pattern recognition receptors (prrs) signaling pathways
TRANSCRIPT
LPS
Flagellin
NF-κB
TIRAPMyD88
TLR4
TLR1 TLR2 TLR6 TLR5
TIRAPMyD88
CD14
Nucleus
Caspase-1 Activation
Caspase-1(Caspase-5)
pro-IL-1β
IL-18 (secreted)
IL-1β (secreted)
pro-IL-18
InflammasomesNLRP1, NLRP3, NLRP6,
NLRC4, RIG-I, AIM2
Asc
DNA Sensors
RNA poly IIIDAI
MRE11LRRFIP1DDX41IFI16AIM2
DHX9/36
Toll-like Receptors
RIG
-I-lik
e R
ecep
tors
CARD9Bcl-10MALT1
NO
D-li
ke R
ecep
tors
Cyt
osol
ic D
NA
Sens
ors
RNA poly III
dsDNA (Viral Infection,
Bacteria)
Inflammatory Response
PAMPs / DAMPs
IRF3IRF7
AP1
Inflammation, Immune Regulation, Autophagy, Survival, Proliferation, Apoptosis, Necrosis/Necroptosis
Transcription
MD2
Bacterial Cell Wall Compounds
Lipopeptides LipoglycansPeptidoglycans
STING
β-Catenin
Type I IFNsPro-inflammatory Cytokines & Chemokines
Cytoplasm
RAGEHeparansulfate
HMGB1
TRAMTRIF
MyD88 TRIF
IRF3 IRF7NF-κBAP1
RIP1
TRADD
MAPKp38
Ras
cGAS
cGAMPPKR
eIF-2αP
Protein Synthesis
MAVSBcl-10CARD9
MitochondriaER
Viral dsRNA
ATP +
GTP
TLR10
MyD88
TLR11TLR12
Profilin
NIK
TIRAPMyD88
TRIF
MAPK
Raf-1
Horseshoe-shaped solenoid N-terminal extracellular leucine-rich repeat (LRR) motifs
Compact and globular C-terminal intracellular Toll/interleukin-1 receptor (TIR) domain
ActivationTranslocation TLRs
Inhibition
TLR11/TLR12: Expressed in mice only
?
RIP2CARD9
Nod2MDP
Nod1iE-D
AP
MAPKp38JNK
S100A8/A9C-type Lectin Receptors
Syk
Dectin-1 Dectin-2 Mincle
Syk
FcRγ
SAP130α-MannoseCord Factor
Fungal HyphaeN-linked Mannan
DC-SIGN
N-linked MannanViruses
MycobacteriaZymosanβ-Glucan
PKCδ
RNA Sensors
RIG-IMDA5LGP2
LSm14A
Viral RNA
Viral Infection
+
Tran
sloc
atio
n
TLR4
TLR3TLR7/8 TLR9
EndosomedsRNAssRNA
CpG DNAODNs
CD14
( )4
Pattern Recognition Receptors (PRRs) Signaling Pathways
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