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The Management Philosophy of Sannova is to makecontributions to people’s health and spiritually richlives.Our company was founded in 1923 to develop andManufacture pharmaceuticals under the name ofSansho Co., Ltd. We changed the corporate nameto Sannova Co., Ltd. in 1999, and have establisheda world-level pharmaceutical factory to constantlysupply good quality medicines to patients.

Since April, 2016, Sannova has joined the Alfresa Group and made greatefforts to ensure stable supply of good quality medicines at affordableprices (competitive and reasonable prices) for patients and customers.Because the use of generic medicines is growing and the number ofcontract manufacturers is increasing, the competition among thepharmaceutical companies has become fiercer than ever before.In such an environment, we are making every effort to win trust frompatients and customers as a Development-Oriented CMO (ContractManufacturing Organization), and we ensure stable product supply, goodquality, competitive cost, speed, and technology so that we can deliverour medical products and services in a timely manner.We always appreciate your continuing understanding and support.

Toru Takekawa, President Director

The Management Philosophy of Sannova isContribution to people’s Health and Spiritually Satisfying Lives

・ We conduct business that can contribute to people’s healthyand comfortable lives.

・ We create a new corporate culture based on our core values :Truth, Trust, and Transparency.

・ We seek after and create highest technology and quality.

・ We place a high value on people in our business becausepeople build the future of the company.

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Management Philosophy

Quasi Drug

Prescription medicines

Non-prescription medicines

Sannova delivers Good Quality Medicines to Patients and Customers

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Sannova produces wide variety of products, such as prescriptionmedicines, non-prescription medicines, and quasi-medicines, as well asfood additives and investigational new drugs based upon the technologyand trust we have built over many years.We provide various formulations, such as tablets (sugar-coated tablets,film-coated tablets, molded tablets, etc.,) capsules, granule, powder,liquid, ointment (cream), etc. We use our experience and will seekfurther improvement in our manufacturing technology hereafter.We use the latest technologies and produce good quality medicines ataffordable price and supply them stably with the production facilities,equipment, environment and systems which are compliant with PIC/SGMP.

● Formulations

● Packages

Film-coated Tablet

Granule

Sugar-coated Tablet

LiquidFine Granule

Capsule

Aluminum-Aluminum Blister Package

Deairing Bulk Package

Double-Formingpackage

Uncoated Tablet

Plastic Bottle with One-Touch Cap

Glass BottleDivided Package

We provide a wide variety of Formulations and Packages

Main Formulation and Package Variety

Blister Package(Press Through Package)

Ointment (Cream)

Tube package

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Location: Ojima Industrial Park, Ota City, Gunma

Site area: 58,000 m2

Ares: Formulation, Filling-Packaging, API,Quality Control and Technology, Warehouse, Energy Center, Wastewater Treatment, Training, Administration, and Cafeteria

Green coverage: 21.3%

Outline of the Factory

PIC/S GMPPharmaceutical Inspection Convention and Pharmaceutical InspectionCo-operation Scheme GMP : Global Standard of GMP

Pharmaceutical Factory for Ensuring Safety and Security

Make Contributions to Patients Comply with the PIC/S GMP Ensure Stable Supply of Good Quality Products Be compatible with Small-Volume Production Ensure Safety and Conserve the Environment

Concepts of the Factory

The production facilities, equipment,environment, and systems of theSannova main factory are compliantwith the PIC/S GMP, and we areproducing good quality medicines inthis factory.Each package of the materials andproducts is controlled with Bar-CodeManagement Systems.

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(2) Mixing and Kneading: Agitator/Mixer

(3) Granulation: Fluidized-Bed Granulator

(1) Material Weighing System and Local Air ExhausterVentilation

(6) Screening: Screening Machine(5) Coating: Pan-Coating Machine(4) Tableting: Tableting Machine

(8) Packaging: Pillow-Type Packaging Machine

(7) Filling: BlisterPackaging Machine

(9) Packaging: Robot Caser

Factory Equipment

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Sannova Co., Ltd. develops our business activities based upon thephilosophy of contributing to the human health and spiritually rich life.We value the voices of the patients and consumers and offer theproducts and services that they can use safely.Therefore, we establish the following policies.

• We shall ensure stable supply of good quality products and services• From the global point of view, we shall comply with applicable laws

and regulations, respect the ethics, always seek improvements, andoperate the quality control system

• We shall always think from the viewpoint of patients and customers,and perform our duties in a humble and speedy manner

• Each section shall understand its responsibilities and assure productquality.

• All employees shall understand the importance of quality, and eachperson shall ensure that every product or service meets its qualitytarget

Win Trust with High-Level Quality Assurance

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Quality Policies

Quality analysis performed by trained analysts

Stability test roomAnalysis area for final products

Quality, created by PeopleEach employee of Sannova focuses on the quality ofour products and services. Therefore, our productsare safe to use for every patient.We have approached quality control issues on acompany-wide basis and established a qualityassurance system so that we can provide reliableproducts for all patients and customers.

Monument of our Philosophy of Manufacturing

Quality Control in accordance with GMP and GQP

In accordance with national standards, such as GMPand GQP, we strictly control quality - fromacceptance of materials to shipment of the products- in order to maintain the quality of our products.We have established quality control and productionsupport systems for all processes from the materialto final products, which control water, productionenvironment and cleaning.We also have installed a system that maintainsproduction procedures in optimal conditions.

GMP： Good Manufacturing PracticeGQP： Good Quality Practice

Safety Control and Post-Marketing StudyIn compliance with GVP and GPSP, we ensure thesafety of our medicines for every patient.

GVP： Good Vigilance PracticeGPSP：Good Post-Marketing Study Practice

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Pharmaceutical DevelopmentWhile taking the cost and quality into account, weare conducting a wide range of studies, such asformulation of new products, study of productionmethods, quality improvement in existing products,streamlining of the production processes, etc.

Packaging DesignFrom the viewpoint of patients and medicalprofessionals who are actually using our products,we are conducting studies of easy-to-use packagedesigns and easy-to-follow labels in order to supplythem at low cost.

Clinical PracticeFor development of new medicines, we areconducting clinical trials in accordance with GCP, andstudying the effectiveness and safety of the productsfor people.

GCP: Good Clinical Practice

Analysis and EvaluationWe have established various analytical methods thatenable to evaluate medicines quickly and accurately.Analysis and evaluation of newly developingproducts are the part of our business coveringfrom development to obtainment of manufacturingand sales approval.

High-speed Agitation / Mixing Device

Stereo Microscope System

V-type Blender

For Development of High-Value Products

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Kaizen Presentation Seminar for next generation human resources (team-building activity)

People Build the Future of our Company

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People are the source of everything in our company, who can build the future of ourcompany.Each employee at Sannova is required to be independent, so that they can think, act,and make changes independently. While upholding the traditions and corporateculture established over more than 90 years, we are always reviewing our workingstyle and systems in order to adapt them to the fast-changing business environment.In order to respect each employee’s personality and reward their efforts, we haveintroduced a fair personnel evaluation system. It is important to be motivated forchallenges and find satisfaction in work.We will keep developing good human resources who are independent and motivatedfor challenges.Sannova offers various educational opportunities for our employees: Group seminars, on-the-job training, etc. in workplaces Seminars for employees at specific Job grades, which facilitates cross-departmental

communication and competition among the participants Kaizen (Improvement) presentations where results of Kaizen Activities are reported Correspondence education courses freely selected by employees Lecture-style seminars provided by teachers from inside and outside of the company

Sannova supplies safe and reliable medicines and services.Our mission is to make contributions to each patient and customer.

Ota City Science Academy (educational program hosted by Ota City)

Relay For Life Japan Gunma (24-hour walk rally held to raise funds for conquering cancer)

Active Contribution to our Society as a Good Corporate Citizen

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As a Good Corporate Citizen, Sannova makes Active Contributions to our Society

With our EmployeesSannova is focusing on creating a safe and comfortablework environment for our employees so that they canuse all of their abilities in their work. Besides, eachemployee is aware of the importance of “protectingthemselves from accidents” and working on variousmeasures to prevent accidents in the workplace.Sannova also focuses on human resource developmentwhile respecting everyone’s personality.We support our employees in having a productiveprivate life by setting no-overtime days on a regularbasis and encouraging them to take paid holidays.

Actions for the EnvironmentSannova is taking high-level actions for environmentalconservation in accordance with the internationalstandard of environmental management, ISO 14001(certified in 2001.)We are using a central monitoring system to increaseefficiency in our energy use and taking measures forenergy conservation and recycling of resources.

Social Contribution ActivitiesIn order to create a good relationship with the localcommunity, we are performing and participating invarious activities, such as cleaning around the factoryand an educational program hosted by Ota City, wherewe explained production process of medicines toelementary school students.In addition, we communicate with many patients invarious events in order to review our mission.

1923 Started business as a pharmaceuticals developer and manufacturer under the name ofSansho Co., Ltd.

1933 The business expanded due to the success of the liver oil tablet, “Haliva.”

1965 Accepted investment from Eisai Co., Ltd., and started production of medical products forEisai.

1986 Eisai Co., Ltd. released the medicine for iron-deficiency, anemia, developed by Sansho

1989 Acquired an authorization of contract manufacturing from Eisai Co., Ltd.

1997 Started production of barrier-free medicines, marketed by Elmed Eisai Co., Ltd.Acquired a manufacturing authorization of liquid-, ointment-, and cream-form medicinesfrom Eisai Co., Ltd.

1998 Relocated the headquarters to Serada-Cho, Ota City, Gunma(previously known as Ojima-machi, Nitta-gun)

1999 Completed relocation of the whole company to Serada-Cho, Ota City, Gunma

Changed the corporate name to Sannova Co., Ltd.

2001 Obtained the ISO 14001 certification.Obtained the OHSAS 18001 certification (withdrawn in 2015).

2002 Obtained the ISO 9001 certification (withdrawn in 2011).

2004 Added the north building and new drainage treatment facilities.

2006 Replaced the boilers with gas-fueled boilers (for environment protection).

2011 Introduced an in-house power generator (545 kW).

2013 Celebrated the 90th Anniversary of the foundation

2016 Joined the group of Alfresa Holdings Corporation.

Year of Establishment : 1923

Capital : 300.2 million yenAddress : 3038-2 Serada-cho, Ota City,

Gunma 370-0426, JapanTEL. 0276-52-3611

Scope of Business : Research and development, manufacturing, and sales of medicines and healthcare products

Annual Sales : Approx. 8.8 billion yen (2019)Employees : 391 (as of April 1, 2020)Account closing date : March 31Corporate Shareholder : Alfresa Holdings CorporationMajor Business Clients : Eisai Co., Ltd., Elmed Co., Ltd., Takata Pharmaceutical Co., Ltd.,

Mitsubishi-Chemical Foods Corporation, Kobayashi Kako, Co., Ltd.Main Financing Bank: Saitama Resona Bank, Limited. MUFG Bank, Ltd.

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Outline

History

Ota City, Gunma

Sannova is located in the Ojima Industrial Park in Ota City, Gunma Prefecture. The location is accessible from the Kan-Etsu Expressway and Kita-Kanto Expressway and convenient for transportation of products.

Access

From Tobu Isesaki Line Serada Station: 8 minutes by footFrom JR Takasaki Line Fukaya Station: 25 minutes by carFrom Kan-Etsu Expressway Hanazono IC: 40 minutes by carFrom Kan-Etsu Expressway Honjo-Kodama IC: 30 minutes by carFrom Kita-Kanto Expressway Isesaki IC: 20 minutes by carFrom Kita-Kanto Expressway Ota-Yabuzuka IC: 20 minutes by car

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