peptides international 2015 product catalog - new version

Leading by Excellence Since 1983Certified to ISO 9001:2008

Introducing our latest section, which includes over 4500 new products!NEW!

01CustomPeptide

Synthesis

02CustomOrganic

Synthesis

SpecialtyProducts &

Technologies

01CustomPeptide

Synthesis

02CustomOrganic

Synthesis

SpecialtyProducts &

Technologies

07CosmeticPeptidesTools forPeptide

Synthesis

01CustomPeptide

Synthesis

01CustomPeptide

Synthesis

02CustomOrganic

Synthesis

01CustomPeptide

Synthesis

02CustomOrganic

Synthesis

SpecialtyProducts &

Technologies

07CosmeticPeptides

Product Catalog - 11.1

Edition

Dear Customers:

Throughout its many years of service, the team at Peptides International has maintained a commitment to offer a continuous stream of innovative products to facilitate ever-expanding areas of peptide research. In our current catalog you will find hundreds of new products re-flecting the increased expertise of our staff. These new offerings range from useful tools for making peptides (e.g. orthogonally protected amino acids and derivatives for Click chemistry) to a plethora of biologically active peptides such as Mambalgin-1 and activated KLH (Keyhole Limpet Hemocynanin) for peptide antigen conjugation. Since publication of a catalog cap-tures just one point in time, we invite you to look for our latest product additions at PEPNET.COM under the New Products tab.Investment in additional state-of-the-art automated synthesis equipment now allows us to produce milligram to kilogram quantities of peptides even more efficiently. All of our produc-tion and distribution operations have also been certified to the ISO 9001:2008 International Quality System Standard, reflecting commitment to the quality of our products and the satis-faction of our customers. New additions to our peptide chemistry team include experts that can handle all of your discovery and development needs, whether your project involves com-plex organic chemistry or standard solid-phase techniques. Scale-up and smooth technol-ogy transfer into drug API products under full-cGMP is also available without any disruption from our cGMP partner, Peptisyntha.

We thank you for your interest in our products and services and invite you to search for your peptide needs in our exciting new catalog. Should you require larger quantities than are listed, additional savings may be available by requesting a bulk quotation. We are confident that you will find all of our products competitively priced while giving you extraordinary value and quality that will lead to success in your research.

Sincerely,

Peptides International

Michael W. Pennington, Ph.D.President and Chief Executive Officer

Jackie B. SpatolaChair, Board of Directors

Since 1983, Peptides International, Inc. has been an established provider of catalog products and custom chemistry services, supporting peptide research and development around world. Built on a passion for excellence, the company has become recognized as a trusted source of high purity, quality products, and cost effective custom chemistry services.The companys Louisville facility consists of multiple self-contained laboratory suites, a kilo-scale pilot plant, fully equipped quality control laboratories, and supporting quality assurance and business departments. Peptides International is now Certified to ISO 9001:2008, reflecting its commitment to the quality of its products and satisfaction of its customers.Peptides International specializes in biologically active peptides and peptide-related products, glyco-conjugates, defined-length PEGylations, enzyme substrates and inhibitors, amino acid derivatives, combinatorial peptide libraries, and a variety of resins and reagents. Purification of custom-produced products is carried out by conventional techniques such as solvent-solvent extractions, crystallizations, and by preparative chromatographic instrumentations column sizes to 110mm diameter suitable for ion-exchange, flash-chromatography and reverse phase HPLC methodologies. Whether it is milligram or kilogram scale-up quantities, Peptides International has the expertise and technology to support your drug discovery, development, and manufacturing objectives.

Peptides International, Inc.Physical Address 11621 Electron Drive Louisville, Kentucky 40299

Mailing Address P. O. Box 99703 Louisville, Kentucky 40269-0703

Phone 1-502-266-8787 (Local and International Callers) 1-800-777-4779 (Toll-free USA and Canada only)

Fax 502-267-1329

Email [email protected]

Website

Social Media

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Subsections in Bold Introduction

Peptide Institute ...........................................................................................................................viiDistributors ..................................................................................................................................viiicGMP............................................................................................................................................ ixQuality ........................................................................................................................................... xProduct Information ..................................................................................................................... xiProduct Packaging .......................................................................................................................xiiCommunication ...........................................................................................................................xixPurchasing .................................................................................................................................. xxUsing the Catalog ......................................................................................................................xxii Terms and Conditions ...............................................................................................................xxiii Custom Peptide Synthesis ..................................................................................................... xxviii Technology Platforms ............................................................................................................... xxx

Biologically Active Peptides ......................................................................................1Adrenomedullins and Related Peptides.......................................................................................2 Amylins ..........................................................................................................................................9 Amyloid -Protein Related Peptides ............................................................................................9 Angiotensin and Related Peptides .............................................................................................13 Arg-Gly-Asp "RGD" Peptides .....................................................................................................20 Bradykinin and Related Peptides ...............................................................................................27 Defensin Peptides .......................................................................................................................39Endothelins..................................................................................................................................47Enkephalins .................................................................................................................................51Experimental Autoimmune Encephalomyelitis Products ...........................................................54Galanins and Related Peptides..................................................................................................57 Ghrelin and Related Peptides ....................................................................................................59 Growth Hormone Releasing Factor (GRF, GH-RH) and Growth Hormone Related Peptides ....................................................................................64Guanylins and Uroguanylins .....................................................................................................65Hepcidin ......................................................................................................................................67 Kisspeptins/Metasins ..................................................................................................................72 Melanin-Concentrating Hormone and Related Peptides .........................................................77Neuroendocrine Regulatory Peptides ........................................................................................82Parathyroid Hormone (PTH) and Related Peptides ..................................................................93 Protease-Activated Receptor (PAR) Peptides .........................................................................101 RF Amide Related Peptides .....................................................................................................107 Stresscopins / Urocortin and Related Peptides ....................................................................... 110 Substance P and Related Peptides ......................................................................................... 111Toxins ........................................................................................................................................ 114Urotensin II and Related Peptides ...........................................................................................133Vasoactive Intestinal Peptide (VIP) ..........................................................................................134 Vasopressin, Vasotocin, and Related Peptides .......................................................................135

Table of Contents

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Enzyme Inhibitors and SubstratesAssay Methods Substrates .....................................................................................................137

Enzyme Inhibitors .......................................................................................................................143Angiotensin I Converting Enzyme Inhibitors ............................................................................145 Caspase Inhibitors ....................................................................................................................147 Cathepsin and Thiol Protease Inhibitors ..................................................................................151 Chymotrypsin and Chymotrypsin-like Inhibitors ......................................................................154 Collagenase / MMP / Stromelysin Inhibitors ............................................................................155 Elastase Inhibitors .....................................................................................................................157Ubiquitin Proteasome System Inhibitors ..................................................................................161 Examples of Proteolytic Enzymes and Their Inhibitors ...........................................................163

Enzyme Substrates & Related Compounds ............................................................................164ADAM-17 Substrates .....................................................................................................................164 Aminopeptidases Substrates ........................................................................................................165 Calpain Substrates ........................................................................................................................169 Caspase Substrates ......................................................................................................................170 Cathepsin and Thiol Protease Substrates ....................................................................................172 Chymotrypsin and Chymotrypsin-like Protease Substrates ........................................................174 Coagulation Factor Substrates .....................................................................................................175 Collagenase / MMP / Stromelysin Substrates ..............................................................................178 Elastase Substrates.......................................................................................................................181 Furin and Carboxyl Side of Paired Basic Residue Cleaving Enzyme Substrates ......................183 Ubiquitin Proteasome System Substrates ....................................................................................196FRETs Peptides Library ................................................................................................................199Polypeptides ..................................................................................................................................205 Oligopeptides .................................................................................................................................205

Dipeptides ...............................................................................................................................205 Tripeptides ..............................................................................................................................206 Tetrapeptides ..........................................................................................................................207

Specialty Products and Services Click Chemistry ...........................................................................................................................209Specialty Biologically Active Peptides ..................................................................................... 211

Derivatizable Cell Penetrating Peptides (CCPs) ..................................................................... 211Other Specialty Peptides .......................................................................................................... 211

Carbohydrates .............................................................................................................................212Glycosidase Inhibitors ...............................................................................................................212 Endotoxins (Synthetic) ..............................................................................................................216 Antiproliferative Factor ..............................................................................................................217Maleimide activated-KLH ..........................................................................................................219 Specialty Tools for Peptide Synthesis .................................................................................221mini-PEG ...............................................................................................................................221 CLEAR-OXTM ............................................................................................................................222CLEARTM ...................................................................................................................................226

Peptide Antisera ..........................................................................................................................228Antisera of Amyloid -Protein Related Peptides......................................................................229Endothelin Antisera ...................................................................................................................233

Table of Contents (cont.)

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Tools for Peptide SynthesisAmino Acids .................................................................................................................................240

Click Chemistry Amino Acids ....................................................................................................240 l-Amino Acids ............................................................................................................................245 d-Amino Acids ...........................................................................................................................244 Amino Acid Esters .....................................................................................................................245 Side Chain Derivatives of Amino Acids ....................................................................................246 Boc-Protected l-Amino Acids ...................................................................................................247Boc-Protected d-Amino Acids...................................................................................................250 Unusual Boc-Amino Acids ........................................................................................................251 Boc-N-Methyl Amino Acids .......................................................................................................258Boc-Amino Acid Esters .............................................................................................................258 Fmoc-Protected l-Amino Acids ................................................................................................259 Fmoc-Protected d-Amino Acids ................................................................................................263 Unusual Fmoc-Amino Acids .....................................................................................................264 Fmoc-N-Methyl Amino Acids ....................................................................................................270 Z-Protected l-Amino Acids .......................................................................................................271 Unusual Amino Acids ................................................................................................................273

Resins ...........................................................................................................................................274Unsubstituted Resins for Solid Phase Synthesis ....................................................................274 Chlorotrityl Resins .....................................................................................................................276 Boc-Amino Acid-Pam Resins ...................................................................................................279 Fmoc-Amino Acid-Wang Resins ..............................................................................................281 Fmoc-Amino Acid-Rink-Amide MBHA Resins .........................................................................283 TentaGel Resins ........................................................................................................................285

Reagents .......................................................................................................................................291Condensation Reagents, Additives, Linkers, and Other Reagents for Peptide Synthesis ....291 Boc-Amino Acid-Pam Linker Reagents ...................................................................................293 Protein Ligation Synthesis Reagents .......................................................................................294 PyClocK ...................................................................................................................................295dPEG .......................................................................................................................................296

Laboratory Equipment ................................................................................................................ 311Tubing and Connectors ............................................................................................................ 311 Specialty Glassware ................................................................................................................. 311 Replacement Screw Caps and Septa ......................................................................................313HF Apparatus and Parts ...........................................................................................................313

Recombinant ProteinsCytokines and Growth Factors .................................................................................................314

Clusterins ..................................................................................................................................320Defensins ..................................................................................................................................323GH (Growth Hormone) ............................................................................................................. 368IFI30 (-Interferon-Inducible Lysosomal Thiol Reductase) ..................................................... 379Interlukins ..........................................................................................................................388-429IL1F7 (Human Interleukin Family 1, Member 7)...................................................................... 429IL1F10 (Human Interleukin Family 1, Member 10) ................................................................. 430Insulin ........................................................................................................................................ 431


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Recombinant Proteins (continued)Leptin ......................................................................................................................................... 433Midkines .................................................................................................................................... 445 Pleiotrophin ............................................................................................................................... 462Prolactin..................................................................................................................................... 465RBP1 (Recombinant Human Retinol Binding Protein-1) ........................................................ 474SCF (Stem Cell Factor) ............................................................................................................ 477 TNF (Tumor Necrosis Factor) .................................................................................................. 489

Chemokines ................................................................................................................................. 510Hormones ..................................................................................................................................... 556Enzymes ....................................................................................................................................... 562Protein Kinases ........................................................................................................................... 614Recombinant and Natural Proteins .......................................................................................... 629Heat Shock Proteins ................................................................................................................... 753Allergy Proteins ........................................................................................................................... 758Maleria Proteins ........................................................................................................................... 758Mumps Protein ............................................................................................................................. 758Shiga Like Pprotein ..................................................................................................................... 758Viral Antigens SARS Proteins ................................................................................................... 758Viral Antigens SARS Proteins Borrelia Protein ...................................................................... 759Viral Antigens - Chagas Protein ................................................................................................ 760Viral Antigens - Herpes Simplex Virus ..................................................................................... 760Viral Antigens - Chlamydia Trachomatis ................................................................................. 761Viral Antigens - Hepatitis C Virus .............................................................................................. 762Viral Antigens - Hepatitis A Virus .............................................................................................. 767Viral Antigens - Hepatitis B Virus .............................................................................................. 768Viral Antigens - Hantaan Virus .................................................................................................. 768 Viral Antigens -Feline Leukemia Virus ..................................................................................... 768Viral Antigens - Hepatitis D Virus .............................................................................................. 768Viral Antigens - Hepatitis E Virus .............................................................................................. 768Viral Antigens - Hepatitis B Surface Antigens ........................................................................ 769Viral Antigens - Cytomegalo Virus ............................................................................................ 770Viral Antigens - Varizella Zoster Virus ...................................................................................... 771Viral Antigens - Toxoplasma Gondii Proteins ......................................................................... 771Viral Antigens - Treponema Pallidum Proteins ....................................................................... 771Viral Antigens - Human Immunodeficiency Virus................................................................... 772Viral Antigens - Human T-Lymphotrophic Virus ..................................................................... 775Viral Antigens - Human Papillomavirus Virus ......................................................................... 776Viral Antigens - Epstein-Barr Virus ........................................................................................... 776Viral Antigens - Encephalitis Virus ........................................................................................... 777Viral Antigens - Measles Virus ................................................................................................. 778Viral Antigens - Rubella Virus .................................................................................................... 778Viral Antigens - Chikungunya Virus ......................................................................................... 778Viral Antigens - Parvovirus ........................................................................................................ 778Viral Antigens - Influenza Virus ................................................................................................ 778Viral Antigens - West-Nile Virus ................................................................................................ 781Viral Antigens - Dengue Virus ................................................................................................... 781


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Table of Contents (cont.)Recombinant Proteins (continued)Anti - Human Cytokines ............................................................................................................. 784Monoclonal Antibodies, Anti-Human Chemokines ................................................................ 789Monoclonal Antibodies, Anti-Human Lymphocytes ............................................................... 790Monoclonal Antibodies, Anti-Mouse Cytokines ...................................................................... 792Monoclonal Antibodies, Anti-Mouse Lymphocytes ............................................................... 793Monoclonal Antibodies, Anti-Viral ............................................................................................ 794Polyclonal Antibodies, Anti-Human .......................................................................................... 795Monoclonal Antibodies, Anti-Human Heat Shock Proteins .................................................. 797Monoclonal Antibodies, Anti-Human Enzymes ...................................................................... 797Monoclonal / Polyclonal Antibodies, Miscellaneous Antibodies ......................................... 804

From its very inception, Peptides International has been proud to distribute the superb products manufactured by the Peptide Institute of Osaka, Japan. The biologically active peptides synthesized by the Peptide Institute are well known for their excellent quality. In addition to its historic link with the Peptide Institute, Peptides International works with other key suppliers around the world to supplement its own manufactured products to provide a complete portfolio of peptides and related products, as well as tools for peptide synthesis and research.

The Peptide Institute is a leading supplier of biologically active peptides, enzyme substrates and inhibitors, and peptide antisera. Customers in Japan may wish to contact this company directly.Peptide Institute, Inc.4-1-2 Ina Minoh-Shi Osaka 562 JapanPhone (0727) 29-4121Fax (0727) 29-4124 http://www.peptide.co.jp

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In Japan:

http://www.peptide.co.jp Osaka, Japan

Email: [email protected]://www.peptide.co.jp

In Switzerland:

Lucerne, SwitzerlandEmail: [email protected]://www.lubio.ch/

In Benelux:

Huissen, The Netherlands

Email: [email protected]://www.bio-connect.nl/

In Europe, Latin America, Australia, and New Zealand:

San Diego, CA USA

Email: [email protected]://www.axxora.com/index.php

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Distributors

Expertise & Reliability for YOUR cGMP Peptides

Peptides International and Peptisyntha have partnered to create a seamless stream of technology and expertise, allowing you to focus on the project, not project management.

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cGMP Partner

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Quality PolicyIt is Peptides International's goal is to achieve complete customer satisfaction by addressing customer needs and delivering what we promise. The company is committed to the Quality Management Sysyem and through review of quality objectives and metrics, is working towards its improvement and effectiveness.

Specifications and Purity AssaysEach product is accompanied by a detailed lot-specific analytical data sheet contain-ing all specifications. In addition to specification data, additional test results can be made available upon customer request. Product integrity is assured using techniques that include thin layer chromatography, high performance liquid chromatography, opti-cal rotation, nuclear magnetic resonance, IR spectroscopy, and mass spectrometry.

Peptide InstituteProducts from the Peptide Institute of Osaka, Japan are manufactured under strict quality control standards and are accompanied by analytical data sheets directly from the Institute. Peptide International products are designated by a -PI suffix to distinguish them from those produced by the Peptide Institute.

Now Certified to ISO 9001:2008

Quality

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Product Information

Net Peptide WeightSome products from the Peptide Institute are distributed in premeasured vials. These are indicated by the suffix -s, or -v in their catalog number. The net peptide weight is precisely determined by amino acid analysis after acid hydrolysis, HPLC, and/or UV absorption, and the value is indicated clearly on the vial label. The indicated weight is only for the net peptide molecule, and the weights of any constituents (water or acetic acid) are excluded from the quantity. The amount of usable peptide meets and may exceed its advertised quantity.

Stability and StorageComplex peptides and antisera should generally be kept dry and frozen to prevent unnecessary deterioration, although they are stable at ambient temperature for sev-eral days. Almost all biologically active peptides are readily soluble in water or any suitable buffer solution. Stability of peptides in solution is relatively low even below -20 C. Therefore a peptide solution, once prepared, should be used as soon as possible. If the solution must be stored overnight, it should be kept in a freezer at temperatures lower than -20 C. When prolonged storage has occured, homogene-ity of the peptide in the solution should be reconfirmed prior to use. Please refer to the following table and to our website for additional information regarding stability and storage conditions.

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Product Information

Product Storage ConditionsProduct Series Number Storage ConditionL- & D-Amino Acids 2700 & 2800 RTBoc-Amino Acids 2000 & 5000 4 CFmoc-Amino Acids 1700, 1800, & 5000 4 CUnusual Amino Acids 5000 4 CReagents 1000 Varies:

RT, 4 C,

or -20 C

Unsubstituted Resins 1000 & 9000 RTSubstituted Resins 1000, 10000, 1100, 11000,

1200, 12000, 1300, 1400, & 9000

4 C

All CLEAR Resins 1200, 12000 4 CPeptides 3000 & 4000 -20 CInhibitors 3000 & 4000 -20 CSubstrates 3000 -20 CAntisera 8000, 80000, & 14000 -20 CCarbohydrates 24000 -20 C

RT = Room Temperature4 4 C = Refrigerator -20 C = Freezer

All products (except RT) are stored in freezers for inventory purposes.

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All of the products listed in this catalog are rigorously tested and the purity of the products is guaranteed according to the following criteria:

1000 SeriesThese reagent grade chemicals are of a quality confirmed by our chemists in Japan and the USA to be acceptable for peptide synthesis.

1100, 1200, 1300,1400, 10000, 11000 and 12000 SeriesThese substituted resins are manufactured in our Louisville, Kentucky facility. The parameters, described on the analytical data sheet included with each resin, are substitution, percent racemization (where appropriate), bead size, and percent cross-linking.

1700 SeriesFmoc-Amino Acids of the 1700 Series: No free amino acid is detectable by TLC when 100 micrograms is applied to the plate. Purity determined by HPLC analysis is higher than 98%.

2000 SeriesAmino acids of the 2000 Series: The homogeneity of the amino acids is moni-tored by thin layer chromatography (TLC) and is guaranteed to yield a single spot when 50 micrograms is applied to the plate. The optical purity of amino acids is higher than 99.9% except in the case of serine, which is frequently con-taminated by more than 1% enantiomeric serine; data are available on request. Optical purity is determined by Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) using chiral derivatizing reagents.

Product Information

Product Information

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Amino Acid Esters and Side Chain Derivatives of the 2000 Series: The following letters are used to designate the different grades:AA: A single spot is always detectable by two different TLC systems when

200 micrograms is applied to the plate. Homogeneity higher than 99% as determined by paper electrophoresis is guaranteed.

A: A trace of impurity might be detectable by TLC, but the maximum range is less than 2%.

B: Contamination of less than 3% might be detectable.

Boc- and Z-Amino Acids of the 2000 Series:The optical purity of the component amino acids is always higher than 99.9%, and contamination by the sec-butyl group is guaranteed to be less than 0.05%. The following letters are used to designate the different grades:AA: A single spot is detectable by TLC when 200 micrograms is applied to

the plate. The amount of contamination detectable by HPLC, if any, is less than 0.5%.

A: A trace of impurity might be detectable by TLC, but the maximum range determined by HPLC is less than 1%.

B: Contamination of less than 2% might be detectable by HPLC.AA-A: This compound is synthesized as material of grade AA, but may gradu-

ally decompose to grade A within one year, even under cold storage conditions.

A-B: This compound is synthesized as material of grade A, but may gradu-ally decompose to grade B within one year, even under cold storage conditions.

Product Information

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3000 SeriesAmino Acids and Peptide Derivatives of the 3000 Series: The following letters are used to designate the different grades:AA: A single spot is detectable by TLC when 100 micrograms is applied to

the plate. The amount of contamination detectable by HPLC is less than 1%.

A: A trace of impurity might be detectable by TLC when 100 micrograms is applied to the plate. The amount of contamination detectable by HPLC is less than 2%.

B: Contamination of less than 4% might be detectable by HPLC.A-B: This compound is synthesized as material of grade A, but may gradu-

ally decompose to grade B within one year, even under cold storage conditions.

4000 SeriesBiologically Active Peptides of the 4000 Series: All of these peptides are chemically synthesized using carefully selected amino acid derivatives from our products, and strictly purified to come up to our quality standards. Impurities detectable by ordinary gradient HPLC systems are less than 1% and a single TLC spot upon application of 50 micrograms is detected in almost all of our peptides, except Met-containing peptides. Some additional minor peaks on HPLC or minor spots on TLC are detectable with Met-containing peptides since they may be easily oxidized to Met-sulfoxide even during analysis. The peptides which are followed by the words Purity Information and letter symbols, such as Purity Information: QP in this catalog, can be explained as follows:

Product Information

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QP: These compounds have some inherent instability. During storage, even under freezer conditions, a trace of impurity may become visible by TLC analysis. The amount of impurity determined by HPLC is less than 1%.

QE: These compounds have some inherent instability. Their purity is guar-anteed to be higher than 97% by HPLC.

QX: The purity of these compounds is guaranteed to be higher than 97% by HPLC.

QZ: The purity of these compounds is guaranteed to be higher than 95% by HPLC.

5000, 6000, and 53000 Series These unusual amino acids, amino acid derivatives, and other offerings rep-resent an expansion of quality products from Peptides International and are synthesized under appropriately high purity criteria.

14000 Series Peptide Antisera are sold in vials as amorphous powders which are obtained after lyophilization from 0.001 M Phosphate Buffer (pH 7.0). The specificity and sensitivity are determined by the enzyme immunoassay technique specified; the data for each vial are given on an attached sheet.

Bacterial Enzyme Inhibitors The microbial enzyme inhibitors (Microbial Products) listed in this catalog are isolated from cultured media of microorganisms. Many of these compounds are inherently unstable and thus difficult to categorize using our normal standards of purity. The homogeneity of these compounds cannot be guaranteed except for their specific inhibitory activities. Additional data for these series of compounds are available upon request.

Product Packaging

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The biologically active peptides listed in this catalog are sold primarily as amorphous powders which have been lyophilized from aqueous or dilute acetic acid solutions. They are available in two package forms: screw-capped bottles (indicated as Bulk) and injection vials (indicated with a -v or s suffix at the end of each catalog code number).

Screw-capped BottlesThe amorphous powder of each peptide is thoroughly dried over desiccant in vacuo and then weighed in a bottle. The weight indicated on the label represents the gross weight of the amorphous powder, which includes the peptide as well as the accompanying water and acetic acid, if any. The amount of water and acetic acid in each amorphous powder is precisely determined by elemental analysis, Karl Fischer titration or gas chromatography. In some cases, peptides contain hydrochloride or ammonia instead of acetic acid. The observed values of such accompanying constituents are given in the structural formula of the respective peptide described in this catalog. For example, code PBK-4002 Bradykinin is described as follows:

PBK-4002 Bradykinin Bulk 100 mgArg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg 2AcOH 3H2O(M.W. 1060.2 120.10 54.05)

The total molecular weight of this amorphous powder is calculated to be 1234.4, which consists of 1060.2 for the net bradykinin molecule, 120.10 for two mol-ecules of acetic acid and 54.05 for three molecules of water. This means that 100 mg of this powder contains a net weight of 85.9 mg of bradykinin molecules. Amounts of the accompanying water and acetic acid vary with the lot; the exact value in the purchased peptide is available on request.

Product Packaging

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VialsPeptides with constant weights are lyophilized and sealed under nitrogen in indi-vidual vials. Net peptide weights are precisely determined by amino acid analy-sis after acid hydrolysis, HPLC analysis and/or UV absorption measurement, and is clearly indicated on the label of each vial. The indicated weight is only the net peptide molecule and does not include the weight of any additional con-stituents (water, acetic acid, etc.). For example, code PBK-4002-v Bradykinin is described as follows:

PBK-4002-v Bradykinin Vial 0.5 mgArg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg (M.W. 1060.2)

This indicates that each vial contains ca. 0.5 mg of Bradykinin and the exact weight is indicated on the label (for example, 0.53 mg) and the analytical data sheet (for example, 0.53 mg, 0.50 micromol). The weight is precisely determined by quality control, insuring the quantity in each vial even if the content seems to be quite small. A peptide solution of a known concentration can be easily prepared by injecting a given volume of a suitable solvent into the vial using a calibrated syringe and dissolving the contents thoroughly. The peptide content in each vial is relatively small and accurately measured, and the peptide should not be taken out of the vial to prepare a solution with a guaranteed concentration.

Communication

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PEPNET NewsletterPeptide chemistry is constantly changing. The PEPNET newsletter will keep you abreast of many of the exciting new developments arising in the expanded field of peptide chemistry. PEPNET has been published regularly since 1987.

Our web site offers online ordering, new products, and other use-ful information. There are also scientific references, and links to industry organizations.

Social Media Just as peptide chemistry is ever-changing, Peptides International knows the way it conveys these changes will also vary over time. Look for us on Facebook, Google+, LinkedIn, Twitter, and other new outlets as they appear. If you wish to receive your own copy of this catalog or to be entered onto the subscription list for the newsletter, please place a request by contacting the company via telephone, fax, or email ([email protected]).

Custom services to stimulate inhibitor innovations

As a complement to these catalog offerings, Peptides

International also provides custom synthesis services to meet

structural requirements of specific enzyme or disease targets.

Peptides International has a wealth of chemical expertise and

know-how especially applicable to the design and synthesis

of complex enzyme inhibitors and substrates. These include

cyclic compounds (BQ-123), complex mimetics (BQ-788),

peptide aldehydes (Ac-LLN), hydroxamic acid derivatives

(TAPIs), alkylating moieties and others.

P.O. Box 24658Louisville, KY 40224 USA Phone: 502-266-8787Fax: 502-267-1329

A Newsletter from Peptides International

Volume 23, No. 1, 2010

Peptides International, Inc.

1-800-777-4779 E-mail: [email protected]

Enzymes Gone Wild! Inhibitors to the Rescue!

Enzyme inhibitors continue to generate strong research interest...

Product Quality and Value Strict Confidentiality Proactive Project Management Friendly Service

Enzyme inhibitors and related products

Peptides International has long had a strong product focus

in the area of enzyme inhibitors that includes both syn-

thetic and microbial-derived materials. These include, for

example, popular matrix metalloprotease inhibitors (TAPI-0,

TAPI-1, TAPI-2), ubenimex, and actinonin. In addition, we

also offer other key products, such as chymostatin, elastati-

nal, leupeptin and epoxomicin, through our long-standing

distribution relationship with the Peptide Institute of Osaka.

These are available in multiple vials or in bulk quantities that

offer considerable savings.

Enzymes are essential in almost all biological processes and aberration of enzyme activity is implicated in many disease states. Therefore

modulation of enzyme function represents a well-researched route for drug development, a point underscored by the fact that enzyme

inhibitors represent almost half the drugs in clinical use today. Design, development and study of enzyme inhibitors continue to be a

major focus of pharmaceutical research. Therefore, this issue of PEPNET highlights this important area of research and includes key

articles devoted to proteasome and MMP inhibitors. We hope you will find our comprehensive collection of reagents for enzyme research

and custom synthesis services valuable for your innovations in this area.

Custom Synthesis ServicesPeptide aldehydes, ketones, hydroxy-isosteres

Cyclic compounds: termini / side chain / disulfide

Biotin, aminohexanoic acid, defined length PEGylations

Custom designed FRET substrates and libraries

Dabcyl, Dabsyl, Dansyl, EDANS, Farnesyl

Coumarin derivatives, Rhodamines, TAMRA

Glycosylated, Phosphorylated, Sulfated (Ser, Thr, Tyr)

Isotopically-labeled derivatives:

13C, 15N

Peptide International specializes in providing:

Exploratory compound sets and libraries

Multi-gram to pilot-scale preparations for

development and diagnosticsPlease contact our technical experts to discuss your specific

needs and to learn about our cost effective and value added

services.

A comprehensive list of Peptides International enzyme

inhibitors (The Enzyme Inhibitor Guide), complementary

substrates (The Enzyme Substrate Guide) and related

literature are available from www.pepnet.com or by contacting

us via email [email protected] or by phone 800-777-4779.

Crystal structure of TACE (TNF-a Converting Enzyme) in complex with inhibitor

TAPI-2 (TNF-a Protease Inhibitor-2). TAPIs are proprietary TACE inhibitors sold by

Peptides International under license from US Patents: 5,387,610; 5,616,605; 5686,422.

Source: http://www.ebi.ac.uk/pdbe-srv/view/images/entry/2ddf600.png by J. Swaminathan &

MSD staff at the European Bioinformatics Institute http://www.ebi.ac.uk/

Pennington Joins PI Team as CTO

Peptides International proud-ly announces the addition of Dr. Michael Pennington to the companys executive team as Chief Technical Officer effec-tive December 1st, 2010. Background

Dr. Pennington has spent over 20 years in research and devel-opment management with the Bachem Group and was most recently President and COO of Bachem Bioscience Inc., the companys King of Prussia (Pennsylvania) facility.

He is the author of nearly 100 technical publications,

has served on the editorial boards of several industry

journals, and is on the Scientific Advisory Boards of a

number of drug development companies. He is also

a co-principal investigator on several NIH grants and

serves as an adjunct faculty member in the Department

of Chemistry at Villanova University. Mike and his

wife Michelle have recently moved to Kentucky and

are enjoying their new property in horse country.

ChangesDr. Pennington's addition has had an immediate

impact at PI. Along with a broadened custom peptide

emphasis, many new initiatives, products, and quality

procedures have been introduced or implemented. At

the same time, Dr. Channa Basava, who had been lead-

ing the company's technical and commercial organiza-

tions, has expanded his efforts in the areas of specialty

products and technologies, business development, and

sales and marketing management.


Volume 24, No. 1, 2011


The custom peptide business has become com-

moditized in recent years as more and more low-cost,

quick turnaround sources appear around the world.

Yet researchers pursuing peptide-based drug devel-

opment projects increasingly seek more complex

structures and services that often exceed the capa-

bilities of many of these service providers. Peptides

International, with a long history of providing custom peptides, has

just completed a major commitment in personnel and equipment

that will allow it to satisfy the custom chemistry needs of the most

demanding researchers and their ever increasing challenges.

Addition of the new resources has resulted in the designation of

complex custom peptides as PIs newest Technology Platform (see

PEPNET Vol. 22 No. 2). This designation provides an integrated,

company-wide effort that not only meets customers immediate

synthetic needs, but can offer additional services in areas such as

analytical testing, technology/process development, and scale-up.

Leading this effort is Dr. Michael Pennington, a well-known peptide

industry expert with over 20 years of experience meeting just such

challenges (see inset). Joining Dr. Pennington and PIs existing

team of research, production, and QC scientists are Dr. Satendra

Chauhan and Dr. Rommel Talan (see page 2), who bring unique

breadth and experience to this team. PI laboratories, updated

and expanded in 2007, are now further enhanced with with state-

Growing AcCUSTOMed to New Challenges

PI Debuts New Technology Platform...

Dr. Michael PenningtonChief Technical Officer, Peptides International

Biotin

FITC

TMR

Linker

Not only is PI able to synthesize native ShK and custom analogs,but

our scientists can also attach labels such as fluorophores (TAMRA

and FITC) or Biotin with mini-PEGTM spacers, as shown.

Special

CUSTOM

Issue

ShK - A

35 amino acid peptide isolated from

the Caribbean sea anemone, Stichodactyla helianthus

see PI Debuts..., page 3

Lys-22

ShK

Arg-1

PRESORTEDSTANDARD U.S. PostagePAIDPEPTIDES INTERNATIONAL

P.O. Box 99703 Louisville, KY 40224-0658

USAAddress Service Requested

P.O. Box 99703Louisville, KY 40224-0658 USAPhone: 502-266-8787Fax: 502-267-1329



In This Issue

As in years past, we are including

a Kentucky Derby commemorative

glass with orders of $500 or more.

These glasses are highly collectable

and are often seen displayed during

visits to customers' labs and offices.

This year's edition will make a nice

addition (or start) to your collection. Order soon and don't

miss out! (No additional charge for shipping.)

By request and while quantities last. Limit one per laboratory,

please.

It's a Tradition: The 2011 Derby Glass

News and Notes

Going Beyond Custom Synthesis

Malemide-Activated KLH Carrier

Protein New Products from the Peptide

Institute Employee Spotlight(s)

This issue of PEPNET highlights Peptides International's recently

increased capabilities and offerings. We hope you enjoy perusing

this PEPNET edition. We look forward to hearing from you!

Coming Soon! Cell Penetrating Peptides, HDAC Products, New

Building Blocks/Synthetic Tools and much more.

The 22nd APS will be held June 25 - 30, 2011 in beautiful San

Diego, CA at the Sheraton Hotel and Marina in San Diego,

California.. Peptides International will be there and we hope you can stop by and say "hello"!

See You Soon...

20 th American Peptide Symposium On behalf of the American Peptide Society, we are pleased to invite you to the 20th

jubilee of the American Peptide

Symposium, "Peptides for Youth" to be

held in Montreal, Canada from June 26 to

30, 2007. This symposium will serve to

remember the accomplishments of society

members since Professors Saul Lande and

Boris Weinstein organized the First

American Peptide Symposium at Yale

University in 1968. Moreover, "Peptides

for Youth" will strive to attract Young Investigators to participate in a meeting that

recognizes and highlights their achievements, and incites their interests with a stimulating

scientific program, featured in a vibrant city, Montreal. The night life and quality of

entertainment in Montreal are world renown and by holding the Meeting around the

time of the Montreal Grand Prix and Montreal Jazz Festival, participants can enjoy

mixing quality Science with fast motorcar racing, great music and fun. Bilingual, multi-

cultural and safe, Montreal offers outstanding facilities, hotels, restaurants and

entertainment centers for a memorable meeting.

Co-chairs: Emanuel Escher William D. Lubell

Universit de Sherbrooke Universit de Montral For More Information Please Contact

[email protected] Coordinator: Susan Seaman (514) 343-6111 ext 3907

Peptides International would like to acknowlege two former

employees with whom many customers and researchers

have had contact over the years: Dr. DeAnna W. Long, who was Director of Business

Development, but during her tenure at PI wore many

hats, has moved on to a new role in academia.

Lisa Civello, who was Product Manager, has taken a

position in the non-profit sector in marketing.

They will be missed and we wish both of them well in their

future endeavors!Lastly, please note our recent mailing address change:

P.O. Box 99703

Louisville, KY 40224-0658

USAOur physical location address remains the same.

PEPNET.COM What's New Look for Peptides International at the APS 2011

TM

Look who's citing us!Literature citations of PI products & services!1,200 and counting...

PRA=Propargyl-Gly) while using the other with a labeling

molecule (e.g. Azido-PEG). The possibilities employing this

type of strategy allow for almost limitless selective label

incorporation. Peptides International now offers a new

assortment of these types of building block tools to aid in

the application of Click chemistry to many different systems.

Clickable Cell-Penetrating PeptidesCell-penetrating peptides (CPP) have received considerable

interest for drug discovery applications because of their abili-ty to permeate the cell membrane and allow for payload or cargo molecules to be deliv-ered into the cytosol. These peptides were initially discovered from the venom of wasps and the TAT (Trans-Activator of Transcription) protein derived from HIV. They typically have a high content of argi-nine residues. CPPs can be functionalized with alkynes or azido groups which allow for the transport of cargo molecules such as cytotoxic drugs, siRNA molecules or kinase inhibitor sequences. Peptides International is pleased to offer a new CPP derived from

HIV, TAT (49-57) (TAT-3733-PI, TAT-3734-PI, and TAT-3735-PI).


Volume 24, No. 2, 2011


What is Click Chemistry?Selective orthogonal labeling of peptides has

been limited by the need to use thiol and

amine groups in the target peptide to interact

with maleimido, halo-acetyl and NHS-esters

of the desired labeling molecule. When more

than one thiol or amine is present in a specific

peptide, it is difficult to get selective incorporation without

using special protecting groups to minimize side reactions.

Click chemistry, the name popularized by Nobel Laureate

Dr. Barry Sharpless of the Scripps Research Institute, involves

the incorporation of groups that other-wise do not occur in biological molecules into both the peptide and labeling mol-ecules. These groups then react - or "click", achieving high selec-tivity under mild conditions.

Clickable Building

Block ToolsThe most popular use of Click chemistry for biological molecules involves a cyclo-addi-tion reaction using an azido-containing component and an alkyne-containing component that react in the presence of Cu(I) to form a 1,4

disubstituted 1,2,3 triazole (see figure). For peptide chemistry applications, the

number of possibilities can be increased by incorporating

one of the respective components within a peptide chain (e.g.

Meet "The Clickables"

CLICK Chemistry

Issue

see Meet..., page 3

PRESORTEDSTANDARD U.S. PostagePAIDPEPTIDES INTERNATIONAL

P.O. Box 99703 Louisville, KY 40269-0703

Address Service Requested

P.O. Box 99703Louisville, KY 40269-0703 USAPhone: 502-266-8787Fax: 502-267-1329



In This Issue Meet "The Clickables" The Clickables: RGD Peptides NEW Feeding & Regulatory Peptides

New Items from the Peptide Institute

Advanced Equipment Installed Employee Spotlight(s)

This issue of PEPNET highlights Peptides International's entry

into the exciting area of Click Chemistry, as well as its use in cell

penetrating peptides, building blocks and RGD peptides. We hope

you enjoy perusing this PEPNET edition. We look forward to hear-

ing from you!Coming Soon! Toxins, Enzyme Inhibitors & Substrates and much

more.APS Wrap

Up: Thanks to all those who

stopped by and took time to visit the Peptides

International booth in San Diego. Also, con-

gratulations to Dr. Aleksandr Rabinovich,

at right, who was the winner of our Kindle

giveaway there. It was , by all accounts, a very

successful meeting. See you at Number 23!

CA Representation: Speaking of San Diego, please be aware

that PI has a business consultant dedicated to California. Dr.

Smita Yadav, at left, conveniently located in the San Diego

area, has many years of experience in the

peptide, chemistry and biology fields.

She would love to discuss your current

(or future) peptide projects and needs.

She can be reached directly by email at

[email protected], or by phone at 858-

361-4175. If you are located in California,

please contact Dr. Yadav today to discuss

the ways Peptides International can create value for your

peptide projects.

Benefits of Being Social: The

Peptides International page is

an up-to-the-minute resource

where you'll find all the latest

announcements, offers, and events related to Peptides

International and the field of peptide chemistry.

News and Notes

Peptides International Introduces New Product Line

Peptide CO

CHNH

2

CH2CH2C CH

N N N

[Cu]+

O

RKKRRQRRR NH2

+Alkyne Component

Azido-TAT Peptide (TAT-3734-PI)

"Clicked" TAT

CLICK

O

RKKRRQRRR NH2

CH CH2CH 2

CO

NH2

Peptide

NN

N

AzidoComponent

Alkyne-Containing Labeling Molecule

PEPNET.COM Stichodactyla Toxin (PSK-4287-s)

PEPNET.COM Stichodactyla Toxin (PSK-4287-s)

NP2D.COM Invited Speakers

Peptides International's Chief

Technical Officer, Dr. Michael

Pennington, is slated to be a keynote

speaker at the Natural Peptides To

Drugs 5th International Congress,

held from December 4 - 7, 2011, in

Zermatt, Switzerland. His topic,

Advancing ShK Peptide Into the Clinic for Treatment of Multiple

Sclerosis, has particular topicality for Peptides International:

ShK (Stichodactyla Toxin (PSK-4287-s)) is one of PI's extensive

toxins offerings. Following the conference, there will be

a "Conodays" event December 7 - 9. If you are attending,

please look up Peptides International while there! Look for

an in-depth review of peptide toxins in the next edition of the

PEPNET newsletter.

PI CTO @ NP2D (translation below)2D

NP

Scan here for a special offer!

Purchasing

xx Order Hotline 1-800-777-4779 502-266-8787

Peptides International's customer service representatives are prepared to help process your orders, assist with product information, and answer technical questions. Orders can be placed by mail, telephone, fax, or email.

Address: Mailing Address Physical AddressPeptides International or Peptides InternationalP. O. Box 99703 11621 Electron DriveLouisville, Kentucky 40269-0703

Louisville, Kentucky 40299-3861

USA USA

Telephone: 1-502-266-8787 (Local and International Callers) 1-800-777-4779 Toll-free (USA and Canada) Customer service representatives are available during the following times to

assist you: Monday through Thursday - 8:30 AM - 6:00 PM (EST / EDT time) Friday - 8:30 AM - 5:00 PM (EST / EDT time)

Fax: 1-502-267-1329 Email: [email protected]

Web site:

Purchasing

Order Hotline 1-800-777-4779 502-266-8787 xxi

OrdersWhen placing an order please specify: Customer ID Number Company or Institution Billing Address Shipping Address Purchase Order Number or

Credit Card information Catalog Code Number Quantity and Product

Description Quote Number, if applicable Telephone Number Fax Number Email Address Shipping Requirements VAT, if applicable

Minimum OrdersPeptides International does not require a minimum order but encourages repeat customers to combine small orders, when possible, to minimize handling and shipping costs.

Confirming OrdersPlease mark all confirming orders clearly to avoid duplication.

Back OrdersShould an item be temporarily out of stock, this will be indicated in the back order column of the customers invoice. Most back order are shipped within two weeks.

Using the Catalog

xxii Order Hotline 1-800-777-4779 502-266-8787

Catalog Key This catalog has been designed to provide unique, concise information for

each product, with the intention of enabling easy navigation and ordering. For further information or specific questions regarding a product, please

contact a Peptide International customer service representative.Biologically Active Peptides (All Are Acetate Form Unless Otherwise Indicated)

1. Major Product Section, designated as Biologically Active Peptides, Enzyme Inhibitors & Substrates, Specialty Products & Technologies, or Tools for Peptide Synthesis.2. Subsection Heading 3. Product Section (may include article and / or references)4. Product Name5. Product Code6. Unit Size7. Price (in US Dollars)

8. Alternate Name (when applicable)9. Storage Temperature (see page for key)10. Synthetic, Originally From... (when applicable) 11. Sequence (when applicable/available)12. Molecular Weight, Formula, and CAS Number (when available)13. Description (when applicable/available) 14. References (when available)

Peptides International strives to give accurate content, including product information, quantities, and pricing. Policies, pricing, and item availability are subject to change without notice. While Peptides International makes a good faith effort to ensure that the information displayed is accurate, we are not responsible for typographical errors or technical inac-curacies.

Toxinsw-AgatoxinsB.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review) O.D. Uchitel, Toxicon, 35, 1161 (1997). (Review)

-Agatoxin IVA -Aga-IVA(Funnel Web Spider, Agelenopsis aperta)

PAG-4256-s-20 C

0.1 mgvial

380

Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala (Disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34) (M.W. 5202.2) C217H360N68O60S10 P-type Ca2+ Channel Selective BlockerI.M. Mintz, V.J. Venema, K.M. Swiderek, T.D. Lee, B.P. Bean, and M.E. Adams, Nature, 355, 827 (1992). (Original) T.J. Turner, M.E. Adams, and K. Dunlap, Science, 258, 310 (1992). (Pharmacol.) H. Nishio, K.Y. Kumagaye, S. Kubo, Y.-N. Chen, A. Momiyama, T. Takahashi, T. Kimura, and S. Sakakibara, Biochem. Biophys. Res. Commun., 196, 1447 (1993). (Chem. Synthesis & Biological Activity) This compound is distributed exclusively through Peptides International under license agreement with the University of Utah.

95

11

12

1413

12

3

48

7

10

6

Order Hotline 1-800-777-4779 502-266-8787 xxiii

Applicable TermsThese Terms and Conditions of Sale shall become part of every order, sale, and purchase agreement between buyer and Peptides International.With the placement of an order, the buyer agrees to accept the Terms and Conditions of Sale. Peptides International shall not be bound by the purchasing conditions of the buyer, even if not explicitly stated. Orders containing addenda or statements that are worded differently or provide for further condi-tions will not be accepted unless spe-cifically agreed to in writing by Peptides International.The UN Convention on the International Sale of Goods shall not apply.

QuotationsQuotations must be requested for the following special situations: Custom synthesis of materials not listed in Peptides Internationals website or catalog (custom quotations) Quantities of specific materials that exceed those listed in Peptides Internationals website or catalog (bulk quotations) Packaging alternatives, such as custom vialing, that are not offered in website or catalog listings Large purchases of multiple items where a discount is requested (core quotations)Unless otherwise stated, quotations are valid for 30 days from date of issue.Quotation prices are valid only for indi-cated product(s) in the quantity, quality, salt form, and lead time specified in the quotation. Lead times for custom quotations are from date of receipt of an approved purchase order. Lead times for catalog products are subject to inventory status on date of receipt of an approved pur-chase order.Quotations are considered confidential

Terms and Conditions

xxiv Order Hotline 1-800-777-4779 502-266-8787

and are specific to the product(s) and customer. If appropriate, Non Disclosure Agreements may also be requested. Quotations are not transferable to other parties without express permission from Peptides International. Purchases based on accepted quota-tions remain subject to all other Terms and Conditions of Sale.

PricesAll prices are quoted in US Dollars and do not include value-added and/or sales tax, which may be invoiced separately as required. Prices include inner and outer packaging unless specifically noted oth-erwise. If the prices in Peptides Internationals printed literature vary from the prices published on the Peptides International website (www.pepnet.com), then the prices on the website shall prevail.Shipping and handling charges apply to all shipments and Peptides International reserves the right to add a surcharge for any special shipment requirements (e.g. dry ice, inert gas).All product prices are subject to change without notice prior to confirmation of an order, but no product will be shipped at increased prices without prior notifica-tion. Peptides International reserves the right to charge a re-assaying and restocking fee on returned goods.

Order PlacementOrders may be placed by telephone, fax, email, letter or online using Peptides Internationals website (www.pepnet.com).

Orders resulting from a prior quotation must reference the specific quotation number. Orders placed verbally or by electronic transmission shall become legally bind-ing only if they have been confirmed by receipt of an invoice number from Peptides International. Orders received by Peptides International are firm and binding upon the buyer and do not release the parties from their obligation(s) to deliver or to accept deliv-ery, nor release them from their financial obligations to Peptides International. Custom orders should be reviewed carefully for structures, sequences, and other particulars before placing orders. Peptides International may at its discre-tion accept change orders under condi-tions that provide for recovery of already incurred costs and any additional costs arising from the agreed upon changes.

Delivery and AcceptanceAgreed upon delivery deadlines refer to the shipment date of the goods. If the delivery deadline is extended by buyer, buyer shall specify an appropri-ate period for acceptable late delivery of the shipment. If the delivery deadline is extended by Peptides International, buyer will be notified of such extension prior to the original shipment deadline. Peptides International reserves the right to decline orders in the event the product can no longer be made or the customer is in arrears with any commitments or payments.Buyer is responsible for complying with national or international laws or regula-tions applicable to shipment, delivery, storage, processing or trading of any


Order Hotline 1-800-777-4779 502-266-8787 xxv

specifically designated products.Force majeure of any kind, unforesee-able operational disruptions, short-falls or failures in delivery by Peptides Internationals suppliers, shortages of raw materials, power supplies and/or manpower, strikes, lockouts, problems in procuring means of transport, traffic obstructions, war, political unrest, acts of terrorism, natural disasters and order of higher authorities exempt the party concerned from the obligation to deliver or to accept delivery for the duration of the disruption and for any consequential damages arising therefrom, but shall not exempt such party from any financial obligations arising from any goods or services already supplied.

Warranty and Warranty DisclaimerAll Peptides International biochemicals are extensively tested for purity. Each shipment is accompanied by a detailed lot-specific Analytical Data Sheet (ADS). Peptides International warrants the purity, identity and content of its prod-ucts at the time of sale in accordance with the results listed in the ADS. The buyer shall visually inspect and test products immediately upon receipt to determine whether the condition and quantity of the goods conforms to the ADS and the applicable contractual agreement. All claims must be received in writing within 14 days from date of delivery of the product to the customer and failure to do so shall constitute a waiver by buyer for any and all such claims. Claims must include proof of non-compliance, specifically naming the product, the lot number, and the invoice number.

Peptides International shall ship replace-ment product for claims for which proof is submitted and which are received within the time period specified above. If the replacement delivery is also non-con-forming to the contractual agreement, then the buyer has the right to cancel the order or contract. Products that are the subject of com-plaint may be sent back only with Peptide Internationals agreement and shipping arrangements for the return must be agreed upon by both parties in advance. Peptides Internationals sole obligation is to replace material up to the extent of the purchase price, or provide a refund or credit. Peptides International makes no other warranties, express or implied, including, but not limited to, any implied warranty of merchantability or fitness for a particular purpose or implied warranty arising out of a course of dealing, cus-tom, or usage of trade.

Use and Limitation of LiabilityAll products sold by Peptides International are intended solely for laboratory and research use and should not be used in or on human subjects. Peptides International sup-plies such products only for the pur-poses of public research as conducted at experimental and teaching institutes, technical facilities and commercial enti-ties.It is the responsibility of the buyer to determine the adequacy of all materials for any intended or specific purpose or use. Peptides International makes no warranties as to use for an intended or specific purpose.


xxvi Order Hotline 1-800-777-4779 502-266-8787

Peptides International expressly forbids the distribution of dangerous substances to private individuals and draws atten-tion to the fact that the absence of a hazard warning sign does not indicate that the product concerned is harmless. Peptides International shall therefore not accept any liability for damage that could arise from the inappropriate handling or from any use in household applications or in humans and animals. Peptides International shall not be liable for any damage as a result of improper use or storage of its products. This limitation of liability also includes products that have been tampered with or altered by accident or negligence. Peptide Internationals liability with respect to non-fulfillment or delay of delivery shall be limited to the invoice amount of the goods. All information contained in catalogs, brochures, publications and other printed or electronic media is compiled to the best of Peptide Internationals knowl-edge. Peptides International hereby disclaims any liability for any possible errors or misprints. Peptides International shall not under any circumstances be liable to buyer for any direct, indirect, special, incidental, or consequential loss or damages (includ-ing, but not limited to, loss of profits, revenue, business, research, research results, opportunity or goodwill) aris-ing from or in any way related to the products or Peptides Internationals sale of products, regardless of the legal or equitable theory under which such loss or damages are sought, including breach of warranty or contract, negligence, or strict liability.

Title and Proprietary RightsUntil full payment of the purchase price, including all secondary claims, the sup-plied products remain the property of Peptides International (reservation of title). If the buyer fails to pay for products despite receipt of late notices, Peptides International reserves the right to with-hold any further deliveries to the buyer and to require the return of the unpaid goods, unused and in original packag-ing, at the buyers expense.

Terms of PaymentTerms of payment are net 30 days for qualified buyers. A service charge of 1.5% per month (18% ANNUAL RATE) will be added to all balances which are 30 or more days past due. Discount deductions on invoices are not allowed. Reductions in Peptides Internationals invoices may not be made without a credit invoice or note and if made without such, shall be considered a late or short payment. Peptides International reserves the right to change the terms of payment to payment in full or in part in advance of shipment. After an order is accepted or a sale com-mitment is made, any increase in, and all new taxes, excises, duties, or other governmental charges (except taxes on income) imposed on the production, sale, transportation, import or export of products sold to buyer which Peptides International is required to pay will be added to the price paid by customer for products.


Order Hotline 1-800-777-4779 502-266-8787 xxvii

Payment may be made by one of the following methods: Check: Send a check, including

any clearing, processing, or other bank charges or fees to: Peptides International, Inc.P.O. Box 99703Louisville, KY 40269

Wire Transfer: If not already in US dollars, arrange for conversion of the currency to US dollars, includ-ing shipping and handling charges (included on all invoices). Wire the total amount to the following account:Bank ABA # 083900680Account # 5183479840SWIFT # BRBTUS33BB&T401 West Main St.Louisville, KY 40202 USA Contact: Nell Prince Phone (502)-562-7902

Credit Card: Peptides International accepts MasterCard, Visa, and American Express.

Important: After completing one of the steps above please email or fax a con-firming note to Peptides International indicating the date and amount of your payment. You should also include your invoice number or purchase order num-ber to insure proper credit.

Patent Claims, Protection Rights, Consultancy

With any purchase, the buyer acquires the product but no other rights asso-ciated with the product. Peptides International remains in possession of all intellectual property rights related to the manufacturing and composition of the product. The use of trademarks in offers does not provide for the use of such trademarks. Permission for such use must always be obtained from Peptides International in advance and in writing. Peptides International makes no guaran-tee that the use or resale of its products will not violate the protection or patent rights of third parties. Peptides International agrees to offer its customers technical support to the best of its knowledge. All comments or proposals for the use, application, or suitability of the products shall not be interpreted as an explicit guarantee of success.

Applicable Laws Any legal dispute involving these Terms and Conditions will be governed by the laws of the Commonwealth of Kentucky.If a provision in these conditions of sale or a provision in the context of other agreements are or become legally unenforceable, only that provision shall become null and void and all remaining provisions shall remain enforceable and in effect.


xxviii Order Hotline 1-800-777-4779 502-266-8787

Custom Products and ServicesIf peptides or other products you need are not listed in this catalog, we invite you to try our custom synthesis services. Peptides International has earned the reputation of providing exceptionally high quality custom peptide synthesis products to the research community. We specialize in 5 to 100 mg quantities (or greater) with purity levels of at least 95%. Amino acid analysis ratios, mass spectral data, and analytical HPLC chro-matograms are provided with custom peptides. Areas of expertise include: Multi-Disulfide PeptidesInterested in mini-proteins with multiple disulfide bonds? Peptides International researchers have extensive experience folding these highly complicated molecules to their biologically active forms. Examples include native molecules and analogs of conotoxins, defensins, hepcidins, chemokines, ion channel blockers (ShK, HwTX4, charybdotoxin, iberiotoxin, margatoxin, ProTx-II, mu-conotoxins, etc). They can also customize with labels such as TAMRA, FITC or Biotin using a mini-PEG spacer.Peptide-Protein ConjugatesPeptide-protein conjugates have a variety of applications, including the stimulation of antibodies for immunization. These conjugates can be customized as needed, includ-ing combinations with proteins such as Albumin, Ovalbumin, and Ferritin. Selective het-erobifunctional crosslinkers allow for selective attachment of a Cys-containing peptide to the protein of your choice. Using KLH-MCC will help streamline this reaction, and the product (KLH-6000-PI) is conveniently kept in stock at all times.Peptide DerivativesFluorescence resonance energy transfer (FRET) occurs when excitation energy is transferred from an excited fluorescent donor to a quenching acceptor in a distance-dependent manner. Cleavage of a scissile peptide bond within a fluorescence quenched substrate leads to separation of the intramolecular donor-acceptor pair, thus allowing an increase in fluorescence. The fluorescence increase is proportional to the amount of peptide hydrolyzed. To design a substrate for a newly discovered enzyme

Custom Peptide Synthesis

Order Hotline 1-800-777-4779 502-266-8787 xxix

or application, contact our specialists to begin a customized Substrates by Design project.Post Translation ModificationIncluding: Glycosylation, Phosphorylation, Fatty Acid Acylation, Pegylation, Cyclization, and Disulfide BondsPeptide SynthesisIncluding: Classical/Solution, Solid-Phase, Native Chemical Ligation, and Dendrimeric RGD PlatformsPeptidomimeticsIncluding: Hydroxyethylene Isostere, Reduced Peptide Bonds, Aldehydes, Chloro-methylketones, Depsipeptides, and PhosphonatesMulti-step Organic SynthesisIncluding: Novel Amino Acid Derivatives, Stereo Selective Synthesis, Special Protecting GroupsOther ServicesPeptides International is an excellent source for production of unusual amino acids and offers rapid, thorough, and cost effective hydrogen fluoride (HF) cleavage proce-dures. Please inquire for additional analytical services. ConfidentialityAll customer requests will be treated with strict confidentiality and non-disclosure agreements can easily be put in place. We offer molecular design consultations, project management and technology transfer for scale-up production.

Custom Peptide Synthesis

Order Hotline 1-800-777-4779 502-266-8787 xxx

Technology Platforms

As additional value, Peptides International has developed technology platforms that assure an intergrated company-wide effort that not only meets researcher's immedi-ate synthetic needs, but can offer additional services in such areas as analytical testing, technology/process development, and scale-up. Peptides International's RGD Technology Platform, is a natural outgrowth of its extensive catalog offerings, custom RGD experience, and technological expertise.

T e c h n o l o g y P l a t f o r m

RGDComplex Organic

Derivatives

MultimersConjugates

Industry Leading Catalog Portfolio

Defined-Length PEGylations

Process Scale-up Multi-gram Synthesis

Applications and Potential Benefits to Researchers: Integrin related RGD research NCEs and cancer drug development Useful to prepare radiolabeled agents

Tumor targeting, imaging and diagnostics Novel biomaterial research & development Tissue repair and wound healing studies

xxxi Order Hotline 1-800-777-4779 502-266-8787

Technology Platforms

The Custom Services Portfolio Platform spans a wide range of technologies rang-ing from traditional solution and solid phase synthesis to peptidomimetics as illus-trated by depsi-peptide bond formation and HET isostere incorporation. Expertise in multi-step organic synthesis and peptide modi-fication offer a virtually limitless range of custom options extending from glycosylation to fluorescent and isotopic labeling, cyclization, phosphorylation, and more.

Peptidomimetics

Post TranslationalModifications

Multi-disulfidePeptides

PeptideSynthesis

Multi-stepOrganic

SynthesisPeptide- Protein

Conjugates

Peptide Derivatives

PEPTIDES INTERNATIONALBIOLOGICALLY

ACTIVE PEPTIDES

Order Hotline 1-800-777-4779 502-266-8787 1

PRODUCT CODE QTY PRICE Biologically Active Peptides (All Are Acetate Form Unless Otherwise Indicated)Ac-Asp-GluAc-Asp-Glu H2O (Bulk)

(M.W. 304.26 18.02) C11H16N2O8 H2O [3106-85-2]Endogenous Excitatory Neurotransmitter

PDE-4167-20 C

25 mg100 mg

55155

K.L. Reichert and F. Fonnum, J. Neurochem., 16, 1409 (1969). (Original) K.J. Koller and J.T. Coyle, Eur. J. Pharm., 98, 193 (1984). (Characterization of Receptor) K.J. Koller, R. Zaczek, and J.T. Coyle, J. Neurochem., 43, 1136 (1984). (Localization in Brain)J.H. Neale, T. Bzdega, and B. Wroblewska, J. Neurochem. 75, 443 (2000). (Review)

ACV (Delta-(l-Alpha aminoadipyl)-l-Cysteinyl-Bis-d-Valine)Bis-ACV

Delta-(l-a-aminoadipyl)-l-Cysteinyl-Bis-d-Valine (M.W. 724.86) C28H48N6O12S2Precursor for Biosynthesis of Penecillin

PAC-3860-PI-20 C

25 mg100 mg

395995

Adjuvant PeptideAdjuvant Peptide

N-Ac-Mur-Ala-d-Glu-NH2 (Mur: Muramic acid) (M.W. 492.48) C19H32N4O11 [53678-77-6]

PAD-4031-v-20 C

0.5 mg vial

45

Adjuvant Peptide (Bulk) N-Ac-Mur-Ala-d-Glu-NH2 2H2O (Mur: Muramic acid) (M.W. 492.48 36.03 ) C19H32N4O11 2H2O [53678-77-6] Muramyl Dipeptide

PAD-4031-20 C

25 mg 850

F. Ellouz, A. Adam, R. Ciorbaru, and E. Lederer, Biochem. Biophys. Res. Commun., 59, 1317 (1974). (Original) S. Kotani, Y. Watanabe, F. Kinoshita, T. Shimono, I. Morisaki, T. Shiba, S. Kusumoto, Y. Tarumi, and K. Ikenaka, Biken J., 18, 105 (1975). (Chem. Synthesis and Immun. Activity)

Adrenocorticotropic Hormone (ACTH)

ACTH (Human, 1-24) Adrenocorticotropic Hormone (Human, 1-24)

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val- Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro (M.W. 2933.4) C136H210N40O31S [16960-16-0]

PAC-4109-v-20 C

0.5 mg vial

275

B. Riniker, P. Sieber, W. Rittel, and H. Zuber, Nature (New Biol.), 235, 114 (1972). (Original; Structure)

2 Order Hotline 1-800-777-4779 502-266-8787

PEPT

IDES

INTE

RNAT

IONA

LBI

OLOG

ICAL

LY AC

TIVE

PEP

TIDE

S PRODUCT CODE QTY PRICE Adrenomedullins and Related Peptides

K. Kitamura, K. Kangawa, H. Matsuo, and T. Eto, Drugs, 49, 485 (1995). (Review) D.A. Schell, R.C. Vari, and W.K. Samson, Trends Endocrinol. Metab., 7, 7 (1996). (Review)M. Julin, M. Cacho, M.A. Garcia, S. Martin-Santamaria, B. de Pascual-Teresa, A. Ramos,

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