peer review report phase 1 turks and caicos islands

8/4/2019 Peer Review Report Phase 1 Turks and Caicos Islands

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BJI@KJ GIP^M IO TPKOVQKPNOFX KOD N\FLKOBNIG HOGIPMKTHIO GIP TK\ Q^PQIVNV

Qnnp Pnwhnr Pnqipt Qlkvn ;Jnbkj kod Pnb~jktipx Gpkmnripc

T^PCV KOD FKHFIV HVJKODV


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Bji`kj Gip~mio Tpkovqkpnofx

kod N|flkobnig Hogipmkthio gip Tk|

Q~pqivnv Qnnp Pnwhnrv5T~pcv kod Fkhfiv Hvjkodv

01;;QLKVN ;

K~b~vt 01;;,pngjnfthob tln jnbkj kod pnb~jktipx gpkmnripckv kt Mkx 01;;(


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QNNP PNWHNR PNQIPT QLKVN ;5 JNBKJ KOD PNB^JKTIPX GPKMNRIPC T^PCV KOD FKHFIV HVJKODV INFD 01;;

TK@JN IG FIOTNOTV 6

Tk`jn ig Fiotnotv

K`i~t tln Bji`kj Gip~m / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / >

N|nf~thwn v~mmkpx / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / 2

Hotpid~fthio / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / 8

Hogipmkthio kod mntlidijibx ~vnd gip tln qnnp pnwhnr ig tln T~pcv kodFkhfiv Hvjkodv/ / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / 8Iwnpwhnr ig tln T~pcv kod Fkhfiv Hvjkodv/ / / / / / / / / / / / / / / / / / / / / / / / / / / / / / ;1Pnfnot dnwnjiqmnotv / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / ;6

Fimqjhkofn rhtl tln Vtkodkpdv / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / ;>K/ Kwkhjk`hjhtx ig hogipmkthio / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / ;>

Iwnpwhnr / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / ;>K/;/ Ironpvlhq kod hdnothtx hogipmkthio / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / /;7K/0/ Kffi~othob pnfipdv / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / 60K/6/ @kochob hogipmkthio / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / 6>

@/ Kffnvv ti Hogipmkthio / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / 62

Iwnpwhnr / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / 62@/;/ Fimqntnot k~tliphtxv k`hjhtx ti i`tkho kod qpiwhdn hogipmkthio / / / / / / / / 6

Iwnpwhnr / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / 4>F/;/ N|flkobn ig hogipmkthio mnflkohvmv / / / / / / / / / / / / / / / / / / / / / / / / / / / / / 47F/0/ N|flkobn ig hogipmkthio mnflkohvmv rhtl kjj pnjnwkot qkptonpv / / / / / / / / >;F/6/ Fioghdnothkjhtx / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / / >0F/4/ Phbltv kod vkgnb~kpdv ig tk|qkxnpv kod tlhpd qkpthnv/ / / / / / / / / / / / / / / / / / >6

F/>/ Thmnjhonvv ig pnvqiovnv ti pn{~nvtv gip hogipmkthio / / / / / / / / / / / / / / / / / / >>


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4 TK@JN IG FIOTNOTV

V~mmkpx ig Dntnpmhokthiov kod Gkftipv ^odnpjxhob Pnfimmnodkthiov / / / / >2

Koon| ;5 E~phvdhfthiov Pnvqiovn ti tln Pnwhnr Pnqipt / / / / / / / / / / / / / / / / / / 7;

Koon| 05 Jhvt ig kjj N|flkobn-ig-Hogipmkthio Mnflkohvmv ho Gipfn / / / / / / / / 76Koon| 65 Jhvt ig kjj Jkrv* Pnb~jkthiov kod Itlnp Pnjnwkot Mktnphkj / / / / / / / 74


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K`i~t tln Bji`kj Gip~m

Tln Bji`kj Gip~m io Tpkovqkpnofx kod N|flkobn ig Hogipmkthio gip Tk|Q~pqivnv hv tln m~jthjktnpkj gpkmnripc rhtlho rlhfl ripc ho tln kpnk ig tk|tpkovqkpnofx kod n|flkobn ig hogipmkthio hv fkpphnd i~t `x iwnp ;11 e~phvdhf-

thiov rlhfl qkpthfhqktn ho tln Bji`kj Gip~m io ko n{~kj giithob/Tln Bji`kj Gip~m hv flkpbnd rhtl ho-dnqtl miohtiphob kod qnnp pnwhnr ig

tln hmqjnmnotkthio ig tln hotnpokthiokj vtkodkpdv ig tpkovqkpnofx kod n|flkobnig hogipmkthio gip tk| q~pqivnv/ Tlnvn vtkodkpdv kpn qphmkphjx pngjnftnd ho tln0110 INFD Midnj Kbpnnmnot io N|flkobn ig Hogipmkthio io Tk| Mkttnpvkod htv fimmnotkpx* kod ho Kpthfjn 07 ig tln INFD Midnj Tk| Fiownothio io

Hofimn kod io Fkqhtkj kod htv fimmnotkpx kv ~qdktnd ho 0114* rlhfl lkv `nnohofipqipktnd ho tln ^O Midnj Tk| Fiownothio/

Tln vtkodkpdv qpiwhdn gip hotnpokthiokj n|flkobn io pn{~nvt ig gipnvnnk`jxpnjnwkot hogipmkthio gip tln kdmhohvtpkthio ip nogipfnmnot ig tln dimnvthf tk|jkrv ig k pn{~nvthob qkptx/ Ghvlhob n|qndhthiov kpn oit k~tliphvnd `~t kjj gipn-vnnk`jx pnjnwkot hogipmkthio m~vt `n qpiwhdnd* hofj~dhob `koc hogipmkthiokod hogipmkthio lnjd `x ghd~fhkphnv* pnbkpdjnvv ig tln n|hvtnofn ig k dimnvthftk| hotnpnvt ip tln kqqjhfkthio ig k d~kj fphmhokjhtx vtkodkpd/

Kjj mnm`npv ig tln Bji`kj Gip~m* kv rnjj kv e~phvdhfthiov hdnothghnd `xtln Bji`kj Gip~m kv pnjnwkot ti htv ripc* kpn `nhob pnwhnrnd/ Tlhv qpifnvv hv~odnptkcno ho tri qlkvnv/ Qlkvn ; pnwhnrv kvvnvv tln {~kjhtx ig k e~phvdhf-thiov jnbkj kod pnb~jktipx gpkmnripc gip tln n|flkobn ig hogipmkthio* rlhjnQlkvn 0 pnwhnrv jiic kt tln qpkfthfkj hmqjnmnotkthio ig tlkt gpkmnripc/ VimnBji kj Gip~m mnm`npv kpn ~odnpbihob fim`hond Qlkvn ; qj~v Qlkvn 0 pnwhnrv/ Tln Bji`kj Gip~m lkv kjvi q~t ho qjkfn k qpifnvv gip v~qqjnmnotkpxpnqiptv ti gijjir-~q io pnfimmnodkthiov* kv rnjj kv gip tln iobihob miohtip-hob ig e~phvdhfthiov gijjirhob tln fiofj~vhio ig k pnwhnr/ Tln ~jthmktn bikj hvti lnjq e~phvdhfthiov ti nggnfthwnjx hmqjnmnot tln hotnpokthiokj vtkodkpdv ig tpkovqkpnofx kod n|flkobn ig hogipmkthio gip tk| q~pqivnv/

Kjj pnwhnr pnqiptv kpn q~`jhvlnd iofn kqqpiwnd `x tln Bji`kj Gip~m kodtlnx tl~v pnqpnvnot kbpnnd Bji`kj Gip~m pnqiptv/

Gip mipn hogipmkthio io tln ripc ig tln Bji`kj Gip~m io Tpkovqkpnofxkod N|flkobn ig Hogipmkthio gip Tk| Q~pqivnv* kod gip fiqhnv ig tln q~`jhvlndpnwhnr pnqiptv* qjnkvn pngnp tirrr/infd/ipb)tk|)tpkovqkpnofx /

K@I^T TLN BJI@KJ GIP^M >


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N\NF^THWN V^MMKPX 2

N|nf~thwn v~mmkpx

;/ Tlhv pnqipt v~mmkphvnv tln jnbkj kod pnb~jktipx gpkmnripc gip tpkovqkpnofx kod n|flkobn ig hogipmkthio ho tln T~pcv kod Fkhfiv Hvjkodv/

0/ Tln hotnpokthiokj vtkodkpd rlhfl hv vnt i~t ho tln Bji`kj Gip~mvTnpmv ig Pngnpnofn ti Miohtip kod Pnwhnr Qpibpnvv Tirkpdv Tpkovqkpnofxkod N|flkobn ig Hogipmkthio* hv fiofnpond rhtl tln kwkhjk`hjhtx ig pnjnwkothogipmkthio rhtlho k e~phvdhfthio* tln fimqntnot k~tliphtxv k`hjhtx ti bkhothmnjx kffnvv ti tlkt hogipmkthio* kod rlntlnp tlkt hogipmkthio fko `n nggnf-thwnjx n|flkobnd rhtl htv n|flkobn ig hogipmkthio ,NIH( qkptonpv/

6/ Tln T~pcv kod Fkhfiv Hvjkodv hv k vmkjj @phthvl Iwnpvnkv Tnpphtipxjifktnd ho tln Oiptl Ktjkothf Ifnko/ Ti~phvm* ghvlhob kod iggvlipn ghokofhkjvnpwhfnv kpn tln qphmkpx dphwnpv ig htv nfioimx/ Htv mkho tpkdhob qkptonpv kpntln ^ohtnd Vtktnv* ^ohtnd Chobdim kod Fkokdk* kod htv igghfhkj f~ppnofx hv

tln ^V dijjkp ,^VD(/4/ Ho 0118* qkptv ig tln T~pcv kod Fkhfiv Hvjkodv Fiovtht~thio rnpn v~v-

qnodnd x tln @phthvl biwnpomnot/ Tln qirnp ig tln T~pcv kod Fkhfiv Biwnpo-mnot hv f~ppnotjx wnvtnd ho tln Biwnpoip kjion/

>/ Tln T~pcv kod Fkhfiv Hvjkodv lkv ripcnd rhtl tln INFD ho pnvqnftig tk| hogipmkthio n|flkobn vhofn 0110 kod vhofn 0117 lkv qkpthfhqktnd ho kjjig tln Bji`kj Gip~mv koo~kj kvvnvvmnotv/ Ho 0118 ht `nfkmn k mnm`np ig tlnBji`kj Gip~m kod fimmhttnd ti tln hotnpokthiokj vtkodkpd gip tpkovqkpnofxkod n|flkobn ig hogipmkthio gip tk| q~pqivnv/ Kv kt 7 Mkx 01;; ht lkv vhbondNIH kbpnnmnotv rhtl ;7 e~phvdhfthiov* ig rlhfl vnwno lkwn `nno `pi~blt hotigipfn/ Tln T~pcv kod Fkhfiv Hvjkodv lkv tkcno kjj vtnqv gip htv qkpt rlhfl kpnonfnvvkpx ti `phob koitlnp vnwno hoti gipfn* kod lkv oithghnd htv NIH qkptonpvkffipdhobjx/

7/ Tln mkho fiofnpov hdnothghnd ho tln pnqipt pnjktn ti tln kwkhjk`hjhtx ig kffi~othob hogipmkthio kod tln fimqntnot k~tliphtxv kffnvv ti hogipmkthio/Jnbkj pn{~hpnmnotv gip pnjnwkot noththnv kod kppkobnmnotv kod tlnhp vnpwhfn

qpiwhdnpv ti mkhotkho kffi~othob pnfipdv kpn oit v~gghfhnotjx fimqpnlnovhwn*nvqnfhkjjx ho pnvqnft ig ~odnpjxhob dif~mnotkthio v~fl kv howihfnv kod fio-

tpkftv kod tln mhohm~m ghwn xnkp pntnothio qnphid/


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< N\NF^THWN V^MMKPX

2/ Ho tnpmv ig kffnvv ti hogipmkthio* tln Tk| Hogipmkthio N|flkobnIpdhokofn dinv oit k~tliphvn tln T~pcv kod Fkhfiv Hvjkodv fimqntnot k~tlip-htx gip hotnpokthiokj n|flkobn ig hogipmkthio ho tk| mkttnpv tln QnpmkonotVnfpntkpx* Ghokofn ti i`tkho hogipmkthio gip NIH q~pqivnv ~ojnvv v~flhogipmkthio hv5 ,k( lnjd `x k `koc ip itlnp ghokofhkj hovtht~thio* ip kox qnpviokfthob ho ko kbnofx ip ghd~fhkpx fkqkfhtx* hofj~dhob k oimhonn ip tp~vtnn3 ip ,`( tln hogipmkthio pnjktnv ti tln `nonghfhkj ironpvlhq ig k fimqkox* qkptonp-vlhq ip itlnp qnpvio/ Tlhv hv k vnphi~v vliptfimhob tlkt pnvtphftv tln vfiqn ig hogipmkthio tlkt mkx `n i`tkhond kod n|flkobnd `x tln T~pcv kod FkhfivHvjkodv/ Ht kjvi kggnftv tln T~pcv kod Fkhfiv Hvjkodv k`hjhtx ti fimqjx g~jjxrhtl tln tnpmv ig tln NIH kbpnnmnotv tlkt ht lkv notnpnd hoti/ Tln T~pcv kodFkhfiv Hvjkodv lkv pnfnotjx nokftnd jnbhvjkthio ti kddpnvv tlhv hvv~n/ Lirnwnp tlhv fkooit `n tkcno hoti kffi~ot ho tlhv pnqipt kv ht rkv oit ho gipfn kv ig Mkx01;;/


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HOTPID^FTHIO 8

Hotpid~fthio

Hogipmkthio kod mntlidijibx ~vnd gip tln qnnp pnwhnr ig tln T~pcvkod Fkhfiv Hvjkodv

;1/ Tln kvvnvvmnot ig tln jnbkj kod pnb~jktipx gpkmnripc ig tln T~pcv kodFkhfiv Hvjkodv rkv `kvnd io tln hotnpokthiokj vtkodkpdv gip tpkovqkpnofx kodn|flkobn ig hogipmkthio kv dnvfph`nd ho tln Bji`kj Gip~mv Tnpmv ig Pngnpnofnti Miohtip kod Pnwhnr Qpibpnvv Tirkpdv Tpkovqkpnofx kod N|flkobn ig

Hogipmkthio Gip Tk| Q~pqivnv * kod rkv qpnqkpnd ~vhob tln Bji`kj Gip~mv Mntlidijibx gip Qnnp Pnwhnrv kod Oio-Mnm`np Pnwhnrv / Tln kvvnvvmnot rkv `kvnd io tln jkrv* pnb~jkthiov* kod n|flkobn ig hogipmkthio mnflkohvmv hogipfn ip nggnft kv kt Mkx 01;;* itlnp mktnphkjv v~qqjhnd `x tln T~pcv kod FkhfivHvjkodv* kod hogipmkthio v~qqjhnd `x qkptonp e~phvdhfthiov/

;;/ Tln Tnpmv ig Pngnpnofn pnkc diro tln vtkodkpdv ig tpkovqkpnofx kodn|flkobn ig hogipmkthio hoti ;1 nvvnothkj njnmnotv kod 6; no~mnpktnd kvqnftv~odnp tlpnn `pikd fktnbiphnv5 ,K( kwkhjk`hjhtx ig hogipmkthio3 ,@( kffnvv tihogipmkthio3 kod ,F( n|flkobhob hogipmkthio/ Tlhv pnwhnr kvvnvvnv tln T~pcvkod Fkhfiv Hvjkodv jnbkj kod pnb~jktipx gpkmnripc kbkhovt tlnvn njnmnotvkod nkfl ig tln no~mnpktnd kvqnftv/ Ho pnvqnft ig nkfl nvvnothkj njnmnot kdntnpmhokthio hv mkdn tlkt nhtlnp5 ,h( tln njnmnot hv ho qjkfn3 ,hh( tln njnmnothv ho qjkfn `~t fnptkho kvqnftv ig tln jnbkj hmqjnmnotkthio ig tln njnmnot onndhmqpiwnmnot3 ip ,hhh( tln njnmnot hv oit ho qjkfn/ Tlnvn dntnpmhokthiov kpn

kffimqkohnd `x pnfimmnodkthiov gip hmqpiwnmnot rlnpn pnjnwkot/;0/ Tln kvvnvvmnot rkv fiod~ftnd `x ko kvvnvvmnot tnkm rlhfl fimqphvndtri n|qnpt kvvnvvipv5 Mp Kwwkph Vpnnohwkvk Pki* Dhpnftip* Gipnhbo Tk| kodTk| Pnvnkpfl HH ig tln Hodhko Mhohvtpx ig Ghokofn3 kod Mp Qlhjhqqn Fklkoho*Dnq~tx Dhpnftip ho tln Jkpbn @~vhonvv K~dht @pkofl ig tln Gpnofl Pnwno~nKdmhohvtpkthio3 kod ion pnqpnvnotkthwn ig tln Bji`kj Gip~m Vnfpntkphkt*Mp/ B~iulh Gii/ Tln kvvnvvmnot tnkm kvvnvvnd tln jnbkj kod pnb~jktipx gpkmn-ripc gip tpkovqkpnofx kod n|flkobn ig hogipmkthio kod pnjnwkot n|flkobn ig hogipmkthio mnflkohvmv ho tln T~pcv kod Fkhfiv Hvjkodv/


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;1 HOTPID^FTHIO

Iwnpwhnr ig tln T~pcv kod Fkhfiv Hvjkodv

;6/ Tln T~pcv kod Fkhfiv Hvjkodv hv k @phthvl iwnpvnkv tnpphtipx fimqphv-hob tri hvjkod bpi~qv ho tln Ktjkothf Ifnko3 tln jkpbnp Fkhfiv Hvjkodv kod tlnvmkjjnp T~pcv Hvjkodv rhtl k titkj jkod kpnk ig kì~t 461 v{~kpn chjimntpnv/Nhblt ig htv 41 hvjkodv kpn holk`htnd* rhtl k titkj qiq~jkthio ig kqqpi|hmktnjx60 111/ Tln fkqhtkj hv Fifc`~po Tiro* jifktnd io tln Bpkod T~pc Hvjkod/

;4/ Tln T~pcv kod Fkhfiv Hvjkodv nfioimx hv `kvnd qphmkphjx io ti~phvm*ghvlhob* kod iggvlipn ghokofhkj vnpwhfnv/ Ht pnfnhwnv mipn tlko 011 111 ti~phvtv

qnp xnkp* mivtjx gpim tln ôhtnd Vtktnv/ Tln T~pcv kod Fkhfiv Hvjkodv igghfhkjf~ppnofx hv tln ôhtnd Vtktnv Dijjkp ,^VD(/ Ho 011< htv bpivv dimnvthf qpid~ftrkv kqqpi|hmktnjx ^VD / Tln T~pcv kod Fkhfiv Hvjkodv Fiovtht~thio Ipdnp 0117 nvtk`jhvlndk qkpjhkmnotkpx vxvtnm ig biwnpomnot* rlhfl hofj~dnd k Fk`hont kod Li~vnig Kvvnm jx/ [~nno Njhuk`ntl HH hv tln lnkd ig vtktn* kod tln @phthvl Fpiro hvpnqpnvnotnd `x k Biwnpoip kqqihotnd `x tln [~nno/

;7/ Tln T~pcv kod Fkhfiv Hvjkodv jnbkj vxvtnm hv `kvnd io Nobjhvlfimmio jkr* kod pnjnwkot jnbhvjkthio hv nokftnd nhtlnp gpim tln ôhtnd

Chobdim ,^C( jnbhvjkt~pn* rlhfl m~vt `n vqnfhghfkjjx n|tnodnd ti tln T~pcvkod Fkhfiv Hvjkodv ti lkwn nggnft* ip jifkj jnbhvjkthio/ Tlnpn hv ion okthiokj jkrkod tlnpn kpn oi qijhthfkj v~`dhwhvhiov rhtlho tln T~pcv kod Fkhfiv Hvjkodv/

;2/ Tlnpn kpn tri txqnv ig jnbhvjkthio qphmkpx jnbhvjkthio rlhfl hv f~p-pnotjx nokftnd `x tln Biwnpoip* kod v~ìpdhoktn jnbhvjkthio rlhfl hv mkdn `xlhm ip itlnp biwnpomnot ìdhnv ~odnp tln k~tliphtx ig qphmkpx jnbhvjkthio/V~ìpdhoktn jnbhvjkthio hofj~dnv P~jnv* Pnb~jkthiov kod Ipdnpv/ Tlnpn hv kjifkj tlpnn thnp-fi~pt vxvtnm fimqphvhob tln Mkbhvtpktnv Fi~pt* V~qpnmnFi~pt kod tln Fi~pt ig Kqqnkj* kv rnjj kv k g~ptlnp phblt ig kqqnkj ti tln QphwxFi~ofhj ho Jiodio/

;


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HOTPID^FTHIO ;;

tk|nv/ Hovtnkd* tln T~pcv kod Fkhfiv Hvjkodv hv ghokofnd x k fiov~mqthio-`kvndtk| vxvtnm* gif~vnd qphmkphjx io f~vtimv d~tx* rlhfl hv v~qqjnmnotnd x tk|nvkod biwnpomnot gnnv v~fl kv vtkmq d~thnv* qkvvnobnp gnnv* kffimmidkthio tk|kod ripc qnpmht gnnv/

Tln T~pcv kod Fkhfiv Hvjkodv fimmnpfhkj jkrv kod ghokofhkj vnftip

01/ Tln T~pcv kod Fkhfiv Hvjkodv lkv k vmkjj ghokofhkj vnpwhfnv hod~vtpxiggnphob ìtl pnvhdnot kod oio-pnvhdnot vnpwhfnv kod rlhfl hv dimhoktnd `xtln iggvlipn vnftip/ Ghokofhkj vnpwhfnv pnqpnvnot kì~t ;1. ig tln BDQ ; / Kvig 0112* tlnpn rnpn < `kocv* ;8 qpignvvhiokj tp~vtnnv kod 4; fimqkox mko-kbnpv vnpwhfhob kqqpi|hmktnjx ;> 111 n|nmqt fimqkohnv pnbhvtnpnd ho tlnT~pcv kod Fkhfiv Hvjkodv/0 Pnbhvtpkthio gnnv gpim tln Fimqkohnv* Qktnotv kodTpkdnmkpcv pnbhvtpx mkdn ~q kì~t 2;. ig tln titkj pnwno~n fijjnftnd `x tlnGhokofhkj Vnpwhfnv Fimmhvvhio gip tln ghokofhkj xnkp 01;1/ Tln titkj kvvntvig tln `kochob vnftip vtiid kt ^VD ;/26 `hjjhio kv ig Mkpfl 01;1/ 6

0;/ Tln T~pcv kod Fkhfiv Hvjkodv lkv k vhobjn hodnqnodnot ghokofhkjpnb~jktipx k~tliphtx tln Ghokofhkj Vnpwhfnv Fimmhvvhio ,GVF( rlhfl rkvnvtk`jhvlnd ho 011;/ Ht hv biwnpond `x k @ikpd ig Dhpnftipv kqqihotnd `x tlnBiwnpoip kod hv g~odnd `x jhfnofn gnnv bnonpktnd gpim pnb~jktnd ghokofhkjghpmv/ Htv pnvqiovh`hjhthnv hofj~dn5

tln bnonpkj kdmhohvtpkthio ig tln pnb~jktipx pnbhmn nvtk`jhvlnd `xwkphi~v vtkt~tnv* hofj~dhob jhfnovhob kod v~qnpwhvhob fimqjhkofn rhtltln jkrv tlkt kqqjx ti `kochob `~vhonvv* hov~pkofn `~vhonvv* m~t~kjg~odv kod kdmhohvtpkthio kod hownvtmnot `~vhonvvnv ,vnf~phthnv(*tp~vtnnv kod fipqipktn vnpwhfn qpiwhdnpv3

v~qnpwhvhio ig fimqjhkofn rhtl tln Qpifnndv ig Fphmn Ipdhokofnpn{~hpnmnotv kv tlnx pnjktn ti Oio Pnb~jktnd Ghokofhkj @~vhonvvnv,OPG@v(* rlhfl fimqphvn Pnkj Nvtktn Kbnotv* Enrnjjnpv* Jkrxnpv*Kffi~otkotv kod itlnp qpignvvhiokjv kod Oitkphnv kod E~vthfnv ig tlnQnkfn3 kod

pnbhvtpkthio ig fimqkohnv* tpkdnmkpcv kod qktnotv/

00/ Ho tln qnpgipmkofn ig htv g~ofthiov* tln GVF fiod~ftv ìtl iovhtn kvrnjj kv iggvhtn pnb~jktipx v~qnpwhvhio/

;/ Ghb~pn {~itnd gpim T~pcv kod Fkhfiv Dnqkptmnot ig Nfioimhf Qjkoohob kodVtkthvthfv/

0/ Ghb~pnv gpim T~pcv kod Fkhfiv 011< FGKTG M~t~kj Nwkj~kthio Pnqipt/6/ Ghb~pnv gpim tln T~pcv kod Fkhfiv Ghokofhkj Vnpwhfnv Pnqipt 01;1/


14/70


15/70


HOTPID^FTHIO ;6

Pnfnot dnwnjiqmnotv

02/ Tln T~pcv kod Fkhfiv Hvjkodv qkvvnd tln THN Ipdhokofn io 00 Dnfnm- `np 0118/ Ho Gn`p~kpx 01;;* tln T~pcv kod Fkhfiv Hvjkodv dnfhdnd ti qpibpnvvgpim tln tpkovhthiokj rhtllijdhob tk| kppkobnmnot ti ko k~timkthf n|flkobn ig hogipmkthio pnbhmn ~odnp tln N~piqnko Vkwhobv Dhpnfthwn/

0 E~jx 01;;/Tln q~pqivn ig tlhv kmnodmnot rkv ti kddpnvv tln hvv~n hdnothghnd ~odnp njnmnot @/;/ Kmnodmnotv ti tln Fimqkohnv Ipdhokofn kod tln JhmhtndQkptonpvlhqv Ipdhokofn ti mnnt tln pnfimmnodkthiov ig tln kvvnvvipv ~odnp njnmnot K/0 rhjj fimn hoti gipfn io 08 E~jx 01;;/ Kv tlnvn kmnodmnotv rnpnoit ho gipfn kv kt Mkx 01;;* tlnx lkwn oit `nno kvvnvvnd ho tlhv pnqipt/


16/70


17/70


FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO ;>

Fimqjhkofn rhtl tln Vtkodkpdv

K/ Kwkhjk`hjhtx ig hogipmkthio

Iwnpwhnr

08/ Nggnfthwn n|flkobn ig hogipmkthio pn{~hpnv tln kwkhjk`hjhtx ig pnjhk`jnhogipmkthio/ Ho qkpthf~jkp* ht pn{~hpnv hogipmkthio io tln hdnothtx ig ironpvkod itlnp vtkcnlijdnpv kv rnjj kv kffi~othob hogipmkthio io tln tpkovkfthiovfkpphnd i~t `x noththnv kod itlnp ipbkohukthiokj vtp~ft~pnv/ V~fl hogipmkthiomkx `n cnqt gip tk|* pnb~jktipx* fimmnpfhkj ip itlnp pnkviov/ Hg hogipmkthiohv oit cnqt ip tln hogipmkthio hv oit mkhotkhond gip k pnkviok`jn qnphid ig thmn* k e~phvdhfthiov fimqntnot k~tliphtx mkx oit `n k`jn ti i`tkho kod qpi-whdn ht rlno pn{~nvtnd/ Tlhv vnfthio ig tln pnqipt kvvnvvnv tln kdn{~kfx ig tln T~pcv kod Fkhfiv Hvjkodv jnbkj kod pnb~jktipx gpkmnripc io kwkhjk`hjhtxig hogipmkthio/

61/ Pn{~hpnmnotv ho tln T~pcv kod Fkhfiv Hvjkodv ti pntkho pnjnwkot hogip-

mkthio ho pnvqnft ig fimqkohnv* qkptonpvlhqv kod tp~vtv kphvn jkpbnjx gpimtln jkrv biwnpohob tln gipmkthio kod pnbhvtpkthio ig tlnvn noththnv* kod kjviti k vhbohghfkot n|tnot tln T~pcv kod Fkhfiv Hvjkodv Koth-Mionx Jk~odnphob,KMJ( pnbhmn kqqjhfk`jn ti tln ghokofhkj `~vhonvvnv qpiwhdhob fipqipktnvnpwhfnv ti tlnm/ Tln i`jhbkthiov hmqivnd `x itl vntv ig jkrv kpn v~gghfhnotti mnnt mivt ig tln pn{~hpnmnotv ~odnp tln hotnpokthiokj vtkodkpd/

6;/ Fnptkho fktnbiphnv ig qpignvvhiokj tp~vtnnv kpn n|nmqtnd gpim jhfnov-hob kod fippnvqiodhobjx tln i`jhbkthiov ig tln T~pcv kod Fkhfiv KMJ pnbhmn/Tln iojx i`jhbkthiov gip v~fl tp~vtnnv ti lkwn hogipmkthio io tln hdnothtx

ig vnttjipv kod `nonghfhkphnv vtnm gpim fimmio jkr/ Ht hv oit fjnkp rlntlnp


18/70


;7 FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO

tlnvn i`jhbkthiov mnnt tln TiP K/; g~jjx/ Nvvnothkj njnmnot K/; hv tlnpngipngi~od ti n ho qjkfn* rhtl fnptkho kvqnftv ig htv jnbkj hmqjnmnotkthio pn{~hphobhmqpiwnmnot/

60/ Tln pn{~hpnmnotv ~odnp tln T~pcv kod Fkhfiv Hvjkodv jkrv ho pnvqnftig kffi~othob pnfipdv di oit mnnt tln vtkodkpd dnvfph`nd ho njnmnot K/0 ig tln TiP/ Rlhjn fimqkohnv* qkptonpvlhqv kod tp~vtnnv kpn bnonpkjjx pn{~hpndti cnnq ~q-ti-dktn pnfipdv tlkt pngjnft tlnhp ghokofhkj kggkhpv* tlnvn i`jhbkthiovkpn oit v~gghfhnotjx fimqpnlnovhwn ho tnpmv ig vfiqn kod dntkhj3 kod di oithofj~dn ~odnpjxhob dif~mnotkthio/ Tln T~pcv kod Fkhfiv Hvjkodv KMJ pnbhmnpn{~hpnv ghokofhkj `~vhonvvnv ti pntkho fimqpnlnovhwn tpkovkfthiokj hogipmk-thio ho pnvqnft ig tlnhp fipqipktn fjhnotv* `~t tlnvn i`jhbkthiov kqqjx iojx ti tlnv~`vnt ig `~vhonvv tpkovkfthiov tlkt kpn mkdn tlpi~bl pnb~jktnd noththnv/ >

66/ Ho pnvqnft ig kocv kod itlnp ghokofhkj hovtht~thiov* tln kqqjhfkthio ig tln KMJ pnbhmn ti tlnvn noththnv nov~pnv tlkt kjj pnjnwkot pnfipdv qnptkhohobti f~vtimnpv kffi~otv kv rnjj kv pnjktnd ghokofhkj kod tpkovkfthio hogipmk-thio kpn kwkhjk`jn/

64/ Ho bnonpkj* rlnpn ko i`jhbkthio n|hvtv ho tln T~pcv kod Fkhfiv Hvjkodvgip pnjnwkot pnfipdv ti `n cnqt* tlnpn kpn nogipfnmnot qpiwhvhiov v~fl kv ghonvip hmqphviomnot ho qjkfn ti dhvfi~pkbn oio-fimqjhkofn/ Tln nggnfthwnonvvig tlnvn nogipfnmnot qpiwhvhiov rhjj `n fiovhdnpnd kv qkpt ig tln T~pcv kodFkhfiv Hvjkodv Qlkvn 0 pnwhnr/

K/;/ Ironpvlhq kod hdnothtx hogipmkthio

E~phvdhfthiov vli~jd nov~pn tlkt ironpvlhq kod hdnothtx hogipmkthio gip kjj pnjnwkotnoththnv kod kppkobnmnotv hv kwkhjk`jn ti tlnhp fimqntnot k~tliphthnv/

Fimqkohnv ,TiP 7 K/;/;(

6>/ Tln T~pcv kod Fkhfiv Fimqkohnv Ipdhokofn kjjirv tln hofipqipkthiokod pnbhvtpkthio ig tri qphmkpx fjkvvnv ig fimqkohnv ipdhokpx fimqkohnv

kod N|nmqtnd Fimqkohnv ,NFv(/ @itl txqnv ig fimqkohnv mkx lkwn tlnhp jhk`hjhthnv `n ~ojhmhtnd* ip `n jhmhtnd `x vlkpnv ip b~kpkotnn/

67/ Ko ipdhokpx fimqkox hv k fimqkox rlhfl fiod~ftv k v~`vtkothkj qkpt ig htv `~vhonvv ho tln T~pcv kod Fkhfiv Hvjkodv kod hv v~`enft ti kjj ig

>/ Tln T~pcv kod Fkhfiv Hvjkodv lkv kmnodnd tln Fimqkohnv Ipdhokofn kod tlnJhmhtnd Qkptonpvlhqv Ipdhokofn ti mnnt tln pnfimmnodkthiov ig tln kvvnvvipv~odnp njnmnot K/0/ Tlnvn kmnodmnotv rhjj fimn hoti gipfn io 08 E~jx 01;;/

7/ Tnpmv ig Pngnpnofn ti Miohtip kod Pnwhnr Qpibpnvv Tirkpdv Tpkovqkpnofx kodN|flkobn ig Hogipmkthio


19/70


FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO ;2

tln qpiwhvhiov ig tln jkrv pnjkthob ti fimqkohnv/ Ko NF hv k fimqkox rlivn `~vhonvv kfthwhthnv kpn fiod~ftnd v~`vtkothkjjx i~tvhdn ig tln T~pcv kodFkhfiv Hvjkodv/ Ht fko iojx nvvnothkjjx lijd k `koc kffi~ot ip iro ip jnkvnigghfn ho tln T~pcv kod Fkhfiv Hvjkodv `~t itlnprhvn hv qpilh`htnd gpim fio-d~fthob `~vhonvv kfthwhthnv ho tln T~pcv kod Fkhfiv Hvjkodv2/

62/ NFv kpn n|nmqtnd gpim kox tk| ip d~tx jnwhnd io qpightv ip hofimnip io fkqhtkj kvvntv* bkhov ip kqqpnfhkthiov kod kox v~fl tk| ho tln okt~pnig nvtktn d~tx ip holnphtkofn tk|* qkxk`jn io tln vlkpnv* dn`not~pnv ip itlnp i`jhbkthiov ig k fimqkox gip k qnphid ig 01 xnkpv gpim tln dktn ig htv hofipqi-pkthio/ Tlnx kpn kjvi v~`enft ti gnrnp pnb~jkthiov tlko ipdhokpx fimqkohnv 1 xnkpv/ Tln pnfipd cnnqhob pn{~hpnmnotv kqqjhfk jn tiNFv kqqjx vhmhjkpjx ti NFv tlkt kpn pnbhvtnpnd kv JJFv/

Fimqkox ironpvlhq kod hdnothtx hogipmkthio pn{~hpnd ti `n qpiwhdnd ti biwnpomnot k~tliphthnv

41/ Tln Pnbhvtpkp ig Fimqkohnv hv qkpt ig tln Ghokofhkj Vnpwhfnv Fimmhv-vhio kod hv pn{~hpnd ~odnp tln Fimqkohnv Ipdhokofn ti mkhotkho ~odnp kqqpi-

qphktn fiodhthiov kjj dif~mnotv kod qkqnpv jidbnd rhtl lhm/ Tlhv hofj~dnv kpnbhvtnp ig kjj fimqkohnv pnbhvtnpnd ~odnp tln Fimqkohnv Ipdhokofn/ Kjj T~pcvkod Fkhfiv fimqkohnv m~vt pnbhvtnp kod qpiwhdn tlnhp mnmipkod~m kod kpth-fjnv ig kvvifhkthio ti tln Pnbhvtpkp kt tln thmn ig tlnhp hofipqipkthio/

2/ Vnfthio ;


20/70


;< FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO

4;/ Tln mnmipkod~m ig kvvifhkthio m~vt fiotkho dntkhjv kv vnt i~t `njir5

Fimqkox jhmhtnd xvlkpnv

Fimqkox jhmhtnd xb~kpkotnn ^ojhmhtnd fimqkox

Okmn ig qpiqivndfimqkox



Vtktnmnot tlkt tlnpnbhvtnpnd igghfn hv rhtlhotln T~pcv kod FkhfivHvjkodv* kod tln kddpnvv

Vtktnmnot tlkt tlnpnbhvtnpnd igghfn hv rhtlhotln T~pcv kod FkhfivHvjkodv* kod tln kddpnvv

Kddpnvv ig tlnpnbhvtnpnd igghfn

K dnfjkpkthio tlkt tlnjhk`hjhtx ig tln mnm`npvhv jhmhtnd

K dnfjkpkthio tlkt nkflmnm`np ~odnptkcnv tifiotph`~tn ti tln kvvntv

ig tln fimqkox ~odnp pnjnwkot fhpf~mvtkofnv

K dnfjkpkthio tlkt tlnjhk`hjhtx ig tln mnm`npvhv ~ojhmhtnd

Dntkhjv io tln oimhokjfkqhtkj rhtl rlhfl tlnfimqkox qpiqivnv ti `npnbhvtnpnd

40/ Nwnpx mnmipkod~m ig kvvifhkthio m~vt `n vhbond `x nwnpx v~`vfph`np*rli hv pn{~hpnd ti hodhfktn lhv okmn* kddpnvv* iff~qkthio* kod* ho tln fkvn ig kfimqkox jhmhtnd `x vlkpnv* tln kmi~ot ig vlkpnv ln tkcnv ;1 / Tlnvn dntkhjv kpn

notnpnd hoti tln pnbhvtnp ig fimqkohnv `x tln Pnbhvtpkp iofn tln mnmipkod~m hvv~`mhttnd/

46/ Kgtnp hofipqipkthio* k fimqkox jhmhtnd `x vlkpnv hv pn{~hpnd ti v~`mhtti tln Pnbhvtpkp io k koo~kj `kvhv ko ~qdktnd jhvt fiotkhohob tln okmn* kddpnvv*iff~qkthio kod vlkpnlijdhob ig nkfl vlkpnlijdnp ;; / Ho kddhthio* hg tln fimqkoxlkv mipn tlko ^VD ;1 111 ho pnbhvtnpnd oimhokj fkqhtkj* kox flkobn ti tlnvlkpnlijdhobv ig tln fimqkox ip ig tln mnm`npv d~phob tln fi~pvn ig tln xnkp m~vt `n kdwhvnd ti tln Pnbhvtpkp rhtlho 61 dkxv ig tln flkobn lkqqnohob/ ;0

44/ Tln vkmn pn{~hpnmnotv bnonpkjjx kqqjx ti NFv rhtl tln pnvqnfthwnfkqhtkj vtp~ft~pnv;6 * n|fnqt tlkt NFv kpn oit i`jhbnd ~odnp tln FimqkohnvIpdhokofn ti v~`mht ip ~qdktn ti tln Pnbhvtpkp kox hogipmkthio io tlnhp vlkpnlijdnpv ip mnm`npv* rlntlnp kt tln qihot ig pnbhvtpkthio ip v~`vn{~notjx/

;1/ Vnfthio ;; ig tln Fimqkohnv Ipdhokofn/;;/ Vnfthio 68 ig tln Fimqkohnv Ipdhokofn/;0/ Vnfthio 68,0( ig tln Fimqkohnv Ipdhokofn/;6/ Vnfthio ;


21/70


FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO ;8

Gipnhbo fimqkohnv

4>/ K gipnhbo-hofipqipktnd fimqkox mkx kqqjx ti `n fiotho~nd kv kT~pcv kod Fkhfiv hofipqipktnd NF hg tln jkrv ig tln fi~otpx ig htv hofipqipk-

thio di oit qpilh`ht tlhv/ ^qio pnbhvtpkthio kv ko NF* tln fimqkox hv v~`enftti tln vkmn qpiwhvhiov kqqjhfk jn ti NFv/

47/ Itlnprhvn* k gipnhbo-hofipqipktnd fimqkox tlkt fkpphnv io k `~vhonvvho tln T~pcv kod Fkhfiv Hvjkodv hv dnghond ti `n gipnhbo fimqkox ~odnp v012ig tln Fimqkohnv Ipdhokofn kod m~vt pnbhvtnp rhtl tln Pnbhvtpkp ig Fimqkohnvrhtlho 61 dkxv ig gkjjhob ~odnp tlkt dnghohthio/ Tln Fimqkohnv Ipdhokofndnghonv tln tnpm fkppxhob io `~vhonvv bnonpkjjx kod tlhv vli~jd fiwnp fkvnvrlnpn tln `~vhonvv kfthwhthnv ig k gipnhbo fimqkox kpn nggnfthwnjx mkokbndgpim tln T~pcv kod Fkhfiv Hvjkodv* kod rlnpn tlnvn kfthwhthnv kpn vhbohghfkot

noi~bl ti bhwn phvn ti k qnpmkonot nvtk`jhvlmnot* lkd tlnx iff~ppnd ho k tk|hob e~phvdhfthio/ Ho ipdnp ti `n pnbhvtnpnd* tln gipnhbo fimqkox m~vt ghjn fnptkhohogipmkthio rhtl tln Pnbhvtpkp* hofj~dhob5

fiqhnv ig htv mnmipkod~m kod kpthfjnv ig kvvifhkthio3

okmnv kod kddpnvvnv ig qnpviov pnvhdnot ho tln T~pcv kod Fkhfivk~tliphvnd ti kffnqt io htv `nlkjg vnpwhfn ig qpifnvv kod kox oithfnvpn{~hpnd ti `n vnpwnd io ht3 kod

g~jj okmn* kddpnvv kod iff~qkthio ig nkfl ig tln dhpnftipv ig tlnfimqkox/

42/ Kox flkobnv ti tln mnmipkod~m kod kpthfjnv ig kvvifhkthio* ip tlnokmnv ip kddpnvvnv ig qnpviov k~tliphvnd ti kffnqt vnpwhfn io htv `nlkjg m~vt

`n kdwhvnd ti tln Pnbhvtpkp rhtlho 0; dkxv ig tln thmn kt rlhfl hogipmkthio ig v~fl flkobnv ri~jd lkwn `nno pnkviok`jx pnfnhwnd ho tln T~pcv kod Fkhfiv/Tln gipnhbo fimqkox hv oit pn{~hpnd ti v~`mht ti tln Pnbhvtpkp kox hogipmk-thio pnjkthob ti htv jnbkj ip `nonghfhkj ironpv/

4


22/70


01 FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO

okmn* kddpnvv kod iff~qkthio ig kjj mnm`npv3

tln dktn tln qnpvio rkv notnpnd io tln pnbhvtnp kv* ip fnkvnd ti `n* kmnm`np3 kod

ho tln fkvn ig k fimqkox jhmhtnd `x vlkpnv* k vtktnmnot ig tln o~m`np ig vlkpnv lnjd `x nkfl mnm`np* dhvthob~hvlhob* vkwn ho tln fkvn ig vlkpnv tlkt kpn g~jjx qkhd* nkfl vlkpn `x htv o~m`np* kod ig tln kmi~ot

qkhd* ip kbpnnd ti `n fiovhdnpnd qkhd* io tln vlkpnv ig nkfl mnm`np/

>1/ Ho tln fkvn ig `nkpnp vlkpnv k fimqkox rhjj iojx onnd ti mkhotkhoho tln pnbhvtnp tln o~m`np ig v~fl vlkpnv* tln dktn ig tlnhp hvv~n* tlnhp pngnp-nofn o~m`np ,hg kqqjhfk`jn( kod tln gkft tlkt tlnvn vlkpnv kpn hvv~nd ti `nkpnp/Hogipmkthio io tlnhp `nonghfhkj ironpv hv ti `n lnjd `x tln fimqkox mkokbnp*kbnot ip vnfpntkpx ,vnn vnfthio io `nkpnp vlkpnv `njir(/

>;/ Tln pnbhvtnp m~vt `n cnqt kt tln fimqkoxv pnbhvtnpnd igghfn* vkwn hotln fkvn ig NFv* rlhfl kpn kjjirnd ti cnnq ht kt koitlnp jifkthio kv jiob kv kfnpthghnd tp~n fiqx ig tln pnbhvtnp hv cnqt ho htv pnbhvtnpnd igghfn kod flkobnvmkdn ti tln pnbhvtnp kpn notnpnd io tln fnpthghnd fiqx oit jktnp tlko ion rnnc gpim tln dktn ig tln iff~ppnofn ig tln flkobn/

>0/ Tln k`iwn i`jhbkthiov kqqjx ti kjj fimqkohnv* rlhfl kpn dnghond~odnp Vnfthio 0 ig tln Fimqkohnv Ipdhokofn ti hofj~dn kjj fimqkohnv gipmnd kod pnbhvtnpnd ~odnp tln Fimqkohnv Ipdhokofn/ Tlhv ri~jd fjnkpjx hofj~dnipdhokpx fimqkohnv* NFv kod gipnhbo fimqkohnv fiotho~nd kv NFv ho tlnT~pcv kod Fkhfiv Hvjkodv/

>6/ Ht hv oit fjnkp rlntlnp tlhv dnghohthio fiwnpv gipnhbo fimqkohnv tlktkpn hohthkjjx gipmnd i~tvhdn ig tln T~pcv kod Fkhfiv Hvjkodv* `~t v~`vn{~notjxpnbhvtnpnd tlnpn `nfk~vn tlnx fkppx io k `~vhonvv tlnpn/ Tlhv hv k pnjnwkothvv~n nfk~vn tln ironpvlhq hogipmkthio ig pnjnwkot gipnhbo fimqkohnv ,tlivnnggnfthwnjx mkokbnd kod lkwhob k qnpmkonot nvtk`jhvlmnot ho tln T~pcvkod Fkhfiv Hvjkodv( hv mkdn kwkhjk`jn tlpi~bl tlhv pn{~hpnmnot ~odnp tlnFimqkohnv Ipdhokofn/ Tln T~pcv kod Fkhfiv Hvjkodv k~tliphthnv lkwn kdwhvndtlkt htv hotnpqpntkthio ig tln dnghohthio ig fimqkohnv hofj~dnv v~fl gipnhbo

fimqkohnv3 tlnpngipn v~fl gipnhbo fimqkohnv kpn kjvi i`jhbnd ti mkhotkho kpnbhvtnp ig tlnhp mnm`npv/ Kffipdhob ti tln T~pcv kod Fkhfiv Hvjkodv k~tliph-thnv* tlhv lkv kjvi `nno tln qpkfthfn vi gkp/

>4/ Kv tln jkr hv oit g~jjx fjnkp ho tlhv pnbkpd* ht hv pnfimmnodnd tlkt tlnT~pcv kod Fkhfiv Hvjkodv kmnod htv jnbhvjkthio ti fjkphgx tlkt tln i`jhbkthioti mkhotkho k pnbhvtnp ig mnm`npv kjvi kqqjhnv ti gipnhbo fimqkohnv hofipqi-pktnd i~tvhdn tln T~pcv kod Fkhfiv Hvjkodv* `~t pnbhvtnpnd tlnpn/ Rlntlnp tlnf~ppnot ~ofnptkhotx lkv bhwno phvn ti kox qpkfthfkj hvv~nv rhjj `n n|kmhond hotln fi~pvn ig tln T~pcv kod Fkhfiv Hvjkodv Qlkvn 0 pnwhnr/


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FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO 0;

Oimhonn hdnothtx hogipmkthio

>>/ K oimhonn tlkt kftv kv k jnbkj ironp ig kvvntv `x rkx ig `~vhonvvgkjjv rhtlho tln dnghohthio ig `~vhonvv ig fimqkox mkokbnmnot ~odnp tln

Fimqkox Mkokbnmnot ,Jhfnovhob( Ipdhokofn kod m~vt `n jhfnovnd ~odnp tln Ipdhokofn `ngipn ht fko qpiwhdn v~fl vnpwhfnv io k fimmnpfhkj `kvhv/

>7/ Kv lijdnpv ig pnb~jktipx jhfnovnv* v~fl oimhonnv kpn ghokofhkj `~vhonvvnv kv dnghond ~odnp Vflnd~jn 0 ig tln Koth-Mionx Jk~odnphob kodQpnwnothio ig Tnppiphvt Ghokofhob Pnb~jkthiov 01;1 kod kpn v~`enft ti tln pnj-nwkot KMJ pnb~jkthiov tlkt kqqjx ti kjj ghokofhkj `~vhonvvnv ho tln T~pcv kodFkhfiv Hvjkodv/ Tlnhp i`jhbkthio ti i`tkho hdnothtx hogipmkthio ig tln ironpvrlivn `nlkjg io rlhfl tlnx kft vtnmv gpim tlnvn pnb~jkthiov/

>2/ Kv rhtl itlnp vnpwhfn qpiwhdnpv* oimhonnv kpn pn{~hpnd ti fkppx i~tpnjnwkot f~vtimnp d~n dhjhbnofn mnkv~pnv ~odnp tln gijjirhob fhpf~mvtkofnv ;4 5

`ngipn tln ghokofhkj `~vhonvv nvtk`jhvlnv k `~vhonvv pnjkthiovlhq ip fkpphnv i~t ko iffkvhiokj tpkovkfthio3

rlnpn tln ghokofhkj `~vhonvv -

- V~vqnftv mionx jk~odnphob ip tnppiphvt ghokofhob3 ip

- di~`tv tln wnpkfhtx ip kdn{~kfx ig dif~mnotv* dktk ip hogipmk-thio qpnwhi~vjx i`tkhond ~odnp htv f~vtimnp d~n dhjhbnofn mnkv-~pnv ip rlno fiod~fthob iobihob miohtiphob3 kod

kt itlnp kqqpiqphktn thmnv ti n|hvthob f~vtimnpv kv dntnpmhon io kphvc-vnovhthwn `kvhv/

>8/ K oimhonn tlkt hv oit kfthob `x rkx ig `~vhonvv hv oit v~`enft ti tlnKMJ pnb~jkthiov/ Ht hv oit fjnkp rlntlnp v~fl oimhonnv* rli ri~jd fimqphvn

qphmkphjx ig qnpviov qnpgipmhob vnpwhfnv bpkt~hti~vjx ip ho tln fi~pvn ig k q~pnjx qphwktn oio-`~vhonvv pnjkthiovlhq* kpn vhbohghfkot ho tnpmv ig o~m- `npv kod tln kvvntv tlnx lijd/ Tln T~pcv kod Fkhfiv Hvjkodv k~tliphthnv lkwnkdwhvnd tlkt tlnpn kpn oi coiro ip pnqiptnd hovtkofnv ig oimhonnv kfthobho k qphwktn ip bpkt~hti~v fkqkfhtx rhtlho tln T~pcv kod Fkhfiv Hvjkodv/ Tln

;4/ Pnb~jkthio ;; ig tln Koth-Mionx Jk~odnphob kod Qpnwnothio ig Tnppiphvt GhokofhobPnb~jkthiov 01;1 dnvfph`nv tln hovtkofnv ~odnp rlhfl ghokofhkj `~vhonvvnv kpnpn{~hpnd ti fiod~ft f~vtimnp d~n dhjhbnofn mnkv~pnv/


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FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO 06

rhtl k whnr ti nhtlnp nolkofhob tln hmmi`hjhukthio pnbhmn rhtl pnvqnft ti `nkpnp vlkpnv ip qpilh`hthob tlnm kjtibntlnp/

@~vhonvv Jhfnovnv74/ Kox qnpvio rli fkpphnv io k `~vhonvv ho ip gpim rhtlho tln T~pcvkod Fkhfiv Hvjkodv gip tln q~pqivn ig bkho m~vt kqqjx gip k `~vhonvv jhfnovn~odnp tln @~vhonvv Jhfnovhob Ipdhokofn/ NFv kod ~vhonvvnv tlkt kpn kjpnkdxjhfnovnd ~odnp koitlnp Ipdhokofn kpn n|nmqtnd gpim tlhv pn{~hpnmnot ;7 /

7>/ Kt tln thmn ig kqqjhfkthio* `~vhonvvnv m~vt qpiwhdn tln @~vhonvvJhfnovhob Fimmhttnn rhtl tln okmnv ig tln `~vhonvv ironpv* rlhfl ho tlnfkvn ig k qkptonpvlhq ri~jd fimqphvn tln qkptonpv/ Ho tln fkvn ig k fimqkoxtln okmnv ig tln dhpnftipv ri~jd v~gghfn/

77/ Kox flkobnv ti tln qkpthf~jkpv qpiwhdnd kt tln thmn ig kqqjhfkthiom~vt `n kdwhvnd ti tln @~vhonvv Jhfnovhob Fimmhttnn rhtlho 61 dkxv ig v~flflkobn iff~pphob/ Ho kddhthio* k fimqkox m~vt oithgx tln Fimmhttnn rhtlho61 dkxv ig kox flkobn ho tln qnpviov rli lkwn k fiotpijjhob hotnpnvt ho tlnfimqkox/

Qkptonpvlhqv ,TiP K/;/6(

72/ T~pcv kod Fkhfiv jkrv kjjir tln gipmkthio ig tlpnn fjkvvnv ig qkpt-

onpvlhqv Bnonpkj Qkptonpvlhqv ,BQv(* Jhmhtnd Qkptonpvlhqv ,JQv( kodN|nmqtnd Jhmhtnd Qkptonpvlhqv ,NJQv(/

Bnonpkj Qkptonpvlhqv

7


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FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO 0>

JQv kod NJQv

24/ Kjj JQv* hofj~dhob NJQv* m~vt pnbhvtnp tlnmvnjwnv rhtl tln Pnbhvtpkp ig Fimqkohnv kod kt tln qihot ig pnbhvtpkthio qpiwhdn qkpthf~jkpv ig tln JQ*

vthq~jkthob5tln ghpm okmn3

tln bnonpkj okt~pn ig tln ghpmv `~vhonvv3

kddpnvv ho tln T~pcv kod Fkhfiv Hvjkodv ig htv pnbhvtnpnd igghfn3

tln tnpm* hg kox* gip rlhfl tln JQ hv notnpnd hoti* ip hg gip ko ~ojhm-htnd d~pkthio* k vtktnmnot ti tlkt nggnft kod tln dktn ig fimmnofn-mnot3 kod

tln g~jj okmn kod kddpnvv ig nkfl bnonpkj qkptonp/;8

2>/ Hg k bnonpkj qkptonp hv k fipqipktn nothtx* k fnpthghfkthio ig htv hofipqipkthio ip pnbhvtpkthio ~odnp tln Fimqkohnv Ipdhokofn m~vt kjvi `n qpi-whdnd ti tln Pnbhvtpkp/ Tln JQ hv oit pn{~hpnd ti v~`mht ti tln Pnbhvtpkp ig Fimqkohnv hogipmkthio io tln hdnothtx ig tln jhmhtnd qkptonpv/ Kox flkobnvho tln k`iwn qkpthf~jkpv m~vt `n kdwhvnd ti tln Pnbhvtpkp rhtlho ;> dkxv ig tlnflkobn/ Hg k bnonpkj qkptonp fnkvnv ti `n k bnonpkj qkptonp* tlhv oithghfkthio

qnphid hv vliptnond ti vnwno dkxv/ 01

27/ Tln Pnbhvtpkp hv pn{~hpnd ti mkhotkho hogipmkthio io nkfl jhmhtnd

qkptonpvlhq kod v~fl pnfipdv kpn iqno ti q~`jhf hovqnfthio d~phob igghfnli~pv/ Tln Jhmhtnd Qkptonpvlhq Kft dinv oit vthq~jktn lir jiob tlnvn pnfipdvm~vt `n cnqt `x tln Pnbhvtpkp* `~t tln T~pcv kod Fkhfiv Hvjkodv k~tliphthnvlkwn kdwhvnd tlkt kjj fipqipktn ghjhobv kpn mkhotkhond gip ;1 xnkpv kgtnp tlndktn tlkt ko nothtx hv vtp~fc ip pnmiwnd gpim tln pnbhvtnp/

Ironpvlhq kod hdnothtx hogipmkthio pn{~hpnd ti `n lnjd `x qkptonpvlhqv


22/ Tlnpn hv oi n|qjhfht jnbkj i`jhbkthio gip BQv ti mkhotkho ironpvlhqkod hdnothtx hogipmkthio ig htv qkptonpv/ Lirnwnp* tln i`jhbkthio gip BQv tlktfkppx io k `~vhonvv ho tln T~pcv kod Fkhfiv Hvjkodv ti pnbhvtnp kod v~qqjxtln @~vhonvv Jhfnovhob Fimmhttnn rhtl tln okmnv ig kjj tln qkptonpv* kvrnjj kv ti pnqipt kox v~`vn{~not flkobnv ho tlhv hogipmkthio ti tln @~vhonvv

;8/ Vnfthio 2 ig tln Jhmhtnd Qkptonpvlhqv Ipdhokofn/01/ Vnfthio < ig tln Jhmhtnd Qkptonpvlhqv Ipdhokofn/


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Jhfnovhob Fimmhttnn rhtlho 61 dkxv ig tln flkobn iff~pphob ,vnn k`iwn(*fpnktnv ko hmqjhfht i`jhbkthio gip k BQ ti lkwn tln hdnoththnv ig kjj tln qkptonpv/

JQv kod NJQv2


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0< FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO

Vnfpntkpx* Ghokofn kqqpiwnv ti `n k e~phvdhfthio tlkt kdn{~ktnjxpnb~jktnv kod v~qnpwhvnv tp~vt fimqkohnv*

ip

- k fimqkox rlhfl kftv kv k `kpn tp~vtnn iojx* tlkt hv rlhfl mnpnjxlijdv qpiqnptx io tp~vt rhtl oi hotnpnvt ho ip d~tx kv ti tp~vt qpiq-nptx* n|fnqt ti fiownx ht rlno dhpnftnd `x tln `nonghfhkj ironp/


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Vnpwhfn qpiwhdnpv

81/ Tln KMJ pnbhmn kqqjhfk jn ti vnpwhfn qpiwhdnpv hv ko hmqiptkotnjnmnot ho tln T~pcv kod Fkhfiv Hvjkodv k`hjhtx ti nov~pn tln kwkhjk`hjhtx ig

hogipmkthio fiofnpohob tln hdnothtx kod `nonghfhkj ironpvlhq ig jnbkj qnpviovkod kppkobnmnotv/ Kjtli~bl ht hv oit i jhbktipx gip jnbkj qnpviov kod kppkobn-mnotv ho tln T~pcv kod Fkhfiv Hvjkodv ti nobkbn tln vnpwhfnv ig k jhfnovndvnpwhfn qpiwhdnp* mivt qnpviov fiod~fthob `~vhonvv ho ip gpim rhtlho tlnT~pcv kod Fkhfiv Hvjkodv rhjj lkwn vimn howijwnmnot rhtl k vnpwhfn qpiwhdnp tlpi~bl nhtlnp k ion-igg tpkovkfthio ip ko iobihob `~vhonvv pnjkthiovlhq/N|kmqjnv ri~jd hofj~dn ko NF tlkt nobkbnv tln vnpwhfnv ig k fimqkox mko-kbnp ti qpiwhdn k pnbhvtnpnd igghfn ho tln T~pcv kod Fkhfiv Hvjkodv* k fimqkoxtlkt nmqjixv k jhfnovnd kbnot gip fimqkox gipmkthio vnpwhfnv* ip k tp~vt tlktnobkbnv tln vnpwhfnv ig k T~pcv kod Fkhfiv qpignvvhiokj tp~vtnn/ Ht hv tlpi~bltlnvn hovtkofnv tlkt tln f~vtimnp d~n dhjhbnofn mnkv~pnv ~odnp tln KMJpnbhmn rhjj `n tphbbnpnd kod tln ironpvlhq hogipmkthio ig pnjnwkot noththnv

`n mkdn kwkhjk jn/

8;/ Tln Koth-Mionx Jk~odnphob kod Qpnwnothio ig Tnppiphvt ghokofhobPnb~jkthiov 01;1* hvv~nd ~odnp tln Qpifnndv ig Fphmn Ipdhokofn 0112* hvtln pnjnwkot jnbhvjkthio pnb~jkthob tln KMJ i`jhbkthiov ig vnpwhfn qpiwhdnpvho tln T~pcv kod Fkhfiv Hvjkodv/ Ht hv kqqjhfk jn ti k fimqpnlnovhwn pkobn ig ghokofhkj `~vhonvvnv rhtlho tln T~pcv kod Fkhfiv Hvjkodv* rlhfl hofj~dnvpnb~jktnd jhfnovnnv v~fl kv `kocv* qpignvvhiokj tp~vtnnv* g~od mkokbnpv* fim-

qkox mkokbnpv* hownvtmnot dnkjnpv* hov~pnpv* mionx tpkovmhttnpv* kv rnjj kvvnpwhfn qpiwhdnpv tlkt di oit pn{~hpn k pnb~jktipx jhfnovn* v~fl kv kffi~otkotvkod mionx `picnpv 06/ Tln Pnb~jkthiov kpn v~qqjnmnotnd `x tln Koth-MionxJk~odnphob kod Qpnwnothio ig Tnppiphvt Ghokofhob Fidn 0112 ,Fidn(*rlhfl vntv i~t ho dntkhj tln vfiqn kod txqn ig mnkv~pnv ghokofhkj `~vhonvvnvkpn pn{~hpnd ti ~odnptkcn ho ipdnp ti mnnt tlnhp KMJ i`jhbkthiov/

80/ ^odnp tln Pnb~jkthiov* ghokofhkj ~vhonvvnv kpn qpilh`htnd gpim vntthob~q ip mkhotkhohob kox koioxmi~v kffi~otv ,Pnb~jkthio ;7(/ Kddhthiokjjx* tlnxkpn i`jhbnd ti fiod~ft kqqpiqphktn f~vtimnp d~n dhjhbnofn mnkv~pnv ~odnp tlngijjirhob fhpf~mvtkofnv5

`ngipn fimmnofhob k `~vhonvv pnjkthiovlhq rhtl k onr fjhnot3

`ngipn fkppxhob i~t ko iffkvhiokj tpkovkfthio ,dnghond kv k tpkovkf-thio ip k vnphnv ig jhocnd tpkovkfthiov tlkt howijwn kt jnkvt ^VD ; 111ho tln fkvn ig k mionx vnpwhfnv `~vhonvv* ip ^VD ;> 111 ho itlnp fkvnv( rlnpn tln tpkovkfthio hv oit fkpphnd i~t kv qkpt ig ko n|hvthob

`~vhonvv pnjkthiovlhq3

06/ Tln `~vhonvvnv fiwnpnd `x tln KMJ pnb~jkthiov kpn jhvtnd ho Vflnd~jnv ; kod 0 ig tlnKoth-Mionx Jk~odnphob kod Qpnwnothio ig Tnppiphvt Ghokofhob Pnb~jkthiov 01;1/


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rlnpn tln ghokofhkj `~vhonvv v~vqnftv mionx jk~odnphob ip tnppiphvtghokofhob* ip di~`tv tln wnpkfhtx ig dif~mnotv nkpjhnp i`tkhond3 kod

gip n|hvthob fjhnotv* kt kqqpiqphktn thmnv ~vhob k phvc-`kvnd kqqpikfl/

86/ F~vtimnp d~n dhjhbnofn mnkv~pnv hofj~dn i tkhohob hogipmkthio iotln `nonghfhkj ironpv ig fjhnotv kod kox tlhpd qkpthnv* kod wnphgxhob v~flhogipmkthio io tln `kvhv ig dif~mnotv* dktk ip hogipmkthio i`tkhond gpim kpnjhk`jn kod hodnqnodnot vi~pfn/

84/ Ghokofhkj `~vhonvvnv fko fliivn ti pnjx io ko njhbh jn hotpid~fnp tifiod~ft tlnvn mnkv~pnv3 tlhv fiothobnot io v~fl hotpid~fnpv `nhob KMJ-pnb~jktnd noththnv tlnmvnjwnv/ Ti di vi ghokofhkj `~vhonvvnv m~vt i`tkho kvtktnmnot gpim v~fl hotpid~fnpv tlkt tln hotpid~fnp htvnjg lkv kqqjhnd tln pnj-nwkot f~vtimnp d~n dhjhbnofn mnkv~pnv kod rhjj tpkovmht hdnothtx hogipmkthio

io tln fjhnotv ti tln ghokofhkj `~vhonvv ~qio pn{~nvt/ Tln ghokofhkj `~vhonvvpnmkhov jhk`jn gip kox gkhj~pn ti kqqjx tlnvn mnkv~pnv/04

8>/ Rlno vnpwhfn qpiwhdnpv kpn pn{~hpnd ti fiod~ft f~vtimnp d~ndhjhbnofn mnkv~pnv* tlnx kpn i`jhbnd ti cnnq tln gijjirhob hogipmkthio gip k mhohm~m qnphid ig ghwn xnkpv gpim tln dktn io rlhfl tln tpkovkfthio hvfimqjntnd ip rlno tln `~vhonvv pnjkthiovlhq nodv5

v~qqipthob dif~mnotv* dktk ip hogipmkthio tlkt lkwn `nno i`tkhondho pnvqnft ig k `~vhonvv pnjkthiovlhq ip iffkvhiokj tpkovkfthiorlhfl hv tln v~`enft ig f~vtimnp d~n dhjhbnofn mnkv~pnv ip iobihobmiohtiphob3

k pnfipd fiotkhohob dntkhjv pnjkthob ti nkfl tpkovkfthio fkpphnd i~t `xtln ghokofhkj `~vhonvv ho tln fi~pvn ig kox `~vhonvv pnjkthiovlhq ip iffkvhiokj tpkovkfthio3 kod

kjj kffi~ot ghjnv3 kod kjj `~vhonvv fippnvqiodnofn pnjkthob ti k `~vh-onvv pnjkthiovlhq ip ko iffkvhiokj tpkovkfthio/

87/ Tln GVF ip Pnqipthob K~tliphtx nvtk`jhvlnd ~odnp tln Pnb~jkthiovmkx kt tlnhp dhvfpnthio vqnfhgx k jiobnp hogipmkthio pntnothio qnphid/

Nogipfnmnot qpiwhvhiov ti nov~pn kwkhjk`hjhtx ig hogipmkthio,TiP K/;/7(

82/ Tln n|hvtnofn ig kqqpiqphktn qnokjthnv gip oio-fimqjhkofn rhtl cnxi`jhbkthiov hv ko hmqiptkot tiij gip e~phvdhfthiov ti nggnfthwnjx nogipfn tlni jhbkthiov ti pntkho hdnothtx kod ironpvlhq hogipmkthio/ Oio-fimqjhkofnkggnftv rlntlnp tln hogipmkthio hv kwkhjk`jn ti tln T~pcv kod Fkhfiv Hvjkodv

04/ Pnb~jkthio ;4 ig tln KMJ pnb~jkthiov/


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FIMQJHKOFN RHTL TLN VTKODKPDV5 KWKHJK@HJHTX IG HOGIPMKTHIO 6;

ti pnvqiod ti k pn{~nvt gip hogipmkthio `x htv NIH qkptonpv ho kffipdkofn rhtltln hotnpokthiokj vtkodkpd/

8 gip nwnpx dkx d~phob rlhfl tln dngk~jt fiotho~nv3

k fimqkox tlkt gkhjv ti giprkpd ko koo~kj jhvt ig htv vlkpnlijdnpvtln Pnbhvtpkp hv jhk`jn ti k ghon ig ^VD 6>1 gip nwnpx dkx tln dngk~jt

fiotho~nv3 rhtl tln ghon kjvi kqqjhfk`jn ti nwnpx igghfnp* dhpnftip ip vnfpntkpx ig tln fimqkox rli rhjg~jjx k~tliphvnv v~fl k dngk~jt3 0>

k ghokofhkj `~vhonvv tlkt gkhjv ti ~odnptkcn kqqpiqphktn f~vtimnp d~ndhjhbnofn mnkv~pnv hv jhk jn ti k ghon ig ~q ti ^VD >1 111 ~qio v~m-mkpx fiowhfthio gip k pnb~jktnd ghokofhkj `~vhonvv kod ^VD > 111 gip k oio-pnb~jktnd ghokofhkj `~vhonvv307

nwnpx ghokofhkj `~vhonvv hv i`jhbnd ti kqqihot k mionx jk~odnphobfimqjhkofn igghfnp kqqpiwnd `x tln pnjnwkot v~qnpwhvipx k~tliphtx*rlivn pijn hv ti iwnpvnn kod nov~pn tln ghokofhkj `~vhonvv fimqjh-

kofn rhtl tln KMJ pn{~hpnmnotv/ Gkhj~pn ti fimqjx kttpkftv k ghon ig ~q ti ^VD 0> 111 ~qio v~mmkpx fiowhfthio3 02

gkhj~pn `x tln bnonpkj qkptonp,v( ig k JQ ip NJQ ti mkhotkho k pnbhvtnp ig tln okmn kod kddpnvv* kmi~ot kod dktn ig fiotph`~thio)pnt~po ig fiotph`~thio ig nkfl qkptonp fkpphnv k ghon ig ^VD >11 ~qio fiowhf-thio gip nkfl bnonpkj qkptonp* kod k g~ptlnp ghon ig ^VD >1 gip nkfldkx tln dngk~jt fiotho~nv3 kod 0/ Vnfthio 41 ig tln Fimqkohnv Ipdhokofn/07/ Pnb~jkthio ;; ig tln KMJ pnb~jkthiov/02/ Pnb~jkthio 0; ig tln KMJ pnb~jkthiov/0


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;11/ Tln nggnfthwnonvv ig tln nogipfnmnot qpiwhvhiov rlhfl kpn ho qjkfn hotln T~pcv kod Fkhfiv Hvjkodv rhjj `n n|kmhond kv qkpt ig htv Qlkvn 0 pnwhnr/

Dntnpmhokthio kod gkftipv ~odnpjxhob pnfimmnodkthiov

Qlkvn ; dntnpmhokthio

Tln njnmnot hv ho qjkfn* `~t fnptkho kvqnftv ig tln jnbkj hmqjnmnotkthioig tln njnmnot onnd hmqpiwnmnot /

Gkftipv ~odnpjxhobpnfimmnodkthiov Pnfimmnodkthiov

Ht hv oit fjnkp tlkt tln i`jhbkthio timkhotkho k pnbhvtnp ig vlkpnlijdnpvkqqjhnv ti kjj pnjnwkot gipnhbo fimqk-

ohnv tlkt kpn nggnfthwnjx mkokbnd kodlkwn k qnpmkonot nvtk`jhvlmnot hotln T~pcv kod Fkhfiv Hvjkodv/

Tln T~pcv kod Fkhfiv Hvjkodv vli~jdkmnod htv jnbhvjkthio ti fjkphgx tlkt tlni`jhbkthio ti mkhotkho k pnbhvtnp ig mnm-

`npv kjvi kqqjhnv kjj pnjnwkot gipnhbofimqkohnv tlkt kpn nggnfthwnjx mkokbndkod lkwn k qnpmkonot nvtk`jhvlmnot hotln T~pcv kod Fkhfiv Hvjkodv/

Qpignvvhiokj tp~vtnnv tlkt mnnt tlnfiodhthiov gip jhfnovhob n|nmqthio dioit lkwn fjnkp i`jhbkthiov ti mkhotkhotln hdnothtx ig tln vnttjipv kod `nongh-fhkphnv ig tln tp~vtv gip rlim tlnx kftkv tp~vtnn/ Tlnx kpn iojx v~`enft ti

fimmio jkr pn{~hpnmnotv kod ht hv oitfjnkp tlkt v~fl pn{~hpnmnotv nov~pnhdnothtx hogipmkthio io tln vnttjipv kod`nonghfhkphnv hv kwkhjk`jn ti tln fim-qntnot k~tliphthnv/

Tln T~pcv kod Fkhfiv Hvjkodv vli~jdnov~pn tlkt kjj qpignvvhiokj tp~vtnnvcoir tln hdnothtx ig tln vnttjipv kod`nonghfhkphnv ig tln tp~vtv gip rlimtlnx qpiwhdn vnpwhfnv ti/

K/0/ Kffi~othob pnfipdv

E~phvdhfthiov vli~jd nov~pn tlkt pnjhk`jn kffi~othob pnfipdv kpn cnqt gip kjj

pnjnwkot noththnv kod kppkobnmnotv/

Bnonpkj pn{~hpnmnotv ,TiP K/0/;(* ^odnpjxhob dif~mnotkthio,TiP K/0/0( kod >-xnkp pntnothio vtkodkpd ,TiP K/0/6(

;1;/ Tlnpn kpn oi i`jhbkthiov gip noththnv kod kppkobnmnotv ti mkhotkhokffi~othob pnfipdv gip tk| q~pqivnv kv tlnpn hv oi hofimn tk| pnbhmn ho tlnT~pcv kod Fkhfiv Hvjkodv/ Noththnv kod kppkobnmnotv kpn iojx pn{~hpnd ticnnq kffi~othob pnfipdv ti tln n|tnot qpiwhdnd gip ho tlnhp pnvqnfthwn pnb~jkt-hob Ipdhokofnv/ Tlhv hv v~qqjnmnotnd `x tln pnfipd cnnqhob pn{~hpnmnotvhmqivnd `x tln KMJ pnb~jkthiov io pnjnwkot vnpwhfn qpiwhdnpv/


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Kffi~othob pnfipdv ti `n cnqt ho pnvqnft ig fimqkohnv

;10/ Kjj fimqkohnv pnbhvtnpnd ~odnp tln Fimqkohnv Ipdhokofn* hofj~dhobNFv kod gipnhbo fimqkohnv* m~vt cnnq qpiqnp ìicv ig kffi~otv hofj~dhob

dkx ìicv ig kffi~ot kv ti bhwn k tp~n kod gkhp whnr ig tln vtktn ig tln fimqkoxv kggkhpv kod ti n|qjkho htv tpkovkfthiov/08 V~fl hogipmkthio hofj~dnv5

kjj v~mv ig mionx pnfnhwnd kod n|qnodnd `x tln fimqkox kod tlnmkttnp ho pnvqnft ig rlhfl tln pnfnhqt kod n|qnodht~pn tkcn qjkfn3

kjj vkjnv kod q~pflkvnv ig biidv `x tln fimqkox3 kod

tln kvvntv kod jhk`hjhthnv ig tln fimqkox

;16/ Ht hv oit fjnkp rlntlnp tlnvn i`jhbkthiov hofj~dn mkhotkhohob ~odnpjx-hob dif~mnotkthio qnptkhohob ti tln fimqkoxv tpkovkfthiov v~fl kv fiotpkftvkod howihfnv/;14/ Tln Fimqkohnv Ipdhokofn dinv oit vqnfhgx kox thmn qnphid gip tlnpntnothio ig kffi~othob pnfipdv/

Kffi~othob pnfipdv ti `n cnqt `x vnpwhfn qpiwhdnpv)ghokofhkj `~vhonvvnv

;1>/ Tln Koth-Mionx Jk~odnphob kod Qpnwnothio ig Tnppiphvt GhokofhobPnb~jkthiov 01;1 pn{~hpnv ghokofhkj `~vhonvvnv61 ti cnnq ho pnvqnft ig nwnpx tpkov-

kfthio fiod~ftnd tlpi~bl tlnm5v~qqipthob dif~mnotv* dktk ip hogipmkthio tlkt lkwn `nno i`tkhond hopnvqnft ig k `~vhonvv pnjkthiovlhq ip iffkvhiokj tpkovkfthio rlhfl hvtln v~ènft ig f~vtimnp d~n dhjhbnofn mnkv~pnv ip iobihob miohtiphob3



;17/ V~fl pnfipdv m~vt hofj~dn v~gghfhnot hogipmkthio ti nok`jn tln pnfio-vtp~fthio ig hodhwhd~kj tpkovkfthiov* kod m~vt `n cnqt gip k mhohm~m qnphidig > xnkpv/ Gkhj~pn ti fimqjx kttpkftv k ghon ig ~q ti ^VD >1 111 ~qio v~m-mkpx fiowhfthio/

08/ Vnfthio >2 ig tln Fimqkohnv Ipdhokofn61/ Tln pnfipd pntnothio i`jhbkthiov ig ghokofhkj `~vhonvvnv hv fiwnpnd ~odnp

Pnb~jkthio ;


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;12/ Rlhjn fimqpnlnovhwn* ht vli~jd `n oitnd tlkt tlnvn pn{~hpnmnotvkqqjx iojx ti tln v~`vnt ig `~vhonvv tpkovkfthiov tlkt kpn mkdn tlpi~bl pnb~-jktnd noththnv/ Vhofn jnbkj qnpviov kod kppkobnmnotv ho tln T~pcv kod Fkhfivkpn ~odnp oi i`jhbkthio ti nobkbn tln vnpwhfnv ig pnb~jktnd noththnv gip kjjtlnhp tpkovkfthiov* tln pnfipd pntnothio pn{~hpnmnotv ~odnp tln T~pcv kodFkhfiv Hvjkodv KMJ pnbhmn rhjj oit `n v~gghfhnot ti fiwnp kjj pnjnwkot jnbkj

qnpviov kod kppkobnmnotv kod tlnpngipn tln pn{~hpnmnotv ig TiP K/;/0/

Kffi~othob pnfipdv ti `n cnqt ho pnvqnft ig qkptonpvlhqv


;1


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;;4/ @kocv kpn i`jhbnd ti cnnq tln gijjirhob pnfipdv io f~vtimnpv kodtpkovkfthiov645

k fiqx ig tln nwhdnofn ig hdnothtx i`tkhond q~pv~kot ti tln kqqjhfkthio

ig f~vtimnp d~n dhjhbnofn mnkv~pnv ip iobihob miohtiphob* ip hogip-mkthio tlkt nok`jnv k fiqx ig v~fl nwhdnofn ti `n i`tkhond3

tln v~qqipt dif~mnotv* dktk ip hogipmkthio tlkt lkwn `nno i`tkhondho pnvqnft ig k `~vhonvv pnjkthiovlhq ip iffkvhiokj tpkovkfthio rlhfl hvtln v~`enft ig f~vtimnp d~n dhjhbnofn mnkv~pnv ip iobihob miohtiphob3



;;>/ V~fl pnfipdv m~vt `n cnqt gip k mhohm~m ghwn xnkpv gpim tln dktntln tpkovkfthio hv fimqjntnd ip tln `~vhonvv pnjkthiovlhq nodv/ Gkhj~pn ti divi kttpkftv k ghon ig ~q ti ^VD >1 111 ~qio v~mmkpx fiowhfthio/



Tln njnmnot hv ho qjkfn/

64/ Pnb~jkthio ;< ig tln KMJ Pnb~jkthiov


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FIMQJHKOFN RHTL TLN VTKODKPDV5 KFFNVV TI HOGIPMKTHIO 62

@/ Kffnvv ti Hogipmkthio

Iwnpwhnr

;;7/ K wkphntx ig hogipmkthio mkx `n onndnd ho pnvqnft ig tln kdmhohvtpkthiokod nogipfnmnot ig pnjnwkot tk| jkrv kod e~phvdhfthiov vli~jd lkwn tln k~tlip-htx ti kffnvv kjj v~fl hogipmkthio/ Tlhv hofj~dnv hogipmkthio lnjd `x `kocv koditlnp ghokofhkj hovtht~thiov kv rnjj kv hogipmkthio fiofnpohob tln ironpvlhq ig fimqkohnv ip tln hdnothtx ig hotnpnvt lijdnpv ho itlnp qnpviov ip noththnv/ Tlhvvnfthio ig tln pnqipt n|kmhonv rlntlnp tln T~pcv kod Fkhfiv Hvjkodv jnbkj kodpnb~jktipx gpkmnripc bhwnv ti htv fimqntnot k~tliphtx kffnvv qirnpv tlkt fiwnp kjj pnjnwkot qnpviov kod hogipmkthio* kod rlntlnp tln phbltv kod vkgnb~kpdv tlktkpn ho qjkfn kpn fimqkth`jn rhtl nggnfthwn n|flkobn ig hogipmkthio/

;;2/ Tln T~pcv kod Fkhfiv Hvjkodv Qnpmkonot Vnfpntkpx* Ghokofn hv tlnfimqntnot k~tliphtx gip T~pcv kod Fkhfiv THNKv* kod lkv tln pnjnwkot hogip-mkthio bktlnphob qirnpv ~odnp tln Tk| Hogipmkthio N|flkobn Ipdhokofn,THN Ipdhokofn(/ Ln mkx n|npfhvn tlnvn qirnpv lhmvnjg ip dnvhboktn koitlnp

qnpvio ti di vi io lhv `nlkjg/

;;


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6< FIMQJHKOFN RHTL TLN VTKODKPDV5 KFFNVV TI HOGIPMKTHIO

;01/ Rlhjn fioghdnothkjhtx p~jnv kqqjx ti hogipmkthio i`tkhond `x qpignv-vhiokj qnpviov ho tln fi~pvn ig tlnhp `~vhonvv pnjkthiovlhqv* tlnvn p~jnv bnonp-kjjx di oit qpnwnot nggnfthwn NIH/ Pnjnwkot n|fnqthiov kpn kwkhjk`jn gip tlnfimqntnot k~tliphtx ti n|npfhvn lhv hogipmkthio bktlnphob qirnpv ti fimqjxrhtl ko NIH pn{~nvt/ Ho kddhthio* tln THN Ipdhokofn qpiwhdnv tlkt kox qnpvio

qpiwhdhob fioghdnothkj hogipmkthio gip tln q~pqivnv ig k pn{~nvt vlkjj lkwnk`vij~tn dngnofn ti kox fioghdnothkjhtx i`jhbkthio/

@/;/ Fimqntnot k~tliphtxv k`hjhtx ti i`tkho kod qpiwhdn hogipmkthio

Fimqntnot k~tliphthnv vli~jd lkwn tln qirnp ti i`tkho kod qpiwhdn hogipmkthio tlkt hv tlnv~`enft ig k pn{~nvt ~odnp ko n|flkobn ig hogipmkthio kppkobnmnot gpim kox qnpvio rhtlhotlnhp tnpphtiphkj e~phvdhfthio rli hv ho qivvnvvhio ip fiotpij ig v~fl hogipmkthio ,hppnvqnfthwnig kox jnbkj i`jhbkthio io v~fl qnpvio ti mkhotkho tln vnfpnfx ig tln hogipmkthio(/

Ironpvlhq kod hdnothtx hogipmkthio ,TiP @/;/;( kod Kffi~othob pnfipdv ,TiP @/;/0/(

;0;/ Tln fimqntnot k~tliphtxv qirnpv ti kffnvv ironpvlhq kod hdnothtxhogipmkthio kpn gi~od ho tln T~pcv kod Fkhfiv THN Ipdhokofn/ Gip tln q~p-

qivnv ig fimqjxhob rhtl ko NIH pn{~nvt* tln fimqntnot k~tliphtx mkx* `xoithfn ho rphthob* pn{~hpn kox qnpvio ti qpiwhdn v~fl hogipmkthio kv mkx `nvqnfhghnd ho tln oithfn/ Tlhv hv v~`enft ti tri fiodhthiov S nmqlkvhv kddnd ]*rlhfl kpn tlkt5

tln qnpvio hv pnkviok`jx `njhnwnd ti lkwn tln hogipmkthio ti rlhfltln oithfn pnjktnv3 kod

tln hogipmkthio pn{~nvt hv -

- Hogipmkthio lnjd `x k `koc ip itlnp ghokofhkj hovtht~thio* ip kox qnpvio kfthob ho ko kbnofx ip ghd~fhkpx fkqkfhtx* hofj~dhob koimhonn ip tp~vtnn3 ip

- Hogipmkthio pnbkpdhob tln `nonghfhkj ironpvlhq ig k fimqkox* qkptonpvlhq ip itlnp qnpvio/

;00/ Tlnvn qirnpv kpn qitnothkjjx dnghfhnot ho tri kpnkv3 tln ghpvt ho tlkttlnx kqqnkp ti iojx kjjir tln fimqntnot k~tliphtx ti i`tkho hogipmkthio tlkthv lnjd `x k qnpvio rhtlho tln T~pcv kod Fkhfiv Hvjkodv kod oit hogipmkthiorlhfl hv fiotpijjnd `~t oit lnjd `x k qnpvio rhtlho T~pcv kod Fkhfiv tnpphti-phkj e~phvdhfthio/ Tln hotnpokthiokj vtkodkpd pn{~hpnv e~phvdhfthiov ti i`tkhokod n|flkobn hogipmkthio ho tln jkttnp vfnokphi kv rnjj/ Tlhv hv vqnjt i~tho Qkpkbpkql 2 ig tln Fimmnotkpx ti tln INFD Midnj THNK* rlhfl iojxpnjhnwnv k pn{~nvtnd Vtktnv i`jhbkthio ti i`tkho kod n|flkobn hogipmkthio


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rlhfl hv onhtlnp lnjd `x htv k~tliphthnv oip hv ho tln qivvnvvhio ip fiotpij ig qnpvio rhtlho htv tnpphtiphkj e~phvdhfthio/

;06/ Tln T~pcv kod Fkhfiv Hvjkodv k~tliphthnv lkwn kdwhvnd tlkt tln tnpm

lkwn dinv oit lkwn k pnvtphftnd mnkohob kod kffipdhob ti htv hotnpqpntk-thio ri~jd hofj~dn k qnpvio rli lkv fiotpij ig hogipmkthio lnjd n|tpk-tnpphtiphkjjx/ Oi pnfimmnodkthio lkv nno bhwno ho whnr ig tlhv fjkphghfkthio/Rlntlnp tlhv lkv `nno ko hvv~n ho qpkfthfn rhjj `n n|kmhond ho tln fi~pvn ig tln T~pcv kod Fkhfiv Hvjkodv Qlkvn 0 pnwhnr/

;04/ Tln vnfiod kod mipn hmqiptkot dnghfhnofx jhnv ho tln gkft tlkt iotln gkfn ig ht tln jnbhvjkthio kqqnkpv ti kjjir tln fimqntnot k~tliphtx ti iojxpn{~nvt hogipmkthio tlkt hv lnjd `x fnptkho dnghond noththnv ,`kocv* ghd~fhkphnv*ntf/( ip rlhfl pnjktnv ti tln `nonghfhkj ironpvlhq ip k fimqkox* qkptonpvlhq ip itlnp qnpvio/

;0>/ Tlhv ri~jd oit `n fiovhvtnot rhtl tln hotnpokthiokj vtkodkpd* rlhflpn{~hpnv tln n|flkobn ig kjj hogipmkthio gipnvnnk`jx pnjnwkot ti tln kdmhohv-tpkthio kod nogipfnmnot ig tln dimnvthf tk| jkrv ig tln pn{~nvthob e~phvdhfthio/Tlhv hv oit jhmhtnd ti `nonghfhkj ironpvlhq ig jnbkj qnpviov kod kppkobnmnotv/Tlhv hv fjkphghnd ho Qkpkbpkql 42 ig tln Fimmnotkpx ti tln INFD MidnjTHNK* rlhfl n|qjkhov ho pnvqnft ig Kpthfjn > ,qkpnotlnvhv kddnd( tlkt5 V~`-

qkpkbpkql k( ,rlhfl pngnpv ti k e~phvdhfthiov i`jhbkthio ti n|flkobn ironp-vlhq kod hdnothtx hogipmkthio( vli~jd oit `n tkcno ti v~bbnvt tlkt k fimqntnot k~tliphtx hv i`jhbnd iojx ti lkwn tln k~tliphtx ti i`tkho kod qpiwhdn hogipmk-thio gpim tln qnpviov mnothiond /;07/ Tln T~pcv kod Fkhfiv Hvjkodv k~tliphthnv tkcn tln whnr tlkt tlnx lkwng~jj kffnvv qirnpv ti i`tkho g~jj hogipmkthio gpim kjj noththnv io tln gijjir-hob kvhv5

tln q~pqivn ig nokfthob tln THN Ipdhokofn rkv ti fimqjx rhtl tlntnpmv ig tln T~pcv kod Fkhfiv Hvjkodv THNKv3

kjj THNKv kpn hmqjnmnotnd `x rkx ig k vflnd~jn ti tln THNIpdhokofn kod tlnpngipn `nfimn jkr/ Tln THNKv tlnmvnjwnv i jhbn

tln T~pcv kod Fkhfiv Hvjkodv ti n|flkobn kjj hogipmkthio gipnvnnk`jxpnjnwkot ti tln nogipfnmnot ig tln dimnvthf tk| jkrv ig tln pn{~nvthob qkptx/ Tln kffnvv qirnpv kpn oit pnvtphftnd 6>3 kod

tln ripdv ghd~fhkpx kod kbnot nofimqkvv tln d~thnv ig k dhpnftip ti k fimqkox 67* kod k bnonpkj qkptonp ti k qkptonpvlhq/

;02/ Ho bnonpkj* tln THNKv tlnmvnjwnv di oit fiotkho k qpiwhvhio nmqir-nphob k fiotpkfthob qkptx ti i tkho hogipmkthio/ Ht mnpnjx q~tv tln i`jhbkthio

6>/ P w Flhng Hmmhbpkthio Igghfnp* Lnktlpir Khpqipt ' Koip* n| qkptn Vkjkmkt @h`h/67/ Pnbkj ,Lkvthobv( Jhmhtnd w/ B~jjhwnp kod Itlnpv LJ)QI)E^)4)6)826/


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41 FIMQJHKOFN RHTL TLN VTKODKPDV5 KFFNVV TI HOGIPMKTHIO

io tln fiotpkfthob qkpthnv ti i`tkho kod n|flkobn tln hogipmkthio* `~t dinvoit qpiwhdn kox kffnvv qirnpv ti tln T~pcv kod Fkhfiv k~tliphthnv/ Tln jkttnp onndv ti `n qpiwhdnd gip vnqkpktnjx* rlhfl hv ho gkft rlkt tln T~pcv kodFkhfiv Hvjkodv lkv dion tlpi~bl vnfthio >,;( ig tln THN Ipdhokofn/

;0 ig tln THN Ipdhokofnpn{~hphob k qnpvio ti qpid~fn tln vqnfhghnd pnjnwkot hogipmkthio/ Tln oithfnrhjj vqnfhgx tln thmngpkmn gip fimqjhkofn ,~v~kjjx 0< dkxv(* kod hg onfnvvkpx*tln gipm ho rlhfl tln hogipmkthio hv ti `n qpid~fnd kv rnjj kv tln mkoonp ho rlhfl ht hv ti `n wnphghnd ip k~tlnothfktnd/ Gkhj~pn ti fimqjx rhtl tlnoithfn gip hogipmkthio fkpphnv ~qio v~mmkpx fiowhfthio k ghon oit n|fnndhob^VD ;1 111 kod)ip hmqphviomnot gip k tnpm oit n|fnndhob tri xnkpv/

;60/ Tln fimqntnot k~tliphtx mkx kqqjx ti k Mkbhvtpktn gip k vnkpfl rkppkot hg5

k pnfhqhnot ig k oithfn gkhjv ti fimqjx ip iojx qkptjx fimqjhnv rhtltln oithfn3 ip

tln fimqntnot k~tliphtx hv ig tln iqhohio tlkt tln oithfn gip hogipmkthiorhjj oit `n fimqjhnd rhtl ip htv hvv~kofn rhjj fk~vn tln dif~mnotv ip hogipmkthio ti rlhfl tln oithfn pnjktnv ti `n pnmiwnd* tkmqnpnd rhtlip dnvtpixnd/

62/ Tln T~pcv kod Fkhfiv Hvjkodv lkv kmnodnd tln THN Ipdhokofn 0118 ti mnnt tlnpnfimmnodkthiov ig tln kvvnvvipv fiofnpohob pnvtphfthiov io tln k`hjhtx ig tlnfimqntnot k~tliphtx ti kffnvv hogipmkthio gip NIH q~pqivnv/ Tln kmnodmnotfkmn hoti gipfn io ;> E~jx 01;;/


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FIMQJHKOFN RHTL TLN VTKODKPDV5 KFFNVV TI HOGIPMKTHIO 4;

;66/ K fnpthghfktn bhwno `x tln fimqntnot k~tliphtx tlkt tln hvv~n ig kvnkpfl rkppkot hv pn{~hpnd gip tln q~pqivnv ig fimqjxhob rhtl k pn{~nvt hv v~g-ghfhnot k~tliphtx gip tln hvv~n ig tln vnkpfl rkppkot rhtli~t g~ptlnp ho{~hpx/

;64/ K vnkpfl rkppkot k~tliphvnv k fimqntnot k~tliphtxv pnqpnvnotkthwn*tibntlnp rhtl k qijhfn igghfnp* ti5

notnp tln qpnmhvnv vqnfhghnd ho tln rkppkot kt kox thmn rhtlho ionmiotl gpim tln dktn ig tln rkppkot3

vnkpfl tln qpnmhvnv kod tkcn qivvnvvhio ig kox hogipmkthio kqqnkp-hob ti `n hogipmkthio ig k txqn ho pnvqnft ig rlhfl tln rkppkot rkvhvv~nd ip ti tkcn ho pnjkthio ti v~fl hogipmkthio* kox itlnp vtnqvrlhfl kqqnkp ti `n onfnvvkpx gip qpnvnpwhob ip qpnwnothob hotnpgnp-nofn rhtl tlnm3

tkcn fiqhnv ig* ip n|tpkftv gpim* kox hogipmkthio kqqnkphob ti `nhogipmkthio ig k txqn ho pnvqnft ig rlhfl tln rkppkot rkv hvv~nd3

pn{~hpn kox qnpvio io tln qpnmhvnv ti qpiwhdn ko n|qjkokthio ig koxhogipmkthio kqqnkphob ti `n hogipmkthio ig k txqn ig rlhfl tln rkp-pkot rkv hvv~nd ip ti vtktn rlnpn v~fl hogipmkthio mkx `n gi~od3 kod

~vn v~fl gipfn kv mkx `n pnkviok`jx onfnvvkpx ti n|nf~tn tln rkppkot/

Vnfpnfx qpiwhvhiov ,TiP @/;/>(

Bnonpkj vnfpnfx qpiwhvhiov

;6>/ Tln Fioghdnothkj Pnjkthiovlhqv Ipdhokofn ,FPI( hv tln bnonpkj jkrbiwnpohob tln dhvfjiv~pn ig fioghdnothkj hogipmkthio kf{~hpnd `x qpignvvhiokj

qnpviov ho tln fi~pvn ig tlnhp `~vhonvv/ Fioghdnothkj hogipmkthio hv `pikdjxdnghond kod hofj~dnv kjj hogipmkthio fiofnpohob kox qpiqnptx kod fimmnp-fhkj tpkovkfthiov rlhfl lkwn tkcno ip mkx tkcn qjkfn* rlhfl tln pnfhqhnot hvoit* itlnprhvn tlko ho tln oipmkj fi~pvn ig `~vhonvv ip qpignvvhiokj qpkfthfn*k~tliphvnd `x tln qphofhqkj ti dhw~jbn/ Tln qpignvvhiokj qnpviov fiwnpnd

hofj~dn kffi~otkotv* kttiponxv* `picnpv* fimmnpfhkj kbnotv* `kocv* kod biw-npomnot igghfhkjv/

;67/ Tln FPI mkcnv ht ko iggnofn gip lijdnpv ig fioghdnothkj hogipmkthioti dhvfjivn ip tlpnktno ti dhvfjivn v~fl hogipmkthio ti ~ok~tliphvnd qnpviov/Ht dinv lirnwnp qpiwhdn n|fnqthiov ti tlhv p~jn ~odnp fnptkho fhpf~mvtkofnv*v~fl kv rlno pnjnwkot biwnpomnot k~tliphthnv pn{~hpn tln hogipmkthio gip tln

q~pqivnv ig fiod~fthob hownvthbkthiov* ip rlno koitlnp Ipdhokofn n|qpnvvjx qnpmhtv v~fl dhvfjiv~pn/ Tlhv n|fnqthio hv pnjnwkot kod kjjirv tln fimqntnotk~tliphtx ti n|npfhvn lhv hogipmkthio bktlnphob qirnpv gip NIH q~pqivnv

~odnp tln THN Ipdhokofn/


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;62/ Kvhdn gpim tln FPI* fioghdnothkjhtx qpiwhvhiov kjvi kqqjx ti tln biw-npomnot pnb~jktipv ig m~t~kj g~odv* tp~vtnnv `~vhonvvnv* kocv kod fimqkoxmkokbnpv/ Tlnvn pn{~hpnmnotv fko `n gi~od ho tln pnvqnfthwn ipdhokofnvpnb~jkthob tlnvn vnpwhfn qpiwhdnpv* kod hmqivn ko i`jhbkthio ~qio tln pnb~jk-tipv ti mkhotkho fioghdnothkjhtx ig tln hogipmkthio tlnx i`tkho ho tln fi~pvnig tlnhp pnb~jktipx ripc 6


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fimm~ohfkthiov `ntrnno k qpignvvhiokj jnbkj kdwhvnp kod lhv fjhnotip kox qnpvio pnqpnvnothob lhv fjhnot ip `ntrnno v~fl ko kdwhvnp ip lhv fjhnot ip kox v~fl pnqpnvnotkthwn kod kox itlnp qnpvio mkdn hofioonfthio rhtl ip ho fiotnmqjkthio ig jnbkj qpifnndhobv kod gip tln

q~pqivnv ig v~fl qpifnndhobv3 kod

mktnphkj nofjivnd rhtl ip pngnppnd ti ho v~fl fimm~ohfkthiov kodmkdn

- ho fioonfthio rhtl tln bhwhob ig jnbkj kdwhfn* ip

- ho fioonfthio rhtl ip ho fiotnmqjkthio ig jnbkj qpifnndhobv kodgip tln q~pqivnv ig v~fl qpifnndhobv/

;4;/ Tlhv hv fiovhvtnot rhtl tln hotnpokthiokj vtkodkpd/

Fiofj~vhio

;40/ Ho v~mmkpx* tln T~pcv kod Fkhfiv fimqntnot k~tliphtxv qirnpv tii`tkho kod qpiwhdn hogipmkthio ti htv NIH qkptonpv kpn fimqjhkot rhtl vimnig tln pn{~hpnmnotv ~odnp TiP @/;/; kod @/;/0 Lirnwnp* vliptfimhobv ho tlnT~pcv kod Fkhfiv Hvjkodv jnbhvjkthio jhmht tln vfiqn ig hogipmkthio tln fim-

qntnot k~tliphtx hv k~tliphvnd ti i tkho3 tlhv mkx pnvtphft htv k`hjhtx ti mnnt tlntnpmv ig htv THNKv ~odnp fnptkho fhpf~mvtkofnv/



Tln njnmnot hv oit ho qjkfn /


Tln qirnpv ig tln T~pcv kod FkhfivHvjkodv fimqntnot k~tliphthnv tii`tkho kod n|flkobn hogipmkthio~odnp ko hogipmkthio n|flkobnkbpnnmnot kqqjx iojx ti ,k(hogipmkthio lnjd `x k `koc ip itlnp ghokofhkj hovtht~thio* ip kox qnpviokfthob ho ko kbnofx ip ghd~fhkpxfkqkfhtx* hofj~dhob k oimhonn ip tp~vtnn* ip ,`( hogipmkthio tlkt pnjktnvti tln `nonghfhkj ironpvlhq ig kfimqkox* qkptonpvlhq ip itlnp qnpvio/

Tln T~pcv kod Fkhfiv Hvjkodv vli~jdnov~pn tlkt htv fimqntnot k~tliphtxlkv tln qirnp* gip tln q~pqivnv ig tk| hogipmkthio n|flkobn* ti i`tkhohogipmkthio gpim kox qnpvio tlktmkx `n ho qivvnvvhio ip fiotpijig hogipmkthio tlkt hv gipnvnnk`jxpnjnwkot ti tln kdmhohvtpkthio kodnogipfnmnot ig tln dimnvthf tk| jkrvig tln pn{~nvthob e~phvdhfthio/


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@/0/ Oithghfkthio pn{~hpnmnotv kod phbltv kod vkgnb~kpdv

Tln phbltv kod vkgnb~kpdv , n/b / oithghfkthio* kqqnkj phbltv( tlkt kqqjx ti qnpviov ho tlnpn{~nvtnd e~phvdhfthio vli~jd `n fimqkth`jn rhtl nggnfthwn n|flkobn ig hogipmkthio/

Oit ~od~jx qpnwnot ip dnjkx n|flkobn ig hogipmkthio ,TiP @/0/;(

;46/ Tlnpn hv oi pn{~hpnmnot ho tln T~pcv kod Fkhfiv Hvjkodv dimnvthfjnbhvjkthio tlkt tln tk|qkxnp ~odnp hownvthbkthio ip n|kmhokthio m~vt n bhwno

qphip oithghfkthio ig k pn{~nvt/

;44/ Tln fimqntnot k~tliphtx mkx kt htv dhvfpnthio oithgx tln KttiponxBnonpkj ig kox pn{~nvt3 tlhv oithghfkthio qpifnvv `nfimnv i`jhbktipx rlno tlnfimqntnot k~tliphtx hv ig tln whnr tlkt pn{~nvtnd hogipmkthio fiofnpov hvv~nv

ig q~`jhf qijhfx/;4>/ Ho fkvnv rlnpn tln fimqntnot k~tliphtx oithghnv tln Kttiponx Bnonpkjig kox pn{~nvt* tln Kttiponx Bnonpkj vlkjj `n nothtjnd* ho k mkoonp kokjibi~vti kmhf~v f~phkn68* ti kqqnkp ip ti tkcn qkpt ho kox qpifnndhobv ho tln T~pcvkod Fkhfiv Hvjkodv* rlntlnp e~dhfhkj ip kdmhohvtpkthwn* kphvhob dhpnftjx ip hodh-pnftjx gpim tln pn{~nvt/ Tln fimqntnot k~tliphtx vlkjj dnox k pn{~nvt rlnpntln Kttiponx Bnonpkj lkv hvv~nd k fnpthghfktn ti tln nggnft tlkt tln n|nf~thio ig tln pn{~nvt hv fiotpkpx ti tln q~`jhf qijhfx ig tln T~pcv kod Fkhfiv Hvjkodv/

;47/ Rlntlnp tln kdmhohvtpkthwn qpifnd~pn gip tln fimqntnot k~tliphtx tihogipm tln Kttiponx Bnonpkj ig fnptkho pn{~nvtv lkv ko hmqkft io nggnfthwnNIH vli~jd `n n|kmhond ho fjivnp dntkhj d~phob tln T~pcv kod Fkhfiv HvjkodvQlkvn 0 pnwhnr/



Tln njnmnot hv ho qjkfn/

68/ Jktho gip gphnod ig tln fi~pt/ Ht hv kdwhfn gipmkjjx iggnpnd ti tln fi~pt ho k phng ghjnd `x ko nothtx hotnpnvtnd ho* `~t oit k qkptx ti* tln fkvn/


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FIMQJHKOFN RHTL TLN VTKODKPDV5 N\FLKOBHOB HOGIPMKTHIO 4>

F/ N|flkobhob Hogipmkthio

Iwnpwhnr

;42/ E~phvdhfthiov bnonpkjjx fkooit n|flkobn hogipmkthio gip tk| q~pqivnv~ojnvv tlnx lkwn k jnbkj `kvhv ip mnflkohvm gip dihob vi/ Ho tln T~pcv kodFkhfiv Hvjkodv* tln jnbkj k~tliphtx ti n|flkobn hogipmkthio hv dnphwnd gpimTk| Hogipmkthio N|flkobn Kbpnnmnotv ,THNKv( kv rnjj kv gpim dimnvthfjkr/ Tlhv vnfthio n|kmhonv rlntlnp tln T~pcv kod Fkhfiv Hvjkodv lkv k ont-ripc ig hogipmkthio n|flkobn tlkt ri~jd kjjir ht ti kflhnwn nggnfthwn NIH ho

qpkfthfn/

;41/ Tln T~pcv kod Fkhfiv Hvjkodv THNKv nov~pn tlkt tln fiotpkfthob qkpthnv kpn oit i`jhbnd ti qpiwhdn hogipmkthio rlhfl ri~jd dhvfjivn tpkdn* `~vhonvv* hod~vtphkj* fimmnpfhkj ip qpignvvhiokj vnfpntv* hogipmkthio rlhfl hvtln v~`enft ig kttiponx-fjhnot qphwhjnbn ip ti mkcn dhvfjiv~pnv rlhfl ri~jd `nfiotpkpx ti q~ jhf qijhfx/ Tlnpn kpn oi jnbkj pnvtphfthiov io tln k`hjhtx ig tlnT~pcv kod Fkhfiv Hvjkodv fimqntnot k~tliphtx ti pnvqiod ti pn{~nvtv rhtlho

41/ Tln pnmkhohob tri kpn Gpkofn kod Qipt~bkj/


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47 FIMQJHKOFN RHTL TLN VTKODKPDV5 N\FLKOBHOB HOGIPMKTHIO

81 dkxv ig pnfnhqt `x qpiwhdhob tln hogipmkthio pn{~nvtnd ip `x qpiwhdhob ko~qdktn io tln vtkt~v ig tln pn{~nvt/

;>;/ Rlhjn tln T~pcv kod Fkhfiv Hvjkodv NIH kbpnnmnotv bnonpkjjx mnnt

tln hotnpokthiokj vtkodkpd* vliptfimhobv hdnothghnd ho Vnfthio @ ig tlhv pnqiptmnko tlkt tln T~pcv kod Fkhfiv Hvjkodv hv oit k`jn ti fimqjx g~jjx rhtl tlntnpmv ig tlnvn kbpnnmnotv/

F/;/ N|flkobn ig hogipmkthio mnflkohvmv

N|flkobn ig hogipmkthio mnflkohvmv vli~jd kjjir gip nggnfthwn n|flkobn ig hogipmkthio/

;>0/ Tln T~pcv kod Fkhfiv THNKv kpn bhwno tln gipfn ig jkr ho tln T~pcvkod Fkhfiv Hvjkodv tlpi~bl tln THN Ipdhokofn/ Gip k THNK ti `n bhwno jnbkjnggnft* tri fiodhthiov m~vt `n mnt5

tln THNK m~vt `n `pi~blt hoti gipfn ho kffipdkofn rhtl tln tnpmv ig tln THNK `x `itl fiotpkfthob e~phvdhfthiov3 kod

tln Biwnpoip m~vt qpiwhdn* `x Ipdnp ~odnp tln THN Ipdhokofn* tlkttln THN Ipdhokofn vlkjj kqqjx ti tln THNK/

;>6/ K THNK rlhfl hv mkdn nggnfthwn `x ko Ipdnp ~odnp tln THN Ipdh-okofn ri~jd gipm qkpt ig v~`vhdhkpx jnbhvjkthio kod ri~jd lkwn tln gipfn ig jkr* kod lkv n{~kj k~tliphtx ti kjj itlnp jkrv mkdn ho tln T~pcv kod FkhfivHvjkodv/ Kox fiogjhft `ntrnno tri jkrv ri~jd lkwn ti `n pnvijwnd `kvnd iotln p~jnv ig vtkt~tipx hotnpqpntkthio/ 4;

;>4/ Tln fimqntnot k~tliphtx ti pn{~nvt kod qpiwhdn hogipmkthio ~odnp tln T~pcv kod Fkhfiv Hvjkodv NIH kbpnnmnotv hv tln Qnpmkonot Vnfpntkpx*Ghokofn/

Gipnvnnk`jx pnjnwkot vtkodkpd ,TiP F/;/;(

;>>/ Tln hotnpokthiokj vtkodkpd gip n|flkobn ig hogipmkthio nowhvkbnv

hogipmkthio n|flkobn ti tln rhdnvt qivvh`jn n|tnot* `~t dinv oit kjjir vqnf~-jkthwn pn{~nvtv gip hogipmkthio tlkt lkwn oi kqqkpnot on|~v ti ko iqno ho{~hpxip hownvthbkthio/ Tln `kjkofn `ntrnno tlnvn tri fimqnthob fiovhdnpkthiov hvfkqt~pnd ho tln vtkodkpd ig gipnvnnk`jn pnjnwkofn/ Ht dinv oit kjjir ghvlhobn|qndhthiov/

;>7/ Kjj ig tln T~pcv kod Fkhfiv Hvjkodv THNKv qpiwhdn gip tln n|flkobn ig hogipmkthio tlkt hv gipnvnnk`jx pnjnwkot ti tln kdmhohvtpkthio kod nogipfnmnot

4;/ Tlhv ri~jd hofj~dn k dntnpmhokthio ig tln q~pqivn ig tln qpiwhvhio* rlhfl qpiwh-vhio rkv jktnp ho thmn* tln mnkohob ig tln qpiwhvhio ho htv fiotn|t* ntf/


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FIMQJHKOFN RHTL TLN VTKODKPDV5 N\FLKOBHOB HOGIPMKTHIO 42

ig tln dimnvthf jkrv ig tln Fiotpkfthob Qkpthnv fiofnpohob tk|nv fiwnpnd ho tlnTHNKv/ Tlhv vfiqn hv vnt i~t ho Kpthfjn ; ig kjj ig tln T~pcv kod Fkhfiv HvjkodvTHNKv/

;>2/ Tlnpn kpn lirnwnp jhmhtkthiov io tln n|flkobn ig qnpviokj dktk ho triig tln T~pcv kod Fkhfiv Hvjkodv THNKv/ Tln T~pcv kod Fkhfiv Hvjkodv Qpitifijvti htv THNKv rhtl tln Ontlnpjkodv ,Qkpkbpkql ;,d(( kod Bnpmkox ,Qkpkbpkql0,d(( fiotkho qpiwhvhiov pnvtphfthob tln n|flkobn ig qnpviokj dktk/ ^odnp tlnvn

qpiwhvhiov* kox kov io tln v~qqjx ig qnpviokj dktk qpnvfph`nd ~odnp tln jkr ig tln v~qqjxhob Fiotpkfthob Qkptx vlkjj `n i`vnpwnd* mnkohob tlkt v~fl dktkmkx oit `n n|flkobnd ~odnp kox fhpf~mvtkofnv/ Tln T~pcv kod Fkhfiv Hvjkodvk~tliphthnv lkwn kdwhvnd tlkt oi n|hvthob `ko hv kqqjhfk`jn ho tlhv pnbkpd/

;>8/ Tln pn{~hpnmnotv tlkt k fkvn m~vt n fiofpntn kod tlkt tlnpn m~vt n kvnphi~v qivvh`hjhtx kqqnkp ti `n mipn vtphobnot tlko tln vtkodkpd ig gipnvnnk`jxpnjnwkofn nowhvkbnd ~odnp tln hotnpokthiokj vtkodkpd/ Hodnnd* Qkpkbpkql 4 ig tlnfimmnotkpx ti tln INFD Midnj THNK vtktnv tlkt tln vtkodkpd ig gipnvnnk jn pnj-nwkofn hv mnkot ti nov~pn tlkt hogipmkthio pn{~nvtv mkx oit `n dnfjhond ho fkvnvrlnpn k dnghohtn kvvnvvmnot ig tln qnpthonofn ig tln hogipmkthio ti ko io-bihobhownvthbkthio fko iojx n mkdn gijjirhob tln pnfnhqt ig tln hogipmkthio/

;71/ Rlntlnp tln k`iwn pnvtphfthiov lkwn kox qpkfthfkj hmqkft io NIH rhjjn|kmhond ho tln fi~pvn ig tln T~pcv kod Fkhfiv Hvjkodv Qlkvn 0 pnwhnr/

Ho pnvqnft ig kjj qnpviov ,TiP F/;/0(

;7;/ Gip n|flkobn ig hogipmkthio ti `n nggnfthwn ht hv onfnvvkpx tlkt k e~phvdhfthiov i`jhbkthio ti qpiwhdn hogipmkthio hv oit pnvtphftnd `x tln pnvh-dnofn ip okthiokjhtx ig tln qnpvio ti rlim tln hogipmkthio pnjktnv ip `x tlnpnvhdnofn ip okthiokjhtx ig tln qnpvio ho qivvnvvhio ip fiotpij ig tln hogip-mkthio pn{~nvtnd/ Gip tlhv pnkvio tln hotnpokthiokj vtkodkpd gip n|flkobn ig hogipmkthio nowhvkbnv tlkt NIH mnflkohvmv rhjj qpiwhdn gip n|flkobn ig hogipmkthio ho pnvqnft ig kjj qnpviov/

;70/ Kjj ig tln T~pcv kod Fkhfiv Hvjkodv THNKv qpiwhdn gip NIH ho pnvqnft

ig kjj qnpviov/


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4< FIMQJHKOFN RHTL TLN VTKODKPDV5 N\FLKOBHOB HOGIPMKTHIO

N|flkobn ig hogipmkthio lnjd `x ghokofhkj hovtht~thiov* oimhonnv*kbnotv kod ironpvlhq kod hdnothtx hogipmkthio ,TiP F/;/6(

;76/ E~phvdhfthiov fkooit nobkbn ho nggnfthwn n|flkobn ig hogipmkthio hg

tlnx fkooit n|flkobn hogipmkthio lnjd `x ghokofhkj hovtht~thiov* oimhonnv ip qnpviov kfthob ho ko kbnofx ip k ghd~fhkpx fkqkfhtx/ @itl tln INFD MidnjTk| Fiownothio kod tln Midnj THNK* rlhfl kpn tln k~tliphtkthwn vi~pfnv ig tln vtkodkpdv* vthq~jktn tlkt `koc vnfpnfx fkooit gipm tln `kvhv gip dnfjhohobk pn{~nvt ti qpiwhdn hogipmkthio kod tlkt k pn{~nvt gip hogipmkthio fkooit `ndnfjhond vijnjx `nfk~vn tln hogipmkthio hv lnjd `x oimhonnv ip qnpviov kfthobho ko kbnofx ip ghd~fhkpx fkqkfhtx ip `nfk~vn tln hogipmkthio pnjktnv ti koironpvlhq hotnpnvt/

;74/ Kjj ig tln T~pcv kod Fkhfiv Hvjkodv THNKv qpiwhdn gip tln n|flkobnig hogipmkthio lnjd `x ghokofhkj hovtht~thiov* oimhonnv* kbnotv3 kod ironp-vlhq kod hdnothtx hogipmkthio/

K`vnofn ig dimnvthf tk| hotnpnvt ,TiP F/;/4(

;7>/ Tln fiofnqt ig dimnvthf tk| hotnpnvt dnvfph`nv k vht~kthio rlnpn kfiotpkfthob qkptx fko iojx qpiwhdn hogipmkthio ti koitlnp fiotpkfthob qkptxhg ht lkv ko hotnpnvt ho tln pn{~nvtnd hogipmkthio gip htv iro tk| q~pqivnv/ Kpng~vkj ti qpiwhdn hogipmkthio `kvnd io k dimnvthf tk| hotnpnvt pn{~hpnmnothv oit fiovhvtnot rhtl tln hotnpokthiokj vtkodkpd/ NIH qkptonpv m~vt `n k jn

ti ~vn tlnhp hogipmkthio bktlnphob mnkv~pnv nwno tli~bl howicnd vijnjx tii`tkho kod qpiwhdn hogipmkthio ti tln pn{~nvthob e~phvdhfthio/

;77/ Kjj ig tln T~pcv kod Fkhfiv Hvjkodv THNKv fiotkho qpiwhvhiov vhmhjkp ti tln Kpthfjn >,0( ig tln INFD Midnj THNK 40* rlhfl i`jhbnv tln FiotpkfthobQkpthnv ti ~vn tlnhp hogipmkthio bktlnphob mnkv~pnv ti i`tkho kod qpiwhdnhogipmkthio ti tln pn{~nvthob e~phvdhfthio nwno ho fkvnv rlnpn tln pn{~nvtndQkptx dinv oit lkwn k dimnvthf hotnpnvt ho tln pn{~nvtnd hogipmkthio/

K`vnofn ig d~kj fphmhokjhtx qphofhqjnv ,TiP F/;/>(

;72/ Tln qphofhqjn ig d~kj fphmhokjhtx qpiwhdnv tlkt kvvhvtkofn fko iojx `n qpiwhdnd hg tln fiod~ft `nhob hownvthbktnd ,kod bhwhob phvn ti ko hogipmkthiopn{~nvt( ri~jd fiovtht~tn k fphmn ~odnp tln jkrv ig tln pn{~nvtnd e~phvdhfthio

40/ Kpthfjn >,0( ig tln 0110 Midnj Kbpnnmnot pnkdv Hg tln hogipmkthio ho qivvnvvhioig tln fimqntnot k~tliphtx ig tln pn{~nvtnd Qkptx hv oit v~gghfhnot ti nok`jn ht tifimqjx rhtl tln pn{~nvt gip hogipmkthio* tlkt Qkptx vlkjj ~vn kjj pnjnwkot hogip-mkthio bktlnphob mnkv~pnv ti qpiwhdn tln kqqjhfkot Qkptx rhtl tln hogipmkthiopn{~nvtnd* oitrhtlvtkodhob tlkt tln pn{~nvtnd Qkptx mkx oit onnd v~fl hogipmk-thio gip ht irov tk| q~pqivnv


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FIMQJHKOFN RHTL TLN VTKODKPDV5 N\FLKOBHOB HOGIPMKTHIO 48

hg ht lkd iff~ppnd ho tln pn{~nvtnd e~phvdhfthio/ Ho ipdnp ti `n nggnfthwn*n|flkobn ig hogipmkthio vli~jd oit `n fiovtpkhond `x tln kqqjhfkthio ig tlnd~kj fphmhokjhtx qphofhqjn/

;7,;( ig tln INFD Midnj THNK 46* rlhfl i`jhbnv Fiotpkfthob Qkpthnvti n|flkobn hogipmkthio rhtli~t pnbkpd ti rlntlnp tln fiod~ft `nhob hownv-thbktnd ri~jd fiovtht~tn k fphmn ~odnp tln jkrv ig tln pn{~nvtnd FiotpkfthobQkptx/

N|flkobn ig hogipmkthio ho ìtl fhwhj kod fphmhokj tk| mkttnpv,TiP F/;/7(

;78/ Hogipmkthio n|flkobn mkx `n pn{~nvtnd ìtl gip tk| kdmhohvtpkthio

q~pqivnv kod gip tk| qpivnf~thio q~pqivnv/ Tln hotnpokthiokj vtkodkpd hvoit jhmhtnd ti hogipmkthio n|flkobn ho fphmhokj tk| mkttnpv3 ht kjvi hofj~dnvhogipmkthio pn{~nvtnd gip tk| kdmhohvtpkthio q~pqivnv ,kjvi pngnppnd ti kvfhwhj tk| mkttnpv(/

;21/ Kjj ig tln T~pcv kod Fkhfiv Hvjkodv THNKv qpiwhdn gip n|flkobn ig hogipmkthio ho ìtl fhwhj kod fphmhokj tk| mkttnpv/

Qpiwhdn hogipmkthio ho vqnfhghf gipm pn{~nvtnd ,TiP F/;/2(

;2;/ Tlnpn kpn oi pnvtphfthiov ho tln T~pcv kod Fkhfiv Hvjkodv dimnvthfjkrv tlkt ri~jd qpnwnot ht gpim qpiwhdhob hogipmkthio ho k vqnfhghf gipm* vijiob kv tlhv hv fiovhvtnot rhtl htv iro kdmhohvtpkthwn qpkfthfnv/ Tlhv hv pnho-gipfnd ho kjj ig tln T~pcv kod Fkhfiv Hvjkodv THNKv* rlhfl fiotkho qpiwh-vhiov vhmhjkp ti Kpthfjn >,6( ig tln INFD Midnj THNK/ Kpthfjn >,6( i jhbnvFiotpkfthob Qkpthnv ti qpiwhdn* io pn{~nvt* hogipmkthio ho tln gipm ig dhvqivh-thiov ig rhtonvvnv kod k~tlnothfktnd fiqhnv ig iphbhokj pnfipdv ti tln n|tnotkjjirk`jn ~odnp dimnvthf jkr/

Ho gipfn ,TiP F/;/,;( ig tln 0110 Midnj Kbpnnmnot pnkdv Tln fimqntnot k~tliphtx ig tlnpn{~nvtnd Qkptx vlkjj qpiwhdn ~qio pn{~nvt hogipmkthio gip tln q~pqivnv pngnppnd ti ho Kpthfjn ;/ V~fl hogipmkthio vlkjj `n n|flkobnd rhtli~t pnbkpd ti rlntlnp tln fiod~ft `nhob hownvthbktnd ri~jd fiovtht~tn k fphmn ~odnp tln jkrv ig tlnpn{~nvtnd Qkptx hg v~fl fiod~ft iff~ppnd ho tln pn{~nvtnd Qkptx


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>1 FIMQJHKOFN RHTL TLN VTKODKPDV5 N\FLKOBHOB HOGIPMKTHIO

;26/ Kv ig 7 Mkx 01;;* tln T~pcv kod Fkhfiv Hvjkodv lkv vhbond ;7 THNKv/Vnwno ig tlnvn THNKv lkwn `nno `pi~blt hoti gipfn/ Tln T~pcv kod FkhfivHvjkodv lkv hvv~nd Ipdnpv kqqjxhob tln qpiwhvhiov ig tln THN Ipdhokofn tikoitlnp vnwno THNKv* tlnpn`x fimqjnthob kjj tln onfnvvkpx vtnqv io htv qkptti pkthgx tlnm/ 44 Tlnvn vnwno kbpnnmnotv rhjj `n `pi~blt hoti gipfn ho kffipd-kofn rhtl tln pnvqnfthwn notpx hoti gipfn kpthfjnv iofn tln T~pcv kod FkhfivHvjkodv NIH qkptonpv fimqjntn tlnhp hotnpokj qpifnd~pnv/

@n bhwno nggnft tlpi~bl dimnvthf jkr ,TiP F/;/8(

;24/ Gip hogipmkthio n|flkobn ti `n nggnfthwn tln qkpthnv ti ko NIHkppkobnmnot onnd ti nokft jnbhvjkthio onfnvvkpx ti fimqjx rhtl tln tnpmv ig tln kppkobnmnot/ Tln T~pcv kod Fkhfiv Hvjkodv THNKv kpn bhwno tln gipfnig jkr tlpi~bl tln Biwnpoip hvv~hob ko Ipdnp ~odnp tln THN Ipdhokofn/Lirnwnp* kv lhbljhbltnd ho Qkpt @ ig tlhv pnqipt* tln qpiwhvhiov biwnpohob tlnfimqntnot k~tliphtxv qirnpv ti kffnvv hogipmkthio di oit v~gghfhnotjx nok`jntln T~pcv kod Fkhfiv fimqntnot k~tliphtx ti mnnt kjj htv i`jhbkthiov ~odnp tlnTHNKv/

;2>/ Ht hv pnfimmnodnd tlkt tln T~pcv kod Fkhfiv Hvjkodv kmnod htvdimnvthf jnbhvjkthio vi tlkt ht fko i`tkho kod n|flkobn kjj pnjnwkot hogipmk-thio ~odnp htv THNKv/



Tln njnmnot hv oit ho qjkfn/

Gkftipv ~odnpjxhob pnfimmnodkthiov Pnfimmnodkthiov

Tln T~pcv kod Fkhfiv Hvjkodvkppkobnmnotv qpiwhdhob gip hotnpok-thiokj n|flkobn ig hogipmkthio lkwnoit `nno bhwno g~jj nggnft tlpi~bldimnvthf jkr kv tlnpn kpn jhmhtkthiov

io tln k~tliphthnv qirnpv ti i`tkhoonfnvvkpx hogipmkthio gip tln q~pqivnig hotnpokthiokj hogipmkthio n|flkobn/

Tln T~pcv kod Fkhfiv Hvjkodv vli~jdkmnod htv dimnvthf jnbhvjkthio vi tlktht fko bhwn g~jj nggnft ti tln tnpmv ig htvNIH kbpnnmnotv/

44/ Tlnvn vnwno kbpnnmnotv kpn tln kbpnnmnotv rhtl K~vtpkjhk* Dnomkpc* Ghojkod* Ontlnpjkodv* Oiprkx* Vrndno* tln ^ohtnd Chobdim


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FIMQJHKOFN RHTL TLN VTKODKPDV5 N\FLKOBHOB HOGIPMKTHIO >;

F/0/ N|flkobn ig hogipmkthio mnflkohvmv rhtl kjj pnjnwkot qkptonpv

Tln e~phvdhfthiov ontripc ig hogipmkthio n|flkobn mnflkohvmv vli~jd fiwnp kjj pnjnwkot qkptonpv/

;27/ ^jthmktnjx* tln hotnpokthiokj vtkodkpd pn{~hpnv tlkt e~phvdhfthiovn|flkobn hogipmkthio rhtl kjj pnjnwkot qkptonpv* mnkohob tlivn rli kpnhotnpnvtnd ho notnphob hoti ko hogipmkthio n|flkobn kppkobnmnot/ Kbpnnmnotvfkooit `n fiofj~dnd iojx rhtl fi~otnpqkpthnv rhtli~t nfioimhf vhbohghfkofn/Hg ht kqqnkpv tlkt k e~phvdhfthio hv png~vhob ti notnp hoti kbpnnmnotv ip onbithk-thiov rhtl qkptonpv* ho qkpthf~jkp ionv tlkt lkwn k pnkviok`jn n|qnftkthio ig pn{~hphob hogipmkthio gpim tlkt e~phvdhfthio ho ipdnp ti qpiqnpjx kdmhohvtnp kod nogipfn htv tk| jkrv* ht mkx hodhfktn k jkfc ig fimmhtmnot ti hmqjnmnottln vtkodkpdv/

;22/ Tln T~pcv kod Fkhfiv Hvjkodv lkv vhbond THNKv rhtl ;7 e~phvdhfthiov*ig rlhfl ;4 kpn INFD fi~otphnv 4>/ Htv ontripc ig NIH kbpnnmnotv fiwnpv ionig htv cnx tpkdhob qkptonpv* tln ^ohtnd Chobdim* `~t oit tln itlnp cnx tpkdhob

qkptonp* rlhfl hv tln ^ohtnd Vtktnv/ Tln T~pcv kod Fkhfiv Hvjkodv k~tliphthnvlkwn kdwhvnd tlkt tlnx kpn ho onbithkthiov rhtl k o~m`np ig itlnp e~phvdhfthiovti fiofj~dn NIH kbpnnmnotv3 tlnvn hofj~dn htv vhbohghfkot tpkdhob qkptonpv/

;2/ K~vtpkjhk* Fkokdk* Dnomkpc* Ghojkod* Gpkofn* Bnpmkox* Hfnjkod* Hpnjkod* Ontlnpjkodv* Onr Unkjkod* Oiprkx* Qipt~bkj* Vrndno* ohtnd Chobdim


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Tln njnmnot hv ho qjkfn* `~t fnptkho jnbkj kvqnftv ig tln jnbkjhmqjnmnotkthio ig tln njnmnot pn{~hpn hmqpiwnmnot /


Tln T~pcv kod Fkhfiv Hvjkodv lkvk ontripc ig NIH kppkobnmnotvrhtl pnjnwkot qkptonpv `~t tlnx lkwnoit `nno bhwno g~jj nggnft tlpi~bldimnvthf jkr/

Tln T~pcv kod Fkhfiv Hvjkodv vli~jdnov~pn ht bhwnv g~jj nggnft ti tln tnpmv ig htv NIH kppkobnmnotv ho ipdnp ti kjjirgip g~jj n|flkobn ig hogipmkthio ti tlnvtkodkpd rhtl kjj htv pnjnwkot qkptonpv/

Tln T~pcv kod Fkhfiv Hvjkodv vli~jdfiotho~n ti dnwnjiq htv NIH ontripcrhtl kjj pnjnwkot qkptonpv/

F/6/ Fioghdnothkjhtx

Tln e~phvdhfthiov mnflkohvmv gip n|flkobn ig hogipmkthio vli~jd lkwn kdn{~ktnqpiwhvhiov ti nov~pn tln fioghdnothkjhtx ig hogipmkthio pnfnhwnd/

Hogipmkthio pnfnhwnd5 dhvfjiv~pn* ~vn* kod vkgnb~kpdv ,TiP F/6/;(

;28/ Biwnpomnotv ri~jd oit nobkbn ho hogipmkthio n|flkobn rhtli~t tlnkvv~pkofn tlkt tln hogipmkthio qpiwhdnd ri~jd iojx `n ~vnd gip tln q~pqivnv

qnpmhttnd ~odnp tln n|flkobn mnflkohvm kod tlkt htv fioghdnothkjhtx ri~jd `n qpnvnpwnd/ Hogipmkthio n|flkobn hovtp~mnotv m~vt tlnpngipn fiotkho fio-ghdnothkjhtx qpiwhvhiov tlkt vqnjj i~t vqnfhghfkjjx ti rlim tln hogipmkthio fko

`n dhvfjivnd kod tln q~pqivnv gip rlhfl tln hogipmkthio fko `n ~vnd/

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FIMQJHKOFN RHTL TLN VTKODKPDV5 N\FLKOBHOB HOGIPMKTHIO >6

pn{~nvt* ip hv pn{~hpnd ti tkcn kox kfthio* ip v~qqjx kox hogipmk-thio ho pnvqiovn ti ip ho pnjkthio ti kox mkttnpv ti rlhfl k pn{~nvt pnjktnv* vlkjj dhvfjivn tln gkft ig tln pnfnhqt ig v~fl pn{~nvt ip koxitlnp qkpthf~jkpv pn{~hpnd ip hogipmkthio v~qqjhnd ti kox itlnp

qnpvio n|fnqt ho kffipdkofn rhtl tln Kbpnnmnot/

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k pn{~nvt gip NIH/ Ti tln n|tnot* tlnpngipn* tlkt ko kttiponx kftv kv k oimhonnvlkpnlijdnp* k tp~vtnn* k vnttjip* k fimqkox dhpnftip ip ~odnp k qirnp ig kttip-onx ti pnqpnvnot k fimqkox ho htv `~vhonvv kggkhpv* NIH pnv~jthob gpim kodpnjkthob ti kox v~fl kfthwhtx fkooit `n dnfjhond `nfk~vn ig tln kttiponx-fjhnot

qphwhjnbn p~jn/

N|fnqthiov ti pn{~hpnmnot ti qpiwhdn hogipmkthio ,TiP F/4/;(

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FIMQJHKOFN RHTL TLN VTKODKPDV5 N\FLKOBHOB HOGIPMKTHIO >>

F/>/ Thmnjhonvv ig pnvqiovnv ti pn{~nvtv gip hogipmkthio

Tln e~phvdhfthio vli~jd qpiwhdn hogipmkthio ~odnp htv ontripc ig kbpnnmnotvho k thmnjx mkoonp/

Pnvqiovnv rhtlho 81 dkxv ,TiP F/>/;(

;81/ Kjj ig tln T~pcv kod Fkhfiv Hvjkodv THNKv fiotkho qpiwhvhiov vhmhjkp ti Kpthfjn >,7( ig tln INFD Midnj THNK* rlhfl i jhbnv Fiotpkfthob Qkpthnvti giprkpd tln pn{~nvtnd hogipmkthio kv qpimqtjx kv qivvh`jn ti tln kqqjhfkotQkptx/ Ho qkpthf~jkp* Fiotpkfthob Qkpthnv kpn pn{~hpnd ti fioghpm pnfnhqt ig kpn{~nvt ho rphthob ti tln kqqjhfkot Qkptx kod oithgx tln kqqj

peer review report phase 1 turks and caicos islands

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