Translating Advanced Science into Personalized

Health and Wellness

Paula J Nenn MD

Senior Medical Director

O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

Who? What? Why?

• 501c3 Non-profit research foundation

• Formed 2 ½ years ago, San Diego based

• Self-care and personal health accountability key to US

economics

• New science – 800 articles per DAY!

• Public Interest in all things ‘alternative’

• New science – personalized medicine, genomics, systems

biology, early predictive biomarkers

• Personal health tracking devices

• Bring it all together into one program?

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O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

‘New’ science

optimalhealth

sub-optimalhealth

pre-disease

chronicdisease

Insulin resistance

Cardiometabolic

Syndrome

Pre-DiabetesDiabetes

Hyperinsulinemia

Diabetes Complications- Leg Amputations

- Kidney & Heart Disease

- Erectile Dysfunction, …

- Blindness

Sta

nd

ard

Am

eri

ca

n D

iet

clinical diagnosticthreshold of disease

conventional diagnosticspreventive / predictive functional assessments

EARLIEST SUB-CLINICAL IMBALANCE AND RISK FACTOR BIOMARKERS

EA

RLY

DE

TE

CT

ION

CHRONIC DISEASES

NEVER JUST HAPPEN

TO YOU, THEY ARE THE

END RESULT OF A

LONG, PROGRESSIVE

DECLINE.

DYNAMIC CONTINUUM

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O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

Tree of Health and Disease

CARDIOLOGY

ENDOCRINOLOGY

NEUROLOGYGASTROENTEROLOGY

PULMONOLOGY

IMMUNOLOGY

ONCOLOGYPSYCHIATRY

Functional Imbalances

Systemic Inflammation

Oxidative Stress

PRE-DISEASE

SUB-OPTIMAL HEALTH

Clinical Diagnostics

EMOTIONAL & MENTAL

BALANCE AND

STRESS RESILIENCE

MACRO & MICRO

NUTRITION

SLEEP,

CIRCADIAN RHYTHMS

& RESTORATIONPHYSICAL ACTIVITY &

STRUCTURAL BALANCE

MICRO ENVIRONMENTAL

PROTECTION

SPIRITUAL &

SOCIAL BALANCE

‘ENERGY SYSTEM’

BALANCE

Functional Assessment Biomarkers

Genetic Predispositions( gate-keepers )

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O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

Optimal Health and Prevention Program

EMOTIONAL & MENTAL

BALANCE AND

STRESS RESILIENCE

MACRO & MICRO

NUTRITION,

AIR, WATERSLEEP,

CIRCADIAN RHYTHMS

& RESTORATIONPHYSICAL ACTIVITY &

STRUCTURAL BALANCE

MICRO ENVIRONMENTAL

PROTECTION

SPIRITUAL &

SOCIAL BALANCE

‘ENERGY SYSTEM’

BALANCE

Functional Assessment

Biomarkers

roots & trunk

OHPProgram

Optimal HealthGPS

Comprehensive Predictive,

Preventive Functional

Biomarker Assessment

OHP Dx

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Personalized, Integrative Self-

care Recommendations

OHP Rx

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Ongoing Educational,

Optimal Health Coaching and

Progress Monitoring Support

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1

2Translational Algorithm &

Artificial Intelligence

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Genetic Predispositions

( gate-keepers )

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O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

Demonstration Project

• 100 subjects chosen from volunteers

• Age, gender, ethnicity matched

• Each acts as their own control

• Start Spring 2011

• In collaboration with Scripps Center for Integrative

Medicine

• Age ≥ 18

• Exclusion criteria: acute illness, pregnancy

• Current chronic illness not an exclusion criterion but must

be stable

• Consent from primary physician

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O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

Registration,EHR &

Questionnaires

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Week 1

O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

Urine & Blood Tests&

questionnaires

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Week 1: Blood and Urine tests

O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

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SNPs(Genomic Saliva

Panel)& questionnaires

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Week 2 - Genetics

O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

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24-hr ABPM24-hr Holter

Saliva Cortisol + DHEA& questionnaires

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Week 3 – Autonomic Nervous System

O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

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Sleep AssessmentEEG + Oximetry& questionnaires

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Week 4 - sleep

O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

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Physical ActivityFood Diary, FFQ

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Week 5 & 6: Caloric Balance, Sleep Actiography

O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

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Physical Tests(Onsite)

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Week 7: Non-Invasive Physical Tests

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Integrative MD Consult

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START…

Week 8: MD and coach

O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

Week 8: Start Program

• Personalized Interventions

• Nutritional recommendations

• Physical activity

• Breathing

• Sleep

• Environmental toxicity

• Stress

• Energy medicine

• Spirituality / connections / gratitude15

O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

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Interim Data Analysis

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Week 12

Week 26

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Final Data Analysis

2012

Week 52: Program Finish

O p t i m a l H e a l t hAND PREVENTION RESEARCH FOUNDATION

Biomonitoring

• Assessment Phase

• 24 hour HRV

• 24 hour AMBP

• 2/52 Body Media – calorie balance, sleep

actiography

• 3 day Apnea link sleep apnea screening

• Zeo Sleep Monitor 7/7

• Text and IVR food diary

• Intervention

• Body Media

• Zeo

• Emotional sampling

• Biofeedback devices: meditation, HRV etc18

Questions?

Paula.Nenn@OptimalHealth.org

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