personal care active...
TRANSCRIPT
QD Permitted to be used as quasi-drugs in Japan. QD status is depending on products, contact us for details.QD* IECIC2015 Listed in the Inventory of Existing Cosmetic Ingredient in China 2015.
Anti-aging❶
StemCell
Sugar
Sugar
Tobacco Smoke UVVehicle
Emission
Collagen
TA-StemCell
TryptaseBasementMembrane
Mast Cell
AhR-CYP
Melanocyte
NoticeablePore
*AhR : Aryl hydrocarbon Receptor CYP : Cytochrome P450
Keratinocyte(Keratin)
Lymphatic capillary
Waste productsFluid retention
Draining disorder
PM 2.5
Blue LightKeratinocyte
DAMPsKeratinocyte(KC)
OUGON Liquid B/G<Scutellaria Baicalensis Root Extract>
PrincessCare /G<Geranium Robertianum Extract>
❻CUREPASSION /G<Passi�ora Edulis Fruit Extract>
❺ Lymphatic Care
Prevention of Environmental Pollution
❸ Minimizing Noticeable Pore
Protection of Basement Membrane
Absorage<Plantago Major Seed Extract>
Preventing glycation
IZAYOI /G<Rosa Roxburghii Fruit Extract>
Inhibiting DAMPs response on KC
Improving dermal lymphatic system
Inhibiting AhR-CYP
Inhibiting tryptase
Protection of Skin Protein❹
Biobene�ty /G/HS<Cynara Scolymus (Artichoke) Leaf Extract>
❶
Suppression of Erythema Caused by UV rays ❷Inhibiting NF- B κ
1
Inhibiting DAMPs response on KC
In the trial for smoker or passive smoker, OUGON Liquid B recovered wrinkles.
After the application of 3% PrincessCare solution for 12 weeks, the wrinkle signi�cantly diminished.
PrincessCare /G
PrincessCare inhibits tryptase activity and prevents extracellular matrix degradation as well as basement membrane damage leading to perfect anti-photoaging care.
<Geranium Robertianum Extract>
OUGON Liquid B/G
Inhibiting AhR-CYPPollutants, such as PM2.5 activates AhR-CYP signal which induces expression of collagenase MMP-1 and promotion of in�ammation mediator IL-8 (�gure to the right), and leads to skin wrinkles and pigmentation.
DAMPs (damage-associated molecular patterns) are released when cells are damaged by UV rays. DAMPs are involved in the uppermost stream of the skin aging route. DAMPs-like substance Poly (I:C) was added to cultured keratinocytes. IZAYOI suppressed the expression of IL-8 mRNA dose-dependently.
Inhibiting tryptase
Basement Membrane
Breakdown of the Basement Membrane by Tryptase
Protection of the Basement Membrane by PrincessCare
<Scutellaria Baicalensis Root Extract> <Rosa Roxburghii Fruit Extract>
50’s Smoking Female (Japanese) 2% OUGON Liquid B
❶ Prevention of Environmental Pollution ❷ Suppression of Erythema Caused by UV
❻ Protection of Basement Membrane
Before After 2 months
Before After 2months80
90
100
Ratio
of w
rinkl
e d
epth
(%)
Control
2% OUGON Liquid B
60
80
100
120
140
Before After 12weeks
Ratio
of w
rinkl
e ar
ea (%
)
3% PrincessCare
Control
IECIC2015
IECIC2015
IECIC2015
0 1 2 3 4
0 20 40 60 80 100
***
***
**
non-PM2.5
Control
0.01%OUGON Liquid B
0.2%OUGON Liquid B
Relative IL-8 mRNA Expression
*** : p<0.01, ** : p<0.05
***
*** : p<0.01 vs. Before
QD*
Biobene�ty /G/HS<Cynara Scolymus (Artichoke) Leaf Extract>
❸ Minimizing Noticeable Pore
NF-κB activation causes hyperproliferation of keratinocytes to enlarge pores and increases in the melanin production of melanocytes causing to darken pores.
Biobene�ty minimized noticeable pores through NF-κB inhibition.
20’s Female (Japanese)
After 2 months
N o t i c e a b l e pores indicated red dots were decreased.
Before
5% Biobene�ty
0 1 2400
500
600
Pore
num
ber
5% Biobene�ty
Control
Month
*** : p< 0.01 vs. 0 month
IECIC2015
QD*
Preventing glycation
Dihydroxyacetone(DHA) solution stains the skin by glycation. Absorage prevented skin browning by glycation of skin protein.
Plantagoside, the active compound of Absorage, prevented glycation of keratinocyte protein.
❹
Glycation of proteins in the skin causes aging of the skin such as loss in clarity, lowering of elasticity or resiliency and wrinkles.
Absorage<Plantago Major Seed Extract>
Protection of Skin Protein
Control
DHA Conc.
1%
0.5%
Absorage
40’s Male (Japanese)
Plantagoside 10 μmol/L
L-Lysine 100 μmol/L
Inhibition ratio of glycation (%)
GlycationInhibitors
Aminoguanidine Sulfate 100 μmol/L
Equivalent to Absorage 0.93%
QD IECIC2015 ❺
emImproving dermal lymphatic system
Main function of lymphatic vessel system is to collect wastes and excess water. But they are known to impair in their function by UV rays. CUREPASSION enhances lymphatic tube-like formation by lymphatic endothelial cells and improved of facial puffiness.
CUREPASSION /G<Passi�ora Edulis Fruit Extract>
Control
1% CUREPASSION1% CUREPASSION
Lymphatic Care
Lymphatic tube-like formation
IECIC2015
30’s Female (Japanese)
ControlThe white part shows the face line before.
After 8weeks
IZAYOI /G
Control0
1020304050
Rela
tive
IL-8
mRN
A
Expr
essi
on
IZAYOI0.04% 0.2% 1%Non
Poly(I:C)
Inhibition of DAMPs response on KC
*** : p<0.01 vs. Control
Addition of Poly(I:C)
******
******
Control 2% IZAYOI
24 hours after sunbathing
Erythema
After sunbathing 2% IZAYOI lotion were applied on the face for 7 days. Erythema was d e t e c t a b l e a t t h e control applied area, but was not at the IZAYOI applied area.40’s Male (Japanese)
QD*QD
** : p<0.05
**
Inhibiting NF- B κ
2
QD Permitted to be used as quasi-drugs in Japan. QD status is depending on products, contact us for details.QD* IECIC2015 Listed in the Inventory of Existing Cosmetic Ingredient in China 2015.
UV
BasementMembrane
TurnoverKeratinocyte(KC)
KeratinocyteEndothelin-1
Melanocyte Melanocyte
MelaninKinesin
Melanosome Transfer
Stagnant Melanin
Alpiniawhite /HS
Mediators for Melanogenesis
KIWI Liquid B<Actinidia Chinensis (Kiwi) Fruit Extract>
MandarinClear /HS<Citrus Reticulata (Tangerine) Peel Extract>
Melanin Synthesis Activation
<Alpinia Katsumadai Seed Extract>
Biobene�ty /G/HS<Cynara Scolymus (Artichoke) Leaf Extract>
❶ Inhibition of Melanogenesis Mediators
Brake on Melanin Production❷ Suppression of Melanin Transport❸CinderellaCare<Thymus Serpyllum Extract>
Rejection of Melanin❹Clairju<Hydrolyzed Prunus Domestica>
Melanosome Tranport in Cell
❺
Increase Clarity / Internal Re�ection❻
Dullness / Scattering Light
Discharge of Stagnant Melanin
Age Spots / Brightening / Clarity
3
IECIC2015
QD
QD
IECIC2015
QD IECIC2015
QD IECIC2015
IECIC2015 QD IECIC
2015
QD*
5% Alpiniawhite
Age spots are decreased !30’s Male (Japanese)
Before After (4 weeks)1% Alpiniawhite
Melanin particleswere accumulated
Clairju
Clear skin with smooth surface
Before
Control
1% CinderellaCare
Before
After (2 weeks)
30’s Female
After (4 weeks)
Fluorescent Particles (Pseudo melanin)
0.5% CinderellaCare
0 40 80 120 160Endothelin-1 production (pg/mL)
Non-UV
Control
***
***
Control
0 1 2 3150
200
250M
elan
in In
dex
Month
***
***
Whitening e�ect on human skin
*** : p<0.01 vs. 0 month
*** : p<0.01
** : p<0.05
5% Biobene�ty Control
Control
Before
After (4weeks)
30’s Female (Japanese)
"Frosted glass" like
"Transparent glass" like
1% MandarinClear1% MandarinClear
Reduction of Scattering
light
0.5%Biobene�ty
+1% KIWI Liquid B
0 50 100 150 200 250
KC intaked melanin
+2% KIWI Liquid B**
**
**
Acceleration ratio of cell division (%)
Normal KC
30’s Female (Japanese)
Age spots are decreased !
Before1% KIWI Liquid B
After (4 weeks)
❹
Biobene�ty /G/HS
Control of NF- B activity guardsskin against pigmentation
κ
Clarity and shine that comes from within the skin
<Cynara Scolymus (Artichoke) Leaf Extract>
❶ Inhibition of Melanogenesis Mediators
CinderellaCare<Thymus Serpyllum Extract>Suppression of melanin migration within melanocytes
❸ Supression of Melanin Transport
Rejection of Melanin
Alpiniawhite /HSThe new mechanism of whitening “Melanogenic Brake”
↑Decreased age spots after application of 1% Alpiniawhite for 4 weeks.
<Alpinia Katsumadai Seed Extract>
←Decreased melanin particles in stratum corneum after application of 5% Alpiniawhite for 42 days.
❷ Brake on Melanin Production
ClairjuThe new mechanism of whitening “Melanin Diet Theory”
Phagocytosis (eating of cells) of keratinocytes was observed with �uorescent beads (alternative to melanosomes). Clairju clearly inhibited keratinocytes ability to absorb the �uorescent beads.
<Hydrolyzed Prunus Domestica>KIWI Liquid B<Actinidia Chinensis (Kiwi) Fruit Extract>
❺
1% MandarinClear was applied on test subjects' cheeks twice a day for 4weeks, MandarinClear reduces scattering lights and improved light transparency (photo to the right), signi�cantly improved the brightness of skin (photo below) .
In melanocyte that CinderellaCare was added to, kinesins activities were suppressed so melanosomes were not carried (photo above).1% CinderellaCare was applied on one side each of the face of 21 male and female. In CinderellaCare applied area, the melanin index signi�cantly lowered and the number of dark spots reduced.
Biobene�ty inhibited the production of endothelin-1 which could mediate the melanogenesis (�gure to the left). After the application of lotion containing 5% of Biobene�ty, melanin index of skin were improved (�gure to the right).
MandarinClear /HS<Citrus Reticulata (Tangerine) Peel Extract>
Increase Clarity / Internal Re�ection❻
New whitening theory “Discharge of Stagnant Melanin”
Discharge of Stagnant Melanin
After the application of lotion containing 1% of K I W I L i q u i d B f o r 4 weeks, melanin index of skin were improved a n d p i g m e n t s p o t s were decreased.
K I W I L i q u i d B h a s b e e n con�rmed to have an e�ect to p r o m o t e t h e d i v i s i o n o f keratinocytes intaking melanin (melanin �lled basal cells).
4
QD Permitted to be used as quasi-drugs in Japan. QD status is depending on products, contact us for details.QD* IECIC2015 Listed in the Inventory of Existing Cosmetic Ingredient in China 2015.
Sensitive Skin Care / Soothing
Keratinocyte
IL-1α
NGF
Skin bacteria
Mastcell
Peripheral nerve
Environmentalpollution
Fibroblast
Langerhans cell
Corneocyte
Dry environmentMechanical stress
PAR2
HistamineTryptase, ..etc.
Barrier dysfunction
In�ammation
Irritation due to bacteria and its metabolites
Nerve stimulation factor(Mastcell)Conduction of impulse
(Itching)
❷Dermaveil<Salix Alba (Willow) Bark Extract>
Maturation of Skin Cells
COMFREY Liquid B<Symphytum O�cinale Leaf Extract>
BOTANPI Liquid B<Paeonia Su�ruticosa Root Extract>
Soapnut Extract Powder<Sapindus Trifoliatus Fruit Extract>
YUZU Ceramide B<Citrus Junos Fruit Extract>
Dyskeratosis
❻ Inhibiting Histamine Release
❹ Inhibiting Inflammatory MediatorSAKURA Extract B<Prunus Yedoensis Leaf Extract>
❺ Anti-Inflammation
Gentle Cleansing❸
In�ammatory mediator
❶ Improvement of Barrier Function
5
■
Ceramide from citrus fruit
Inhibiting Histamine Release❻
0 0.2 0.4 0.6 0.8 1.0
20
40
60
80
100
GK2
Comfrey extractComfrey extractBOTANPI
LiquidBOTANPI
Liquid
0
■■
▲▲▲▲
0 0.5 1.0 1.5 2.0
Standard hair color
Erythema index (point)
Reducing skin irritation
COMFREY Liquid B<Symphytum O�cinale Leaf Extract>
sePowerfully inhibiting histamine release and reducing chemical dermatitis
IInhi
bitio
n ra
tio o
f hi
stam
ine
rele
ase
(%)
Concentration (%)
Concentration (%)
IInhi
bitio
n ra
tio o
f hi
stam
ine
rele
ase
(%)
Hair color combined with1.5% COMFREY Liquid B
COMFREY Liquid B reduced contact dermatitis by hair color.
Comfrey extract suppressed histamine release strongly.
Suppressing histamine release very strongly
Cromolyn (Mast cell stabilizer)
Activation of PPAR-β/δthe latest strategy against dry skin
Dermaveil<Salix Alba (Willow) Bark Extract>
Maturation of Skin Cells❷
Abnormal keratinocyte maturation (corni�ca-tion) induces the dry skin or sensitive skin. Dermaveil activates the intranuclear receptor “PPAR-β/δ” which is one of the important key factors of corni�cation.Dermaveil enhanced CE production in keratino-cyte and improved the skin roughness induced by sodium lauryl sulfate (SDS) in human skin.
0.5%Dermaveil
Control
5% BOTANPILiquid
Control
1.0%Dermaveil
CE production (relative ratio)
***
**
0 1 2 3
*** : p<0.01, ** : p<0.05
Control
3% Dermaveil
SDS-damaged skin
Anti-Inflammation❺
SAKURA Extract B improved the erythema (skin redness) induced by 5% sodium lauryl sulfate (SDS) solution in human skin.
BOTANPI Liquid suppressed histamine release relatively strongly.
BOTANPI Liquid well suppressed the production of IL-1α from keratinocytes by ultraviolet light.
●●
●●●●●●●●● ●●●
0 10 12 14-5
-4
-3
-2
-1
0
1
VAS
itch
scal
e (c
m)
Day2 4 6 8
SAKURA Extract B decreased usually skin itchiness over time and it has also improved the state of the stratum corneum.
Decreasing itching over time
2% SAKURA Extract B
●
Improving erythema
SAKURA Extract B<Prunus Yedoensis Leaf Extract>
Suppressing erythema and itching by excellent anti-in�ammatory
Excellent anti-in�ammatory
ControlSAKURA Extract B
Gentle Cleansing❸
Gently cleanses the skin without damaging
<Sapindus Trifoliatus Fruit Extract>YUZU Ceramide B<Citrus Junos Fruit Extract>
QD QD
IECIC2015
IECIC2015
IECIC2015
BOTANPI Liquid B<Paeonia Su�ruticosa Root Extract>
QD IECIC2015
IECIC2015
Intercellular lipid(e.g. Ceramide)Water
Natural Moisturizing Factor (NMF)
Improvement of trans epidermal water loss (TEWL) caused by surfactant with YUZU Ceramide B
Control(10% SDS treatement)
YUZU Ceramide B
QD IECIC2015
derSoapnut Extract Powder
1.35% SLES
5% Soapnut Extract Powder
Repeated washing damaged skin
Less scales after repeated washing
Soapnut Extract Powder decontaminated Staphylococcus aureus (S. aureus) which worsens atopic dermatitis.Still, Soapnut Extract Powder was con�rmed to be a cleansing agent that is less damaging to the skin (photo to the right).
0.5
0.6
0.7
0.8
0.9
1.0
Ant
ibac
teria
l e�
cacy
(r
elat
ev v
alue
) **** : p<0.05
After 1st wash(Soap base)
After 2nd wash(+1% Soapnut Ext.)
Staphylococcus aureus
** : p<0.05
** : p<0.05
■
8
10
12
14
Damaged skin After treatment
■
TEW
L (g
/m2 h)
●
●
**YUZU Ceramide B
Control
❶ Improvement of Barrier Function
Non-UV
0 20 40 60 80 100IL-1α (ng/mL)
**
**
0
20
40
60
80
100
0 0.1 0.2 0.3 0.4 0.5
GK2
❹ Inhibiting Inflammatory Mediator
6
QD Permitted to be used as quasi-drugs in Japan. QD status is depending on products, contact us for details.QD* IECIC2015 Listed in the Inventory of Existing Cosmetic Ingredient in China 2015.
Moisturizing
Ceramide
Corneocyte
NMF
Aquaporin disorder
Decrease of ceramide
Epidermal cells
Tight Junction
Tight junction disorder
Troublous ridgesand furrows
Corni�cation disorderIncrease of watertranspiration rate
Decrease of NMF
BIO-PGA series Maple Water
MandarinClear /HS
YUZU Ceramide B
LEMONGRASS Liquid B CHRONO CHARDY /G
Improvement of Water Channel ❻
Natural Water Supply❷
Improvement of TJ Barrier❺
Film Formation / Increase NMF ❸
Ceramide Trans�er❹
Improvement of Barrier Function❶
<Acer Saccharum (Sugar Maple) Sap>
<Citrus Reticulata (Tangerine) Peel Extract>
<Citrus Junos Fruit Extract>
<Vitis Vinifera (Grape) Fruit Extract> <Cymbopogon Schoenanthus Leaf/Stem Extract>
<Polyglutamic Acid / Sodium Polygamma-Glutamate>
Natural polymer from fermentation
Promoting tight junction (TJ) Anti-aging by skin clock Promoting aquaporin
Ceramide from citrus fruit Life-invigorating water from the forests of quebec
7
Tight junction (TJ)
Stratumgranulosum
Stratumspinosum
Water TJ barrier2nd barrier
1st barrier(ceramide etc.)
Skin structure and barrier function
Tight junction (TJ) forms a second skin barrier by connecting cells.
Corneocyte
Externalirritant
T J i s a m e c h a n i s m tying cells, and it �lls the gaps among the c e l l s , c o n t r o l s t h e passage of water and ions, and regulates the function of corneocyte.
0.3% MandarinClear
Tight junction (red) Nuclear (blue)
Control
TJ formation at the cell
boundaries
N u c l e u s s t a i n i n g a n d i m m u n o s t a i n i n g w e r e performed by applying M a n d a r i n C l e a r t o t h e h u m a n e p i d e r m a l keratinocytes to observe TJ formation <2nd barrier>.
Intercellular lipid (e.g. Ceramide)
Water Natural Moisturizing Factor (NMF)
** : p<0.05
I m p r o v e m e n t o f t r a n s epidermal water loss (TEWL) caused by surfactant with YUZU Ceramide B
Control(10% SDS treatement)
YUZU Ceramide B
8
10
12
14
Damaged skin After treatment
**YUZU Ceramide B
Control
TEW
L (g
/m2 h)
BIO-PGA series
Promoting NMF (PCA) production
BIO-PGA series
Water
NMF (PCA etc.)
Wrapping from outside
PCA, lactic acid and urocanic acid, well known NMF (Natural Moisturiz ing Factor) were increased by BIO-PGA series.
Producing from inside
PCA
pro
duct
ion
(%)
14Day
2840
0
60
80
100
120
140 BIO-PGA Solution H
Sodium Hyaluronate
Control0
50
100
150
200
Ratio
of A
QP3
(%)
LEMONGRASS Liquid B
0.5% 0.7%
AQP3
LEMONGRASS Liquid B upregulated the level of aquaporin 3 in the keratinocytes.
Aquaporins (AQP) are porous proteins in the cell membrane, s e l e c t i v e l y a l l o w w a t e r molecules to pass through.
Water AQP3
Cellmembrane
Maple Water can moisturize the skin and boost the skin’s barrier function at the sometime, thus treating dry skin in winter.
e�ective
90
100
110
Elec
tric
al c
apac
itanc
e (%
)
Before After (14 days)Maple Water
TEW
L (%
)
80
90
100 e�ective
Before After (14 days)Maple Water
In cltured human epidermal cells CHRONO CHARDY increased the ABCA12 <night time barrier gene> and FLG <daytime moisturizing gene> mRNA expressions.
In the human monitor test, the application of CHRONO CHARDY signi�cantly increased the water c o n t e n t a n d i m p r o v e d t h e condition of the stratum corneum.
UP
Before After (4 weeks)
100
110
120
Rela
tive
elec
tric
al c
apac
itanc
e
**
** : p<0.05 vs. Before
*** : p<0.01, ** : p<0.05 vs. Each control
n.s.
Moisturizing Effect
1% CHRONOCHARDY
Control
**
Rela
tive
gene
exp
ress
ion
0
0.5
1.0
1.5
2.0
ABCA12 FLG
UP UP***
Cont
rol
Cont
rol
0.5%
CHR
ONO
CHA
RDY
0.5%
CHR
ONO
CHA
RDY
*excluding BIO-PGA Na Powder
Natural polymer from fermentation
Promoting tight junction (TJ) Anti-aging by skin clockPromoting aquaporin
Ceramide from citrus fruit Life-invigorating water from the forests of quebec
<Polyglutamic Acid / <Acer Saccharum (Sugar Maple) Sap>
<Citrus Reticulata (Tangerine) Peel Extract>
<Citrus Junos Fruit Extract> Sodium Polygamma-Glutamate>
<Vitis Vinifera (Grape) Fruit Extract> <Cymbopogon Schoenanthus Leaf/Stem Extract>
BIO-PGA series Maple Water
MandarinClear /HS
YUZU Ceramide B
LEMONGRASS Liquid B LEMONGRASS Liquid B CHRONO CHARDY /G
Film Formation / Increase NMF Improvement of Barrier Function
Improvement of TJ Barrier
Natural Water Supply
Ceramide Trans�er Improvement of Water Channel ❻
❷
❺
❸
❹
❶ QD IECIC2015
IECIC2015
IECIC2015 QD IECIC
2015IECIC2015QD
QD*
8
QD Permitted to be used as quasi-drugs in Japan. QD status is depending on products, contact us for details.QD* IECIC2015 Listed in the Inventory of Existing Cosmetic Ingredient in China 2015.
Anti-Acne
Neutrophil
Acne
Breeding of P.acnes
In�ammationOxidation
Bacteria( P.acnes)
Comedo
Androgenic hormone elution
Sebaceous elution promotionHyperkeratosis
Delaminated keratin
Promoting turnover
Fermentage PEAR B Inhibiting P. acnes
OUBAKU Liquid B
Inhibiting COX-2
NEEM Leaf Liquid B/G
Inhibiting 5 alpha-reductase
JIOU Liquid /B
Inhibiting lipase
CUREBERRY Biobene�ty /G/HS
Minimizing Pore❻
Anti-Sebum❸
Anti-In�ammation❹
Exfoliation❺
Anti-Free Fatty Acid❷
Anti-Bacteria❶
<Phellodendron Amurense Bark Extract>
<Vaccinium Myrtillus Leaf Extract>
<Rehmannia Chinensis Root Extract>
<Melia Azadirachta Leaf Extract>
<Lactobacillus/Pear Juice Ferment Filtrate>
<Cynara Scolymus (Artichoke) Leaf Extract>
Inhibiting NF- B κ
9
N
OCH3
+
OCH3
O
O 5 alpha-Reductase
Oily Skin DHT Testosterone Acne
Turnover helps anti-acne by inhibiting hyperkeratosis. Fermentage PEAR B promotes turnover on the skin tanned by DHA.
NF-κB
Melanocyteproliferation
Spread-Open(Corn-shaped Pores)
Blackhead
Virtually perceptiblepores
Biobene�tySuppression
κB
κB
Hyperkeratosis
Suppression
Control20’s Female
Fermentage PEAR B
5% Biobenefity
Skin browning was decreased
7 days
OUBAKU Liquid
P. acnes
2 months
Phellodendron bark is the source of alkaloids such as berberine.
OUBAKU Liquid series inhibits P. acnes which causes acne.
JIOU Liquid inhibits the enzyme which converts testosterone to DHT, t h e s t r o n g e s t m a l e hormone promoting sebum production.
Bacteria such as P. acnes makes lipase, and free fatty acid is released from triglyceride by lipase. The free fatty acid is causing in�ammation at acne.
In�ammation cytokines, prostaglandins are synthesized from arachidonic acid by the action of cyclooxygenase (COX). NEEM Leaf Liquid B inhibits COX-2, and has anti-in�ammation e�ect.
Biobene�ty inhibits abnormal keratinazation, which cause lager visible pores.
C U R E B E R R Y inhibiting the enzyme lipase, as a result free f a t t y a c i d i s inhibited.
7%JIOU Liquid
1.4%JIOU Liquid
0 10 20 30 40 50 60Inhibition rate of 5α-reductase (%)
0 10 20 30 40 50 60 70 80
3.08% CUREBERRY
1.4% CUREBERRY
0.14% CUREBERRY
Inhibition of lipase activity (%)
1%NEEM Leaf Liquid B
0.1%NEEM Leaf Liquid B
0 20 40 60 80Inhibition rate (%)
COX-1COX-2
Promoting turnover
Fermentage PEAR B
Inhibiting P. acnes
OUBAKU Liquid B
Inhibiting COX-2
NEEM Leaf Liquid B/G
Inhibiting 5 alpha-reductase
JIOU Liquid /B
Inhibiting lipase
CUREBERRY Biobene�ty /G/HS Minimizing Pore❻
Anti-Sebum❸
Anti-In�ammation❹
Exfoliation❺
Anti-Free Fatty Acid❷
Anti-Bacteria❶
<Phellodendron Amurense Bark Extract>
<Vaccinium Myrtillus Leaf Extract>
<Rehmannia Chinensis Root Extract>
<Melia Azadirachta Leaf Extract>
<Lactobacillus/Pear Juice Ferment Filtrate>
<Cynara Scolymus (Artichoke) Leaf Extract> Inhibiting NF- B κ
QD IECIC2015 QD IECIC
2015 QD IECIC2015
QD IECIC2015
IECIC2015
IECIC2015QD*QD*
10
QD Permitted to be used as quasi-drugs in Japan. QD status is depending on products, contact us for details.QD* IECIC2015 Listed in the Inventory of Existing Cosmetic Ingredient in China 2015.
Hair Care / Hair Growth
Treat Split End Film formation Moisturizing
Prevent Hair Damage
Protect Cuticle
Hair growth - Hair Papilla Cell - Blood circulation
UVNormal hair
Perming
Bleaching & coloring
PermingBleaching & coloring Blow-drying Brushing
Damage of cuticle
Residual hydrogen peroxide-induced damage
Split hair
Porphyran from seaweed (NORI)
ALGAE FILMER / IPF-100K
Chlorogenic acid from co�ee
Ca�enoage
Hydroxypropyl chitosan from crab shell
HPCH series
Increasing hair papilla cell
Biocellact CHAMOMILLA BD Ceramide from japanese citrus
YUZU Ceramide B
Increasing blood circulation
JIOU Liquid /B
Hair Thickening / Hair Growth ❻
Cuticle Restore❷
Hair Thickening / Treat Split End ❹
Hair Thickening / Hair Growth ❺
Film Formation / Moisturizing ❸
Prevention of Hair Damage ❶
<Chamomilla Recutita (Matricaria) Flower Extract>
<Porphyra Yezoensis Extract> <Hydroxypropyl Chitosan> <Rehmannia Chinensis Root Extract>
<Co�ea Arabica (Co�ee) Seed Extract> <Citrus Junos Fruit Extract>
11
QD IECIC2015 QD IECIC
2015 QD IECIC2015
QD IECIC2015
IECIC2015
IECIC2015QD QD
O
OH
OH
O
OOH
OH
O
O
O
OH
O
OH
OH
CH2OH
CH2
CH2OR
CH2
OSO3-
O
R : H, CH3
Apply & Dry for 30 times / Apply & Wash o� for 30 times
1% YUZU Ceramide B BleachedCa�enoage
JIOU Control JIOU Control JIOU Control
Before Test 5 min. later 0 min. later Bleached 5% ALGAE FILMER
①
②
③
④
⑤
⑥ALGAE
FILMER
60 80 100 120Hair strength (relative value)
Control
*** : p<0.01
***
0 2 4 6 8 10 12
PVP
PVA
Sodiumhyaluronate
ALGAEFILMER Holding water UP
Hair strength UP
Retained moisture content (%)
2 months
Cell number (a.u.) *** : p<0.01
***
0.3 0.4 0.5 0.6
Control
0.14% BiocellactCHAMOMILLA B
Hair papilla cell
Control
0.002% Biocellact CHAMOMILLA B
Senescent cell less
16 passagesSuppresion of TA-stem cell aging
Many senescent cell (green)
O
O
O
O O
n
CH2OR
CH2ORNR2
OR RO
NR2
R= or
H
H
m
CH2CHO
CH3
Damaged hair by Hair dyeControl
Ca�enoage contains about 0.1% of chlorogenic acid, con�rmed anti-oxidation e�ect.
Ca�enoage prevented damage of hair cuticles.
Hair cuticles are preserved
YUZU Ceramide B restored hair cuticles.
YUZU Ceramide B contains the ceramide which is very similar to human ceramide II and V existing in stratum corneum. It is reported that 20% of human skin ceramide is type-II, and human hair are made of ceramide type-II and V.
Biocellact CHAMOMILLA BD increases number of human hair papilla cells, which expects hair growth.
Porphyran is water soluble �ber, which constitutes cell w a l l t o p r o t e c t t h e c e l l s against harsh environment.
HPCH Liquid has strong a�nity to hair.
#1, 2 and 3 10% H2O2 + 10% NH3 for 30 minutes without HPCH
#4, 5 and 6 10% H2O2 + 10% NH3 for 30 minutes with HPCH Liquid 25%
<Chamomilla Recutita (Matricaria) Flower Extract>
<Porphyra Yezoensis Extract> <Hydroxypropyl Chitosan> <Rehmannia Chinensis Root Extract>
<Co�ea Arabica (Co�ee) Seed Extract> <Citrus Junos Fruit Extract>
Porphyran from seaweed (NORI)
ALGAE FILMER / IPF-100K
Chlorogenic acid from co�ee
Ca�enoage
Hydroxypropyl chitosanfrom crab shell
HPCH series
Increasing hair papilla cell
Biocellact CHAMOMILLA BD
Ceramide from japanese citrus
YUZU Ceramide B
Increasing blood circulation
JIOU Liquid /B Hair Thickening / Hair Growth ❻
Cuticle Restore❷
Hair Thickening / Treat Split End ❹
Hair Thickening / Hair Growth ❺
Film Formation / Moisturizing ❸
Prevention of Hair Damage ❶Hair Care Hair Growth
12
Recommended ProductsCategory Product Name Main Efficacy Common Name [INCI name]
(BG = Butylene Glycol, G = Glycerin, MP = Methylparaben)JP
QDCH
IECIC 2015
SKIN
Anti-aging
Anti-wrinkle
Biocellact CHAMOMILLA BD TA-stem cell longevity Matricaria [Chamomilla Recutita (Matricaria) Flower Extract, Water, BG] JSQI Y
CUREBERRY Promote GABA in skin by GAD Bilberry [Vaccinium Myrtillus Leaf Extract, Water, BG] IPS Y
Phyto Hyaluron B Promote hyaluronic acid in skin Okra [Hibiscus Esculentus Fruit Extract, Water, BG] JSQI Y
PrincessCare /G Protect basement membrane (Anti-tryptase) Mountain Geranium [Geranium Robertianum Extract, Water, BG/G] IPS / N Y
Anti-spotsClarity
Evening toneLuminousLightening Brightening Whitening
Alpiniawhite /HS Activating melanogenic-brake signal Alpinia Katsumadai [Alpinia Katsumadai Seed Extract, Water, BG] IPS Y
Biobenefity /G/HS Decrease excess melanocytes promotion Artichoke [Cynara Scolymus (Artichoke) Leaf Extract, Water, BG/G] IPS / N Y
CinderellaCare Inhibit melanosome transportation Wild Thyme [Thymus Serpyllum Extract, Water, BG] JSQI Y
Clairju Inhibit melanosome transfer Prune [Hydrolyzed Prunus Domestica, Water, BG] JSQI Y
KIWI Liquid B Discharge stagnant melanin Kiwi [Actinidia Chinensis (Kiwi) Fruit Extract, Water, BG] JSQI Y
MandarinClear /HS Luminosity improved by good reflection Tangerine [Citrus Reticulata (Tangerine) Peel Extract, Water, BG] JSQI Y
Sensitive skin
Anti-inflammation
Soothing
Biobenefity /G/HS Inhibit NF-kB transcription Artichoke [Cynara Scolymus (Artichoke) Leaf Extract, Water, BG/G] IPS / N Y
NEEM Leaf Liquid B/G Inhibit COX-2 Neem [Melia Azadirachta Leaf Extract, Water, BG/G] IPS / N Y
SAKURA Extract B Reduce erythema / Anti-histamin Sakura [Prunus Yedoensis Leaf Extract, Water, BG] IPS Y
Moisturizing
BIO-PGA series NMF enhancement [Polyglutamic Acid, Water, BG or Alcohol and MP] (Powder available) IPS / N Y
CHRONO CHARDY /G Skin clock enhancement Common Grape [Vitis Vinifera (Grape) Fruit Extract] N Y
LEMONGRASS Liquid B Promote aquaporins Lemongrass [Cymbopogon Schoenanthus Leaf/Stem Extract, Water, BG] IPS Y
Maple Water Natural maple sap Sugar maple [Acer Saccharum (Sugar Maple) Sap] N N
YUZU Ceramide B Promote collagen and HA Yuzu [Citrus Junos Fruit Extract, Water, BG] IPS Y
UV / Sun care IZAYOI /G Prevent sunburn (Inhibit DAMPs response) Rosa Roxburghii Fruit [Rosa Roxburghii Fruit Extract, Water, BG/G] JSQI / N Y
Puffiness
Sliming
AMACHA Liquid B(N) Inhibit maturity of pro-lipocyte Hortensia [Hydrangea Serrata Leaf Extract, Water, BG] JSQI Y
CUREPASSION /G Lymphatic vessel formation Passion Fruit [Passiflora Edulis Fruit Extract, Water, BG/G] N Y
JPQD : Quasi-Drugs in Japan, JSQI : The Japanese Standards of Quasi-Drug Ingredients, IPS : Individual Permitted Specification by IchimaruIECIC2015 : Inventory of Existing Cosmetic Ingredients in China 2015, Y : Listed, N : Not listed
13
SKIN
Dark-circleCUREPASSION /G Lymphatic vessel formation Passion Fruit [Passiflora Edulis Fruit Extract, Water, BG/G] N Y
JIOU Liquid /B Improve blood circulation [Rehmannia Chinensis Root Extract, Water, BG] JSQI Y
Oily-skinFLAVOSTERON SB Inhibit sebaceous gland Soybean [Glycine Soja (Soybean) Seed Extract, Water, BG] JSQI Y
JIOU Liquid /B Inhibit 5α-reductase [Rehmannia Chinensis Root Extract, Water, BG] JSQI Y
Anti-acne OUBAKU Liquid B Anti-bacteria [Phellodendron Amurense Bark Extract, Water, BG] JSQI Y
Deodorant SHAKUYAKU Liquid B Deodorize ammonia, Trimethylamine Chinease Peony [Paeonia Albiflora Root Extract, Water, BG] JSQI Y
Cleansing Soapnut Extract Powder Foaming, Remove make up, Deodorant Three-leaf Soapberry [Sapindus Trifoliatus Fruit Extract] N Y
Anti-glycation Absorage Glycation inhibitor [Plantago Major Seed Extract, Water, BG] IPS Y
Minimizing pore Biobenefity /G/HS Inhibit NF-kB transcription Artichoke [Cynara Scolymus (Artichoke) Leaf Extract, Water, BG/G] IPS / N Y
Anti-pollution OUGON Liquid B/G Inhibit environmental toxicity pathway (AhR) Scute [Scutellaria Baicalensis Root Extract, Water, BG/G] JSQI Y
HAIR
Hair care
ALGAE FILMER / IPF-100K Hydrophilic film form [Porphyra Yezoensis Extract, Water, Alcohol and MP/BG] JSQI Y
BIO-PGA series Protect cuticle / Film form [Polyglutamic Acid, Water, BG or Alcohol and MP] (Powder available) IPS / N Y
HPCH Liquid 10 Hair thickening / Split end care [Hydroxypropyl Chitosan, Water, Alcohol] JSQI Y
YUZU Ceramide B Treat damaged hair by fruit ceramide Yuzu [Citrus Junos Fruit Extract, Water, BG] IPS Y
Hair growth
Biocellact CHAMOMILLA BD Increase hair papilla cell Matricaria [Chamomilla Recutita (Matricaria) Flower Extract, Water, BG] JSQI Y
BOTANPI Liquid B Anti-inflamation for hair growth Mountain Peony [Paeonia Suffruticosa Root Extract, Water, BG] JSQI Y
JIOU Liquid /B Inhibit 5α-reductase / Improve blood circulation [Rehmannia Chinensis Root Extract, Water, BG] JSQI Y
ECO
Sustainability NEEM Leaf Liquid B/G Inhibit COX-2 Neem [Melia Azadirachta Leaf Extract, Water, BG/G] IPS / N Y
OrganicCUCUMBER Organic Moisturizing Cucumber [Cucumis Sativus (Cucumber) Fruit Extract, Water, BG] JSQI Y
Soapnut Extract Powder Cleansing, Foaming, Deodorant Three-leaf Soapberry [Sapindus Trifoliatus Fruit Extract] N Y
Ecocert ecofarm series (see ->)ecofarm BILBERRY LEAF-E, G / CRATAEGUS-E, B / CUCUMBER-E, G / LAVENDER-E, B / ROSE HIPS-E, B / ROSEMARY-E, B / SAGE-E, B / THYME-E, B / YARROW-E, B [E = Ethanol, G = Glycerin, B = Natural BG made from sugarcane]
JSQI/ N Y
No BGPowder items (see->) Bio-PGA Na Powder / OUGON Extract Powder / Soapnut Extract Powder JSQI
/ N YGlycerin items (see->) Biobenefity G / CHRONO CHARDY G / CUREPASSION G / IZAYOI G / NEEM Leaf Liquid G / OUGON Liqiud G / PrincessCare G
Natural BG HS series (see->) Alpiniawhite HS / Biobenefity HS / Biocellact ALOE VERA B(HS) / MandarinClear HS JSQI / IPS Y
14
PRINTED 2019.02.04 EN R7
○ Head Office318-1, Asagi, Motosu-shi, Gifu 501-0475 JAPANPhone: +81 (0) 58 320-1032Fax: +81 (0) 58 320-1039e-Mail : [email protected]
○ Tokyo BranchPhone: +81 (0) 3 3663-4447 Fax: +81 (0) 3 3663-4448
Any ingredient may cause irritation such as allergies. Please exercise enough caution when using it.
○ ICHIMARU PHARCOS CHINA (Shanghai)Phone: +86 (0) 21 6125-6821
*REQUESTS CONCERNING WITH INTELLECTUAL PROPERTY RIGHTS AND OTHERSWe have the following request to make regarding the handling of the catalog of our company’s products, technological materials, samples, photographs, etc. which we have presented to you. We presented these materials on the basis of our mutual trust, and do not allow any use of these for the sake of your company’s intellectual property rights (industrial property rights such as patents, trademarks, copyrights, etc.) However, if you wish to use entries in these materials in your in-company materials, we request that you exercise final judgment on this matter based on the position of your company, giving due consideration to intellectual property rights of other companies, the Pharmaceutical Affairs Act, the Act Against Unjustifiable Premiums and Misleading Representations, etc., and extending us your kind understanding and courtesy.
○ Osaka BranchPhone: +81 (0) 6 4706-3885 Fax: +81 (0) 6 4706-3886
Personal Care Active Mapping
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