pato fisiologi kuliah 4 temperature

8/16/2019 Pato Fisiologi Kuliah 4 Temperature

1/16

DR. Dr. Tenri Esa, Msi, SpPK

Departemen Patologi Klinik

UNHAS

Temperature, Energy


2/16

The aim o thermoregulation is to maintainthe actual !ore temperature o the "o#y atthe set level o a"out $% & '

the set le(el is raise# in e(er, an# thethermoregulatory me!hanisms are thusresponsi"le or maintaining the raise#

temperature

Fever


3/16


4/16

)e(er is parti!ularly !ommon *ith ine!tions in the !ourse o the acute-phase reaction

Exogenous pyrogens are !onstituents o pathogens, among *hi!h the lipopoly+

sa!!hari#e !omplees -en#otoins o gram+negati(e "a!teria or pyrogens, are

opsoni/e# "y !omplementan#phago!yto/e# 0 ma!rophages 0 sel ku1er

fever


5/16


6/16

'ytokines -23 4, 5, 6, an# 44, intereron 7an# 8 , TN) 7, an# ma!rophage+in9ammatory protein M2P 4 release#

En#egenous pyrogen


7/16

Norepinephrine that has "een release#there !auses the ormation o P:E; an#thus e(er.

release o a#iuretin -ADH< =4 re!eptore1e!t,

>+melano!yte+stimulating hormone ->+MSH, an# the !orti!otropin+releasing hormone

!orti!oli"erin -'RH, endogenousantipyretics


8/16


9/16

The value of fever pro"a"ly lies in its!ountera!ting ine!tion.

The raise# temperature inhi"its therepli!ation o some pathogens, !ells#amage# "y (iruses are #estroye#

Antipyreti!s shoul# in general only "e use#i the e(er lea#s to febrile convulsions,or rises so high -? $@'


10/16


11/16

Bn se(ere physi!al e1ort -in!rease# heatpro#u!tion an#0or in a hot en(ironment-#e!rease# net heat loss

Thermoregulatory me!hanisms o theorganism are o(ertaske#

Co#y,s !ore temperature Set le(el

Hyperthermia, HeatInjuries


12/16


13/16

Potentially lethal result o heterogeneousgeneti! #ee!ts o sar!oplasmi! 'a;transport, in *hi!h the 'a;+releasing!hannel -ryano#ine re!eptor is a1e!te#.

Some inhalation anestheti!s -halothane,in9urane, iso9urane an# #epolari/ing

mus!le relaants -suamethonium !hlori#e!ause the su##en an# e!essi(e release o'a; rom the sar!oplasmi! reti!ulum

Malignant Hyperthermia


14/16

The result is a!i#osis, hyperkalemia,ta!hy!ar#ia, arrhythmia, an# rapi#ly risinghyperthermia

2 re!ogni/e# in time, malignanthyperthermia

!an "e su!!essully treate# "y #is!ontinuing

the anestheti!s an#0or mus!le relaants, as*ell as !ooling the "o#y.


15/16

Malignant Hyperthermia


16/16

selamat belajar

pato fisiologi kuliah 4 temperature

Documents