Personal Genetics

A Self-Discovery Platform

© 23andMe, Inc. 2

Personal Genetics--Why Now?

• People want to know

• Information is empowering

• Genetics research + community =

more power

• Whole genome sequencing is coming

• Education is key

© 23andMe, Inc. 3

Personal Genome Service™

• Launched Nov 2007• ~600K genotypes generated per customer• From 14 to over 100 reports

– Research Reports/Clinical Reports

• Added survey tools• Added community feature

– Over 1000 conversation threads

• Moved to second generation array• Launched research platform (23andWe)

© 23andMe, Inc. 4

v2 Custom Content

• Ancestry markers (Y and Mito coverage)

• DMET for PGx-focused studies

• Rare mutations for carrier status– BRCA, LRRK2, Cystic Fibrosis, etc.

• HLA coverage for immune system

• SNPs of interest published in recent GWAS studies

• Launched research platform (23andWe)

© 23andMe, Inc. 5

Genomic Cloud Computing

© 23andMe, Inc. 6

GenomeCanvas

© 23andMe, Inc. 7

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Mother/Child

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Identical

Half-identical

Different

Siblings

Health and Traits

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Crohn’s Disease Risk

© 23andMe, Inc. 14

Crohn’s Disease Risk

© 23andMe, Inc. 15

Crohn’s Disease(50-60% Genetics Risk)

Personal Genetics

A Research Platform

© 23andMe, Inc. 17

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23andWe Surveys

© 23andMe, Inc. 19

Parkinson’s Study

Personal Genetics

A Translational Platform

© 23andMe, Inc. 21

New: Warfarin PGx Report

Goal: Build large community of patients on warfarin, track INRs, develop evidence base for genetic data, find additional markers.

© 23andMe, Inc. 22

PGS™ PHR

Research Data

EMR

Healthcare Consumer

Clinicians Hospitals

ValidatedData

Testing Labs

Patient-Centric Health Data