Upload File

pd-l1 market insights

1

Upload: diaceutics-group

Post on 11-Apr-2017

175 views

Category:

Healthcare


0 download

Report

TRANSCRIPT

Page 1: PD-L1 Market Insights

PD-L1/PD-1 crosstalk in colorectal cancer: are we

Combination regimens with PD-1/PD-L1 immune checkpoint ......REVIEW Open Access Combination regimens with PD-1/PD-L1 immune checkpoint inhibitors for gastrointestinal malignancies

A new standardized CD8 and PD-L1 dual assay...Halioseek PD-L1/CD8 staining D. Halioseek PD-L1/CD8 virtual slides of four NSCLC samples x20Correlation between Halioseek PD-L1/CD8 and

A correlative analysis of PD-L1, PD-1, PD-L2, EGFR, …...2018/02/13  · 1 A correlative analysis of PD-L1, PD-1, PD-L2, EGFR, HER2, and HER3 expression in oropharyngeal squamous

The effect of PD-L1 status on survival outcomes in ... · PD-L1 and PD-1 in tumor cells and PD-L1 in tumor infiltrat-ing inflammatory cells. Results: In a total 74 patients, 45.9%

Ex Vivo PD-L1/PD-1 Pathway Blockade Reverses Dysfunction of …clincancerres.aacrjournals.org/content/clincanres/early/... · Ex Vivo PD-L1/PD-1 Pathway Blockade Reverses Dysfunction

PARP Inhibitor Upregulates PD-L1 Expression and ...clincancerres.aacrjournals.org/content/clincanres/23/14/3711.full.pdf · via upregulation of PD-L1, and blockade of PD-L1 resensi-tized

StructureandInteractionsoftheHumanProgrammedCell ... · and CTLA-4, PD-L1 and PD-L2 are B7 family proteins com-prisedoftandemV-setandC1-setIgSFdomains.Inadditionto PD-1, PD-L1 binds

Monitoring the response to immunotherapy through the use ......Atezolizumab PD-L1 Bladder Ca, NSCLC Avelumab PD-L1 Merkel cell Durvalumab PD-L1 Urothelial carcinoma ... • bladder

The mechanism of anti-PD-L1 antibody efficacy against PD ......The mechanism of anti-PD-L1 antibody efficacy against PD-L1 negative tumors identifies NK cells expressing PD-L1 as a

PD‐L1 immunohistochemistryas a predictivebiomarker: pros ... · OthermethodsforPD‐L1 detection PD‐L1 mRNA PD‐L1low < median expression (n=355) PD‐L1high ≥ median expression

VENTANA PD-L1 (SP142) Assay Guiding immunotherapyreagent-catalog.roche.com/documents/PD-L1_SP142-Brochure.pdf · Elevated PD-L1 expression on tumor cells has been associated with

The Mechanism of Anti PD-L1 Antibody Efficacy against PD ... · Our discovery of a PD-1–independent mechanism of antitumor efficacy via the activa-tion of PD-L1+ NK cells with anti–PD-L1

Research Paper Harnessing stemness and PD-L1 expression …Research Paper Harnessing stemness and PD-L1 expression by AT-rich ... Clinical sample analyses ... ISC genes, and PD-L1

are independent biomarkers in most cancers PD-L1 ... · Relationship of PD-L1 expression and cancer genomics. Figure 3 shows TMB for all PD-L1–negative, PD-L1– low-positive, and

PD-1/PD-L1 inhibitors in hematological malignancies, with ...oncologypro.esmo.org/.../2374963/file/2017...Hodgkin-Soon-Thye-Lim.pdf · PD-1/PD-L1 inhibitors in hematological malignancies,

PD-L1 Testing German Experiencemedia.aiom.it/userfiles/files/doc/AIOM-Servizi/... · PD-L1 NSCLC; final report EGFR IHC sqNSCLC. final report PD-L1 Melanoma (2) final report T790M

PD-L1 IHC 22C3 pharmDx Interpretation Manual, …...PD-L1 IHC 22C3 pharmDx Interpretation Manual – Head and Neck Squamous Cell Carcinoma (HNSCC) 8 Programmed death-ligand 1 (PD-L1)

VENTANA PD-L1 (SP263) Assay Guiding immunotherapy for ... · About PD-L1 PD-L1 is a transmembrane protein that downregulates immune responses through binding to its two receptors

PD-L1 Market Insights Report

Authors: Jen Carlstrom Jeanine Hinterneder Dawn Nida · PD-L1 detection kit can measure soluble PD-L1 from cell supernatant samples and membrane-associated PD-L1 from within cellular

PD-L1 IHC 22C3 pharmDx SK006... · Merck Sharp & Dohme sponsored clinical study, KEYNOTE-158 (KN158), investigated the clinical validity of PD-L1 IHC 22C3 pharmDx in identifying PD-L1

PD-L1 Expression and Combined Status of PD-L1/PD-1

PD-1 and PD-L1 CCBT: An Opportunity Hemophilia: Treatment

Safety of Anti-Pd1/Pd-L1 Antibodies in Melanoma€¦ · Safety of Anti-PD1/PD-L1 Antibodies in Melanoma. ABSTRACT. Immune checkpoint inhibitors and in particular anti-PD-1/PD-L1 antibodies

Review Soluble PD-1 and PD-L1: predictive and prognostic

Meta-Analysis PD-1/PD-L1 antibodies efficacy and safety

Quarterly Health Topics Series Sanofi’s Vision in Oncology · 2016 2020 2025 Source: IMS Health European Thought Leadership PD-1/PD-L1 PD-1/PD-L1 PD-1/PD-L1 CTLA-4 CTLA-4 CTLA-4

Quantitative PET imaging of PD-L1 expression in xenograft ... · Methods Anti-PD-L1 (clone 6E11, ... grafts and syngeneic mouse tumour models with varying PD-L1 expression. Lastly,

PD-L1 regulates the development, maintenance, and function of … · 3016 PD-L1 promotes iT reg development and function | Francisco et al. Figure 1. PD-L1 mediates Foxp3+ iT reg

Preliminary Biomarker Analysis of Sitravatinib in Combination ......2018/11/07  · PRIOR TESTING CENTRAL LAB BEST PD-L1 RESULT RESPONSE High PD-L1 High CR High PD-L1 No/Low PD-L1

GUIDE TO SCORING PD-L1 EXPRESSION USING ...6 7 IDENTIFY PATIENTS WITH PD-L1 EXPRESSION USING CPS PD-L1 expression status helps inform treatment decisions with KEYTRUDA SELECTED SAFETY

PD-L1 IHC 22C3 pharmDx Interpretation Manual – Esophageal ... · PD-L1 IHC 22C3 pharmDx Interpretation Manual – Esophageal Squamous Cell Carcinoma (ESCC) 6 PD-L1 IHC 22C3 pharmDx

PD-L1 microSPECT/CT Imaging for Longitudinal Monitoring of ... · Research Article PD-L1 microSPECT/CT Imaging for Longitudinal Monitoring of PD-L1 Expression in Syngeneic and Humanized

Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells ...impactournalscom/oncotarget/ ncotarget upplementar aterials 21 Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells