 mL once daily or 1 mL bid,

12 mth-<2 yr 1 mL once or bid. Infants 6 mth-<12 mth 1 mL

once daily.

Overdosage View Alnix overdosage for action to be taken in the event of an

overdose.

Administration May be taken with or without food

Contraindications [Click For Detailed Information]

Special Precautions

May cause drowsiness and may affect ability to drive/operate

machines. Patients w/ kidney or liver disease.

Adverse Drug Reactions

Drowsiness/sleepiness, sore throat, headache, nausea. Adult &

childn >12 yr: Excessive tiredness, dry mouth, dizziness. Childn 6-

11 yr: Stomach pain, cough, diarrhea, bronchospasm, epistaxis,

vomiting.

View ADR Monitoring Website

Drug Interactions Alcohol, drugs for anxiety or sleep disorder (alprazolam,

diazepam, chlordiazepoxide, temazepam & triazolam),

antidepressants (amitriptylline, doxepin, nortriptylline, fluoxetine,

sertraline, paroxetine), other cold or allergy medicines.

http://www.mims.com/Page.aspx?menuid=mng&name=Alnix+film-coated+tab&brief=false&CTRY=PH

http://www.mims.com/Page.aspx?menuid=cd&mode=CPI&name=Westmont&CTRY=PH

View more drug interactions with Alnix

Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not

demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Storage View Alnix storage conditions for details to ensure optimal shelf-

life.

Mechanism of Action

View Alnix mechanism of action for pharmacodynamics and

pharmacokinetics details.

MIMS Class Antihistamines & Antiallergics

ATC Classification

R06AE07 - Cetirizine ; Belongs to the class of piperazine

derivatives used as systemic antihistamines.

Poison Schedule film-coated tab:Non-Rx; syr/drops:Rx

Sibelium® [cap]

Janssen [ Zuellig ]

MIMS Class : Antimigraine Preparations

See related Sibelium cap information

Contents Flunarizine

Indications Prophylaxis of classic (w/ aura) or common (w/o aura) migraine.

Symptomatic treatment of vestibular vertigo due to a diagnosed

functional disorder of the vestibular system.

Dosage Migraine Prophylaxis: Starting dose: Patient <65 yr 10 mg at

night, >65 yr 5 mg at night. Maintenance: If patient is responding

satisfactorily & if a maintenance treatment is needed, decrease

dose to 5 days treatment at the same daily dose w/ 2 successive

drug-free days every wk. Vertigo Same daily doses as for

migraine, but starting treatment should not be given longer than

needed for symptom control, which generally takes <2 mth.


Contraindications Patients w/ a history of depressive illness; preexisting symptoms

of Parkinson's disease or other extrapyramidal disorders. Driving

or operating machinery.

Special Precautions

Elderly. Pregnancy, lactation.


Frequent: Drowsiness &/or fatigue, wt gain, depression,

extrapyramidal symptoms. Rare: Heartburn, nausea, gastralgia,

insomnia, anxiety, galactorrhea, dry mouth, muscle pain & skin

rash.


Drug Interactions Alcohol, hypnotics or tranquilizers & β-blockers.

View more drug interactions with Sibelium

MIMS Class Antimigraine Preparations

ATC Classification

N07CA03 - Flunarizine ; Belongs to the class of antivertigo

preparations.

Poison Schedule Rx

Presentation/Packing

Iselpin® [tab]

Wyeth [ Metro Drug ]

MIMS Class : Antacids, Antireflux Agents & Antiulcerants

See related Iselpin tab information

Contents Sucralfate

Indications Duodenal & gastric ulcers, chronic gastritis.

Dosage Adult 1 g qid.

Administration Should be taken on an empty stomach (Take on an empty

http://www.mims.com/Page.aspx?menuid=cd&mode=CPI&name=Wyeth&CTRY=PH

stomach 1 hr before or 2 hr after meals, & at bedtime.).

Contraindications Patients on dialysis.


Constipation, diarrhea, nausea, GI discomfort, indigestion; dry

mouth; rash, pruritus; back pain; dizziness, drowsiness & vertigo.


Drug Interactions May inhibit absorption of ciprofloxacin HCl, norfloxacin & other

new quinolones.

View more drug interactions with Iselpin



MIMS Class Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02BX02 - Sucralfate ; Belongs to the class of other drugs used in

the treatment of peptic ulcer and gastro-oesophageal reflux

disease (GERD).

Poison Schedule Rx


Randin® [amp]

Pasteur Pharma [ Scheeling Pharma Care Link / Deutsche Lab ]

MIMS Class : Antacids, Antireflux Agents & Antiulcerants

See related Randin amp information

Contents Ranitidine HCl

Indications Gastric & duodenal ulcer, Zollinger-Ellison syndrome, reflux

esophagitis, post-op ulcer, hemorrhage of upper GIT in peptic

ulcer, acute stress ulcer & acute gastric mucosal disease.

Dosage IV Adult 50 mg slow inj diluted to 20 mL for 2 min, may be

repeated 6-8 hrly, intermittent IV infusion at 25 mg/hr for 2 hr

repeated 6-8 hrly. IM 50 mg 6-8 hrly. Prophylaxis of upper GI

hemorrhage from stress ulcer Prime dose of 50 mg slow IV

followed by continuous IV infusion of 0.125-0.25 mg/kg/hr.

Mendelson's syndrome 50 mg IM/IV 45-60 min before general

anesth. Renal impairment 25 mg.

Contraindications Hypersensitivity.

Special Precautions

Gastric carcinoma, renal & hepatic impairment, history of acute

porphyria. Pregnancy & lactation. Childn.


Changes in liver function tests, hepatitis, blood count changes.


Drug Interactions Diazepam, lignocaine, phenytoin, propanolol, theophylline &

warfarin.

View more drug interactions with Randin



MIMS Class Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02BA02 - Ranitidine ; Belongs to the class of H2-receptor

antagonists. Used in the treatment of peptic ulcer and gastro-

oesophageal reflux disease (GERD).

Poison Schedule Rx


Lorid® [tab]

Unique [ Ambica ]

MIMS Class : Antihistamines & Antiallergics

See related Lorid tab information

Contents Loratadine

Indications Symptomatic relief of allergic conditions including rhinitis & chronic

urticaria.

Dosage Tab Adult 1 tab once daily. Syr Childn 6-12 yr, 2-12 yr (>30 kg) 2

tsp once daily, 2-12 yr (<30 kg), 2-5 yr 1 tsp once daily. Hepatic

or renal impairment Initially 1 tab on alternate days.

Overdosage View Lorid overdosage for action to be taken in the event of an

overdose.



Special Precautions

Pregnancy & lactation.



Storage View Lorid storage conditions for details to ensure optimal shelf-

life.

Mechanism of Action

View Lorid mechanism of action for pharmacodynamics and


MIMS Class Antihistamines & Antiallergics

ATC Classification

R06AX13 - Loratadine ; Belongs to the class of other

antihistamines for systemic use.

Poison Schedule Rx


Essential Prescribing Information

Furide® [amp]

Duopharma (M) Sdn Bhd [ International Apex ]

MIMS Class : Diuretics

See related Furide amp information

Contents Furosemide

Indications Treatment of edema associated w/ CHF, cirrhosis of the liver &

renal disease including nephrotic syndrome. IV Acute pulmonary

edema.

Dosage Adult Initially 20-40 mg IM/IV as single dose. Acute pulmonary

edema 40 mg slow IV followed by another 40 mg dose 1-1½ hr

later. Infants & childn Initially 1 mg/kg IM/IV, may be increased

by 1 mg/kg ≥2 hr after the previous dose.

Contraindications Anuria, hepatic coma & electrolyte deficiency. Pregnancy.

Special Precautions

Severely impaired renal function. Diabetes.


Dermatitis including urticaria. Anemia, leukopenia, aplastic anemia

& thrombocytopenia. Tinnitus & reversible hearing impairment.

Furosemide-induced diuresis accompanied by weakness, fatigue,

lightheadedness or dizziness, muscle cramps, thirst, increased

perspiration, urinary bladder spasm & symptoms of urinary

frequency. Transient pain at inj site after IM inj.


Drug Interactions Potentiation of hypotensive or diuretic effect of antihypertensives

or alcohol. Amiodarone, amphotericin B, anticoagulant, NSAIDs,

lithium, chloralhydrate, probenecid.

View more drug interactions with Furide

Pregnancy Category (US FDA)

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

if used in gestational HTN.

Category D: There is positive evidence of human foetal risk, but

the benefits from use in pregnant women may be acceptable

despite the risk (e.g., if the drug is needed in a life-threatening

situation or for a serious disease for which safer drugs cannot be

used or are ineffective).

MIMS Class Diuretics

ATC Classification

C03CA01 - Furosemide ; Belongs to the class of high-ceiling

sulfonamide diuretics.

Poison Schedule Rx


Strumazol® [tab]

Organon [ Zuellig ]

MIMS Class : Antithyroid Agents

See related Strumazol tab information

Contents Thiamazole

Indications Mild to severe hyperthyroidism, treatment of Grave's disease, prep

of hyperthyroid patients for thyroidectomy & use as an adjunct to

radioactive iodine therapy.

Dosage Monotherapy Titrate according to hormone levels. Combination

therapy w/ thyroid gland hormone replacement Start w/ 30

mg/day. If euthyroidism is involved, add synthetic levothyroxine

after approx 6 wk.

Administration Should be taken with food (Take after meals.).

Contraindications Proven hypersensitivity to thiamazole & carbimazole;

agranulocytosis during previous treatment w/ thiamazole,

carbimazole or PTU (in connection w/ the cross-hypersensitivity).

Special Precautions

Pregnancy & lactation.


Fever, arthralgia, arthritis, rashes, leukopenia, agranulocytosis,

hepatotoxicity, vasculitis, LE (lupus erythematosus) syndrome,

aplastic anemia, thrombocytopenia, nephrotic syndrome, loss of

the sense of taste.


Drug Interactions As Strumazol leads to a change in the metabolism, it may be

necessary to adjust the dosage of other drugs.

View more drug interactions with Strumazol

Pregnancy Category (US FDA) Category D: There is positive evidence of human foetal risk, but

the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

MIMS Class Antithyroid Agents

ATC Classification

H03BB02 - Thiamazole ; Belongs to the class of sulfur-containing

imidazole derivative agents. Used in the management of thyroid

diseases.

Poison Schedule Rx


Essential Prescribing Information

Aero-Vent® [nebules]

Cipla [ Phil Pharmawealth ]

MIMS Class : Antiasthmatic & COPD Preparations

See related Aero-Vent nebules information

Contents Salbutamol sulfate

Indications Treatment of acute severe asthma & in routine management of

chronic bronchospasm unresponsive to conventional therapy.

Dosage Adult & childn 2.5-5 mg. May repeat qid by nebuliser. Delivery of

aerosol may be by face mask of "T" piece. Use undiluted. For

prolonged delivery time, dilute w/ sterile water or normal saline for

inj.

Overdosage View Aero-Vent overdosage for action to be taken in the event of

an overdose.


Special Precautions

Hyperthyroidism, thyrotoxicosis, CV diseases eg ischemic heart

disease, arrhythmia/tachycardia. Occlusive vascular disorders eg

arteriosclerosis, HTN, aneurysms. Angina pectoris, DM, closed-

angle glaucoma.


Small increase in heart rate, peripheral vasodilation, fine tremor of

skeletal muscle.


Side Effects View Aero-Vent side effects

Drug Interactions Cyclopropane, halothane, other halogenated anesthetics. Cardiac

glycosides, quinidine, tricyclic antidepressants.

View more drug interactions with Aero-Vent

Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse

effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Storage View Aero-Vent storage conditions for details to ensure optimal

shelf-life.

Description View Aero-Vent description for details of the chemical structure

and excipients (inactive components).

Mechanism of Action

View Aero-Vent mechanism of action for pharmacodynamics and


MIMS Class Antiasthmatic & COPD Preparations

ATC Classification

R03AC02 - Salbutamol ; Belongs to the class of adrenergic

inhalants, selective beta-2-adrenoreceptor agonists. Used in the

treatment of obstructive airway diseases.

Poison Schedule Rx


clobetasol

MIMS Class : Topical Corticosteroids See available brands of clobetasol

See related clobetasol information

Indication Corticosteroid-responsive dermatoses.

Dosage Adult: Topical As 0.05% cream/oint: Apply twice daily.

Click to view Dosage by Indications

Contraindications Childn <12 yrs. Long-term treatment of ulcerative conditions,

rosacea, pruritus; presence of acute infections. Hypersensitivity.

Special Precautions

Heart failure, recent myocardial infarction, hypertension; diabetes

mellitus; epilepsy; glaucoma; hypothyroidism; hepatic failure, renal

impairment; psychoses; childn and elderly. Should not enter eyes.

If infection exists, treat with specific anti-infectives. Pregnancy,

lactation.


Perioral dermatitis, striae esp in flexures. Dermal and epidermal

atrophy esp on the face, steroid purpura.

Potentially Fatal: Prolonged usage of large amount of clobetasol

propionate can lead to sufficient systemic levels to produce

adrenal suppression, Cushing's syndrome, diabetes and

hypertension.

Drug Interactions

Click to view more Drug Interactions

Pregnancy Category (US FDA) Category C: Either studies in animals have revealed adverse

effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Storage For special storage condition to ensure optimal shelf-life of

medicine... click to view

Mechanism of Action

For details of the mechanism of action, pharmacology and

pharmacokinetics and toxicology ... click to view

MIMS Class Topical Corticosteroids

ATC Classification

D07AD01 - clobetasol; Belongs to the class of very potent (group

IV) corticosteroids. Used in the treatment of dermatological

diseases.

Related clobetasol information:

Platexan® [tab]

Apotex [ Patriot ]

MIMS Class : Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)

See related Platexan tab information

Contents Clopidogrel bisulfate

http://www.mims.com/Page.aspx?menuid=mng&name=Platexan+tab&brief=false&CTRY=PH

Indications For the prevention of atherosclerotic events in peripheral arterial

disease, or w/in 35 days of MI, or w/in 6 mth of ischemic stroke, or in

acute coronary syndrome w/o ST-segment elevation.

Dosage Prophylaxis of thromboembolic events 75 mg once daily.

Management of acute coronary sydromes including unstable

angina & non-Q wave MI Single 300 mg loading dose followed by

75 mg daily.



Dyscrasias, serum sickness, interstitial pneumonitis, erythema

multiforme, Stevens-Johnson syndrome, lichen planus, myalgia.

Should be stopped 5-7 days prior to surgery.


Drug Interactions

Anticoagulants, antiplatelets, NSAIDs, bupropion, ciclosporin w/

statin.

View more drug interactions with Platexan



Storage View Platexan storage conditions for details to ensure optimal shelf-

life.

Mechanism of Action

View Platexan mechanism of action for pharmacodynamics and


MIMS Class Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)

ATC Classification

B01AC04 - Clopidogrel ; Belongs to the class of platelet aggregation

inhibitors excluding heparin. Used in the treatment of thrombosis.

Poison Rx

Schedule


ursodeoxycholic acid

MIMS Class : Cholagogues, Cholelitholytics & Hepatic Protectors See available brands of ursodeoxycholic acid

See related ursodeoxycholic acid information

Indication Listed in Dosage.

Dosage Adult: PO Dissolution of cholesterol-rich gallstones 6-12

mg/kg/day as a single dose at bedtime after radiological

disappearance of stones. Max: 15 mg/kg. Primary biliary

cirrhosis 10-15 mg/kg/day in 2-4 divided doses. Prevention of

gallstones in patients undergoing rapid wt loss 300 mg twice

daily.

Click to view Dosage by Indications

Administration Should be taken with food.

Contraindications Calcified and pigment gallstones, radio opaque gallstones.

Nonfunctioning gall bladders; chronic liver and peptic ulcer

disease. Inflammatory disease of colon and small intestine.

Pregnancy.

Special Precautions

50% of successfully treated patients will develop further gallstones

within 10 yr. Lactation.


Diarrhoea, pruritus, nausea, vomiting, gallstone calcification.

Drug Interactions Cholestyramine, charcoal and antacids may reduce effectiveness.

Aluminum-based antacids may reduce absorption. Oestrogens

and clofibrate may counteract effectiveness of ursodeoxycholic

acid by increasing cholesterol elimination in bile. Possible increase

in ciclosporin serum concentration. Decreased effectiveness of

dapsone. Possible decrease in serum ciprofloxacin and

nitrendipine.

Click to view more Drug Interactions



Mechanism of Action

For details of the mechanism of action, pharmacology and

pharmacokinetics and toxicology ... click to view

MIMS Class Cholagogues, Cholelitholytics & Hepatic Protectors

ATC Classification

A05AA02 - ursodeoxycholic acid; Belongs to the class of bile

acids. Used in bile therapy.

Related ursodeoxycholic acid information:

patient jl 2103 (drug study)

Documents