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Curriculum vitae

PERSONAL INFORMATION Berend Wilffert

WORK EXPERIENCE

1984–1986 Head of the laboratory in the Respiration Therapeutics DepartmentDr. Karl Thomae GmbH in Biberach an der (Germany)

1986–1989 Coordinator Cardiovascular PharmacologyJanssen Research Foundation in Neuss (Rosellen) (Germany)

1989–1991 Director Cardiovascular PharmacologyJanssen Research Foundation in Neuss (Rosellen) (Germany)

1991–1993 Director of the Institute for Experimental MedicineJanssen Research Foundation in Neuss (Rosellen) (Germany)

1993–1996 Manager of the Department of Pharmacological-Toxicological ResearchGrünenthal GmbH, Stolberg (Germany)

1996–1996 Project Manager New Analgetics Grünenthal GmbH, Stolberg (Germany)

1996–1997 Director Scientific AffairsPharma Bio-Research International B.V. in Zuidlaren (Netherlands)

1998–1999 Director Scientific Affairs and Quality AssurancePharma Bio-Research International B.V. in Zuidlaren (Netherlands)

1999–2000 Head Clinical PharmacyZorggroep Noorderbreedte Leeuwarden (Netherlands)

2000–2001 Member of the Institutional Review Board (Toetsingscommissie Patiëntgebonden Onderzoek) Medical Center Leeuwarden (Netherlands)

2001–2009 Deputy chairman and clinical pharmacologist (from 2004 onwards) Regional Review Board (Regionale Toetsingscommissie Patiëntgebonden Onderzoek) (Netherlands)

2001–2009 visiting senior researcherDepartment of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy of the Rijksuniversiteit Groningen (Netherlands)

2001–2007 Head Clinical Pharmacy

8/3/17 © European Union, 2002-2017 | http://europass.cedefop.europa.eu / 50

Curriculum vitae Berend Wilffert

Zorggroep Noorderbreedte and Hospital De Tjongerschans, Leeuwarden/Heerenveen (Netherlands)

2008–2009 Clinical PharmacistZorggroep Noorderbreedte and Hospital De Tjongerschans, Leeuwarden/Heerenveen (Netherlands)

2009–2011 Chairman and clinical pharmacologistRegional Review Board (Regionale Toetsingscommissie Patiëntgebonden Onderzoek) (Netherlands)

2009–2011 DocentDepartment of Pharmacotherapy & Pharmaceutical Care (0,2fte) and at the Department of PharmacoEpidemiology & PharmacoEconomics (0,2fte) of the Rijksuniversiteit Groningen (Netherlands)

2009–2011 PharmacistDepartment of Quality and Patient Safety at the Zorggroep Noorderbreedte, Leeuwarden (0,6 fte) (Netherlands)

2011–Present ProfessorPharmacotherapy & Clinical Pharmacy, Head of the Section Pharmacotherapy & Pharmaceutical Care at the University of Groningen and the University Medical Centre Groningen (Netherlands)

2012–Present Deputy chairman/clinical pharmacologistfrom the BEBO (Assen) and chairman from Room A (Netherlands)

2012–Present Deputy clinical pharmacologistRegional Review Board (Regionale Toetsingscommissie Patiëntgebonden Onderzoek) (Netherlands)

2012–Present Lehrauftrag Klinische Dokumentation at the Studiengang Drug Regulatory AffairsRheinische Friedrich-Wilhelms-Universität Bonn (Germany)

2014–Present JurorGalenus Awards (Netherlands)

2014–Present BoardmemberNVMETC (Nederlandse Vereniging Medisch Ethische Toetsings Commissies) (Netherlands)

2014–Present MemberEthics Panel of the European Patients’ Academy on Therapeutic Innovation (EUPATI) (Netherlands)

2017–Present Clinical pharmacologistMedical Ethics Committee of the UMCG (Netherlands)

EDUCATION AND TRAINING



1973–1976 B.Sc. degree in Pharmacy (with credit)

1976–1978 M.Sc. degree in Pharmacy (with credit) Subsidiary subject: Pharmacology (ganglionic muscarine receptors)

1978–1978 KNMP award (Royal Dutch Society for the Advancement of Pharmacy)

1980–1980 Pharmacist’s exam (state exam)

1980–1984 taking Ph.D. (Dr. rer. nat.) (with credit)

1986–1986 registration as experimental pharmacologist in the Netherlands (registration number 86-005)

1993–1993 qualification for teaching Pharmacology at the Johann Wolfgang Goethe University in Frankfurt am Main, Germany (Habilitation/ Privatdozent)

1999–1999 teaching activities in Pharmacology changed to the Rheinische Friedrich-Wilhelms-Universität Bonn, Germany (Umhabilitation)

2004–2004 recognition by the CCMO as clinical pharmacologist as meant by the Wet Medisch- Wetenschappelijk Onderzoek met Mensen (WMO)

2008–2008 registration as clinical pharmacologist in the Netherlands

2012–2012 BROK examination

ADDITIONAL INFORMATION

Expertise

Publications LECTURES AND POSTERS

B. Wilffert, P.B.M.W.M. Timmermans, P.A. van Zwieten:

Lokalisatie van - en -adrenerge receptoren.

Farmacologie-dag (Ned. Ver. Farmacol.), Utrecht, December 9, 1980

B. Wilffert, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Karakterisering van -adrenerge receptoren. II. Antagonisten.

Vrije Mededelingendag Sectie Farmacochemie der K.N.C.V., Weesp, December 19, 1980

B. Wilffert:

Localization of - and -adrenoceptors.

22. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz,

March 10-13, 1981


De intra- en extrasynaptische lokalisatie van postsynaptische 1-, 2-, 1- en 2-receptoren in



nicotinerge en muscarinerge banen.

Farmacologie-dag (Ned. Ver. Farmacol.), Utrecht, November 17, 1981


Evidence for an extrasynaptic location of 2- and 2-adrenoceptors.

22nd Dutch Federative Meeting, Utrecht, April 22-24, 1981

A. de Jonge, B. Wilffert, H.O. Kalkman, M.J.M.C. Thoolen, J.C.A. van Meel,

P.B.M.W.M. Timmermans and P.A. van Zwieten:

Effect of captopril on the regulation of noradrenaline release in the heart and vascular smooth muscle of the pithed rat.

Meeting of the British Pharmacological Society, London, December 16-18, 1981

J.C.A. van Meel, B. Wilffert, H.O. Kalkman, M.J.M.C. Thoolen, A. de Jonge,


2-Adrenergic pressor responses and corticosteroids in the pithed rat.


P.B.M.W.M. Timmermans, B. Wilffert, H.O. Kalkman, M.J.M.C. Thoolen, J.C.A. van Meel, A. de Jonge and P.A. van Zwieten:

Selective inhibition of 2-adrenoceptor-mediated vasoconstriction in vivo by captopril

and MK-421.


P.B.M.W.M. Timmermans, B. Wilffert and P.A. van Zwieten:

Extrasynaptic location of vascular 2- and 2-adrenoceptors in the normotensive rat.


P.A. van Zwieten, J.C.A. van Meel, A. de Jonge, B. Wilffert and P.B.M.W.M. Timmermans:

Central and peripheral -adrenoceptors.

Symposium: Alpha-adrenoceptors in cardiovascular regulation.

Satellite Workshop of the 8th Scientific Meeting of the International Society of Hypertension, Basel, June, 1981

B. Wilffert, M.A.M. Gouw and P.B.M.W.M. Timmermans:

Innervation of vascular - and -adrenoceptors in the normotensive rat.

23. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz,

March 16-19, 1982

K. de Zoeten, J.C.A. van Meel, B. Wilffert, M.J. Mathy, P.B.M.W.M. Timmermans and

P.A. van Zwieten:

Quantification of the inhibitory action of calcium antagonists towards 2-adrenoceptor-mediated pressor responses in vivo.

23rd Dutch Federative Meeting, Amsterdam, April 7-8, 1982

M.A.M. Gouw, B. Wilffert, P.B.M.W.M. Timmermans and P.A. van Zwieten:

A model for the study of vascular 2-adrenoceptors in vivo.


A. de Jonge, B. Wilffert, J.C.A. van Meel, H.O. Kalkman, P.B.M.W.M. Timmermans and

P.A. van Zwieten:

The effect of inhibition of the renin-angiotensin system on the release of noradrenaline in

the heart and blood vessels of the normotensive rat.


J.C.A. van Meel, A. de Jonge, B. Wilffert, H.O. Kalkman, P.B.M.W.M. Timmermans and

P.A. van Zwieten:

The influence of corticosteroids on 2-adrenoceptor pressor responses in adrenalectomized rats.




P.B.M.W.M. Timmermans, M.J. Mathy, H.O. Kalkman, B. Wilffert, P.A. van Zwieten,

D. Dijkstra and A.S. Horn:

Cardiovascular properties and in vivo 1/ 2-selectivity of mono- and dihydroxy-2-amino-tetralins.


B. Wilffert, M.A.M. Gouw, P.B.M.W.M. Timmermans and P.A. van Zwieten:

The intra- and extrasynaptic localization of vascular 1-, 2- and 2-adrenoceptors.


B. Wilffert, M.A.M. Gouw, A. de Jonge, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Interaction between 1/ 2-adrenergic and 2-adrenergic effects.

Pharmacological Meeting (Dutch Soc. Pharmacol.), Utrecht, November 16, 1982

B. Wilffert:

1/ 2-Adrenoceptor localization.

Meeting der Deutschen Pharmakologischen Gesellschaft, Bad Neuheim, June 25-26, 1982

D. Davidesko, P.B.M.W.M. Timmermans, B. Wilffert and P.A. van Zwieten:

-Adrenoceptor-mediated vasoconstriction in the pithed rat induced by stimulation of subclasses of ganglionic muscarinic receptors.

Meeting of the British Pharmacological Society, London, January 5-7, 1983

B. Wilffert:

The interference between 1- and 2-adrenoceptor-mediated vascular effects in the pithed normotensive rat. Indications for two populations of 1-adrenoceptors.

Joint Spring Meeting Deutsche Pharmakologische Gesellschaft, Deutsche Physiologische Gesellschaft, Mainz, March 14-18, 1983

M.A.M. Gouw, A. de Jonge, P.B.M.W.M. Timmermans, M.J.M.C. Thoolen, B. Wilffert and P.A. van Zwieten:

Indications for different locations of 2-adrenoceptors in the rat demonstrated by

2-adrenoceptor mediated vasodilatation.

Meeting of the British Pharmacological Society, Leicester, July 6-8, 1983

J.J. Beckeringh, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans, B. Wilffert and P.A. van Zwieten:

Differential effect of D 600 on contractions of rat and guinea-pig aorta by different

1-adrenoceptor agonists.



1-Adrenoceptor agonism of cirazoline and St 587 on rat isolated aorta.


A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans, B. Wilffert and P.A. van Zwieten:

Effect of captopril and nifedipine on the noradrenaline-induced vasoconstriction in cats.


A. de Jonge, M.J. Mathy, P.B.M.W.M. Timmermans, M.J.M.C. Thoolen, B. Wilffert and

P.A. van Zwieten:

1-Adrenoceptor subtypes in vascular smooth muscle of the pithed rat; discrimination by calcium-entry blockade.


B. Wilffert, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Further subclassification of vascular 2-adrenoceptors.

Joint Meeting of the French and German Pharmacological and Toxicological Societies, Freiburg i.Br., September 19-22, 1983

D. Davidesko, B. Wilffert, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and



P.A. van Zwieten:

Role of ganglionic M-1 and M-2 receptors in the innervation of the cardiovascular system of the normotensive rat studied with pilocarpine.


A. de Jonge, M.J. Mathy, B. Wilffert, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and

P.A. van Zwieten:

Influence of acid-base balance on vasoconstriction mediated by 1- and 2-adrenoceptor stimulation in pithed normotensive rats.


M.J.M.C. Thoolen, J.J. Beckeringh, B. Wilffert, A. de Jonge, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Calcium entry blockade and 1-adrenoceptor mediated contractions of rat and guinea-pig isolated aortas.


P.B.M.W.M. Timmermans, M.J. Mathy, C. Korstanje, M.J.M.C. Thoolen, B. Wilffert,

A. de Jonge and P.A. van Zwieten:

Phenoxybenzamine identifies calcium influx dependent and independent mechanisms of vasoconstriction in vivo to cirazoline.


C. Korstanje, M.J.M.C. Thoolen, B. Wilffert, A. de Jonge, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Absence of antagonist selectivity for 1-adrenoceptors mediating calcium dependent and independent vasoconstriction in vivo.


F.A.M. Jonkman, M.J.M.C. Thoolen, B. Wilffert, A. de Jonge, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Effects of PTH and vitamin D3 on plasma calcium level, blood pressure and sensitivity to calcium entry blockade in rats.


J.J. Beckeringh, M.J.M.C. Thoolen, A. de Jonge, B. Wilffert, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Characterization of -adrenoceptor populations on rat and guinea-pig isolated aortas.



Interference between 1- and 2-adrenoceptor-mediated vascular effects in the pithed normotensive rat; indications for two distinct populations of vascular postjunctional

1-adrenoceptors.

24th Dutch Federative Meeting, Leiden, April 7-8, 1983

M.A.M. Gouw, B. Wilffert, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Interference between 2- and 2-adrenoceptor-mediated vascular effects in the pithed normotensive rat; indications for two populations of 2-adrenoceptors.


D. Davidesko, B. Wilffert, P.B.M.W.M. Timmermans and P.A. van Zwieten:

In sympathetic ganglia of the pithed normotensive rat M1- and M2-receptors differentially trigger -adrenoceptor-mediated vasoconstriction.




J.C.A. van Meel, J. Qian, B. Wilffert, A. de Jonge, P.B.M.W.M. Timmermans and

P.A. van Zwieten:

Hormonal modulation of 2-adrenoceptor-mediated vasoconstriction in pithed normotensive rats.


G. Smit, B. Wilffert, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Inhibitory effects of N,N-dipropyldopamine and 2-N,N-dipropylamino-6,7-dihydroxytetralin on stimulation-evoked pressor and tachycardic responses in the pithed normotensive rat.


Y.M. Harms, B. Wilffert, G. Prop, E. Graf, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Cardiovascular properties and 1/ 2-adrenoceptor activities of (±)-, (+)- and --lofexidine.



Indications for two populations of vascular 2-adrenoceptors.

Dutch Pharmacological Society, Utrecht 1983

F.A.M. Jonkman, M.J.M.C. Thoolen, A. de Jonge, B. Wilffert, P.B.M.W.M. Timmermans and P.A. van Zwieten:

The effect of salbutamol on the clonidine withdrawal tachycardia in rats.



Antagonists do not discriminate between Ca2+-influx dependent and independent mechanisms of 1-adrenoceptor-mediated vasoconstriction in pithed rats.



Differential effects of the calcium entry blocker D 600 on contractions of rat and guinea-pig aorta elicited by various 1-adrenoceptor agonists.


G. van de Berg, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans, B. Wilffert and P.A. van Zwieten:

Postjunctional 1-adrenoceptor-mediated modulation of cardiac sympathetic neurotransmission in rats.

25th Dutch Federative Meeting, 17-19 April 1984


Characterization of -adrenoceptors and the contractile mechanisms in rat and guinea-pig aortas.

25th Dutch Federative Meeting, Rotterdam 1984

K. van Charldorp, F.A.M. Jonkman, M.J.M.C. Thoolen, A. de Jonge, B. Wilffert,


Effects of urapidil on blood pressure in various animal models.



Postjunctional 1-adrenoceptor-mediated modulation of cardiac sympathetic neurotransmission in rats.

British Pharmacol. Society, London 1984

A. de Jonge, M.J. Mathy, P.B.M.W.M. Timmermans, M.J.M.C. Thoolen, B. Wilffert and

P.A. van Zwieten:

Inhibition of vasoconstriction to cirazoline in pithed rats by nifedipine after phenoxybenzamine.




K. van Charldorp, A. de Jonge, M.J.M.C. Thoolen, B. Wilffert and P.A. van Zwieten:

Selectivity of different muscarinic agonists for receptors in the heart, urinary bladder and sympathetic ganglia in the pithed rat.


D. Davidesko, B. Wilffert, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Heterogeneity of the interaction between 2-adrenoceptor agonists with the 2-adreno¬ceptor in the vascular system of the pithed rat.


H.N. Doods, H.O. Kalkman, A. de Jonge, B. Wilffert, M.J.M.C. Thoolen,


Preference of RU 24969 and pindolol for the purported 5HT1B binding site. Correlation between 5HT1A affinity and hypotensive activity.

Dutch Pharmacol. Meeting, Nijmegen, September 1984

H.N. Doods, M.J. Mathy, M.J.M.C. Thoolen, A. de Jonge, B. Wilffert,


(-)-Amidephrine, a novel selective agonist of vascular 1-adrenoceptors.


P.N.M. van Heiningen, B. Wilffert, A. de Jonge, M.J.M.C. Thoolen,


The putative calcium entry promotor Bay K 8644 differentiates between 1- and 2-adreno¬ceptor- mediated pressor responses in pithed rats.



P.A. van Zwieten:



A. de Jonge, G. Smit, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans, B. Wilffert and

P.A. van Zwieten:

Inhibitory dopamine receptors and 2-adrenoceptors on sympathetic neurons innervating the cardiovascular system of the rat.


F.A.M. Jonkman, M.J.M.C. Thoolen, B. Wilffert, A. de Jonge, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Effect of chronic hypercalcaemia on blood pressure and sensitivity to calcium entry blockade in rats.


C. Korstanje, H.N. Doods, A. de Jonge, M.J.M.C. Thoolen, B. Wilffert,


Blocking selectivity of Wy 26703 for central and peripheral pre- and postsynaptic 1- and 2- adrenoceptors.


P.W. Man, F.A.M. Jonkman, M.J.M.C. Thoolen, B. Wilffert, A. de Jonge,


Attenuation of the clonidine withdrawal syndrome by salbutamol and RA 642.


M.J. Mathy, M.J.M.C. Thoolen, A. de Jonge, B. Wilffert, P.B.M.W.M. Timmermans and

P.A. van Zwieten:



Vasoconstriction to all currently available selective 2-adrenoceptor agonists is invariably susceptible to inhibition by nifedipine.


K. van der Ploeg, J.J. Beckeringh, M.J.M.C. Thoolen, B. Wilffert, A. de Jonge,


Effect of irreversible -adrenoceptor antagonsits on the susceptibility to inhibition by calcium entry blockade of -adrenoceptor-mediated contractions of rat and guinea-pig aorta's.


R. Sprenkels, C. Korstanje, M.J.C. Thoolen, B. Wilffert, A. de Jonge,


Ca++-influx dependent and independent 1-adrenoceptor-mediated processes of vasoconstriction invivo do not operate via different 1-adrenoceptor subtypes.


G. Smit, H.N. Doods, B. Wilffert, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Different structure-activity relationship in clonidine- and guanabenz-related -adrenoceptor agonists.


M.J.M.C. Thoolen, J.J. Beckeringh, B. Wilffert, A. de Jonge, P.B.M.W.M. Timmermans and P.A. van Zwieten:

1-Adrenoceptor agonism of B-HT 920 and UK 14-304 in rat and guinea-pig aortas.


P.B.M.W.M. Timmermans, M.J. Mathy, M.J.M.C. Thoolen, B. Wilffert, A. de Jonge and

P. A. van Zwieten:

Action of phenoxybezamine on the inhibition by nifedipine of -adrenoceptor-induced vasoconstriction.


E. Vila, M.J.M.C. Thoolen, A. de Jonge, B. Wilffert, P.B.M.W.M. Timmermans and

P.A. van Zwieten:

Effect of calcium entry blockade on -adrenoceptor-mediated and K+-induced contractions of the rat isolated anococcygeus muscle.



Effect of calcium entry blockade on 1-adrenoceptor-mediated increases in diastolic pressure elicitedby catecholamines in the pithed normotensive rat.


B. Wilffert:

Adrenoceptor in the heart.

Symposium: Physiological receptor antagonism. Basel 1984

P.A. van Zwieten, M.J. Mathy, M.J.M.C. Thoolen, B. Wilffert, A. de Jonge and

P.B.M.W.M. Timmermans:

Effects of urapidil on blood pressure and adrenoceptors in various animal models.

10th Sci. Meeting Int. Soc. of Hypertension, Interlaken, June 1984

P.B.M.W.M. Timmermans, M.J.M.C. Thoolen, M.J. Mathy, A. de Jonge, B. Wilffert and

P.A. van Zwieten:

Effect of irreversible adrenoceptor antagonists on the sensitivity to inhibition by nifedipine of 1 and 2 adrenoceptor mediated vasoconstriction in pithed rats.

Dutch Pharmacol. Meeting, Nijmegen, September 1984

B. Wilffert:

Adrenoceptors in the heart.



Symposium: Receptors in the cardiovascular system.

Oss, May 31, 1985

A. de Jonge, J.C.A. van Meel, B. Wilffert, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Adrenoceptors in the cardiovascular system.

Symposium: Receptors in the cardiovascular system. Oss, May 31, 1985

H.W.G.M. Boddeke, J.B. Heynis, R. Veldsema Currie, B. Wilffert and P.A. van Zwieten:

Anti ischaemic properties of R 58735 in isolated heart preparations.

Meeting of the British Pharmacological Society, London, December 17 19, 1986.

H.W.G.M. Boddeke, J.B. Heynis, B. Wilffert and P.A. Zwieten:

A study on the mechanisms of negative inotropy of some calcium entry blockers in isolated guinea pig hearts.

Meeting of the British Pharmacological Society, London, December 17 19, 1986

B. Wilffert, D. Wermelskirchen, D. Wilhelm, B.L. Pegram, J. Hunter, U. Nebel and T. Peters:

Measurement of intracellular calcium in rat aorta without lanthanum or ethyleneglycol bis ( aminoethyl ether) N,N,N',N' tetra acetic acid (EGTA).

International Symposium on Calcium Antagonists, New York, February 10 13, 1987

D. Wilhelm, B. Wilffert, D. Wermelskirchen, B. L. Pegram, J. Hunter, U. Nebel and T. Peters:

An alternative method for the measurement of 45Ca influx in rat aorta.

28th Spring Meeting of the Deutsche Gesellschaft für Pharmakologie und Toxikologie, Mainz, March 10 13, 1987

T. Peters, M. Höller, F. Tegtmeier and B. Wilffert:

Alteration of calcium homeostasis in brain tissue upon oxygen shortage.

5th European Workshop on Clinical Neuropharmacology, Bratislava, July 6 8, 1987

B.L. Pegram, D. Wilhelm, B. Wilffert, D. Wermelskirchen, J. M. Hunter, U. Nebel and

T. Peters:

Measurement of intracellular calcium in rat aorta.

Xth International Congress of Pharmacology, Sydney, August 23 28, 1987

M.A.M. Gouw, B. Wilffert and P.A. van Zwieten:

A comparitive study of calcium channels in jugular vein and aorta of the rat. Farmacologie dag (Ned. Ver. Farmacol.), Utrecht, November 11, 1987

H.W.G.M. Boddeke, B. Wilffert, T.J.W. Jap and J.G. Hugtenburg:

Differential anti ischaemic effects of nifedipine and R 58735 in the guinea pig heart lung preparation.

Meeting of the British Pharmacological Society, London, January 6 8, 1988

P. Koch, D. Wilhelm, D. Wermelskirchen, B.L. Pegram, J. Hunter, U. Nebel, B. Wilffert and T. Peters:

A comparison of the effect of R 56865 on K+ induced contraction and increase in slowly exchanging 45Ca in the rat aorta.


P. Koch, D. Wilhelm, D. Wermelskirchen, U. Nebel, B. Wilffert and T. Peters:

The antagonistic effect of R 56865 on 1 adrenoceptor mediated contraction in isolated rat and guinea pig aorta.


J. Schneider, E. Beck, B. Wilffert and T. Peters:

A dose dependent inhibition of digitalis induced toxicity by R 56865 in the guinea pig heart lung preparation.


C. Heers, E. Scheufler, D. Wilhelm, D. Wermelskirchen, B. Wilffert and T. Peters:

The antiarrhytmic effects of R 56865 in cardiac glycoside toxicity are not caused by inhibition of receptor binding.




B. Wilffert, D. Wermelskirchen and U. Nebel:

Comparison between the effects of calcium entry blockers and R 56865 on K induced contraction andincrease in slowly exchanging 45Ca in isolated rat aorta.

29. Frühjahrstagung der Deutschen Gesellschaft für Pharmakologie und Toxikologie, Mainz, March 8 11, 1988

B. Wilffert and T. Peters:

Searching for new antiischemic compounds: Theoretical and practical aspects.

From neuron to action. International Symposium in honour of the 60th birthday of

H.H. Kornhuber, Wien, April 24 27, 1988

B. Wilffert, D. Wermelskirchen, P. Koch, D. Wilhelm and T. Peters:

A comparison between contraction and increase in slowly exchanging 45Ca in the isolated rat aorta.

11th International Subcellular Methodology Forum. Study of cellular roles of calcium, Guildford, September 6 9, 1988

E. Scheufler, R. Vogelgesang, B. Wilffert, B.L. Pegram, J. Hunter, D. Wermelskirchen and

T. Peters:

Uptake of catamphiphilic drugs into erythrocytes and muscular tissue correlates to 45Ca displacementfrom phosphatidyl serine monolayers.

Herbsttagung der Deutschen Gesellschaft für Pharmakologie und Toxikologie,

Hamburg, September 19 22, 1988

P. Koch, D. Wilhelm, B. Wilffert and T. Peters:

The antagonistic effects of R 56865 and derivatives on the NA induced contraction in the isolated rat aorta.


Hamburg, September 19 22, 1988

J. Schneider, C. Fruh, B. Wilffert and T. Peters:

adrenoceptor blocking properties of dl nebivolol and its enantiomers in the pithed rat.

Cardiovascular disease and adrenoceptor function (International Symposium), Antwerpen, October8, 1988


A search for peripheral antihypertensive properties of nebivolol additional to

1 adrenoceptor blockade in the pithed rat.

Cardiovascular disease and adrenoceptor function (International Symposium), Antwerpen, October8, 1988

J.M. Hunter, B. Wilffert and B.L. Pegram:

Neuropeptide Y (NPY) potentiation of alpha-adrenergic responses in pithed rats. APS/ASPET Meeting, Montreal, October 10 14, 1988


Discrepancies between agonist induced responses after Ca2+ entry blockade and under Ca2+ free conditions in a rat vein and artery.

Winter meeting of the British Pharmacological Society, London, December 19 22, 1988

D. Wermelskirchen, B. Wilffert, U. Nebel, A. Leidig and T. Peters:

Efects of R 56865 and R 70608 on the veratridine induced 45Ca uptake in rat aortic strips.

Winter meeting of the British Pharmacological Society, London, December 19 22, 1988

P. Koch, J. Schneider, C. Fruh, D. Wilhelm, B. Wilffert and T. Peters:

The adrenoceptor antagonist properties of R 56865 in the pithed rat.

Winter meeting of the British Pharmacological Society, London, December, 9 22, 1988


Calcium entry blockers underestimate the Ca2+ influx component of agonist induced contractions in the jugular vein and aorta of the rat.

Pharmacological meeting organized by the Dutch Society of Pharmacology,



Utrecht, November 9, 1988


Differences between four calcium entry blockers on serotonin but not KCl induced contractions of the jugular vein of the rat.

Dutch Federative Meeting, Utrecht, April 1988


Calcium entry blockade in rat vascular preparations.

Joint Meeting of the Association Francaise des Pharmacologistes and Nederlandse Vereniging voor Farmacologie, Paris, March 2 and 3, 1989

P. Koch and B. Wilffert:

An approach to differentiate among noradrenaline elicited contractile processes by means

of Ca2+ entry blockers, H 7 and ryanodine.

Spring Meeting of the Deutsche Gesellschaft für Pharmakologie und Toxikologie,

Mainz, March 14 17, 1989

D. Wermelskirchen, B. Wilffert, U. Nebel, A. Leidig and T. Peters:

Incomplete inhibition of noradrenaline induced 45Ca uptake by various organic calcium

entry blockers in rat aortic strips.

4th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research, Florence(Italy), May 25 27, 1989


Absence of blocking properties of flunarizine with respect to cardiac, vascular and peripheral neuronal Ca channels in the pithed rat.

4th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research, Florence(Italy), May 25 27, 1989

D. Wilhelm, B. Wilffert and T. Peters:

Cardiac glycoside intoxication: A model for the search of anti ischemic drugs?

Symposium organized by the Dutch Pharmacological Society: Drug treatment of cardiac ischemia, Oss, September 22, 1989

J.G. Hugtenburg, K. Belsner, A. Mozes, E. Scheufler and B. Wilffert:

Effect of nifedipine, mioflazine and dipyridamole on interstitial adenine nucleotide catabolites during global ischaemia in guinea pig hearts.


M.A.M. Gouw, B. Wilffert, D. Wermelskirchen and P.A. van Zwieten:

Noradrenaline induced Ca2+ influx in the isolated guinea pig aorta.


J. Schneider, C. Fruh, and B. Wilffert:

Nebivolol does not interact with the purinergic neurotransmission in pithed normotensive rats.

31. Frühjahrstagung der Deutschen Gesellschaft für Pharmakologie und Toxikologie,

March 13 16, 1990

D. Wermelskirchen, B. Wilffert, U. Nebel, A. Wirth, A. Leidig and T. Peters:

Effects of R 56865 and R 59494 on veratridine induced 45Ca movements in rat isolated aortae and left atria.

XIth International Congress in Pharmacology, Amsterdam, July 1 6, 1990

D. Wilhelm, E. Velten, A. Leidig, B. Wilffert and T. Peters:

Diltiazem discriminates between different stimuli of calcium entry.

XIth International Congress in Pharmacology, Amsterdam, July 1 6, 1990


Adrenoceptor blocking properties of dl nebivolol and its enantiomers in the pithed normotensive rat.

First International Nebivolol Investigators' Meeting, Antwerpen, September 13 16, 1990



D. Wilhelm, A. Leidig, C. Meuter, B. Wilffert and T. Peters:

Cardiac in vitro pharmacology of the positive inotropic compound R 80122.

XIIth Congress of the European Society of Cardiology, Stockholm, September 16 20, 1990

D. Wermelskirchen, J. Urenjak, B. Wilffert and F. Tegtmeier:

Detection of Na+ and Ca2+ movements by co measuring O2 consumption and 45Ca2+ uptake in rat cortical synaptosomes.

12th International Subcellular Methodology Forum. Cell Signalling: Experimental Strategies, Guildford,September 4 7, 1990

H.R. Schwietert, D. Wilhelm, B. Wilffert and P.A. van Zwieten:

The role of 1 adrenoceptor subtypes in the phasic and tonic responses to phenylephrine

in the longitudinal smooth muscle of the rat portal vein.

Farmacologiedag, Utrecht, December 12, 1990


The phasic and tonic responses to phenylephrine may reflect a divergence in the excitation contraction coupling of 1 adrenoceptors in rat portal vein.

Meeting of the British Pharmacological Society, London, 17 19 December, 1990

E. Scheufler, J. Hugtenburg, K. Belsner, A. Mozes, M. Pfeifer, B. Wilffert and T. Peters:

Effect of dipyridamole and nifedipine on cellular and interstitial adenine nucleotide catabolites in ischaemic guinea pig hearts.


D. Wermelskirchen, J. Urenjak, A. Beile, S. Khan, U. Nebel, A. Wirth, B. Wilffert,

F. Tegtmeier and T. Peters:

Flunarizine and R 56865 suppress veratridine induced increase in O2 consumption

and 45Ca uptake in rat cortical synaptosomes.


M. Henrichs, E. Scheufler, B. Wilffert and T. Peters:

The influence of verapamil on the extracellular potassium concentrations of the guinea pig heart underischaemic conditions.


B. Wilffert, H.R. Schwietert, M. J. Mathy, M. Pfaffendorf, D. Wilhelm and P.A. van Zwieten:

In the pithed rat, Ca2+ influx dependent and independent 1 adrenoceptor mediated

pressor responses are not mediated by 1a and 1b adrenoceptors, respectively.


B. Wilffert:

In pressor responses in pithed rats 1 adrenoceptor mediated Ca influx and Ca release

from intracellular stores are not initiated by 1a and 1b adrenoceptors.

32nd Spring Meeting of the Deutsche Gesellschaft für Pharmakologie und Toxikologie, Mainz, 12 15 March, 1991

H.R. Schwietert, M.A.M. Gouw, D. Wilhelm, B. Wilffert and P.A. van Zwieten:

The ability of some adrenoceptor antagonists to enhance the spontaneous myogenic activity in the rat portal vein shows no correlation with their adrenoceptor blocking properties.

Third International Symposium on Resistance Arteries, Rebild, Skorping, Denmark,

21-25 May, 1991

U. Vollmer, B. Wilffert and T. Peters:

An improved in vivo perfusion model for studies on transdermal drug absorption in rats.

18th International Symposium on Controlled Release of Bioactive Materials,

Amsterdam, July 8 12, 1991

E. Scheufler, I. Guttmann, A. Mozes, B. Wilffert and T. Peters:

R 56865 given only during reperfusion inhibits postischemic fibrillations:



Schedule of drug dosage.

The XIIth European Section Meeting of the ISHR, Leuven, 10-13 September, 1991

J. Schneider, E. Beck, D. de Chaffoy de Courcelles, C. Heers, B. Wilffert and T. Peters:

Cardiac effects of the highly selective phosphodiesterase-type III (PDE III) inhibitor R 80122 in an acute heart failure model.

The XIIth European Section Meeting of the ISHR, Leuven, 10-13 September, 1991

D. Wermelskirchen, B. Wilffert, U. Nebel, A. Wirth and T. Peters:

R 59494 inhibits veratridine-induced 45Ca2+ uptake in isolated rat atria in a stereospecific manner.

International Symposium on Hypoxia, Berlin, September 19-21, 1991

E. Scheufler, A. Mozes, B. Wilffert and T. Peters:

Inhibition of postischemic fibrillations by R 59494 and its optical isomers in Langendorff hearts from guinea-pigs.

The 2nd International Symposium on Hypoxia, 19-21 September, 1991


Can an interaction with glibenclamide-sensitive K+-channels be associated with the contractile effect of some -adrenoceptor antagonists in the rat portal vein?

Meeting of the Dutch Society of Pharmacology, Utrecht, 6 November, 1991

U. Vollmer, B. Wilffert, T. Peters:

An improved model for studies on transdermal drug absorption in vivo in rats.

Second International Symposium on Dermal and Transdermal Delivery New Insights and Perspectives, November 11-13, Bad Homburg, 1991


The contractile effect of some -adrenoceptor antagonists in the rat portal vein and the putative involvement of ATP-sensitive K+ channels.

Winter Meeting of the British Pharmacological Society, London, 17-19 December, 1991


Veratridine induced [45Ca2+] uptake as an indication of electrically silent Na+ channels in isolated rat aorta.

Winter Meeting of the Britih Pharmacological Society, London, 17-19 December, 1991

D. Wilhelm, M. Ebbert, A. Leidig, B. Wilffert and T. Peters:

The phosphodiesterase IV inhibitor rolipram enhances mechanical and electrical effects of the phosphodiesterase III inhibitor R 80122.

Winter Meeting of the Britih Pharmacological Society, London, 17-19 December, 1991

D. Scheller, J, Kolb, F. Tegtmeier and B. Wilffert:

Chronic flunarizine pretreatment improves lactate recovery after cortical spreading depression.

4th International Symposium on Pharmacology of Cerebral Ischemia, Marburg,

20-22 July, 1992

J. Gleitz, A. Beile, A. Khan, F. Tegtmeier and B. Wilffert:

R 56865 prevents Na+ load induced inhibition of anaerobic glycolysis in synaptosomes.

4th International Symposium on Pharmacology of Cerebral Ischemia, Marburg,

20-22 July, 1992

B. Wilffert:

A new pharmacological approach to protection of the myocardium against ischaemia.

Third International Congress: Prospects and Strategies in Cardiovascular Research, Antwerp, 16-20 February, 1992

H.R. Schwietert and B. Wilffert:

Pharmacomechanical coupling of 1-adrenoceptors in the isolated rat portal vein.

33rd Spring Meeting of the German Society for Pharmacology and Toxicology,

Mainz, 10-12 March, 1992



U. Vollmer, P. Stoppie, J. Mesens, B. Wilffert and T. Peters:

Hydroxypropyl- -cyclodextrin in transdermal absorption in vivo in rats.

The Sixth International Cyclodextrin Symposium, Chicago, 21-24 April, 1992

Y. Xie, E. Zacharias, K. Dengler, B. Wilffert and F. Tegtmeier:

Blockade of glutamate receptors but not voltage-gated Ca++ channels attenuates ischemia-induced decline of extracellular calcium.

International Sympsoium on Pharmacology of Cerebral Ischemia, Marburg,

20-22 July, 1992

M. Henrichs, E. Scheufler, A. Mozes and B. Wilffert:

Nicardipine inhibits postischemic fibrillations in guinea pig hearts primarily by its cardiodepressant effect during ischemia.


Graz, 6-9 September, 1992

B. Wilffert:

Wirkungsmechanismen von Hemmern der Na/Ca-Überladung.

Deutsche Pharmazeutische Gesellschaft Landesgruppe Schleswig-Holstein,

Kiel, 16 November, 1992

B. Wilffert:

Wirkungsmechanismen von Hemmern der Na/Ca-Überladung.

Deutsche Pharmazeutische Gesellschaft Landesgruppe Hamburg e.V., 17 November, 1992

B. Wilffert:

Na/Ca-overload inhibitors.

Symposium on Drug Research, Amsterdam, 26-27 November, 1992

D. Wilhelm, E. Scheufler, M. Ebbert, I. Guttmann, A. Leidig and B. Wilffert:

Differential influence of R 59494 and its enantiomers on ouabain toxicity in rat left atria.

Meeting of the British Pharmacological Society, London, 05 07 January, 1993

J. Schneider, E. Beck, C. Heers and B. Wilffert:

Effects of positive inotropic agents on cardiac performance under conditions of increasing afterload in the stunned guinea-pig myocardium.

Meeting of the British Pharmacological Society, London, 05 07 January, 1993

H.R. Schwietert, H. Batink, B. Wilffert, M. Pfaffendorf and P.A. van Zwieten:

Pharmacological analysis of 1-adrenoceptor binding sites in rat left ventricular tissue with subtype selective antagonists.


E. Scheufler, M. Henrichs, I. Guttmann, A. Mozes and B. Wilffert:

Effect of the Na/H exchange inhibitor ethyl-isopropyl-amiloride (EIPA) during ischemia

and reperfusion.

Meeting of the British Pharmacological Society, London, January 05-07, 1993

P. Hennemann, C. Achenbach, D. Wilhelm, and B. Wilffert:

Na+-Ca2+ exchange during phase 1 of action potential in sheep heart Purkinje fibres.

72. Jahrestagung der Deutschen Physiologischen Gesellschaft, München, March 09-12, 1993

C. Heers, J. Schneider, E. Beck, and B. Wilffert:

Influence of positive inotropic agents on the regulation of cardiac output under conditions of increasingafterload in stunned myocardium.

34. Frühjahrstagung der Deutschen Gesellschaft für Pharmakologie und Toxikologie, Mainz, March 16-18, 1993

H. Rambold, K. Riedel, D. Wilhelm, B. Wilffert, P. Honerjäger:

R 56865 blocks open and inactivated states of the cardiac sodium channel.

34. Frühjahrstagung der Deutschen Gesellschaft für Pharmakologie und Toxikologie, Mainz, March



16-18, 1993

W. Reimann, N. Selve, W. Englberger, E. Friderichs, B. Wilffert:

Spinal antinociception by morphine in rats is antagonised by galanin receptor

antagonists.

34. Frühjahrstagung der Deutschen Gesellschaft für Pharmakologie und Toxikologie,

Mainz, March 16-18, 1993

W.S. Reimann, N. Selve, W. Englberger, E. Friderichs, B. Wilffert:

Antinociception by tramadol in rats is reversed by intrathecally injected galanin

antagonists.

1994 Annual Meeting of the Society for Neuroscience, Miami Beach,

Florida, November 13-18, 1994

B. Wilffert:

Targets for the development of new analgesics.

Second Symposium on Drug Research, Amsterdam, October 29-30, 1996

W.J. Tamminga, J. Wemer, B. Oosterhuis, B. Wilffert, J.H.G. Jonkman, L.F.M.H. de Ley, R.A. de Zeeuw:

Phenotyping and genotyping techniques used in clinical pharmacology studies.

GIDS Spring Meeting, June 1997

W.J. Tamminga, J. Wemer, B. Oosterhuis, B. Wilffert, J.H.G. Jonkman, L.F.M.H. de Ley, R.A. de Zeeuw:

The application of phenotyping and genotyping techniques in clinical pharmacology studies.

Mededelingendag van de Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie, Utrecht, October 1997

W.J. Tamminga, B. Oosterhuis, J. Wemer, J. Wieling, B. Wilffert, E.P. Sakiman, J.H.G. Jonkman, R.A. de Zeeuw, L.F.M.H. de Ley:

Mephenytoin as a marker for CYP2C19 enzyme activity.

Nederlandse Vereniging voor Farmaceutische Wetenschappen, NVFW Toogdag, Geneesmiddelenonderzoek in Nederland, Leiden, November 1997

B. Wilffert, W.J. Tamminga, J. Wemer, B. Oosterhuis, J. Wieling, J.H.G. Jonkman, L.F.M.H. de Ley, R.A. de Zeeuw:

Distribution of CYP2D6 and CYP2C19 phenotypes in Dutch male and female volunteers in clinical pharmacology studies.

39. Frühjahrstagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, Mainz, March 17-19, 1998

W.J. Tamminga, B. Oosterhuis, J. Wemer, J. Wieling, B. Wilffert, H. Poelman, R.A. de Zeeuw, L.F.M.H.de Ley, J.H.G. Jonkman:

CYP2C19 phenotyping and genotyping in Dutch volunteers in clinical pharmacology studies.

GIDS Spring Meeting, Groningen, May 29, 1998

J. Wemer, W.J. Tamminga, B. Oosterhuis, B.Wilffert, J. Wieling, J.H.G. Jonkman, R.A. de Zeeuw, L.F.M.H. de Ley:

Pharmacogenetic aspects of drug metabolism in drug development.

GIDS Spring Meeting, Groningen, May 29, 1998

B. Oosterhuis, W.J. Tamminga, J. Wemer, J. Wieling, B. Wilffert, E.P. Sakiman, R.A. de Zeeuw, L.F.M.H. de Ley, J.H.G. Jonkman:

Mephenytoin as a marker for CYP2C19 enzyme activity: influence of analytical factors on the outcomeof phenotyping.

European Symposium on Prediction of Drug Metabolism in Man: Progress and Problems, Luik, Belgium, May 19-20, 1998

W.J. Tamminga, B. Oosterhuis, J. Wemer, J. Wieling, B. Wilffert, H. Poelman, R.A. de Zeeuw, L.F.M.H.de Ley, J.H.G. Jonkman:

CYP2C19 activity in a large sample of the Dutch population.



12th International Symposium on Microsomes and Drug Oxidation, Montpellier, France, July 20-24, 1998

W.J. Tamminga, J. Wemer, B. Oosterhuis, J. Wieling, B. Wilffert, R.A. de Zeeuw, L.F.M.H. de Ley, J.H.G.

Jonkman:

Evidence for gender differences on CYP2C19 activity in Dutch healthy volunteers in clinical pharmacology studies.

Mededelingendag Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie, Utrecht, October 2, 1998

B. Wilffert, W.J. Tamminga, B. Oosterhuis, J. Wemer, J. Wieling, R.A. de Zeeuw, L.F.M.H. de Ley, J.H.G. Jonkman:

On the role of genotyping and phenotyping for the characterization of CYP2C19 activity as a tool for optimization of clinical pharmacology studies.

Fifth EUFEPS Conference ‚‘Optimising Drug Development: Fast tracking into Human‘, Wiesbaden, Germany, December 7-9, 1998

B. Wilffert:

De plaats van genotypering in de klinische praktijk: stand van zaken en toekomstverwachtingen.

NGZA-vergadering, Groningen, January 24, 2001

E.N. van Roon, L. Mourad, W.A. Baars, B.Wilffert, T.L.ThA. Jansen, J.R.B.J. Brouwers:

Efficacy, tolerability and discontinuation of leflunomide in unselected outpatients with rheumatoid arthritis.

5th Congress Eur Ass Clin Pharmacol & Ther. Odense, Denmark 12-15 September 2001

E.N. van Roon, T.L.Th.A. Jansen, L.Mourad, P.M. Houtman, G.A.W. Bruyn, E.N. Griep, W.A. Baars, B.Wilffert, H. Tobi, J.R.B.J. Brouwers:

Leflunomide in active rheumatoid arthritits: A prospective study in daily practice.


B.Wilffert, E.N. van Roon:

Klinische Pharmazie in den Niederlanden.

Fortbildung für Krankenhausapothekerinnen und –apotheker, Apothekerkammer Nordrhein gemeinsam mit dem ADKA-Landesverband Nordrhein-Westfalen e.V., Düsseldorf , September 14, 2002

E.N. van Roon, A.L.M. Kerremans , S. Flikweert, W.J.M. Kwee-Zuiderwijk, M. le Comte, B. Wilffert, J.R.B.J. Brouwers, on behalf of the Working Group on Pharmacotherapy and Drug Information, WINAp, The Hague, The Netherlands:

Structured assessment of the relevance of drug-drug interactions.

44. Frühjahrstagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und

Toxikologie, Mainz, March 17-20, 2003

A.F.Y. Al Hadithy, N.E. Ajubi, J. Slomp, J.R.B.J. Brouwers, H. Storm, B. Wilffert:

Determination of 5-HT2AR His452Tyr, 5-HT2AR 102T/C, and DRD2 –141C Ins/Del polymorphisms inwhole-blood and buccal swabs using PCR-RFLP genotyping.

3e bijeenkomst Werkgroep Farmacogenetica Nederland, Utrecht, October 30, 2003


Determination of the polymorphisms His452Tyr and 102T/C of 5-HT2A- and –141C Ins/Del of D2-receptors in whole-blood and buccal swabs using PCR-RFLP genotyping.



E.N. van Roon, N.A. Botta-Steeneken, T.L.Th.A. Jansen, B.Wilffert, J.R.B.J.Brouwers:

Optimization of antirheumatic leflunomide therapy by therapeutic drug monitoring.






Determination of 5-HT2aR His452Tyr, 5-HT2aR 102T/C, and DRD2 -141C Ins/Del polymorphisms in

whole-blood and buccal swabs using PCR-RFLP genotyping.

57e Congres van de Nederlandse Vereniging voor Klinische Chemie en Laboratoriumgeneeskunde, Lunteren, April 22-23, 2004

B.Wilffert, R.Bruggeman, J.R.B.J.Brouwers:

Farmacogenetica, antidepressiva en antipsychotica.

PUK Symposium Groningen: Nieuwe ontwikkelingen in de psychofarmacologie. Stichting Onderzoek Biologische Psychiatrie, Groningen, November 18, 2004

E.N. van Roon, M.D. Wu, F. Idzinga, P.M.L.A. van den Bemt, T.L.Th. A. Jansen, P.M. Houtman, M.A.F.J. van de Laar, B. Wilffert, J.R.B.J. Brouwers:

A multidisciplinary approach for the assessment of drug interactions with disease-modifying antirheumatic drugs.


B. Wilffert, J.R.B.J. Brouwers, A.J.M. Loonen and R.Bruggeman:

Farmacogenetica; past – present – future.

Symposium: ‘Het metabole syndroom belicht vanuit drie invalshoeken’, Assen, October 6, 2005

B. Wilffert, J.R.B.J. Brouwers and A.J.M. Loonen:

Workshop: Psychiatry, genetic profiling for psychiatric pharmacotherapy.

34th European Symposium on Clinical Pharmacy organised by the European Society of Clinical Pharmacy. Patient Profiling: Key to Successful Treatment, Amsterdam October 26-29, 2005

B.Wilffert, A.F.Y. Al Hadithy, J.R.B.J. Brouwers, K. Jangbahadoer Sing, G.E. Matroos, H.W. Hoek and P.N. van Harten:

A pharmacogenetic analysis of tardive dyskinesia in Afro-Caribbean psychiatric inpatients on long-term treatment with first generation antipsychotics.

Mededelingendag Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie, Utrecht, April21, 2006

R. Bruggeman, B.Wilffert, A.F.Y. Al Hadithy, K. Jangbahadoer Sing, G.E. Matroos, H.W. Hoek,

J. van Os, J.R.B.J. Brouwers,P.N. van Harten:

Tardive dyskinesia pharmacogenetics in Afro-Caribbean patients on neuroleptic treatment.

World Congress on Psychiatric Genetics, Cagliari, October 2006

B.Wilffert, A.F.Y. Al Hadithy, R. Bruggeman, J.R.B.J. Brouwers:

Genetic polymorphisms in the serotonergic pathways related to schizophrenia, depression, neuroleptic-induced extrapyramidal symptoms and ADHD.

Polymorphic genes, compromised adaptation organized by GGZ Drenthe, Zwolle, February 8, 2007

B.Wilffert, A.F.Y. Al Hadithy, R. Bruggeman, J.R.B.J. Brouwers:

Genetic polymorphisms in the dopaminergic pathways related to ADHD and neuroleptic-induced extrapyramidal symptoms.

Polymorphic genes, compromised adaptation organized by GGZ Drenthe, Zwolle, February 8, 2007

A.F.Y. Al Hadithy, B.Wilffert, R.E. Stewart, N.M.G. Looman, R. Bruggeman, J.R.B.J. Brouwers, G.E. Matroos, J. van Os, H.W. Hoek and P.N. van Harten:

Dopamine D2, serotonin 2A, and 2C receptor polymorphisms in Afro-Caribbean inpatients: differences in association with parkinsonism, tremor and rigidity.


M.K. Reinders, E.N. van Roon, P.M. Houtman, B. Wilffert, J.R.B.J. Brouwers, T.L.Th.A. Jansen:

Biochemical effectiveness of allopurinol monotherapy and allopurinol-probenecid combination therapy in previously benzbromarone-treated gout patients.




A.F.Y. Al Hadithy, B.Wilffert, R.E. Stewart, R. Bruggeman, J.R.B.J. Brouwers, G.E. Matroos, J. van Os,H.W. Hoek and P.N. van Harten:

Differences in association between dopamine D2, serotonin 2A, and 2C receptor polymorphisms and parkinsonism, tremor and rigidity in Afro-Caribbean inpatients.

Mededelingendag Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie, Utrecht, March 30, 2007

A.F.Y. Al Hadithy, B. Wilffert, R. Bruggeman, J.R.B.J. Brouwers, J. van Os, K. Jangbahadoer Sing, G.E. Matroos, H.W. Hoek, P.N. van Harten:

Pharmacogenetics of tardive dyskinesia in Afro-Caribbean inpatients on neuroleptic treatment.

International Congress on Schizophrenia Research, Colorado Springs, March 2007

A.F.Y. Al Hadithy, B.Wilffert, R.E. Stewart, R. Bruggeman, J.R.B.J. Brouwers, G.E. Matroos, J. van Os,H.W. Hoek and P.N. van Harten:

Polymorphisms of dopamine D2, serotonin 2A, and 2C receptors in relation to parkinsonism, tremor, rigidity and bradykinesia in male Afro-Caribbean patients.

European Association for Clinical Pharmacology and Therapeutics, Amsterdam, August 29- September 1, 2007

A.F.Y. Al Hadithy, B.Wilffert, R.E. Stewart, R. Bruggeman, J.R.B.J. Brouwers, G.E. Matroos, J.

van Os, H.W. Hoek, P.N. van Harten:

Polymorphisms of dopamine D2, serotonin 2A, and 2C receptors in relation to parkinsonism,

tremor, rigidity, and badykinesia in male Afro-Caribbean patients.

World Congress on Psychiatric Genetics, New York, October 2007



Lack of association between antipsychotic-induced parkinsonism, tremor, bradykinesia and

rigidity and the rs4606 SNP of the RGS2 gene in Afro-Caribbean inpatients.

Mededelingendag Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie, Utrecht, April11, 2008

A.F.Y. Al Hadithy, S.A. Ivanova, P. Pechlivanoglou, A. Semke, O. Fedorenko, E.

Kornetova, L. Ryadovaya, J.R.B.J. Brouwers, B. Wilffert , R. Bruggeman, A.J.M. Loonen:

Polymorphisms of dopamine D3, serotonin 2A and 2C receptors and orofacioloingual and limb-

truncal dyskinesias in Russian psychiatric inpatients from Siberia.

Dutch Society of Clinical Pharmacology and Biopharmacy, Utrecht, October 7, 2008

B.Wilffert:

Implementation of pharmacogenetics in clinical practice. Where are we standing now?

Nederlands Netwerk Onderzoek Farmacogenetica, Utrecht, October 15, 2009

A.J. Risselada, J. Vehof, R. Bruggemanm, B.Wilffert, D. Cohen, A.F.Y. Al Hadithy, J. Arends, H. Mulder:

Association between the alpha-2a-adrenergic receptor 1291C/G polymorphism and the metabolic syndrome.

Nederlandse ziekenhuisfarmaciedagen, Amersfoort, March 11 and 12, 2010

J. Vehof, A.F.Y. Al Hadithy, H. Burger , A.J. Risselada, B.Wilffert, D. Cohen, J. Arends, H. Mulder, R. Bruggemanm:

Antipsychotic-induced weight gain and rs1455832 polymorphism of the ROBO1 gene: association analysis in psychosis patients on antipsychotics.


A.J. Risselada, J. Vehof, R. Bruggemanm, B.Wilffert, D. Cohen, A.F.Y. Al Hadithy, J. Arends, H. Mulder:

Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: a replication study.


J. Vehof, A.F.Y. Al Hadithy, H. Burger , A.J. Risselada, B.Wilffert, D. Cohen, J. Arends, H. Mulder, R.



Bruggeman:

BMI and RS1455832 SNP of the ROBO1 gene: association analysis in patients using antipsychotics.

2nd Conference of the Schizophrenia-International-Research-Society (SIRS), Florence, Italy, April 10-14, 2010

P.G.J. ter Horst, S. van der Linde, M.T. Vries, J.P. Smit, J. den Boon, R.A. van Lingen, L.T.W. De

Jong- van den Berg, B. Wilffert:

Clomipramine in neonates: elimination kinetics and withdrawal symptoms after in utero exposure.

Mededelingendag Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie, Lunteren,

October 4, 2010



Pharmacokinetics and withdrawal reactions of clomipramine of in utero exposed neonates.

77. Jahrestagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und

Toxikologie, Frankfurt am Main, March 30 to April 1, 2011 (Naunyn-Schmiedeberg-Preis für

Pharmakologie 2011)

P.G.J. ter Horst, B. Wilffert, V. Tapper, J. den Boon, L.T.W. De Jong- van den Berg,:

The applicability of the brief medication questionnaire (BMQ) in pregnant women using

antidepressants

Mededelingendag Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie, Utrecht, April

8, 2011

J.J. Swen, M. Nijenhuis, A. de Boer, L. Grandia, A.-H. Maitland- van der Zee, H. Mulder, G.A.

Rongen, R.H.N. van Schaik, T. Schalekamp, D.J. Touw, J. van der Weide, B.Wilffert, V.H.M.

Deneer , H.J. Guchelaar:

Pharmacogenetics: From bench to byte.

Nederlandse ziekenhuisfarmaciedagen, Amersfoort, May 26 and 27, 2011

B.Wilffert:

KNMP/WinAp: Evidence-based doseringsvoorschriften voor elk genotype.

CMBD Themadag Farmacogenetica, Utrecht, November 18, 2011

B.Wilffert:

Pharmacogenetics of drug-induced birth defects.

Annual meeting of the Section Pharmaceutical Toxicology of the Dutch Society of Toxicology

on: “Personalized Drug Safety”, Leiden, February 2, 2012

B.Wilffert:

Farmacogenetica: implicaties voor de huisartsenpraktijk.

Symposium “Farmacogenetica implicaties voor de praktijk” gehouden ter gelegenheid van de CCKL certificering van het Farmacogenetisch, Farmaceutisch en Toxicologisch Laboratorium van het St. Antonius Ziekenhuis te Nieuwegein, September 7, 2012

P.G.J. ter Horst, H.J. Bos, L.T.W. De Jong- van den Berg B. Wilffert:

In utero exposure to antidepressants and the use of drugs for pulmonary diseases in children.

Dutch Medicine Days, Lunteren, October 1-3, 2012

B.Wilffert:

Farmacogenetica, is screening zinvol?

Lareb Bijwerkingendag 2012 ‘Preventie van bijwerkingen’, Utrecht, November 29, 2012

B.Wilffert, E.J.J. Berm, R.J. van Marum, J.R.B.J. Brouwers, P.A.F. Janssen, R.M. Kok, M.L. Stek,

T. Dhondt, L. Beuning, R.C. Oude Voshaar, M.L. Boshuisen, L.Grandia, H. Mulder, J.G.

Maring, A.C.G. Egberts, M.J. Postma, E. Hak:

Effects and cost-effectiveness of pharmacogenetic screening among elderly starters with

antidepressant: A pragmatic randomized controlled trial. (Sneller de juiste dosering van



antidepressiva bij ouderen). Cytochrome P450 Screening among Elderly (CYSCE).

ZonMw Congres Goed Gebruik Geneesmiddelen te Utrecht/Maarssen, January 31, 2013

J.P. Yska, R.J. Punter, H.J. Woerdenbag, J.A. Apers, M. Emous, E.R. Totté, H.W. Frijlink, B.

Wilffert, E.N. van Roon:

A gastrointestinal simulation system (GISS) for dissolution of drugs before and after Roux-enY

gastric bypass: first results.

Scientific Spring Meeting Dutch Society for Clinical Pharmacology and Biopharmacy, Utrecht,

March 26, 2013

E.J.J. Berm, E. Brummel-Mulder, J. Paardekooper, E. Hak, B. Wilffert, J.G. Maring:

Determination of venlafaxine and O-desmethylvenlafaxine in dried blood spots using

LC-MS/MS.

13th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Salt Lake

City, USA, September 22-26, 2013

E.J.J. Berm, J. Paardekooper, E. Brummel-Mulder, E.Hak, B. Wilffert, J.G. Maring:

Determination of the tricyclic antidepressants amitriptyline, nortriptyline, imipramine,

desipramine, clomipramine and desmethylclomipramine in dried blood spots using LC-MS/MS.

13th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, Salt Lake

City, USA, September 22-26, 2013

J.P. Yska, D.H. van der Meer, W. Eilander, A.R. Dreijer, J.A. Apers, M. Emous, E.R. Totté, B.


Influence of bariatric surgery on the use of some major drug classes.


Toxikologie, Hannover, April 1-3, 2014

B.Wilffert:

Individualization of pharmacotherapy by pharmacogenetics.

International Conference Pharmaceutical Care “New Development of Pharmaceutical Care in

Pharmacogenetic and Pharmacogenomic Approach”, Malang, Indonesia, April 19, 2014

B.Wilffert:

Geneesmiddelen op maat: farmacogenetica in de klinische praktijk.

PRISMA symposium 2014, Amersfoort, May 20, 2014

J.P. Martono, R. Lub, H.J. Lambers Heerspink, E. Hak, B. Wilffert, P. Denig:

Predictors of response in initial users of metformin and sulfonylurea derivatives: a systematic

review.

EuroDURG, Groningen, August 27-29, 2014 (Poster prize)

A.N.A. Daud, J.E.H. Bergman, M.K. Bakker, H. Wang, W.S. Kerstjens-Frederikse, H. Groen, E.

Hak, B. Wilffert :

P-glycoprotein-mediated drug interactions in pregnancy and the effect on the risk of congenital

anomalies.

FIGON Dutch Medicine Days, Ede, October 6-8, 2014

J.J. Gout-Zwart, E.J.J. Berm, J.G. Maring, B. Wilffert, M.J. Postma:

Cost-effectiveness of CYP2D6 genotyping in older depressed patients, starting with nortriptyline therapy.


A.N.A. Daud, J.E.H. Bergman, M.K. Bakker, H. Wang, W.S. Kerstjens-Frederikse, H. Groen, E.

Hak, B. Wilffert :

The effect of P-glycoprotein-mediated drug interactions in pregnancy on the risk of congenital

anomalies.



Safety of medication use in pregnancy, EUROmediCAT , European Conference, Poznan, Polen, February 2-4, 2015

Y.H. Tran, H. Wang, J.E.H. Bergman, H. Groen, M.K. Bakker, B. Wilffert :

Drugs acting via vascular disruption and related birth defects: a systematic review.

Safety of medication use in pregnancy, EUROmediCAT , European Conference, Poznan, Polen, February 2-4, 2015. Awarded with a Poster-prize.

E.J.J. Berm, R.M. Kok, E. Hak, B. Wilffert:

Relation between genotype, phenotype and therapeutic drug concentrations of nortriptyline or

venlafaxine users in old age psychiatry.


Toxikologie, Kiel, March 10-12, 2015

S. Begari, M. Duyvendak, P.I. van Haelst, B. Wilffert :

Enhanced surveillance of QTc interval prolongation using decision support software.


A.N.A. Daud, J.E.H. Bergman, M.K. Bakker, H. Wang, W.S. Kerstjens-Frederikse, H. Groen, J.

Bos, E. Hak, B. Wilffert :

Maternal use of drugs transported by placental transporters and the effect of drug interactions on

fetal drug exposure: a case reference study.


Y.H. Tran, J.E.H. Bergman, H. Wang, M.K. Bakker, H. Groen, B. Wilffert :

Oxidative stress-mediated teratogenesis and the role of folate.


E.J.J. Berm, B. Odigie, B. Wilffert, D.J. Touw, J.G. Maring:

Can differences in potassium based hematocrit explain deviations between DBS and plasma

Concentrations of antidepressants.

IADTMCT, 14th International Congress of Therapeutic Drug Monitoring and Toxicology

Rotterdam, October 11-15, 2015

B. Wilffert :

Farmacogenetica: Basis en praktijk.

WAD-cursus, What about genes environment and neurotransmission (WAGEN), Terschelling,

November 11, 2015

Y.H. Tran, J. Bergman, M. Bakker, H. Groen, B. Wilffert:

Oxidative-stress-mediated teratogenesis and the role of folate

German Pharm-Tox Summit, Berlin, February 29- March 3, 2016

PAPERS


De presynaptische -receptor, een mogelijk aangrijpingspunt voor farmaca.

Pharm. Weekbl. 114, 245-255, 1979

J.C.A. van Meel, A. de Jonge, H.O. Kalkman, B. Wilffert, P.B.M.W.M. Timmermans and

P.A. van Zwieten:

Vascular smooth muscle contraction initiated by postsynaptic 2-adrenoceptor activation is induced by an influx of extracellular calcium.

Eur. J. Pharmacol. 69, 205-208, 1981

A.J. Porsius, B. Wilffert, G. Lambrecht, U. Moser and E. Mutschler:

Muscarinic effects of various isoarecaidine esters in sympathetic ganglia.

J. Auton. Pharmacol. 1, 119-126, 1981

A. de Jonge, B. Wilffert, H.O. Kalkman, J.C.A. van Meel, M.J.M.C. Thoolen,




Captopril impairs the vascular smooth muscle contraction mediated by postsynaptic 2-adrenoceptors in the pithed rat.

Eur. J. Pharmacol. 74, 385-386, 1981

J.C.A. van Meel, A. de Jonge, B. Wilffert, H.O. Kalkman, P.B.M.W.M. Timmermans and

P.A. van Zwieten:

Organic and inorganic calcium antagonists reduce vasoconstriction in vivo mediated by postsynaptic 2-adrenoceptors.

Naunyn-Schmiedeberg's Arch. Pharmacol. 316, 288-293, 1981

B. Wilffert:

Localization of - and -adrenoceptors.

Naunyn-Schmiedeberg's Arch. Pharmacol. 316 (suppl.), R56, 1981

B. Wilffert, M.A.M. Gouw and P.B.M.W.M. Timmermans:

Innervation of vascular - and -adrenoceptors in the normotensive rat.

Naunyn-Schmiedeberg's Arch. Pharmacol. 319 (Suppl.), R 67, 1982

P.B.M.W.M. Timmermans, B. Wilffert and P.A. van Zwieten:

Extrasynaptic location of vascular 2- and 2-adrenoceptors in the normotensive rat.

Br. J. Pharmacol. 75, 72P, 1982

A. de Jonge, B. Wilffert, H.O. Kalkman, M.J.M.C. Thoolen, J.C.A. van Meel,


Effect of captopril on the regulation of noradrenaline release in the heart and vascular smooth muscle of the pithed rat.


J.C.A. van Meel, B. Wilffert, H.O. Kalkman, M.J.M.C. Thoolen, A. de Jonge,


2-Adrenergic pressor responses and corticosteroids in the pithed rat.


P.B.M.W.M. Timmermans, B. Wilffert, H.O. Kalkman, M.J.M.C. Thoolen, J.C.A. van Meel,


Selective inhibition of 2-adrenoceptor-mediated vasoconstriction in vivo by captopril and MK-421.



Extrasynaptic location of alpha-2 and noninnervated beta-2 adrenoceptors in the vascular system of the pithed normotensive rat.

J. Pharmacol. Exp. Ther. 221, 762-768, 1982

B. Wilffert, M.A.M. Gouw, A. de Jonge, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Interaction between 1/ 2-adrenergic and 2-adrenergic effects.

Pharm. Weekbl. Scientif. Edition 4, 163, 1982

P.A. van Zwieten, J.C.A. van Meel, A. de Jonge, B. Wilffert and P.B.M.W.M. Timmermans:

Central and peripheral -adrenoceptors.

J. Cardiovasc. Pharmacol. 4 (Suppl.), S19-S24, 1982

J.C.A. van Meel, B. Wilffert, K. de Zoeten, P.B.M.W.M. Timmermans and P.A. van Zwieten:

The inhibitory effect of newer calcium antagonists (nimodipine and PY-108-068) on vasoconstriction invivo mediated by postsynaptic 2-adrenoceptors.

Arch. Int. Pharmacodyn. Ther. 260, 206-217, 1982


Indications for vascular alpha-2 and beta-2 adrenoceptors in synapses of the muscarinic pathway in the pithed normotensive rat.




A. de Jonge, J. Th. A. Knape, J.C.A. van Meel, H.O. Kalkman, B. Wilffert, M.J.M.C. Thoolen,


Effect of converting enzyme inhibition and angiotensin receptor blockade on the vaso-constriction mediated by 1- and 2-adrenoceptor stimulation in pithed normotensive rats.



Cardiovascular effects of dopamine and some methylated and fluorinated derivatives in pithed normotensive rats.

Pharmacology 27, 140-149, 1983

D. Davidesko, P.B.M.W.M. Timmermans, B. Wilffert and P.A. van Zwieten:

-Adrenoceptor-mediated vasoconstriction in the pithed rat induced by stimulation of subclasses of ganglionic muscarinic receptors.

Br. J. Pharmacol. 78, 69P, 1983.

A. de Jonge, J. Th. A. Knape, J.C.A. van Meel, H.O. Kalkman, B. Wilffert, M.J.M.C. Thoolen,

P. van Brummelen, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Effect of captopril on sympathetic neurotransmission in pithed normotensive rats.

Eur. J. Pharmacol. 88, 231-240, 1983

P.B.M.W.M. Timmermans. B. Wilffert, D. Davidesko, M.J. Mathy, D. Dijkstra, A.S. Horn

and P.A. van Zwieten:

Re-evaluation of the selectivity of 2-N,N-dimethylamino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene (M-7) as an agonist of postjunctional alpha-2 adrenoceptors in the pithed normotensive rat.


B. Wilffert, D. Davidesko, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Differential role of M-1 and M-2 receptors in sympathetic ganglia of the pithed normotensive rat in alpha-adrenoceptor mediated vasoconstriction.



Interaction between 2-adrenoceptor mediated vasodilation and 2-adrenoceptor mediated vasoconstriction in the pithed normotensive rat.

J. Cardiovasc. Pharmacol. 5, 822-828, 1983


Interaction between 2-adrenoceptor mediated vasodilation and 1-adrenoceptor mediated vasoconstriction in the pithed normotensive rat.


M.J.M.C. Thoolen, J.C.A. van Meel, B. Wilffert, P.B.M.W.M. Timmermans and

P.A. van Zwieten:

Hemodynamic characterisation of pinacidil in rats. Comparison with hydralazine.

Pharmacology 27, 245-254, 1983

J.C.A. van Meel, J. Qian, B. Wilffert, A. de Jonge P.B.M.W.M. Timmermans and

P.A. van Zwieten:

Effect of adrenalectomy and demedullation of the adrenals on vasopressor responses to stimulation ofpostjunctional 2-adrenoceptors.

Eur. J. Pharmacol. 91, 171-179, 1983

B. Wilffert, D. Davidesko, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Role of ganglionic M-1 and M-2 receptors in the neuronal control of the cardiovascular system of the normotensive rat as determined with pilocarpine.

Eur. J. Pharmacol. 95, 109-116, 1983

P.B.M.W.M. Timmermans, M.J. Mathy, B. Wilffert, H.O. Kalkman, M.J.M.C. Thoolen,

A. de Jonge, J.C.A. van Meel and P.A. van Zwieten:



Differential effect of calcium entry blockers on 1-adrenoceptor-mediated vasoconstriction in vivo.


M.J. Mathy, H.N. Doods, M.J.M.C. Thoolen, B. Wilffert, A. de Jonge,


Selective stimulation of vascular postjunctional 1-adrenoceptors by (-)-amidephrine in rats and cats.


P.B.M.W.M. Timmermans, M.J.M.C. Thoolen. M.J. Mathy, B. Wilffert, A. de Jonge and

P.A. van Zwieten:

Sgd 101/75 is distinguished from other selective 1-adrenoceptor agonists by the inhibition of its pressor responses by calcium entry blockade and vasodilation in pithed rats and cats.

Eur. J. Pharmacol. 96, 187-192, 1983

B. Wilffert:

The interference between 1- and 2-adrenoceptor-mediated vascular effects in the pithed normotensive rat. Indications for two populations of 1-adrenoceptors.

Naunyn-Schmiedeberg's Arch. Pharmacol. 322, R70, 1983

M.A.M. Gouw, A. de Jonge, P.B.M.W.M. Timmermans, M.J.M.C. Thoolen, B. Wilffert and P.A. van Zwieten:

Indications for different locations of 2-adrenoceptors in the rat demonstrated by 2-adrenoceptor- mediated vasodilatation.



Differential effect of D 600 on contractions of rat and guinea-pig aorta by different 1-adrenoceptor agonists.



1-Adrenoceptor agonism of cirazoline and St 587 on rat isolated aorta.



Effect of captopril and nifedipine on the noradrenaline-induced vasoconstriction in cats.



1-Adrenoceptor subtypes in vascular smooth muscle of the pithed rat; discrimination by calcium entry blockade.



Further subclassification of vascular 2-adrenoceptors.



Role of ganglionic M-1 and M-2 receptors in the innervation of the cardiovascular system of the normotensive rat studies with pilocarpine.



P.A. van Zwieten:



M.J.M.C. Thoolen, J.J. Beckeringh, B. Wilffert, A. de Jonge, P.B.M.W.M. Timmermans and P.A. van



Zwieten:

Calcium entry blockade and 1-adrenoceptor mediated contractions of rat and guinea-pig isolated aortas.


P.B.M.W.M. Timmermans, M.J. Mathy, C. Korstanje, M.J.M.C. Thoolen, B. Wilffert,


Phenoxybenzamine identifies calcium influx dependent and independent mechanisms of vasoconstriction in vivo to cirazoline.

Naunyn-Schmiedeberg's Arch. Pharmacol. 324, R 14, 1983


Absence of antagonist selectivity for 1-adrenoceptors mediating calcium dependent and independent vasoconstriction in vivo.


F.A.M. Jonkman, M.J.M.C. Thoolen, B. Wilffert, A. de Jonge, P.B.M.W.M. Timmermans


Effects of PTH and vitamin D3 on plasma calcium level, blood pressure and sensitivity to calcium entry blockade in rats.



Characterization of -adrenoceptor populations on rat and guinea-pig isolated aortas.


F.A.M. Jonkman, M.J.M.C. Thoolen, A. de Jonge, B. Wilffert, P.B.M.W.M. Timmermans


The effect of salbutamol on the clonidine withdrawal tachycardia in rats.

Pharm. Weekbl. Sci. Ed. 264, 1983


A different role for M-1 and M-2 receptors in the sympathethic ganglia innervating the cardiovascular system of the normotensive rat studied with pilocarpine.

Pharm. Weekbl. Sci. Ed. 5, 266, 1983


Indications for two populations of vascular 2-adrenoceptors.



Differential effects of the calcium entry blocker D 600 on contractions of rat and guinea-pig aortas, elicited by various alpha-1 adrenoceptor agonists.



Antagonists do not dircriminate between Ca2+-influx dependent and -independent mechanisms of 1-adrenoceptor mediated vasoconstriction in pithed rats.


P.B.M.W.M. Timmermans, M.J. Mathy, B. Wilffert, H.O. Kalkman, G. Smit, D. Dijkstra,

A.S. Horn and P.A. van Zwieten:

1/ 2-Adrenoceptor agonist selectivity of mono- and dihydroxy-2-N,N-di-n-propylamino-tetralins.

Eur. J. Pharmacol. 97, 55-65, 1984

A. de Jonge, B. Wilffert, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and P.A. van Zwieten:



Differential prejunctional effect of captopril and saralasin on neurogenic vasoconstriction in pithed normotensive rats.

Life Sci. 34, 1433-1439, 1984


Differential effects of the calcium entry blocker D 600 on contractions of rat and guinea-pig aortas, elicited by various alpha-1 adrenoceptor agonists.


B. Wilffert, G. Smit, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and

P.A. van Zwieten:

Inhibitory dopamine receptors on sympathetic neurons innervating the cardiovascular system of the pithed rat. Characterization and role in relation to presynaptic 2-adrenoceptors.


A. de Jonge, D. Davidesko, M.-J. Mathy, M.J.M.C. Thoolen, B. Wilffert, P. van Brummelen,


Effect of pithing on the postjunctional sympatho-inhibitory action of captopril in cats.


B. Wilffert and P.M.M. van Heiningen:

Interaction between the putative calcium entry promotor Bay k 8644 and 1- and 2-adrenoceptor- mediated pressor responses in pithed rats.


H.N. Doods, H.O. Kalkman, A. de Jonge, B. Wilffert, M.J.M.C. Thoolen,


Preference of RU 24969 and pindolol for the purported 5-HT1B binding site, correlation between 5-HT1A affinity and hypotensive activity.


B. Wilffert, P.N.M. van Heiningen, M.-J. Mathy, H.D. Batink, A. de Jonge,

M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Lack of relationship between intrinsic activity and susceptibility of pressor responses to blockade by nifedipine among the 2-adrenoceptor agonists B-HT 920 and B-HT 958.


B. Wilffert, D. Davidesko, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Interaction between the calcium entry blocker nifedipine with the 1-adrenoceptor-mediated increasein diastolic pressure elicited by catecholamines.


B. Wilffert, P.N.M. van Heiningen, M.-J. Mathy, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Interactions between the putative calcium entry promotor Bay k 8644 and pressor responses produced by 1- and 2-adrenoceptor agonists in the pithed normotensive rat.



Heterogeneity of the interaction between 1- and 2-adrenoceptor agonists with their respective receptors in the vascular system of the pithed rat.

Eur. J. Pharmacol. 105, 121-127, 1984

B. Wilffert:

Catecholaminereceptoren in het perifere sympathische zenuwstelsel van de rat.

Pharm. Weekbl. 119, 1068-1072, 1984


Adrenoceptoren in het hart.



Hart Bulletin 15, 169-174, 1984

P.B.M.W.M. Timmermans, A. de Jonge, M.J.M.C. Thoolen, B. Wilffert, H. Batink and

P.A. van Zwieten:

Quantitative relationships between -adrenergic activity and binding affinity of

-adrenoceptor agonists and antagonists.

J. Med. Chem. 27, 495-503, 1984




A. de Jonge, G. Smit, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans, B. Wilffert and

P.A. van Zwieten:

Inhibitory dopamine receptors and 2-adrenoceptors on sympathetic neurons innervating the cardiovascular system of the rat.



Postjunctional 1-adrenoceptor mediated modulation of cardiac sympathetic neurotransmission in rats.


A. de Jonge, M.J. Mathy, P.B.M.W.M. Timmermans, M.J.M.C. Thoolen, B, Wilffert and

P.A. van Zwieten:

Inhibition of vasoconstriction to cirazoline in pithed rats by nifedipine after phenoxybenzamine.



The contractions induced in rat and guinea-pig aortic strips by the 2-adrenoceptor selective agonistsB-HT 920 and UK 14,304 are mediated by 1-adrenoceptors.

Eur. J. Pharmacol. 104, 197-203, 1984



Actua Sandoz 8, Proceedings Symposium "Physiological Receptor Antagonism.

An attempt to a perspective", Basel, March 1-2, 116-129, 1984

P.B.M.W.M. Timmermans, W.D. Matthews, R.M. Demarinis, J.P. Hieble, M.J. Mathy,

H.D. Doods, M.J.M.C. Thoolen, B. Wilffert and P.A. van Zwieten:

1-Adrenoceptor-mediated vasoconstriction in vivo to enantiomers of SK & F 89748-A.

Eur. J. Pharmacol. 101, 45-55, 1984

P.B.M.W.M. Timmermans, M.J. Mathy, M.J.M.C. Thoolen, A. de Jonge, B. Wilffert and

P.A. van Zwieten:

Invariable susceptibility to blockade by nifedipine of vasoconstriction to various 2-adreno¬ceptor agonists in pithed rats.

J. Pharm. Pharmacol. 36, 772-775, 1984



Effect of chronic elevation of plasma calcium concentration by PTH or vitamin D3 on blood pressure and hypotensive activity of nifedipine in rats.

Pflügers Arch. 402, 341-344, 1984

C. Korstanje, B. Wilffert, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and P.A. van Zwieten:



Calcium influx-dependent and -independent 1-adrenoceptor mediated processes of vasoconstriction in vivo do not operate via different 1-adrenoceptor subtypes.


C. Korstanje, H.N. Doods, A. de Jonge, M.J.M.C. Thoolen, B. Wilffert,


Affinity of WY 26703 for central and peripheral 1- and 2-adrenoceptors in the rat; comparison with yohimbine.


P.A. van Zwieten, M.J. Mathy, M.J.M.C. Thoolen, B. Wilffert, A. de Jonge and

P.B.M.W.M. Timmermans:

Effects of urapidil on blood pressure and adrenoceptors in various animal models.

J. Hypertension 2 (Suppl.3), 539-541, 1984



Effect of salbutamol and the PDE-inhibitor RA 642 on the clonidine withdrawal syndrome in rats.


B. Wilffert, M.J. Mathy, H.D. Batink, A. de Jonge, M.J.M.C. Thoolen, G. Prop, E. Graf,


Interference of enantiomers of lofexidine with -adrenoceptors.

Arch. int. Pharmacodyn. Ther. 273, 18-32, 1985

B. Wilffert, M.-J. Mathy, A. de Jonge, M.J.M.C. Thoolen, P.B.M.W.M. Timmermans and

P.A. van Zwieten

Influence of Bay k 8644 on pressor effects to B-HT 920 and cirazoline in pithed cats.




Br. J. Pharmacol. 84, 178 P, 1985

P.A. van Zwieten, P.B.M.W.M. Timmermans, M.J.M.C. Thoolen, B. Wilffert and A. de Jonge:

Interactions between calcium entry blockers and vascular -adrenoceptors.

In: Vascular Neuroeffector Mechanisms, J.A. Bevan et al. (Eds.).

Elsevier Science Publishers B.V., 97-102, 1985

H.N. Doods, H.O. Kalkman, A. de Jonge, M.J.M.C. Thoolen, B. Wilffert,


Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and

5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity.

Eur. J. Pharmacol. 112, 363-370, 1985

P.B.M.W.M. Timmermans, M.J.M.C. Thoolen, A. de Jonge, B. Wilffert and P.A.van Zwieten:

Calcium entry and -adrenoceptor-induced vasoconstriction in vivo and in vitro:

H. Refsum, O.D. Mjo/s (eds.): -Adrenoceptor blockers in cardiovascular disease. Churchill, London, 30-50, 1985

P.B.M.W.M. Timmermans, M.J.M.C. Thoolen, M.-J. Mathy, B. Wilffert, A. de Jonge and

P.A. van Zwieten:

Effects of the irreversible -adrenoceptor antagonists phenoxybenzamine and benextramine on the effectiveness of nifedipine in inhibiting 1- and 2-adrenoceptor mediated vasoconstriction in pithed rats.


P.B.M.W.M. Timmermans, M.J.M.C. Thoolen, A. de Jonge, B. Wilffert and P.A. van Zwieten:



Functional consequences of contrasting properties of 1/ 2 systems.

Clin. Sci. 68 (Suppl. 10), 93S 97S, 1985

P.A. van Zwieten, A. de Jonge, B. Wilffert, P.B.M.W.M. Timmermans, J. J. Beckeringh

and M.J.M.C. Thoolen:

Cardiovascular effects and interaction with adrenoceptors of urapidil.

Arch. int. Pharmacodyn. Ther. 276, 180 201, 1985


Calcium dependency of vasoconstriction mediated by 1 and 2 adrenoceptors.

J. Cardiovasc. Pharmacol. 7(Suppl. 6), S113 S120, 1985


Mechanismen der blutdrucksenkenden Aktivität von Calcium Entry Blockern (Kalziumantagonisten). Interaktion mit Adrenorezeptoren.

In: Hochdrucktherapie Mechanismen und Konzepte, H.J. Dengler, D. Palm (Eds.).

Schattauer, Stuttgart New York, 129 148, 1985

A. de Jonge, G. van den Berg, J.Q. Qian, B. Wilffert, M.J.M.C. Thoolen,


Inhibitory effect of 1 adrenoceptor stimulation on cardiac sympathetic neurotransmission in pithed normotensive rats.

J. Pharmacol. Exp. Ther. 236, 500 504, 1986

B. Wilffert:


Progr. Pharmacol. 6, 47 64, 1986

A. de Jonge, J.C.A. van Meel, B. Wilffert, P.B.M.W.M. Timmermans and P.A. van Zwieten:

Adrenoceptors in the cardiovascular system.

Progr. Pharmacol. 6, 15 35, 1986

P.A. van Zwieten, M.J.M.C. Thoolen, F.A.M. Jonkman, B. Wilffert, A. de Jonge and P.B.M.W.M. Timmermans:

Central and peripheral effects of S 3341 [(N-dicyclopropylmethyl)-amino-2-oxazoline] in animal models.

Arch. Int. Pharmacodyn. Ther., Vol. 279, 130-149, 1986

H.W.G.M. Boddeke, J.B. Heynis, R. Veldsema Currie, B. Wilffert and P.A. van Zwieten:

Anti ischaemic properties of R 58735 in isolated heart preparations.


H.W.G.M. Boddeke, J.B. Heynis, B. Wilffert and P.A. van Zwieten:

A study on the mechanism of negative inotropy of some calcium entry blockers in isolated guinea pig hearts.


D. Wilhelm, B. Wilffert, D. Wermelskirchen, B.L. Pegram, J. Hunter and U. Nebel:

An alternative method for the measurement of 45Ca influx in rat aorta.

Naunyn Schmiedeberg's Arch. Pharmacol. 335, R50, 1987

H.W.G.M. Boddeke, B. Wilffert, J.B. Heynis, V. van de Haar Keuken, F.A.M. Jonkman and P.A. van Zwieten:

A comparison of the cardiac and vasodilatory effects of some calcium entry blockers in perfused isolated guinea pig hearts.

Arch. int. Pharmacodyn. Ther. 288, 175 185, 1987


A comparitive study of calcium channels in jugular vein and aorta of the rat.


D. Wermelskirchen, D. Wilhelm, B. Wilffert, B.L. Pegram, J. Hunter, U. Nebel and Th. Peters:



Measurement of slowly exchanging 45Ca in rat aorta without using EGTA or lanthanum and its application to quantify the effects of the calcium entry blockers nifedipine and verapamil.

Pharmacology 36, 84 90, 1988.

H.W.G.M. Boddeke, B. Wilffert, J.B. Heynis and P.A. van Zwieten:

Investigation of the mechanism of negative inotropic activity of some calcium antagonists.

J. Cardiovasc. Pharmacol. 11, 321 325, 1988.

H. Kyle, J. G. Widdicombe and B. Wilffert:

Comparison of mucus flow rate, radiolabelled glycoprotein output and smooth muscle contraction in the ferret trachea in vitro.

Br. J. Pharmacol. 94, 293 298, 1988.

H.W.G.M. Boddeke, B. Wilffert, T.J.W. Jap and J.G. Hugtenburg:

Differential anti ischaemic effects of nifedipine and R 58735 in the guinea pig heart lung preparation.


P. Koch, D. Wilhelm, D. Wermelskirchen, B.L. Pegram, J. Hunter, U. Nebel, B. Wilffert and T. Peters:

A comparison of the effect of R 56865 on K+ induced contraction and increase in slowly exchanging 45Ca in the rat aorta.


P. Koch, D. Wilhelm, D. Wermelskirchen, U. Nebel, B. Wilffert and T. Peters:

The antagonistic effect of R 56865 on 1 adrenoceptor mediated contraction in isolated rat and guinea pig aorta.


J. Schneider, E. Beck, B. Wilffert and T. Peters:

A dose dependent inhibition of digitalis induced toxicity by R 56865 in the guinea pig heart lung preparation.



The antiarrhytmic effects of R 56865 in cardiac glycoside toxicity are not caused by inhibition of receptor binding.


B. Wilffert, D. Wermelskirchen and U. Nebel:

Comparison between the effects of calcium entry blockers and R 56865 on K induced contraction andincrease in slowly exchanging 45Ca in isolated rat aorta.

Naunyn Schmiedeberg's Arch. Pharmacol. 337 (Suppl.), R53, 1988

H.W.G.M. Boddeke, B. Wilffert, J.B. Heynis, J.G. Hugtenburg, W.T.J. Jap,

R.D. Veldsema Currie and P.A. van Zwieten:

The anti ischaemic activity of the novel compound CERM 11956, compared with that of bepridil and nifedipine in isolated guinea pig hearts.

Eur. J. Pharmacol. 149, 195 203, 1988

E. Scheufler, R. Vogelgesang, B. Wilffert, B.L. Pegram, J. Hunter, D. Wermelskirchen and

T. Peters:

Uptake of catamphiphilic drugs into erythrocytes and muscular tissue correlates to 45Ca displacementfrom phosphatidyl serine monolayers.



The antagonistic effects of R 56865 and derivatives on the NA induced contraction in the isolated rat aorta.



Calcium entry blockers underestimate the Ca2+ influx component of agonist induced contractions in the jugular vein and aorta of the rat.




H.W.G.M. Boddeke, B. Wilffert, J.G. Hugtenburg, T.J.W. Jap, R.D. Veldsema Currie and P.A. van Zwieten:

Anti ischaemic activity of various calmodulin antagonists.

Pharmacology 37, 240 247, 1988

P. Koch, D. Wilhelm, D. Wermelskirchen, U. Nebel, B. Wilffert, T. Peters:

Different effects of R 56865 and calcium entry blockers on K+- and noradrenaline-induced contractions and 45Ca uptake in rat aorta.

Eur. J. Pharmacol. 158, 183-190, 1988

P. Koch and B. Wilffert:

An approach to differentiate among noradrenaline elicited contractile processes by means of Ca2+ entry blockers, H 7 and ryanodine.

Naunyn Schmiedeberg's Arch. Pharmacol. 339, R92, 1989


Effects of calcium entry blocking agents on 5 hydroxytryptamine and noradrenaline induced contractions of rat isolated jugular vein and aorta.

Naunyn Schmiedeberg's Arch. Pharmacol. 339, 533 539, 1989


Different sensitivities for four calcium entry blockers of serotonin but not K+ induced contractions of isolated jugular vein and aorta of the rat.


P. Koch, J. Schneider, C. Fruh, D. Wilhelm, B. Wilffert and T. Peters:

Interaction between R 56865 and adrenoceptors in the pithed rat.

Arch. Int. Pharmacodyn. 299, 134 143, 1989

D. Wermelskirchen, B. Wilffert, U. Nebel and T. Peters:

Effects of R 56865 and R 70608 on the veratridine induced 45Ca uptake in rat aortic strips.



R 56865 differentiates between contractile agents with respect to the nifedipine sensitive component in the isolated rat aorta.


H.W.G.M. Boddeke, T.J.W. Jap, J.G. Hugtenburg, J.B. Heynis, R.D. Veldsema Currie,

B. Wilffert and P.A. van Zwieten:

Protective activity of nifedipine and R 58735 upon damage caused by global ischemia in the guinea pig heart lung preparation.

Basic Res. Cardiol. 84, 489 498, 1989

D. Wermelskirchen, P. Koch, U. Nebel, A. Leidig, B. Wilffert and T.Peters:

Effect of calmodulin antagonists on contraction and 45Ca movements in rat aorta.


B. Wilffert, D. Wermelskirchen, P. Koch, D. Wilhelm and T. Peters:

A comparison between contraction and increase in slowly exchanging 45Ca in the isolated rat aorta.

E. Reid, G.M.W. Cook and J.P. Luzio (Eds.): Biochemical approaches to cellular calcium. Royal Society of Chemistry,

Letchworth, England, 73-80, 1989

D. Wilhelm, B. Wilffert and T. Peters:

Cardiac glycoside intoxication: A model for the search for anti ischemic drugs?

Progr. Pharmac. Clin. Pharmac. 8, 37-51, 1990

B. Wilffert, T. Peters:

Searching for new antiischemic compounds: Theoretical and practical aspects. Deecke, Eccles,



Mountcastle (Eds.): From neuron to action: An appraisal of fundamental and clinical research.

Springer Verlag, 523-526, 1990

J.G. Hugtenburg, K. Belsner, A. Mozes, E. Scheufler and B. Wilffert:

Effect of nifedipine, mioflazine and dipyridamole on interstitial adenine nucleotide catabolites during global ischaemia in guinea pig hearts.

Br. J. Pharmacol. 99, 20 P, 1990.


Noradrenaline induced Ca2+ influx in the isolated guinea pig aorta.

Br. J. Pharmacol. 99, 43 P, 1990.

E. Scheufler, R. Vogelgesang, B. Wilffert, B.L. Pegram, J.B. Hunter, D. Wermelskirchen and T. Peters:

Uptake of catamphiphilic drugs into erythrocytes and muscular tissue correlates to membrane enrichment and to 45Ca displacement from phosphatidylserine monolayers.

J. Pharmacol. Exp. Ther. 252, 333 338, 1990

J. Schneider, C. Fruh and B. Wilffert:

Nebivolol does not interact with the purinergic neurotransmission in pithed normotensive rats.

Naunyn Schmiedeberg's Arch. Pharmacol. 341, R 59, 1990


Effects of the selective ß1 adrenoceptor antagonist, nebivolol, on cardiovascular parameters in the pithed normotensive rat.


P. Koch, B. Wilffert and T. Peters:

R 56865: A new anti ischemic principle.

Card. Drug Rev. 8, 238 254, 1990

P. Koch, B. Wilffert, D. Wilhelm and T. Peters:

An approach to differentiate between noradrenaline elicited contractile processes in the rat isolated aorta.

Naunyn Schmiedeberg's Arch Pharmacol 342, 454 461, 1990

D. Wilhelm, E. Velten, A. Leidig, B. Wilffert and T. Peters:

Diltiazem discriminates between different stimuli of calcium entry.

Eur. J. Pharmacol. 183, 1336, 1990

D. Wermelskirchen, B. Wilffert, U. Nebel, A. Wirth, A. Leidig and T. Peters:

Effects of R 56865 and R 59494 on veratridine induced 45Ca movements in rat isolated aortae and left atria.

Eur. J. Pharmacol. 183, 605 606, 1990

D. Wilhelm, A. Leidig, C. Meuter, B. Wilffert and T. Peters:

Cardiac in vitro pharmacology of the positive inotropic compound R 80122.

Eur. Heart J. 11, 19, 1990


The role of 1 adrenoceptor subtypes in the phasic and tonic responses to phenylephrine in the longitudinal smooth muscle of the rat portal vein.

Pharm. Weekbl. Sci. Ed. 12, H 11, 1990


Effects of inorganic cations on K+ , 5 hydroxytryptamine and noradrenaline induced contractions of the isolated rat jugular vein and aorta.

Eur. J. Pharmacol. 185, 147 155, 1990


Ca2+ Influx insensitive to organic Ca2+ entry blockers contributes to oradrenaline induced contractions of the isolated guinea pig aorta.




C. Wermelskirchen, J. Urenjak, B. Wilffert and F. Tegtmeier:

Detection of Na+ and Ca2+ movements by co measuring O2 consumption and 45Ca2+ uptake in rat cortical synaptosomes.

In: Cell signalling: Experimental strategies. E. Reid, G.M.W. Cook and J.P. Luzio (Eds).

Royal Society of Chemistry, Cambridge, 369-372, 1991

B. Wilffert and A. de Jonge:

Inhibitory prejunctional DA receptors on sympathetic nerves.

J. Feigenbaum, M. Hanani (Eds.): Presynaptic Regulation of Neurotransmitter release.

Freunds Publishing House, Ltd., London, 1081-1083, 1991.

D. Wermelskirchen, U. Nebel, A. Wirth and B. Wilffert:

45Ca2+ movements induced by Ca2+ chloride in isolated rat aorta under K+ free conditions.

Eur. J. Pharmacol., 192, 403 408, 1991


ß Adrenoceptor blocking properties of dl nebivolol and its enantiomers in the pithed

normotensive rat.

Drug Investigation, 3(Suppl.1), 123-128, 1991

B. Wilffert:

In pressor responses in pithed rats 1 adrenoceptor mediated Ca influx and Ca release from intracellular stores are not initiated by 1a and 1b adrenoceptors, respectively.

Naunyn Schmiedeberg's Arch. Pharmacol., 343, R97, 1991


Differential effect of R 56865 on ouabain binding to isolated sarcolemma and intact atrial tissue of guinea pig.

Br. J. Pharmacol. 102, 675 678, 1991

H.R. Schwietert, M.A.M. Gouw, D. Wilhelm, B. Wilffert and P.A. van Zwieten:

The ability of some adrenoceptor antagonists to enhance the spontaneous myogenic acitivity in therat portal vein shows no correlation with their adrenoceptor blocking properties.

Blood Vessels 28, 332 333, 1991

H.R. Schwietert, M.A.M Gouw, D. Wilhelm, B. Wilffert and P.A. van Zwieten:

The role of 1 adrenoceptor subtypes in the phasic and tonic responses to phenylephrine in the longitudinal smooth muscle of the rat portal vein.


D. Wermelskirchen, B. Wilffert, U. Nebel, A. Wirth, and T. Peters:

Veratridine-induced intoxication in the isolated left atrium of the rat: Effects of some anti-ischemic compounds.


H.R. Schwietert, D. Wilhelm, B. Wilffert, and P.A. van Zwieten:

Differences between full and partial -adrenoceptor agonists in eliciting phasic and tonic types of responses in the longitudinal smooth of the rat portal vein.


E. Scheufler, I. Guttmann, A. Mozes, B. Wilffert, T. Peters:

R 56865 given only during reperfusion inhibits postischemic fibrillations: schedule of drug dosage.

J. Mol. Cell. Cardiol. 23 (Suppl V), S 41, 1991

J. Schneider, E. Beck, D. De Chaffoy de Courcelles, C. Heers, B. Wilffert, T. Peters:

Cardiac effects of the highly selective phosphodiesterase type III (PDE III) inhibitor R 80122 in an acute heart failure model.

J. Mol. Cell. Cardiol. 23 (Suppl V), S 43, 1991

B. Wilffert, D. Wilhelm, D. Wermelskirchen and T. Peters:

Calcium channel modulators.



In: Receptor data for biological experiments: A guide to drug selectivity.

J.C.A. van Meel and H. N. Doods (Eds.). Ellis Horwood Ltd., 181-189, 1991

H.R. Schwietert, D. Wilhelm, B. Wilffert, P.A. van Zwieten:

Can an interaction with glibenclamide-sensitive K+-channels be associated with the contractile effect of some -adrenoceptor antagonists in the rat portal vein?

Pharm. Weekbl. Sci. Ed., H10, 1991

T. Peters, B. Wilffert, P.M. Vanhoutte and P.A. van Zwieten:

Calcium channels in the brain as targets for the calcium channel modulators used in the treatment of neurological disorders.

J. Cardiovasc. Pharmacol. 18(Suppl. 8), S1-S5, 1991

D. Wermelskirchen, B. Wilffert, U. Nebel, A. Wirth, T. Peters:

R 59494 inhibits veratridine-induced 45Ca2+ uptake in isolated rat atria in a stereospecific manner.

Wiss. Zeitschrift der Humboldt-Univ. zu Berlin, R. Medizin 40(3), 85-89, 1991

E. Scheufler, A. Mozes, B. Wilffert and T. Peters:

Inhibition of postischemic fibrillations by R 59494 optical isomers in Langendorff hearts from guinea-pigs.

Wiss. Zeitschrift der Humboldt-Universität zu Berlin, R. Medizin 40(3), 91-96, 1991

D.Wermelskirchen, J. Gleitz, J. Urenjak, B. Wilffert, F. Tegtmeier and T. Peters

Flunarizine and R 56865 suppress veratridine-induced increase in oxygen consumption and uptake of45Ca2+ in rat cortical synaptosomes.

Neuropharmacology 31, 235-241, 1992

E. Scheufler, J. Urenjak, B. Osikowska-Evers, A. Beile, I. Guttmann, B. Wilffert,

F. Tegtmeier, and T. Peters:

Ouabain-induced changes of calcium and potassium in slices of hippocampus of the rat: comparison to hypoxia and effect of R 56865.

Neuropharmacology 31, 481-486, 1992

H.R. Schwietert and B. Wilffert:

Pharmacomechanical coupling of 1-adrenoceptors in the isolated rat portal vein.

Naunyn-Schmiedeberg's Arch. Pharmacol. 345 (Suppl), R 108, 1992

B. Wilffert:

R 56865, ein neues antiischämisches Prinzip.

Deutsche Apotheker Zeitung, 132. Jahrg., Nr. 31, p 1644, 1992

D. Wermelskirchen, B. Wilffert, U. Nebel, A. Leidig, A. Wirth and T. Peters:

Veratridine activates a silent sodium channel in rat isolated aorta.

Eur. J. Pharmacol. 219, 253-259, 1992

H.R. Schwietert, M.-J. Mathy, D. Wilhelm, B. Wilffert, M. Pfaffendorf and P.A. van Zwieten:

1-adrenoceptor-mediated Ca2+-entry from the extracellular fluid and Ca2+-release from intracellularstores: no role for A,B-adrenoceptor subtypes in the pithed rat.


H.R. Schwietert, D. Wilhelm, B. Wilffert, T. Peters:

The effect of some -adrenoceptor antagonists on spontaneous myogenic activity in the rat portal vein and the putative involvement of ATP-sensitive K+ channels.

Eur. J. Pharmacol. 211, 87-95, 1992

D. Wilhelm, B. Wilffert, W.J. Janssen, A. Leidig, C. Meuter, E. Ebbert and T. Peters:

In vitro pharmacology of R 80122, a novel phosphodiesterase inhibitor.


J. Schneider, E. Beck, C. Heers, C. Conrad, D. de Chaffoy de Courcelles, B. Wilffert and

T. Peters:

Cardiac effects of R 79595 and its isomers (R 80122 and R 80123) in an acute heart failure model.



A new class of positiv inotropic agents with highly selective phosphodiesterase type III inhibitory properties.


F. Wilhelm, M. Ebbert, A. Leidig, B. Wilffert and T. Peters:

The phosphodiesterase IV inhibitor rolipram enhances mechanical and electrical effects of the phosphodiesterase III inhibitor R 80122.

Br. J. Pharmacol. 105, 284P, 1992


Veratridine-induced [45Ca2+ ] uptake as an indication of electrically silent Na + channels in isolated aorta.

Br. J. Pharmacol. 105, 103P, 1992


The contractile effect of some -adrenoceptor antagonists in the rat portal vein and the putative involvement of ATP-sensitive K+ channels.


D. Wermelskirchen, B. Wilffert and T. Peters:

Veratridine-induced intoxication: an in vitro model for the characterization of anti-

ischemic compounds?

Rev. Clin. Bas. 3, 293-321, 1992

M. Henrichs, E. Scheufler, A. Mozes and B. Wilffert:

Nicardipine inhibits postischemic fibrillation in guinea pig hearts primarily by its cardiodepressant effectduring ischemia.


K. Belsner, M. Pfeifer and B. Wilffert:

Reversed-phase high-performance liquid chromatography for evaluating the lipophilicity of pharmaceutical substances with ionization up to log Papp = 8.

J. Chromatogr. 629, 123-134, 1993

P. Hennemann, C. Achenbach, D. Wilhelm and B. Wilffert:

Na+ -Ca2+ exchange during phase I of action potential in sheep heart purkinje fibres.

Eur. J. Physiol. 422, R 104, 1993

C. Heers, J. Schneider, E. Beck and B. Wilffert:

Influence of positive inotropic agents on the regulation of cardiac output under conditions of increasingafterload in stunned myocardium.


H. Rambold, K. Riedel, D. Wilhelm, B. Wilffert and P. Honerjäger:

R 56865 blocks open and inactivated states of the cardiac sodium channel.


H.R. Schwietert, H. Batink, B. Wilffert, M. Pfaffendorf and P.A. van Zwieten:

Pharmacological analysis of 1-adrenoceptor binding sites in rat left ventricular tissue with subtype selective antagonists.

Br. J. Pharmacol.108, 139P, 1993

E. Scheufler, M. Henrichs, I. Guttmann, A. Mozes and B. Wilffert:

Effect of the Na/H exchange inhibitor ethyl-isopropyl-amiloride (EIPA) during ischemia and reperfusion.

Br. J. Pharmacol.108, 118P, 1993

D. Wilhelm, J. Schneider, D. de Chaffoy de Courcelles, R. Xhonneux, G. Vandeplassche,

F. de Clerck, B. Wilffert and T. Peters:

Pharmacology of the selective phosphodiesterase III inhibitor R 80122.

Cardiovasc. Drug Rev., 11, 12-44, 1993



U. Vollmer, B.W. Müller, J. Mesens, B. Wilffert and T. Peters:

In vivo skin pharmacokinetics of liarozole: percutaneous absorption studies with

different formulations of cyclodextrin derivatives in rats.

Int. J. Pharmaceut. 99, 51-58, 1993

E. Scheufler, C. Heers, B. Wilffert, T. Peters and G.N. Pierce:

Interference of N-(1-[4-(4-Fluorophenoxy)butyl]-piperidinyl-N-methyl-2-benzothiazol¬amine with Na+/H+ exchange and Na+/Ca2+ exchange in purified cardiac sarcolemmal membranes.

Arzneim.-Forsch./Drug Res. 43(II), 1145-1147, 1993

J. Gleitz, A. Beile, B. Wilffert and F. Tegtmeier:

Cryopreservation of freshly isolated synaptosomes prepared from the cerebral cortex

of rats.

J. Neurosc. Meth. 47, 191-197, 1993

U. Vollmer, B.W. Müller, B. Wilffert and T. Peters:

An improved model for studies on transdermal drug absorption in-vivo in rats.


J. Gleitz, A. Beile, S. Khan, B. Wilffert and F. Tegtmeier:

Anaerobic glycolysis and postanoxic recovery of respiration of rat cortical

synaptosomes are reduced by synaptosomal sodium load.

Brain Res. 611, 286-294, 1993

R. Schwietert, D. Wilhelm, B. Wilffert and P.A. van Zwieten:

Functional study on the effects of nifedipine, cromakalim, and the absence of extra-

cellular Ca2+ on 1-adrenoceptor-mediated excitation-contraction coupling in isolated

rat portal vein: comparison with depolarization-mediated excitation-contraction coupling.

J. Cardiovasc. Pharmacol. 21, 739-748,1993

U. Vollmer, B.W. Müller, J. Peeters, J. Mesens, B. Wilffert and T. Peters:

A study of the percutaneous absorption-enhancing effects of cyclodextrin

derivatives in rats.


W. Reimann, N. Selve, W. Englberger, E. Friderichs and B. Wilffert:

Spinal antinociception by morphine in rats is antagonised by galanin receptor antagonists.


Y. Xie, K. Dengler, E. Zacharias, B. Wilffert and F. Tegtmeier:

Effects of the sodium channel blocker tetrodotoxin (TTX) on cellular ion homeostasis in rat

brain subjected to complete ischemia.

Brain Res. 652, 216-224, 1994

W. Reimann, W. Englberger, E. Friderichs, N. Selve and B. Wilffert:

Spinal antinociception by morphine in rats is antagonised by galanin receptor antagonists.


E. Scheufler, A. Mozes, I. Guttmann, and B. Wilffert:

R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only

during reperfusion.

Cardiovasc. Drugs Ther. 9, 545-553, 1995

M.Ch. Frink, H.-H. Hennies, W. Englberger, M. Haurand and B. Wilffert:

Influence of tramadol on neurotransmitter systems of the rat brain.

Arzn. Forschung 46, 1029-1036, 1996

J. Schneider, S. Wnendt, D. Saunders, R. Heinzel-Wieland, B. Wilffert, and G. Steffens: Thrombin inhibitory and clot-specific fibrinolytic activities of the urokinase variant, M23 (rscu-PA-40 kDa/Hir).



Eur. J. Pharmacol. 302, 69-77, 1996

N. Selve, W. Englberger, E. Friderichs, H.-H. Hennies, W. Reimann, B. Wilffert:

Galanin receptor antagonists attenuate spinal antinociceptive effects of DAMGO, tramadol and non-opioid drugs in rats.

Brain Res. 735, 177-187, 1996

J. Friese, J. Gleitz, U.T. Gutser, J.F. Heubach, T. Matthiesen, B. Wilffert, N. Selve:

Aconitum sp. alkaloids: the modulation of voltage-dependent Na+ channels, toxicity and antinociceptive properties.

Eur. J. Pharmacol. 337, 165-174, 1997

J. Wemer, W. Tamminga, B. Oosterhuis, B. Wilffert, J.H.G. Jonkman, L. de Ley, R. de Zeeuw, R. Herings, S. Vranckx, B. Drenth and J. Meulenbelt:

Application of genetyping as a tool for optimization of pharmacotherapy. Genetyping in relation to pharmacokinetics and pharmacodynamics.

Conceptuur 14, 34-36, 1997

U.T. Gutser, J. Friese, J.F. Heubach, T. Matthiesen, N. Selve, B. Wilffert, J. Gleitz:

Mode of antinociceptive and toxic action of alkaloids of Aconitum spec.

Naunyn-Schmiedeberg’s Arch. Pharmacol. 357, 39-48, 1998

B. Wilffert, W.J. Tamminga, J. Wemer, B. Oosterhuis, J. Wieling, J.H.G. Jonkman, L.F.M.H. de Ley, R.A. de Zeeuw:

Distribution of CYP2D6 and CYP2C19 phenotypes in Dutch male and female volunteers in clinical pharmacology studies.


J. Wemer, B. Oosterhuis, B. Wilffert, J.H.G. Jonkman:

Surrogaat eindpunten in klinisch farmacologisch onderzoek.

Conceptuur 17, 4-6, 1998

W.J. Tamminga, J. Wemer, B. Oosterhuis, J. Wieling, B. Wilffert, L.F.M.H. de Leij, R.A. de Zeeuw, J.H.G. Jonkman:

CYP2D6 and CYP2C19 activity in a large sample of the Dutch population: indications for oral contraceptive-related gender differences.

Eur. J. Clin. Pharmacol. 55, 177-184, 1999

A.A. van Vliet, J. Wemer, B. Wilffert, J.W.P. de Vroedt, J.H.G. Jonkman:

Informed consent in healthy volunteers: whom does it protect?

Good Clinical Practice Journal, 6, 1, 23-26, 1999

B. Kögel, J. Schneider, J. Gleitz, B. Wilffert, Th. Peters:

Effects of AL 107, a novel semisynthetic cardiac glycoside, on the cardiovascular system in anaesthetized Beagle dogs with pentobarbital-induced cardiac insufficiency.

Arzneim.-Forsch. 49 (II), 8, 679-684, 1999

J.M.H. Conemans, A. de Boer, J.H.G. Jonkman, J. Wemer, W. Tamminga, B. Wilffert, J.R.B.J. Brouwers, D.R.A. Uges et al.:

Farmacogenetica: een nieuw vak.

Pharm. Weekbl. 134, 24, 832-837, 1999

E.N. van Roon, B. Wilffert:

COX-3-inductie als anti-inflammatoir mechanisme. De COX-paradox.

Pharm. Weekbl. 136, 38, 1422-1423, 2001

E.N. van Roon, T.L.ThA. Jansen, L.Mourad, P.M. Houtman, G.A.W. Bruyn, E.N. Griep, W.A. Baars, B. Wilffert, H. Tobi, J.R.B.J. Brouwers:

Leflunomide in active rheumatoid arthritits: A prospective study in daily practice.

Naunyn-Schmiedeberg's Arch. Pharmacol. 365, R 481a, 2002

E.N. van Roon, L. Mourad, W.A. Baars, B. Wilffert, T.L.ThA. Jansen, J.R.B.J. Brouwers:

Efficacy, tolerability and discontinuation of leflunomide in unselected outpatients with rheumatoid



arthritis.

Pharmacol. Toxicol. 89(Suppl.1) 134 (Ab 540), 2001

E.N. van Roon, A.L.M. Kerremans , S. Flikweert, W.J.M. Kwee-Zuiderwijk, M. le Comte, B. Wilffert, J.R.B.J. Brouwers, on behalf of the Working Group on Pharmacotherapy and Drug Information, WINAp, The Hague, The Netherlands:

Structured assessment of the relevance of drug-drug interactions.



Determination of the polymorphisms His452Tyr and 102T/C of 5-HT2A- and –141C Ins/Del of D2-receptors in whole-blood and buccal swabs using PCR-RFLP genotyping.


E.N. van Roon, N.A. Botta-Steeneken, T.L.Th.A. Jansen, B.Wilffert, J.R.B.J.Brouwers:

Optimization of antirheumatic leflunomide therapy by therapeutic drug monitoring.



Determination of 5-HT2aR His452Tyr, 5-HT2aR 102T/C, and DRD2 -141C Ins/Del polymorphisms in

whole-blood and buccal swabs using PCR-RFLP genotyping.

Ned. Tijdschr. Klin. Chem. Labgeneesk. 29 (2), 65, 2004

E.N. van Roon, T.L.TH.A. Jansen, L. Mourad, P.M. Houtman, E.N. Griep, B. Wilffert, H. Tobi, J.R.B.J. Brouwers:

Leflunomide in active rheumatoid arthritis: a prospective study in daily practice.

Br. J. Clin. Pharmacol. 57:6, 790-797, 2004

N.E. Ajubi, A.F.Y. Al Hadithy, J.R.B.J. Brouwers, H. Storm, B. Wilffert:

Determination of dopamine receptor (D2) -141C Ins/Del polymorphism in

whole-blood and buccal swabs by PCR-RFLP genotyping using GC-Rich® solution.

Ned. Tijdschr. Klin. Chem. Labgeneesk. 29 , 263-265, 2004

B.Wilffert, R. Zaal, J.R.B.J. Brouwers:

Pharmacogenetics as a tool in the therapy of schizophrenia.

Pharm. World Sci. 27, 20-30, 2005

E.N. van Roon, M.D. Wu, F. Idzinga, P.M.L.A. van den Bemt, T.L.Th. A. Jansen, P.M. Houtman, M.A.F.J. van de Laar, B. Wilffert, J.R.B.J. Brouwers:

A multidisciplinary approach for the assessment of drug interactions with disease-modifying antirheumatic drugs.


B.Wilffert, A.F.Y. Al Hadithy, J.R.B.J. Brouwers, K. Jangbahadoer Sing, G.E. Matroos, H.W. Hoek and P.N. van Harten:

A pharmacogenetic analysis of tardive dyskinesia in Afro-Caribbean psychiatric inpatients on long-term treatment with first generation antipsychotics.

Br.J.Clin.Pharmacol. 62:6, 738, 2006

R. Bruggeman, B.Wilffert, A.F.Y. Al Hadithy, K. Jangbahadoer Sing, G.E. Matroos, H.W. Hoek,

J. van Os, J.R.B.J. Brouwers,P.N. van Harten:

Tardive dyskinesia pharmacogenetics in Afro-Caribbean patients on neuroleptic treatment.

Am. J. Med. Gen. Part B, (Neuropsychiatric Genetics) 141B (7): 790, 2006

A.F.Y. Al Hadithy, B.Wilffert, R.E. Stewart, N.M.G. Looman, R. Bruggeman, J.R.B.J. Brouwers, G.E. Matroos, J. van Os, H.W. Hoek and P.N. van Harten:

Dopamine D2, serotonin 2A, and 2C receptor polymorphisms in Afro-Caribbean inpatients: differences in association with parkinsonism, tremor and rigidity.


M.K. Reinders, E.N. van Roon, P.M. Houtman, B. Wilffert, J.R.B.J. Brouwers, T.L.Th.A. Jansen:

Biochemical effectiveness of allopurinol monotherapy and allopurinol-probenecid combination therapy



in previously benzbromarone-treated gout patients.


A.F.Y. Al Hadithy, B. Wilffert, R. Bruggeman, J.R.B.J. Brouwers, J. van Os, K. Jangbahadoer Sing, G.E. Matroos, H.W. Hoek, P.N. van Harten:

Pharmacogenetics of tardive dyskinesia in Afro-Caribbean inpatients on neuroleptic treatment. Schizophrenia Bulletin. 33 (2): 275, 2007



Polymorphisms of dopamine D2, serotonin 2A, and 2C receptors in relation to parkinsonism,

tremor, rigidity, and badykinesia in male Afro-Caribbean patients.

Basic & Clinical Pharmacology & Toxicology. 101 (supplement 1): 80-81, 2007

B. Wilffert, A.F.Y. Al Hadithy, V. Jangbahadoer Sing, G. Matroos, H.W. Hoek, J. van Os, R.

Bruggeman, J.R.B.J. Brouwers, P.N. van Harten:

The role of dopamine D3, 5HT2A and 5HT2C receptor variants as pharmacogenetic determinants

For tardive dyskinesia in African-Caribbean patients with chronic antipsychotic

treatment. The Curaçao Extrapyramidal Syndromes Study IX.

J Psychopharmacol 23(6): 652-659, 2009 (OnlineFirst, published June 18, 2008)

B.Wilffert, R.J. Boskma, P.H.J. van der Voort, D.R.A. Uges, E.N. van Roon, J.R.B.J. Brouwers:

4-Aminopyridine (fampridine) effectively treats amlodipine poisoning: a case report.

J.Clin.Pharmacy and Ther. 32: 655-657, 2007

A.F.Y. Al Hadithy, B.Wilffert, R. Bruggeman and J.R.B.J. Brouwers:

The impact of MDR1 polymorphisms on prolactin concentrations in patients treated with risperidone.

Letter to the Editor. Prog Neuro-Psychopharmacol & Biol Psychiatry 32: 593-594, 2008

A.F.Y. Al Hadithy, B.Wilffert, R.E. Stewart, N.M. Looman, R. Bruggeman, J.R.B.J. Brouwers, G.E. Matroos, J. van Os, H.W. Hoek and P.N. van Harten:

Pharmacogenetics of Parkinsonism, rigidity, rest tremor, and bradykinesia in African-Caribbean inpatients: differences in association with dopamine and serotinin receptors. The Curaçao Extrapyramidal Syndromes Study VIII.

Am. J. Med. Gen. Part B (Neuropsychiatric Genetics) 147B: 890-897, 2008

J.J. Swen, I. Wilting, A.L. de Goede, L. Grandia, H. Mulder, D.J. Touw, A. de Boer, J.M.H.

Conemans, T.C.G. Egberts, O.H. Klungel, R. Koopmans, J. van der Weide, B.Wilffert, H.J.

Guchelaar and V.H.M. Deneer:


Clin. Pharmacol. & Ther. 83 (5): 781- 787, 2008

S.Vegter, C.Boersma, M.Rozenbaum, B.Wilffert, G.Navis and M.J.Postma:

Pharmacoeconomic evaluations of pharmacogenetic and genomic screening programmes: a systematic review on content and adherence to guidelines.

Pharmacoeconomics 26 (7): 569-587, 2008

M.Beinema, J.R.B.J.Brouwers, T.Schalekamp, B.Wilffert:

Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon.

Thromb Haemost 100: 1052-1057, 2008



No association between rs4606 SNP of the RGS2 gene and antipsychotic-induced parkinsonism,

tremor, bradykinesia and rigidity in Afro-Caribbean inpatients.

Br J Clin Pharmacol 66:5, 732, 2008

A.F.Y. Al Hadithy, B.Wilffert, R. Bruggeman, R.E. Stewart, J.R.B.J. Brouwers, G.E. Matroos, H.W. Hoek, and P.N. van Harten:

Lack of association between antipsychotic-induced Parkinsonism or its subsymptoms and rs4606



SNP of RGS2 gene in African-Caribbean inpatients: a possible role of the medication.The Curaçao Extrapyramidal Syndromes Study X.

Hum. Psychopharmacol. Clin. Exp. 24: 123-128, 2009

A.F.Y. Al Hadithy, S.A. Ivanova, P. Pechlivanoglou, A. Semke, O. Fedorenko, E. Kornetova,

L. Ryadovaya, J.R.B.J. Brouwers, B.Wilffert, R. Bruggeman, A.J. Loonen:

Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric

inpatients from Siberia.

Progr Neuro-Psychopharmacol & Biol Psych 33: 475-481, 2009

T.W. de Vries, B.L. Rottier, H. Visserman, B. Wilffert, J. Weel:

The influence of inhaled corticosteroids and spacer devices on the growth of respiratory pathogenic microorganisms.

Am J Infect Control 27: 237- 240, 2009

A.F.Y. Al Hadithy, S.A. Ivanova, P. Pechlivanoglou, A. Semke, O. Fedorenko, E.

Kornetova, L. Ryadovaya, J.R.B.J. Brouwers, B. Wilffert , R. Bruggeman, A.J.M. Loonen:

Polymorphisms of dopamine D3, serotonin 2A and 2C receptors and orofacioloingual and limb-

truncal dyskinesias in Russian psychiatric inpatients from Siberia.

Br J Clin Pharmacol: 68: 128, 2009

J.J. van Zanden, M. Lacor, B. Wilffert, P. Kingma, P.M.J. McLaughlin:

Een man met flecaïnide intoxicatie.

Ned Tijdschr Klin Chem Labgeneesk 34: 263-264, 2009

A.F.Y. Al Hadithy, S.A. Ivanova, P. Pechlivanoglou, B. Wilffert, A. Semke, O. Fedorenko, E.

Kornetova, L. Ryadovaya, J.R.B.J. Brouwers, A.J. Loonen:

Missense polymorphisms in three oxidative-stress enzymes (GSTP1, SOD2, and GPX1) and

dyskinesias in Russian psychiatric inpatients from Siberia.

Hum. Psychopharmacol. Clin. Exp. 25: 84-91, 2010

J.P. Yska,E. van Zanten, B. Wilffert:

Manufacturing study medication for clinical trials.

EJHP 15: 68-69, 2009

M.K. de Boer, D. Wiersma, J. Bous, S. Sytema, A.E.G.M. van der Moolen, B.Wilffert, T. Hamamura, H.Knegtering:

A randomized open-label comparison of the impact of aripripazole versus risperidone on sexual functioning (RAS study).

J Clin Psychopharmacology, 31(4):523-525.

A.J. Risselada, J. Vehof, R. Bruggeman, B.Wilffert, D. Cohen, A.F.Y. Al Hadithy, J. Arends, H. Mulder:

Association between the 1291-C/G polymorphism in the adrenergic -2a receptor and the metabolic syndrome.

J Clin Psychopharmacol, 30: 667-671, 2010.

J. Jentink, M.K. Bakker, C.M. Nijenhuis, B. Wilffert, L.T.W. de Jong- van den Berg:

Does folic acid use decrease the risk for spina bifida after in utero exposure to valproic acid?

Pharmacoepidemiology and Drug Safety 19: 803-807, 2010


Association between the alpha-2a-adrenergic receptor 1291C/G polymorphism and the metabolic syndrome.

Pharmaceutisch Weekbl. Wetenschap. Platform 4(6): 110, 2010

J. Vehof, A.F.Y. Al Hadithy, H. Burger , A.J. Risselada, B.Wilffert, D. Cohen, J. Arends, H. Mulder, R. Bruggeman:

Antipsychotic-induced weight gain and rs1455832 polymorphism of the ROBO1 gene: association analysis in psychosis patients on antipsychotics.

Pharmaceutisch Weekbl. Wetenschap. Platform 4(6): 112A/B, 2010





Pharmaceutisch Weekbl. Wetenschap. Platform 4(6): 112H/I, 2010

M.K. Bakker, H.E.K. de Walle, B. Wilffert, L.T.W. de Jong- Van den Berg:

Fluoxetine and infantile hypertrophic pylorus stenosis: a signal from a birth defects- drug exposure surveillance study.

Pharmacoepidemiol and Drug Safety: 19: 808-813, 2010

J. Vehof, A.F.Y. Al Hadithy, H. Burger , A.J. Risselada, B.Wilffert, D. Cohen, J. Arends, H. Mulder, R. Bruggeman:

BMI and RS1455832 SNP of the ROBO1 gene: association analysis in patients using antipsychotics.

Schiz. Res. 117(2-3): 532-533, 2010

J. Vehof , A.J. Risselada, A.F.Y. Al Hadithy, H. Burger, H. Snieder, B. Wilffert, J. Arends,

L. Wunderink, H. Knegtering, D. Wiersma, D. Cohen, H. Mulder, R. Bruggeman:

Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and

HbA1c values in patients on antipsychotic medication.

Psychopharmacology (Berl) 216:257-265, 2011.

B. Wilffert, J. Altena, L. Tijink, M.M.H.J. van Gelder, L.T.W. de Jong-van den Berg:

Pharmacogenetics of drug-induced birth defects: What is known so far?

Pharmacogenomics 12(4): 547-558, 2011

B. Wilffert , J.J. Swen, , H. Mulder, D.J. Touw, A.-H. Maitland-van der Zee, V.H.M. Deneer:

From evidence based medicine to mechanism based medicine. Reviewing the role of

pharmacogenetics.

Int. J Clin Pharm 35: 369-375, 2013. Online 33(1): 3-9, 2011




Pharmacogenetics: From bench to byte. An update of guidelines.

Clin. Pharmacol. & Ther. 2011; 89(5):662-673.

J. Vehof, A.J. Risselada, A.F.Y. Al Hadithy, H. Burger , H. Snieder, B.Wilffert, J. Arends, L. Wunderink, H. Knegtering, D. Wiersma, D. Cohen, H. Mulder, R. Bruggeman:

Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication.

Psychopharmacology(Berl) 2011;5:257-265.

J. Vehof, H. Burger, B. Alizadeh, A.F.Y. Al Hadithy, B. Wilffert, H. Snieder:

Antipsychotic treatment response in Caucasian patients: Association analysis of polymorphisms in 7 candidate genes in the GROUP study.

Schizophrenia Bulletin 37: 93, 2011



Pharmacokinetics and withdrawal reactions of clomipramine of in utero exposed neonates.

Naunyn-Schmiedeberg's Arch. Pharmacol. 383, 74, P314 2011





Pharmaceutisch Weekbl. Wetenschap. Platform 5(6), 2011

P.G.J. ter Horst, S. van der Linde, J.P. Smit, J. den Boon, R.A. van Lingen, F.G. Jansman, L.T.W.



De Jong- van den Berg, B. Wilffert:

Clomipramine concentration and withdrawal symptoms in ten neonates.

Br. J. Clin. Pharmacol 73(2): 295-302, 2011

B. Wilffert, A.J.M. Loonen:

Inleiding in lichamelijke bijwerkingen.

In: A.J.M. Loonen, J.E. Hovens, eds. Handboek Functionele Psychofarmacologie. De Tijdstroom: Utrecht, 2011:390-391.

P. van Harten, B. Wilffert:

Bewegingsstoornissen.


B. Wilffert, A.J.M. Loonen:

Cardiovasculaire bijwerkingen.


C.M.Nijenhuis, P.G.J. ter Horst, L.T.W. de Jong- van den Berg, B. Wilffert:

Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1: Literature review.

Br. J. Clin. Pharmacol. 73(1): 16-26, 2012

C.M.Nijenhuis, P.G.J. ter Horst, L.T.W. de Jong- van den Berg, B. Wilffert:

Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 2: Testing the hypotheses.

Br. J. Clin. Pharmacol. 73(1): 126-134, 2012

J. P. Koning, J. Vehof, A.J. Risselada, H. Burger , B.Wilffert, A.F.Y. Al Hadithy, B. Alizadeh, P.N. van Harten, H. Snieder,Genetic Risk and Outcome in Psychosis (GROUP) invetsigators:

Association of two DRD2 gene polymorphisms with acute and tardive antipsychotic-induced movement disorders in young Caucasian patients.

Psychopharmacology 219:727-736, 2012.

S.A. Ivanova, A.J. M. Loonen, P. Pechlivanoglou, M.B. Freidin, A.F.Y. Al Hadithy, E.V. Rudikov,

I.A. Zhukova, N.V. Govorin, V.A. Sorokina, O.Y. Fedorenko, A.V. Semke, J.R.B.J. Brouwers,

B. Wilffert:

NMDA receptor genotypes associated with the vulnerability to develop dyskinesia.

Transl. Psychiatry 2, e67, 2012



Pharmacogenomics Journal, 12(1):62-67, 2012

P.G.J. ter Horst, J.H. Bos, L.T.W. de Jong- van den Berg, B. Wilffert:

In utero exposure to antidepressants and the use of drugs for pulmonary diseases in children.

Eur. J. Clin. Pharmacol 2013 69(3):541-7, published online 20 July 2012

S.A. Ivanova, A.F.Y. Al Hadithy, N. Brazovskaya, A.V. Semke, B. Wilffert, O.Y. Fedorenko,

J.R.B.J. Brouwers, A.J. M. Loonen:

No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric

inpatients from Siberia.

Hum. Psychopharmacol. Clin. 27(3):334-337, 2012.

F.M. van Hasselt, Y. Coehorst, B.Wilffert, A.J. M. Loonen:

Influencing CYP enzymes to boost psychiatric treatment: a review on clinical evidence.

Pharmacopsychiatry Published online October 4, 2012




De associatie tussen HTR2C-polymorfismen en de prevalentie van het metabool syndroom bij patiënten die antipsychotica gebruiken: een replicatiestudie.

Pharmaceutisch Weekbl. Wetenschap. Platform 6(11):190-194, 2012

J. Vehof, H. Burger, B.Wilffert, A.F.Y. Al Hadithy, B. Alizadeh, H. Snieder (GROUP Investigators):

Clinical response to antipsychotic drug treatment: Association study of polymorphisms in six candidategenes.

Eur. Neuropsychopharmacology 22(9): 625-631, 2012

Hoang Thi Kim Huyen, B. Wilffert:

Chapter 1. Clinical Pharmacokinetics. In: Hoàng Thị Kim Huyền, JRBJ Brouwers. (Eds.)

Handbook of Clinical Pharmacy (in two volumes). DƯỢC LÂM SÀNG NHỮNG NGUYÊN LÝ

CƠ BẢN VÀ SỬ DỤNG THUỐC TRONG ĐIỀU TRỊ, 2012: 13- 36

B.Wilffert:

Proteomics voor schatting nierschade bij diabetici.

Pharmaceutisch. Weekbl. Wetenschap. Platform 7(1): e1305, 2013

W. Knol, R. van Marum, P.A.F. Jansen, E. Strengman, A.F.Y. Al Hadithy, B.Wilffert, A.F.

Schobben, R.A. Ophoff, T.C. Egberts: :

Genetic variation and the risk of haloperidol related parkinsonism in elderly patients: a candidate

gene approach.

J. Clin. Psychopharmacol. 33(3): 405-410, 2013

J.P. Yska, S. van der Linde, V.V. Tapper, J.A. Apers, M. Emous, E.R. Totté, B. Wilffert, E.N. van

Roon:

Influence of bariatric surgery on the use and pharmacokinetics of some major drug classes.

Obesity Surgery 23(6): 819-825, 2013

B.Wilffert:

Ongeschikte medicatie bij ouderen opsporen met Nederlandse versie STOPP en START.

Pharmaceutisch Weekbl. Wetenschap. Platform 7(2): e1304, 2013

D. Bertholee, P.G.J. ter Horst, M.L. Hijmering, A.J. Spanjersberg, W. Hospes, B. Wilffert:

Blood concentrations of cefuroxime in cardiopulmonary bypass surgery.

Int. J. Clin. Pharm. 35(5):798-804, 2013


Grote rol apotheker bij depressieve zwangere.

Pharmaceutisch Weekbl. 148(34): 18-20, 2013

N. Alsaad, B. Wilffert, R. van Altena, W.C. de Lange, T.S. van der Werf, J.G. Kosterink, J.W.

Alffenaar:

Potential antimicrobial agents for the treatment of MDR-TB.

Eur. Respir. J. 43(3): 884-897, 2014


Antidepressiva tijdens de zwangerschap en het gebruik van luchtwegmedicatie door de nakomelingen.

Pharmaceutisch Weekbl. Wetenschap. Platform 7(9):102-107, 2013

E.J.J.Berm, A.J. Risselada, H.Mulder, E.Hak, B.Wilffert:

Letter to the Editor: Phenoconversion of cytochrome P450 2D6: The need for identifying the

intermediate metabolizer genotype.

J. Clin. Psychiatry 74: 10, 2013

B.Wilffert:

Afwegingen en besluitvorming door toelatingsautoriteiten.

Pharmaceutisch Weekbl. Wetenschap. Platform 7: e1335, 2013

B.Wilffert:



LPA-polymorfisme karakteriseert hartpatiënten die kwetsbaar zijn ondanks statines.


S.A. Ivanova, L.M. Geers, A.F.Y. Al Hadithy, P. Pechlivanoglou, A.V. Semke, N.M. Vyalova,

E.V. Rudikov, O.Y. Fedorenko, B. Wilffert, N.A. Bokhan, J.R.B.J. Brouwers, A.J. M. Loonen:

Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia.

Prog Neuropsychopharmacol Biol Psychiatry. 50: 172-177, 2014

E.J.J. Berm, E. Brummel-Mulder, J. Paardekooper, E. Hak, B. Wilffert, J.G. Maring:

Determination of venlafaxine and O-desmethylvenlafaxine in dried blood spots for TDM

purposes, using LC-MS/MS.

Anal. Bioanal. Chem. 406: 2349-2353, 2014

M.J. Bijlsma, B.E. Oortgiesen, R.H.J. Beernink, J. Bos, B. Wilffert, E. Hak:

Het effect van de CBG-waarschuwing op de trend in SSRI-gebruik in Nederland van 1998 tot

2010.

Pharmaceutisch. Weekbl. Wetenschap. Platform 8(2): 32-26, 2014

B. Wilffert, J.J. Swen, H. Mulder, R.H.N. van Schaik, M.Nijenhuis, L.Grandia, A.H. Maitland-Van

der Zee, G.A. Rongen, T. Schalekamp, J. van der Weide, A. de Boer, H.-J. Guchelaar, D.J. Touw,

V.H.M Deneer:

Chapter 22. Implementation of Pharmacogenetics in Evidence-Based Medicine: Toward

Advancing Personalized Medicine

In: Handbook of personalized medicine. Advances in Nanotechnology, Drug Delivery, and Theory

Edited by Ioannis S. Vizirianakis. Pan Stanford Publishing, 2014: 953-1116

J.P. Yska, D.H. van der Meer, W. Eilander, A.R. Dreijer, J.A. Apers, M. Emous, E.R. Totté, B.


Influence of bariatric surgery on the use of some major drug classes.

Naunyn-Schmiedeberg's Arch. Pharmacol. 387 (Suppl. 1): S22, 2014

A.N.A. Daud, J.E.H. Bergman, M.K. Bakker, H. Wang, H.E.K. de Walle, T. Plösch, B.

Wilffert:

Pharmacogenetics of drug-induced birth defects: the role of polymorphisms of placental

transporter proteins.

Pharmacogenomics 15(7): 1029-1041, 2014

A.J.M. Loonen, B.Wilffert:

Beter: functionele indicatie vermelden op recept.

Pharmaceutisch Weekbl. 149 (17): 22-24, 2014

B.Wilffert:

Alternatieve geneesmiddelen, een factor van belang bij chemotherapie.


B.Wilffert:

Naar een duurzaam systeem voor geneesmiddelontwikkeling.


D.H. van der Meer, A. Wieringa, I. Wegner, B.Wilffert, P.G. ter Horst:

Lactation studies of anticonvulsants: A quality review.

Br. J. Clin. Pharmacol. 79(4):558-565, 2014

B.Wilffert:

De apotheker, geneesmiddeldeskundige bij uitstek.


B.Wilffert:

De apotheker, geneesmiddeldeskundige bij uitstek.




D.Setiawan, J. Luttjeboer, T.A. Westra, J.C. Wilschut, A.A. Suwantika, T. Daemen, J. Atthorbari,

B.Wilffert, M.J. Postma:

The cost-effectiveness of HPV vaccination in addition to screening: a Dutch perspective.

Expert Rev Vaccines. 14(4):589-604, 2015

D.A. Perwitasari, J. Atthorbari, B. Wilffert:

Pharmacogenetics of isoniazid-induced hepatotoxicity.

Drug Metab Rev . 47(2): 222-228, 2015

E.J.J. Berm, E. Hak, M. Postma, M. Boshuisen, L. Breuning, J.R.B.J. Brouwers, T. Dhondt, P.A.F.

Jansen, R.M. Kok, J.G. Maring, R. van Marum, H. Mulder, R.C. Oude Voshaar, A.J. Risselada, H. Venema, L. Vleugel, B. Wilffert:

Effects and cost-effectiveness of pharmacogenetic screening for CYP2D6 among older adults

starting therapy with nortriptyline or venlafaxine: study protocol for a pragmatic randomized

controlled trial (CYSCEtrial).

Trials 16: 37, 2015

E.J.J. Berm, R.M. Kok, E. Hak, B. Wilffert:

Relation between genotype, phenotype and therapeutic drug concentrations of nortriptyline or

venlafaxine users in old age psychiatry.

Naunyn-Schmiedeberg’s Arch Pharmacol, 388, 1: 52-53, 2015

E. van Doorn, E. Hak, B. Wilffert:

National differences in requirements for ethical and competent authority approval for a

multinational vaccine trial under the EU directive 2001/20EC

Vaccines, 3: 263-292, 2015

A.N.A. Daud, J.E.H. Bergman, M. K. Bakker, H. Wang, W. S. Kerstjens-Frederikse, H.E.K. de

Walle, H. Groen, J.H.J. Bos, E. Hak, B. Wilffert:

P-glycoprotein-mediated drug interactions in pregnancy and the changes in the risk of congenital

anomalies: a case-reference study.

Drug Safety, 38(7):651-659, 2015

A.-F. van der Paardt, B. Wilffert, O.W. Akkerman, W.C.M. de Lange, D. van Soolingen, B. Sinha,

T.S. van der Werf, J.G.W. Kosterink, J.-W.C. Alffenaar:

Evaluation of macrolides for possible use against multidrug-resistant Mycobacterium

tuberculosis.

Eur Respir J, 46(2): 444-455, 2015

B.Wilffert:

Driejaars-therapietrouw aan inhalatiemedicatie bij COPD.


B.Wilffert:

Scholing voor ict-ondersteund geneesmiddelmanagement.


E.J.J. Berm, R. Ruijsbroek, A.J.M.Loonen, K.R. Goethals, B.Wilffert, F. van Hasselt:

Overstap op e-sigaret beïnvloedt medicijnconcentratie.

Ned Tijdschr Geneesk, 159: A9090, 2015

D.P. Martono, R. Lub, H.J. Lambers Heerspink, E. Hak, B. Wilffert, P. Denig:

Predictors of response in initial users of metformin and sulphonylurea derivatives: a systematic

review.

Diabet Med. 2015 Jul;32(7):853-64.

E.J.J. Berm, J. Paardekooper, E. Brummel-Mulder, E. Hak, B. Wilffert, J.G. Maring:



A simple dried blood spot method for therapeutic drug monitoring of the tricyclic antidepressants amitryptiline, nortriptyline, imipramine, clomiramine, and their active metabolites using LC-

MS/MS.

Talanta 134: 165-172, 2015

J.P. Yska, E.N. van Roon, A. de Boer, H.G.M. Leufkens, B.Wilffert, L.J.M. de Heide, F. de Vries,

A. Lalmohamed:

Remission of type 2 Diabetes Mellitius in patients after different types of bariatric surgery. A

population-based cohort study in the United Kingdom.

JAMA Surg. Published online September 30, 2015.

P.G.J. ter Horst, J.H. Proost, J.P. SmitL. M.T. Vries, T.W. de Jong- van den Berg, B. Wilffert:

Pharmacokinetics of clomipramine during pregnancy.

Eur J Clin Pharmacol published online 29 September 2015

B.Wilffert:

Geneesmiddeldeskundige zorgverleners.


J.P. Yska, D.H. van der Meer, A.R. Dreijer, W. Eilander, J.A. Apers, M. Emous, E.R.E. Totté,

B.Wilffert, E.N. van Roon:

Influence of bariatric surgery on the use of medication.

Eur J Clin Pharmacol, 72: 203-209, 2016

E.J.J. Berm, M. de Looff, B. Wilffert, C. Boersma, L. Annemans, S. Vegter, J.F.M. van Boven,

M.J. Postma:

Economic evaluations of pharmacogenetics and pharmacogenomics screening tests: A systematic

review. Second update of the literature.

PLOS ONE January 11: 1-22, 2016

E.J.J. Berm, B. Odigie, M.J. Bijlsma, B. Wilffert, D.J. Touw, J.G. Maring:

A clinical validation study for application of DBS in therapeutic drug monitoring of

antidepressants.

Bioanalysis, published online 19 February 2016

Y.H. Tran, J. Bergman, M. Bakker, H. Groen, B. Wilffert:

Oxidative-stress-mediated teratogenesis and the role of folate

Naunyn-Schmiedeberg's Arch. Pharmacol. 389 (Issue 1): S14, 2016

S.A. Ivanova, O.Y. Fedorenko, M.B. Freidin, V.A. Alifirova, N.G. Zhukova, I.A. Zhukova,

A.F.Y. Al Hadithy, J.R.B.J. Brouwers, B. Wilffert, A.J. M. Loonen:

Dissimilar mechnistic background of peripheral and orofacial hyperkinesia in patients with

Parkinson’s disease and levo-dopa-induced dyskinesia.

Physiol. Pharmacol. 19: 216-221, 2016

M.A. Zuur, M.S. Bolhuis, R. Anthony, A. den Hertog, T. van der Laan, B.Wilffert, W. de Lange, D.

van Soolingen, J.-W.C. Alffenaar:

Current status and opportunities for therapeutic drug monitoring in the treatment of tuberculosis.

Expert Opinion on Drug Metabolism & Toxicology 2016 in press

B.Wilffert:

Dosering nadroparine bij nachtelijke hemodialyse.

Nederlands Platform voor Farmaceutisch Onderzoek 1: e1609, 2016

S.A. Ivanova, A.J. M. Loonen, P.R. Bakker, M.B. Freidin, N.J. ter Woerds, A.F.Y. Al Hadithy,

A.V. Semke, O.Y. Fedorenko, J.R.B.J. Brouwers, NJ.A. Bokhan, J. van os, P.N. van Harten, B.

Wilffert, :

Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic



receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient

populations.

SAGE Open Medicine 4: 1-9, 2016

E. Berm, R. Kok, E. Hak, B. Wilffert:

Relation between CYP2D6 genotype, phenotype and therapeutic drug concentrations among

nortriptyline and venlafaxine users in old age psychiatry.

Pharmacopsychiatry Published online: 2016

J.P. Yska, S. Gertsen, M.Emous, B.Wilffert, E.N. van Roon:

NSAID use after bariatric surgery: a randomized controlled intervention study.

Obes Surg 26: 2880-2885, 2016

B.Wilffert:

Toxiciteit van fluoropyrimidines bij drie varianten van dihydropyrimidinedehydrogenase.

Nederlands Platform voor Farmaceutisch Onderzoek 1: e1610, 2016

A.N.A. Daud, J.E.H. Bergman, W. S. Kerstjens-Frederikse, H. Groen, B. Wilffert:

The risk of congenital heart anomalies following prenatal exposure to serotonin reuptake

inhibitors- Is pharmacogenetics the key?

Int. J. Mol. Sci., 17, 1333(1-20), 2016

D.P. Martono, E. Hak, H.J. Lambers Heerspink, B. Wilffert, P. Denig:

Predictors of HbA1c levels in initial users of metformin.

Current Medical Research and Opinion. Published online 23 Aug 2016.

H.Hummels, D. Bertholee, D. van der Meer, J.P. Smit, B.Wilffert, P. ter Horst:

The quality of lactation studies including antipsychotics.

Eur. J. Clin. Pharm. Published online: 24 Aug 2016

S.A. Ivanova, D.Z. Osmanova, M.B. Freidin, O.Y. Fedorenko, A.S. Boiko, I.V. Pozhidaev, A.V.

Semke, N.A. Bokhan, A.A. Agarkov,B. Wilffert, A.J. M. Loonen:

Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating

hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia.

World J. of Biol Psychiatry. Published online 22 Sept 2016

S.A. Ivanova, D.Z. Osmanova, A.S. Boiko, , I.V. Pozhidaev, M.B. Freidin, O.Y. Fedorenko, A.V.

Semke, N.A. Bokhan, E.G. Kornetova, L.D. Rakhmazova, B. Wilffert, A.J. M. Loonen:

Prolactin gene polymorphism (-1149 G/T) is associated with hyperprolactinemia in

patients with schizophrenia treated with antipsychotics.

Schizophrenia Res online 21 Oct 2016

E. J.J. Berm, J. J. Gout-Zwart, J. Luttjeboer, B. Wilffert, M. J. Postma:

Analysis of Routine Genotyping for CYP2D6 among Older Depressed Inpatients Starting Nortriptyline

Pharmacotherapy.

PLOS ONE 11(12):e0169065, 2016

Y.H. Tran, H. Groen, J.E.H. Bergman, E. Hak, B. Wilffert:

Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of

psychotropic medications among children.

Pharmacoepidemiology and Drug Safety, Published online 2017

P.H.J. van der Voort, B.Wilffert, E.N. van Roon, D.R.A. Uges :

4-Aminopyridine as a life-saving treatment in calcium channel antagonist intoxication.

Neth. J. Med. 74, 6: 276, 2016

Projects



Memberships

Other Relevant Information ADDENDUM

H-index: 29

LEHRVERZEICHNIS

Co-promotor (zuständig für die tägliche Betreuung eines Doktoranden) bei Doktoranden von Prof.Dr. P.A. van Zwieten an der Universität von Amsterdam:

H.W.G.M. Boddeke: New aspects of calcium antagonists and their effect upon ischaemia (Promotionsdatum 18. Mai, 1988).

M.A.M. Gouw: Pharmacological characterization of the calcium sources contributing to contractions of various isolated blood vessels (Promotionsdatum 15. November, 1989).

H.R. Schwietert: Alpha-1 adrenoceptors in vascular smooth muscle: Promiscuous or heterogeneous? (Promotionsdatum 7. Dezember, 1992).

Tägliche Betreuung von Doktoranden in Deutschland:

Peter Koch: Untersuchung vaskulärer Kontraktionsprozesse in vitro und in vivo unter Berücksichtigung von N-[4-(4-Fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2-benzothiazolamin (R56865) und Strukturanaloga (20. Februar, 1990, Prof.Dr.Dr. E. Mutschler, Johann Wolfgang Goethe-Universität, Frankfurt am Main).

Ulrike Vollmer: Einfluss von Cyclodextrinen auf die transdermale Absorption (1992, Prof.Dr. B.W. Müller, Christian-Albrechts-Universität, Kiel).

Detlef Wermelskirchen: Untersuchung der Veratridin-induzierten 45Ca2+ Aufnahme in verschiedenen Geweben der Ratte (1993, Prof.Dr.rer.nat. H.-H. Borchert, Humboldt-Universität, Berlin).

Unvergüteter Lehrauftrag im Umfang einer Wochenstunde im Fachbereich Biochemie, Pharmazie und Lebensmittelchemie an der Johann Wolfgang Goethe-Universität in Frankfurt am Main (SS 1988-WS 1988/89-WS 1989/90).

Thema:

Spezielle Pharmakologie des sympathischen Nervensystems (für Doktoranden).

Habilitation im Fach Pharmakologie (Habilitationsschrift: The pharmacological analysis of contractile processes of cardiac and vascular smooth muscle under physiological and pathophysiological conditions-a study with agents interacting with calcium) an der Johann Wolfgang Goethe-Universität inFrankfurt am Main (18. Januar 1993) und seitdem unvergüteter Lehrauftrag als Privatdozent im Umfang einer Wochenstunde.

Themen:

Analgetika, Lokalanästhetika, Hypnotika

Therapie der Herzinsuffizienz und der koronaren Herzkrankheit

(Beides im Rahmen des Pharmakologisch-toxikologischen Demonstrationskursus und des Kursus der Physiologie).

In 1999 Umhabilitation zur Rheinischen Friedrich-Wilhelms-Universität und seitdem unvergüteter Lehrauftrag als Privatdozent im Umfang einer Wochenstunde.

Themen:

Pharmakologie in der pharmazeutischen Industrie. Arbeitsweise des Pharmakologen in der Arzneimittelentwicklung illustriert an Fallbeispielen.

“Qualitätsmanagement” in der pharmakologischen Forschung

Im weiterbildenden Studiengang “Master of Drug Regulatory Affairs”: Good Clinical Practice, Ethics in Clinical Research, Clinical Pharmacology I and II, Clinical Trial Guidelines I

Betreuung Doktorand am Universitair Centrum Farmacie der Rijksuniversiteit Groningen (Mitglied der Begleitkommision)

W.J. Tamminga: Polymorphic drug metabolising enzymes: Assessment of activities by phenotyping and genotyping in clinical pharmacology. (Promotionsdatum 18. Juni, 2001).

In 2001 Visiting Senior Researcher (unvergütet) in the Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy of the Rijksuniversiteit Groningen.

Co-promotor von A.F.Y. Al Hadithy: Pharmacogenetics of antipsychotic-Induced Parkinsonism and Tardive Dyskinesia: a Focus on African-Caribbeans and Slavonic Caucasians.(2009)



Co-promotor von M.J. Beinema: The optimization of coumarin anticoagulant therapy: Pharmacogenetics and computer assisted dose finding. (2009)

In 2011 Professor Pharmacotherapy and Clinical Pharmacy in the Rijksuniversiteit Groningen and the Universitair Medisch Centrum Groningen:

Promotor von P.G.J. ter Horst: Clinical Pharmacology of Antidepressants during Pregnancy (2013)

Promotor von E.J.J. Berm: Optimizing treatment with psychotropic agents through precision drug therapy. It is not about the mean (2016)


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