pbl neuro
DESCRIPTION
membuka kasus dan myimpulkanTRANSCRIPT
![Page 1: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/1.jpg)
Tetraparesis
Modul IGroup 5
![Page 2: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/2.jpg)
MemBerS
Ade Tri Arlini
Fenny Rahayu
Yan Floresta
Widya Nursantari
Fitriana H
Lucky Miftah S
Dita Putri
Feri Idham L
Yusrani R
Amrullah Adji
Elvi Rahmi
Group 5
1st scenario
![Page 3: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/3.jpg)
Scenario
A woman 22 years old brought by her college friend to hospital Emergency Unit because her sudden quadriparesis initially felt only cramps. Unclear existance story trauma in spine. Only known that he hasn't come previous few days lecture because experienced heavy influenzas. Defecate and urinate was normal. This experience is her first time.
![Page 4: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/4.jpg)
Difficult Word
Tetraparesis
Muscle weakness that hit all four extremity.
(Medical Dictionary Dorland)
![Page 5: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/5.jpg)
Key Word
1. A woman 22 years old.
2. Sudden tetraparesis, followed with cramps.
3. Unclear existance story in trauma
4. Heavy influenza in previous history.
5. No cough story.
6. Normal body temperature.
7. Normal defecate and urinate.
8. First time experienced.
![Page 6: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/6.jpg)
Anatomy
![Page 7: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/7.jpg)
![Page 8: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/8.jpg)
![Page 9: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/9.jpg)
![Page 10: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/10.jpg)
![Page 11: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/11.jpg)
![Page 12: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/12.jpg)
![Page 13: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/13.jpg)
![Page 14: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/14.jpg)
![Page 15: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/15.jpg)
![Page 16: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/16.jpg)
Organization of nerves
BrainBrain CNSCNS Spinal CordsSpinal Cords
AfferentAfferent
Sensoric
Stimulate
Sensoric
Stimulate
Viceral
Stimulate
Viceral
Stimulate
EfferentEfferent
System of nerve somatic
System of nerve somatic
System of otonom nerve
System of otonom nerve
Motoric NerveMotoric Nerve
Simpatic nerve system
Simpatic nerve system
Parasimpatic nerve systemParasimpatic nerve system
Muscle contruction
1. Artless muscle
2. Heart muscle
3. Gland
Efector organ (consisted of muscle network and gland
PNSPNS
Fisiology
![Page 17: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/17.jpg)
Lower motor neuron
Upper motor neuron
![Page 18: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/18.jpg)
HistologyNeuroglia is contributor cell on CNS which Non-neural.Neuroglia consists of :1.Astrocyte 2.Oligodendrocyte3.Mikroglia
![Page 19: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/19.jpg)
Preparation of peripheral nerve
1. Endoneurium2. Myelin veil3. Akson4. Perineurium5. Epineurium6. Schwann cell
![Page 20: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/20.jpg)
Preparation of Radix Ganglion Dorsales
![Page 21: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/21.jpg)
Continue…ganglion cell consists of 3 part :
1.Endoneurium
2.Perineurium
3.Epineurium
Ganglion has a body cell, axon, dendrite, and capsule cell or satellite cell.
![Page 22: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/22.jpg)
Preparation of Medulla Spinalis
Medulla Spinalis consist of 2 part :1.White Substance (Alba)2.Gray Substance (Grisea)
![Page 23: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/23.jpg)
Medulla Spinalis Mid-torakal area
Medulla Spinalis mid-torakal area has cornu posterior grisea and cornu anterior grisea. Toracal area contain motorik nerve. Cornu lateral grisea grow greatly in toracal area.
![Page 24: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/24.jpg)
Characteristics UMN LMN
Kind and weakness distribution
Lesion at brain :“piramidalis distribution”, part of distal especially hand muscles; exstensor arm and flexsor feebler leg.
Lesion at medulla spinalis: vary to depend on the location of lesion.
Depend that is radix segment, or which nerve that have a lesion.
TonusSpastisity: real in fleksor arm and ekstensor leg.
Flaccid
Mass MuscleOnly a little experience disuse atrophy muscle.
Atrophy can be very clear
Reflex Increase; Babinski (+) Decrease or no; Babinski (-)
Fasiculation No Yes
Klonus Oftentimes No
Difference
![Page 25: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/25.jpg)
Differential DiagnoseGuillain Barre
SyndromeMyasthenia Gravis Paralisis Periodic
Definition Disease marked by paralysis ascendant that espoused subacute weakness and decrease tendon reflex.
Condition marked by weakness or muscle stupefaction.
Failure transmission neuromuscular and can become normal after few minutes.
Hereditary muscle weakness disease, Autosomal dominant fenotipe
Etiology Vaccination infection, surgery, systematic disease.
Damage AcH receptor neuromuscular junction disease consequence
Autoimmune
High carbohydrate food or Na, rest after activity.
![Page 26: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/26.jpg)
Pathology Virus that step into body is caught by T cell and makrofag assault myelin, besides T cell induction cell b to produce antibody that assault myelin so that disturb impulse conduction in nerve perifer.
Increasing of muscle weakness that caused by total decrease ACH receptor in neuromuscular junction
Muscle weakness happens because enter it ion potassium into muscle cell, finally membrane be hyperpolarisation so that happen pulse transmission obstacle neuromuscular.
Symptoms
Paralisis total fourth movement member, takikardia, aritmia heart, disturbance vasomotor.
Diplopia, face muscle weakness, disfagia, neck muscle weakness and extremitas.
Muscle pain, very thirsty before happen weakness, weak taste is begun at extremitas under and followed with member on body and neck, fisiology reflex decreased or lost, but normal permanent skin sensation.
![Page 27: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/27.jpg)
Epidemiology Average incident per year 0,4-1,7 per 100.000 population. woman: man (2: 1) and many happen in young .
Prevalention 14 per 100.000 population with 36 thousands case happens at axis. In children, adult and parents. in 40 year age, woman more many while on 40 year man more many.
Incident number around 1 between 100.000 person, more many found in man usually aged 10-25 year. age the happening of first attack varies from 1-20 year, attack frequency more at age 15-35 year and then decreased with age enhanced
Therapy Corticosteroid, complication prevention, Plasmaferesis, vital capacity monitoring, NGT
Anticolinesterase (piridostigmin), Corticosteroid, Imunosupresi, Timektomi, Plasmafaresis.
Acetazolamide, Triamterene or Spironolactone if Acetazolamide there is no response.
![Page 28: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/28.jpg)
OTHER NEUROLOGY NUISANCE
1. Miasthenia Gravis– Diplopia (double vision)
2. Guillain-Barre Syndrome– Sensation change that cause contracture– Diplopia
3. Paralysis Periodic– No nuisance found
![Page 29: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/29.jpg)
AnamnesisExaminations: - Physical
- Neurological
• Mental status
• Level of consciousness
• Cranial nerve function
• Motoric function
• Reflex
• Coordination
• Sensoric function
![Page 30: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/30.jpg)
Guillain Barre Syndrome• Paralyzed: LMN type• symmetrical• hyporeflex• Sensorical deficit • N.IV or N.III: diplopia• N.IX and N.X: disphagia, disphonia• Autonomic disorder• Respiratory failure• Papiledema
![Page 31: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/31.jpg)
Laboratory examination: Increasing of protein in LCS: > 0,5 mg % MMN< 10 cell/mm3
Electrophysioogy examination (EMG)
Transmission of motoric nerve and sensoric
nerve velocity become slow
![Page 32: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/32.jpg)
Therapy
Medicamentosa:
• Plasma exchange
• Immunoglobulin IV: 0,4 mg/kgBB
• Corticosteroid
Nonmedicamentosa:• Respiratory cure• Physiotherapy
![Page 33: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/33.jpg)
PRVENTION OF GBS1. Varicella Vaccination (preventing varicella
complication in Central Nerve System /CNS)
2. Mononucleosis
3. AIDS, Herpes simplex, Chalamydia trachomatis infection (STD)
4. Campylobacter jejuni infection
5. Hepatitis B
6. Mycoplasma pneumoniae (infecting CNS)
![Page 34: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/34.jpg)
Miastenia GravisDiagnostic test:• Acetylcholine anti-receptor antibody• Antibody anti-sceletal muscle(anti-striated
muscle antibody) • Tensilon test• Wartenberg test• Prostigmine test
Radiology:AP & lateral position: looking for thymoma
![Page 35: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/35.jpg)
TherapyMedicamentosa:1.Antikolinesterase:
– Piridostigmin 30-120 mg po every 3 hours– Neostigmin bromide 15-45 mg po every 3
hours2.) Steroid : 5-10 mg/week3.) Azatioprin: 2,5 mg/kgBB (8 weeks early)4.) Timectomy 5.) Plasmaferesis: 3-8 times 50mL/kgBB
![Page 36: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/36.jpg)
Nonmedicamentosa:
• Take a rest
• careful to sedative drugs: can cause respiratory depression
![Page 37: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/37.jpg)
PREVENTION OF MG
• Avoid unnecessary drugs such as:
1. D-Penicillamine
2. Interferon Alpha
• Avoid allogenic & Xenogenic Bone Marrow Transplantation
![Page 38: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/38.jpg)
1. D-Penicillamine
• The mechanism was unclear• Some theory says D-Penicillamine
modifies the equilibrium of AcH binding properties of both purified receptor and receptor rich membrane fragments.
• Test in normal rat with normal dose no abnormalities
• Test in guinea pig with high dose Mild Degree Neuromuscular Block
![Page 39: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/39.jpg)
2. Interferon Alpha
• Stimulating over-expression of Interferon gamma at motor end plate, this test was taken in mice
• Results: generalized weakness, abnormal NMJ function, and improvement of cholinesterase inhibitor.
![Page 40: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/40.jpg)
3. Allogenic & Xenogenic Bone Marrow Transplatation
• Results from manifestation of Graft Versus Host Disease (GVHD)
![Page 41: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/41.jpg)
Periodic Paralysis→ muscle atrophy, muscle contracture
Examination: looking for indications such as trauma, poisoned, infection, and headache
Neurological examination: strength test, reflex, and sensation
Laboratory examination:
CT Scan, MRI, EMG & nerve transmission velocity
test (muscle function & peripheral nerve)
![Page 42: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/42.jpg)
TherapyMedicamentosa:• K+ given po/parenteral • Aldakton 100 mg po/day• Thiamine HCl 50 mg/day• Hipertiroidism therapyNonmedicamentosa: High Calium diet, low carbohydrate, low Na,
physical therapy, occupational therapy, Acupuncture ,speaking therapy , Constain Induce Treatment Therapy, Functional Electrical
Stimulation, electrotherapy
![Page 43: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/43.jpg)
PREVENTION OF PARALYSIS PERIODIC
• No prevention because of an hereditary disease.
![Page 44: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/44.jpg)
ReferencesSobbota
Neuro Anatomy
Anatomi Dasar Klinis
Patofisiologi Konsep Dasar Penyakit
Neurologi Klinis Dasar
Histologi fiore
www.medicineonline.com
www.medlineplus.com
![Page 45: PBL Neuro](https://reader037.vdocument.in/reader037/viewer/2022102721/545f8671b1af9fe6108b4aad/html5/thumbnails/45.jpg)
Thanks for a
ttentio
n
Group 5