PersonnelPlacement |

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SCENCE133 HSwow E OO

POSITIONS WANTED

Analycl ei Bi ist, MS.: Experience incli oicology, dr sceing, chemical warfareagents. Pepide and proten rmsrch. Box 64, SCIENCE.

Bies Tecnolo B.S., ResarchAoe,1981. Sevecny o e (ttsearch, industry)in a varity of bio enym i SA imuno-k%icl asy, which i l2adbiso~ tcch!-Tqc,, jaap ,rpy mc8em7actm-tm,varx okxmtkus ax for loan'g, quama-taio prons and car s. Purification d -

aainof plxroi, gd

filtraion, ion-xchag, chmatographdCAMKphoresis ani sdee ICr84. Al; rocombnam mbae mcbrn pf batia cukie.Excellent skills. Sesks a dic/iia ormedical laboratory speaking Engh in Canada. Box 38,SCIENCE.

Celular Eay t/Tco0logist, M.D, Ph.D.with rcet etsive ivol in the deveopmnt ofnew technologies for in vitro drug toxicity and sensitivitytesting, propnetor of several possibe patents, seeksSenior Researc Scietst position and patts pro -

tion inphama industry, medical scls or otherapprpriate search institns. Box 57, SCIENCE.

Cyuoeneticit, Ph.D. Dircs fill-service medical cyto-genetics aboy; exnsive experine in human andmammlian CytKsogenetic tu-morcyp cs, chrmoso and DNA damage. Seeksion in research and medical yto c laboratory.

B 58, SCIENCE.

Imm olIst/Genetist Ph.D. Hybridoma, immu-noassay, cel cu recombinnt DNA experience.Seeking posn in New York City, New Jersey, Penn-

ylania. Box 62, SCIENCE.

Immunologist, Ph.D. Eperienced lesearcher and proj-ect manager with backgrouid in hyidom, onoo-nal bo s, cancer imuology, pes, andlarge-scale tiss culu. Seeking iblepoonindeveloment of immunothera c aches to hu-man disease. Box 63, SC3I .

Ph.D. in nutitim (1986). Two years of postdoctexperience. Rsearch expeience in molecar biology,enymology mand onp fit ion.Sor industry resrch o nits. Box 54, g.INCE.

Sientific Data Anlysis andPr Semi-relat-ed Ph.D. (physiobgy), with over 30 years of experiencedeveloping and rm bo utine and novelanalysis meths; anyLowrrates for inteetng projcts. Box S CZNE

POSITIONS OPEN

Ihe Dqement of Anatomn of the University ofKansas Medical Center is seeking a tmure-track AS-SISTANT PROFESSOR for 1 July 1988. Barequired is a Ph.D. and/or M.D. dee, and at least 2years ofpost ience in clular, devopmn-tal, or nnbogy. Teaching resWosibilites are teach-ing hcad and nc to edical sdn. Thc successfulcandidate will dnionse potenal to develop an inde-n t research program in onc of the above areas.

Salary and secd money arc neabl. Send curriculumvitac, several recent reprints, and ltters from threcrefernces to: Robert M2K, Ph.D D a t ofAnatomy, Univeity ofKan Medil r, 39thd Rainbow B vard, Kanas City, KS 66103.Thm Unieny ofKans Medicl Ceter a an Equa

Op uy/AjirmatiwAaiox Emplyer.

ASSISrANT PROFESSOR INMOLECULAR ENDOCRINOLOGY

The Center for Endocriology, Metabolism, and Nu-trtion (CEMN) of Northwestern Universit M lSdcool inimts appikations for a tenur-tack position inmolecular endocrinol at the assistan p ekvelin the appropriate clinil or basic sce depaCEMN Is an interdisciplinary unit enco ngffiom the Departns of Medicne, Pediatris, Obstet-rics and Gynelgy, Cell Biolog, Phamacology, andMolecular Biology. The succeiful candidate ias anM.D.-Ph.D., Ph.., or M.D. degree with postdoctoralexperience in contmporar molcular biology, molcu-lar genetis or cll biolo. The candidate is exeed todevote the majort oftime to laboratory studies toconduct an ifunded researbch program inthe areas of hmone o reation of hormonesynthesis/secrton, geintic exession of hormones andhormone-regulated protens, trans-menbrane signalingor rlated aspects of mammalian ndocri .Abroad-based approach to the molecr aspect o;hor-mone physioloy is prefrred. Scnd cricul vitae, adescripton of research interests and three letters ofrecmmenatiOn directly to: Gerhard Buman,MD

airman. Search Committee, Centr for Endocri-nolog, Metaboism, and N ion NrdthwesternUniversity Medical Sool, 303 East Chica A-nue, Chicago, IL 6061. Nortweter is anEqual 0pporns&yL4ffiaiAon Em yr.

ASSISTANT RESEARCH ENDOCRINOLO-GIST, Deprmt of Medicine, University of Califor-nia, San Francisco: Ph.D. (biochemistry), sceralyears ofpostdotoral experince. Join research procct on mecua-nism by whidc cakium, vitain D and PTH regulatedi ntat of normal and transfomed nocytes.Expacne required iin protan dy,stryy

RzHPLC, cultuae- preerd in acokhrmones. Salary: $36,600. Send curriclum vitae to: D. D.Be, M.D, Ph.D, VA Medial Center (111N),4150 aCment Street, San F C, A 94121.Equa 0pWrunily Elokyer.ASSISTANT RESEARCH ENDOCRINOLO-

GIST position availble in endorinology and metabo-lism. (cvd of appointmnt equivalent to assistant pro-fessor.) Ph.D. in moeclr biology/io s or rele-vant biologicals3ciences. Minimum of2 years ofpostdc-toral eperience in molcular bioloy, expertse intechniqus of molecular coning, in vitro mutenesis,trasfctoand expreion ofcDNA in eukaryotc cells,and protein biochemistry. Research will focus on mokc-ular mechni of insulin acton. Salary establishedwithin University of f Srnia5an Diego sahnr .cak.Reply to: J odM. Olefy, M.D., by l July 1988 at:Uniersity ofCalifrni San Diego,D ofMedicine, M-023E, La Jolh, CA 9209.AJ aeiAaioEqual Oprnxity Explyer.

ASSISrANT SCIENTIST-for multidiscplinarydrug delivery resrch program. Individual will be re-sponsibk for develping innovative medtods to improvethe delivery of peptides and proteins. Applicants musthavc a Ph.D. degre in the pham cal sciences orequivaknts, proven xpse in isolating hpatocytes,conducting liver perfion studics and analying expen-mcntal data by modclin mcthds Por.t ahourspdr $25,000 to(' f8,500 per year.Sendcurri1um vitae with names and addresses ofthrecrenes to: Dr. R ald T. Borchardt, De ofPhama cal hemistry, he U Kanas,Lawrence, KS 66045. Deadline for appcons: 15 M"ay1988. Ax EqualOFyJiatinE .

ASSISTANT/ASSOCIATE PROFESSOROF IMMUNOLOGY

TUFTS UNIVERSrTY MEDICAL SCHOOLTcnure-track position in the Pathogy Deparment

for individual with strong, fd ch rcord incellular/molecular immunoloy or immAppointee cxpected to prcipate in teaching of proes-sional and graduate stu s.

Applicants should send a summary of research inter-csts, curricuhln vitac, and three letters of recommenda-tion to: Dr. Sidney Leowitz, Tufts Medical School,136 Harrison Avenue, Boston, MA 02111.Tus* Uxoeity is an Equal Oppotuty Emplyer.

ASSISTANT/ASSOCIAIE PROFESSOROF NEUROPATHOLOGY

UNIVERV1TY OF MINNESOTADEPARTMENT OF LABORATORYMEDICINE AND PATHOLOGY

Faculy posion available inmneuropatoogy at rank ofasstnt or asocit professor, denng on qualifica-tions. Applicant will be ecd to head a vigorousresearc proeam in neurobiolog. Minimum requiire-ments are M.D., BC/BE in anatomic pathology andncuropathology subspecaty with 2 years (assistnt pro-fessor) or 5 years (associate proessor) of experience inneuropathology or neuroscuences. Demonsated re-search productivity necesary inclding publications inpeer-rmewed joumals. Teaching inclui fellows inneuropathol gay,- pathology, medical felowsfrom other services, and medical stdents. Assist inproviding neuropatogy services to patients at Univer-sity HsiaPnvi curiculum vitae, three kete ofreommenda-

tion, and a brief synopss ofrecent resarh actvities to:N _ ~ Search mitteL

D q dIaboatqMedcn andPaykUniverty ofMinn BOX 198 UMHC

420 Delawre Street SEM el MN 55455

Dadlinemfor recipt ofapplications is 15 August 1988.Te U riy ofM a Eq i

Edcator and E r aaa a d .

SCIENCE, VOL. 240

POSITIONS WANTED

554-

POSITIONS OPEN

ScientLsts

Genentech, Inc., a leader in the field of biotech-nology, is currently seeking the followingindividuals.

ScientistRetrovirus Studies

An individual is sought to participate in state-of-the-art research on endogenous and exogenouseAmirses of mammalian cell lines.The successful candidate will have a Ph.D. andpostdoctoral research in the molecular biology ofretroviruses with experience in recombinant DNAtechniques.

Postdoctoral FellowCell Biology

An individual is sought to pursue a project dealingwith the effects of growth factors on gonadal/pitui-tary cells and the Wgulation of secretion of suchfactors in the male reproductive system or otheraspects of growth factor function.Requirements include a Ph.D. and 1-2 year post-

doctoral experience in endocrine physiology,reproductive biology or mode of action of growthfactors. Cell culture and/or basic cell biology skillsare also required.Genentech, Inc. offers an excellent salary and ben-efits package coupled with the opportunity tomake a sigufficant contribution to our organiza-tion. For consideration, send yur resume to JoyceGoulden, Human Resources, Genentech, Inc., 460Point San Bruno Blvd., South San Francisco, CA94080. Please indicate Department 1464 for theScientist position and Department 2149 for thePostdoc. An equal opportunity employer.

((Ramamma9 o0n(3o

Genentech, Inc.OwnnuokOn0

PROTEIN

CHEMISTOtsuka Pharmaceutical Co., Ltd., MarylandResearch Laboratories, a branch of one of Japan'smajor pharmaceutical companies, currently has aprofessional opening for an experienced ProteinChemist.You will lead the Protein Purification Group in thepurification of high molecular weight peptides,amino acid analysis, and two dimensional gel elec-trophoresis. The successful candidate will hold aPh.D. and 5-7 years of relevant experience.Otsuka offers competitive salaries, an excellentbenefits package and an opportunity to advanceyour career with a dynamic, progressive organiza-tion dedicated to innovative research. Qualified ap-plicants should send a C.V. with salary history re-quirements to: Scientific Recruitment

~ Otsuka Pharmaceutical Co., Ltd.

Qy(H)0CO Maryland Research LaboratoriesRO0. Box 4165

Rockville, MD 20850

"Otsuka people creating new productsfor better health worldwide."An Equal Opportunity Employer

TODAY'SINNOVATION...TOMOROW'SSUCCESSIn the highlycompetitive, high volumeHBA categories of suncare, footcare,and proprietary medicines, Schering-Plough's Personal Care Products suchas COPPERTONE, DR. SCHOLL, and DI-GEL have always maintained aprominent market position. To assureourcontinued leadershiproleand sup-port growth in new product development activities, we are seeking candi-dates for the following positions:

ANALYTICAL SKIN RESEARCHPrincipal Scientist-Responsible for providing analytical support to SkinBiology research p.rogram geared toward OTC product development. Re-quires a Ph.D. in Pharmacology, Toxicology, or other life sciences and atleast 1 year experience with GC, GC-MS, NMR, TLC electrophoresis, andrelated techniques. Related experience may be substituted for education.

PHOTOAGING RESEARCHSenior Scientist-Responsible for investigation of radiation effects on theskin. Requires a Ph.D. in Life Sciences, Pharmacology, or PhysicalChemistry.Chemist-Responsible for assisting in investigation of radiation effects onthe skin. Requiresa B.S. in Biochemistry or Chemistry and two years relat-ed experience.MELANOGENESIS RESEARCHChemist-Responsiblefor assistingin investigation of melanogenesis asrelated to skin coloration. Requires a B.S. in Chemistry or Biochemistry andtwo years experience with tissue eulture techniques.

PHARMACEUTICAL RESEARCHScientist-Responsible for scale-up of tablets and gums, development ofinnovative processes. Requires a B.S in Chemistry or Pharmacyand4 yearssolid-dosage process experience.We are a Fortune 200Company, headquartered in an attractive sunbelt lo-cation. We offer highly competitive compensation and benefit programs, in-cluding profit sharing and scientific incentive awards. We also offer aprogressive research environment characterized by dedication to innova-tion and continued industry leadership. For prompt consideration, pleasesend your resume with current salary in confidence to:

r Schering-Plough CorporationP.O. Box 377-PCG, Attn: Ann SchaffMemphis, TN 38151An Equal Opportunity Employer M/F/HIV

I -1

POSITIONS OPEN

ASSISTANT PROFESSOR OF PHYSIOLOGYThe Department of Physiology is seeking candidates

for a faculty (12-month, tenure-track) position at theassistant professor level. The Department has an orienta-tion in the area ofcardiopulmonary physiology. We seekan individual whose research interests relIte to themicrocirculation or vascular endothelial cell function, butencourage applications from individuals in other areas ofcardiovascular or pulmonary physiology as well. Re-quirements include Ph.D. or M.D., completion of 2years of postdoctoral training, a sound background ingeneral physiology, and the ability to develop ownresearch program. Will be responsible for teaching gas-trointestinal and portions ofcardiovascular physiology inthe medical physiology course. Opportunties exist forcollaborative research and participation in graduate edu-cation. Submit curriculum vitae, statemcent of researchinterests, and names of three references by 16 May 1988to: Dr. Michael B. Maron, c/o he Office of HumanResources, Northeasten Ohio Universities Collegeof Medicine, Rootstown, OH 44272. An AffimttiAction/Equal Opprtunity Employer.ASSISTANTORASSOCIATE PROFESSOR OF

MEDICINE to assume major scientific responsibilityfor a cardiovascular molecular biology program. Thecandidate may be an M.D. or Ph.D. with interest andexperience in molecular genetics of contractile proteinsmembrane channels or membrane receptors. The candi-date would be expected to establish own laboratory andinteract closely with active ongoing laboratories workingin biochemistry, cell physiology, and cell biology of thecardiovascular system within a research-oriented Sectionof Cardiology. Please send inquiries, r6sumi, and thenames of three refcrcnces to: Morton F. Arnsdorf,M.D., Chief, Section of Cardiolog, Univity ofChicago Hospitals, Box #423, 51 South Mary-land, Chicago, IL 60637.

ASSOCIATE IN PAIN MANAGEMENTOREGON HEALTH SCIENCES

UNIVERSITY SCHOOL OF MEDICINEThe Department of Anesthesiology at the Oregon

Hcalth Sciences University School ofMedicine is recruit-ing for a full-time faculty member at the assistant profes-sor level. The successful recmiit will have an academicappointment in the School of Medicine, and will haveteaching and research responsibilities in the Pain Man-agement Center of our University Hospital. Candidatesshould have specific training (at least 3 months) in painmanagement and rclated research and should have expe-riencc in a multidisciplinary pain management center.Candidates should have an aptitude for research, demon-strated by primary authorship of peer-reviewed publica-tions in the field of pain management and/or regionalanesthesia. Ability to interact with basic and cdinicalscientists should be shown. Candidates should be certi-fied by the American Board of Anesthesiology and havean Oregon medical license. Salary will be $34,000 baseper year, with overage from practice plan earnings.Interested candidates should send their curriculum vitaeand the names of three references to: Wendell C.Stevens, MD., Professor and Chairman, DepartmentofAnesthesiology, Oregon Health Sciences Universi-ty, Pordand, OR 97201.

ASSOCIATE RESEARCH SCIENTIST. Positionavailable immediately. Ph.D. with training in inflamma-tory mediators or cellular immunology to participate inongoing research on host responses to injuy/infection.Salary range: $30,000 to $35,000, based on experience.U.S. actizen orpermanent raidenc required. Send curricu-lum vitae and names of three refcrences to: Dr. AnnBjornson, Director, Division of Immunolog, JamesN. Gambk Institute of Medical Resarch, 2141 Au-burn Avenue, Cincinnati OH 45219. Affirmative Ac-tionlEqual Opportunity Employr.

BIOCHEMIST, ASSISTANT PROFESSOR, 1-year position with possibility of renewal starting fall1988. Duties: supervision of biochemistry program,teaching courses in biochemistry and molecular genetics,directing undergraduate research. Good research facili-ties. Ph.D. and teaching experience prefrred. Applica-tions will be received until position is illed. Send resume,research plans, unofficial transcripts, and have hreeletters of reference forwarded to: Biochemistry SearchCommittee, Dow Science Building, Alma College,Alma, MI 48801.

BIOMEDICAL ENGINEERPosition open in the Orthopedic Research Depart-

ment, Motion Analysis Laboratory of Children's Hospi-tal and Health Center, San Diego. Qualifications: Ph.D.or equivalent degree in engineering, biomechanics, com-putng, or related field. Significant experience in gaitanalysis, grant procurement, administration, and teach-ing. The candidate will be eligible for an academicappointment at the Univcrsity of California, San Diego.Send curriculum vitae and cover letter to: HumanResources Department, Children's Hospital, 8001Frost Street, San Diego, CA 92123. EquaLO ntEnmployr.

BOTANIST-Tenure-track assistant professorshipwith teaching responsibilities induding general botany,upper level plant ecology, and graduate courses in theapntee's area. Preference wil[ be given to applicants

to coordinate Biology Education program. Re-search opportunities indude modern laboratory, herbari-um, and a 1000-acre canpus nature preserve. Sendcurriculum vitae and three letters of reference by 20 May1988 to: Dr. Paul Hamilton, Chairr Depart-ment of Bioklgy, The Univrsity ot West Florida,Pensacola, FL 32514. Equal O nt/Af aAton Instiiuion.

Thc Department ofMicrobiology and Immunology atthe University of Miami School of Medicine seeks aCELLULAR IMMUNOLOGIST interested and dedi-cated to the study of immunological tolerance. We seekan investigator skilled in in vitro cellular immunologicalassays, lymphocyte cloning, and tissue culture. Intcrestedapplicants should send a letter, curriculum vitae, andnames of three references to:

J. Wayne Streilein, M.D.Professor and Chairman

De tment of Microbiology and ImmunologyUniversity of Miami School of Medicine

P.O. Box 016960 (R-138)Miami, FL 33101

CELLULAR IMMUNOLOGISTS-TENURE TRACK

The Trudeau Institute invites applications for two,full-time, tenurc-track positions at the level of assistantprofessor or associate professor. The successful applicantswill be provided the mcans to develop independentresearch programs dealing with some aspect ofthe role ofaccessory cells, lymphokines, or monokines in regulatingimmune responses. Training in molecular immunology isdesirable, but not essential. Candidates wis to studyother problems in cellular immunology will also beconsidered. Existing research programs at the institutedeal with immune responses to ineious agents, intra-cellular parasites, tumors, and allografts.The Trudeau Institute is a free-standing, not-for-profit

pure research institute attractively located in a modemcomplex on the shore of Saranac Lake, 10 miles fromLake Placid, New York. Compensation indudes liberalfringe benefits. On-campus housing is available.

Send resume and the names of three references to:Dr. Robert J. North, Director

Trudeau InstituteP.O. Box 59

Saranac Lake, NY 12983

COMPUTATIONAL NEUROSCIENCE-AT&T BELL LABORATORIES

Position available for an EXPERIMENTAL NEU-ROSCIENTIST working at the cellular and systemslevel. The successful candidate is expected to establish avigorous and independent researchprogram. Both seniorinvestigators and postdoctoral researchers with severalyears of experience are appropriate candidates. Bcll Labo-ratories has a strong commitment to fundamental experi-mental and theoretical research in computational neuro-science. Send rnsume, publications list, brief outline ofproposed research, and names of three refcrences to: L.W. Jelinski, Department Head, Molecular BiophysicsResearch Depatment, AT&T Bell Laboratories, 600Mountain Avenue, Murray Hill, NJ 07974.

CHAIRPERSON: Department of Meteorology,University ofMaryland, Colege Park, Maryland. Nomi-nations and applications are invited. The Departmentconsists of 12 faculty mcmbers, 4 research scientists, 15research associates, and 45 graduate students. About tenoff-campus research scientists from NOAA and NASAparticipate in collaborative research projects. The candi-date should possess a doctorate degree and a record ofexcellence in scholarly achievements. Responsibilities in-dude administration of the graduate teaching and re-search activities ofthe Department and the chairperson isexpected to provide imaginative leadership and enhancethe role of the Department in the emerging national andinternational earth sciences programs. Applicants shouldsubmit curriculum vitae and the names offour referencesto: Dr. N. S. Chant, Chairman, Meteorology SearchCommittee, Departent of Physic, University ofMaryland, College Park, MD 20742. Please submitapplications as soon as possible; applications will beaccepted until the position is filled. The Uniert ofMaryland is an Equa Op ntAffi Action Em-ployer. Women and i s are encouraged toapply.

CHEMISTS AND BIOCHEMISTSA variety of opportunities for B.S., M.S. and Ph.D.'s

with some of the most exciting companies in the U.S.,both well-established and start-ups going to production.If you have expertise in biotechnology, immunology,molecular biology, pharmaceuticals, preformulation,QA/QC, analytical, HPLC, GC/MS or the environmen-tal fielid, Lybrook Associates is your best source for abetter job. Employer retained. To learn more, call:Karen Lybrook at 401-683-6990, or send your resu-me: Lybrook Assodates, P.O. Box 572, Ncwport, RI02840.

Start up, biotechnology company, central New Jerseyarea is seeking a recent Ph.D. CHEMIST/BIOCHEM-IST with expertise in DNA chemistry, for working in thearea of novel DNA probe assay development. Competi-tive salary benefits and a possible equity position areavailable. Send resume to: P.O. Box 4338, Metuchen,NJ 08840.

DEPARTMENT HEAD:VIROLOGY/aMMUNOLOGY,

ASSOCIATE/FULL PROFESSORThe Primate Research Institute (PRI) ofNew Mexico

State University (NMSU) is seeking a department headfor its Virology/Immunology Department. Qualifica-tions include: Ph.D., D.V.M., or M.D. with provenexperience and leadership in retroviral research. Salary:$60,000 to $90,000, depending upon experience andqualifications.The successful candidate will lead a rapidly expanding

research effort in retroviral diseases and hepatitis. PRIpresently has a $2-million annual research program inAIDS and hepatitis vaccine development in chimpanzees,as well as a bic therapeutic and vaccine research pro-gram in the simian immunodeficiency model. PRI has anew excellently equipped 4000-square-foot P-3 labora-tory, and several biocontainment animal housing mod-ules. PRI also has a colony of 2000 macaques and 440chimpanzees available for research. The successful candi-date will be expected to lead a new department to anoutstanding program in virology and immunology withemphasis on vaccine and therapeutic development forAIDS. Resources are available for additional seniorpositions. The salary is highly competitive in New Mexi-co's low cost-of-living environment. PRI employs 140people working in toxicology, virology, reproductivebiology, metabolism, surgery, and primatology. TheInstitute is located 50 miles from the main NMSUcampus in the high desert, and 10 miles from Alamogor-do and the Sacramento Mountains. Employees maychoose living conditions varying from desert to alpine.

Benefits indude: Group medical and hospital insur-ance, group life insurance, long-term disability insurance,annual and sick leave, and state educational retirement.NMSU is an Equal Employment Opportunity/AffimatieAction Employer. Ofer of emplyment is contient uonverificin of individual's dlqbiy of emplo nt in theUnited States.Submit curriculum vitae and names of three references

to: William C. Hobson, Director, Primate ResearchInstitute, P.O. Box 1027, Holloman AFB, NM88330-1027. Deadline for application is 20 June 1988.

SCIENCE, VOL. 240556

POSITIONS OPEN POSITIONS OPEN

TheDiagnosticImaging

division of our Medical Productsdepartment has a unique opportu-nity for an exceptional individualto manage the pharmacologysection of our R&D group.

The ideal candidate will have aP.h.D. in Pharmacology or arelated discipline with demon-strated ability in managing state-of-the-art research programs andsupervising a highly creative pro-fessional staff.

Responsibilities include directingthe group in programs related tothe development ofnewradiopharmaceuticals. Dutiesinclude the development of ani-mal models, imaging proceduresand other pharmacological, bio-chemical and toxicological meth-ods for the selection and evalua-tion ofnew product candidates.

To apply, please send resume toErin Moore, DuPont, 331 TrebleCove Road, North Billerica, MA01862. An Equal OpportunityEmployer.

.EG US PATSkTMA

IlRESEARCH SCIENTISTS

RHONE POULENC RESEARCH CENTER is seeking scientists in theareas of bioengineering and biochemistry. Rhone Poulenc Research Cen-ter isa leader in the area of immobilized enzymes and cell technology withcommercial processes for the production of specialty chemicals andagricultural and pharmaceutical intermediates.

We have a number of openings for persons with diversified backgrounds.We are searching for biochemists withTinterests in enzyme and whole cellimmobilization, biosynthetic pathways and enzyme isolation. Applicantsshould have a Ph.D. or equivalent research experience.Bioengineering candidates should have a masters or higher inbiochemical engineering with emphasis in fermentation or enzymeimmobilization. Scale-up experience is desirable.

Rhone Poulenc Research Center is a subsidiary of Rhone Poulenc SA,a major pharmaceutical and chemical producer The research center islocated midway between Baltimore and Washington in an attractive subur-ban setting with access to all major academic, cultural and recreationalactivities within 30 minutes' drive. RPRC functions as a multidisciplinaryacademic environment with commercial goals, where science is carriedout in extremely well equipped labs, furnished with the latest instrumen-tation and with an absolute minimum of bureaucracy. Our salary struc-ture and benefits are extremely competitive. We invite qualified applicantsto submit their resumes with references to Maria Williams, Rhone PoulencResearch Center, 8510 Corridor Road, Savage, Maryland 20763. EOE.

(tRHONE-POULENC

CIBA-GEIGY is currently expanding its efforts in the area of Arthritis Researchand seeks two key individuals to provide scientific and managerial leadership forits Inflammation/Osteoarthritis Research Program.Manager, Osteoarthritis Research, Dept. 346We are seeking a Senior Scientist with a PhD in Biochemistry, Pharmacology orPhysiology with 5 years' post-doctoral experience in cartilage metabolism/osteoarthritis research. This scientist will be responsible for devising appropriatetherapeutic approaches for the treatment of osteoarthritis. This will involve themanagement of a multi-disciplinary research team of biochemists, cell biologistsand pharmacologists in collaboration with medicinal chemists in the search foreffective drugs with novel mechanisms of action. Applicants should havedemonstrated an ability to develop a competitive research program and to super-vise a research group.Manager, Inflammation Pharmacology, Dept. 344We are seeking a Senior Scientist with a PhD in Pharmacology, Biochemistry orImmunology with 5 years' post-doctoral research experience in the in vivo evalua-tion of anti-inflammatory and anti-arthritis drugs. This scientist will be responsi-ble for the design and implementation of pharmacologic models for drug evalua-tion and should have experience in the ex vivo measurements of biochemicalparameters as part of the characterization of these in vivo models. The applicantwill be expected to take an active leadership role in the overall management ofthe Inflammation Research Program and should have demonstrated the abilityto supervise a research group.For consideration, please submit, in confidence, resume, salary requirements, posi-tion of interest and appropriate department number, to: Staffing Center,CIBA-GEIGY Corporation, The Pharmaceuticals Division, 556 Morris Avenue,Summit, NJ 07901. We are an equal opportunity employer mi/f/h/v.

Science Serving Mankind

CIBA-GEIGY

University of California, DavisCELLULAR NEUROBIOLOGY

TRAINING PROGRAMFunding is avaiable to support qualified indi-

viduals for training in cellular neurobidogy atboth postdoctoral and predocoral levels. Suc-cessful applicants will join a young, vigorousneurobiology group that is highly interactiveand in which collaboratons are common. Weparticularly encourage participation of traineesin projects invotving the expertise of two ormore training faculty:

Hilary Andron, Development of insect ner-vous systems

Richard Carlsn, Cell biology of axonal andmuscle regeneration

Leo Chalupa, Prenatal development of mam-malian visual system

Carol Erickson, Morphogenesis and differen-tiation of neural crest

Mark McNmn", Molecular biology of AChreceptors

Brian Mulloney, Generaton and moduationof motor patterns

Paewb Pappone, Biophysics of ion channelsRobert Scobey, Retinal physiologySBry Wilson, Cholinesterases and neurotoxi-

clogyMrtIn Wison, Cell biology of the retina

For more information, contact Dr. Brian Mul-loney, Director, Cellular Neurobiology TrainingProgram, Department of Zoology, University ofCalifomia, Davis, CA 95616, or phone

(916) 752-746&UCD Is an Equal Opportunity/Affirmative AcIon Institution.

PharmacologyGroup Leader

POSITIONS OPEN

DIRECIOR, clinical rearch, to supervise overallplanning ofworld-wide clinical Lesearch program; directand coordinate the design, implmenation, monitoring,evaluation and reporting of ical trials; obtain ade-quate data on the safey and Efficacy of alocated com-pounds to support regitration dossiers; ensure all clini-cal resch activities comply with all local, national andinternational regulato; preparc budgets of clinicalresearch s foral cd ompo pes ocllaborate w directors and senior vIxce iol-mcdical research regarding ovcrall budgets ansafnfor clinical resarch d armt; ensure and facilitateinteractons between clm cal group and otherroups. Nopnt care. Applicant must possess a degre m medicine

harmacct l medicneor a Ph.D. dep in phamma-co6ZY as wdl as possess 3 years of expenence in the joboff red or 3 years of expeince as a medical advisor for.clinical research and medical affairs. The requircd experi-ence must have boen in the pharm utcal mdustry, andmust have incuded the pannit,initiation and compk-tion of international clinical studies valuatirng the safetyand efficacy of drugs affectg the cardivascu systnsuch as diuretics, anti-an-inalagents and anti-arrhythmicagents. Applicant with M.D. deree must have complt-ed four courses in pharm cil medicine or have beenawarded a diploma in pham cal medidne. Fortyhours per week; Monday through Friday,8 am. to 4:30p.m.; $98,000 peryear. Send r.5sume and Sodal Securitynumber to: Illinos Departmnt of EplmOnt SC-aurKq, 401 SouthState Streeth Souh, C , IL60665. A"ention: Mr. Robert Pdt,rence # V-IL 8025-F. An Employcr Paid Ad.

DIRECTORDIVISION OF TOXICOLOGY

DEPARTMENT OF PHARMACOLOGYAND TOXCICOLOGY

UNIVERSlTY OF ARKANSAS FORMEDICAL SCINCES

Ihe Deparm of Pharmacology and Toxicology ofdie University of Arkansas for Medical Sciences is con-ducng a search to ideni1r candidates for the position ofDirector of the Division of Toxicology. A successfulcadidate will have an camrd doctoral degre with actieresearch interests in pharmacology, toxicology, or occu-pational medicine.The Director of the Division of Toxicology will be

responsible for administering graduate prams in toi-cology and industrial hygiene. Othereuaioa respon-sibilities include continun education in toxcoobgy forhealth professionals.The director is expected to have and maintain an active

research program and should have de abilityto compete succesfiuy for research support

The Uxsvnay of Arka is anEmplyer. Women and moyan asto applySubmit curriculum vitae, summary of research and

administrative experience, and the names of at kast throereferecs to:

Dr. Donald R. MattisoofObttricsad Gynecology

Unni q o£kans for Medical Sciences4301 West Markham, Slot 518

Little Rock, AR 72206

ECOLOGIST/ASSISTANT PROFESSORAn entry-level, tenure-track position to begin August,

1988. Ph.D. in zoology or appropriate biological disci-pline is required Teaching responsibilities wil includeeclogy and mammal , and upper level courses inareas of spedalt. The d t ofan active researchprogranm, nd dcin ofgraduate sunts is expected.Resac area is open, but pence will be given toapplicants with expertse in ter ial and animal ecolo-gy. The successful applicant will have the oppo ity toerct with the Muray State University (MSU) Han-ok Biologicl Station and the Commonwealth CenterofExcellenc for Reservoir Research. Application reviewwill begin 1 May 1988 and continue until position isfilled. Submit transcript(s), three letters ofrecommenda-tion, and uriculum vite to: Dr. Tom J. Timmons,Deartment of Biolo l SdcnCes, Mumy Staeuniversit, Murray, KY 42071. MSU is an EqualOqppeuisylinnatieAaimon Emplye.

POSITIONS OPEN

ENVIRONMNTAL CONSULTANT for engi-neeing firm in southwest Ohio to munage, conduct, and

e environmental studies and impact assessnts,water quality and land use assessments, environmentalpl.anig, demogaph profiks and baseline sudicm,perform computer modehdn and ecological field charac-terizations; analye Interactive and geogra computer

develop environmentalx remt sensing process-csSo lients. Must have a B.S. and an M.S., one degree

in biobyorenv u scieces and the oter inurban pcnng al planning, ty and regonalplanning or nvintal planing; and 1 year ofexpeience in all duties ofjob descibed. Forty hours perweek, 8 am. to 5 p.m. $28,000 per year. Qpalifiedapplicantsrepbyimmediatelywithrdstim6to: R. TLechr,JU#023o, Obo Bu ofEmplbmn Ser-

ices, P.O. Doe 1618, Columbus, OH 43216.

EVOLUTIONARY BIOLOGISTSThe National Zoolgic Park, Smitdsonian Institu-

tion, is soeking two evoutionary biologists, a seniorscientist-in-dhrge and rsearch s.cntist idatesmust bc interested in conservation biology, and capableof using mokcular techni towards th analysis of

genetics and sociobiological probens inhi ebratv s (especially birds an-d mammals). Both

candidates should have active research programs anddemonstrated research productivity. Additional duties ofthe senior position include overseeing the zoo's molocu-lar gics unit,m a molear cs labora-tory, and supervising unor staff, echdcians, researchflows, and students. Succssfil candidates for bothpositions will be expected to devlop independent re-searc prgrams, and nderte collabotive researchwith zoo staff whose inteests inchide the genetics ofnatural and wild populations, population mana t,physiology, behavil ecoogy, and socibiol.gSalatics and grad levels will bcomesrt cduca-ton and/or experience, and are lkely to rangc from GS-12 to GS-15.

Start-up and operating funds for the laboratory areexpected, but the successfl es will be expectedo geerate grant funds to support sone ofthe research.Applications must include an SF-171 (Personal Qualifi-cations Statement), collegeupiversit transcpts, curric-ulum vitae, descption of rLeh and career goals,abstracts ofyour three most significan publiations, andnames and addresses of three rrences; and shoud beaddressed to: Smi an Instituton EmOffice, 900 Jefso Driv, S.W, Wa gton D.C.20560. A scepate anplication is r(j for each posi-tion. Deadlinc is 6 May1988. However, seection maybe effected the dosing datc. Addrss timques to:Dr. D. G. tlein National Zoologkal Park Wash-ington, D.C. 20008. Teb Smitsosian Ins*ution a anEqual n E yr apl ion V- an eml caniae anai.

UNIVERSITY OF PENNSYLVANIASCHOOL OF MEDICINE

DIVISION OF LABORATORY MEDICINEDEPARTMENT OF PATHOLOGY AND

LABORATORY MEDICINEThe Depar of Patholog and Laboratoty Medi-

ane has FACULTY OP GS in the areas ofhema-tolgy, clinical dcmistry, blood banking, and microbiol-ogy. The individuals must possess an M.D. and/or Ph.D.degree and be Board-certiledin the area of specdality.

Candidates must have demonstratd academi researchskills and vce q uc and have generated orpossess the ability to generate ennal f ing for teirresearch Academic rank and salary will be comme tewith experience and qualifications. The Uneeny ofPennsylania an Equal OpponmiyLjinmativ AcionEmployr.

Inquiries and curriculum vitae with names of dtreereferees should bc sent to:

Donald Young, MD., Ph.D.Diector

Divion of Laboraor MedineDepartmnt of Patholop and Laboratoy Medicine

Hospital oftde Uniersy o Penns l3400 Spruce Sret

Pliidlhil PA 19104-4283

POSITIONS OPEN

ENVIRONMENTAL SCIENCESOne tenurc appoinm , A ISAN PRO-

FESSOR, wili be mae in eithr: (i) aquatic virology/microbioogical publc health or (ii) phtpankton/nu-trient cycling. To become part of an i splinardepartment of natural and social scientiss w ng pn-marily in coastal/estuarine systems. Ph.D.iredot-doctorl experiene prferred. Ihe c candatewill be expected to nuintain an extramural findedresarch am, teach n direct graduate students,and estblish a sbg pbicaon ror and e insignificant rofessional service. Send raumn-ia coverletter by I3 1988 to:

Ofiiqot M _ at Boston, Bon,0%215. An AfieAti AonEqxt Opporenity/Titl IX Enskyjr.

The Eppey Institute for Research in Cancer, Universi-tyofNebrasa Meda Center, invits applications for atenure-trac FACULTY POSITON. Responsibilitieswill incude superv of the Ins s AAALACaccredited animal facilit whic houses rodents. Candi-dates must have a D.V.. from an accredited school ofveeinay medicine, Board cetiica by ACLAM orelibility for certficai and be censedmi th state ofNebraska. The sucssfil applicant will be cxpected toconduct a research program either in an area related tocancer biology or carci is, or in another area ofbiomedical science. Please ond to positon #8-6669.Applicants should send a letter and curriculum vitae to:Dr. Edward Bresnick, Director, Eppley Inste forResac in Cancer andAidDisae, Uniest ofNebraska Medical Center, 42nd anDe Ave ,Omaha, NE 68105.

FACULTYPOSMON (X-RAY CRYSrALLOG-RAPHY) program in protcin stuctr and design,University of Mihigan. Applications are invted for atenured or tenure-track position (rank open) associatedwith the Progam in Protein Strucure and Design. Theacadmic appointment will be in the Departnt ofBiological Chemistry, with a joint appointment in theBiophysics Rcsearch Division. We seek an individualwho will interact with and complemen the existingstructure p ineth Prram, and who will develop astrongin re progaminthe high rsou-tion is of biolo$ical macromolecules. Existing facil-ities for x-ray diaon inchxde an area detector syem,interacive owuter graphics, and a variety of othrcomputational aies, among them the UM IBM3090. Opporities are availabk for a broad range ofdepartmental and disciplinary collaborations. Inter-ested candidates should seid, by 15 June 1988 if possi-be, curiculum vitae documenting qualifications, pr-sional accomplishments, and future researh plans, togher with names and add of three refeAnces, to:Dr. Mar L. Iaib Bb IeiihDIXwo,University ot MidXn, 2B00 Bkvad,Ann Arbor, MI ql . The UnmivnyofMicfan is anEqual OpAcaion Empkyfr.

FACULTY POSMONS, cell and molecular physi-ology. The Derment of l The University ofWLsconsin, Madison, i pcaons for tenure-track, junior and seor level fanlty positions in cdlularand molecular physiologyh.The deparm especallyencourages applications frm individuals with feereinterests and regulay or developmental aspect ofcellular and subehalar fuinction, but will gve seiousConsideration to outstading aplications in o areas.The search will favor i whose resarch enailsthe use ofbiochmical biophysical, or molecular biologi-cal probes ofphysioloc relvant processes. Excellentopportimitics cxist for pticipation i campus-widc in-irysarch and waDmng prms. Tesc

postins il beavilable aficr I July 1-989.W om adminonha ar s ea cowm ed to apl.

Applicants shold send curriculum vitae, asummary ofresearch interests and plans, and the names of threerfrnces to: Dr. Richard L. Moss, Chair, Depart-m ontPhof lo1 U nirof WI 1300

Uniy A Madan, t 53706. The Uxbn-ty OfWicnsin a an Equal OpplpxnyL4fiw&astieAaionEmplyer.

SCIENCE, VOL. 240

NEUROBIOLOGY/RESEARCH ON

PAIN MECHANISMS

ONE RESEARCH STAFF POSMON

is now available at the Clinical ResearchInsitute of Montreal.Candidates able todevelop independent research projectson PAIN MECHANISMS are primorilysought. The condidate will be indepen-dent director of research laboratory andable to interact with existing groups inmoleculor biolagy/neurobiology. Perti-nent and adequate postdotoral for-motion is required. Position is at facultylevel with no teaching responsibilitiesbut with university affiliotion for supervi-sion of graduate students.

Application with CV and names of ref-erees should be forwarded to:

Dr. Mkhel Chrien, Scientfic Dior,ainiccl Research InstItne of Montreal110 Pine Avenue West,MONTREAL, (Quebec), CanadaH2W 1 R7(514) 842-1481

In accordance with Canadian immigro-tion requirements, priority will be givento Canodion citizens and permanentresidents of Canoda; however, othersare strongly encouroged to apply.

DO YOU THINK

DNA SEQUENCING

IS AN ART?Do you appreciate the visual delight of a well resolved sequencing ladder andthe power of the clear information obtained? We at Amgen do, and weappreciate even more the vital role our Research Associates in DNASequencing play in our pioneering work in Biotechnology. Without theirsupport we would not be the industry leader in recombinant DNA technologywe are today.We're looking for more Research Associates to help us produce even morebreakthroughs in the human pharmaceutical, human diagnostic, animalhealth care and specialty chemical areas. If you possess a B.S. or M.S. inBiochemistry, Molecular Biology or a related discipline, 1-2 years ofexperience in DNA sequencing, and want the kind of career opportunity,visibility and responsibility that only a rapidly growing company like Amgencan offer, we'd like to hear from you.

We offer an excellent compensation and benefits package, a spaciouscountry setting in the scenic Conejo Valley (about an hour's drive northwest ofLos Angeles), and a stimulating scientific environment. Submit your resume,in confidence, to:

Fecruitment, Dept. #96AMGEN1900 Oak Terrace LaneThousand OaksCA 91320Equal Opportunity Employer

RESEARCHSCIENTIST

At MIT's Biology Department,w ill lead research efforts study-ing capsid assembly in bacte-rial viruses. Requires Ph.D. inPhysical Biochemistry with 2-3years' postdoctoral experi-ence, publications in refereedbiochemical journals and ex-pertise in application of lightscattering, circular dichroismand ultracentrifugation to pro-tein polymerization reactions.Familiarity with growth of boc-teria and bacteriophage andmicrobial genetics would bean advantage. Supervisory ex-perience preferred. MIT is anon-smoking environment.Send CV and names of threereferences to Mr. KennethHewlift, MIT Personnel Offlce,400 Main Street, (Bldg.E19-239), Cambridge, MA02139. Reference Job No.RS.047.

MIT Is an affirmative actionlequal opportunity employer.

'RESENTUNIVERrVY CORPORATION

FOR Al_lS REReH (UCAR)

The University Corporation for Atmkosph6ri Research, a 57-university nonprofit con-sortium, is seeking a President. UCAR, created in 1959 in response to universityneeds for service, leadership and advocacy for the atmospheric and relatedsciences, operates two national centers-the National Center for Atmospheric Re-search and the Institute for Naval Oceanography-and other programs in serviceto the scientific community.Duties of the President include: formulating objectives, strategies, policies and pro-grams for Board consideration; effectively executing programs; ensuring that UCARplays a leadership role to articulate and satisfy national research needs in the at-mospheric and related sciences; promoting the interests of themember universitiesand community; establishing and enforcing the highest standards of scientific andmanagement excellence; obtaining adequate resources to pursue the goals of theCorporation.Qualifications include: highest-quality scientific and management leadership abilityand knowledge of the atmospheric or related sciences; demonstrated skills as aneffective negotiatorand advocate; experience in planning and managing large-scaleresearch activities and/or sizable research institutions; and broad acquaintancewith the university research community, policy-making bodies, and the private sector.Activities of the President require extensive travel, including a significant fractionof time in Washington, D.C. Place of residence and other aspects of the positionare a matter of hegotiation with the UCAR Trustees.The successful applicant is expected to be appointed no later than 1 September1988. Applicants should send a letter of interest, a curriculum vitae and a list of pub-lications so as to be received by 15 June 1988 to:

[r. WifNm L Gordon, ChairmanUCARPresident SearChCommittee -PO Box 3000, Boulder, CO80307

Nominations are also welcome.Further information is available from Ms. Dianne Bernier, (303) 497-1655.

UCAR is an equal opportunity, affirmative action employer.

POSITIONS OPEN

FACULTY POSTIMONSA center for Gcn Stucure and Function has boen

establishedby the RCMI progam o the NH andHunter CollgIbee Department ofBiolgicl Scienimates appik for tenure-trpi os a all profesorial for its ding program in that areaThe d eartinptis l imri candidaeswith

rsaci mtrsts in i mgy ad/or no1clancs but dtoi other areasifeaotcel/neurobiology are alo encoura$ed to app. Appoin-tees are expcted to establish an researchprogramad to p i t c e inther areas of e rise at the und aute and/or

-lute Send cr m fie researchintePrets, and names Of three refere o:

Profesor Hrvey L 0OueofmeintOfaB l sden

Hnte _ CiUnity sy ofNew York695 Par Ae

New York, NY 10021AnxE vd isAm E$rjw.~~~~~~arfe --I lo-ppdt p*.

FRSHEBJES MANAGEMENT TEACHINGRB-SEAICH POSION. Tenurem-ack, 12-month, be-

faill 1988 at asistant vel Ph.D.

quired. Sixtq perct in; i s in

ion nmics and or un-

dergraduates and a atecours in a me a. The

candi is expe ted deveop a fisheries rsarch

proga in in wi

resource Sed r um

on tea ig sad resarch goals, rep e rerts,

and three Of referece ay 1988 ot: Dr.

John L. Jones,Chi, S4oo1 of

FPrest7, PWbcries and Wdfie, University of Mis-

oun, mbia, MO 65211.Ax A JrExAErOp E

FULL PROFESSOR. OF ECOLOGYUNIVESTY OP GENEVA

Th Dqpmn ofAtrpolgfi 1 ekapicants for a post of Zr or ewbgy.

Tscig(in Fruc) invl a bask courselaoapym g as weias

courses i ecology. Q d h ain biology (or the an

bitologand fieldexeenceineco~~~~2pWl be antp

curriculumc, a sof rcearch interests and names of three refebefoe 30 June 1988 to:

SecrEtriat de FPacl des Science

20, qusi Ernest-Ansrmet1211 Genbve 4gw~dand

IIE A M DIRECTORL: We seek a sysIsetst-rvi a and curatrial eprince with anogKms tosrvas Dirctor of the Univesity of Kansas

erbarinm,hold anassistant or aiat p or position in the Dep ofBotany rearc andteac se evotibona biolog. Pr will be

D ths having istrative ce andor ahistoy ofexternl grant suppot Ihc posin is tenure-t or tenure, and the slary is e with

Position aailable as of 1 January 1989.Applicants should asubit (i) a clum vite, (i) a

of research goals and cuaoria/adminrcexperiencO(iii)d tn of u that the applicc o would like to teach, (iv) acies of prints and/oir m (v) CM of oceCn& fiM at kast tbrepcrsom ob b_ybthdc datc, 30 let1988,:aSiHnDSrD_w of Dom" Ud

of Kansas, 6604. T UniwitfKmm isanE n p.wusff.A#pkctcoare f_J V J

wvv U,50o &cesy.

560

AMERICAN ASSOCIATION OF PATHOLOGISTS, INC.and

UNIVERSITIES ASSOCIATED FOR RESEARCH AND EDUCATION INPATHOLOGY, INC.

EXECUTIVE OFFICERBiomedical research association (AAP) and

consortium of university medical schools (UAREP) invitenominations and applications for a joint appointment

AAP responsibilites include: Management of a 2500-member professionalassociation, a corporate society of the 30,000-member Federation of AmericanSocieties for Experimental Biology (FASEB), that promotes the scientific ad-vancement and dissemination of knowledge with respect to the field of ex-perimental pathology; the society sponsors scientific meetings and educationaland training activities, publishes a quarterly newsletter as well as The Ameri-can Journal of Pathology, and participates fully in the activities of FASEBRUAREP responsibilities include: Administration of grants and contracts for

member universities; coordination of the editorial preparation of the Atlas ofThmor Pathology; organization of teaching and research conferences co-sponsored with member universities; coordination of development, production,and distribution of teaching monographs in pathology; negotiation and execu-tion of contracts for studies of contemporary issues in occupational and en-vironmental pathology and toxicology.

Position requires seasoned administrator with established record of scientificand management excellence. Applicants should submit curriculum vitae, per-sonal bibliography, and summary of applicable management and administra-tive experience to David Korn or Robert Anderson, c/o AAP, 9650 RockvillePike, Bethesda, MD 20814. Anticipated start summer/fall 1988.

aU ~_uwww~~murnmmww

VIRAL IMMUNOLOGISTThe Upjohn Company, a leader in worldwide research manufacturng and marketing ofpharmaceuticals, chemicals and agricultural pducts, is seeking a Ph.D. scientst to joina growing research team dedicated to the development of novel vaccines for diseases ofveterinary interest. As part of our continued commitment to research in this area, we arelooking for applicants who have specific expertise in the research technologies needed todefine viral proteins which confer serologically and cellularly mediated protection. Theymust be able to conceptually and strategicafly advance our knowledge in the area ofepitope immunology and immunopoendation, as it applies to the development of novelvaccines, both through indMdual prqects, and through interaction with other scientists. Tobe considered, you should be a creative scientist and have relevant post doctoral exper-tise in monoclonal antibody and T cell doning techniques and in assays used to define Tcell populations.Kalamazoo is a medium-sized Southwestern MAchigan community with immediate accessto a mix of excellent cultural, educational and recreational pursuits, including numerouslakes and a four-season dimate. Upjohn offers a very competitive salary, commensuratewith experience and an outstanding benefits program.

For confidential consideration, please call toll free 1/800/253-8600, ext 3-6767, (insideMichigan call collect 616/323-8767) to request an employment application be sent to you.Please refer to Ad Number 21960-F when calling.

An Equal Employment Opportunity Employer MIFOur commitment to scientific excellence continues...

I _ A

RESEARCHASSISTANT

DNA Sequencing GroupA challenging position is open in theDNA Sequencing Group at CetusCorporation located in Emeryville,California. The successful candidatewill join a team highly skilled in DNAsequence analysis and the latestmolecular biology techniques. We en-courage innovation and provide oppor-tunities to become involved in a widevariety of research projects.Applicants must have a B.S. in a rele-vant field, and have experience in amolecular biology laboratory. Prefer-ence will be given to applicants withprior DNA sequencing experience.Strong organizational skills as well asthe capability to function independ-ently are required.Cetus Corporation is a leader inbiotechnology-based therapeutics forcancer and infectious disease. Weoffer competitive salaries and excel-lent benefits. For confidential consid-eration, please send your resume to:Cetus Corporation, Box MBS, 1400Fifty-Third Street, Emeryville, CA94608. We are an equal opportunity/affirmative action employer.

EELUSCE u5

. SASSSPECTROMIETRY!ENGINEER

An individual is required to assumeresponsibility for a maintenanceprogram involving seven GC/MSsystems including three Nermagquadrupole instruments, two VG70-series magnetic sector instru-ments and two older instruments.The successful applicant will havethe ability to diagnose, repair andmodify electronics at the compo-nent level, will have or develop acomprehension of thefunctioninqmaintenance and repair ofGC/M%instruments, and possess goodcommunicative skills. Two researchassistants are available to assist inroutine maintenance. The engineerwill have the option toparticipate inareas of instrumental development.In Spring 1989, the Mass Spectrom-etry Center will move into a newlyconstructed facility. The positioncarries an attractive salary andfringe benefits commensurate withapplicant qualifications. Send acurriculum vitae byMay 10 1988to:Dr. Ian A. Blair, Director, MassSpectrometry Center, Pharmacol-ogy Department, School of Medi-cine, Vanderbilt Univerity, Nash-ville, TN 37232. AAJEOE.

An Uncompromising Commitment to

Scientific ExcellenceThe atmosphere at Genentech is uniquely tailored to maintain a stan-dard of excellence, encourage creativity and provide personal andprofessional growth for the members of our multidisciplinary teams.

We encourage our people to conduct basic research, publish in theleading scientific journals, attend and present their work at scientificconferences, and to maintain close ties with the academic com-

munity.

We currently have a number of openings for individuals with Ph.D.'s,Master's and Bachelor's degrees within the following fields.

Basic ResearchCardiovascularCell GeneticsImmunologyEndocrinologyNeurobiology

Pharmacological SciencesCardiovascular

Drug MetabolismImmunologyEndocrinology

Process SciencesProtein Purification & Characterization

FormulationsCell Culture R&DFermentation R&D

Medicinal & Biomolecular Chemisuy

Genentech offers an excellent salary and benefits package coupledwith the opportunity to make a significant contribution to our organ-

ization.

We'll be attending the FASEB meeting in Las Vegas. See our postingsin the placement service area or send your resume to HumanResources Department S-22, Genentech, Inc., 460 Point San BrunoBlvd., South San Francisco, CA 94080. Please mark to the attentionof Victor Smallberg for Basic Research and Med&Bio Chem positions,Eric Mankuta for Pharm Sci positions, or Joyce Goulden for ProcessSci positions. An equal opportunity employer.

Genentech, Inc.3sanTho 0noo

k

l

(r

POSITIONS OPEN

INSTRUCTOR. A nontenurd esearch position isavailablc to teach graduate students mollar biologytechniques. Duties to incude team research on molecularbasis of gene expression through use of somatic ccllgenetics and yeast molecular biology. Require a Ph.D. inbiochemistry and at least 2 years of pstdoctoral researchexcperience in molecular biology. Research expencncemust incude techniques ofD A doning and sequenc-ing, site d mutagenesis, footprint4 amplifica-non of gnomic DNA by using PCR; isolation of drug-resistant mutants and yeast tran m S. Submit cur-riculum vitae, currnt publication list, and threc referenceles to: Persnl D r en Re uis no.Y240, TheUnir,o£3c Soutwetn MedialCenter at Dallas, 5323 Harry Hines Boulvard, Dal-as, TX 75235.An Equal OppiMrn4yffinua6wAaiox

Employer.

ISOTOPE GEOLOGISTSThe Instutc of Geology at the Ruhr University

Bochum (Germany) is establshing a research program inotope ology and has one opening in stabl isotpes

and anomer one in radiogenic t The positons arefor an "Akademischer Rat (A12/A13; lifme positionafter probation) and a "Wi sensch Mitarbeite(BAT Ill/BAT IH A; 4-year po ctoral poition). Thetwo appointments will be complementary, and the klvlsbased on the experience of applicants. Ph.D. equivalent,pior experence In praration techniques and massspectrometry, and working know ge of German areessential. Bacgound in sedimentary systems is an ad-vantage, but not precondition.

Deadline for applications, with two confidental letersof reference, is 4 May 1988. All cospone to:Institut fiir D-Ru -Unitiochum,4630 Bochum 1,

MOLECULAR BIOLOGIST. A researdc positionin molecular biology is currently availabk in our Depart-ment ofPhysiology and Medicinc. The person appointedwill collaborate with the group actively vworihng innonhuman primatc lipoprotein biochemit and metab-olism. (This datmls baboon resource ex 2000in number). The position requires a Ph.D. in biochemis-try/molecular biology withthree or more years ofcxper-ence. Salary and rankwill depend upon qu ons andexperience. Please send your currculm vitae and rc-searc intrsts wi the names and telephone numbersof thrc rferences to: Personnel DIcor (838),Southwest Fondation for Biomedial R ch,P.O. Box 28147, San Antonio, TX 78284. EqulOpportunity EmployerMIF.

MOICULAR BIOLOGISTThe Wiship Cancer Center of Emory University

School of Medicine in Atlanta, Georgia, is recuiting amolecular biologist to work in the cancer-rdated ficks ofdevelopmental bioy, gene stucture and regulation,oncogeic viruses and/or cellular growth factors. Experi-ence withe use of transgenuc technology would beespecially desirable. A successfl candidae will be re-cruited at the level of assoate r or professor,depending upon experience. Ihe icumbent will occupylaboratory space in the new Wimship Cancer Centerbuilding. This space is adjacent to multipl shared Uni-versity fcilities, inudinw the mic c facility formokcular biolgy, the fermentation laboratory, the cellsorter laboratory, the monodonal antibody laboratory,the barier mouse facility, etc. A successfil candidate willhave the oppornmity to interact withc andstudents dw h the Cancer Ccnter, t the De-partment of Biochemistry and its reated prgrams inmolecular biology, through the intrerntal pro-

m genetics, and through the gracuate division of5gical Sciences. Emory University Medical Schoolhas abrad clinical base encompassing five metmpolitanhospitals and the reginal cancer registry. It is located onthe suburban Emory Univesity campus, which it shareswith the other gaduate and professional scwols, theundergraduate college, U.S. Centers for Disease Control,the Yerkes Primate Center, and the National Headquar-ters of the American Cancer Society. Intersted candi-dates should send their curriculum vitae and the names ofthree rcferences to: Dr. Kenneth W. Sell, DirectorWmship Cancer Center, Emory Univerity School ofMedicine, Atanta, GA 30322, by 1 June 1988. EmoryUniemiy is an AffirmativeActiom Ex*lyer.562

POSITIONS OPEN

LIPOSOME EXPERTSenior position, basic and developmental search

opportunity fior growt and participation. Submit r&su-mi, pubications, salary history, and reference to:

Technog Unui IncTX DivsionP.O. Box 723

Wooster, OH 44691

The Smithsonian Tropical Research Institute is hiringa MANGROVE ECO)LOGIST to inestigate man-grove forests after a large oil spill on the Caribbean coastof Panama. The position is tempoa y, with continua-tions possibk until March 1992. Salay sars at $27,172per year plus bl addtonal overseas allowances.Applica ns, inchdig curricum vitae and names ofthree rdiaKeF shld be sent by 31 May 1988 to: Dr.B. D. Kelkr, Sm earch Insi-tute, APO Miami, FL34002F1L.

MOLECULAR VIROLOGY/CELL BIOLOGYDEPARTMENT OF MICROBIOLOGY

UNIVERS1T OF VIRGINIAApplications are inited for a tenure-track stion inoleuar virology at the ASSISTANT Or ASSO-

CIATEN PROFESSOR level. Position will include jointappoitment in the Cancer Center. Candidates will beexpected to maintain an active, independent rsearchprogram, and to engage in limited taching of graduateand medical students.7lle dpament ofes a stimulat-ing cnyironnwnt, including well-equipped facilities, andwell-funded graduate anA postdoctral ainiin& pro-grams. Appliants should submit curriculum vitae, astatement of current research activities and future pans,and the names of thrde people fiom whon letters ofrecommendation can be requested to: Dr. Robert R.WvChawnas, Deanentof Microbsok

Unny of V *a of M ,Bcs 41,a ,lflVA22908.An Equal OppmftnityLffiweativeAcaion Emplyfr

NBUROSCIENCE POSTDOCTORAL RE-SEARCH POSITION: Musde sodium channel-mo-lecular biological studies involving the characteriationof skeletl musde sodium channel subtypes. Inchludscloning ofsubypes frnm developing, adult and denervat-ed muscle, analysis ofencoded proteins by oocyte miro-injecion and duough probes of messape ecpression indeveloping and mature muscl. Mechamisms oftemporaland tissue-spcific regulation of expression will also besntuied. NIH pay scales. Send acrriulum vitae andrefeiences to: Dr. Robert Barchi, Direcbor, Institute ofNeurogical Sciees, Universy of PennlaniaSchool ofMedicine, Phiadehia, PA 19104-6074.

PHYSIOLOGYThe Department of Biological Sciences of lUniversitc

du Quebec a Mon&ial is seekdng for a TENURE-TRACK POSMON in physiology. Candidates musthave a Ph.D. in this field as well as postdoctoral experi-ence. Proven ability in research in the physiologicalaspects of occupational health and safety is required aswell as tcadcing cxpericnce in physiology. teachingresponsibilities (m French) willbe in thefidsofanimalphysiolgy,comparative,ex_ taland human Physi-

oloy. he ostio isto c illd b 1August 1988.dcurriulum vitae (in French), and three letters of

referencc, before 25 May 1988 to: Dr. Jean Ging,d ur, Dp t des sbiogiques Un-iversit6 du QuEbec d Montral, C.P. 8888, ccale"A", MontrEal, Qubec, H3C 3P8, Canada.

POSTDOCTORAL FELLOW position available 1August 1988 to study the dtree-dimensional sture ofcnzymes by x-ray crysulBogphy and site-directed muta-genesis. Possible prots include the strucue and mech-anism ofmuconate lactonizing enzxyme fromP.putida, orthe structure of rocA. Candidates shuld be rcent PhDswith experience cither in molecular biology or x-raydiffraction. Send curriculum vitae and three ktters ofrecomendation to: Dr. A. Goldman, Waksman nsti-tute, Ru s University, P.O. Box 759,P ,NJ 08855. Ru.qm is an Equal Op nityLJ aAtion Employer.

POSITIONS OPEN

PLANT CELL CULTUREPROFESSORSHIP

TheDept of Botany and Plant Pathology atMichigan StateUniversity, together with the MichiganBiotnogy Institutc, announces a joint, tenured fac-ulty position for an accomplished investigator with ex-pertise in plant cell culture to be filled at the full orassociate professor leve. Candidates should have demon-strated ability and research intcrest in the applications ofplant cell cuure. MicJ4*an State Univeuy and theMfickisan BiotecJmy Institcu are Afflnative AtionEqual OpportunityEmplye,r. Please send curriculum vitaeand names and addrees of three refercnces by 7 May1988 to: Dr. Christn T. Stephens, Search and Selec-tion Commitee C Departent of Botanyand Plant Pathoy, State Univerty, EastLansing, MI 4L88241312. We wekome nominationsas wel as applications.

POSTDCTORAL-BIOCHEMISTRY-2-year ap-pointment to study the molecular aspects of protein-protein interactions of tissue culture systems. Salary:$18,000 to $20,000 with housing possible, famil medi-cal and dental provided. Modem envatly funded labora-tory. Dirctor, Biomedcal DivWion, Noble Founda-tion, P.O. Box 2180, Ardmore, OK 73402.

POSTDOCTORAL FELLOWAND TECHNICIAN

Sought for AIDS-rebted reserch with experience andinterest in ither:

1) Molecular biology, particularly RNA/DNA hy-bridiation (in situ, Nordtern, Southen), and subdon-ing, or

2) Ncurobiology of maunm brain, particularlyprimary culture of neural cells, and histochemistry.

Positions include opportunities for advancedcoursework, publication credit, and job advancenmnt inthe Public Health Service, National Institutes of Health,National Institute of Allergy and Infectious Discases,Laboratory ofImmu tion, Bethesda, Maryland.Biok* microbiologist; biodxhmist-GS-09

$22,907 per annum. Po ral flow $24,000 to$38,588 per annum. For position information contact:Dr. L Vithwvc: 301 6 . NHNIAID, 9000Rockvile Pike, Building 10, Room 11B13, Bethsda,MD 20892. For qualification information contact: Ms.Jane Schriver: 301 496-4634. U.S. citei required.NIH is an Equal Opporunsty Emplyoer.

POSTDOCTORAL FELLOWREGULATORY LIPID BIOCHEMISTRYA position is availabk in a wel-funded laboratory to

participate in an ongoing research program focused onthe biochemical characterization and coning of kcyenzymes that modulate prokaryotic lipid metabolism.Candidates with a Ph.D. degree interested in applyingcontemporary techuiques of mokcular genetics, proteinpurification, and antbody production in this area shouldsubmit their curricuum vitae, reprints, and names ofthree refcrences to: Dr. Charles 0. Rlck, B Io4 mIDepartment, St. Jude Childrn's Research H332 North Luddak, Memphis, TN 38101. AnEqual OpportnisylAffimatieAcimn Emplyer.

POSTDOCrORAL FELLOWRESEARCH AS-SOCIATE (with potential for advancment) in molecu-lar biology, expeence with cell culture and peptidesdesirable. To wok in a productive, funded laboratory atHarvard Medical Scol, invegating gastrointenalpeptides. Salary commensurate with qualifications andexperience. Send curriculum vitae and the names ofthreernces to: Dr. MichaelWolfe, Beth IalH l,330 Brookline Avenue, Boston, MA 02215.AnAr-matieActionEqual Oppor0uity Employer.

POSTDOCTORALFELLOWSHIP is availabk fora lipid biochemist inteested in investigating the bioregu-lation, biosy and degradation of the platekt acti-vation factor and its interaction with other liid media-tors of inflam n. A strong an ai b nd isdesired. Pkase send your rEsumE to:M n Quigle,Professional Employment RqmnDstive,nmericanCyanamid Compn, Medicaliesac DivionL-die Laboratores, Pearl River, NY 10965. EqualOpprtunity EmpklyerAMF.

SCIENCE, VOL. 240

MolecularGeneticsResearch

New potions are opening now through 1989in the Molecular Genetics Research Depart-ment of Pfizer Research in Groton, Connec-ticut. These postions require a PhD plus twoor more years of postdoctoral researchexperience in one or more of the follwingareas:

* Tissue ecfctanscription control. Heterologus gene expression inmammalian cells

. DNAbinding proteins isolation/cloning* Enhancer element acterizon

. Trans-acing factor identifiction

. Development of transgenic animalsYou will be expected to establish an indepen-dent reseah labratory as part of a multdis-ciplinary group effort. Our group is toexplore mehanisms which tissuespeific expression of sted genes in man

in order to discover novel drugs which modu-late those pocsses. Selcted targ includearthritis,ais and modulation ofimmune responses.

We offer an excellent opportunity for profes-sional recognition and growth, a stimultngscientific environment, challenging researchpr s, a competftive compensaton andbenefits plan and location in an ativecoastal community in southeastern Con-necticut.Qualified candidates may submit resume,nares of three references and a summary ofresearch experienc to: Jerry K. Larson, PhD,Manager of Employment, Pfizer CentralResearch, Eastern Point Road, Groton,CT 06340.

An equal opportunity empkWer

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BiologistDrugEvaluatorHealth and Welfare CanadaBureau of Human PipionDrugsOttawa, Ontario

a sciendst to evaluate

experimental data in drug submissionsfrom pharmaceutical companies todetermine the pharmacological,toxicological, pharmacoldnetic andclinical effects of central nervous systemdrugs. You will be required tosummarize, assess and critically evaluatesciendfic data pertinent to the safety andefficacy of drugs, and to formulatejudgments and reach practical decisionsregarding the same.

You graduadon with a doctoral

degree in pharmacology, toicology or arelated field from a recognizeduniversity, or a lesser degree withevidence of research experienceequivalent to that of a doctoral degree,and some pracdcal experience.Knowledge of research design for theprecilnical and clinical research of centralnervous system drugs and blostadstics areessential. Knowledge of English Isessendal.We offr a salary ranging from $48,139to $55,591 commensurate with yourqualifficadons and experience.

Please forwurC your r sumiandfor appl in form, quodngreference number5-88-31-6247-47JG-G35, to:Joan Girling (613) 996-8054Public Service Commission ofCanadaOttawa, OntarioK1A OM7

losing dates May 12, 1988Personal informadon you provide Isprotected under the Privacy Act. It willbe held in Personal Informnadon BankPSC/P-PU-040, Personnel Selection Files.

T Publc Serviae ofCaaaeb an eqanlrlcnty

PERSONNEL PLACEMENT 563

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Pubk Swvlm Co Osseo o moolo de b Foiiedoi1+I of conam -'- du

of the Neurosciences Research ProgramThe Do chZi cOf Comany risanBWoPunit Empl%w _^vv^_ v ^

NEW ENGLAND BIOLABS POSTDOCTORAL SCIENTISTNew England Biolabs, a pioneer and leader in biotech- EXPLORATORY RESEARCHnology located twenty mfles north of Boston is seekingapplicants. Amgen is a dynamic and growing organization that is a

Postdocto -al Positions recognized leader in recombinant DNA technology. Our

Postdoctoral Positions leadership in developing erythropoietin and other products

Gene Cloning-Candidate should have training in bio- for human therapeutics, human diagnostics, animal healthchemistry/enzymnology and molecular biology. Projects care and specialty chemicals has placed us firmly in theinvolve the cloning, overproduction and mutagenesis forefront of the industry. We currently have an opportunityof restriction modification systems. for a Postdoctoral Scientist to contribute to our ExploratoryMolecular Genetics-Candidate should have strong Research Group.background in molecular biology or bacterial genetics Qualified candidates will have a Ph.D. in the avianto study the interaction between restriction modifica- molecular biology of growth physiology or disease resis-tion systems and the host cell. Knowledge of protein tance or a Ph.D. in the mammalian molecular biology ofchemistry would be helpful. lipid metabolism, hematology, endocrinology or im-

In addition to competitive salary, New England Biolabs munomodulators.offers a very generous fringe benefits package. Atten- Amgen offers a stimulating and challenging research en-

dance at meetings, publication of research results and vironment as well as an attractive location (about an hour

open communication with others are encouraged. northwest of Los Angeles). Amgen also offers a compe-

Candidates please submit curriculum vitae with three titive compensation and benefits package. Qualified appli-references to: cants should send a resume, in confidence, to:

New England Biolabs, Inc. Recruitment, Dept. #113Human Resources AMGEN

32 Tozer Road 1900 Oak Terrace Lane

Beverly, MA 01915-5510 Thousand Oaks

CA 91320

NEW ENGLAND

,#_ v_Dfs w Equ Oppotunty Epobyer

RESEARCH OPPORTUNITIES

AGRONOMIC RESEARCHThe Dow Chemical Company, in Midland, Michigan, is arecognized global leader in the agricultural chemicalindustry. Expanded research efforts in the area of plantgenetic engineering have created an immediate needwithin the Biotechnology Laboratory In the CentralResearch Department for a:

PR ICHEIST

The successful candidate will have a Ph.D. in ProteinChemistry with experience in state-of-the-art techniquesfor protein isolation, purification and characterization.Research efforts will be directed toward the identificationand characterization of agronomically important proteins.

The above candidate must also possess strong com-munications skills and a desire to carry out independentresearch while functioning as part of an interdisciplinaryresearch team.

The Dow Chemical Company offers a stimulating workenvironment and a competitive salary and benefitspackage.

uaMed applkant should send resume to:

P.O. Bo 1655Mdland, 466 -1655

FELLOWSHIPS INTHEORETICAL NEUROBIOLOGY

The Neurosciences Institute invites applications for positionsas Institute Fellows in Theoretical Neurobiology. InstituteFellows receive a stipend and are usually appointed for aperiod of two years with discretionary renewal for up to anadditional two years.The Institute is an independent organization located on thecampus of The Rockefeller University in New York City.In addition to serving as the home of the NeurosciencesResearch Program, the Institute is a center of study andresearch for distinguished visiting neuroscientists. The Insti-tute also supports a program of research in theoretical neuro-biology which seeks to develop detailed simulations ofneural function that are biologically based and experimen-tally testable. Current projects include the construction ofcategorization automata, analysis of synaptic modificationmechanisms, and detailed simulations of various cortical andsubcortical regions.Applicants should be at the postdoctoral or assistant pro-fessor level. A background in experimental or theoreticalneuroscience or related fields is required; training in physicsor mathematics will be viewed with favor. Applicants shouldalso have some computer expertise.Address applications to Dr. W. Einar Gall, Research Director,The Neurosciences Institute, 1230 York Avenue, New YorkNY 10021. Include a short statement of interests, a curric-ulum vitae, and the names of three references.

~~~The Neumosciences Institute

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DISTINGUISHED RESEARCH FELLOWSHIPSLOS ALAMOS NATIONAL LABORATORY

The Medical Radoisotopes Research Program is seeking out-standing recent Ph.D. recipients for the posdoctoral fblow-ships described below. All positions require responsibility forplanning, initiation, and implementation of independent re-search and prsentaion of research resufts. The ability towork as part of a team is also required. Compensation of$32,820-$34,580 per annum provided; possible renewal for asecond year.

Blochemlst, medicinal chemist, or organic chemist todevelop methods to label antibodies, using linkers to achievehigh levels of attachment of chelating agents to antibodies.Synthesize linker-chelate conjugates to be covaently attachedto antibodies at a site remote from the antgen-binding sites.Determine stability, affinity, and immunoreactity of labeledantibodies. Experience in protein modification or immunologi-cal methods is desirable.Synthedtc nognic coordinaton chemist or syntheicorganic chemist to design and synthesize chelating agentsfor metal radionudides and paramagnetic metals. The che-

lating agents must (1) fbrm extremely stable complexes withthe metal ions and (2) have suitable funrconal groups forcovalent attiahment to linker molecles and antibodies.Determine the stability of the chelates under simulatedphysiological conditons. Experience in synthesis, radio-labeling, or chelating reac is ruired. U.S. ctzenhIpIs required.

Analytcl, ecoaaly al, Inorganic, or radlochemist todevelop chemical or elecbochemical separation procedures on

a no-carrier-added level to isolate radioisotopes of interest tothe nudear medidne research community. Perform chemistryin radochemical hot-cells. Develop new radioisotope genera-tor systems. Interact with radiolabeling and biodistributionsearhers in the Program. Experience in analytical separa-

tions (ion-exchange, solvent extraction, electrodeposition) andgamuma-ray analysis is desirable. U.S. citizenship Is required.Intersted candiates should send a resume to Dr. JanetMercer-Smith (biochemistry, medicinal or organic chemistry;syntheiec inorganic coordination or organic chemistry) or to Dr.Dennis Phillips (separations chemistry) at INC-11, MS J514,Los Aamos National Laboratory, Los Alamos, New Mexico87545 or phone (505) 667-2646 (Mercer-Smith) or (505) 667-4253 (Phillips).

To fbrmally apply, send a resume, bibliography, three letters ofreference, and graduate and undergraduate transcripts toCarol M. Fich (MS P290), Human Resources DevelopmentDivision PD-88-017, Los Alamos National Laboratory, LosAlanos, New Mexico 87545.Affirmative Action/Equal Opportunity Employer

University of Califomia

O$ L0\DSBTh©THE ABBOTT SCIENTIST IS AT THE HEARTOF NEW ADVANCES IN DRUG RESEARCHWhen it comes to new drug development in the treatment of vascular disease, the Abbott name comes up againand again. As a $4.4 billion health care leader worldwide, we have the talent, strength and exceptionalmanagement to make us a successful innovator. We now seek the following Research Scientists to support ouron-going advances within our Pharmaceutical Products Division.

PH.D. CARDIOVASCULAR PH.D. BIOCHEMISTPHYSIOLOGIST/ As a member of our Renin Inhibitor Project Team,PHYSIOLOGIST! T individual will set up and modify procedures inPHARMACOLOGIST screening compounds for inhibitory activity againstResponsibilites will entail discovery and developmental renin and other enzymes, determining drug plasmapharmacology of drugs for the indication of congestive levels, studying stability of compounds, and in enzy

heart failure, and will involve setting up models of purification and kinetics. A Ph.D. in Biochemistrycongestive heart failure in small and large animals. plus at least 6 years postdoctoral experience in HPIPh.D. in cardiovascular physiology/pharmacology and the areas mentioned above are essential.required. Post-doctoral experience and a strong Experience in automated sample analyses and datebackground in cardiac function supported by base management preferred.well-developed written and oral communication skillsare essential.Consistently recognized as a top American corporation, Abbott is able to provide a superior scientificenvironment at our headquarters just 30 miles north of Chicago on the Lake Michigan shoreline. We alsooffer excellent salaries and benefit packages that include prom sharing and stock retirement plan. Forconfidential consideration, please send your resume with salary history to: Patricia Handy/CorpoatePlacement, Dept. SCI/4/22, Abbott Laboratories, Abbott Park, IL 60064. Abbott is an affirmative actionemployer.

ABBOTT LABORATORIES MEETING BOUND?Abbott Representatives will be at the

Quality FASEB meeting in Las Vegas, May 2-6

V oealth CAre To arrange an interview,100 g MWrldwide or if you will not be able to attend,

send your resume to Patricia Handy.

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18118-1988

POSITIONS OPEN

POSIDOCTORAL POSMON to study peptidehormonc receptors on a molecular level, including genecloning, exression, structure-function relationships. Ex-cellent environment availabk in multdisciplinary inter-departmental program incorporatng de chmisiyand ckctrophysiology into biochemical cellular, andmolecular investigations of the digestive tract. Sendcurriculum vitae, names of three references to: Dr. L J.Miller, Gastrocntero1Ogv Rcarch Unit, Mao Medi-cd Sdwol Rohstr,MN 55905.AnEq OppC -

nitylAffirmativeAa-in Imtiution.

POSTDOCTORAL POSMONBROWN UNIVERSITY

Position availablc for individual intrsted in areas ofprotein structure-function, gcne strc and regula-tion, protein-nuckic acid intractons, or mokcularmehanisms of recombination. Previous expenec with(or desirc to karn) protein chemistiy, nucleic acd bio-chemistry, DNA cloning, genetics or in vitro systems.Pleasc send r=sume with desired sarn date and list ofthree refrences to: Arthur Landy, Divion of Bioloand Medicine, Brown University, Providence, Ru02912.An Equa OpportuyL4frnnatmAasm En*kw.

Applications are being accepted for a POSTDOC-TORAL POSIION with opportunities for research inall phases (basic and clinical) ofa radioimmunoconjugatecancer treatment progam. Some xperienc in immunol-ogy, monoclonal anibodies, immunoassays, radioiso-tope labeling, or radioimmunoscintography in animalmodels or in clinical trials would be he[pful. Potentialexists for independent investigation and fcture tenure-track position. Send curriculum vitae, briefdescriptionofprior research, and three references to:

Marpa A. Tempero, M.D.Associate Professor of Medicine

University Mecal Center42nd and Dewey AvenuOmaha, NE 68105-1065

POSTDOCTORAL POSMON availabk immedi-ately for biochemist with experience in protein chemistryto participate in study of structure/function rclationshipsin prostaglandin biosynthetic enxymes. Please send cur-riculum vitae and the names of three re nces to: Dr.Richard Kulncz, Department ofBiohemit, M/C536, University of Il s at Chicago Chicago, IL60612.

POSTOCTORAL POSITION available immedi-ately for molecular biologist to investgate properties ofaretrovirus produced by human embryonal carcinoma(EC) cells and mechanisms regulating virus replicationand EC cell differentiation under directon ofDr. DavidBronson. Annual salary ranges from $20,500 to$23,920, dependent upon experence. Please mail curric-ulum vitae with names and tclephone numbers of threerefrences to: Personnl Director (837), SouthwestFoundation for B edical Rach, P.O. Box28147, San Antonio, TX 78284. Equal OpportunityEmployefMAF.

POSTDOCORAL POSMONSECTION ON VIRUSES AND

CELLULAR BIOLOGYNATIONAL INSTITUTE OF CHILD

HEALTH AND HUMAN DEVELOPMENTNATIONAL INSTIUTES OF HEALTH

Applications are invited for a postdoctoral (Ph.D. orM.D.) position, availabl immediately, for in vivo and invitro studies on molecular mcchanisms ofDNA replica-tion, repair, and mutagenesis in nummalian ceUls.A background in molecular biology or biocmit is

required, and prefercnce will be given to candidates withcxperience in nucleic acid and enzyme chemistnr. Salarywill be co mnsurat with experience and qualicaions.

Please send curriculum vitae, the names of threreferences, and a brief summary of research accomplish-menits and goals to:

Dr. Katheen DixonSection on Viruses and Celular Biology

NIH NICHDBuilding 6, Room lA159000 Rockvilk PikeBethesda, MD 20892

An Equal Opportunity Employer

566

POSITIONS OPEN

POSTM OCIO RAL POSMON availabk immedi-ately to carry on genctic a of and tostudyregulation of gene for histidine dcaoylase from Lac-

dl. Background in microbial genetics is desirable.Scnd curriculm vitae, short r mu oflaboratoryeperi-ence, and names of three references to: J RobertusDeatment,of Chemiitry, Univerity of Tcxas, Aus-tin, TX 78712. Telphone: 512471-3175.

POSTDOCORAL POSMON availabk to studythe export of E. cdi envelope proteins. Interactionsbetween exported protens and the proteins of the cellu-lar secetory machinery will be analyed using moleculargenetic and biochemical approaches. Expience in bacte-rial genetics or molecular biology desirabk. Send curric-ulum vitae and the names of three references to: Dr.Carol Kumamoto, De of Phi p andMdrsubrB _l, Tus Uv

School of Medicne, 136 Harson Av , Boston,MA 02111.

POSTDOCTORAL POSMON available 1 June1988 to study the mechanisms and genetics ofresistanceto pyrethroid, organophosphate, and carbamatc insecti-cides in the German cockroach. Expeience with toxico-logical techniques desirabk. Position is a 1-year renew-ablc appointment. Send curriculum vitae, three ktters ofreferece, and a copy of ranscrpts to: Dr. Je G.Sott, Dewrtment of Entomo ogy, Comatoek Hall,Corndl niversity, Itha, NY 14853.

POSTDOCTORAL POSMON for rocent Ph.D.(pharmacology or biochemistry) with exprience in mo-kcular biology, to study endothelial surface antigens inthe intact lung. Project will address cellular and molecu-lar mechanisms of endothelial activation both in theintact lung and microvascular cells in culture. Resumniand three ktters of reference to: C. Normnu Gillis,Ph.D., Departnt of s esiology, Yale Universi-ty ofMedidne, 333 Cedar Steet, New Haven,CT 06510. rak Uni y is an Equal EploywentAfiomativeAcaion Employer.

POSIDOCTORAL POSMON availabk immedi-atchyto study the interaction ofnew antneoplastic agentsand new therapeutic modaities with DNA m tumor andnormal tissues. This work involves applying molecularbiological techniques to defined sequencc DNA andDNA isolated from munne modl systems. Joint ap-pointment will bc hld mnan appropriate deparmet oflIarvard Medical SchooL Send curriculum vitae andnames, addresses, and telphone numbers of three references to: Dr. B. A. Techer, Dana-Farber CancerIstitute, 44 Bimnne Strect, Boson, MA 02115. AnEqu OpporeunityAfiswAction Empkyer.

POSTDOCTORAL POSMONS availablc in aninterdisciplinary program on human immunodeficiencyvirus sequences in immune responsc and pathogenesis athe Umversity of Massachusets Medical Center andHarvard Medical School, Ncw England Rcional Pri-matc Center. Partating laboratories inc4 Drs.Elarrit Robinon, Raymond Wdsh, Chdstie A. Hol-land,Trudy Morrison, CarelMulder,Norman Letvin.Interested candidates should send currkulum vitae andnames of three references to: Program Director Dr.Harriet Robinson, Dep t of Patho , Uni-verity of Massachu Medcal S l, 5 LaAvenue North, Worcester, MA 01655. An EqulOpportunxey/AffinawiveAtin Employer.

POSTDOCTORAL POSMIIONSNIH-funded positions available in the Brain Research

Institute at the University of California, Los Angeles(UCLA) Medical Center to investigate biochemicalmechanisms of blood-tumor barrier permeability or re-ceptor ligands to specifically imapy brain tumors in vivo.Research involves computer-aided 3-D quanitativeautoradiographs ofreceptor binding to brain tumors andblood-brain barrier permeability. The salary is $25,000to $30,000 per year, depending on experience. Submitcurriculum vitae and names tMe to: Keith

L, Blak, M.D., Division of Neurosrgery, UCLAMedical Center, Los Ang , CA 90024. Tcelhone:213-20-&3356. UCLA s an Equa Op uity andAffirmativeAcaion Emplyer.

POSITIONS OPEN

POSTDOCTORAL POSiIION. Avaabe imme-diately for a scientist with expericnce with DNA probesand/or immunochmistry and immuunocytchemistry;cell culture. A background in molecular biology is desir-able. Research involves a study of the regulation of thesynthesis and proccssing of proteins of the neuronalcytoskkton in development and in the pathogis ofneurodegenerative disease. Contact: Dr. Davi SoiferLabatory of Cell Bioy, NYS Institute for BasicResearch in Developmental Disabltes, 1050 ForestHill Road, Staten , NY 10314.

POSTDOCTORAL POSMON. Available imme-diately. Biohemaist/biophysicist intested in thestudy ofribosome function usi a co.mbinn of chemicalmodification and quantitative high-rolution ectonmicroscopy. The applicant should be a recent Ph.D. witha strong ba round in rron chemistry and clvonmicroscopy of macrmolecules. Sendcurriculum vitae,summary of reseah experien, and names throerrnces to: Dr. Joachi Frank, Wadsworth Centerfor Laboratories and rch, P.O. Bar 509, Alba-ny, NY 12201-0509.An Equal OpponvnisyAJffiwatinAction Emplyf.

POSIDOCTORAL POSmONS IN ENDO-THIAL CELL BIOLOGY. Research programs fo-cus on rok of venular endodtlium in angiogenesis andtransmicrovascular exchanpe processes. Emphasis on cellculture, surface receptors, signaling and cdl/cell interactions. Experiencc in cel biology, biochemis-try, or immunokogy desirable. Send curriculum vitae,names of three references, and statement of researchinterest to: Harris J. Granger, Ph.D., Professor andHead, Departmcnt ofMedical Physiolg, College ofMedicine, Txcas A&M Univrsity, Coge Sation,TX 77843.

POSTDOCrORAL POSMONS-PIANT MOLECULAR BIOLOGYUNIVERSITY OF FLORIDA

Postdoctoral positions are available immedie in thefollowing areas: (i) Targeting and assbly of chloro-plast membrane protins. (ii) Molcular c trizationof the shrunken-2 locus- of maize. (iii) S e andfunction ofthe vim,ass-1 ocus ofmaizc. (iv) Molecularanalysis of the citrus tristeza virus (CTV) genome.Candidates are being sought with a Ph.D. in biochemis-try, molecular biology, geneics, or related discipline.Experience with recombinant DNA tochniqucs as well asplant systems is desirabl Salary ($20,000 to $23,000)will depend upon background and prior experience.Pleasce send rdsumb and three letters of reference to:Kenneth Cline (chloroplasts and CI'V),L Curtis Han-nah (sbruken-2), Don:ad McCarty (vaiv -1) doInterdisciplry Center forB clogy Reearch,1301 Fiield Hall, Universiy of Florida, Gaievile,FL 32611.

POSTDOCORAL POSMONSTRANSGENIC MODELING OF

HUMAN DISEASEMOLECULAAR BIOLOGIST sought to study

expression of the hepatitis B virus genomicm transgenicmice. Opportunity to produce and analyrze ngeicmice that express HBV-encoded polypeptides; to exam-ine questions related to virl partidc assemby, transportand secretion; to explore viral receptor biology; andinvestgate the molecular basis of HBV induced tohpatocellular injury and malignant transformation.CELLULAR IMMUNOLOGIT sought to sntdy theimmune response to hepatitis B vius encoded antunsin transgemic mice. Opportunity to investigate immuno-logically mediated tissue injury, mechani of autoim-munity and immunological tolrance. Available immedi-ately. Applca must be U.S. ceWnm ordent. Send curriculum vitae, statementests, and names of three references to: F. V. Chisari,MD., Departmnt of Basic and Clnical Research,Research Institte of Scripps Clinic, 10666 NorthTormey Pines Rod, La Jol CA 92037.

Equal Oppotunity Emplyer

SCIENCE, VOL. 240

POSITIONS OPEN

POSTDOCORAL POSMONS-INSECT Ll-POPROTEINS. Positions will be availabk after 1 July1988 to study insoct lipoprotein biosynthesis (JBC 261,17174), apoprotein sequence and sture (JBC 262,11794), control of apoprotein gene expression and lipo-protein fiExcpon andncebolism Ee nce in molkcu-larbiologisdesired for one position. Salary comume -

eateience. Send curriculum viae and dienames, addres, and teekphone numbers of dtree refer-ences to: Dr. Mihael A. Wells, Departmet of Bio-chemistry, Biosciene West,Ihe UniveritofAi-ns, Tucson, AZ 85716. AnEql Oppeun m AtvtAeam Employfr.

Applications accepted until position is filled.

POSTDOCTORAL POSMONSMOLECULAR AND CELL BIOLOGY

Tumor Ccll Biology Department has sevcral fundedpostdoctoral positions available for invesigators interest-ed in studing signal transduction by the CSF-1 receptor(c-fins protoncogene) and its oncogene-coded (v-fins)counterpart. Current topics of research inchlde: identifi-cation of"activating" mutations in the c-fins and v-finstransduction into target cells of dient lineages, andbiochemistry of oncogene- and recepor-mediated sinaltransduction. On{oingstudies cmphasize intrdiscplin-ary molecular, cell biogcl, and biocheical approach-es, with a focus on hematoic systems. P~reviousexperience in molecular and cc oy and/or bkochem-istry is preferred, and gencral familinty with oncenes,growth factors, and their receptors would be desirable.Minimumn stipend: $22,000 per annum plus fringe bene-fits. Send curriculum vitac, brief statement of rescarchinterest, and names of threc rceferes to: Dr. Chares J.Sherr, Department of Tumor Cell Bioloy, St JudeChilen's Rech H pitl, Manphis,TN 38104.Equa Oppoeunity/AffitmamiAaim Empkoyer

POSTDOCTORAL/RESEARCH ASSOCIATEPOSMON. Hematopoietic Growth Factors: Apositionis available 1 July 1988 to study the biolc andbiochemical properties ofB cell and hemopoietic growtfactors, and the regulation and eon of grotfactor genes. A backgrund in molecular bogyorbiochmiy is preferred. Pkase send curiculm vitaeand names of three reerecnces to: Dr. Peter Quesen-berry, University of Virgiia, School of Mediine;Box 502, Charlottesville, VA 22908.

POSTDOCTORAL RESEARCHASSOCIATES

Positions for NCI postdoctral training program inmolecular and cellular mechanisms of arnogis arcavailabk at The University of Texas System CancerCentcr (VTSCC-Science Park. Research propams fo-cus on the following areas: somatic cell gentics, DNArepair and mutgenesis, canogen metabolism and ad-duct formation, tumor promoton, mecanisms of lym-peomagncsis, normal and tumor cell differetiation,biochemical geneics, gmrwth factors, and r irss.Applicants must be U.S. citizens or perman residents,and have a Ph.D., M.D., or D.V.M. de. For applica-tion foms contact: Dr. Thma J. Slp, Dictor,UTSCC, Science Park-Research P.O. Box389, SmithvlJe, TX 78957. Telpone: 512-237-2403.An Equ OeA Empyer.

POSTDOCTORAL OR RESEARCH ASSIST-ANT PROFESSOR POSMON. Availabk 1 July1988 to study central neuronal mechanisms which reu-late g ial function using neurophysiologicland nro c t iques. Researchinvolves sagical dissec and stimulaton of penpheralnerves servmg vi sr m and rding trac-lular sing-unit responsc in CNS. Experience in -croiontophoresis and mroprcssur desi Submitcurriculum vite and names of ree rences to: Dr.Wiliam D. Barber, Detment ofAnmy, Colkgcof Micine, Unive of A a, Tuon, AZ85724. osing date for applications 6 May 1988. AnAffimAct Eql OprniE r.

22 APRIL I988

PROTEIN CHEMIST

Merck Sharp & Dohme Research Laboratories is cur-rently offering an excellent career opportunity for aprotein chemist to join the expanding Department ofCellular and Molecular Biology. Research in thisdepartment is applied to the analysis and expres-sion of genes of potential pharmaceutical interest.

Responsibilities for this position will include proteinpurification and characterization techniques suchas HPLC, FPLC, radio-immunoprecipitation, ELISA,gel electrophoresis and immunoblotting.An M.S. or B.S. degree in Biochemistry, MolecularBiology or the equivalent, with at least 2 years ofbroad and significant experience in proteinchemistry is required. Experience in tissue cultureand general molecular biological procedures isdesired.Merck Sharp & Dohme Research Laboratories arelocated in Rahway, New Jersey approximately 25miles from New York City. Our salaries, benefits, andgrowth potential are excellent.Interested candidates should submit resumeand three letters of recommendation to Susan R.Jenkins, Merck & Co., Inc., P.O. Box 2000, Rahway,NJ 07065.

An Equal Opportunity Employer M/F

Sandoz Ltd., a leading Swiss-based internaftonalcompany, specializing in pharmaceuticals, ag-rochemicals and dyestuffs; is offering a

POSTDOCTORAL FELLOWSHIP

for a period of one year at its headquarterresearch laboratories, Biopharmaceuftcal De-partment in Basel, Switzerland.To a person with a recent PhD in biochemistry orbiological sciences, this challenging positionoffers the possiblilty of conducting and publish-ing original research in studies on the in vitrometabolism of xenobiotics. The objectives arethe idenlification, characterisation and evalua-tion of mono-oxygenases Involved in the detoxi-fication of drugs of interest. The position requiresa very good knowledge of Cyt. P-450 enzymolo-gy. Experience in analyfics, immunoassays, ra-dioisotopes and hybridoma methodology is de-sirable.Applications, including curriculum vitae shouldbe sent to: A

SANDOZ LTD.Personnel DepartmentRef. 8802Altn: Mr. R. ZbindenCH-4002 Basel (Switzerland)

S

SANDOZ

RESEARCH SCIENTISTEXPLORATORY RESEARCH

Amgen is a dynamic and growing organization that is arecognized leader in recombinant DNAtechnology. Our leader-ship in developing erythropoietin and other products for humantherapeutics, human diagnostics, animal health care andspecialty chemicals has placed us firmly in the forefront of theindustry. We currently have an opportunity for a ResearchScientist to contribute to our Exploratory Research Group.

Qualified candidates will have a Ph.D. and at least 2-4 years ofpostdoctoral experience in the molecular and cellular biologyof any of the following disciplines: neurobiology, lipid meta-bolism, bone formation, soft tissue regeneration, hematology,endocrinology or immunomodulators. Experience in cDNAcloning and gene expression as it relates to these disciplines ishighly desirable.

Amgen offers a stimulating and challenging research en-

vironment as well as an attractive location (about an hournorthwest of Los Angeles). Amgen also offers a competitivecompensation and benefits package. Qualified applicantsshould send a resume, in confidence, to:

Recruitment, Dept. #1 12BAMGEN

1900 Oak Terrace Lane

Thousand Oaks

CA 91320

Equal Opportunity Employer

BUILDING ANEW LAB?

LET THE SCIENCE FREE PRODUCTINFORMATION SERVICE PUT YOU INTOUCH WITH THE VENDORS WHOSEPRODUCTS YOU WILL NEED.

SIMPLY WRITE US A LETTER STATINGTHE SPECIFICS ABOUT YOUR PROPOSEDLAB AND WE WILL DO THE REST.

WRITE TO:

SCIENCE MAGAZINENEW LAB SERVICE DEPT.1515 BROADWAYNEW YORK, N.Y. 10036

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Research Scientists/AlssociatesSan Franc isco B a y

Triton Biosciences Inc. is a biotechnologycompany focused on diagnostics andpharmaceuticals for cancer and other lifethreatening diseases. This entrepreneurialsubsidiary of Shell Oil Company is seekinggoal-oriented researchers with experiencein the diagnostics industry to help createhigh quality products that fill critical medi-cal needs. Current opportunities include:

Infectious DiseaseRequires a PhD in Microbiology or equivalentexperience. Duties will include the purificationand antigenic analysis of viral proteins, evalu-ation ofmonoclonal antibodies and the construc-tion of sensitive immunoassays. Refer to Box SC.

Molecular ImmunologyRequires a PhD in Immunology or Biochemistrywith further postdoctoral experience in theimmunological and molecular characterizationof protein antigens. Background in tumor mar-kers, cancer immunology and immunoassaydevelopment desirable. Refer to Box RW.

HybridomaRequires a PhD or equivalent with hands-onexperience in all aspects of hybridoma genera-tion and monoclonal antibody production. Activeparticipation in the design of experimentalapproaches for the development of immuno-logical reagents for the diagnosis of canceror infectious disease is required. Knowledgeof antibody purification and conjugation isdesirable. Refer to Box RW/YT.

New Cancer MarkerRequires a PhD in Cancer Biology, Immunologyor equivalent experience with expertise inthe evaluation of cancer markers. Duties includeeffective interaction with a multidisciplinaryteam in evaluating new cancer markers fordiagnostic use. Refer to Box GL.

Histopathology/OncogeneRequires a PhD in Biological Sciences or equi-valent with experience in immunohistochemistryDuties will include the evaluation of antibod-ies to oncogenes, mucins and other new cancermarkers as well as developing immunnohisto-chemical reagents. Refer to Box YT

A r e a

Infectious DiseaseRequires a BS/MS degree in Microbiology orequWvalent experience. Duties will includegrowth and purification of virus, anfibody evalua-tion by immunoblot and enzyme imrnmonoassays,and active participation in the construction ofsensitive immunoassays. Refer to Box SC2.

Moleclar Prote ChemistryRequires a BS/MS degree or equivalent inbiochemistry with experience in the isolation,purification and characterization of proteinsand peptides. Further background in the modifi-cation and conjugation of proteins to haptensand enzymes required. Knowledge of inmuno-assay techniques desirable. Refer to Box RW2.

Histology/Cancer MarkerRequires a BS/MS degree in Biological Sciencesor equvalent experience in immunohistoche-mistry. Knowledge of fixed and frozen sectionpreparation, production of antibodies, and per-formance of immunohistochemical assays isdesired. Refer to Box YT2.

HybridomaRequires a BS/MS or equivalent in BiologicalSciences with experience in cell culture, animalimmunization and monoclonal antibody produc-tion. Knowledge of antibody purification andimmunoassay techniques desirable. Refer toRW/YT2.

Triton offers competitive salaries and ben-efits including relocation assistance. Forconsideration, send C.V. with salary his-tory and references to: Triton BiosciencesInc., 1501 Harbor Bay Parkway, Alameda,CA 94501. An Equal Opportunity Employer.

- Triton0 Biosiences

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POSTDOCORAL RESEARCH FELLOW: TheDq)arm t ofRep v Medkianc at the UniversityOf Califiomlia, San )iego (USCD), has an opening for ap sfi:lbw ressearch physioost)for research in

physiolgy. Studies include physiolgical regulation ofcardiovascular and nkdorin sstem, and of fluid bal-ance in the fetus. Bac siology and animalexperimentation desired. Salary: $24,000 pe year. Sendlettr, curriculum vitae, and three nameso fer to:RobertA. Brace, Ph.D, Department ofReMedkic T-002, UCSD Medkal Center, 225 Dickin-gm Strect, San

v

eo, CA 92103. A applicationsmust be receivd byl7June 1988.AnAffirmatnAction/Equa Oppotunity Explyfr.

POSTDOCrORAL RESEA mR : Requiredimmediately to work on the cloning, s andregulation of dehydrogenases involved in steoid hor-mone and chemical carcinogen metabolism. Salary andposiiion tide comensurate wi . This is an

pimion, and is available for 1 to 3 years.Please send curricuhm vitae and names of three refer-ences to: Dr. Trevor AL Penni D t of

,Uv of Penn So f

POSTDOCTORAL TRAINING is avaiable in mo-kcular, cdlular, and nutritonal aspects of carcnogenesisin the Eppky Instite for Research in Cancer ancAlliedDiseases of the University of Nebraska Medical Ccnter.Research progrms include, for example: Chemistry offormation and metbolism of ni sa , nitrosa-mines, and hydrazines; mechanisms ofcarc e ofpolycyclichy and othcr nos, lymphmagenesis; cell diffentatiion; and growt fcos; biochemical genetics particularly as relaes t scpbityand resistance to cancer development; m u andDNA repair; molculr biology of cancer; virses andcll immortization and truaifoemation; oicology offood additives; and on and cancer. Ihe EppleyInstitut is well equip for both in vitro and in vowork P ora lican should have a Ph.D. inchy,mi y,m , phamacologyor reated disciplines. Stipends are competiive. Pleasesubmit currilm vitae, hree leers ofand summary of reseatch interests to: Dr. EdwardB ick, Dietor, Epey Iastute fir Resarch inCancer and Allied Disass, Univerity of NebraskaMedical Centr, Omaha, NE 68105. Refer to position#8-6073 in all co spondenc. An Equa Opo0u4y/AffirmatieAction Employer.

PROTEIN CHEBUISS AND CELL BIOLO-GISTS IN BLOOD RESEARCH. Research positions(postdtl fellow to senior research scientist) imme-di=ateyavailable for qualified M.D.'s /Ph.D.'s to partici-pate in multle NIH-funded search prects relited to

of complement and coagul s msinplatelet activation and bood doting. Pror mrini ormpertise in phyical biocenity, protn c miyand/or cell biogy desired. Position fr higl motivatedM.D. desiring basic or applied research trainng intransfision medicine abo available. Conta: Peter J.Sims, MiD., Ph.D., Medical ResearchFoundatin, 825 NE 13th Street, Oklahoma City,OK 73104. An Equa OppotnityL4ffirnai AtionExployer.

RESEARCH AND DEVELOPMENT SCIEN-TIST/PROJECr. Kallestad slocated onLake Hazetine in suburban Minnapolis, cuently hasopportunities in our Research and Develpment Depart-ment for individuals to assist in the deveblpment ofhuman enzyme immunoasays and non4isotopic, quanti-tative immuno ys with clinicalir nta-tionL Appicants must have a ini of an M.S., orequivalent, in biodistry or immunoloRy with 2+years of industrial experince developing ELISAs fromproduct concept through manufacturing or familiarityXerS offer competitive salaries adSs, andpeasant working conditions. If you havc the aboveqlifications and are in d in Ing a fast growingorainiation, please send detailed r6suni in Coo R Gay KallkestdDi y 1000 Lak Hazel-

tne Drive, Chaska, 1 55318. Equal Opprtniy

570

RESEARCH ASSOCIATE position open 1 Sep-tenber 1988 to work in classical and quantum gravitythory. Requirents: Ph.D., publicatons, strg ck-ground in generl relatvity, quantum algeometry, and field Io itial poinment is for 1year, renewabe for scond year, subject to availbility offimding. By 10 May 1988, c vitae and one ormore ltters of reconmndati should bc receved by:James W. York, Departent of Physics and Astroo-my, CB# 3255, University of North CarolEa, Cha-pel Hill,NC 27599-3255. UNC ir an Equal Opp0reui-tylAjjsaiveAction Exployer.RtESEARLCH ASSOCIATE for university in Central

Ohio. To conduct research in molecular ge , includ-ing desip andesxutio of re ant DNA i-ments; isolae, subdonc and detcrmine the DNA se-quence of genes in Neunispo; analyze the rcgulat ofgene expression by isolation of messe RNA for gelelectroresis and Norw blot ani; map tn-scriptiol Start and stop sites and intron sequence ofcloned genes. Rcquires a Ph.D. in biochemity ad2years ofresearch experince in biochemitrwbich in-cs1year do DNA-mediated an ion, molcular ing, DNA sequencing, and isolation andNorthern analysis ofRNA. Forty hours per week; 8 a.mto 5 p.m.; $22,440 per year. Qualified apdlicants rcplyimmediately with rsuvm to: A. MacLean, JO#3041428, Ohio Bureau of E -mloyment Services,P.O. Box 1618, Columu, OH U3216.

RESEARCH ASSOCIATEPENN SrATE

Responsibk for conducting research in p chem-ityand en y cursa Ph.D.i mirwitl a s l d in biophysical clemexpiince inERom l y n promten ui-

caton, isolation and c tization of carbohydrate-proteins is also required. Send rtsumi by9

May 1988 to:Dr. Joseph Viflafranca

EvaPuh Po&sorof ChemistryThe Pensyania Stae Unvrsiy

412 ChnlervLbrtUnisy Par, PA 16802

AnAfiaAction/Eal Opport y Ep r.Women and mn ies to

RESEARCH POSMONThe Universities Space Research Association (USRA)

has an ongoing need for research scis and asistantsto imnvti processes or Irod which are limited orafcted by conditons not by the Space and Earthenvironm ts (e.g., miogravity, high vacuum, etc.).Candidates should be abk to quan these limiionsand cffcts eorcally and/or pimentally. They willbe excted to: develp teories for various heat andmass tansport processes encountered during crystlgrowth and solidficaton, develop numerkal codes andperform analysis on mass redistribution, interface stabil-ity, defectformtion in strcural electronic, and opticalmaterias, and/or evaluate the effects of residual Vravia-tional forces on matrials and processes. Addionally,candidates could providc assistance with ground-basedand flight hardware related to studies to ascertain thepotential beefit ofprocessing materials in Spacc. Workwill be conducted in theMicrogravity Sciences Divisionof the Space S e Laborory, NASA/Mar SpaceFlight Center. Scientist must have Ph.D. in reated Eeld(e.g., materias science or physics). Assistants must havcundergraduate degree in related fielk The appointmntwill be for 1 year, renwable. Salary commensurate withexperiene (minimum: $33,000 per year for scients)with full medical and rtrement benefits. Scnd rsumito: USRA, Dr. James M. Van Asdne, 4950 Corpo-rate Drivc, Suite 100, Huntsvilk, AL 35806. USRA isan Equl Opp.runity/Afumai*eActom Emplyer.RESEARCH POSMONS AVAILABLE: NiH-

fiuded positions at postdoctoral tormsearch assstprofessor level to be involved in testing the hypothesisthat [Ca2-] is the primary regulator of smooth musclecontractie fuction. Myoplasmic [Ca2+] is measuredwith aequotn and corelatd with 1,4,5-IP3, myosMphosphorylation, shortening velocity, and stress. Con-tct: Chis Remhold M.D. or RichardMurphy Ph.,Box 146, Umers ofV Chlelle VA22908. Equal OppetyIAJeirAaion Enmplyf.

POSITIONS OPEN

RESEARCH SCIENTIST. The Microsurgical Re-search Laboratries invites applications from a Ph.D.with postdoctoral experiencc for assistnt professor ofsurgery (tenure-track). The candidate should comple-ment and be committed to collaborativc work with twodinician/rsearchers and a Ph.D. physicist involved instudics of microcirculation, tissue iscmia and electricali4nuries. The researcher will be expected to develop anetrnally funded research program and cross appoint-ment in a basic science art of the MedicalFaculty ofMcGill University will be encouraged. Salary:$30,000 (under review). Send statement of researchinterests, curriculum vitae and three lettcrs ofrecommen-dation to: C. L, rian, MD McGill Univei,Division of Plastic Suger, Royal VioaH ta687 Pine Avenuc West, Monl QC H3A lAI.In accrdanc with Canadian ati u

oniderwtin in thefit tc, wi ien todtism and pewanent iden of C . Othees areenouned to appy and will be onvidered.

RESEARCH SCIENTISTExperienced Ph.D. in neuropharmacology, neurotoxi-

cology, or neuroteratology to study the effects of envi-ronmental exposure to trace elemnts, particularly therole of aluminum on the developing brain and cognitivefunction. Incumbent will be expected to provide quarte-ly reviews of the literature on aluminum. An ability tocommunicate with both peer and lay groups essentiaLSalary range: $40,000 to $50,000 commensurate withexpErience. Send curriculum vitae and three letters ofrefrence to: Personnel (fob Ref. #531), NYS Insti-tufe for Baic Research inD Dabilitis,1060 Forest Hill Road, Staten Isd, NY 10313.M/FIHAfunnatiweActo/qual Opporunity Employer.

RESEDARLCH SPECIALIST to perform basic re-search in plant molecular genctics with DNA plantviruses. Speific duties includk preparation ofprotoplastsfrom plant and cultured cells, transfction of protplastswith caulimovirus and recombinant DNA, and detectonofreplication in diates and gene products as a resultof foction with forcein DNA. ust be proficient inplan protoplast preparation, transfection of protoplastsusing ectoporation technology, molecular doning/restructunngofDNA, and analysis ofgene expression byhybridization bltting, immunosorbent tests, and enzy-matic assays. Ph.D. in plant pathology, genetics, orbiochemistry and at least 2 years ofrelcvant postdoctoralexperience are required. Forty hours per week; $21,000per year. Send resume to: T. Moore, KY704457,De nt for Empl ent Services, 300 SouthUpper Stret, Lx ton, KY 40508.

SENIOR RESEARCH ASSOCIATE-Positionavailable for protein chemist or molecular biologist towork in the fidd ofcapillary electrophoresis on problemsof biolopal significance. Work will incude analysis andpurificatlion of picomole quantities of material. Theprogam involves collaboration with Harvard Medical

hoiol and the Biotechnology industry. One to 2 yearsof postdoctral experience desirable. Send r6sumi andthree references to:Dr. B.L Kr, Barnett Institute,Nordtetern Univcrsity, 360 luntington Avenue,Boston, MA 02115. Norheatm isanEqal Opportuni-ty/AffimaieAcaion, Titk IX Uniey.

SKIN BIOLOGISTEstee Lauder, Inc., a world leader in quality cosmetics

and skin care, is seeking ahl motivated individual tojoin our Biological Rcsearch U'nit.The successful candidate will havc a Ph.D. in either

biocheistry, physiology, or immunology. Some post-doctoral expence prefered as well as expericnce work-

with mammal skin.This positin offers an excelent working environment,

salry, and company-paid bencfits.Please send curiculum vitae and names of threc refer-

ences to:Profesional Recruitment

Estee Lauder, Inc.125 PindLawn RoadMelle, NY 11747

SCIENCE, VOL. 240

POSITIONS OPEN

I

POSITIONS OPEN

BioHybrid Technologies is a Massachu-setts based corporation developing arti-ficial internal organs which incorporateliving cells. Current emphasis is on diabetesresearch with pancreatic islets and betacells.

ResearchScientistA Senior Scientist position is available for ahighly motivated individual with a back-ground in cell biology. Requires PhD orMDwith a minimum of two years post-doctoralresearch experience involving mammaliancell culture. Familiarity with islet/endocrineresearch desirable.

Biol-lybrid Technologies, Inc.Attn: Personnel910 Tumpike RoadShrewsbury, MA 01545

Abbott FermentationResearch RunsA Steady CourseAdvanced research projects that are well conceived,well funded and well managed are par for the courseat Abbott Laboratories. We're a $4.4 billion healthcareleader with an outstanding reputation for soundmanagement and technical innovation. Thosestrengths show through in our Chemical andAgricultural Products Division and the careeropportunity we offer.

Molecular Biologist/Agricultural Microbiology R&DWe seek a PhD in Molecular Biology with a minimum of2 years postdoctoral experience to conduct basicresearch in microbial insecticides and develop newproducts based on recombinant strains. Goodcommunication skiHls are essential and industrialexperience in microbial insecticides is preferred.Abbott Laboratories is headquartered in an attractivesuburban area north of Chicago. We provide anexcellent salary and benefits program featuring profitsharing and employee stock purchase plans. For moreinformation, send a resume in strictest confidence to:Keith Allen/Corporate Placement, Dept. 4/22,Abbott Laboratories, Abbott Park, IL 60064. Abbottis an affirmative action employer.

ABBOTr LABORATORIESBOualityHealth Care

1888-1988

-I

RESEARCHSCIENTIST!ASSOCIATE

Biotechnology Instrument SystemsPHARMACIA LKB Biotechnology is seeking a creativeperson with extensive knowledge and experience inbiochemistry/molecular biology to help develop toolsfor biomolecular separation and analysis. Emphasis of theposition will be the investigation of new instru-ment/reagent concepts for new products.Highest consideration will be given to self-motivated in-dividuals with broad interests and skills and the interestto work in the laboratory to develop novel methods and createprototype systems. Good communications skills are im-portant. An M.S. or Ph.D degree and relevant postgraduateexperience are preferred. Please send resume to:

Human Resources DepartmentPHARMACIA LKBBiotechnology Inc

800 Centennial AvenuePiscataway, New Jersey 08855

_) equal opportunity employer M / F /H /V

PharmaciaPharmacia LKB Biotechnology

BIOTECHNOLOGYIDIAGNOSTICSRESEARCH &DEVELOPMENTAt the Baxter Healthcare Corporation, Pandex Division,

our breakthroughs in innovative immunoassay technologyhave put us at the forefront of this field while helpingdrive our substantial rate of growth. Creative and in-dependent Scientists at the Ph.D, MS and BS level arenow needed to support our expanding biotechnologyefforts in the following areas:

* BIOPROCESSING* MOLECULAR BIOLOGY* RETROVIROLOGY/VIROLOGY* IMMUNOLOGY/IMMUNOCHEMISTRY* ASSAY DEVELOPMENT* MICROBIOLOGYAt Pandex you'll find a unique scientific environment

supported by the Fortune 75 Baxter, yet within an atmo-sphere where you'll play a key and independent projectrole while being recognized for your contribution. Ourorganization is located in an attractive suburban area 30miles north of Chicago and we offer excellent compensa-tion. For confidential consideration, please send resumeto: Anne McNicholl, Personnel Director, Baxter HealthcareCorporation, Pandex Division, 909 Orchard Street,Mundelein, IL 60060. Equal Opportunity Employer.

Pandex Division

Baxteri

Merrell Dow Research Institute, a world-wide leader in pharmaceutical and biologicalresearch, has two immediate openings for Senior Research Biochemists in the Depart-ment of Biochemical Sciences. Successful candidates will join a multidisciplinarygroupof biochemists and medicinal chemists to pursue new approaches to the preventionof atherosclerotic and degenerative diseases.

LIPID ENZYMOLOGISTWe seek a Ph.D. biochemist with 3-5 years of documented experience in the assay andpurification of lipolytic enzymes, interfacial catalysis in monolayer, emulsion, and mem-brane substrates, and a broad understanding of the role of lipids in disease states. Thischallenging career opportunity requires an enthusiastic, highly-motivated individualinterested in molecular mechanisms that underly disease states.

FREE-RADICAL BIOCHEMISTWe seek a Ph.D. biochemist with 3-5 years of documented experience in measurementof lipid peroxidation in biological membranes and cells, the chemistry of free radicalsin solution, in lipid bilayers, and in cell membranes and a working knowledge ofmechanisms of oxygen radical damage and the role of metals in lipid peroxidation. Theposition requires an individual who is strongly self-motivated and able to closely interactwith other chemists, biochemists, and pharmacologists.Merrell Dow Research Institute is located in suburban Cincinnati and offers excellentcompensation, comprehensive benefits, and relocation assistance.For confidential consideration, please send your curriculum vitae with names of threereferences to:

Personnel Services Manager(Refer to Job Code RU)

Merrell DowMERRELL DOW RESEARCH INSTITUTE

2110 East Galbraith Road, Cincinnati, OH 45215U.S. Citizenship or Permanent Visa Required

Equal Opportunity Empoyer M/F/HNV

BIOMEDICALMASS

SPECTROSCOPISTThe Department of Pharmacology,of Vanderbilt University invites ap-plications for a Research Associateposition from individuals wishing todevelop a career in biomedicalmass spectrometry. The estab-lished, multi-disciplinary MassSpectrometry Center has threemagnetic sector and four quadru-pole instruments and purchase ofaTSQ instrument is comtemplated.The successful applicant will havea recent Ph.D. in Chemistry or theBiomedical/PharmaceuticalSciences with experience in massspectrometry and the ability to inter-act effectively with a wide variety ofbiomedical scientists, while de-veloping independent lines of re-search and funding. Suitability-qualified candidates will be eligiblefor a tenure-back position. In-terested applicants should sendcurriculum vitae and names ofthree references by June 15, 1988to: Dr. Ian Blair, Director, MassSpectrometry Center, Pharmacol-ogy Department, School of Medi-cine, Vanderbilt University, Nash-ville, TN 37232. AA/EOE.

In Redwood City, California, you'll find a talented group ofresearchers who are focusing on some of the most challengingbiotechnological issues in the world today. At Genelabs we havea single aim: to develop new therapeutic and diagnostic productsfor selected human health care problems. The issues we face can'tbe solved with traditional approaches.To make major breakthroughs takes a better plan. The Genelabs'methodology: a strategic combination of proprietry technologies,international collaborations and a hand-picked, research-drivenscientific and management staff.

MOLECULAR BIOLOGISTPhD with 2-3 years experience in cDNA cloning and expressionin eukaryotic cells. Will be performing transfections into lymphoidcells, expression and then assay using antibodies against the pro-tein. Initial work will be in a joint project between Genelabs anda nearby university.

MOLECULAR GENETICISTPhD with a minimum 3 years postdoctral experience in mammalianmolecular genetics. Demonstrated expertise in the construction,characterization and screening of genomic libraries Will isolate andmap new genetic markers within the human genome using novelproprietary techniques.Our work environment is exceptional in our expanding facilitieslocated in the Seaport Centre on the San Francisco Peninsula.Please forward CV and names of 3 references in confidence to:GENELABS INCORPORATED, 505 Penobscot Dr, Redwood City,CA 94063. Attn: Human Resources. EOE.

GENELAB SI N C 0 R P 0 R A T E D

PhlarmacologistSyntex, an international leader in the pharma-ceutical and health care industry has an imme-diate opening in our Palo Alto research head-quarters for a PharmacologistIn this key position, you will assume leadershipresponsibilities as a staff researcher in the develop-ment of new drugs for the treatment of gastroin-testinal disorders. You must have a PhD in phar-macology, biochemistry or physiology and 2-6years' experience in gastrointestinal research. Astrong basic research background and publica-tions list are required. Industrial experience inpreferred.

Other positions currently available forBS/MS Biologists/Biochemists/Chemists. I

Syntex offers a competitivesalary, relocation and benefits

- package in a campus-like set-ting. For immediate considera-tion, please send your resumeto: Syntex, Professional Staff-ing, Dept. PS/S, 3401 Hillview

sYNTj-i-E Ave., Palo Alto, CA 94304. Anequal opportunity employer.

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" II

POSITIONS OPEN

SENIOR RESEARCH SCIENTIST. Ph.D. in vi-rology/microbiology roquired. Seeking an experiencedhighl qualified virologist willing to work with humanimmunodeficiency virus in a laboratory semng. Strongmolecular biology background essential with capabilityto develop and carry out AIDS research projects. Pleasesend curriculun vitac and names of three refcrences to:Dr. A. E. Friedman-Kien, Department ofMicrobiolo-gy, New York Uniity Medical Center, 550 FirstAvenue, New York, NY 10016. Equal OpportunityEmployrMIF.

SYSTEMS NEUROSCIENTIST: To establish anindependent research program in motor control support-ed by extramural funding, preferably in the vestibularmodultion of motor patterns in animals. The applicantmay participate in an interdisciplinary program indudingexperimental and theoretcal approaches to basic andclinical research in posture, the vestibular system, andmotor control, within a broader neuroscience institute.Ph.D. or equivalent is required; salary and staff rankcommensurate with experience and qualifications. Sendcomplete curriculum vitae, a brief statement of researchinterests, selected reprints, and three letters of recom-mendation to: Search Committee, Nurological Sci-anms Institute, Good Samaian Hospital an M alCenter, 1120 NW2th Avenue, Pr , OR97209-1595. Equal Opp pxi1yAjinnaeweActio Empko)e.TOXICOLOGIST PHARMACOLOGIST to be

supervisor and assistant director of university basedclinical analytic laboratory in mid-Atlantic region. Posi-tion carries faculty appointment at instructor or assistantprofessor level depending upon qualifications. Expertisein GC, GCUMS, HPLC necessary. The insiuion anAffirmatieAcn/Equal Opportunty Emtplyer. Please ad-dress inquiries to: Box 61, SCIENCE.

VERTEBRATE PHYSIOLOGISTIndiana State University, Department of Life Sciences

invites applications for a tenure-track appointment invcrtebrate physiology at the level of assistant/associateprofessor. Persons qualified in the area of cardiovascularor respiratory physiology are encouraged to apply. Asuccessful candidate wil be expected to obtain extramu-ral funding, to develop and maimain a vigorous, inde-pendent research program, and to teach m an area ofspecialization. Minimum requirements: Ph.D., postdoc-tora and teaching experience. Salary and rank comnuen-surate with qualifications. Send curriculum vitae, a briefdescription of current and future research interests, andhave fopr letters of reference sent from individualsfamiliar with your work to: Dr. ranodhy Mulkey,

Search Commitee, Depart-mentobfLife Sciences,Indiana State University, TerreHaute, IN 47809. Review of applications will begin 15May 1988 and continue until the position is filled. AnEqual Opportunity/AffinativeAaion Employer.

JPIJNASA VISITINGSENIOR SCIENTIST

ASTROPHYSICS DIVISIONSCIENCE OPERATIONS

The Jet Propulsion Laboratory invites applications tothe Visiting Senior Scicntist Program in the AstrophysicsDivision at NASA Headquarters to coordinate and assistin the management of science mission operations inNASARs Astrophysics Program. Duties include cogni-zance over all aspects of astrophysics science operationsduring the study and developmcnt phases of a mission,and management ofscience operations for these missionsduring the observing phase. This activity indudes assess-ment of program ob ives, plans and performance.Tenured fac ty investigators with expenence in theoperation of astronomy experiments or missions are thepreferred choice. Normal assignment in the VisitingSenior Scientist Program does not exce&d 2 years. Thedesired start date is early summer of 1988. Appointeesmust be U.S. citns or penanent resident, and areqpected to rtumrn to h m intitution folwing theirNASA asinment. Plcase provide curriculum vitae, bibli-ography, and the names offour references to:

Dr. Harry Askenas, 180-900Departnent U50

Jet Propulsion Laboratory4800 Oak Grove DrvePasadena, CA 91109

Telehone: 818-354-8251An Equa Opportunity Employer MIF

A major national tradc association is seeking a TOXI-COLOGIST to monitor animal and clinical safety tests,providc administrative and technical support to industryscicnce comnittees, and develop and manage a safetyinformation program. Applicant should have a Ph.D.degree or a Masters degree with Certification, andexpenence in developing protocols and conducting toxic-ity/safty testing. The applicant should also have demon-strated eccellent communication skills. Familiarity withcomputers and data basem ent is aplus Aplicant should forward a isum4,incuding a list of refer-ences, publications and presentations, and salary historyto: Dr. G. N. McEwen, Jr., Vice President-Science,The Cosnetic, Toiletry and Frarance Assocation(CITA), 1110 Vermont Avenue, N.W., Washington,D.C. 20005. CTFA is an Equal Opportunity Emplyer.

COURSESSUMMER COURSES IN

GROSS ANATOMY, HISTOLOGY,EMBRYOLOGY AND NEUROANATOMYWill be offered to medical, dental, health science, and

medical illustaton students by the Department ofAnat-omy and Cell Biology, Georgetown niversity,arting20 Junc 1988. For furt information, contact:

Dr. Martin Dym, ChairmanDepartment of Anatomy and Cell Biology

Georgtown Universityetown Universi Medical Center3900 Rse Road,NWWashington, D.C. 20007

Telephone: 202-687-1051

PROGRAM

UNDERGRADUATE FIELD TRAINNG PRI-MATE SOCIAL ECOLOGY: Outanding under-$raduate applications are being accepted fur partiapationi NSF-funded proam involving 30 days of fieldresearch on the socal ecology of stumptail macaques inMcico this summer and fulloow-up independent studyduring the subsequent academic year with Dr. Rasmus-sen of Wisconsin Regional Primatc Center. Awardsinclude frie tuition, room/board, and $1500 stipend.Academic credit.available.A icaon not andwomen u gradswes encouraged. NS Progam, TheSchool for Field Studies, 376 Halc Street, Beverly,MA 01915. Telephone: 617-927-7777.

SYMPOSIUM

SYMCPOSIUM ON OXYGEN BINDING HEMEPROTEINS: Strure, Dynamics, Function and Genet-ics will be held 9 to 13 October 1988 at AsilomarConference Grounds, near Monterey, California. Discus-sion willcenter on the dynamics and thermodynamics ofligand binding in monomeric and allosteric proteins,with an emphasis on the useofsite-dictd mutantsandpotcntial clinical applications. For information, contact:ProiLSar Janels Department ofChemist,UI r of New Meico, Albuquerque, NM87131.

FELLOWSHIPS

POSTDOCTORAL FELLOWSHIP is availableJuly 1988 to study th efcts of mutations in the insulinreceptor on insulin action. Recent Ph.D. graduates withbackound in recombinant DNA or cell biology areencouraged to apply. To qualify for this NIH ninggrant position, the applicant must be a U.S. citixen orpermanent resident. Applicants should send their curric-ulm vitae and three letters of refercnce to: James N.Living n, Box 693, Unversity of£Rochester Schoolof Medicine and Dentistry, 601 E3mwood Avenue,Rohse, NY 14642.t

POSTDOCTORAL FELLOWSHIP in molecularenocinogy, NIH(NRS)-supported, availabk 1 July1988 to study control of pitwtary hormone secretion.Applicant must be U.S. citizen with Ph.D. in molecularbiology or related field. Send curriculum vitae and namesOf three references to: Dr. Jerome Hershman, Endocri-nolo-W11D, West Los Angels VA-UCLA Medi-cal meer, Lo>s Angeks, CA 0-073.

574

POSTDOCrORAL FELLOWSHIPMARINE SCIENCE

Skidaway Institute of Oceanography, a unit of theUnivcrsity System of Georgia, invites applications fromnew or recent doctorates in science with interests inphysical oceanography, marinc chemistry, marine geology, or biologcal oceanography for a postdoctoral posi-tion. The 2-year fellowship is available 1 July 1988, andwill bc awarded on a competitive basis, wth primaryemphasis placed on research potential. The recipient maypursue research interests independently or in associationwith resident facult. Send curriculum vitae, a statemcntof research interests, and names of three references to:Rihard J. Buchner, Assita Director, SiddawayInstitute of Oce hy, P.O. Box 13687, Sav;n-nah, GA 31416. An E OpportunityAffirmative Ac-tion Eployer.POSTDOCTORAL FELLOWSHIP IN NEURO-

ANATOMY-NEUROPATHOLOGY at HarvardMcdical School. Research on aging, Alzheimer's disease,and limbic system. Send curriculurp vitae to: M. Mesu-lam, M.D, Neuroloy Departmncat, Bcth Isrel Hos-pital, 330 Brookline Avenuc, Bostin, MA 02215.

GEORGE S. WISEPOSTDOCTORAL FELLOWSHIPS

The Gcorge S. Wise Faculty of Life Sciences at TelAviv University offcrs each year postdoctoral fellowshipscommencing on 1 October in basic and applied biology.The Faculty is engaged in such rescarch areas as

anatomy, taxconomy and physiology of plants; anatomy,sociobiology and physiology ofanimals; marine biology;cellular and molecular biology and genet cs; lipid andprotein research; bioenergetcs; neurobiology; immunol-ogy; virology; cancer biology; biotechnology and naturepreservation.

Application forms can be obtained from: The Dean,The George S. Wise Faculty ofLife Sciences, Tel AvivUnivmrsity, Tel Aviv 69978, Isral. Deadline for appli-cations is 30 May of each year.

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